Abstract:A pioneer in the study of hypertension, Edward D. Freis, M.D., is best known for leading the 5-year Veterans Administration Cooperative Study on Antihypertensive Agents which proved the value of antihypertensive drugs in decreasing morbidity and mortality; this study was the first multi-clinic, double-blind, randomized, placebo-controlled trial of its kind. Freis's collection of articles, photographs, scrapbooks, and subject files chronicle his sixty-year career in the study of hypertension and hemodynamics.