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Umberto Saffiotti papers 1960-2007
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Biography

Biographical/Historical Note

From 1960 to 1968, Dr. Saffiotti conducted Carcinogenesis research in the Division of Oncology at the Chicago Medical School, where he became Professor of Oncology. Since 1968 he has been on the staff of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland. As Associate Scientific Director for Carcinogenesis from 1968 to 1976, he directed the expanding research program on chemical and physical carcinogenesis and contributed to establishing criteria for the evaluation of carcinogens. As Chief of the Laboratory of Experimental Pathology since 1974, he has directed an intramural research program which has developed and investigated animal and cellular models chiefly for respiratory and multifactorial carcinogenesis, mechanisms of inhibition by vitamin A, and the role of growth factors in the culture and transformation of epithelial cells. In the last decade, he has studied mechanisms of lung carcinogenesis by crystalline silica as a model for fibrosis-associated peripheral lung adenocarcinoma, and molecular mechanisms controlling the biological activity of mineral dusts.