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2009 H1N1 Flu Pandemic Response Archives Oral History Collection 2009-2010
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Contents List

Box | Folder Title
 
Series 1: Personal and Biographical, 1948-2016 [series]:
1 1
Rifles for Washington [first prize award for DAR essay contest: 'Atomic Energy - for War or Peace'], 21 June 1948
1 2-3
The Periscope of 1952 - Perth Amboy High School yearbook, 1952
1 4
United Synagogue Youth Second National Convention program booklet, 1952
1 5
Perth Amboy High School Class of 1952 - 35th reunion booklet, 1987
1 6
The Nineteen Fifty-Six Scarlet Letter - Rutgers yearbook, 1956
Map Drawer 24 3
Rutgers University Bachelor of Arts degree - diploma, 6 June 1956
1 7
Scope 1960 - University of Pennsylvania School of Medicine yearbook, 1960
Map Drawer 24 2
University of Pennsylvania - diploma, 15 June 1960
1 8
University of Pennsylvania Commencement Program, 15 June 1960
1 9
"Only You" written by James J. Kriegsmann and Norman Stanton (Stanley N. Cohen) - sheet music, advertising flyer, 1960
1 10
Achshav 25th anniversary yearbook, United Synagogue Youth, 1975
1 11
"DNA cloning: a personal perspective", by Stanley Cohen, 1988
1 12
The Search For Life: Genetic Technology in The Twentieth Century - Smithsonian exhibit pamphlet, 16 December 1987
2 22
The Search for Life: Genetic Technology in the Twentieth Century - invitation - [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 10 November 1987
2 14
Letter from Stanford President Donald Kennedy [in Newspaper and magazine clippings, press releases, brochures 1978-2004], 30 December 1982
 
Certificates [subseries]:
Map Drawer 24 3
Reserve Corps of the Public Health Service - assistant surgeon appointment, 20 June 1961
Map Drawer 24 1
Mount Sinai Hospital - July 1, 1960 to June 30, 1961 internship certification, 30 June 1961
Map Drawer 24 1
Reserve Corps of the Public Health Service - senior assistant surgeon certification, 1 July 1962
Map Drawer 24 1
License to Practice Medicine and Surgery in the Commonwealth of Pennsylvania, 9 January 1964
1 13
National Institute of Arthritis and Metabolic Diseases - certificate of completion of clinical associate duties, 30 June 1964
Map Drawer 24 1
North Carolina Board of Medical Examiners - certificate of reciprocity, 24 July 1964
Map Drawer 24 1
Duke University Medical Center and Affiliated Hospitals - certificate of completion of senior assistant residency duties, 30 June 1965
Map Drawer 24 1
The Department of Professional and Vocational Standards Board of Medical Examiners - certification, 7 October 1968
Map Drawer 24 3
Certificate of Appreciation for Acting Chairmanship of SOM Department of Genetics, 1986
 
Cohen Birthday Symposia [subseries]:
1 14-15
60th birthday symposium and celebration [talk, photographs, notes, cards], 1995
96
60th birthday - photograph album, 1995
1 16
70th birthday, 2005
1 17
Biotechnology in the 21st Century: a Scientific Symposium Honoring Stanley N. Cohen - photograph album, 2005
1 18
Cohen 75th birthday symposia - "35 years of DNA Cloning", 2010
1 19
Cohen 75th birthday symposia - guest book of congratulations, 2010
 
Business Activities [subseries]:
1 20
Cetus and other financial documents, 1976-1981
1 21
Medication Services, Inc. - business plan, 1987
1 27
New Brunswick Scientific Co., Inc.'s Universal Membrane Filtration Apparatus - brochure [in Newspaper and magazine clippings, press releases, brochures 1970-1978], undated
 
Society of the Medical Friends of Wine [subseries]:
1 22
Wine tasting at the 1987 Miami Winter Symposium - program, 10 February 1987
1 23
50th Anniversary - group photograph, January 1989
1 24
Tasting of recently released California wines - brochure, 14 November 1990
1 25
One Hundred Seventy-Fourth quarterly dinner - brochure, 12 June 1991
 
Clippings and articles about Dr. Cohen [subseries]:
1 26
Wellcome News, Spring 1970
1 27-29
Newspaper and magazine clippings, press releases, brochures, 1970-1978
1 29
Cathy - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 20 January 1978
1 29
Carol Katz - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 20 January 1978
2 1-3
Newspaper and magazine clippings, press releases, brochures, 1970-1994
2 4
Newsweek, 17 June 1974
2 5
Readers Digest, December 1975
2 6-7
Magazines and memorabilia, 1975-1979
2 8
Atlantic Monthly, February 1977
2 9
Time, 18 April 1977
2 10
Parents Magazine, November 1977
2 11
Stanford Magazine, Fall/Winter 1977
2 12-14
Newspaper clippings, letters, news releases, 1978-2004
2 15
Newsweek, 17 March 1980
2 16
Time, 30 June 1980
2 17-20
Magazines and memorabilia, 1980-1990
2 21
Scientific American, September 1981
2 22-23
Newspaper clippings, magazine articles, 1983-2001
3 1
Stanford Medicine, Fall 1984
3 2
National Geographic, December 1984
3 3
"Le mystique du génie génétique" - by Gilbert Charles, L'Express Aujourd'Hui, 1988
3 4
The Life Revolution, a UK Channel 4 television documentary - episode summaries, 1988-1989
3 5
"First cloner" - by Lisa Bain, Penn Medicine, Winter 1990-1991
3 6-8
Magazines and memorabilia, 1991-2000
3 9
Center Focus, Summer 1993
3 10-11
Newspaper clippings, brochures, memorabilia [photographs], 1993-1999
3 12
Center Focus, Fall 1994
3 13
The Pennsylvania Gazette, June 1995
3 14-16
Newspaper clippings, brochures, memorabilia [including The Stanley N. Cohen, M.D., Endowed Scholarship update, April 2007], 2001-2013
3 17-18
Magazines and memorabilia, 2001-2015
 
Miscellaneous [subseries]:
3 19
In The Genetics Lab at Stanford I, II, and III - artwork signed by Chris Ranes, 1981
3 20
Card from Cloris and Herman, 22 August 1981
3 21
Letter from congresswoman Anna G. Eshoo to Dr. Cohen re: Stanford Dean's Medal, 26 September 2011
96
Framed illustration of design etched in granite on bench panel 09_15 "Recombinant DNA", 2012
Map Drawer 24 3
Framed cover of Proc. Natl. Acad. Sci., 3 August 2004
 
Photographs [subseries]:
3 22
Stanley N. Cohen lab bench exhibit - photograph of bench on display at the Smithsonian, 2011 January 5
3 23
Stanley Cohen - postdoctoral fellow, 1965
3 24
Stan photos - Stanford publicity photos, c.1980s
3 25
Lab party at Stan's house, c.1990s
3 26
[Dr. Cohen socializing], 1995
3 27
To Stan from Phil - trip to Taiwan photos, 17 July 1997
 
Winding Your Way Through DNA symposium, 25-26 September 1992 [subseries]:
4 1
Program booklet
4 2
"Stories from the scientists" teacher's guide
 
Audiovisual [subseries]:
4
"New ways of searching for tumor suppressor genes", Stanley N. Cohen; "Molecular markers. . . ", Simon Silver. Wayne State University, Frontiers in Molecular Medicine: Tape 2 - [vhs videocassette], undated
4
"Fishing for Genes", Sidney Brenner; "Molecular Markers of Pancreatic Carcinoma and their Clinical Correlations", Vainutis Vaitkevicius. Wayne State University, Frontiers in Molecular Medicine: Tape 3 [vhs videocassette], undated
4
Interviews with Watson & Cohen. Danmarks Radio - [2 vhs videocassettes], undated
4
"Biotechnology" NHK TV special, Japanese TV [featuring intro by Cohen] - [vhs videocassette], [1998]
4
The Life Revolution [documentary series] [6 vhs videocassettes], 1989
4
Bernard Cohen Memorial Lecture, Dr. Steven McNight - [vhs videocassette], 19 March 1991
4
Our Fragile Fortress - Dr. Stanley Cohen's interview [with thank you note] - [vhs videocassette], 22 April 1994
4
Innovative Lives [interactive], Lemelson Center, National Museum of American History, Smithsonian Institution - [cdrom, QuickTime format], 1996
4
The Remarkable 20th Century, volume eight: 1970s - [vhs videocassette], 2000
4
Eureka! The 20th Century's Top 15 Inventors. A&E Biography - [vhs videocassette], 2002
4
Shaw Prize special: Professsor Stanley N. Cohen [biography of Cohen and Boyer discovery] (English and Chinese versions) - [vhs videocassette], 2004
4
Sphygmomanometer (blood pressure meter) used by Stanley N. Cohen in medical school at the University of Pennsylvania, 1958-1960
4
Electronic records copied from hard drives [3 usb thumb drives]
Born digital
Biotechnology Heritage Award [mp4], 2016
Born digital
Archive-It web archive, top results for "Stanely N. Cohen" Google search conducted by HMD staff; Stanford Lab website ; Gabriel project; 80th birthday symposium, 2017 [view online]
 
Series 2: Correspondence, 1968-2016 [series]:
3 28-29
Requests: write manuscripts/articles, 1977-1995
3 30
Binder #1 - 0002A, 0007, 0105A, 0122A, 0004A, 0011, 0106A, 0006, 0012A, 0107A - [10 8" computer discs], 1979-1985
3 31
Binder #2 - 0023A, 0125A, 0129A, 0132A, 0140A, 0143A, 0205A, 0206A, 0213A, 0217A - [10 8" computer discs], 1980-1984
5 1
Binder #3 - 0218A, 0225A, 0228A, 0232A, 0220A, 0226A, 0229A, 0221A, 0227A, 0231A - [10 8"computer discs], 1982-1985
5 2
Binder #4 - 0002C, 0005C, A2125, 0009C, 0018C, 0003C, 0006C, 0012C, 0004C, 0007C, 0014C - [10 8"computer discs], 1983-1985
5 3
Binder #5 - 0234A, 0237A, 0245A, 0235A, 0238A, 0246A, 0236A, 0239A - [8 8" 8computer discs], 1984
5 4
Binder #6 - 0011C, 0023C, 0030C, 0015C, 0024C, 0033C, 0022C, 0025C, 0034C - [9 8" computer discs], 1985
5 5
Binder #7 - 0016C, 0207A, 0031C, 0137A, 0224A, 0001B, 0141A, 0243A - [8 8"computer discs], 1986
 
Chron files [subseries]:
5 6
4 January-24 May 1977
5 7
24 May-29 September 1977
5 8
4 October-20 December 1977
5 9
8 June-29 September 1978
5 10
1 October-15 November 1978
5 11
16 November-31 December 1978
5 12
1 January-31 March 1979
5 13
1 April-12 June 1979
5 14
12 June-23 August 1979
5 15
4 September-31 December 1979
5 16
2 January-7 April 1980
5 17
7 April-19 June 1980
5 18
19 June-24 September 1980
5 19
24 September-31 December 1980
6 1
6 January-19 February 1981
6 2
19 February-31 March 1981
6 3
31 March-9 July 1981
6 4
14 July-10 September 1981
6 5
11 September-29 December 1981
6 6
4 January-29 April 1982
6 7
4 May-3 June 1982
6 8
8 June-13 August 1982
6 9
13 August-31 October 1982
6 10
25 October-12 November 1982
6 11
4 January-11 April 1983
6 12
12 April-31 May 1983
6 13
2 June-28 July 1983
6 14
1 August-2 December 1983
6 15
2-30 December 1983
6 16
January-April 1984
6 17
May-August 1984
6 18
September-December 1984
6 19
January-April 1985
7 1
May -August 1985
7 2
September-December 1985
7 3
January-April 1986
7 4
May-August 1986
7 5
September-December 1986
7 6
January-June 1987
7 7
July-December 1987
7 8
January 1988
7 9
February 1988
7 10
March 1988
7 11
April 1988
7 12
May 1988
7 13
June 1988
7 14
July 1988
7 15
August 1988
7 16
September 1988
7 17
October 1988
7 18
November 1988
7 19
December 1988
7 20
January 1989
7 21
February 1989
7 22
March 1989
7 23
April 1989
7 24
May 1989
7 25
June 1989
7 26
August-December 1989
7 27
January-March 1990
8 1
April-May 1990
8 2
June-July 1990
8 3
July-September 1990
8 4
October-November 1990
8 5-6
January-June 1991
8 7-8
July-December 1991
8 9-10
January-June 1992
8 11-13
July-December 1992
8 14-16
January-June 1993
8 17-19
July-December 1993
9 1-2
1995
9 3
4 January-4 April 1996
 
Corporate Entities [subseries]:
9 4
American Broadcasting Company, 1981
9 5
Beckman Instruments, 1981-1982
 
Burroughs Wellcome [subseries]:
9 6-9
General, 1970-1988
9 10
Interferon shipments, 1979-1981
9 11-12
Interferon I, 1979-1980
9 13
Scholar Award, 1968-1987
9 14
Center for Science in the Public Interest, 1981
 
Cetus [subseries]:
2 13
"Cetus, a genetics engineering firm, plans initial public offer of 5.2 million shares" Wall Street Journal - clipping [in Newspaper clippings, letters, news releases 1978-2004], 14 January 1981
9 15-16
Biotechnology Award, 1987-1989
9 17
Flukes - Cetus' tenth anniversary issue, April 1982
9 18
Ronald E. Cape, 1984-1985
9 19
City of Medicine awards, 1996
9 20
Committee of Concerned Scientists, Inc., 1984
9 21
Czeck affair, 1971-1972
9 22
European Scientific Action Group for Nuclear Safety, 1986
9 23
Food and Drug Administration (FDA), 1973-1986
9 24
Human Gene Mapping Library, 1989-1990
9 25
Industrial Biotechnology Assoc., 1987
9 26
Life Sciences Foundation - LSF magazine, 2014-2015
9 27
Medispan archive, 1991-1995
9 28
Meridian Instruments, Inc., 1989
9 29
Modern Maturity, 1995
9 30
Monsanto, 1987
9 31
MSI, 1985-1987
9 32
National Research Council Commission on Life Sciences, 1995
9 33-34
National Science Foundation, 1985-1990
9 35
Nova, 1976-1977
9 36
Nuclear disarmament, 1984
9 37
Office of Technology Assessment Project (mapping of human genome), 1986-1987
9 38
Paid prescriptions, 1971
9 39
Robert J. and Claire Pasarow Foundation Medical Research Awards, 1989
9 40
People to People Citizen Ambassador programs, 1986
9 41
Pfizer, 1977-1982
9 42
Promis, 1977
9 43
Society for Developmental Biology, 1989
9 44
Synthetic oligonucleotides, 1992-1993
9 45
Technology transfer, 1989
 
Individuals [subseries]:
9 46
A - General, 1977-1991
9 47
Adams, Camellia W., 1987-1993
10 1
Adams, Camellia W. (cont'd), 1987-1993
10 2
Anderson, E. S., 1969-1976
10 3
Andre, Charles P., 1986-1992
10 4
Apirion, David, 1991
10 5
Axline, Stanton G., 1974-1980
10 6
B - General, 1980-1995
10 7
Bajorek, Teresa, 1992-1994
10 8
Barchas, Jack, 1982-1985
10 9
Bastia, Deepak, 1990-1991
10 10
Baumler, Ernst, 1981
10 11
Beachy, Philip A., 1980
10 12
Beale, Dr. John (Burroughs Wellcome), 1979-1980
10 13-16
Beatty, J. Thomas, 1979-1996
10 17-19
Beaucage, Serge, 1985-1991
10 20-25
Belasco, Joel, 1980-1992
10 26
Berg, Douglas E., 1981
10 27-30
Bibb, Mervyn, 1977-1994
10 31-35
Biek, Donald P., 1982-1992
10 36
Birnstiel, Max L., 1981-1983
10 37
Bjornsson, Thorir, 1972-1978
11 1-2
Blair, Deeda, 1986-1990
11 3-9
Blaschke, Terry, 1973-1991
11 10
Blau, Helen, 1986-1996
11 11
Bloomfield, Janine, 1984
11 12-13
Blum, Robert, 1976-1986
11 14
Bollen, Mathieu, 1995
11 15
Boothroyd, John, 1982
11 16
Botstein, David, 1979-1996
11 17
Boyer, Herbert, 1973-1995
11 18-19
Brace, Art, 1981-1993
11 20-23
Brasch, Michael [3.5 computer disc], 1986-1996
11 24-26
Brenner, Daniel, 1985-1992
12 1
Brenner, Daniel (cont'd), 1985-1992
12 2
Brevet, Jean, 1972-1983
12 3
Briggs, Russ, 1972-1975
12 4
Brinton, Charles, 1970-1971
12 5
Brothers, Lynda, 1973-1986
12 6
Brown, Arnold, 1971-1981
12 7
Brown, Byron William, 1976-1990
12 8
Brutlag, Simone Manteuil, 1993-1995
12 9-11
Bujard, Hermann, 1977-1997
12 12
Bush, Diane E., 1976
12 13-14
C - General, 1980-1996
12 15-16
Cabello, Felipe C., 1996-1998 [1]
12 17-21
Calos, Michele, 1981-1987
12 22
Cann, Howard, 1978-1984
12 23
Carpenter, Karen J., 1985-1991
12 24
Carpousis, A. J., 1996
12 25
Carrell, Laura, 1990
12 26-29
Casabadan, Malcolm, 1975-1988
12 30
Case, James, 1980
12 31
Caspari, David, 1981-1989
12 32-33
Cavalli, Luca, 1978-1990
12 34-35
Chang, Poa-Chun, 1990-1995
13 1
Chang, Poa-Chun (cont'd), 1990-1995
13 2-3
Chang, Shing, 1975-1985
13 4
Chang, Wen, 1996
13 5
Chao, Chuck, 1990-1996
13 6
Chater, Keith, 1983-2000
13 7
Chavez-Pardo, Rodolfo [photograph], 1972-1980
13 8
Chen, Carton, 1990-1996
13 9
Chen, Jianzhu, 1985-1986
13 10
Cheng, Te-Fang Delfine, 1985-1988
13 11
Chou, Joany, 1975-1993
13 12
Choudary, Prahbakara V., 1983-1985
13 13
Chretien, Michel, 1979-1993
13 14
Chung, Bon-Chu, 1995-1996
13 15
Clancy, Suzanne, 1982-1990
13 16
Claverie-Martin, Felix, 1995-1996
13 17
Clayton, David A., 1970-1996
13 18
Clewell, Don, 1985
13 19
Cochet, Madeleine, 1978-1981
13 20
Cohen, Gerald, 1994-1996
13 21
Cohen, Philip, 1995-1996
13 22-23
Conley, Dierdre, 1987-1996
13 24
Cortese, Riccardo, 1982
13 25
Cox, David, 1992
13 26
Crater, Dinene, 1996-1997
13 27
Cuatrecasas, Pero, 1981-1982
13 28-29
D - General, 1979-1996
13 30
Davies, Julian, 1991-1998
13 31
Davis, Randy, 1973-1977
13 32
Delappe, Irving, 1973-1976
13 33
Demain, Arnold L., 1980
13 34
Donahue, Tom, undated
13 35
Doyle, Dierdre [3.5 computer disc], 1986-1999
13 36
Driscoll, Janie, 1991-1994
13 37
Dubridge, Robert, 1981-1983
13 38
E - General, 1982-1990
13 39
Erlich, Henry, 1977-1984
13 40
Ermakov, Grigory, 1996
13 41
Espinosa, Manuel, 1996
13 42-43
F - General, 1981-1995
13 44-46
Falkow, Stanley, 1977-1989
13 47
Federman, Daniel, 1973-1977
13 48
Feinberg, Laurie, 1970-1985
13 49
Feitelson, Jerald S., 1978-1979
13 50
Flaggs, Gail, 1990-1991
13 51
Flowers, April, 1987-1988
13 52
Fraley, Cres, 1995-1997
14 1
Francke, Uta, 1988-1995
14 2
Franklin, Rosalind, 1998-1999
14 3
Funnell, Barbara, 1994-1995
14 4-5
G - General, 1974-1996
14 6-12
Gabain (von), Alexander, 1977-1996
14 13-17
Gaggero, Christina, 1993-1996
14 18
Gallo, Robert, 1986-1988
14 19
Ganesan, Adayapalam T., 1978-1991
14 20
Gazdar, Adi, 1981
14 21
Gelfand, David, 1979
14 22
Gershon, Elliot, 1981-1983
14 23
Geryk, Donna, 1986-1989
14 24-31
Gilbert, David, 1982-1996
15 1-4
Gilbert, David (cont'd), 1982-1996
15 5
Glazner, Fred, 1981
15 6
Gold, Lynn, 1981-1982
15 7
Goldstein, Avram, 1980-1988
15 8-9
Gossard, Francis, 1980-1988
15 10-11
Grant, Sarah, 1981-1994
15 12
Grobstein, Clifford, 1977
15 13
Gullberg, Martin, 1996
15 14-16
Gustaffson, Petter, 1977-1992
15 17-18
H - General, 1980-1996
15 19
Haase, Steven, 1985
15 20
Hackett, Christopher, 1998-1999
15 21
Hagedorn, Curt, 1995-1996
15 22-23
Hagege, Juliette Martine, 1991-1996
15 24
Hakanson, Rolf, 1982-1983
15 25
Hamm, Thomas, 1986
15 26
Hanawalt, Philip C., undated
15 27
Hannigan, John F., Jr., 1973-1977
15 28
Hansten, Phil, 1971-1976
15 29
Hedges, Robert, 1975-1988
15 30-31
Helinski, Donald R., 1975-1995
15 32
Hendrich, Brian, 1991
15 33
Henning, Karla, 1986-1994
15 34
Herbert, Ed, 1980-1982
15 35-36
Hernandez, Rachel, 1988-1993
15 37-38
Herzenberg, Leonard, 1971-1986
15 39
Herzenberg, Leonard (Brenner/Nolan dispute), 1987-1990 [1]
15 40
Herzenberg, Leonore, 1980-1987
15 41
Ho, Coy Choke, 1980-1993
15 42
Hoffman, Barbara, 1996
15 43-45
Hoffman-Liebermann, Barbara, 1978-1990
16 1
Hogness, David, undated
16 2
Hollister, Leo, 1973-1976
16 3
Hood, Lee, 1987-1989
16 4-6
Hopwood, David, 1994-1996
16 7
Hsu, Charles, 1979-1984
16 8
Hsu, Leslie, 1971-1972
16 9
Huang, Hongjin, 1994-1997
16 10
Huang, Huei-Jen Su, 1989-1991
16 11
Hunn, Gilbert, 1970-1979
16 12
I - General, 1990-1996
16 13
Illa, Robert, 1972-1994
16 14
Ingmer, Hanne, 1989-1996
16 15
Inloes, Doug, 1982-1984
16 16
Israel, Alain, 1979-1992
16 17-18
J - General, 1982-1995
16 19
Jain, Chaitanya, 1995-1996
16 20-22
Jaurin, Bengtake, 1980-1988
16 23
Jaurin, Kerstin R. V., 1983-1984
16 24
Johnson, Jacki, 1981-1984
16 25
Johnson, Matti, 1982-1983
16 26
Joklik, William K., 1981-1985
16 27
Joseph, Loren, 1976-1978
16 28-29
K - General, 1980-1996
16 30-31
Kaberdin et al., 1994-1996
16 32
Kan, Yuet Wai, 1985-1986
16 33
Katz, Leonard, 1990-2001
16 34
Kaufman, Randal J., 1981
16 35-36
Kedes, Larry, 1974-1992
16 37-38
Kendall, Kevin, 1983-1996
16 39
Kieser, Tobias, 1991
16 40
Kim, Eung-Soo, 1993-1996
17 1-5
Klug, Gabriele, 1985-1997
17 6
Knopf, Ulrich C., 1975-1977
17 7
Kondo, Jing, 1984-1985
17 8-10
Kopecko, Dennis, 1971-2011
17 11-16
Korn, Laurence, 1980-1986
17 17-18
Kretschmer, Peter J., 1973-1989
17 19
Krysan, Patrick, 1990-1993
17 20
Kunst, Frederik (Frank), 1977-1981
17 21
Kurth, Janice, 1988
17 22
Kwan, Catherine, 1995-1996
17 23-24
L - General, 1976-1996
17 25
Laird, Alan, 1979-1989
17 26
Lander, Eric, 1996
17 27-28
Lederberg, Esther, 1973-1978
18 1-3
Lederbeg, Joshua, 1976-1993
18 4-7
Lee, Stephen, 1984-1991
18 8-11
Lemaux, Peggy G., 1976-1991
18 12
Levinthal, Elliott, 1978-1984
18 13
Levy, Ronald, 1986
18 14
Lezhava, Alexander, 1995-1996
18 15
Liaw, Yen-Chywan, 1996
18 16-18
Liebermann, Danny, 1982-1989
18 19-22
Liebermann, Dan and Barbara (Hoffman), 1992-1995
18 23-26
Li, Limin, 1989-2001
18 27
Lin, Bai Ling, 1997
18 28-29
Lin-Chao, Sue, 1986-1996
19 1-13
Lin-Chao, Sue (cont'd) [3.5 computer disc], 1986-1996
19 14
Linebaugh, Catherine, 1981-1982
19 15
Lizardo, Esteban, 1984
19 16
Lockwood, Steve, 1979-1980
19 17
Losick, Richard, 1984-1989
19 18
Lovett, Paul, 1978
19 19
Lucio, Simon, 1981-1982
19 20-21
M - General, 1978-1997
19 22
Machbitz, Jack, 1973-1976
19 23
Mackie, George, 1995
19 24
Malamy, Michael, 1974-1976
19 25
Mandoli, Dina, 1981
19 26
Mangini, Richard J., 1975-1984
19 27
Mansour, Tag, 1979-1981
19 28
Marie, Helene, 1995
19 29
Marmur, Mildred, 1991-1992
19 30
Marquez, Leticia, 1981-1983
19 31
Marrs, Barry, 1976-1982
19 32
Masters, Millicent, 1993-1994
19 33
Mathews, Kathryn, 1983
19 34-35
McClintock, Barbara, 1980-1985
19 36
McCoubrey, Annette, 1971-1979
19 37-42
McDevitt, Hugh O., 1980-1996
20 1-3
McDowall, Kenneth, 1989-1996
20 4
McKee, Constance, 1989-1993
20 5-7
Meacock, Peter A., 1975-1987
20 8-11
Melmon, Kenneth, 1977-2002
20 12
Merigan, Thomas E., 1980-1997
20 13-14
Michaels, Alan, 1980-1982
20 15
Misfeldt, Dayton, 1982-1983
20 16
Mitchell, Dorothy, 1985-1993
20 17
Mitchell, Rodney, 1985-1986
20 18
Miczak, Wei, Lin-Chao, 1995-1996
20 19
Mondy, Russell, 1983
20 20
Montano, Monty, 1989
20 21
Moore, Terrence, 1973-1985
20 22-23
Morrell, Joan, 1975-1984
20 24
Mortelmans, Kristien, 1984
20 25
Murphy, Shari, 1981-1982
20 26
Myers, Richard M., 1985-1996
20 27-28
N - General, 1981-1996
20 29
Nakanishi, Shigatada and Numa, Shosaku, 1978-1982
20 30
Narang, Sarah, 1975-1979
20 31
Narro, Martha, 1984-1989
20 32
Nebert, Daniel W., 1980-1990
20 33
Nicolet, Charles, 1984-1987
20 34
Nisen, Perry, 1975-1984
20 35
Nishimura, Tad, 1972-1973
20 36
Noguchi, Toshitada, 1993-1996
20 37
Nolan, Garry P., 1984-1988
20 38
Nordstrom, Kurt, 1980-1983
20 39
Novick, Richard, 1977-1995
20 40
Nunberg, Jack H., 1978
20 41
O - General, 1976-1992
20 42
Ogawa, Joy, 1983
20 43
Oishi, Michio, 1995
20 44
Oliver, Noelynn, 1981-1982
20 45
O'Malley, Karen, 1980
20 46-48
Omer, Charles, 1980-1999
21 1
O'Reilly, Robert, 1977
21 2
Ott, Russell, 1981-1990
21 3-4
P - General, 1981-1996
21 5-6
Pandza, Kenan, 1995-1996
21 7
Pennaccio, Len, 1994-1995
21 8-10
Pettis, Gregg, 1988-1996
21 11
Phillips, Steve, 1969-1970
21 12
Platt, Terry, 1983-1985
21 13
Podlone, Michael, 1969-1974
21 14-15
Ptaschne, Kay A., 1971-1975
21 16-17
R - General, 1979-1996
21 18
Rabourdin-Combe, Chantal, 1980-1984
21 19
Ramu, Avner [photograph], 1972-1976
21 20
Ranes, Monica, 1981-1987
21 21-22
Ravnan, Britt, 1983-1993
21 23
Regnier, Philippe, 1994-1995
21 24
Remington, Jack, 1980-1988
21 25
Resnekov, Orna, 1991
21 26
Ringold, Gordon, 1977-1982
21 27
Risch, Neil, 1993-1994
21 28
Robertson, Channing, 1980-1982
21 29
Robinson, Harriet, 1980-1996
21 30-31
Robinson, W. S., M.D., 1995-1996
21 32
Robledo, Basil, 1983
21 33
Rogler, Charles E., 1974-1979
21 34
Romero, Edward, 1982-1983
21 35
Ronquillo, Ricardo, 1983-1984
21 36
Rosenstock, Irwin M., 1974-1977
21 37
Rothenberg, S. Michael, 1992
21 38
Rutherford, Philip C., 1993
21 39
Ruvkin, Gary B., 1984-1985
21 40-41
S - General, 1982
22 1
Sachs, Leo, 1982
22 2
Salkinoja-Salonen, Mirja, 1980-1981
22 3
Sameshina, Harry, 1981-1982
22 4
Schell, Jeff, 1975-1990
22 5
Schimke, Robert T., 1978
22 6-9
Schottel, Janet L., 1976-1994
22 10
Sgaramella, Vittorio, 1976-1991
22 11
Shapiro, Lucille, 1988-1996
22 12
Sharp, Phillip, 1970-1971
22 13
Sharrer, Terry, 1996
22 14
Shaw, William V., 1981-1988
22 15
Sherratt, David J., 1988-1993
22 16-17
Shiffman, Dov, 1988-1995
22 18-20
Shortliffe, Edward H., 1971-1990
22 21
Siddiqui, Aleem, 1979-1981
22 22
Silver, Rich, 1968-1976
22 23
Smith, Laurie, 1972-1975
22 24
Smith, Mark R., 1995
22 25
Smith, William, 1981-1982
22 26-28
Sninsky, John J., 1975-1985
22 29-31
Spector, David Martens, 1977-1999
22 32
Sobottka, Elizabeth, 1982-1984
22 33-36
Stein, David, 1981-1993
22 37
Steinman, Larry, undated
22 38
Stollar, David, 1975-1982
22 39
Stuart, Dorsey, 1980-1981
22 40
Swanson, Robert, 1998-2001
22 41
Sweetser, David, 1991
22 42
Szalay, Aladar, 1986
22 43
Szybalski, Waclaw, 1980-1996
23 1-2
T - General, 1980-1995
23 3-4
Tai, Julie Tsu-Ning, 1988-1997
23 5
Tatro, David, 1974-1982
23 6-8
Taylor, Dean, 1975-1997
23 9
Taylor, Sandra, 1982
23 10-11
Timmis, Kenneth N., 1972-1984
23 12
Tomkins, Lucy S., 1983
23 13
Tooze, John, 1980
23 14-15
Troutt, Anthony B., 1984-1988
23 16
Ts'o, Dr.Paul O. P., 1993-1996
23 17-19
Tu, David, 1975-1988
23 20-21
Tucker, William T., 1979-1985
23 22
U - General, 1973-1991
23 23-25
Uhler, Michael D., 1980-1988
23 26
V - General, 1971-1986
23 27
Van Bree, Mark, 1982-1984
23 28
Van Den Berg, David, 1985-1995
23 29
Van Embden, J., 1971-1973
23 30
Van Zanten, Pamela, 1994
23 31-32
Vogtli, Martin, 1987-1994
23 33
Vollrath, Doug, 1993
23 34-35
W - General, 1980-1996
23 36
Wa, Xian, 1996
23 37
Wade, Nicholas, 1978-1984
23 38
Wagner, Gerhart, 1994
23 39
Walker, Daphne K., 1976-1978
24 1-5
Wallace, Douglas, 1979-1983
24 6
Wang, C. C., 1992-1993
24 7
Wang, Fubao, 1992-1996
24 8
Wang, Maureen, 1990-1995
24 9
Weissman, Sherman, 1981-1983
24 10
Westpheling, Janet, 1994
24 11
Wheeler, Catherine, 1981
24 12
Willetts, Neil, 1981
24 13
Wolfsen, Ada R., 1980-1981
24 14
Wraith, Sharon, 1975-1979
24 15
Wu, Ray, 1978-1999
24 16-20
Xu, Feng Feng, 1989-1996
24 21-22
Y - General, 1979-1994
24 23
Yang-Yen, Hsing-Fang, 1996
24 24-26
Yarden, Anat, 1988-1996
24 27
Yasuda, Jun, 1996
24 28
Yoder, John, 1981-1984
24 29
Yosten, Linda, 1973
24 30
Yu, Victor, 1974-1978
24 31-32
Z - General, 1980-1996
24 33
Zabielski, Jan, 1973-1975
24 34
Zilinskas, Raymond, 1982
24 35
Zweiger, Gary, 1987-1995
Born digital
Email archives [21.2 GB], 1999-2016

Cohen's emails from his sncohen@stanford.edu Stanford account that he sent to/forwarded to and administered by his Administrative Assistant, not those from Cohen's computers and managed by Cohen. These largely represent Cohen's administrative and lab activities, contrasted to the emails he personally managed on his same Stanford account.

 
Series 3: Recombinant DNA, 1977-1992 [series]:
1 28
Stanford University Medical Center News Bureau release of adaptation of Cohen Publication #77: Cohen, S.N. Recombinant DNA: Fact and fiction. Science 195:654-657 [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 14 February 1977
1 29
Edward M. Kennedy - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 13 November 1977
24 36-37
Cogene - Sagene, 1979-1992
24 38
Course on Molecular Genetics, Nairobi, 1985
 
Working group [subseries]:
24 39
Foreign guidelines, 1977-1983
25 1-4
Foreign guidelines, 1977-1983
25 5-6
Guidelines questionnaire, 1977-1979
25 7-10
Guidelines questionnaire - primary responses, 1977-1980
25 11
Risk assessment, 1977-1979
25 12-14
First report to COGENE from the working group on Recombinant DNA guidelines, 1979-1981
 
Series 4: Lab Administration, 1972-1999 [series]:
25 15-18
Commercial requests RHKO, 1996-2000
25 19
Graduate study syllabus, 1979-1986
1 28
SNC memo re Ulrich Knopf cloning chloroplast DNA of chlaymdomonas without permission [in Newspaper and magazine clippings, press releases, brochures 1970-1978], July 1976
25 20
Protocol for laboratory animals, 1981-1997
25 21
Safety, 1979-1992
 
Cohen Lab Procedure Manual [subseries]:
25 22-23
A manual of procedures used in the S. N. Cohen Laboratory, Department of Genetics, Stanford University, March 1988
25 24-26
A manual of procedures used in the S. N. Cohen Laboratory [Copy showing changes made], 1988
 
Equipment manuals and advertising [subseries]:
26 1
The Bionet Resource (Bionet satellite program), 1985-1989
26 2-3
Densitometer: quick scan R and C SN RID 180108 SP, 1977-1993
26 4-5
Electron microscopes, 1972-1981
 
Stanford-Taiwan Programs [subseries]:
26 6
Other Stanford Faculty, 1997
26 7
Proposal letter, 1997
26 8
Trip funding, 1997
26 9-13
Taiwan communications - SND/JD, 1992-1997
26 14
Taiwan Institute of Medical Biology (IMB), 1994-1998
26 15
Taiwan IMB/NSG proposal, 1993-1994
26 16
Taiwan IMB review/recommendations, 1994
26 17-18
Taiwan Institute at Stanford, 1991-1992
26 19-20
Stanford-National Taiwan University steering committee, 1992; 1995-1998
26 21
NTU-Stanford meeting - Taiwan, 2021 October 1997
26 22
Brown, Patrick, 1997
26 23
Chao, C.K., 1996-1998
26 24
Chen, Ding-Shinn, 1997-1998
26 25
Greenberg, Harry, 1997-1998
26 26
Kierkegaard, Karla, 1997
26 27
Lai, Ming-Yang, 1997
26 28
Lee, Lin-Shan, 1997
26 29
Lin-Chao, Sue, 1996-1998
26 30
Mocarski, Edward, 1997-1998
26 31
Sarnow, Peter, 1997
26 32
Shen, C.-K., 1997
26 33
Sung, Mei-Hwa, 1997
26 34
Wang, Patrick, 1997-1998
26 35
Wu, Cheng-Wen, 1999
26 36
Yeh, Shiou-Hwei, 1997
 
Series 5: Lab Notebooks and Workpapers, 1963-2010 [series]:
 
Bao, Kai [subseries]:
26 37
Notebook files [CD-R], 1999-2004
 
Lab notebooks [subseries]:
26 38
Genetics - 1, 17 June 1998-12 August 1999
27 1
Genetics - 2, 14 August 1999-6 February 2001
27 2
Genetics - 3, 11 December 2000-12 December 2001
27 3
Genetics - 4, 15 December 2001-1 May 2002
27 4
Genetics - 5, 8 April-31 December 2002
 
Bernstein, Jonathan [subseries]:
 
Notes [subseries]:
27 5-7
X-rays, 1989-1999
27 8
Notebook files [CD-R], 1996-2002
 
Lab notebooks [subseries]:
27 9
Untitled, 1996
27 10
Untitled, 1998-2003
27 11
WTof RWE; Smb is WT; Rapid LB time course; B103 backup [5 CD-R, 1 zip disc], 2000-2001
 
Biek, Donald P. - Notes [subseries]:
27 12
par slides, undated
27 13
Miscellaneous, undated
27 14
Streptomyces transposons, 1983-1984
27 15-16
par, 1983-1984
27 17
Streptoymces transposons - promoter selections, 1983-1985
27 18
Tn10 hops looking for pma mutants, 1984-1985
27 19
184 +- par stability, 1984-1986
27 20
Effect of rec mutations on pmaA plasmid instability, 1984-1986
27 21
pmaA complementation, 1984-1986
27 22
Isolation par- point mutants of psc101, 1984-1986
27 23
Untitled, 1984-1987
28 1-3
pmaB, C (him D, A), 1984-1988
28 4
Untitled, 1984-1988
28 5
pmaA poster - Gordon conference, 1985
28 6
pmaA multimer gels, 1985
28 7
Recombination tests in pmaA, 1985
28 8
Tn3 transposition in pmaA, 1985
28 9
Plasmid studies in rec[ ] -pmaA, 1985
28 10
Resolution of plasmid multimers in pmaA (+- Tn3 promoted), 1985
28 11
pmaA sectoring and tet dependent sectoring, 1985-1986
28 12
Untitled, 1985-1986
28 13
psc101 stability studies, 1985-1986
28 14
Constructing an SopABC derivative of psc101 par, 1985-1986
28 15
Untitled, 1985-1987
28 16
Chromosomal mutations affecting psc101 cmp, 1985-1988
28 17
pma-10 mini-tet studies, 1985-1988
28 18-19
recD paper, 1986
28 20
Notes, 1986-1987
28 21
Current, 1986-1988
28 22
RNase II assays, 1987
28 23
Untitled, 1987
28 24
rep fusion studies, 1987-1988
28 25
Involvement of IHF in the maintenance of plasmid psc101 in E. coli, 1988
28 26
Strains put in sc collection by D.B., 1988
28 27
Topoisomerase assays, 1988
28 28-29
Final versions of IHF papers, 1988-1989
28 30
pma-10 studies in progress, 1988-1989
28 31
TC promote exps, 1989-1990
28 32
or IHF +- par - transformation and stability studies, 1989-1991
28 33
REP (alternate gyrate site) studies, 1989-1991
28 34
Effect of GUR- on or IHF, 1989-1991
 
Brasch, Michael A. - Notes [subseries]:
28 35-36
SLP1 integration, 1987-1993
29 1-6
SLP1 replication, 1987-1993
29 7
SLP1 replication, 1993
29 8-11
PLJ101 replication, 1990-1991
29 12-13
SLP1 1nt and Xis, 1990-1992
29 14-16
PLJ101 replication, 1990-1993
29 17
PLJ101 replication, 1990-1993
30 1
PLJ101 replication (cont'd), 1990-1993
30 2-4
Untitled, 1992-1993
 
Chang, A.C.Y. (Annie) [subseries]:
 
Lab notebooks [subseries]:
30 5
1, 8 November 1976-7 April 1977
30 6
2, 7 April-16 August 1977
30 7
1, 17 November 1977-7 April 1978
30 8
4, 1 December 1977-16 April 1978
30 9
5, 16 April-28 July 1978
30 10
6, 28 July 1978-5 January 1979
30 11
7, 8 January-3 July 1979
30 12
8, 3 July-29 November 1979
30 13
9, 29 November 1979-29 March 1980
30 14
10, 1 April-15 September 1980
30 15
11, 15 September 1980-26 January 1981
30 16
12, 26 January-6 June 1981
31 1
13, 11 June-10 November 1981
31 2
14, 10 November 1981-3 March 1982
31 3
15, 4 March-19 June 1982
31 4
16, 19 June-20 September 1982
31 5
17, 21 October 1982-24 March 1983
31 6
18, 24 March-30 September 1983
31 7
19, 7 October 1983-9 April 1984
31 8
20, 10 April-16 November 1984
31 9
25, 13 July 1988-17 August 1989
31 10
Untitled, 21 August 1989-17August 1990
31 11
Untitled, 20 August 1990-21 October 1991
31 12
Untitled, 23 October 1991-5 October 1992
32 1
Untitled, 10 October 1992-3 May 1994
32 2
Untitled, 11 May 1994-6 September 1995
32 3
Untitled, 11 September 1995-21 January 1997
32 4
Untitled, 23 January 1997-3 June 1998
32 5
Untitled, June 1999-March 2000
32 6
Untitled, 29 March 2000-22 May 2001
32 7
Untitled, 23 May 2001-23 October 2002
32 8
Untitled, 24 October 2002-25 March 2004
32 9
Untitled, 25 March 2004
33 1
Untitled, 25 March 2004
 
Notes [subseries]:
33 2-4
[RNA synthesis, DNA synthesis], July 1969-April 1970
33 5-6
[DNA synthesis, B-galactosidase assay, lysozyme assay], May 1970-June 1971
33 7
[RNA synthesis], August 1970-July 1971
33 8-10
[Burst size, protein synthesis, nuclease activity], January 1971-January 1972
33 11-12
[Transformation experiments, isolation of DNA], March-September 1972
33 13-15
[Transformation experiments, extraction and isolation of DNA], September 1972-June 1973
33 16-17
[Transformation experiments, extraction and isolation of DNA], June-October 1973
33 18-20
[RI enzyme, staphy coli plasmid, mitochondrial DNA, xenopus DNA, miscellaneous], December 1973-November 1974
33 21
[HIN III, spreading, transformation], December 1974-November 1975
34 1-2
[HIN III, spreading, transformation](cont'd), December 1974-November 1975
34 3
[DNA extraction, transformation, agarose gel], November 1975-March 1976
34 4-5
Protocols and procedures, 1968-1981
34 6
Gels, orig. art, 1982
34 7-8
Product guides and procedure techniques, 1982-1997
34 9
PRSV, PSV2 - DNA, 1983-1990
34 10
Notebook files, 1992-1996
34 11
Notebook files [2 CD-R], 1997-2006
34 12-15
Protocols, 1994-1998
34 16-17
Results - ARD, NIPPI [2 3.5 computer discs], 1995-1998
34 18-20
Reagent and protocol manual, 1996-2003
34 21
Microarray, 1999
35 1-3
Gene search vector, 1999-2003
35 4-6
HLA-B associated transcript 3 (bat3), 2000-2003
35 7-8
Protocol II, 25 April 2003
 
Cheng, Tzu-Hao (Johnny) [subseries]:
35 9-11
X-rays, 2000-2003
 
Lab notebooks [subseries]:
35 12
Genetics - 1, 17 August 2000-15 July 2001
35 13
Genetics - 2, 6 July 2001-21 March 2003
 
Cohen, Stanley N. [subseries]:
 
Lab Notebooks [subseries]:
35 14
Misc. DH, 25 March-6 September 1963
35 15
Chloroquine, 20 December 1963-6 March 1964
35 16
Polymerase assays, 1963-1964
35 17
24 March-29 August 1964
35 18
DNA preparations of GSO4 Hg, 29 June-30 August 1965
35 19
Data II, 23 September-8 December 1965; 1986
36 1
Data 8, 8 May-10 August 1967
36 2-6
Taiwan Sabbatical, 1975-1994
36 7
The Stan Cohen lab family, 1995
 
Gilbert, David M. [subseries]:
 
Notes [subseries]:
36 8
Artwork, undated
36 9-10
X-ray films, undated
36 11
Miscellaneous notes [7.5 computer disc], 1977-1985
36 12
5S project II, 1980-1983
36 13
Blots - TU, 1983
36 14
5S project ex.C II, 1983
36 15
5S project I, ex. A, 1983
36 16
5S project, ex. D IV, 1984
36 17
Replication sorts, 1984-1985
36 18
X-ray films, 1984-1985
36 19
BPV artwork, 1985
36 20
X-ray films, 1985
36 21-22
Miscellaneous notes, 1985-1989
37 1
MuARS material, 1986-1987
37 2
HTC elutriations, 1987
37 3
Hamster elutriations, 1987-1988
37 4
Figures, 1988
37 5
Asilomar, 1988-1989
37 6
Lab meeting, February 1989
37 7
Lab meeting, 11 August 1989
 
Lab Notebooks [subseries]:
37 8
Cytogenetic studies of replication, 23 March-5 October 1984
37 9
Untitled, 17 January 1988-18 September 1989
 
Ingmer, Hanne [subseries]:
 
Lab Notebooks [subseries]:
37 10
Genetics - 1, 28 October 1989-13 April 1990
37 11
Genetics, 20 March-12 December 1990
37 12
Genetics, 13 December 1990-3 August 1991
37 13
Genetics, 6 August-12 December 1991
37 14
Genetics, 15 December 1991-26 May 1992
37 15
Genetics, 13 January-17 March 1992
37 16
Genetics - 5, 24 May 1992-6 February 1993
37 17
Genetics - 6, 11 February-20 July 1993
 
Notes [subseries]:
37 18
Post printing, undated
37 19
Scans, undated
38 1-4
REPA [2 3.5 computer discs], 1987-1993
38 5
General file, 1989
38 6
Oligos Hi, 1989-1993
38 7-8
Gels, etc. Hi, 1991
38 9-11
Clonings Hi, 1991-1993
38 12-13
Gels II Hi, 1991-1993
38 14
Notebook files, 1991-1998
38 15
Gels III Hi, 1993
38 16
XLA run, 2 November 1993
38 17
XLA run, November-December 1993
39 1-2
REPA, 1993
39 3
XLA run - REPA, 21-23 September 1993
39 4-5
Untitled, July-December 1993
39 6-7
SOS, 1994
39 8
Untitled, 1994-1995
 
Kendall, Kevin [subseries]:
39 9
Lab notebook file, 1985-1989
39 10
Lab notebook, 1985-1986
 
Lih, Chih-Jian (Jason) [subseries]:
 
Lab Notebooks [subseries]:
39 11
gas7, 1996-2002
39 12
DARPA tsg101, 1998-2000
 
Notes [subseries]:
39 13
Sequence gene information, 1996-2000
39 14
WI microassay, 2000
39 15
Microassay log - exp. record, 2000-2005
39 16
txr101, 2000-2003
39 17
txr18 BM041, April 2001
39 18
3, November 2001
39 19
Antibodies - anti-TXR1-1 - peptides - (f)AB-510-4NIK, RNGG, 2001-2006
40 1
Yeast 2 hybrid - PIAS I, 2002
40 2
txr101 work 4, 2003
40 3
Y2B, 2003-2004
40 4
txr101 5, September 2003
40 5
6, 2004
40 6
7, January 2005
40 7
Mouse work, 2006
40 8
8, January 2006
 
Lin-Chao, Sue [subseries]:
 
Lab Notebooks [subseries]:
40 9
1, 1987
40 10
2, 1988
40 11
3, 1988-1989
40 12
Works of Daniel/pcr beads, 10 April 1988-15 October 1989
40 13
TC-2 and TC-3, 1989-1990
 
McDowall, Kenneth [subseries]:
 
Notes [subseries]:
40 14-15
Rachel's notes, 1990-1993
40 16
Results, 1991-1994
41 1-2
Results (cont'd), 1991-1994
41 3
Notebook files, 1991-1995
41 4
Processed results, 1992-1993
41 5
RNase E cleavage of RNAi, 1992-1993
41 6-7
Analysis of RNE-1553 and RNE-1825 mutations, 1993-1994
41 8-9
General file, 1994-1995
 
Miller, Christine [subseries]:
 
Lab Notebooks [subseries]:
41 10
Untitled, 1997
41 11
Genetics, 1998
41 12
PAR, 1999
41 13
Genetics, 2000
42 1
Genetics, 2001
42 2
Genetics, 2002
42 3
Genetics, 2003
42 4
Genetics, 2004
42 5
Genetics, 2005
42 6
Genetics, 2006
43 1
Genetics, 2007
43 2
Genetics, 2008
43 3
Genetics, 2009
 
Notes [subseries]:
43 4-5
77, [1967?]
43 6
[Episomal DNA], March-October 1968
43 7-8
[Sucrose gradients], December 1968-July 1969
44 1
RTF, 1969
44 2-3
[Model E run, preparative run, sucrose gradients], November 1969-March 1970
44 4
[Model E run, sucrose gradients], April-December 1970
44 5
RTF, 1971
44 6-7
4, 1980
44 8-9
Par 1, 1980
44 10-12
Par 2, 1982
44 13-16
Untitled, 1982-1987
45 1-2
Par 3, undated
45 3-6
Par 4, 1983
45 7-9
Par 5, 1985
45 10-13
Par 6, 1986
45 14-15
Par 8, 1988
45 16-17
Par 9, 1989
46 1-4
Par 10, 1990
46 5-7
Par 11, 1991
46 8-11
Par 12, 1992
46 12-15
Par 13, 1993
46 16-17
Par 14, 1994
47 1-4
Par 15, 1995
47 5-8
Par 16, 1996
47 9-11
Par 18, undated
47 12
PCR quantification, 2010
 
Qin, Zhongjun [subseries]:
 
Lab Notebooks [subseries]:
47 13
Genetics - I, 8 August 1995-9 April 1996
48 1
Genetics - III, 27 February-20 August 1997
48 2
Genetics - V, 23 July 1998-16 August 1999
48 3
Genetics - VI, 20 August 1999-10 August 2000
48 4
Genetics - 7, 12 August 2000-15 March 2001
48 5
Genetics - 8, 19 March-18 October 2001
49 1
Genetics - 9, 19 October 2001-8 February 2003
49 2
Genetics - 10, 8 Feburary 2003-29 October 2004
 
Notes [subseries]:
49 3-4
Lab notebook file, 1995-2003
49 5
Untitled, 1996-2005
49 6-7
X-rays, 1995-2001
49 8-9
[Sequencing], 1996-2003
49 10-12
[X-rays], 1997-2003
49 13
[Sequencing], 2001-2003
49 14
[Reference articles], 2004
 
Shiffman, Dov [subseries]:
 
Lab Notebooks [subseries]:
50 1
MRNA stability, 13 September 1989-22 March 1990
50 2
Untitled, 30 November 1989-12 April 1991
50 3
Untitled, 25 October 1990-25 March 1992
50 4
Untitled, 8 March-18 June 1992
50 5
Untitled, 26 March 1992-23 April 1993
 
Zhang, Hong [subseries]:
 
Notes [subseries]:
50 6
Senescence - smurf2 - northern, 2000
50 7
Senescence - FACS, 2000
50 8
Senescence - microarray, 2000-2001
50 9
Notebook files [CD-RW], 2000-2007
50 10
Senescence - caveolin, 2001
50 11
Senescence - h tert, 2001-2004
50 12
Untitled, 2001-2006
50 13
Senescence - smurf2 - western, 2002
50 14
Senescence - smurf2 III, February-August 2003
 
Lab Notebooks [subseries]:
50 15
Untitled, 13 January-12 November 1999
50 16
Untitled, 12 March 1999-1 August 2000
50 17
Senescence - smurf 2I, November 2000-September 2001
50 18
Senescence - smurf 2II, September 2001-February 2002
51 1
Senescence - smurf2 - western, 2003
51 2
Senescence smurf2 IV, September 2003-May 2004
51 3
Senescence - smurf2 - western, 2004
51 4
Senescence - smurf2, June 2004-May 2005
51 5
Senescence - smurf2, June 2005-January 2006
51 6
Untitled lab notebook, undated
51 7
[unknown creator] lab notebook Nick translation of pSNAC 38 and pSNAC 5, 7 January-22 April 1981
51 8
[Jeff Dangl, MUT, etc.] lab notebook, 14 September 1983-9 March 1987
51 9-10
[unknown creator] lab notebooks, 1987-1988
51 11
[Gary Zweig/Dave Gilbert] T-Ag control of ori-linked gene expression and loose papers, 1988-1989
51 12
[Gene X] lab notebook, 13 September 1989-5 January 1990
51 13-14
Peptide [multiple contributors, Annie Chang, Dave Gilbert et al.], 1995-1999
51 15-16
Maps-Sequences [microarray sequence data graphs; multiple contributors, Annie Chang et al.], 1996-2002
 
Series 6: Publication Activity, 1959-2016 [series]:
 
By Number [subseries]:
52 1-3
Bound reprints - #1-200, 1961-1989
52 4-6
1 - Comparison of autologous, homologous, and heterologous normal skin grafts in the hamster cheek pouch, 1961
52 7
3 - Complex formation between chloroquine and ferrihaemic acid in vitro, and its effect on the antimalarial action of chloroquine, 1964
52 8
4 - Spectrophotometric studies of the interaction of chloroquine with deoxyribonucleic acid, 1965
52 9
5 - Inhibition of DNA and RNA polymerase reactions by chloroquine, 1965
52 10
7 - Specificity of initiation and synthesis of RNA from DNA templates, 1966
52 11
8 - Role of DNA in RNA synthesis - XI. Selective transcription of and DNA segments in vitro by RNA polymerase of Escherichia coli, 1967
52 12
12 - Genetic transcription in bacteriophage and: Studies of and mRNA synthesis in vivo, 1968
52 13
13 - Multiple molecular species of circular R-factor DNA isolated from Escherichia coli - Nature, 1969
52 14-15
15 - Non-chromosomal antibiotic resistance in bacteria - II. Molecular nature of R-factors isolated from proteus mirabilis and Escherichia coli, 1970
52 16
18 - Isolation of catenated forms of R factor DNA from minicells, 1970
52 17
19 - Further studies on the synthesis of RNA in vitro by enzyme-template complexes isolated from induced and lysogens, 1971
52 18
20 - Genetic expression in bacteriophage and. IV: Effects of P2 prophage on and inhibition of host synthesis and and gene expression - Virology, 1971
52 19
23 - Nonchromosomal antibiotic resistance in bacteria. V: Isolation and characterization of R factor mutants exhibiting temperature-sensitive repression of fertility - J. Bact., 1972
52 20
26 - Nonchromosomal antibiotic resistance in bacteria: Genetic transformation of Escherichia coli by R-factor DNA - Proc. Natl. Acad. Sci. USA, 1972
52 21
27 - Recircularization and autonomous replication of a sheared R-factor DNA segment in Escherichia coli transformants - Proc. Natl. Acad. Sci. USA, 1973
52 22
28 - Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II: Structure of drug resistance (R) factors and F factors - J. Mol. Biol., 1973
52 23
32 - Construction of biologically functional bacterial plasmids in vitro - Proc. Natl. Acad. Sci. USA, 1973
52 24
33 - Molecular and genetic studies of an R factor system consisting of independent transfer and drug resistance plasmids - J. Bact., 1973
52 25
35 - Effects of and development on template specificity of Escherichia coli RNA polymerase - Biochim. Biophys. Acta, 1974
52 26-27
36 - A computer-based system for the study and control of drug interactions in hospitalized patients - in Drug Interactions (P.L. Morselli, S. Garattini, S.N. Cohen, eds.), 1974
52 28
39 - Replication and expression of Styahylococcus plasmid genes in Escherichia coli - Proc. Natl. Acad. Sci., 1974
52 29
40 - Replication and transcription of eukaryotic DNA in Escherichia coli - Proc. Natl. Acad. Sci., 1974
52 30
41 - Aryl hydrocarbon hydroxylase induction in mouse peritoneal macrophages and blood-derived human macrophages - Proc. Soc. Exp. Biol. Med., 1974
52 31
42 - Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid - J. Bact., 1974
52 32
44 - A method for selective cloning of eukaryotic DNA fragments in Escherichia coli by repeated transformation, 1974
52 33
45 - Utilization of two distinct modes of replication by a hybrid plasmid constructed in vitro from separate replicons - Proc. Natl. Acad. Sci. USA, 1974
52 34
47 - Transformation of Escherichia coli by plasmid chimeras constructed in vitro: A review - in Microbiology-1975 (D. Schlessinger, ed.), 1974
52 35
48 - Transformation of Escherichia coli by recombinant plasmid replicons constructed in vitro - in Mechanisms in Recombination (R.F. Grell, ed.), 1974
52 36
50 - In vitro construction of bacterial plasmid replicons containing prokaryotic and eukaryotic genes, 1974
52 37
51 - Site-specific recA-independent recombination between bacterial plasmids: Involvement of palindromes at the recombinational loci - Proc. Natl. Acad. Sci. USA, 1975
52 38
52 - Occurrence of insertion sequence (IS) regions on plasmid deoxyribonucleic acid as direct and inverted nucleotide sequence duplications. - J. Bact., 1975
52 39
56 - The manipulation of genes - Sci. Am., 1975
52 40
57 - Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coli, 1975
52 41
58 - Cloning, isolation, and characterization of replication regions of complex plasmid genes, 1975
52 42
59 - Indirect selection of bacterial plasmids lacking identifiable phenotypic properties - J. Bact., 1975
52 43
60 - Studies of mouse mitochondrial DNA in Escherichia coli: Structure and function of the eucaryotic-procaryotic chimeric plasmids - Cell, 1975
52 44
61 - Replication control in a composite plasmid constructed by in vitro linkage of two distinct replicons, 1976
52 45
63 - Structural evolution of bacterial plasmids: Role of translocating genetic elements and DNA sequence insertions- Fed. Proc., 1976
52 46
64 - A computer-based approach to the promotion of rational clinical use of antimicrobials, 1976
52 47
65 - Uniform nomenclature for bacterial plasmids: A proposal - Bacteriological Reviews, 1976
52 48
66 - Gene manipulation - New Eng. J. Med., 1976
52 49
69 - Replication region fragments cloned from Flac+ are identical to EcoRI fragment f5 of F, 1976
52 50
70 - Involvement of multiple translocating DNA segments and recombinational hotspots in the structural evolution of bacterial plasmids, 1976
52 51
72 - Receptivity of physicians in a teaching hospital to a computerized drug interaction monitoring and reporting system - Medical Care, 1977
52 52
75 - Selected translocation of plasmid genes: Frequency and regional specificity of translocation of the Tn3 element. - J. Bact., 1977
52 53
77 - Recombinant DNA: fact and fiction - Science, 1977
52 54
78 - Recombinant DNA: fact and fiction - West. J. Med., 1977
52 55
82 - In vivo site-specific genetic recombination promoted by the Eco RI restriction endonuclease. - Proc. Nat. Acad. Sci. USA, 1977
53 1
83 - Revised interpretation of the origin of the pSC101 plasmid - J. Bact., 1977
53 2
84 - Cloning of Hind III and Eco RI fragments of the R6-5 plasmid by insertional inactivation - in Microbiology (D. Schlesinger, ed.), 1978
53 3
88 - Site-specific DNA deletions occurring adjacent to the termini of a transposable ampicillin resistance element (Tn3) - J. Mol. Biol., 1977
53 4
89 - Phenotypically cryptic EcoRI endonuclease activity specified by the ColE1 plasmid - Proc. Natl. Acad. Sci. USA, 1978
53 5
91 - Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid - J. Bact., 1978
53 6
93 - A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments - Cell, 1978
53 7-8
97 - Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase - Nature, 1978
53 9
99 - Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-[ ]-lipotropin precursor - Proc. Natl. Acad. Sci. USA, 1978
53 10
100 - Nucleotide sequence of cloned cDNA for bovine corticotropin-Β-lipotropin precursor - Nature, 1979
53 11
106 - Immunological detection and characterization of products translated from cloned DNA fragment - in Methods in Enzymology, vol. 68 (R. Wu, ed.), 1979
53 12
109 - Analysis of gene control signals by DNA fusion and cloning in Escherichia coli - J. Mol. Biol., 1980
53 13
112 - Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage. In vivo probe for transcriptional control sequences - Proc. Natl. Acad. Sci.USA, 1979
53 14
113 - Identification and characterization of a self-regulated repressor of translocation of the Tn3 element - Proc. Natl. Acad. Sci USA, 1980
53 15
115 - Transposition protein of Tn3: identification and characterization of an essential repressor-controlled gene product - Nature, 1979
53 16
116 - Translocation specificity of the Tn3 element: characterization of sites of multiple insertions - Cell, 1980
53 17-20
117 - Transposable genetic elements - Sci. Am., 1980
53 21
119 - Initiation of protein synthesis in bacteria at a translational start codon of mammalian cDNA: effects of the preceding nucleotide sequence - Proc. Natl. Acad. Sci USA, 1980
53 22
120 - A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces - Nature, 1980
53 23
121 - Effect of DNA sequences adjacent to the terminal of Tn3 on sequential translocation - Molec. Gen. Genet., 1980
53 24
122 - Structure and genomic organization of the mouse dihydrofolate reductase gene - Cell, 1980
53 25-27
123 - Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance - Cell, 1980
53 28
124 - 3'-end labeling of DNA with [a-32p] cordycepin 5'-triphosphate - Gene, 1980
53 29
125 - Studies of cloned DNA encoding the structure for the bovine corticotropin-Β-lipotropin precursor protein - Ann. N.Y. Acad. Sci., 1980
53 30-31
126 - F plasmid provides a function that promotes recA-independent site-specific fusions of pSC101 replicon - Nature, 1980
53 32
127 - In vitro gene fusions that join an enzymatically active Β-galactosidase segment of amino-terminal fragments of exogenous proteins: Escherichia coli plasmid vectors for the detection and cloning of translational initiation signals - J. Bact., 1980
53 33
128 - Structural organization of human genomic DNA encoding the pro-opionelanocortin peptide - Proc. Natl. Acad. Sci. USA, 1980
53 34
131 - Transposition and control - Cold Spring Harbor Symp. Quant. Biol., 1981
53 35
132B - Organization of human genomic DNA-encoding pro-opiomelanecortin - in Expression of Eukaryotic Viral and Cellular Genes (Patterson, Kazariainen, Soderlund, Oker-Blom, eds.), 1981
53 36
133 - Cloning and expression in Streptomyces lividans of antibiotic resistance genes derived from Escherichia coli - J. Bact., 1981
54 1
134 - Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA-termination signal - Proc. Natl. Acad. Sci. USA, 1981
54 2
139 - Specialized cloning vectors for hepatitis B virus gene expression in Excherichia coli - Hepatology, 1982
54 3
140 - Characterization of the structural gene and putative 5'-regulatory sequences for human proopoimelanocortin - Nature, 1982
54 4
144 - Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces lividans - Molec. Gen. Genet., 1982
54 5
146 - Decay of mRNA in Escherichia coli: Investigation of the fate of specific segments of transcripts - Proc. Natl. Acad. Sci. USA, 1983
54 6
149 - Hybridization of cloned Rhodopseudomonas capsulata photosynthesis genes with DNA from other photosynthetic bacteria - J. Bact., 1983
54 7
150 - Ethanol production by saccharomyces cerevisiae immobilized in hollow-fiber membrane bioreactor, 1983
54 8-10
151 - Nucleotide sequence of the partition locus of Escherichia coli plasmid PSC101 - Gene, 1983
54 11
154 - Hollow-fiber membrane bioreactors using immobilized E. coli for protein synthesis - Biotechnology and Bioengineering, 1983
54 12
155 - Streptomyces lividans RNA polymerase recognizes and uses Escherichia coli transcriptional signals - Gene, 1984
54 13
156 - Effects of alterations in the translation control region on bacterial gene expression: use of cat gene constructs transcribed from the lac promoter as a model system - Gene, 1984
54 14-16
157 - Structural and functional analysis of the par region of the pSC101 plasmid - Cell, 1984
54 17
158 - Plasmid formation in Streptomyces: excision and integration of the SLP1 replicon at a specific chromosomal site - Molec. Gen. Genet., 1984
54 18
159 - Growth-rate dependent regulation of mRNA stability in Escherichia coli - Nature, 1984
54 19-20
160 - Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic-rxcA transcript - Cell, 1985
54 21
161 - Partitioning of the PSC101 plasmic during cell division - in Plasmids in Bacteria (D. R. Helsinki, S. N. Cohen, D. B. Clewell, D. A. Jackson, A. Hollander, eds.), 1985
54 22
162 - DNA cloning: historical perspectives - in Biogenetics of Neurohomonal Peptides (Ferring Symposium 1983; R. Hakanson, J. Thorell, eds.), 1985
54 23
163 - Structural analysis of the gene encoding human proopiomelanocortin - in Biogenetics of Neurohormonal Peptides (Ferring Symposium 1983; R. Hakanson, J. Thorell, eds.), 1985
54 24-26
164 - TU elements: a heterogeneous family of modularly structured eucaryotic transposons - Mol. Cell. Biol., 1985
54 27-28
165 - SLP1: transmissible streptomyces chromosomal element capable of site-specific integration, excision, and autonomous replication - in Microbiology (Proceedings of the Third American Society for Microbiology Conference; C. L. Hershberger, ed.), 1985
54 29
166 - Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces - Molec. Gen. Genet., 1985
54 30-33
167 - Hormonally mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L. cells - Mol. Cell. Biol., 1985
54 34
168 - Streptoymces contain Escherichia coli-type A + T-rich promoters having novel structural features - Gene, 1985
55 1-2
168 - Streptoymces contain Escherichia coli-type A + T-rich promoters having novel structural features - Gene (cont'd), 1985
55 3
170 - Promoter elements of Streptomyces Lividans and their expression - in Biological, Biochemical and Biomedical Aspects of Actinomycetes (Proceedings of the Sixth International Symposium on Actinomycetes Biology), 1985
55 4-5
171 - Sequences from sea urchin TU transposons are conserved among multiple eukaryotic species, including humans - Mol. Cell. Biol., 1986
55 6-7
172 - Sequence of the cDNA encoding porcine pro-opiomelanocortin - Biochim. Biophys. Acta, 1986
55 8-9
173 - Structural analysis of plasmid and chromosomal loci involved in site-specific excision and integration of the SLP1 element of Streptomyces coelicolor - J. Bact., 1986
55 10-11
174 - The stability of E. coli gene transcripts is dependent on determinants localized to specific mRNA segments - Cell, 1986
55 12
318 - Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor - Mol. Microbiol., 1986
55 13-16
176 - Human homologous of TU transposon sequences: polypurine/polypyrimidine sequence elements that can alter DNA conformation in vitro and in vivo - Mol. Cell. Biol., 1986
56 1
177 - Recombinant DNA methodology - chapter 11 in Genetics (G. Zubay, ed.), 1986
56 2
179 - Chromosomal and extrachromosomal functions that affect plasmid stability in E. coli - in Banbury Report 24: Antibiotic Resistance Genes: Ecology, Transfer and Expression (S. B. Levy, R. P. Novick, eds.), 1986
56 3
180 - Bovine papilloma virus plasmids replicate randomly in mouse fibroblasts throughout S-phase of the cell cycle - Cell, 1987
56 4
181 - The effect of premature termination of translation on mRNA stability depends on the site of ribosomal release - Proc. Natl. Acad. Sci. USA, 1987
56 5
183 - Plasmid transfer in Streptomyces lividans: Identification of a kil-kor system associated with the transfer region of pIJ101- J. Bacteriol., 1987
56 6
184 - Biological consequences of segmental alterations in mRNA stability: Effects of deletion of the intercistronic hairpin loop region of the R. capsulatus puf operon - EMBO J., 1987
56 7
186 - Recombinant DNA methodology (Chapter 32) - in Biochemistry (G. Zubay, ed.), 1988
56 8-9
187 - Site-specific insertion of biologically functional adventitious genes into the Streptomyces lividans chromosome - J. Bacteriol., 1988
56 10
188 - Stable inheritance of bacterial plasmids: practical considerations in the release of organisms into the environment - in Environmental Biotechnology: Reducing Risks from Environmental Chemicals Through Biotechnology (G. Omenn, ed.), 1988
56 11
189 - Complete nucleotide sequence of the Streptomyces lividans plasmid pIJ101 and correlation of the sequence with genetic properties - J. Bacteriol., 1988
56 12
190 - Analysis of recombination occurring at the SLP1 att sites - J. Bacteriol., 1988
56 13
191 - Pleiotropic effects of localized Rhodobacter capsulatus puf operon deletions on production of light absorbing pigment-protein complexes- J. Bacteriol., 1988
56 14
193 - SLP1 genes and sites involved in integration of the element into the genome Streptomyces lividans - in Biology of Actinomycetes '88 (Y. Okami, T. Beppu, and H. Ogawara, eds.), 1988
56 15-16
194 - Structural and functional analysis of transcriptional control of the Rhodobacter capsulatus puf operon - J. Bacteriol., 1989
56 17
195 - SLP1: A paradigm for plasmids that site-specifically integrate in the actinomycetes - in Mobile DNA (D. Berg and M. Howe, eds.), 1989
56 18
196 - TU elements and puppy sequences - in Mobile DNA (D. Berg and M. Howe, eds.), 1989
56 19
197 - A cloned regulatory gene of Streptomyces lividans can suppress the pigment deficiency phenotype of different developmental mutant - J. Bacteriol., 1989
56 20
198 - Involvement of integration host factor (IHF) in maintenance of plasmid pSC101 in Escherichia coli: Characterization of pSC101 mutants that replicate in the absence of IHF - J. Bacteriol. [in folder with 199], 1989
56 20
199 - Involvement of integration host factor (IHF) in maintenance of plasmid pSC101 in Escherichia coli: mutations in the topA gene allow pSC101 replication in the absence of IHF - J. Bacteriol. [in folder with 198], 1989
56 21
200 - Identification and characterization of a locus inhibiting extrachromosomal maintenance of the Streptomyces plasmid SLP1 - Molec. Gen. Genet., 1989
56 22
201 - Analysis of mammalian cell genetic regulation in situ using retrovirus-derived "portable exons" carrying the E. coli lacZ gene - Proc. Natl. Acad. Sci USA, 1989
56 23
202 - Identification and analysis of transcriptional regulatory signals for the kil and kor loci of Streptomyces plasmid pIJ101 - J. Bacteriol., 1989
56 24
203 - Initiation of pro-opiomelanocortin mRNA from a normally quiescent promoter in a human small cell lung cancer cell line- Gene, 1989
56 25
204 - Rate-limiting endonucleolytic cleavage of the 2.7 kb puf mRNA of Rhodobacter capsulatus is influenced by oxygen - in Molecular Biology of Membrane-Bound Complexes in Phototrophic Bacteria (G. Drews and E.A. Dawes, eds.), 1990
56 26
205 - Role of DNA superhelicity in partitioning of the pSC101 plasmid - Cell, 1990
56 27
206 - Position effects on the timing of replication of chromosomally integrated simian virus 40 molecules in Chinese hamster cells - Mol. Cell. Biol., 1990
56 28-29
207 - Rapid two-stage PCR amplification of chromosomal DNA segments in lysates made from monolayer cultures attached to microcarrier beads - Gene, 1990
56 30-31
209 - Mutational and functional analysis of the korA and korB gene products of Streptomyces plasmid pIJ101- Molec. Gen. Genet., 1990
56 32
210 - Degradation of puf mRNA in Rhodobacter capsulatus and its role in the regulation of gene expression - in Post-Transcriptional Control of Gene Expression, Vol. H 49 (J.E.G. McCarthy and M.F. Tuite, eds.), 1990
57 1
211 - Isolation and characterization of Rhodobacter capsulatus mutants defective in oxygen regulation of the puf operon - J. Bacteriol., 1990
57 2-3
212 - Combined actions of multiple hairpin loop structures and sites of rate-limiting endonucleolytic cleavage determine differential degradation rates of individual segments within polycistronic puf operon mRNA- J. Bacteriol., 1990
57 4
213 - Replication timing of DNA sequences associated with human centromeres and telomeres - Mol. Cell. Biol., 1990
57 5-7
214 - Effects of translation on degradation of mRNA segments transcribed from the polycistronic puf operon of Rhodobacter capsulatus - J. Bacteriol., 1991
57 8-9
215 - The rate of processing and degradation of antisense RNAI regulates the replication of ColE1-type plasmids in vivo- Cell [3.5 computer disc], 1991
57 10
216 - Gyrase-dependent stabilization of pSC101 plasmid inheritance by transcriptionally active promoters - EMBO J., 1991
57 11-19
217 - Mouse genomic DNA sequences homologous to sea urchin TU elements are genetically stable polydispersed repeats useful for analysis of multiple RFLPs - Genomics, 1992
57 20
218 - Propagation of pSC101 plasmids defective in binding of integration host factor - J. Bacteriol. [3.5 computer disc], 1992
Born digital
218 - Electronic files, 1992
57 21
219 - Reconstruction of a Streptomyces linear replicon from separately cloned DNA fragments: Existence of a cryptic origin of circular replication within the linear plasmid - Proc. Natl. Acad. Sci. USA [3.5 computer disc], 1992
Born digital
219 - Electronic files, 1992
57 22
220 - The chromosomal integration site for the Streptomyces plasmid SLP1 is a functional tRNATyr gene essential for cell viability - Mol. Microbiol. [2 3.5 computer discs], 1992
Born digital
220 - Electronic files, 1992
57 23
221 - Random-choice replication of extrachromosomal bovine papilloma virus (BPV) molecules in heterogeneous, clonally derived BPV-infected cell lines - J. Virol. [3.5 computer disc], 1992
Born digital
221 - Electronic files, 1992
57 24
222 - Localization and nucleotide sequences of genes mediating site-specific recombination of the SLP1 element in Streptomyces lividans - J. Bacteriol., 1993
57 25
223 - Excisive recombination of the SLP1 element in Streptomyces lividans is mediated by Int and enhanced by Xis - J. Bacteriol. [3.5 computer disc], 1992
Born digital
223 - Electronic files, 1992
57 26
224 - Timing of replication of beta satellite repeats of human chromosomes - Nucleic Acids Res., 1993
57 27
225 - The Escherichia coli pcnB gene promotes adenylation of antisense RNAI of ColE1-type plasmids in vivo and degradation of RNAI decay intermediates - Proc. Natl. Acad. Sci. USA [3.5 computer disc], 1992
Born digital
225 - Electronic files, 1992
57 28
226 - The ams-1 and rne-3071 temperature-sensitive mutations in the ams gene are in close proximity to each other and cause substitutions within a domain that resembles a product of the Escherichia coli mre locus - J. Bacteriol., 1993
58 1
227 - The partition (par) locus of pSC101 is an enhancer of plasmid incompatibility - Mol. Microbiol. [2 3.5 computer discs], 1993
Born digital
227 - Electronic files, 1993
58 2
228 - Activation of transcriptional fusions in Streptomyces lividans resulting from insertion of a 14-bp oligonucleotide - Nucleic Acids Res., 1993
58 3
229 - The pSC101 par locus alters protein-DNA interactions in vivo at the plasmid replication origin- J. Bacteriol. [3.5 computer disc], 1993
Born digital
229 - Electronic files, 1993
58 4
230 - Role of the imp operon of the Streptomyces coelicolor genetic element SLP1: Two imp-encoded proteins interact to autoregulate imp expression and control plasmid maintenance - J. Bacteriol., 1993
Born digital
230 - Electronic files, 1993
58 5
231 - The active form of the KorB protein encoded by the Streptomyces plasmid pIJ101 is a processed product that binds differentially to the two promoters it regulates - J. Bacteriol. [3.5 computer disc], 1993
58 6
232 - Excess intracellular concentration of the pSC101 RepA protein interferes with both plasmid DNA replication and partitioning - J. Bacteriol. [3.5 computer disc], 1993
Born digital
232 - Electronic files, 1993
58 7
233 - Bacterial plasmids: their extraordinary contribution to molecular genetics - Gene, 1993
Born digital
233 - Electronic files, 1993
58 8
234 - A+U content rather than a particular nucleotide order determines the specificity of RNase E cleavage - J. Biol. Chem., 1994
Born digital
234 - Electronic files, 1994
58 9
235 - Effects of nucleotide sequence on the specificity of rnets-dependent and RNase E-mediated cleavages of RNAI encoded by the pBR322 plasmid - J. Biol. Chem. [3.5 computer disc], 1994
Born digital
235 - Electronic files, 1994
58 10
236 - Mutations that affect regulation of the korB gene of Streptomyces lividans plasmid pIJ101 alter plasmid transmission - Mol. Microbiol. [3.5 computer disc], 1994
Born digital
236 - Electronic files, 1994
58 11
237 - Bidirectional replication from an internal origin in a linear Streptomyces plasmid - Science, 1994
Born digital
237 - Electronic files, 1994
58 12
238 - Transfer of the pIJ101 plasmid in Streptomyces lividans requires a cis-acting function dispensable for chromosomal gene transfer - Mol. Microbiol., 1994
Born digital
238 - Electronic files, 1994
58 13
239 - ard-1: A human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages - Proc. Natl. Acad. Sci. USA [3.5 computer disc], 1994
Born digital
239 - Electronic files, 1994
58 14
240 - afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans - Mol. Microbiol., 1994
Born digital
240 - Electronic files, 1994
58 15
241 - Isolation and characterization of plasmid mutations that enable partitioning of pSC101 replicons lacking the partition (par) locus - J. Bacteriol., 1995
Born digital
241 - Electronic files, 1995
58 16
242 - Effects of the pSC101 partition (par) locus on in vivo DNA supercoiling near the plasmid replication origin - Nucleic Acids Res., 1995
Born digital
242 - Electronic files, 1995
58 17
243 - Site-specific RNase E cleavage of oligonucleotides and inhibition by stem-loops - Nature, 1995
Born digital
243 - Electronic files, 1995
58 18
244 - RNA degradation in Escherichia coli regulated by 3' adenylation and 5' phosphorylation - Nature, 1995
Born digital
244 - Electronic files, 1995
58 19
245 - Surprises at the 3' end of prokaryotic RNA - Cell, 1995
58 20-21
246 - Sequences essential for replication of plasmid pIJ101 in Streptomyces lividans - Plasmid, 1995
Born digital
246 - Electronic files, 1995
58 22
247 - Monomer-dimer equilibrium of the pSC101 RepA protein - J. Mol. Biol., 1995
Born digital
247 - Electronic files, 1995
58 23
248 - Boundaries of the pSC101 minimal replicon are conditional - J. Bacteriol., 1995
58 24-28
249 - Disparate replication properties of integrated and extrachromosomal forms of bovine papilloma virus (BPV) in ID13 cells - J. Mol. Biol., 1995
Born digital
249 - Electronic files, 1995
59 1-3
250 - Transformed mouse cell lines that consist predominantly of cells maintaining bovine papilloma virus at high copy number - Virology, 1995
Born digital
250 - Electronic files, 1995
59 4
251 - The N-terminal domain of the rne gene product has RNase E activity and is non-overlapping with the arginine-rich RNA-binding site - J. Mol. Biol., 1996
Born digital
251 - Electronic files, 1996
59 5
252 - Plasmid transfer and expression of the transfer (tra) gene product of plasmid pIJ101 are temporally regulated during the Streptomyces lividans life cycle - Mol. Microbiol., 1996
59 6
253 - The platelet-derived growth factor α-receptor is encoded by a growth-arrest-specific (gas) gene - Proc. Natl. Acad. Sci. USA, 1996
Born digital
253 - Electronic files, 1996
59 7
254 - A novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells - Cell [3.5 computer disc], 1996
Born digital
254 - Electronic files, 1996
59 8
255 - Streptomyces linear plasmids that contain a phage-like, centrally located, replication origin - Mol. Microbiol., 1996
Born digital
255 - Electronic files, 1996
59 9
256 - The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer - Cell, 1996
Born digital
256 - Electronic files, 1996
59 10
257 - RNase E: still a wonderfully mysterious enzyme - Mol. Microbiol. [3 computer discs], 1996
Born digital
257 - Electronic files
59 11
258 - ARD-1 cDNA from human cells encodes a site-specific single strand endoribonuclease that functionally resembles Escherichia coli RNase E - J. Biol. Chem., 1997
Born digital
258 - Electronic files, 1997
59 12
260 - A developmentally regulated Streptomyces endoribonuclease resembles ribonuclease E of Esherichia coli - Mol. Microbiol., 1997
Born digital
260 - Electronic files, 1997
59 13
262 - Poly (A)- and Poly(U)-specific 3' tail shortening by E. coli ribonuclease E - Nature, 1997
Born digital
262 - Electronic files, 1997
59 14
263 - Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency - Proc. Natl. Acad. Sci. USA, 1998
Born digital
263 - Electronic files, 1998
59 15
264 - Replication at the telomeres of the Streptomyces linear plasmid pSLA2 - Mol. Microbiol. [3.5 computer disc], 1998
59 16-17
265 - Destabilized inheritance of pSC101 and other E. coli plasmids by MpdA, a novel two component system regulator - Mol. Microbiol., 1998
Born digital
265 - Electronic files, 1998
59 18
266 - gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation - Proc. Natl. Acad. Sci. USA [2 3.5 computer discs, zip disc], 1998
59 19
267 - Nuclear organization of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors - J. Cell Sci., 1999
59 20
268 - Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein - Mol. Cell. Biol. [2 3.5 computer discs], 1999
Born digital
269 - Electronic files, 1999
59 21
270 - Regulation of transfer functions by the imp locus of the Streptomyces coelicolor plasmidogenic element SLP1 - J. Bacteriol. [zip disc], 1999
59 22
271 - Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene - Gene [2 3.5 computer discs], 1999
59 23-24
272 - Separate roles of E. coli replication proteins DnaA and DnaB in the synthesis and partitioning of pSC101 plasmid DNA - J. Bacteriol. [3.5 computer disc, zip disc], 1999
Born digital
272 - Electronic files, 1999
59 25-26
273 - TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence - Cancer Res. [3.5 computer disc, zip disc], 2000
Born digital
273 - Electronic files, 2000
60 1
274 - Unpaired terminal nucleotides and 5' monophosphorylation govern 3' polyadenylation by Escherichia coli poly (A) polymerase I - Proc. Natl. Acad. Sci. USA [3.5 computer disc, zip disc], 2000
60 2-3
275 - Long palindromes formed in Streptomyces by non-recombination intra-strand annealing - Genes & Dev. [2 3.5 computer discs, zip disc], 2000
Born digital
275 - Electronic files, 2000
60 4
276 - Plasmid Replication and Copy Number Control - in The Horizontal Gene Pool: Bacterial Plasmids and Gene Spread (Christopher M. Thomas, ed.) [3.5 computer disc], 2000
Born digital
276 - Electronic files, 2000
60 5
277 - Mutational Analysis of the tra Locus of the Broad-Host-Range Streptomyces Plasmid pIJ101 - J. Bacteriol. [2 3.5 computer discs], 2000
60 6
278 - Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis - J. Biol. Chem. [3.5 computer disc, zip disc], 2001
60 7-11
279 - Neoplastic transformation and tumorigenesis associated with Sam68 protein deficiency in cultured murine fibroblasts - J. Biol. Chem. [4 3.5 computer discs, zip disc], 2000
60 12
280 - RNA degradosomes exist in vivo in Escherichia coli as multicomponent complexes associated with the cytoplasmic membrane via the N-terminal region of ribonuclease E - Proc. Natl. Acad. Sci. USA [zip disc], 2001
60 13
281 - A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control - Proc. Natl. Acad. Sci. USA [2 zip discs], 2001
Born digital
281 - Electronic files, 2001
60 14
282 - p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101 - Proc. Natl. Acad. Sci. USA [zip disc], 2001
60 15-16
283 - Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription - J. Bacteriol. [3 zip discs], 2001
Born digital
283 - Electronic files, 2001
61 1
284 - Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces - Genes and Dev. [zip disc], 2001
Born digital
284 - Electronic files
61 2
285 - Effects of 3' terminus modifications on mRNA functional decay during in vitro protein synthesis - J. Biol. Chem. [zip disc], 2001
Born digital
285 - Electronic files, 2001
61 3-7
286 - Escherichia coli poly(A) binding proteins that interact with components of degradosomes or impede RNA decay mediated by polynucleotide phosphorylase and RNase E - J. Biol. Chem. [3.5 computer disc, zip disc], 2001
Born digital
286 - Electronic files, 2001
61 8-9
287 - The RepA protein of plasmid pSC101 controls Escherichia coli cell division through the SOS response - Mol. Microbiol. [zip disc], 2001
Born digital
287 - Electronic files, 2001
61 10
288 - Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays - Genes Dev. [3.5 computer disc, zip disc], 2001
Born digital
288 - Electronic files, 2001
61 11-12
289 - Unraveling the essential role in conjugation of the Tra protein of Streptomyces lividans plasmid pIJ101 - Antonie van Leeuwenhoek [zip disc], 2001
61 13-14
290 - Isolation and properties of Gas8, a growth-arrest-specific gene regulated during pubertal development and post-meiotic differentiation of male germ cells to produce a protein associated with the sperm motility apparatus - J. Biol. Chem. [zip disc], 2002
Born digital
290 - Electronic files, 2002
61 15
291 - RNase G complementation of rne null mutation identifies functional interrelationships with RNase E in E. coli - Mol. Microbiol. [zip disc], 2002
Born digital
291 - Electronic files, 2002
61 16
292 - Analysis of DNA microarrays using algorithms that employ rule-based expert knowledge - Proc. Natl. Acad. Sci. USA [zip disc], 2002
Born digital
292 - Electronic files, 2002
62 1
293 - Survival mechanisms for Streptomyces linear replicons after telomere damage - Mol. Microbiol., 2002
Born digital
293 - Electronic files, 2002
62 2
294 - Negative regulation of cell growth and differentiation by TSG101 through association with p21Cip1/WAF1 - Proc. Natl. Acad. Sci. USA, 2002
Born digital
294 - Electronic files, 2002
62 3-5
295 - Polyadenylation can regulate ColE1 type plasmid copy number independently of any effect on RNAI decay by decreasing the interaction of antisense RNAI with its RNAII target - Plasmid [3.5 computer disc, zip disc], 2002
Born digital
295 - Electronic files, 2002
62
296 - Global Analysis of mRNA Decay and Abundance in E. coli at Single Gene Resolution Using Two-Color Fluorescent DNA Microarrays - Proc. Natl. Acad. Sci. USA [zip disc], 2003
Born digital
296 - Electronic files, 2003
62 7
297 - The catalytic domain of RNase E shows inherent 3' to 5' directionality in cleavage site selection - Proc. Natl. Acad. Sci. USA, 2002
Born digital
297 - Electronic files, 2002
62 8
298 - A Streptomyces coelicolor functional orthologue of Escherichia coli RNase E shows shuffling of catalytic and PNPase-binding domains - Mol. Microbiol. [zip disc], 2003
Born digital
298 - Electronic files, 2003
62 9-11
299 - Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci - Proc. Natl. Acad. Sci. USA [zip disc], 2003
Born digital
299 - Electronic files, 2003
62 12-13
300 - Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere binding protein essential for linear DNA replication - Genes Dev. [zip disc], 2003
Born digital
300 - Electronic files, 2003
63 1-6
301 - TSG101 interaction with HRS required for endosomal trafficking and receptor down-regulation - Proc. Natl. Acad. Sci. USA [CD-R], 2003
Born digital
301 - Electronic files, 2003
63 7-9
302 - Tsg101 control of human immunodeficiency virus type 1 gag trafficking and release - J. Virol. [CD-RW], 2003
Born digital
302 - Electronic files, 2003
63 10
303 - The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor - Genes Dev. [CD-RW], 2003
Born digital
303 - Electronic files, 2003
63 11-12
304 - RraA: a protein Inhibitor of RNase E activity that globally modulates RNA abundance in E. coli - Cell, 2003
Born digital
304 - Electronic files, 2003
63 13
305 - DpiA binding to the replication origin of E. coli plasmids and chromosomes destabilizes plasmid inheritance and induces the bacterial SOS response - J. Bact. [CD-RW], 2003
Born digital
305 - Electronic files, 2003
63 14
306 - Identification and characterization of a pSLA2 plasmid locus required for linear DNA replication and circular plasmid stable inheritance in Streptomyces lividans - J. Bacteriol. [CD-RW], 2003
Born digital
306 - Electronic files, 2003
63 15-17
307 - The Streptomyces coelicolor polynucleotide phosphorylase homologue, and not the putative poly(A) polymerase, can polyadenylate RNA - J. Bacteriol. [2 CD-RWs], 2003
Born digital
307 - Electronic files, 2003
63 18
308 - Genome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome - Mol Microbiol., 2004
Born digital
308 - Electronic files, 2004
63 19
309 - Global analysis of E. coli RNA degradosome function using DNA microarrays - Proc. Natl. Acad. Sci. USA [zip disc], 2004
Born digital
309 - Electronic files
64 1
310 - Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions - Oncogene, 2004
Born digital
310 - Electronic files, 2004
64 2-3
311 - SOS Response Induction by Β-Lactams Defends Bacteria Against Antibiotic Lethality - Science, 2004
Born digital
311 - Electronic files, 2004
64 4-5
312 - Reverse transcriptase activity innate to DNA polymerase I and DNA topoisomerase I proteins of Streptomyces telomere complex - Proc. Natl. Acad. Sci. USA, 2004
Born digital
312 - Electronic files, 2004
64 6-8
313 - Smurf2 up-regulation activates telomere dependent senescence - Genes Dev., 2004
Born digital
313 - Electronic files, 2004
64 9
314 - EST-based genome-wide gene inactivation identifies ARAP3 as a host protein mediating cellular susceptibility to anthrax toxin - Proc. Natl. Acad. Sci. USA [CD-RW], 2004
Born digital
314 - Electronic files, 2004
64 10
315 - An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma - Oncogene, 2005
Born digital
315 - Electronic files, 2005
64 11
316 - Regional organization of gene expression in Streptomyces coelicolor - Gene, 2005
Born digital
316 - Electronic files, 2005
64 12
317 - Effects of threshold choice on biological conclusions reached during analysis of gene expression by DNA microarrays - Proc. Natl. Acad. Sci. USA, 2005
Born digital
317 - Electronic files, 2005
64 13
318 - Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor - Mol. Microbiol., 2005
Born digital
318 - Electronic files, 2005
64 14
319 - The LDL Receptor-Related Protein 6 (LRP6) Mediates Internalization and Lethality of Anthrax Toxin - Cell, 2006
Born digital
319 - Electronic files, 2006
64 15
320 - Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome - Mol. Microbiol. [CD-RW], 2006
Born digital
320 - Electronic files, 2006
64 16
321 - RNase E maintenance of proper FtsZ/FtsA ratio required for non-filamentous growth of Escherichia coli cells but not for colony forming ability - J. Bacteriol., 2006
Born digital
321 - Electronic files, 2006
64 17-18
322 - Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes - Genes Dev., 2006
Born digital
322 - Electronic files, 2006
64 19
323 - rag genes: novel components of the RamR regulon that trigger morphological differentiation in Streptomyces coelicolor - Mol. Microbiol., 2006
Born digital
323 - Electronic files, 2006
65 1
324 - Phenotype-based identification of host genes required for replication of African swine fever virus - J. Virol., 2006
Born digital
324 - Electronic files, 2006
65 2
325 - Retention of core catalytic functions by a conserved minimal RNase E peptide that lacks the domain required for tetramer formation - J. Biol. Chem., 2006
Born digital
325 - Electronic files, 2006
65 3-5
326 - Human MDM2 isoforms translated differentially on constitutive vs. p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops - Mol. Cell. Biol., 2006
Born digital
326 - Electronic files, 2007
Born digital
327 - Characterization of a large, stable, high-copy-number streptomyces plasmid that requires stability and transfer functions for heterologous polyketide overproduction, 2007
65 6
328 - Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces - J. Bacteriol., 2007
Born digital
328 - Electronic files, 2007
Born digital
329 - Electronic files, 2008
Born digital
330 - Glioma cells on the run � the migratory transcriptome of 10 human glioma cell lines, 2008
65 7
331 - Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts - J. Bacteriol., 2008
Born digital
331 - Electronic files, 2008
Born digital
332 - Genomic expression profiling of TNF- -treated BDC2.5 diabetogenic CD4 T cells, 2008
Born digital
333 - Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: functional analysis of DNase I subdomain, 2008
65 8
334 - Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction - ACS Chem. Biol., 2008
Born digital
334 - Electronic files, 2008
65 9-10
335 - YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity - Genes Dev. [CD-R], 2008
Born digital
335 - Electronic files, 2008
65 11-12
336 - Identification of cellular genes affecting the infectivity of foot-and-mouth disease virus - J. Virol., 2009
Born digital
336 - Electronic files, 2009
Born digital
337 - A functional mouse retroposed gene Rps23r1 reduces Alzheimer's b-amyloid levels and tau phosphorylation, 2009
Born digital
338 - Microbial drug resistance: an old problem in need of new solutions, 2009
65 13-14
339 - Regulation of morphological differentiation in S. coelicolor by RNase III (AbsB) cleavage of mRNA encoding the AdpA transcription factor - Mol. Microbiol., 2010
Born digital
339 - Electronic files, 2010
Born digital
340 - Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in streptomyces coelicolor, 2010
Born digital
341 - The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's b-amyloid level and tau phosphorylation, 2010
65 15
342 - Heterodimeric integrin complexes containing Β1-integrin promote internalization and lethality of anthrax toxin - Proc. Natl. Acad. Sci. USA, 2101
Born digital
342 - Electronic files, 2011
65 16
343 - Regulation of transcription of hypoxia-inducible factor 1α (HIF-1α) by heat shock factors HSF2 and HSF4 - Oncogene, 2011
Born digital
343 - Electronic files, 2011
65 17-18
344 - Upregulation of RNase E activity by mutation of a site that uncompetitively interferes with RNA binding - RNA Biol., 2011
Born digital
344 - Electronic files, 2011
66 1-2
345 - Human genetic variation altering anthrax toxin sensitivity - Proc. Natl. Acad. Sci. USA, 2012
Born digital
345 - Electronic files, 2012
66 3
346 - Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein - Proc. Natl. Acad. Sci. USA, 2012
Born digital
346 - Electronic files, 2012
66 4
347 - Second site suppression of RNase E essentiality by mutation of the deaD RNA helicase in Escherichia coli - J. Bacteriol., 2012
Born digital
347 - Electronic files, 2012
Born digital
348 - Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R
66 5-7
349 - Spt4 is selectively required for transcription of extended trinucleotide repeats - Cell, 2012
Born digital
349 - Electronic files, 2012
Born digital
350 - Ribonuclease E modulation of the bacterial SOS response, 2012
Born digital
351 - Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis, 2012
Born digital
352 - Nutrient dependence of RNase E essentiality in Escherichia coli, 2013
Born digital
353 - Upregulation of the host SLC11A1 gene by clostridium difficile toxin B facilitates glucosylation of rho GTPases and enhances toxin lethality, 2013
Born digital
354 - Electronic files, 2013
Born digital
355 - Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis, 2013
Born digital
356 - Identification of TSG101 functional domains and p21 loci required for TSG101-mediated p21 gene regulation, 2013
Born digital
357 - Modulation of anthrax toxin uptake by DKK1, an antagonist of the Wnt co-receptor LRP6, 2014
Born digital
358 - Reversible vancomycin tolerance induced in Staphylococcus aureus by concurrent exposure to colistin, 2015
Born digital
359 - Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntington allele by Supt4h knockdown, 2015
Born digital
360 - Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting, 2015
Born digital
361 - RPS23RG1 reduces AΒ oligomer induced synaptic and cognitive deficits, 2016
Born digital
362 - PpsA?mediated alternative pathway to complement RNase E essentiality in Escherichia coli, 2016
Born digital
363 - Inactivation of host caspases by Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus, 2016
Born digital
364 - Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts associated with c9FTD/ALS, 2016
 
Unnumbered [subseries]:
66 8
SNC bibliography listing publications #1-78, 2 books, and 16 abstracts, 1977
66 9
Meacock/Cohen - Analysis of pSC101 replication and incompatibility using a composite replicon, undated
66 10
Further studies on the mechanism of action of chloroquine: inhibition of DNA and RNA polymerase reactions, undated
66 11
Klug, Cohen m.s. - data, undated
66 12
Delayed hypersensitivity in the hamster - produced and elicited with Freund's complete adjuvant: a preliminary report, c.1959-1960
66 13
GDH, 1963-1964
66 14
Nucleic acids - misc., 1964
66 15
Charts, 1966
66 16
Selectivity of in vitro RNA synthesis on lambda DNA templates, 1967
66 17
Genome construction between bacterial species in vitro: replication and expression of staphylococcus plasmid genes in Eschericiha coli, 1974
66 18
The organization of sea urchin histone genes, 1975
66 19
Basic research and the public interest - the public has the right to be assured that experiments are carried out safely, 1975
66 20
Covalently closed circular DNA molecules of low superhelix density as intermediate forms of plasmid replication, 1976
66 21
Genetic recombination through protoplast fusion in streptomyces, 1977
66 22
DNA cloning and the analysis of plasmid structure and function, 1978
66 23
Cloning and characterization of EcoRI and Hind III restriction endonuclease-generated fragments of antibiotic resistance plasmids R6-5 and R6, 1978
66 24
Instability of plasmid DNA sequences: macro and micro evolution of the antibiotic resistance plasmid R6-5, 1978
66 25
The transplantation and manipulation of genes in microorganisms, 1979
66 26
An unusual transposon with long terminal inverted repeats in the sea urchin strongylocentrotus purpuratus, 1983
66 27
The effect of charged amino acid exchange in the N-terminal domain. . ., 1989
66 28-29
Beaucage/Miller/Cohen, 1989-1991
66 30
Sue's paper, 1990
66 31
Effects on the formation of antenna complex B870 of Rhodobacter capsulatus by exchange of charged amino acids in the N-terminal domain of the α and Β pigment-binding proteins, 1990
66 32
Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300, 1999
66 33
Streptomyces, 1999
66 34
Foreword of "The Biotech Millennium", 2001
 
Unpublished [subseries]:
66 35
Brenner/Lin-Chao/Cohen - Using retrovirus-derived portable exon to clone and study mammalian regulatory genes - Methods in Enzymology article, 1991
66 36
Cohen and Christine Miller - Non-chromosomal antibiotic resistance in bacteria V. Recombination between an R-factor transfer unit and a chromosomal resistance determinant, undated
66 37
Gilbert/Ravnan/Cohen - Jackpotting does not contribute to density labelling results consistent with random replication ofm bovine papilloma virus in mouse fibroblasts, undated
66 38
Gilbert/TenHagen/Cohen - Integrated and extrachromosomal fomrs of a BPV/MMTV/RAS chimeric molecule have different replication patterns int ransformed mouse C127 cells, undated
66 39-41
Gustaffson and Meacock - Plasmid partition is not determining the incompatibility behaviour of a plasmid, 1980-1982
66 42
Gustafsson, Meacock, Cohen - Studies on plasmid pSE101 partition and incompatibility, 1982-1983
66 43
Interferon, 1980
66 44
Jaurin and Cohen - A transcriptional fusion vector that utilizes the ampC-[ ]-lactamase gene of Escherichis coli for the direct selection of up-mutants in gene expression, 1987
66 45
Jean Brevet studies - Insertion of replication regions and other endonuclease-generated DNA fragments into transposible genetic elements, 1975-1977
67 1
Miller/Cohen - The Cmp phenotype of the par locus of pSC101. How is it related to incompatibility and replication?, 1985-1986
67 2
Sininsky/Histone paper - Effects of upstream translation on the efficiency of translational starts on eukaryotic DNA cloned in E. coli: expression of S. Purpuratus histone H2V genomic DNA, 1980
67 3
Taylor/Sininsky - A novel series of E. coli cloning vectors, 1981
67 4
Troutt/Liebermann/Hoffman-Liebermann/Cohen/Kedes - Tissue-specific and regulated transcript accumulation of the pPu/pPy class of dispersed repetitive sequences, 1986-1988
67 5
Tu/Cohen - A novel regulatory gene which enhances Tn21 transposition and suppresses cointegrate resolution, 1984-1985
 
Series 7: Lectures and Presentations, 1977-2016 [series]:
 
Fear of Knowledge [subseries]:
67 6-7
1996-2000
Born digital
26 March 1995
Born digital
29 April 1998
Born digital
1 May 1998
Born digital
4 June 1998
Born digital
Handout, 22 September 1998
Born digital
22 June 1999
67 8
Merigan Lecture - Stanford, 10 October 2001
Born digital
Merigan Lecture - Stanford, 10 October 2001
Born digital
Albany Lecture, 2 May 2005
Born digital
Chinese University, Hong Kong, November 2005
2 6
"Role of translocating genetic elements and repeated DNA sequences in the structural evolution of bacterial plasmids" at Mechanisms of Resistance to Antibiotics round table - brochure, 6-7 November 1975
4
The V. D. Mattia lecture - Dr. Stanley Cohen [2 audiocassettes], 1977
 
Kinyoun Lecture - NIH, Bethesda, Md., 3 December 1981 [subseries]:
67 9
Correspondence, 3 December 1981
4
Cohen's lecture [reel-to-reel audiotape], 3 December 1981
67 10
Christmas lecture - University of Chicago, 5-6 December 1981
67 11
Danish Academy of Technical Sciences - Copenhagen, 17 May 1982
67 12
Chretien Montreal lecture - Montreal, 14 June 1982
67 13
University of Chicago lecture, 8 December 1982
67 14
George Washington University lecture - Washington D.C., 9 December 1982
67 15
CETUS-UCLA Symposium Gene Expression - Park City, UT, 26 March-1 April 1983
67 16
3-M Carlton Award ceremony - St. Paul, Minnesota, 4 May 1983
67 17
Ferring symposium - Stockholm, Sweden, 1-2 July 1983
67 18
Syntro - Stanford, 5-8 July 1983
67 19
Alexander von Humboldt Foundation lecture - Stanford, 29 August-1 September 1983
4
Von Humboldt Conference speaker Stanley N. Cohen [audiocassette], 31 August 1983
67 20
University of California Berkeley (UCB)-NBL International symposium, 7-10 October 1983
67 21
Stanford Medical and Scientific Highlights (SMASH) lecture - Stanford, 2 December 1983
67 22
Lenore Meadows Memorial Lecture - Queens College, N.Y., 24 April 1985
67 23
3rd International Conference on Genetics and Biotechnology of Bacalli - Stanford, 15-17 July 1985
67 24
mRNA stability as a control mechanism in gene expression - NIH lecture, 1987
67 25
Univ. of Texas Health Science Center lecture series - Dallas, Texas, 17-18 February 1988
4
Cohen lecture [audiocassette], 26 April 1988
67 26
The Russell Marker Lectures in Genetic Engineering - Penn State University, 27-29 April 1988
67 27
NIH lecture - Bethesda, Md., 28 September 1988
67 28
"Analysis of Mammalian Gene Regulation in situ Using Retrovirus-Based Portable Exons" - National Institutes of Health Lectureship program and certificate, 20 September 1989
67 29
University of Pennsylvania talk, 1990
67 30
Roy Clowes Memorial Lecture - University of Texas, Dallas, Tx., 8 November 1990
67 31-32
University of California San Francisco (UCSF) / Exploratorium Symposium on the Recombinant DNA Revolution in Biology - Auditorium of the Palace of Fine Arts, San Francisco, 25-26 September 1992
Born digital
University of California San Francisco (UCSF) / Exploratorium Symposium on the Recombinant DNA Revolution in Biology - Auditorium of the Palace of Fine Arts, San Francisco, 25-26 September 1992
67 33
University of Pennsylvania Biomedical Research Building I (BRB1) groundbreaking - Philadelphia, 5-6 October 1992
Born digital
University of Pennsylvania Biomedical Research Building I (BRB1) groundbreaking - Philadelphia, 5-6 October 1992
67 34
Kornucopia: A Celebration of David Korn - text and program, 11 March 1993
67 35
K.T. Li Symposium - Taipei, Taiwan, 1 November 1995
67 36
Cobiotech: North-South America Conf. on Biotechnology - Cuernavaca, Mexico, 26-29 November 1995
67 37
Melville Hare Memorial Lecture, 5 December 1995
67 38
Charles R. Ross Seminar - University of Syracuse, 6 December 1995
67 39
Harvard Med School lecture, 23 April 1996
67 40
Chang Gung Medical College - Taiwan, 24 May 1996
67 41
Smithsonian Lecture, 5 October 1996
96
American Society for Microbiology Division H Lecture at the 98th ASM General Meeting - plaque, 18 May 1998
67 42
Rockefeller University lecture, 27 October 2000
Born digital
"The Road from the Double Helix to DNA Cloning" at Scientific Symposium: From Double Helix to Human Sequence-and Beyond - NIH, Natcher auditorium, 14 April 2003
4
"Deciphering Nature's Alphabet: a Conversation" - National Human Genome Research Institute [vhs videocassette], 14 April 2003
Born digital
Society for General Microbiology: Fred Griffith Prize Lectureship - Manchester, U.K., 8-11 September 2003
Born digital
Scripps lecture, October 2006
Born digital
Berkeley symposium talk, April 2008
Born digital
Pioneers in Science lecture - Stanford, 10 March 2010
3 16
"Being a scientist: A personal history of the invention of recombinant DNA and the start of biotech" at the Academia Sinica in Taipei, Taiwan - brochure [in Newspaper and magazine clippings, press releases, brochures 2001-2013], 10 December 2010
Born digital
Baylor College of Medicine talk - Houston, Tx. - cancelled, 11 March 2014
Born digital
Guest lecture in Genetics 216, 6 May 2016
 
Series 8: Genetics Department, 1976-2008 [series]:
67 43
Faculty - Biochemistry 201, 1976
 
Clinical Pharmacology/Medicine 202 [subseries]:
67 44
Antibiotic resistance, 1979-1986
67 45-46
Courses, 1980-1996
67 47
Drug Interaction/adverse drug reactions, 1977
67 48
Lecture, January 1987
68 1-2
Notes, 1970-1979
68 3-5
Genetics lecture on "DNA Recombination", 1977-1991
68 6
Genetics lecture on "DNA Repair" - handouts, undated
68 7-11
Genetics lecture on "Genes and Drugs" - lecture notes, 1978-1991
68 12-15
Genetics lecture on "Human Gene Therapy" - Gene Therapy/Ethics, 1983-1992
68 16-18
Genetics lecture on "Pharmacogenetics and Teratogenecity" - lecture notes, 1978-1985
68 19-21
Genetics lecture on "Transposable Elements", 1980-1985
68 22
Genetics seminars/colloquiums, 1989-1998
 
Genetics 201/202 Human Genetics [subseries]:
68 23
Committee on Courses and Curriculum (CCC), 1981-1986
68 24
Copyright policies, 1989-1993
68 25
Correspondence with outside lecturers, 1982-1987
68 26-27
Course evaluations, 1981-1987
68 28
Final exam questions, 1979-1987
68 29
Mid-term exam questions, 1985
68 30
Miscellaneous correspondence, 1981-1988
68 31
Placement exam questions, 1984-1985
68 32
Qualifying exam, 1984-1986
68 33
Genetics 201 syllabus - winter quarter, 1987
69 1
Genetics 201 - class handouts, January 1989
69 2-4
Genetics 201, 1990-1991
69 5
Genetics 202, 1990
 
Genetics 208 [subseries]:
69 6-7
Background material, 1998-2008
69 8-9
Ethics, 1995-1999
69 10
March 3, 1998
69 11
Winter 1999 - Data and data interpretation, 2002-2003
69 12
Winter 1999 - loose papers, 1998-1999
69 13
Evaluations, 1999
69 14-15
Winter 2001, 2001-2003
69 16
Lecture 1 - Overview, 10 January 2001
69 17
Lecture 2 - Authorship and peer review, 17 January 2001
69 18-20
Lecture 3 - Scientific error and misconduct, 24 January 2001
69 21
Lecture 4 - Intellectual Property and Patents, 31 January 2001
69 22
Winter 2003, 2003
 
Genetics 209 - Vision and Vision Disorders [subseries]:
69 23
Evaluations, 1994
69 24-26
Literature for eye course, 1991-1997
69 27
Spring 1990
69 28
Vision and Vision Disorders, 1994
69 29
Vision and Vision Disorders, 1997
69 30
Genetics 214, 1990-1991
69 31
Genetics 217, 1994
69 32
Medical microbiology, 1977
 
Pharmacology [subseries]:
69 33
Ethics, undated
69 34-35
Miscellaneous lecture notes and handouts, 1981-1990
69 36
Steroids, undated
69 37
Pharmacology 209, 1981
 
Miscellaneous Course Outlines [subseries]:
70 1
Miscellaneous course outlines, 1981-1987
70 2
Cell minireview - original artwork, 1995
70 3
Molecular Matters lectures, 1995
 
Postgraduate Medical Education [subseries]:
70 4
Miscellaneous, 1985
70 5
Antibiotic resistance, 1980-1983
70 6
Basic science for clinicians, 1983-1984
70 7-8
Recombinant DNA I, II, 1970-1983
 
Series 9: Contracts and Grants, 1967-2010 [series]:
 
American Cancer Society [subseries]:
70 9
American Cancer Society, 1979-1982
 
MV-44N - Etiology and Evolution of Plasmids [subseries]:
70 10
Reports, unknown date
70 11-30
Reports, 1971-1990
70 31-32
MV-44Q - Etiology and Evolution of Plasmids, 1 January 1991-31 December 1992
70 33
NP-834R - Etiology and Evolution of Plasmids [3.5 computer disc], 1 January-31 December 1993
 
California Breast Cancer Research Program (BCRP) - BCRP 6JB-0008 [subseries]:
70 34-35
[untitled][zip disc], 2000-2003
71 1
[untitled], January 2000
71 2
Annual progress report, June 2001
 
California Cancer Research Program (ovarian cancer) - 99-00504V-10066 [subseries]:
71 3-5
California Cancer Research [zip disc], 1998-2002
71 6
Annual reports, 2001-2001
71 7-11
Progress reports, 1999-2002
 
California Cancer Research (prostate cancer) [subseries]:
71 12
California Cancer Research, 1999-2000
71 13
Application [zip disc], 2001-2003
71 14
CPR ID 1II00066, 1998-2001
71 15
Computer-based consultations in clinical therapeutics 1977-1980, 1978
 
Defense Advanced Research Projects Agency (DARPA) [subseries]:
71 16-21
General, 1997-2003
71 22-24
Defense Advanced Research Projects Agency (DARPA) [zip disc, CD-RW], 1999-2006
72 1-6
Defense Advanced Research Projects Agency (DARPA) [zip disc, CD-RW] (cont'd), 1999-2006
72 7-9
Defense Advanced Research Projects Agency (DARPA) I, 1997-2001
72 10-12
Defense Advanced Research Projects Agency (DARPA) II JCR65 stats, 2000-2001
72 13-14
Defense Advanced Research Projects Agency (DARPA) III, 2002-2004
72 15-16
Collaboration - McAdams, Harley - Defense Advanced Research Projects Agency (DARPA) proposal, 1995-2003
72 17
Host Oriented Therapeutics (HOT), 2002
72 18
Genetic Regulatory Networks - MDA972-00-1-0032-A00002 - final report, 31 May 2004
 
Defense Advanced Research Projects Agency (DARPA) Toxins in Mammals Grant N65236-99-1-5425 [subseries]:
72 19
"Creating cellular resistance to toxins in mammals", 2000
72 20
Milestone update, February 2001
72 21
Annual report, 17 March 1999-16 March 2000
72 22-40
Quarterly Reports, 1999-2004
 
Defense Advanced Research Projects Agency (DARPA) Viral Pathogens Grant [subseries]:
72 41
General, 2000-2003
72 42
References, undated
73 1
Swine subproject, 2001
73 2
Unconventional Concepts, Inc., 2004
73 3
Interim progress report, 1 January-31 July 2004
73 4-17
Quarterly Reports, 2001-2004
 
Department of Energy [subseries]:
73 18
Genome to Life, 2002
73 19
Human genome program, 1993
73 20
DTRA attenuation / Genes and Mechanisms Underlying Microbe-Mediated Attenuation of the Host Innate Immune Response, 2009-2010
 
Ellison Medical Foundation / Genetic Mechanisms Regulating Aging in Differentiated Human Cell Populations [subseries]:
73 21
General, 2002-2007
73 22
Grant application, 2002
73 23-25
Annual reports, 2003-2005
73 26
FDA 223-74-3197, 1 September 1974-
 
Funding Opportunities [subseries]:
73 27
General, 1988-1993
73 28
American Lung Association of San Francisco - medical research grants, 1989
73 29
Bank of America - Giannini Foundation, 1991
73 30
Cancer biology postdoctoral application, 1985
73 31
Cancer Research Institute, 1988
73 32
Cooperative Breast Cancer Tissue Registry (CBCTR) - request proposal, 1996
73 33
Department of Commerce - Office of Competitive Technology Grants, 1988-1993
73 34
Department of the Navy Research Grants for Investigation of Bioremediation of Hazardous Wastes in Marine Environments, 1990
73 35
Government funding sources (SPO newsletter), 1990-1991
73 36
Howard Hughes Medical Institute - grants and special programs, 1993
73 37
Human Frontier Science Program (HFSP) - Japan - grants and fellowships, 1989
73 38-39
Johnson and Johnson Focused Giving, 1992-1995
73 40
Life Sciences Research Foundation (LSRF), 1982
73 41
Lucille P. Markey Charitable Trust, 1985-1994
73 42
March of Dimes, 1986
73 43
Katharine McCormick Fund for Women, 1993-1994
73 44
National Eye Institute - Institutional National Research Service Award, 1990
73 45
NCI Outstanding Investigator's Grant, 1984-1986
73 46
NIAID Minority Research Enhancement Program, 1988
73 47
NIGMS MARC Honors Undergraduate Training Program, 1986
73 48
NIGMS research reports, 1988-1994
73 49
Pew Latin American Fellows Program, 1993
73 50
Program in Molecular and Genetic Medicine (PMGM) research grants, 1989
73 51
Rhone-Poulenc Rorer Pharmaceuticals sponsored research program, 1997
73 52
University of California - Tobacco-related Disease Research Program Awards, 1991
73 53
Wellcome Trust, 2003
 
Grand Challenges in Global Health / Combating Drug-Resistant HIV, TB, and Malaria by Host-Oriented Therapeutics [subseries]:
73 54-56
General, 2003-2004
73 57
Jetsumon Prachmsri (nee Sattabongkot), 2004
73 58
Mentor - original proposal, 1 March 1984
 
Miscellaneous Applications/Grants [subseries]:
73 59
The Breast Cancer Research Foundation, 1997
73 60-61
Drafts, 1992-1994
73 62
Lung cancer, 1999
73 63
Research incentive funds, 1995
73 64
Sponsored project routing form, 1994-1998
73 65
NASA Microgravity Biotechnology, 1991
 
NIH [subseries]:
73 66
Grants, 1987-1993
73 67
Modular grant information, 1998
73 68
National Institute on Aging Research - training opportunities, undated
74 1-25
NIH AI 08619 - Genetic Mechanisms in Bacterial Antibiotic Resistance - Reports, years 1 through 26 [year 16 missing], 1967-1982
74 26
NIH AI 10562-01 - The Replication and Transfer of R-Factors, 1 September 1971-
74 27
NIH AI 11697-01 - Evolution of R-Factors and Other Bacterial Plasmids, 1 September 1973-
74 28
NIH AI 24779 (RCDA) - Genetic Control of Non-Chromosomal Drug Resistance, 1967-1973
74 29-30
NIH CA 87618 - Genes that Suppress Metastasis of Prostate Cancer, 1999-2002
74 31-34
NIH EY 07106 - National Eye Institute Training Grant - Genetics - reports, 1988-1991
 
NIH GM 00295 - Genetics [subseries]:
74 35
General, 1979
74 36-42
Reports - years 1-15, 1978-1991
75 1-4
Reports - years 1-15 (cont'd), 1978-1991
75 5
NIH GM 08404 - Postdoctoral Training Program in Medical Genetics, 1990
 
NIH GM 26355 - Propagation and Inheritance of Plasmids [subseries]:
75 6-8
General, 1984-1991
75 9-31
Reports - Years 1 through 17 [years 6 and 10 are missing], 1979-1999
75 32-39
NIH GM 27241 - Gene Expression in Heterospecific Environments - reports, years 1 through 14 [year 7 missing], 1 July 1985-30 June 1990
76 1-8
NIH GM 27241 - Gene Expression in Heterospecific Environments - reports, years 1 through 14 [year 7 missing] (cont'd), 1 July 1985-30 June 1990
 
NIH GM 42930 - New Approaches for Genomic DNA Cloning and Analysis [subseries]:
76 9-10
Background material, 1986-1989
76 11-12
GM 42930-01, 1988-1990
76 13
NIH GM 54158 - Polyadenylation of RNA in Bacteria, 2002
 
NIH HG 00325 - New Approaches for Genomic DNA Cloning and Analysis [subseries]:
76 14
Human Genome Project, 1995
76 15
Background material, 1988-1991
76 16
Supplemental equipment, 1989-1991
76 17-18
Report 2 and 3 [report 1 is missing], 1990-1993
76 19
NIH Genome grant, 1 April 1992-31 March 1995
 
NIH HS 00739 - Mediphor / Computer-based On Line Drug Therapy Monitoring System [subseries]:
76 20
Alverno Admin. Services, 1981
76 21-22
Becton Dickinson, 1975-1976
76 23
Cohen/Armstrong book, 1973-1976
76 24-25
Drug interaction minutes, 1971-1977
76 26-27
Early days, 1969-1973
77 1
Facts and comparisons (book), 1983-1984
77 2
GAO audit, 1974-1975
77 3-4
Grant - 00739, 1974-1981
77 5-6
Hospital audit I and II, 1971-1978
77 7
Hospital Blue Cross reimbursement, 1970-1976
77 8-11
Hospital computer system I-IV, 1970-1985
77 12
IBM, 1984
77 13-14
Indiana evaluation, 1976-1979
77 15
Inquiries, 1984-1985
77 16
Interaction review, 1983-1986
77 17
Installation manual, 1981
77 18-19
Mario Negri Institute, 1971-1976
77 20-21
Medicus, 1976-1979
78 1-4
Program documentation, undated
78 5-6
Project documentation, 1972-1973
78 7-8
References, 1971-1982
78 9
Report, 1978-1995
78 10
Reprints, 1980-1984
78 11
Space (trailer), 1971-1985
78 12
Technicon - El Camino, 1975
78 13
Trademark, 1985-1987
78 14
Walter Reed Medical Center, 1980
78 15-20
Years 1 through 6 reports, 1971-1980
78 21-25
NIH HS 01544 - Mycin, 1973-1980
79 1-5
NIH HS 01544 - Mycin (cont'd), 1973-1980
 
NIH HS 03000 - Minerva / Computer Intervention in Clinical Drug Therapy [subseries]:
79 6
AMA system, 1983
79 7-9
Correspondence I and II, 1977-1987
79 10-11
Evaluation, 1977-1979
79 12-13
Final report I and II, 1982-1987
79 14-15
Progress report 1, 1 December 1977-30 November 1978
79 16
Rules, 1979-1983
 
NIH TSG101 - Tumor Suppression Gene [subseries]:
79 17-19
General, 1996-2001
79 20-21
NIH grant application - pending, 1 February-1 October 1997
79 22
NIH RR 00785 (Sumex), 1978
 
National Science Foundation [subseries]:
79 23-24
GB 30581 - Replication and Transfer of R-Factors, 1971-1981
79 25
PCM75-14176, PCM77-21058 - Replication and Transfer of R Plasmids, 1973-1980
80 1-4
PCM75-14176, PCM77-21058 - Replication and Transfer of R Plasmids (cont'd), 1973-1980
80 5-6
Role of mRNA Stability in Genetic Control, 1 July 1986-30 June 1991
80 7
PAR project, 1984-1985
80 8
Other Material - NIH Study Section posters, 1994-1999
80 9
Unfunded Proposals - FIRCA - Gaggero/Cohen, 1996-1997
 
Series 10: Material Transfer Agreements, 1968-2006 [series]:
 
Plasmids/Strains [subseries]:
80 10
Materials sent, 2000-2001
80 11
MTA, 1992-1997
80 12
MTAs for Cohen lab material, 2001-2002
80 13
MTV, 1997-1998
80 14
PharMingen, 1992-1993
80 15-18
Plasmid nomenclature, 1968-1976
80 19-20
Plasmid reference center, 1976-1983
80 21
Procedures, 1982
80 22-24
Requested by Cohen Lab, 1978-2002
80 25
Requests denied or unavailable to send, 2001
80 26-30
Strains sent, 1974-1994
81 1-12
Strains sent (cont'd), 1974-1994
99 1
Miscellaneous plasmid data, 1969
99 2
Miscellaneous plasmid data, 1973
99 3
Plasmids/strains – lists, 1974-1983
99 4
Plasmids/strains – hold for signed letter, 1983-1986
 
Random Homozygous Knockout (RHKO) [subseries]:
81 13
Request/offer document, 1999-2006
81 14-36
A-Z, 1999
81 37
Usefulness inquiry - responses, 1992
81 38
Research services, 1995
 
Series 11: Cohen/Boyer Patent: Process for producing biologically functional molecular chimeras, 1972-2003 [series]:
95 1
Cohen/Boyer original patent certificate, 1980
95 2
Cohen/Boyer patent copies and photograph of Cohen/Boyer at ceremony [photograph], 1980
95 3
Cohen/Boyer patent information, 1974

Unsigned letter dated November 21, 1974 from SNC, "Associate Professor Head, Division of Clinical Pharmacology" to Bertram I. Rowland; text: addresses enclosed for Annie Chang, John Morrow and Charles Yanofsky; "I must ask that you state in your covering letter to the co-authors that rights to the invention have been (will be?) assigned to Stanford University and the University of California. As we have discussed previously, I am eager to avoid any misinterpretations by colleagues of my motives in agreeing to assist Stanford in proceeding with obtaining a patent for this invention. Your disclaimer statement makes no mention whatsoever of Stanford or UC, and gives the impression that Berg [sic] and I are proceeding (for self profit?) obtaining a patent on this process for our own use."

Signed, undated letter from Bertram I. Rowland to SNC, at top right of page is handwritten "11/4/74" [there is no horizontal line through the number 7, so not by SNC, and November 4, 1974 is the filing date of the original patent application] and also at top right of page "File -- SN Cohen" handwritten by SNC; text of letter: "Enclosed please find Amendment" to patent application; attached seven-page AMENDMENT is dated "June 9, 1975 . . . . In response to the Office Action of March 31, 1975, please make the following amendments . . . ." signed by Bertram I. Rowland, no date on signature [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974]

Signed memo dated October 18, 1974 from Niels Reimers to Russ Meyer, cc SNC, "Reimers file" handwritten by SNC at top right of page; text: "Professor Stanley Cohen, Clinical Pharmacology, has offered to make a donation of the share of royalty income which he would otherwise receive from licensing of the gene transplant process. Professor Cohen's desire would be to have the income allocated to a medical research fund in memory of his father. can you please advise me how Professor Cohen's most generous offer may be handled so that he can at least receive a tax benefit. . . ."

Signed memo dated October 18, 1974 from Niels Reimers to Bill Carpenter, "SN Cohen" handwritten by SNC at top right of page; contents are catalogued in Row 374

Unsigned letter dated September 26, 1974 from SNC to Burt Rowland [sic]; text: "I have enclosed copies of papers describing clinical use for the antibiotic inactivating enzymes synthesized by R factors. In reviewing the situation, I find that the enzyme used clinically for assaying serum kanamycin levels as well as gentamycin levels, is made by the gentamycin resistance determinant on this R factor. Unfortunately, I haven't been able to find a specific clinical paper describing use of the kanamycin monophosphotransferase enzyme clinically, or use of the streptomycin inactivating enzyme clinically (these are two genes that we've put into E. coli). However, if necessary we could very easily put in a gentamycin resistance gene to make the enzyme used in these clinical studies. I would prefer to stick with what we have if possible.. Solution used for the shearing experiment was TEN buffer . . ."; no attachments to letter in file

Four copies of unsigned letter dated September 6, 1974 from SNC to Dick Roblin, Massachusetts General Hospital; text: "I had intended to include a copy of this memo with the letter I sent to you yesterday. It indicates the voluntary restrictions that have been observed in distribution of the pSC101 plasmid. Also, I have just been told by a reliable source that Miles Laboratories is now including a "warning" with all shipments of restriction enzymes, stating that the enzyme is sold under conditions that it will not be used for the "introduction of any viral genes" (?? T4?) or "any antibiotic resistance genes" (wow!) into bacteria. The "warning" indicates that the Miles policy is a response to the published recommendations of the NAS Committee."; no attachments to letter in file

Three copies of unsigned letter dated September 5, 1974 from SNC to Dick Roblin, Massachusetts General Hospital; letter contents are catalogued in Rows 64 and 285

Signed two-page letter dated November 15, 1974 from Bertram I. Rowland to SNC and Herbert W. Boyer; text: "necessary to obtain a disclaimer of invention from the co-authors. Accompanying this letter is the type of disclaimer which will be forwarded to each of the co-authors", asks for latest address for Annie C.Y. Chang, John F. Morrow, Howard M. Goodman, Robert B. Helling, Vickers Hershfield, Charles Yanofsky, Michael A. Lovett, and Donald R. Helinski, "Also, if you wish, I could forward to you my cover letter and the disclaimer, so that you might add additional remarks should you so chose [sic]. My cover letter will explain the situation to the co-authors, so that they will understand that they are not foregoing any scientific recognition, but rather that they do not fulfill the requirement of an inventor under the Patent Law. . . ."; attachment: two-page "DISCLAIMER"; text: "I, [ ], do hereby declare as follows: I am a co-author of the following publications: I have reviewed the claims of the subject application and do not believe that I am an inventor of the inventions claimed. . . ."

Letter dated September 17, 1974 from Josephine Opalka, not signed but stamped in signature space: "ORIGINAL SIGNED BY JOSEPHINE OPALKA" to Stefano Vivona, American Cancer Society, Inc., cc Stanley Bateman, Herbert W. Boyer, Sue Clark, Niels Reimers, stamped at bottom "STANFORD UNIVERSITY SEP 18 1974 TECHNOLOGY LICENSING", in upper right corner, "xcc Cohen Latker" handwritten and "File -- Reimers" handwritten by SNC, "Re: ACS Grant No. NP-112-B (Goodman) A PROCESS FOR CONSTRUCTION OF BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS--Cohen-Boyer"; text: "Thank you for your letter of September 12, 1974 in which you reported to me the Society's decision to permit disposition of the referenced invention in accordance with the policy and practices of the Department of Health, Education and Welfare. . . ."

Signed memo dated September 4, 1974 from Bill Carpenter to SNC, "Reimers file" handwritten by SNC near top of page; text: confirms their meeting on September 11, "As I mentioned, we are investigating the commercial potential of the gene transplant process, which will guide us in our licensing efforts. Our focus should therefore be on what developments will be necessary before the process could ever be commercially applied, and what those applications might be. Further, we will also want to carefully consider the situation in light of recent questions that have been raised as to potential hazards of future experimentation . . . . After our meeting, I plan to visit Dr. Boyer at U.C.S.F. to get his thoughts on these questions as well."

Small, signed handwritten note dated August 28, 1974 from Niels Reimers to SNC; text: "Stan Attached are resumes of Bert Rowland and Mike Zimmerman (and Mike's former associates Dubb & Moore). . . ."; stapled behind note are four resumes: 1) Bertram I. Rowland (one page), with "Reimers file" handwritten by SNC 2) Hubert E. Dubb (four pages), 3) C. Michael Zimmerman (two pages), and 4) Gerald L. Moore (three pages)

Signed letter dated August 22, 1974 from Stefano Vivona, American Cancer Society, Inc. to Josephine Opalka, above text is stamp "RECEIVED AUG 26 1974 BOARD OF PATENTS", near top of page is handwritten "copy -- Niels Reimers", at bottom left of page is stamp "STANFORD UNIVERSITY AUG 29 1974 TECHNOLOGY LICENSING", in top right corner of page are "xcc Cohen Kirk fS74-" and handwritten by SNC "Reimers file"; text acknowledges receipt of her August 19, 1974 letter to Dr. Mason, "Your request has been forwarded to our legal representatives for a decision. . . ."

Unsigned letter dated August 21, 1974 from Clive S. Liston, Patent and Copyright Manager to Jesse E. Lasken, National Science Foundation, cc SNC, H.J. Latker, J. Opalka, N.J. Reimers, "Reference: Grant No. GB 30581, Subject: Invention Disclosure S74-44; text: "Enclosed is a copy of the subject invention . . . mentions support for the research from Stanford, University of California, National Institutes of Health, American Cancer Society "as well as the National Science Foundation. Since the National Institutes of Health appears to be the predominant interest agency, Stanford has elected to file a patent application pursuant to the DHEW/Stanford Institutional Patent Agreement.", Reimers "is arranging for the appropriate clearances and releases, and will contact you regarding further action."

Unsigned letter dated August 20, 1974 from Clive S. Liston, Patent and Copyright Manager to Norman J. Latker, Department of Health, Education and Welfare, cc SNC, J.E. Lasken, J. Opalka, N.J. Reimers, "Reference: Grant No. 5 R01 AI08619, Subject: Invention Disclosure S74-44; text: "Enclosed is a copy of the subject invention . . . mentions support for the research from Stanford, University of California, National Institutes of Health, National Science Foundation, and American Cancer Society, "The National Institutes of Health is believed to be to be the predominant interest agency in this case, and Stanford has elected to file a patent application pursuant to the DHEW/Stanford Institutional Patent Agreement.", Reimers "is arranging for the appropriate clearances from the University of California and the National Science Foundation, and will contact you regarding further action."; attachment stapled behind letter is catalogued in next row

Stapled to August 20, 1974 letter from Clive S. Liston is p. 2 of a signed letter dated August 20, 1974 from Niels J. Reimers to Norman J. Latker, Department of Health, Education and Welfare, cc SNC, J.E. Lasken, R.P. Mason, J. Opalka; text of p. 2 "By a copy of this letter, the NSF, which also has been provided the invention disclosure, is asked to release its interest to the NIH and that the NIH administer the invention on behalf of the Government, in view of the lesser support of the NSF. Because of the tremendous significance of this invention, we will plan to immediately proceed to file a patent application, particularly in view of the early publication in November 1973. It was not until this May, however, that the implications of this invention were realized by the scientific community. We intend to exercise great care in the administration of this invention, insofar as is feasible within the constraints of the patent grant which may be issued, to ensure against misuse of the invention. They key to protection against misuse, however, is not related to patent rights. It is the restraint that individuals of the international scientific community must exercise against uncontrolled experimentation. . . . "

Page one of a signed, two-page letter dated August 20, 1974 from Niels J. Reimers to Norman J. Latker, Department of Health, Education and Welfare, cc SNC, J.E. Lasken, R.P. Mason, J. Opalka, "Reimers file" handwritten by SNC in upper right corner of page; text of p. 1 "Re; NIH Grant: AI 08619", you already have received the invention disclosure, "We hereby elect to administer the invention pursuant to the University's Institutional Patent Agreement. There are some modest complications of which you should be made aware.", details collaboration with Boyer and all other sources of funding besides NIH, have requested other funders to release their patent rights to NIH and permit NIH to administer, mentions "attached letter of August 19, 1974 from Ms. Josephine Opalka" re UC agreeing that Stanford can administer patent if UC gets a release from ACS; no attachments to letter in file

Unsigned two-page letter dated August 20, 1974 form Niels J. Reimers to Norman J. Latker, DHEW; this document contains both pp. 1 and 2 of the letter catalogued in two previous rows

Unsigned letter dated August 2, 1974 from Niels J. Reimers to Josephine Opalka, cc SNC, "N Reimers file" handwritten by SNC at top right of p. 1; text: thanks for July 30 letter, gives "My recommendation for handling the situation with respect to the various research sponsors . . . .In so far as the appropriate arrangement between Stanford and U.C., I propose that royalties, if any be split equally between U.C. and Stanford after deducting a percentage that we can agree upon to cover patent filing and licensing expenses of Stanford."; this appears to be the letter Opalka referred to in her letter to Reimers of July 11, 1975, the latter is catalogued in Row 384

Signed letter dated June 26, 1974 from Niels J. Reimers to Josephine Opalka, cc SNC, "Reimers N set up file" handwritten by SNC in top right corner; text: enclosed is copy of disclosure no. S74-44, "Dr. Cohen has advised me that he does not plan to claim any royalties to which he would be otherwise entitled according to NIH and Stanford policy. Dr. Cohen understands that appropriate steps with regard to possible patent protection may be in order to ensure this work is developed for public use and benefit because, as you are aware, it is difficult to encourage development of new processes or other inventions without some form of proprietary protection to encourage a company to invest risk capital in development of new products or processes for the public. . . .", have to promptly disclose invention to NSF and HEW, "I ask that you give me an early call after you have had a chance to discuss the disclosure with Dr. Boyer."

Stanford University Invention Disclosure, SEL Form No. 207; submitted, signed, and dated by SNC on June 24, 1974, "Title A Process for Construction of Biologically Functional Molecular Chimeras Inventor/s S.N. Cohen, H.W. Boyer", "RECORDS (a) Conception Discussion between S.N. Cohen and H.W. Boyer, Plasmid Meeting Hawaii, November 1972. Follow up discussions early 1973. Put in SNC grants January & Feb. 1973. (b) Construction/tests/useage [sic] Experiments - winter & spring of 1973. (c) Publications/notes 1) Nov. 1973 -- PNAS 70, 3240. Construction of Biologically Functional Bacterial Plasmids in vitro 2) April 1974 -- PNAS 71, 1030. Genome Construction Between Bacterial Species in vitro 3) May 1974 -- PNAS 71, 1743. Replication of Eukaryotic DNA in E. coli (d) Oral Disclosures Many seminars and oral presentations from December 1973. Also symposium presentations - to be published. ATTACHMENTS Reprints of Papers 1 & 2 & 3"

Unsigned letter dated October 29, 1973 from SNC to Robert Helling, University of Michigan, "PATENT - COHEN BOYER" handwritten by Karen Carpenter at top of page; text: "I have enclosed negatives I used in making slides covering the material in our PNAS paper. . . . I'm sure these will be satisfactory for your needs. Things here are moving well as we try to pull data together for the Xenopus story. I'm interested in learning just how many partial digest plasmids you have run through in checking for one with an intact ribosomal DNA sequence. We've been through only 5, and haven't found even a pSC101 with any ribosomal DNA on it --- let alone an intact repeat sequence. I would appreciate your sending these negatives back to me just as soon as your photographer completes your slides."

Undated two-page form letter from Bertram I. Rowland, cc SNC and Herbert W. Boyer, "Cohen/Boyer" handwritten at top of p. 1, SNC handwrote "File - Reimers" in upper right of p. 1; contents same as January 28, 1975 form letter catalogued in Row 152 [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974].

Stanford University Patent Agreement, Form SU-18, signed and dated by SNC on September 1, 1972; folded with it is photocopy of "Page 1 of 2 Pages" of unsigned ASSIGNMENT form [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 312, 355, and 366]

41-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", ". . . This application is a continuation-in-part of application Serial No. 687,430 filed May 17, 1976 which was a continuation-in-part of application Serial No. 520,691, filed November 4, 1974, now abandoned.", contains 10 claims; attached to it is unsigned two-page DECLARATION AND POWER OF ATTORNEY [signed version of form catalogued in Row 312 and older signed version of slightly different form (only 13 lawyers listed) catalogued in Row 355]; [These documents seems to be filed in the wrong folder. The contents are from 1976 or later, not 1974].

Butterfly clamp holding nine items: 1) USPTO Office Action, from A. E. Tanenholtz to Townsend & Townsend, stamped "RECEIVED APR 5 1975 TOWNSEND AND TOWNSEND", "This application has been examined."." Part I, "Notice of References Cited, Form PTO-892." [this Notice is not in the file], Part II, "SUMMARY OF ACTION Claims 1-9 are allowed. . . . Claims 10-26 are rejected."; "PATENT - COHEN BOYER" handwritten by Karen Carpenter at top of page; [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974].

Butterfly clamp holding nine items, continued: 2) undated "NOTIFICATION OF REJECTION(S) AND/OR OBJECTION(S) (35 USC 132)", detailing opinion on Claims 10-26, stamped "ALVIN E. TANENHOLTZ EXAMINER ART UNIT 172"; [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974].

Butterfly clamp holding nine items, continued: 3) 14-page "Brief Biography of Scientific Contributions Relating to Recombinant DNA (in historical perspective)", "Patent office File" handwritten by SNC at top of p. 1; extensive handwritten edits by SNC of the bibliographic details of the references; [This document seems to be filed in the wrong folder. It cites references as recent as 1978].

Butterfly clamp holding nine items, continued: 4) 14-page "Brief Biography of Scientific Contributions Relating to Recombinant DNA (in historical perspective)", small handwritten edits by SNC to text on pp. 11-12; [This document seems to be filed in the wrong folder. It cites references as recent as 1978].

Butterfly clamp holding nine items, continued: 5) photocopy of New Scientist, July 8, 1982, p. 75, containing article, "Genetic engineers stitched up over patent rights" by Paula Dwyer; "Patent file" handwritten by SNC at top right of page

Butterfly clamp holding nine items, continued: 6) photocopy of New Scientist, November 4, 1982, p. 277, containing article, "Stanford battles for cash from DNA patent . . ." by Paula Dwyer; "Patent file" handwritten by SNC at top right of page

Butterfly clamp holding nine items, continued: 7) photocopied pages from book, Recombinant DNA: The Untold Story by John Lear, Crown Publishers, Inc., New York, 1978; a) pp. 69-70, with "Cohen - Boyer patent file" handwritten by SNC at top of p. 69, b) pp. 83-85, c) copy of inside cover with title

Butterfly clamp holding nine items, continued: 8) one-page "CORRECTION TO SENATE REPORT NO. 9", signed by Erin Hutchinson, who wrote "Prof. Cohen" at top right, below it "Patent" handwritten by someone else, and below them "File" handwritten by SNC; text: "In Senate Report No. 9, published in Campus Report of March 9, 1977, it was reported that Professor S. Cohen and a Berkeley colleague had filed a patent application following a disclosure arising from work in the field of recombinant DNA. That Report should have said that Stanford University had filed a patent application following a disclosure arising from work on recombinant DNA which had been carried out by Professor S. Cohen and Professor H. Boyer, University of California at San Francisco."

Butterfly clamp holding nine items, continued: 9) undated handwritten note, "Pat, from Esther", clipped in front of six handwritten pages listing people who had requested pSC101 between 1973 and 1982 and "S.N. Cohen Lab Cultures Contrib. Directly or Indirectly to PRC" between 1976 and 1982

95 4
Cohen/Boyer patent information, 1975

Signed letter dated November 11, 1975 from Bertram I. Roland to SNC, "C/O Dr. David Hopwood, Department of Genetics, John Innes Institute", "Re: Pat. Appln. . . . Would you please execute the enclosed assignment which must be notarized by a counsel. When you return it to me, I will have Boyer execute the assignment."; two attachments: 1) "ASSIGNMENT" with SNC's name typed below signature line, but no signature, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 312, 355, and 429]; and 2) four-page "AGREEMENT CONCERNING RIGHTS IN INVENTION" dated June 19, 1975 between SNC and the Board of Trustees of the Leland Stanford Junior University, signed by SNC and Niels Reimers, at top right of first page "SU-178" and handwritten by SNC, "SNC personal files", on p. 3 refers to "the agreement between Stanford and the Board of Regents [of the University of California] dated 1975", the Department of Genetics is not mentioned in this document, which says net royalties go 1/3 SNC for distribution equally to Stanford's Research Development Fund and School of Medicine Dean's Fellowship Fund; 1/3 to the Department of Medicine; and the final 1/3 "shall be expended in the discretion of the Board of Trustees to further the objects and purposes of Stanford"

Signed two-page letter dated November 7, 1975 from John Wicklatz, General Mills Chemicals, Inc. to Niels J. Reimers, handwritten in upper right of p. 1, "xcc Cohen f S74-43", and in SNC's handwriting, "Reimers file"; text begins, "Many thanks for the information included in your letter of October 22. . . . With regard to Professor Cohen's work on "genetic engineering" which you mentioned, we would have to say this is of no interest to us for commercial development. I asked one of our biochemists who is familiar with the work to comment on it and he described it as a "revolutionary development". However, we are not in a position at present to take on a project of this sort which involves such a variety of far-reaching, but still incompletely defined, ramifications. As to courses you might take in licensing the above technology, we have no advice to offer. Our experience in licensing has never taken us into this field."

Small signed note dated October 6, 1975 from Jane Plagge to SNC, "Enclosed you're your records is a copy of the Agreement between the University of California and Stanford."; attached four-page "AGREEMENT CONCERNING ADMINISTRATION OF RIGHTS IN INVENTION" dated August 29, 1975 by and between University of California and Stanford, handwritten by SNC at top right is "Reimers file"; signed on p. 4 for Stanford by Niels Reimers and for the University of California by Constance W. Langton, Assistant Secretary, and David M. Blodgett, Assistant Counsel of the Regents; agreement states "the Invention shall be administered by Stanford" and that net revenues will be split in half between Stanford and UC, text elaborates: "Net revenues" as used in this Agreement shall mean the gross proceeds received by Stanford from the sale, licensing or other disposition of the Invention less (15%) of such gross proceeds to cover Stanford's indirect and overhead expenses, plus deduction of reasonable costs for preparing and filing patent applications and attorneys' fees."

Signed memo dated December 23, 1975 from Niels Reimers to SNC, "Reimers file" handwritten by SNC at top right of page; "Enclosed are copies of the memos about the recombinant DNA process by the Technology Licensing Business School Research Assistants. John Poitras and I will schedule a meeting with you after the first of the year to discuss these reports and where we go from here."; six attachments detailed in rows below

December 23, 1975 memo attachments: 1) Signed two-page memo dated August 13, 1975 from Ken Imatani to Niels Reimers re "File S74-43, Industrial Markets for Recombinant DNA Process; text details [p]rograms of extensive research and development for specific commercial applications", attached to memo is a table, "POTENTIAL COMMERCIAL APPLICATIONS OF RECOMBINANT DNA PROCESS"

December 23, 1975 memo attachments, continued: 2) signed memo dated August 6, 1975 from Ken Imatani to Niels Reimers re "Discussion with Dr Boyer for Future Development Work for Recombinant DNA Process", highlighted is section that begins, "In particular, Dr Boyer hopes to produce the angiotensin-2 hormone from a chemically synthesized replicon of its DNA . . . If this procedure is successful, the next logical extension would focus on the production of insulin."

December 23, 1975 memo attachments, continued: 3) signed memo dated August 5, 1975 from Ken Imatani to Niels Reimers re "signed memo dated August 6, 1975 from Ken Imatani to Niels Reimers re "Trip to Cutter Labs to Discuss Commercial Potential of Recombinant DNA Process"; Cutter Labs say the applications would be inappropriate for their business, however, quotes Dr. Victor Cabasso, Cutter's director of research and chairman of the Biological Section for the Pharmaceutical Manufacturers Association, "If I were a young man again, I would devote my entire life to research and development involving this process.", memo continues, "In addition, Dr Cabasso explained that an example demonstrating commercial use of the product would be required in order for a large pharmaceutical company to make a large capital investment in the process. He recommended seeking government support for a joint industry-university project"

December 23, 1975 memo attachments, continued: 4) one-page of comments dated July 1, 1975, referred to by Josephine Opalka in her July 11, 1975 letter catalogued in Row 384 as: "comments of one reviewer of the invention. The author's identity is held in confidence"; title at top of page: "IN CONFIDENCE Re: PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL DNA CHIMERAS--Cohen-Boyer; comments conclude, "In summary, it is my view that this is a somewhat ill-conceived patent application that disregards (albeit unintentionally) the contributions of other scientists and is very basic in its concepts and applications. While one can argue that the University should attempt to benefit from this scientific achievement, I am concerned that given the fundamental nature of the work and the number of scientists involved, either directly or indirectlly, that this patent will not reflect favorably on the public service ideals of the University."; this page of comments also catalogued in Row 385

December 23, 1975 memo attachments, continued: 5) signed memo dated October 18, 1974 from Bill Carpenter to Niels Reimers, cc Boyer and SNC; "Attached is a brief description of the technique developed by Drs. Boyer and Cohen, the development necessary for commercial application, licensing strategy, and potential dangers to humans. By copy of this memo, I am asking Dr. Boyer and Dr. Cohen to please bring to our attention anything that is incorrect or with which you may not agree."; attached two-page document, "The Plasmid Gene Transplantation Technique"; this memo and two-page attachment also catalogued in Row 410

December 23, 1975 memo attachments, continued: 6) two-page handwritten memo dated September 18, 1974 from BC [Bill Carpenter?], "To: 74-43", "Re: Dr. Herbert Boyer", recaps Boyer's comments on potential applications, also, "The Berg committee is concerned that researchers might try putting animal virus DNA into the plasmids -- Boyer thinks this must be done someday anyway, not sure it's so dangerous -- but it should be approached carefully.", circled in red pen is sentence: "Boyer not planning on signing away his own personal rights to the invention."

Letter dated December 9, 1975 from John K. Poitras, Associate Technology Licensing to Norman G. Brink, Merck Sharp & Dohme, cc SNC and Boyer, "Reimers file" handwritten by SNC at top right of page, note from SNC admin at bottom about trouble with Xerox; letter text: " . . . enclosing copies of the three technical papers describing the Recombinant DNA work." . . . . the Recombinant DNA work was sponsored under grants from the National Institutes of Health, the National Science Foundation, and the American Cancer Society. The latter two agencies have released their rights in the invention to the NIH so that the invention can be administered by Stanford pursuant to its Institutional Patent Agreement with the NIH. . . . We are very interested in moving rapidly to determine the applications of this widely significant technology. . . "; no attachments to letter in file

Signed letter dated October 3, 1975 from Kenneth Imatani, Research Assistant, Office of the Vice President for Business and Finance at Stanford to Harry Robinson, Merck & Company, bcc Boyer and SNC, "Reimers file" handwritten by SNC at top right of page; text, "As agreed in our conversation of yesterday, I am sending you two articles which describe both scientific and potential commercial applications of the recombinant DNA process. Also, attached is a table which identifies particular fields of industrial microbiology in which potential commercial applications may lie. The enclosed material is being provided on a non-confidential basis, and we would very much appreciate your comments on developing a plan for bringing this process forward to public use and benefit. . . ."; attached is signed letter dated September 30, 1975 from John A. Zderic, Syntex (U.S.A.) Inc. to Kenneth Imatani, handwritten at top right "1. NJR, 2. JKP, 3. FILE 74-43 xcc Boyer Cohen" and date stamped at bottom right, "STANFORD UNIVERSITY OCT ? 1975 TECHNOLOGY LICENSING"; re commercial applications, "Unfortunately, this is an area of science where Syntex currently has no work in progress, nor do we foresee that we will be in a position to enter this highly technical field in the near term future. . . ."

Unsigned letter dated October 3, 1975 from SNC to Bertram I. Rowland, cc Niels Reimers; text begins, "Niels has sent along the copy of your letter of October 2, and the accompanying rejection of our claims to the composition. The law may be "quite nebulous" in this area, but if it is primarily based on a "factual consideration" as you indicate, the patent examiner is totally wrong.", continues with details for 17 lines, and concludes, "Having spent so much time with you and with Stanford in attempting to provide the University with appropriate patent coverage, it is damned annoying to have the ignorance of the patent examiner on the subject present a problem of this sort."

Signed letter dated October 3, 1975 from Niels J. Reimers to Herbert W. Boyer and SNC, cc B. I Rowland; text: per attached letter from Bert Rowland, "the claims to the method allowed, but the claims to the composition rejected. My inclination is to go along with Bert's recommendation to let the patent issue with method claims only. We can then refile for the composition claims depending on whether we have a good argument to support the composition claims. I should observe from a "marketing" point of view, the composition claims are normally more valuable than method claims; thus it may be important to develop the "good argument"., any comments appreciated; attached is signed two-page letter dated October 2, 1975 from Bertram I. Rowland to Niels J. Reimers, cc SNC, handwritten at top of p. 1: "xcc Boyer Cohen 10/3" and date stamped at bottom of p. 1: "STANFORD UNIVERSITY OCT 3 1975 TECHNOLOGY LICENSING"; text: rec'd. "Office Action in the subject application, with the claims to the method allowed, but the claims to the composition rejected. . . . This area of the law is quite nebulous and is primarily based on a factual consideration. That is, what is the likelihood of an in vitro plasmid forming a homoduplex with an in vivo plasmid. The second consideration is how would one prove that the plasmid was formed in vivo or in vitro. . . . my recommendation is to allow the claims to the method issue as a patent and refile the application and continue prosecution as to the remaining claims. . . . I look forward to hearing from you."

October 2, 1975 letter catalogued in preceding row with "File Reimers" handwritten by SNC at top of p. 1; three attachments: 1) USPTO action cover sheet re STANLEY N. COHEN ET AL. "MAILED SEP 11 1975 GROUP 170" from A.E. Tanenholtz to Townsend and Townsend; "Responsive to communication filed 6-13-75 This action is made final."; Part I of form is unmarked, Part II lists Claims 1-12 allowed and Claims 13-26 rejected; attached is a two-page opinion dated September 16, 1981 by Alvin E. Tanenholtz, Primary Examiner with handwritten notes by SNC; 2) one-page opinion by Alvin E. Tanenholtz, examiner Art Unit 172 dated September 5, 1975, text: "Claim 23 is rejected as indefinite under 35 USC 112. Merely describing the plasmid in terms of what it can combine with is not a compete and adequate description of the plasmid. Claims 13-26 are rejected as unpatentable over each of Chakrabarty and Holloway under 35 USC 102 . . . This rejection is FINAL."; and 3) Townsend and Townsend letterhead envelope addressed to SNC, "Department of Pharmacology, Stanford University", stamped October 2, 1975

Unsigned letter dated "27 August, 1975" from SNC to Clayton Rich, Dean, School of Medicine, Stanford University, "NR47UH" typed at top of letter and "SNC personal" handwritten by SNC at top right of page; text, "Thank you for your recent kind note concerning the molecular cloning procedure and the assignment of my share of royalties to the Dean's Fellowship Fund and for the support of biomedical research at Stanford. I appreciate your taking the time to write. I am enjoying my sabbatical leave here, and am finding that this sabbatical is accomplishing what sabbaticals are supposed to do - - - I am having the opportunity to experience a change of pace and to look at things with a different perspective."

Signed letter dated August 6, 1975 from Clayton Rich to SNC, handwritten near top right are "SNC" and "c to SNC 8-8-75"; text: congratulates SNC "on your recent invention which undoubtly [sic] will be of great assistance in genetic research" thanks decision to name the Dean's Fellowship Fund to support postdoctoral fellows as a recipient of inventor's share and delighted Dept. of Medicine will receive half of University's share of net revenue

Three documents photocopied half size (5.5" X 8.5") and stapled to one half of a file folder: 1) Unsigned letter dated July 30, 1975 from Niels J. Reimers to Josephine Opalka, Office of the General Counsel, University of California, cc SNC and typewritten next to his name: "Enclosed with your copy of this letter to Miss Opalka is a copy of her letter to me of July 11 for your information only." signed "Niels", below that is handwritten: "Just saw your scientific [sic] American article! We also got the $25K from BD today!, at top right of page "Reimers file" handwritten by SNC; letter text: responding to "query in your letter of July regarding the difficulty our patent counsel has had in obtaining waiver of rights", summarizes situation: seven co-authors on papers with Cohen and Boyer, only one (unnamed) has signed waiver drawn up by Bert Rowland, "At present the patent examiner has not raised the issue of possible inventorship by the co-authors. Anticipating the patent examiner Mr Rowland has asked for affidavits detailing the inventorship situation" from Professors Cohen and Boyer . . ."

Three documents photocopied half size (5.5" X 8.5") and stapled to one half of a file folder, continued: 2) signed two-page letter dated July 11, 1975 from Josephine Opalka to Niels J. Reimers, date stamped "STANFORD UNIVERSITY JUL 14 1975 TECHNOLOGY LICENSING", "xcc Cohen" handwritten at top of p. 1 ; text: "Re: PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL DNA CHIMERAS--Cohen-Boyer I regret the delay in responding to your letter of May 2, 1975, with which you included signature copies of an Agreement covering the referenced invention. The reason for the extended delay is the departure from your original offer, expressed in your letter of August 2, 1974 . . . We interpreted your offer to mean that Stanford would assume all out-of-pocket expenses, deducting them and an appropriate overhead from future royalties prior to making distribution to U.C. Since the agreement you proffered provides for U.C.'s making out-of-pocket payments to Stanford to cover prosecution and related costs, I have had to place the invention in review procedure. This will result in our having to make some revisions in the Agreement. . . . I enclose for your information the comments of one reviewer of the invention. The author's identify is held in confidence . . . ", also has learned certain individuals at Stanford and U.C. have refused to sign waiver of rights. Insofar as this may influence our obtaining or retaining a valid patent, will you please let us have counsel's opinion as to the legal effect of these refusals."

Three documents photocopied half size (5.5" X 8.5") and stapled to one half of a file folder, continued: 3) one-page report catalogued in Row 373

Unsigned letter dated July 30, 1975 from Niels J Reimers to Josephine Opalka; same letter is catalogued in Row 383, only this one is full-size and has handwritten "c to SNC 8-1-75"

Signed letter dated July 23, 1975 from Niels J. Reimers to SNC at "Department of Genetics, John Innes Institute", in upper right of page, "Reimers file" handwritten by SNC; text, received your signed copies of the Agreement and enclosed your copy, "I have advised our accounting people to defer any payments to you until after January 1, 1976 per your request."

Full-size copy of July 11, 1975 two-page letter catalogued in Row 384, on this copy handwritten at top right of p. 1, "sent copy 7-29-75 c to SNC in Engl. 7-31-75, letter is stapled to copy of one page of comments dated July 1, 1975 catalogued in Row 373

Signed memo dated June 20, 1975 from Cassius L. Kirk, Jr. Staff Counsel, Stanford to Niels J. Reimers, "SUBJECT: Royalty Sharing Agreement with Dr. Cohen -- Biologically Functional Molecular DNA Chimeras"; text: attached are two execution copies and an extra copy of a revision of the proposed agreement with Dr. Cohen", endeavored to incorporate substance of changes you discussed re wording of subparagraph 3(a) and "[p]er your suggestion, paragraph 7 has been deleted."; attachment catalogued in Row 390

Attachment to June 20, 1975 memo catalogued in Row 389: signed memo dated June 19, 1975 from Cassius L. Kirk, Jr. to Niels J. Reimers, "SUBJECT: Royalty Sharing Agreement with Dr. Cohen"; text: enclosed draft of Royalty Sharing Agreement, "I have left blank the percentage of net royalty to be paid to a charitable organization designated by Dr. Cohen. I assume that Dr. Boyer will want to enter into a similar agreement and was not sure as to the percentage breakdown between Drs. Cohen and Boyer.", as noted in Kirk's April 29, 1975 memo to Reimers [catalogued in Row 395], " . . if Dr. Cohen retains the right to designate the disposition of the royalties he would otherwise have received, the IRS might consider the royalty income to be income of Dr. Cohen. . . . Should the invention turn out to be lucrative, it is conceivable that the amount of royalties contributed by Dr. Cohen would exceed 50 percent of his adjusted gross income. In such a situation, Dr. Cohen would have to pay income tax on a portion of the royalties contributed to charity. However, if Dr. Cohen and his attorney are not concerned about this possible exposure, I do not think the University need be."

Unsigned letter dated June 18, 1975 from SNC to Bertrand I. Roland [sic], handwritten at top right (not by SNC) is "Reimers"; text: thanks for sending copy of amendment filed for patent application, "In general, I think the arguments you have made are reasonable and appropriate. However, I think you could have been a bit stronger about the "improbability" of chimeras formed by natural means between organisms that ordinarily do not exchange genetic information. Based on all that is known in molecular biology, the likelihood of such an event occurring may be even less than "infinitely small". By definition, organisms that do not exchange genetic information cannot form molecular hybrids."

Unsigned letter dated June 9, 1975 from SNC to Niels Reimers; text, "As we discussed by telephone, I would like you to use your standard contract form in the assignment of the molecular cloning patent to Stanford by me, except as follows:" then 11 lines detailing distribution, also suggests idea for usage of funds going to Dept. of Medicine, "I plan to leave for England around June 23rd. We really need to complete arrangement prior to that time. . . ."

Three letters stapled together: 1) unsigned letter dated June 5, 1975 from SNC to Bert Roland [sic]; text, "I plan to leave for England on my sabbatical on June 20. I hope the information I provided for you in my recent letters will be suitable, but if not we should plan to talk before I leave."; 2) unsigned two-page letter dated May 20, 1975 from SNC to Bertrand I. Roland [sic], "Reimers file" handwritten by SNC at top right of p. 1; same text as copy of letter catalogued in Row 156, except that second-to-last paragraph typed twice in this letter and second instance crossed out; 3) another unsigned two-page letter dated May 20, 1975 from SNC to Bertrand I. Roland [sic]; text begins, "I've reviewed the information sent to you by the Patent Office Examiner. I'm not sure that I understand all of the points the examiner has made in connection with his rejection of our claims 10-26 of the patent, but want to respond on the basis of what I think he is saying.", rest of letter contains response

Signed letter dated May 12, 1976 from Bertram I. Rowland to SNC, paper has two large blue ink spots; text: re patent application, "Please find enclosed materials per your request."; no attachments to letter in file

Signed memo dated May 2, 1975 from Niels Reimers to SNC, CC C. L. Kirk, Jr.; text: two topics, attached memo from Cash Kirk and two alternate forms of waiver re royalty income, also three execution copies plus extra copy of Assignment of Application for Patent attached; three attachments: 1) signed memo dated April 29, 1975 from Cassius L. Kirk, Jr. to Niels Reimers, "SUBJECT: Release of Rights to Receive Royalty Income (Process and Composition for Biologically Functional Molecular DNA Chimeras", date stamped, "STANFORD UNIVERSITY APR 30 1975 TECHNOLOGY LICENSING"; text: "Attached are two forms of Waiver by Dr. Cohen of his right to receive royalty income from the above referenced invention. These forms include suggestions made by Gordy Weber in a telephone conversation this morning. . . You will note that the longer form contains a statement as to the understanding by Dr. Cohen as to the disposition to be made by the University of the royalty income which would otherwise have been received by him. Gordy advises that there is some risk that by including this paragraph the IRS might consider the royalty income to be income of Dr. Cohen. . . . Please have Dr. Cohen sign the original of either of the enclosed forms (but not both)."; this memo quoted in June 19, 1975 memo catalogued in Row 390; 2) unsigned longer waiver, this waiver also catalogued in Row 405; 3) unsigned shorter waiver

Two letters stapled together: 1) signed letter dated April 28, 1975 from Niels J. Reimers to Donald W. Carlin, Kraftco Corporation, cc H.W. Boyer and SNC, "File Reimers file" handwritten by SNC at top right of page; text: "You will recall my communication with you in November about the genetic engineering work from Stanford. Enclosed are copies of two articles from the December 1974 and April 1975 issues of Bioscience which will be useful for background regarding the genetic engineering work. Additionally, several practical applications are indicated. . . "; 2) signed letter dated April 28, 1975 from Niels J. Reimers to Bernard A. Shoor, Becton, Dickinson Electronic Laboratory, cc H.W. Boyer and SNC; text: same articles enclosed as in previous letter, mentions they contain "potential practical applications"

signed letter dated April 15, 1975 from Niels J. Reimers to Bernard A. Shoor, Becton, Dickinson Electronic Laboratory, cc SNC, "Reimers file" handwritten by SNC at top right of page; text: "You will recall our recent telephone conversation about the "genetic engineering" discovery from Stanford. . . . ", enclosed are three PNAS reprints "which describe the work. I also refer you to recent articles in Science (14 March 1975), Chemical and Engineering News (10 March 1975), and Chemical and Engineering News 3 February 1975) [sic]. . . . I will look forward to hearing from you about Becton, Dickinson's interest in this work."; no attachments to letter in file

Signed letter dated "18th February, 1975.", "Dictated by and signed on behalf of Dr. K. Murray." of University of Edinburgh to N.J. Reimers, "xcc Cohen Berg Massy" handwritten at top right of page, date stamped "STANFORD UNIVERSITY FEB 25 1975 TECHNOLOGY LICENSING"; text, "Thank you very much indeed for your letter of 3rd February and various enclosures clarifying the situation described by Dr. Morrow in his letter of January 23rd to me. It was very considerate of you to go to all this trouble."; paper has been dented at top by a paper clip, but no attachments in file

Signed memo dated February 10, 1975 from Niels Reimers to William Massy, cc H.W. Boyer, SNC, "File Reimers file" handwritten by SNC at top right of page; entire text: "Last Thursday I met with Paul Berg, David Hogness, Stan Cohen, Charles Yanofsky, and Ronald Davis in Professor Berg's office. The subject was the perception of Stanford's motives by the scientific community in filing a patent application for the "gene transplant" work, while at the same time advising the scientific community to "go slow" with respect to related research. A concern also was the scientific reputation of Dr. Cohen and Dr. Boyer of the University of California, a co-inventor with Dr. Cohen. Our patent attorney had innocently touched off the above concerns by sending out a letter to a number of Dr. Cohen's and Dr. Boyer's colleagues asking them to sign affidavits that they were not co-inventors. The letter gave the mistaken impression that Drs. Cohen and Boyer were personally filing the patent application and would receive material benefit. Hurry-up phone calls, letters and telegrams were sent out but not before the situation was made known to quite a number of people. We seem to have been able to defuse the situation with respect to Drs. Cohen and Boyer. Neither are claiming any financial return from any possible revenue which might be received from the invention. There continues some concern with respect to the perception of Stanford's and U.C.'s role in this matter and several courses of action were discussed. It was considered appropriate that a meeting be scheduled with you to discuss these possible solutions which include: 1) proceeding as before 2) turning the invention over to Research Corporation and 3) abandoning the patent. I'll be in touch with you later to schedule such a meeting."

Signed letter dated January 28, 1975 from Bertram I. Rowland to SNC, cc: Herbert W. Boyer, "Re: Pat. appln. for PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS - S. Cohen and H. Boyer"; text: "Enclosed is a copy of the letter I wrote to the co-authors of the above reference patent application clarifying the situation to them. A xerox copy of your letter dated January 22nd is also enclosed."; no attachments to letter in file

Signed letter dated January 23, 1975 from John F. Morrow, Carnegie Institution of Washington to SNC and Boyer, cc: Bertram I. Rowland, "Reimers file" handwritten by SNC at top right of page; letter catalogued in Row 154

Unsigned letter dated January 22, 1975 from SNC to Bertram I. Rowland; letter catalogued in Rows 153, 403, and 404

Signed letter dated January 22, 1975 from SNC to Bertram I. Rowland, stamped "RECEIVED JAN 24 1975 TOWNSEND AND TOWNSEND PENINSULA OFFICE"; letter catalogued in Rows 153, 402, and 404

Unsigned letter dated January 22, 1975 from SNC to Bertram I. Rowland, handwritten at bottom (not by SNC): "copies sent to: John F. Morrow, Charles Yanofsky, Herb Boyer, Donald Helinski"; letter catalogued in Rows 153, 402, and 403

Unsigned longer version of SNC's Waiver of right to receive royalty income, "Reimers file" handwritten by SNC at top right of page; this unsigned waiver also catalogued in Row 395

Two documents stapled together: 1) the extra copy of Assignment of Application for Patent referred to in May 2, 1975 memo catalogued in Row 395; three pages; pp. 1-2 "ASSIGNMENT OF APPLICATION FOR PATENT" with unsigned signature lines on p. 2 for Boyer, SNC, and Robert R. Augsburger, Vice President for Business and Finance, Stanford, p. 3 contains text for notarizing of all three signatures; 2) one-page unsigned Royalty Sharing Agreement described in the memo dated June 19, 1975 from Cassius L. Kirk, Jr. to Niels J. Reimers

95 5
Cohen/Boyer patent information, 1976

Signed five-page memo dated November 15, 1976 from Niels J. Reimers to SNC, Daniel Federman, I. Robert Lehman, Clayton Rich, Robert Rosenzweig, "Reimers file" handwritten by SNC in top right corner of p. 1, Subject: Genetic Engineering License; text begins, "This memo is intended as background for our meeting" November 24 at 1:30 p.m., "We anticipate receiving soon from NIH their release to license. Licensing will then be up to Stanford", sections of memo are: I. Property, II. Licensing Objectives, III. Licensing Negatives, IV. Industry Interaction, V. The Licensing Plan, and VI. Summary

Signed memo dated November 9, 1976 from Niels Reimers to Daniel Federman, cc SNC, "Reimers file" handwritten by SNC at top right; text begins, "Enclosed are copies of the memos that we spoke about concerning Stan's participating in licensing decisions on Recombinant DNA. Also enclosed is a copy of the CETUS August 21, 1976 "Letter to the Shareholders.", SNC has reaffirmed "his association with CETUS is as a scientific consultant on a fee-for-service basis only . . . . Stan would like to participate in the meeting which is scheduled" for November 24 at 1:30 p.m.; no attachments

Memo dated August 24, 1976 from John H. Rautischek to Betsy Clark, cc Niels Riemers [sic], Norm Latker, Chuck Herz, re "Invention disclosure NSF-75-17-GB-30581 Stanford University", in upper right "REIMERS file" handwritten by SNC; thanks for June 24th Nature article about Cohen-Boyer invention, "It is of interest that the NSF support from Herman Lewis' program was not mentioned in the article but perhaps we don't need the publicity."

News release dated July 19, 1976 from Stanford University Medical Center News Bureau, Contacts: Spyros Andreopoulos at Stanford, Michela Reichman at UCSF, "File - PATENT" handwritten by SNC in upper right, "SCIENCE WRITERS: The following story is distributed jointly with the University of California, San Francisco"; first sentence: "Stanford University and the University of California have filed an application to patent key elements of a new genetic engineering technique developed by scientists at both institutions."

Signed memo dated July 19, 1976 from SNC to Robert M. Rosenzweig, cc R. Augsburger, W. Massy, N. Riemers, C. Rich, SUBJECT: DNA Cloning Patent; text begins, "I wish I could agree with you that it is possible for me to completely detach myself from the University's decisions about the DNA cloning patent. . . . At the Miles Symposium where the patent issue was first raised publicly, I was able to effectively disarm critics in what could have been a very difficult situation. If instead of answering questions in an informed, honest and straightforward manner, I had responded by saying that I have "no knowledge or voice in the University's decision" as you have suggested, the public perception would surely have been that either I or the University, or both, have something to hide. . . . From my discussions with Neils Riemers [sic], it seems clear that the University administration will need to obtain advice on such matters [as patent policy] from faculty scientists, since scientific as well as purely business considerations are involved. . . . As I noted in my earlier memo to Neils Riemers [sic], I believe that any scientific advice I might provide to the Cetus Corporation can be disassociated entirely from input I provide to the University in connection with its licensing of this patent. . . ."

Signed letter dated July 9, 1976 from Robert M. Rosenzweig to Donald S. Fredrickson, bcc Richard W. Lyman, Bill Massy, Jim Siena, Clayton Rich, Paul Berg, David Hogness, Josh Lederberg, SNC, "Reimers file" handwritten by SNC at top right; "Thank you for your letter of July 6. I was pleased to know, as indeed Dr. Perpich had told me, that you have begun a careful review of patent policies with respect to recombinant DNA. . . . we have taken some pains to consult fairly widely about the wisdom and propriety of our proposed course of action and . . . have held off making irrevocable decisions until consultative processes had a chance to work. . . .[re NIH deliberations] Let me repeat my earlier offer to participate in those deliberations, or to arrange for participation by others at Stanford. Let me also urge that you act with both deliberation and dispatch. . . ."; attached is signed letter dated July 6, 1976 from Donald S. Fredrickson to Robert M. Rosenzweig, date stamped "RECEIVED JUL 8 1976 Vice President for Public Affairs"; text: responding to your letter of June 18, " . . . Dr. Joseph Perpich has told me of his conversation with you concerning the patent issues you raised in your letter and the accompanying memorandum. . . . I have undertaken a careful review of our patent policies with respect to recombinant DNA research. . . . Norman Latker, the patent counsel" for DHEW "may already have told you--in proceeding to obtain patents, Stanford has acted consistently within the terms of the institutional agreement Stanford has with the Department. I shall keep you informed of my policy review."

Signed memo dated July 7, 1976 from Robert M. Rosenzweig to SNC, cc R. Augsburger, W. Massy, N. Reimers, C. Rich, "Reimers file" handwritten by SNC in upper right of page; text begins "I have thought a good deal about your memorandum of June 14 to Niels Reimers. The questions you raise are not for me to decide--Clayton Rich, Bill Massy an Bob Augsburger have responsibilities more direct than mine. I cannot help but wonder, though, whether what you propose -- full knowledge of all aspects of licensing arrangement -- is the best way to achieve your aim -- avoiding damage to your professional reputation by virtue of association with unpopular University decisions. . . . If you can say to critics, "I had no knowledge of or voice in that decision" then I think you have effectively disarmed their criticism, at least as it applies to you. . . . I think you have a legitimate and important role in decision-making with respect to exploitation of the patent as a scientist and a member of the faculty. . . ."

Signed letter dated July 2, 1976 from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY JUL 6 1976 TECHNOLOGY LICENSING", handwritten at top right 1. JKP 2. fS74-43 xcc Cohen Boyer" and in SNC's handwriting, "File - Reimers", "Applicant: STANLEY N. COHEN, et al., Serial No.: 687,430, Filing Date: 05/17/76, For: PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS, Our File No.: 5490-2-1; text begins, "The application above has been filed in the United States Patent and Trademark Office. . . ."

Signed memo dated June 30, 1976 from Robert M. Rosenzweig to R. Augsburger, P. Berg, S. Cohen, R.W. Lyman, W.F. Massy, N. Reimers, C. Rich, J. Siena, "File Reimer" handwritten by SNC at top right, "SUBJECT: Telephone Conversation with Joseph Perpich, Associate Director for Program Planning, NIH"; text begins: "On June 29 I called Donald Fredrickson, following my letter to him of June 18. Fredrickson was not available, but Dr. Perpich returned my call. . . . He said that NIH had received "several" letters inquiring about reports of patent activity in the Recombinant DNA area by Stanford and the University of Alabama, and so there was a need for them to consider the matter and decide what, if any, position NIH should take. . . . I made three points throughout", "1. We did not want the issue to be handled in such a way as to enable people to believe that we were acting in a secretive, sly, or underhanded way. . . . 2. We had a time problem with respect to one potential licensee . . . . 3. We are eager to have NIH's views on the soundest course to pursue, understanding, of course, that we might disagree with them when we know what they are. . . . "

Signed memo dated June 18, 1976 from Niels Reimers to Robert Rosenzweig, cc Stan Cohen, "Reimers file" handwritten by SNC at top right; text refers to attached June 14 memo from SNC re "possible appearance of a conflict of interest because of his role as a consultant with Cetus vs. his role as a confidant and advisor i the process of licensing to commercial entities . . . the association of Dr. Cohen and Dr. Lederberg with Cetus, the investment of other Stanford-related people in Cetus, as well as the investment of the University itself in Cetus, have been a matter of specific concern to representatives of a company with which we have been in contact . . . There is, of course, no issue if non-exclusive licensing only is followed. . . . I should also mention that we are not involving Herb Boyer in the business side of Recombinant DNA for even more obvious reasons. . . . would you please be kind enough to give Stan and me the benefit of your counsel?"; no attachments

Signed two-page letter dated June 18, 1976 from Robert M. Rosenzweig to Donald S. Fredrickson, cc R.W. Lyman, W.F. Massy, C. Rich, P. Berg, S. Cohen, "Reimers file" handwritten by SNC at top right of p. 1; text begins, "From Paul Berg and others I know that you are aware of the discussions taking place at Stanford now over the wisdom of proceeding (on behalf of Stanford and the University of California) with an application for patent protection for discoveries in the area of Recombinant DNA. As you know, we began to move in this direction with the knowledge and consent of NIH and NSF . . . The purpose of this letter is to solicit your views. . . .", refers to enclosed memo "in which I have attempted to summarize some of the major questions and address them in a way that makes sense to me, at least. . . . One point on which there is substantial unanimity among the officers of the University is that, if this line of work is to be developed in a way that provides income to the holder of a patent, there is no institution or group that has a stronger claim to that income than Stanford and the University of California . . ."; attached signed four-page memo dated June 4, 1976 from Robert M. Rosenzweig to "Those Interested in Recombinant DNA", "SUBJECT: Thoughts on the Patent Question", memo sections: I The Effect of Patents on the Conduct of Science, II Commercial Development and Basic Research, III The University's Financial Condition, IV Conflict of Interest and Public Policy, then: " . . . It will be clear to readers by now that my strong preference is to press for patent protection and a responsible licensing program. . . . I solicit the views of all who read this."

Photocopy of C&EN, June 7, 1976, p. 7, "File - Reimers" handwritten by SNC at top right, page 7 contains article, "Industry wary about genetic guidelines," no byline, text: NIH recombinant DNA guidelines "have been tailored to the conditions of research in universities and government laboratories and in some aspects may not be reasonable as guidelines for industry" according to some industry reps, "A modified version of the guidelines more useful to industry seems a good idea, both Dr. Fredrickson and industry representatives agree."

June 4, 1976 memo described above in Row 348, with "Please circulate around lab." and "Reimers" handwritten, not by SNC, at top of p. 1; eight sets of initials at top right of p. 1, including "SNC"

Five-page "SUPPLEMENTAL RESPONSE" to A. Tanenholtz, "Patent file" handwritten by SNC at top right of p. 1, signed on p. 5 by Bertram I. Rowland on October 4, 1977, handwritten "cc: Stanley Cohen, Herbert W. Boyer, Niels J. Reimers"; text begins, "Supplemental to the June 24 response to the Office Action of April 5, 1977, applicants, by their attorney, wish to submit the following remarks."

Four-page "RESPONSE UNDER RULE 116" to A. Tanenholtz, "Patent file" handwritten by SNC at top right of p. 1, signed on p. 4 by Bertram I. Rowland on October 25, 1977, typewritten cc: Stanley Cohen, Niels J. Reimers"; text begins, "In response to the FINAL REJECTION of October 3, 1977, the Examiner is earnestly requested to withdraw the rejections in view of the following remarks. Unfortunately, a supplemental reponse [sic] did not arrive at the Examiner's desk prior to his preparation of the FINAL REJECTION."

Four-page "SUPPLEMENTAL RESPONSE" to A. Tanenholtz with unsigned signature line on p. 4 for Bertram I. Rowland; text begins, "Supplemental to the June 24 response to the Office Action of April 5, 1977, applicants, by their attorney, wish to submit the following remarks. The courteous interview granted applicants' attorney is gratefully acknowledged."

Seven-page "AMENDMENT" to A. Tanenholtz, "Patent file" handwritten by SNC at top right of p. 1, signed on p. 7 by Bertram I. Rowland on June 24, 1977; text amends Claims 40 and 44, cancels Claim 45

Signed letter dated May 12, 1976 from Bertram I. Rowland to SNC, right margin has note handwritten by SNC, "db - please send enclosed to Bert Rowland at above address. Keep copy for our files" and written next to it in a different hand, "5-13-76", SNC notes at bottom of page, "P. 14 row" and "16 - J. Bact."; three attachments: 1) "ASSIGNMENT" signed but not dated by SNC, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 312, 366, and 429]; 2) "DECLARATION AND POWER OF ATTORNEY" signed by SNC on May 12, 1976 appointing 13 listed "attorney(s) and/or agent(s) to prosecute this application and transact all business in the Patent and Trademark Office connected therewith" (including Bertram I. Rowland) [newer signed version of slightly different form (21 lawyers listed) catalogued in Row 312 and unsigned 21-lawyer version of form catalogued in Row 430]; 3) undated 40-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS"

Unsigned two-page letter dated April 28, 1976 from SNC to Bertram I. Roland [sic], at end of letter "c to P. Farley (CETUS) 5-5-76" handwritten, not by SNC or Karen Carpenter, 'COHEN-BOYER PATENT" handwritten at top of p. 1 by Karen Carpenter; text begins: "Enclosed is the information you requested. My lack of time right now limits completeness. I. General categories of composition. . . ." with brief scientific/technical answers numbered 1-2, 4-11

"Dictated but not read" letter dated April 22, 1976 from Bertram I. Rowland to SNC, cc Herbert Boyer, Niels Reimers, "Reimers - file" handwritten by SNC at top right; text contains five paragraphs of requests for scientific/technical information re patent application

Signed letter dated March 25, 1976 from John A. King, American Cyanamid Company to Niels J. Reimers, date stamped "STANFORD UNIVERSITY MAR 29 1976 TECHNOLOGY LICENSING", in top right, "xcc Cohen Poitras f S74-43" handwritten and handwritten by SNC, "file Reimers"; text: ". . . . Enclosed is a copy of King's notes on "Gene Transfer Process" from "my notes on the non-confidential conversation I had with NRDC people last Fall about the position of ICI on the gene transfer process work done at Edinburgh University. . . . "; attached Cyanamid "Memorandum II National Research Development Corp. JAK Visit of 9/3/75 Page -14- "U. Gene Transfer Process", "They told me that there had been filed, about a year ago, patent applications on the work of the two Murrays, at Edinburgh University, which had been sponsored by the Medical Research Council and which was tied up by and tied in with ICI on a gene transfer process using a phage as the carrier. . . ." text continues for total of 18 lines

Unsigned two-page letter dated March 1, 1976 from SNC to Bert Roland [sic], cc Niels Reimers; "In reference to your plans to resubmit a patent application to provide better coverage for Stanford, I have the following comments: 1) You indicated a need to define organisms that are "ordinarily unable to exchange genetic information" I believe this can be covered by the situation where DNA from one organism is not known to be able to propagate itself in the second organism. . . . 2) In organisms that can exchange genetic information biologically without the use of this methodology, I cannot think of any way to provide tight coverage against surreptitious attempts to get around Stanford's patent. . . . I am sorry that I can't be of more help regarding item 2. However, I think you should be able to get very tight coverage in the area of item 1, which I believe is where most of the financial rewards to Stanford will eventually be realized. . . ."; letter mentions "I have enclosed a copy of my Federation Proceedings review on Translocations" but there is no attachment to letter in file

Unsigned letter dated February 3, 1976 from SNC to Niels Reimers; re "Agreement concerning rights in DNA cloning procedure . . . It has come to my attention that a couple of other things need clarification in the above agreement: 1. The draft agreement dated June 19, 1975 has no termination date. . . . 2. I would like the agreement to contain a clause assigning all of my rights and privileges to my heirs or an assignee. . ."

Unsigned letter dated January 28, 1976 from SNC to Niels Reimers; re "Agreement concerning processing composition for biologically functional molecular DNA chimeras, described in U.S. Patent Application 520,691", "As a follow-up to my memo of January 6, 1976 on this subject, I would like to propose the following modifications in the above agreement:" then three changes described in 17 lines of text, then, "My request for these changes is motivated by personal and tax considerations. . . ."

Signed letter dated January 26, 1976 from Niels J. Reimers to Bertram I. Rowland, cc SNC and Boyer, "Reimers file" handwritten by SNC at top right of page; "Subject: Patent Application for "Process & Composition for Biologically Functional Molecular DNA Chimeras," your file 5490-2, Stanford file S74-43"; text: "Your recommendation regarding the prosecution o f the above patent application, as contained in your letter of January 21, 1976, and based upon discussions with Dr. Cohen, is to allow the application to issue and then refile. Please consider this letter as your authorization to refile--of course prior to the issuance of the above application."

Signed three-page letter dated January 21, 1976 from Bertram I. Rowland to Niels J. Reimers, cc SNC, "Reimers file" handwritten by SNC at top right of page; text begins, "After being somewhat elated with my progress in the subject application, after discussions with Stanley, my gratification diminished significantly. What I apparently thought was great progress in obtaining substantial coverage for the subject invention was being undermined by new scientific advances. Accompanying this letter are the new claims which the Examiner indicated he would be willing to allow." [no attachments to letter in file], next 33 lines discuss claims, including comment re Claim 23, "Stanley informs me of two problems with this claim. . . .", final paragraph begins: "It is possible to allow the subject application to issue, while refiling a modified version and expanding the discussion concerned with the differences between DNA segments which could not be joined in vivo and those which theoretically could be joined in vivo. . . ."

Unsigned letter dated January 6, 1976 from SNC to Niels Reimers, "File - Reimers" handwritten by SNC at top right of page; re "Licensing procedure for DNA cloning procedure"; text begins, "As we discussed today by telephone, I would like to propose some modifications in the licensing agreement that I signed and returned to you recently. These changes concern the sections on distribution of funds from the departmental and inventor's share of royalties.", comments that since "I have never received an executed copy of this agreement signed by you . . . I understand that modifications can still be readily carried out. . . ."; at bottom of page is typewritten, "Handwritten note attached: Niels, This seemed like one way to handle things without sticking you with the responsibility for re-opening the matter. Please let me know if you feel it presents any problem. Stan"

Newspaper clipping glued to 8-1/2" X 11" paper, with "Patent File" handwritten (not by SNC) at top right of page; "By Stanford, UC Patent Filed for Genetic 'Process'", no byline, pp. 1 and ?, Medical Center MEMO, Vol. 18, No. 6, 1976.; text: ". . . If awarded, the patent would cover commercial use of the process, said Niels Reimers, manager of Stanford's technology licensing program. It would not affect its use for academic or industrial research. . . . However, William F. Massy, acting vice-president and provost, stressed that Stanford has made no decision to exploit the technique commercially. "The matter is still under discussion with federal officials and being debated internally," he said. . . ."

95 6
Cohen/Boyer patent information, 1977

Signed letter dated December 5, 1978 from Bertram I. Rowland to SNC and Boyer, cc to Reimers, "BRANSON" handwritten by SNC in margin and above in, in another hand, "Debbie Branson"; text: please sign and return enclosed "Continuation-in-Part Patent Application"; stapled behind this letter is another signed letter, dated December 6, 1979 from SNC to Rowland, text: enclosed is Continuation-in-Part Patent Application "duly signed and notarized"

Undated 40-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", printed double-sided; attached behind it with a butterfly clamp is one sheet of paper with two forms printed on it: 1) on one side is "DECLARATION AND POWER OF ATTORNEY" signed by SNC on December 1, 1978 appointing 21 listed "attorney(s) and/or agent(s) who are partners and associates in the firm of Townsend and Townsend to prosecute this application and transact all business in the Patent and Trademark Office connected therewith" (including Bertram I. Rowland) [unsigned version of same form catalogued in Row 430 and older signed version of slightly different form (13 lawyers listed) catalogued in Row 355] ; 2) on the other side is "ASSIGNMENT" signed by SNC on December 1, 1978 and notarized by Debi Prunier, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 355, 366, and 429]

Signed letter dated December 1, 1978 from SNC to Bertram I. Rowland, cc to Niels J. Reimers, text: "Enclosed are two signed and notarized copies of the continuation-in-part patent application for the recombinant DNA process. You will need to get Herb Boyer's signature separately."; stapled behind it is signed letter from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY NOV 9 1978 TECHNOLOGY LICENSING" with notes handwritten by SNC at top ("Rita Philip 76221") and bottom ("Debby Branson 77950"); text: "Enclosed are two copies of the captioned continuation-in-part application for review by you and the inventors. . . . . On November 7, 1978, we filed continuation application . . . of Application Serial No. 687,430 which was originally filed on May 17, 1976 . . . . The application was directed to the claims to compositions rejected by the Examiner."

Photocopy of nine-page "DECLARATION UNDER RULE 132" signed by SNC on October 28, 1982, "Final 10/28/82" handwritten by SNC at top right of first page

Unsigned 26-page AMENDMENT "In response to the Office Action of August 2, 1982" with signature line for Bertram I. Rowland; "To be revised" handwritten by SNC at top right of first page, on p. 10 is a post-it with illegible handwriting by SNC, on p. 17 is a post-it with "Make too b___ align of Hogness not prior" handwritten by SNC

Signed letter dated October 17, 1978 from Niels J. Reimers to Nature Magazine, cc to SNC, Norman Latker - HEW, Dr. Donald Fredrickson - NIH, at top right "Patent file" handwritten by SNC in pen and crossed out in pencil; text: comments re "article by John Douglas, "U. S. Geneticists Look to Europe for Research Facilities," in the September 21, 1978 issue", 1) lists sources of support for the original research: American Cancer Society, National Science Foundation, National Institutes of Health, University of California, and Stanford; and 2) "The existence of a patent per se does not inhibit research in the U.S. or elsewhere. The only basis on which this particular patent (if granted) might become a factor in the choosing of a site of research is that, as noted earlier in the article, industrial licensees of the patent will be required to follow the NIH safety guidelines for genetic engineering."

Memo dated September 27, 1978 from SNC to Niels Reimers; "I have reviewed your draft of a license agreement for companies . . . . I have no substantive modifications to suggest."; three attachments stapled to memo: 1) Signed memo dated September 19, 1978 from Robert M. Rosenzweig to Niels Reimers, cc S. Cohen, M. Hudnall, G. Lieberman, W. Massy, B. Rowland, Subject: Licenses for Cohen/Boyer work, handwritten by SNC in upper right is "Stanford Patent file"; text: he had reservations about licensing because of concern "that we not worsen the political climate in which the regulation of recombinant DNA research would be handled. My concerns in that area have greatly diminished in recent months as some balance has been restored to the public policy debate. . . . My present view, therefore, is that we should proceed to put into effect the best licensing program we can manage."; 2) Signed memo dated September 14, 1978 from Niels Reimers to SNC, Mike Hudnall, and Bert Rowland, cc to R. Rosenzweig, G. Lieberman, W. Massy, Subject: License for Cohen/Boyer Work; text: "Enclosed is your copy of a very rough first draft of a license for the Cohen/Boyer work. Each draft is numbered, and I would appreciate your not making any further distribution. Please be aware the earned royalty rate that I used is not at all firm. I particularly would like Bert's comments on basing royalties on products which may not be made by our licensee, Mike's comments on "safety guidelines," and Stan's on "End Products." . . . . After another drafting, I will probably go to one or more potential licensees on an informal basis to try it on them. . . . this scenario is of course contingent upon a formal decision by Stanford to license at all"; 3) nine-page "D R A F T AGREEMENT" for licensing Cohen/Boyer work, at top right of p. 1 is handwritten "Copy #3", on p. 3 a handwritten correction by SNC changing date of NIH Guidelines from December 1976 to July 23, 1976, and on same page after typewritten "licensee shall pay to Stanford the sum of" is a large gap in which "fifteen" handwritten by SNC, then typing resumes "thousand dollars . . ."

Signed letter dated June 1, 1978 from Kenneth R. Allen, Townsend and Townsend to SNC and Boyer, cc to Neils[sic] Reimers, at top right handwritten (not by SNC) "opened" and date stamped "JUN 6 1978" and in left margin near bottom handwritten (not by SNC) "Returned 6/8/78"; text, enclosed for signature and return "a further declaration which must be filed in this patent application in order to place it in a condition to be issued to Stanford"; no attachments

Signed letter dated May 2, 1978 from Bertram I. Rowland to SNC, cc to Neils [sic] Reimers, text: enclosed declaration "must be filed in this patent application in order to place it in a condition to be issued to Stanford", please sign and return; handwritten by SNC at bottom, "Please Xerox attached - Return original --> Bert Rowland"; attached is photocopy of two-page RESPONSE UNDER SECTION 152 OF THE ATOMIC ENERGY ACT OF 1954, signed by SNC on May 4, 1978, stating there was no "contract, subcontract or arrangement entered into with or for the benefit of the Nuclear Regulatory Commission" and that Stanford, UC, HEW, the ACS and NSF "all agreed that the invention was to be administered by Stanford"

43-page report, "THE PATENTING OF RECOMBINANT DNA RESEARCH INVENTIONS DEVELOPED UNDER DHEW SUPPORT: An Analysis by the Director, National Institutes of Health November 1977"; first page is photocopy of a letter dated March 2, 1978 from Donald S. Fredrickson to Robert M. Rosenzweig, text includes, " . . . it is my recommendation that at least for the present, recombinant DNA research inventions developed under DHEW-NIH support should continue to be administered within current DHEW patent agreements with the universities."; paper clipped to front of report is small photocopied note dated March 10,1978 from Donald S. Fredrickson, not addressed to anyone,, at top right of note date stamped "MAR 29 1978" and "Patent file" handwritten by SNC, text of note begins, "Enclosed is a copy of an analysis and decision on the patenting of recombinant DNA research inventions developed with DHEW support."

Signed letter dated March 17, 1978 from Niels J. Reimers to Bertram I. Rowland, cc to SNC and Herbert Boyer, "Patent file" handwritten by SNC at top right; Reimers states that the Atomic Energy Commission had no connection to the subject invention; SNC received support from the NIH and Stanford, Boyer was supported by the NSF, ACS and UC, concludes, "Bert, if you happen to find out what applications there are of this technology in "special nuclear material or atomic energy," I would be pleased to find out. I have not read in the literature nor heard from industry that such applications were contemplated or possible."; two attachments: 1) Signed letter dated March 14, 1978 from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY MAR 15 1978 TECHNOLOGY LICENSING" asking for information on "sources of support for the subject invention", Rowland will then prepare statements for SNC and Boyer to sign; 2) USPTO communication "FILED May 17, 1976" from Benjamin R. Padgett, Special Laws Administration Group, sent to Townsend & Townsend, date stamped in upper left corner "PAT. & T.M. OFFICE MAILED FEB 1 1978 SECURITY GROUP LICENSING & REVIEW", also stamped at top of page, "RECEIVED 1978 FEB 16 PM 3:05 TOWNSEND & TOWNSEND", text states, "The subject matter of this application appears to be "useful in the production or utilization of special nuclear material or atomic energy" as recited in Section 152 of the Atomic Energy Act of 1954" and asks if any support from the Atomic Energy Commission, concludes, "This application will be reached for processing in about FORTY-FIVE DAYS. Final disposition thereof will be expedited if an appropriate statement is filed during this period."

Photocopy of article, "U.S. Approval: Stanford and UC Can License 'Gene-Splicing' by Charles Petit, San Francisco Chronicle, March 14, 1978, no page number provided, "Patent file" handwritten by SNC at top right of page

95 7
Cohen/Boyer patent information, 1978

Signed letter dated December 5, 1978 from Bertram I. Rowland to SNC and Boyer, cc to Reimers, "BRANSON" handwritten by SNC in margin and above in, in another hand, "Debbie Branson"; text: please sign and return enclosed "Continuation-in-Part Patent Application"; stapled behind this letter is another signed letter, dated December 6, 1979 from SNC to Rowland, text: enclosed is Continuation-in-Part Patent Application "duly signed and notarized"

Undated 40-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", printed double-sided; attached behind it with a butterfly clamp is one sheet of paper with two forms printed on it: 1) on one side is "DECLARATION AND POWER OF ATTORNEY" signed by SNC on December 1, 1978 appointing 21 listed "attorney(s) and/or agent(s) who are partners and associates in the firm of Townsend and Townsend to prosecute this application and transact all business in the Patent and Trademark Office connected therewith" (including Bertram I. Rowland) [unsigned version of same form catalogued in Row 430 and older signed version of slightly different form (13 lawyers listed) catalogued in Row 355] ; 2) on the other side is "ASSIGNMENT" signed by SNC on December 1, 1978 and notarized by Debi Prunier, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 355, 366, and 429]

Signed letter dated December 1, 1978 from SNC to Bertram I. Rowland, cc to Niels J. Reimers, text: "Enclosed are two signed and notarized copies of the continuation-in-part patent application for the recombinant DNA process. You will need to get Herb Boyer's signature separately."; stapled behind it is signed letter from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY NOV 9 1978 TECHNOLOGY LICENSING" with notes handwritten by SNC at top ("Rita Philip 76221") and bottom ("Debby Branson 77950"); text: "Enclosed are two copies of the captioned continuation-in-part application for review by you and the inventors. . . . . On November 7, 1978, we filed continuation application . . . of Application Serial No. 687,430 which was originally filed on May 17, 1976 . . . . The application was directed to the claims to compositions rejected by the Examiner."

Photocopy of nine-page "DECLARATION UNDER RULE 132" signed by SNC on October 28, 1982, "Final 10/28/82" handwritten by SNC at top right of first page

Unsigned 26-page AMENDMENT "In response to the Office Action of August 2, 1982" with signature line for Bertram I. Rowland; "To be revised" handwritten by SNC at top right of first page, on p. 10 is a post-it with illegible handwriting by SNC, on p. 17 is a post-it with "Make too b___ align of Hogness not prior" handwritten by SNC

Signed letter dated October 17, 1978 from Niels J. Reimers to Nature Magazine, cc to SNC, Norman Latker - HEW, Dr. Donald Fredrickson - NIH, at top right "Patent file" handwritten by SNC in pen and crossed out in pencil; text: comments re "article by John Douglas, "U. S. Geneticists Look to Europe for Research Facilities," in the September 21, 1978 issue", 1) lists sources of support for the original research: American Cancer Society, National Science Foundation, National Institutes of Health, University of California, and Stanford; and 2) "The existence of a patent per se does not inhibit research in the U.S. or elsewhere. The only basis on which this particular patent (if granted) might become a factor in the choosing of a site of research is that, as noted earlier in the article, industrial licensees of the patent will be required to follow the NIH safety guidelines for genetic engineering."

Memo dated September 27, 1978 from SNC to Niels Reimers; "I have reviewed your draft of a license agreement for companies . . . . I have no substantive modifications to suggest."; three attachments stapled to memo: 1) Signed memo dated September 19, 1978 from Robert M. Rosenzweig to Niels Reimers, cc S. Cohen, M. Hudnall, G. Lieberman, W. Massy, B. Rowland, Subject: Licenses for Cohen/Boyer work, handwritten by SNC in upper right is "Stanford Patent file"; text: he had reservations about licensing because of concern "that we not worsen the political climate in which the regulation of recombinant DNA research would be handled. My concerns in that area have greatly diminished in recent months as some balance has been restored to the public policy debate. . . . My present view, therefore, is that we should proceed to put into effect the best licensing program we can manage."; 2) Signed memo dated September 14, 1978 from Niels Reimers to SNC, Mike Hudnall, and Bert Rowland, cc to R. Rosenzweig, G. Lieberman, W. Massy, Subject: License for Cohen/Boyer Work; text: "Enclosed is your copy of a very rough first draft of a license for the Cohen/Boyer work. Each draft is numbered, and I would appreciate your not making any further distribution. Please be aware the earned royalty rate that I used is not at all firm. I particularly would like Bert's comments on basing royalties on products which may not be made by our licensee, Mike's comments on "safety guidelines," and Stan's on "End Products." . . . . After another drafting, I will probably go to one or more potential licensees on an informal basis to try it on them. . . . this scenario is of course contingent upon a formal decision by Stanford to license at all"; 3) nine-page "D R A F T AGREEMENT" for licensing Cohen/Boyer work, at top right of p. 1 is handwritten "Copy #3", on p. 3 a handwritten correction by SNC changing date of NIH Guidelines from December 1976 to July 23, 1976, and on same page after typewritten "licensee shall pay to Stanford the sum of" is a large gap in which "fifteen" handwritten by SNC, then typing resumes "thousand dollars . . ."

Signed letter dated June 1, 1978 from Kenneth R. Allen, Townsend and Townsend to SNC and Boyer, cc to Neils[sic] Reimers, at top right handwritten (not by SNC) "opened" and date stamped "JUN 6 1978" and in left margin near bottom handwritten (not by SNC) "Returned 6/8/78"; text, enclosed for signature and return "a further declaration which must be filed in this patent application in order to place it in a condition to be issued to Stanford"; no attachments

Signed letter dated May 2, 1978 from Bertram I. Rowland to SNC, cc to Neils [sic] Reimers, text: enclosed declaration "must be filed in this patent application in order to place it in a condition to be issued to Stanford", please sign and return; handwritten by SNC at bottom, "Please Xerox attached - Return original --> Bert Rowland"; attached is photocopy of two-page RESPONSE UNDER SECTION 152 OF THE ATOMIC ENERGY ACT OF 1954, signed by SNC on May 4, 1978, stating there was no "contract, subcontract or arrangement entered into with or for the benefit of the Nuclear Regulatory Commission" and that Stanford, UC, HEW, the ACS and NSF "all agreed that the invention was to be administered by Stanford"

43-page report, "THE PATENTING OF RECOMBINANT DNA RESEARCH INVENTIONS DEVELOPED UNDER DHEW SUPPORT: An Analysis by the Director, National Institutes of Health November 1977"; first page is photocopy of a letter dated March 2, 1978 from Donald S. Fredrickson to Robert M. Rosenzweig, text includes, " . . . it is my recommendation that at least for the present, recombinant DNA research inventions developed under DHEW-NIH support should continue to be administered within current DHEW patent agreements with the universities."; paper clipped to front of report is small photocopied note dated March 10,1978 from Donald S. Fredrickson, not addressed to anyone,, at top right of note date stamped "MAR 29 1978" and "Patent file" handwritten by SNC, text of note begins, "Enclosed is a copy of an analysis and decision on the patenting of recombinant DNA research inventions developed with DHEW support."

Signed letter dated March 17, 1978 from Niels J. Reimers to Bertram I. Rowland, cc to SNC and Herbert Boyer, "Patent file" handwritten by SNC at top right; Reimers states that the Atomic Energy Commission had no connection to the subject invention; SNC received support from the NIH and Stanford, Boyer was supported by the NSF, ACS and UC, concludes, "Bert, if you happen to find out what applications there are of this technology in "special nuclear material or atomic energy," I would be pleased to find out. I have not read in the literature nor heard from industry that such applications were contemplated or possible."; two attachments: 1) Signed letter dated March 14, 1978 from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY MAR 15 1978 TECHNOLOGY LICENSING" asking for information on "sources of support for the subject invention", Rowland will then prepare statements for SNC and Boyer to sign; 2) USPTO communication "FILED May 17, 1976" from Benjamin R. Padgett, Special Laws Administration Group, sent to Townsend & Townsend, date stamped in upper left corner "PAT. & T.M. OFFICE MAILED FEB 1 1978 SECURITY GROUP LICENSING & REVIEW", also stamped at top of page, "RECEIVED 1978 FEB 16 PM 3:05 TOWNSEND & TOWNSEND", text states, "The subject matter of this application appears to be "useful in the production or utilization of special nuclear material or atomic energy" as recited in Section 152 of the Atomic Energy Act of 1954" and asks if any support from the Atomic Energy Commission, concludes, "This application will be reached for processing in about FORTY-FIVE DAYS. Final disposition thereof will be expedited if an appropriate statement is filed during this period."

Photocopy of article, "U.S. Approval: Stanford and UC Can License 'Gene-Splicing' by Charles Petit, San Francisco Chronicle, March 14, 1978, no page number provided, "Patent file" handwritten by SNC at top right of page.

95 8
Cohen/Boyer patent information, 1978

Binder clip holding three sets of documents, each group held together with a butterfly clamp. First butterfly clamp holds four items: 1) Photocopy of nine-page "DECLARATION UNDER RULE 132" signed by SNC on October 28, 1982

2) article by S.N. Cohen and A.C.Y. Chang, J. Bac., 1977

3) article by S. Chang and S.N. Cohen, PNAS, 1977

4) first page of article by S.N. Cohen et al., PNAS, 1973

Binder clip holding three sets of documents, each group held together with a butterfly clamp. Second butterfly clamp holds nine items: 1) last four pages of article by S. Chang and S.N. Cohen, PNAS, 1977

2) unsigned letter dated September 5, 1974 from SNC to Dick Roblin, Mass. General listing 32 people who have requested and received the pSC101 plasmid

3) unsigned two-page letter dated September 6, 1977 from SNC to Donald Fredrickson, Director, NIH enclosing a manuscript [not included in this file] in press with PNAS, "I have taken the unusual step of sending it to you prior to publication because I believe the findings have policy, as well as scientific, importance with regard to the regulation of recombinant DNA", " . . . along with virtually all of the other scientists who first raised these questions, I have since come to believe that our initial concerns were greatly overstated."

4) photocopy of two-page "DECLARATION UNDER RULE 132" signed by Herbert W. Boyer on October 21, 1982

5) photocopy of Gordon Research Conferences "Frontiers of Science" Application to attend "Conference on extrachromosomal Elements" July 6-10, 1981 at Tilton School, signed by Christine Miller on April 2, 1981

6) photocopy of three-page "DECLARATION UNDER RULE 132" signed by Stanley Falkow on October 22, 1982

7) article by Guerry, Van Embden and Falkow, J. Bac., 1974

8) three-page "DECLARATION UNDER RULE 132" signed October 1, 1982 by Bernard Weisblum

9) first three pages of article by Tanaka and Weisblum, J. Bac., pp. 354-362, 1975 (the rest of the article is in butterfly clamp catalogued in next row)

Binder clip holding three sets of documents, each group held together with a butterfly clamp. Third butterfly clamp holds 18 items: 1) last six pages of article by Tanaka and Weisblum, J. Bac., pp. 354-362, 1975 (first three pages is in butterfly clamp catalogued in previous row)

2) photocopy of two-page "DECLARATION UNDER RULE 132" signed by David S. Hogness on October 27, 1982

3) photocopy of three-page "DECLARATION UNDER RULE 132" signed by Donald R. Helinski on October 27, 1982

4) article by Hershfield, Boyer, Yanofsky, Lovett, and Helinski, PNAS, 1974

5) photocopy of four-page "DECLARATION UNDER RULE 132" signed by Bertram I. Rowland on October 29, 1982

6) unsigned letter dated October 25, 1979 from Bertram I. Rowland to Robert B. Helling, cc to Niels Reimers, "11/5" handwritten at bottom right of first page

7) almost illegible photocopy of "____ Withholding Exemption Certificate" and "Patent Agreement" stamped "RECEIVED GRADUATE DIVISION SAN FRANCISCO JUL 13 1972" signed by Robert B. Helling and Administrative Assistant H. Kay Stewart on July 6, 1972

8) U.C. Employment Form signed by Robert B. Helling on July 6, 1972, "Dr. Robert Helling is an Associate Professor from the University of Michigan, Ann Arbor, here on a year's sabbatical doing special research with Dr. H.W. Boyer. He is a Special Fellow with the NIH."

9) Page 1 of Dept. of Health, Education, and Welfare Public Health Service Facilities and Commitment Statement for Research Fellowship, comments of Sponsor, " . . . During his sabbatical leave I expect Dr. Helling to participate in one area of our research program designed to elucidate the mechanism of DNA-protein interaction. . . ."

10) another photocopy of form catalogued above in 8)

11) Dept. of Health, Education, and Welfare Public Health Service Research Fellowship Activation Notice re Fellow Robert B. Helling, award period "From 6/11/72 Through 8/10/73 (14 Months)", signed by Helling on June 12, 1972 and by Herbert W. Boyer on June 14, 1972

12) Dept. of Health, Education, and Welfare Public Health Service Notice of Research Fellowship Award to Robert B. Helling, sponsor Herbert W. Boyer, date issued May 26, 1972

13) another photocopy of form catalogued above in 11)

14) U.C. Change in Employment Status signed by H. Kay Stewart for Robert B. Helling "From 7/1/83 Through 8/31/73" without salary, "He is staying an additional two months to complete his research project."

15) Dept. of Health, Education, and Welfare Public Health Service Notice of Research Fellowship Award to Helling, date issued July 25, 1972

16) almost illegible photocopy of Robert B. Helling's Report of Gift Acceptance, date gift received July 31, 1972, "Your application for a Public Health Service Research Fellowship has been approved"

17) Dept. of Health, Education, and Welfare Public Health Service Research Fellowship Termination Notice regarding Robert B. Helling, scheduled termination date, August 10, 1973, summary of research undertaken lists Cohen, Chang, Boyer, and Helling, PNAS in press

18) SNC article, "The Stanford DNA Cloning Patent", 1982

95 9
Cohen/Boyer patent information, 1979

Unsigned copy of a four-page letter dated October 25, 1979 from Bertram I. Rowland to Robert B. Helling, cc to Niels Reimers; four markings near top of p.1 1) date stamped "STANFORD UNIVERSITY OCT 26 1979 TECHNOLOGY LICENSING", 2) handwritten "xcc Cohen Ditzel 1. JKP 2. S74-43", 3) a second date stamp at top of p. 1, "OCT 30 1979", and 4) "patent file" handwritten by SNC; letter begins, "Thank you very much for the courtesy of your conversation. Enclosed with this letter is a copy of the claims which are presently before the Patent Office, the claims having been rejected primarily because of the prior publications by the inventors in conjunction with others. As I explained to you, it has been Patent Office policy to treat a publication which includes an inventor as a reference as prima faciae [sic] evidence of co-inventorship. The burden then shifts to the applicant to establish that the co-authors are also not co-inventors. However, if a co-author will not cooperate, then the applicants must seek judicial help in requiring the co-author to prove that he is also a co-inventor. I think you will agree with me that this Patent Office policy has no real basis in fact, since considerations of inventorship based on patent principles are rarely involved in the considerations of co-authors. The concept of an inventor is a legal concept which is based on certain factual inquiries." Rowland outlines his understanding of the facts for approx. two pages, then "If after reading this letter, you still believe that you should be accorded inventorship, I would greatly appreciate it if you would write down the contributions you feel you made toward the ultimate success of the development as presently claimed. . . . In the alternative, after reconsideration if you believe you are not a co-inventor, I would greatly appreciate your signing a Disclaimer of Co-Inventorship as to the accompanying claims. Purely from my own personal viewpoint, if you truly believed yourself an inventor, you had the opportunity to file a patent application in your name in conjunction with the others whom you deemed were co-inventors. . . . At the present time, unless the Patent Office withdraws its rejection, the application will have to go to appeal. I believe the only course of action left to the applicants is to file a cause of action in the District of Columbia requesting the Court to order the Commissioner to issue the patent and deposing you, so that we can once and for all determine all the facts and obtain a judicially sanctioned inventive entity."; at end of letter, "Enclosures 1. Claims 1-17 2. Disclaimer", but no attachments to this copy of letter; another copy of this letter catalogued above

Signed letter dated October 2, 1979 from Bertram I. Rowland to Niels J. Reimers, cc to SNC and Boyer, stamped "OCT 3 1979" at top of page and "Patent file" handwritten by SNC at top right; text re proposed letter to Helling enclosed for comments or suggestions, when Rowland spoke to Helling, "by the end of the conversation, he seemed to be willing at least to rethink his position albeit reluctantly. I therefore have indited the enclosed epistle in the hopes that the gospel according to St. Bertram may have some positive effect."; two attachments: 1) unsigned, undated four-page draft of letter from Rowland to Helling, and 2) five pages of undated text which begins, "WHAT IS CLAIMED IS:" and describes 17 claims

Photocopy of three-page "DECLARATION UNDER RULE 131" signed by SNC on February 7, 1980, but not signed by Boyer, stamped "COPY" at top left, and "patent file" handwritten by SNC in upper right, post-it on front page with handwritten note, "from: Bert Rowland To: Dr. Cohen", on p. 2, line 19 the word "kanamycin" has been crossed out in pencil and "TC" handwritten above it; attached are five photocopied, undated lab notebook pages with handwritten notes by Annie Chang (same pages as in document catalogued in Rows 272 and 273)

Photocopy of nine-page "THIRD PRELIMINARY AMENDMENT" signed by Bertram I. Rowland on May 9, 1979, handwritten at top of p.1 "xcc Stan Cohen Roger Ditzel 1. JKP 2. f S74-43" and in SNC's handwriting "Patent file"

Two-page signed letter dated April 9, 1979 from Paul D. Flehr of Flehr, Hohback, Test, Albritton & Herbert to Niels J. Reimers, three markings near top of p.1 1) date stamped "STANFORD UNIVERSITY APR 10 1979 TECHNOLOGY LICENSING", 2) handwritten "xcc Herzenberg Rowland Hudnall Cohen S74-43 S77-17", 3) "Patent file" handwritten by SNC; "Since our letter of March 23, we have received letters from our Japanese and German associates with respect to patents in foreign countries covering microorganisms and their processes. . . . the Japanese Patent Office has recently prepared examination standards on this matter. . . . According to my interpretation, the Japanese standards will permit the patenting of new microorganisms and processes for producing them. . . . In all probability these standards will be used in other foreign countries, and therefore it is suggested that you keep them in mind in preparing and filing new applications.", quotes their German associate:, "in Germany (and as far as I am informed also in other Euorpean [sic] countries as well) new microorganisms and microbiological processes may be patentable . . . ."; attachment: unsigned letter dated "March, 1979" from Nakamura, Yamamoto, Takeda and Partners to "Gentelemen" [sic], "Enclosed is an English translation of the revised part of the Examination Standard. Although the revision is still referred to as a proposal, it is almost certain to be formally adopted in the near future and applied to all applications."; attached to the attachment is a six-page English-language "Examination Standard Relating to Inventions of Microorganism Per Se" from "Office of Examination Standards"

Four-page signed letter dated February 8, 1979 from Paul D. Flehr of Flehr, Hohback, Test, Albritton & Herbert to Niels J. Reimers, cc to Bertram I. Rowland, three markings near top of p.1 1) date stamped "STANFORD UNIVERSITY FEB 9 1979 TECHNOLOGY LICENSING", 2) handwritten "xcc Cohen 1. JKP 2. S74-43", 3) "File" handwritten by SNC; nine paragraphs summarizing February 2 conversation with Bert Rowland re "the various Cohen et al. applications" and seven paragraphs summarizing subsequent conversation with "Tom Kiley of Lyon & Lyon about his experiences in this field."

95 10
Cohen/Boyer patent information, 1980

Signed memo dated December 19, 1980 from SNC to Donald Kennedy, SUBJECT: Recombinant DNA Patent; re licensing the patent: ". . . . The purpose of this memo is to urge that the University charge a very low royalty rate (no more than 0.5 percent) for such licenses. I strongly support the view that the University license rate should be low enough to encourage industrial organizations to sign up, rather than fight the very broad patent or take their operations outside of the United States where the patent does not apply. The more companies that sign up, the more unlikely it will be that other organizations will be inclined to challenge the patent or will be successful in doing so . . . the basic patent underlies an entire industry having enormous potential for generating income for the University. . . . with even a 0.5 percent royalty, the University will do well, and will in fact maximize the likelihood of financial success with the patent . . . "

Two-page news release "mailed December 3, 1980" from Stanford University Medical Center News Bureau, no title; first sentence: "A broad patent covering the novel gene splicing and cloning methods developed by scientists at Stanford University School of Medicine and the University of California in San Francisco has been issued by the U.S. Patent Office in Washington.", News Bureau contact Spyros Andreopoulos; at right top of first page "12/3/80" handwritten and "file" handwritten by SNC

Handwritten memo dated December 2, 1980 from Niels Reimers "TO THE FILE", cc to SNC, "Subject: call from Bert Rowland", in upper right date stamped "DEC 5 1980" and "file" handwritten by SNC; completed text: "Method" patent allowed!-- assigned #4237,224. Product patent appl still in negotiation. Pressure on examiner to complete neg. so patent can be used as reference in other pending gene splicing cases."

Patent 4,237,224 printed on 7-3/4" X 11-3/8" paper

Photocopy of Patent 4,237,224 copied onto 8-1/2" X 11" paper; "With best wishes, Stan Cohen" handwritten by SNC at bottom of first page; large post-it on first page has "Hold for letter to Tom Kiley" handwritten by SNC

Signed two-page letter dated September 4, 1980 from Niels Reimers to M. Mangyo, Mitsubishi Chemical Industries Limited, bcc to SNC and H. Kaplan, in upper right "file" handwritten by SNC and also a date stamp "SEP 8 1980" with the "8" crossed out and "9" written above it; "Thank you for your letter of August 21 with accompanying information describing the Mitsubishi-Kasei Institute of Life Sciences. As you may be aware, we have had patent applications on file in the area of genetic engineering for some time. . . . Pending issuance of those patents for the Cohen/Boyer work, we have not developed licensing plans for subsequent discoveries including the invention by Nunberg, Chang et al (Japanese Patent application #130718/1979). We have found that for patents in the pharmaceutical industry, exclusive licenses usually are necessary to encourage development at private risk to products available to the public. However, for basic discoveries such as the Cohen/Boyer patents, we plan to license them non-exclusively.", also discusses hybridoma technology and upcoming Kaplan, Olsson paper in PNAS, "A patent application is on file, and we plan to issue non-exclusive licenses.", and re question about royalties, "For the basic Cohen/Boyer process, the royalties will be less than 1% ", for hybridoma license "royalties will likely by 2% ", and "For other developments, the royalties will likely be greater as we would anticipate issuing exclusive licenses in many instances."

Unsigned letter dated August 26, 1980 from Niels J. Reimers to Phil Tracy, Burroughs Wellcome Co., cc to Adrian Arima and SNC, at top is date stamp, "AUG 28 1980" and in upper right "file" handwritten by SNC; text begins, "Attached is the Interferon License Agreement, which you will note includes the changes that we had discussed, except for the "combination product." . . . "; at bottom is typewritten: "blind note to Stan: We need the invention assignment signed by you and your colleagues before we can proceed further. NJR", "Niels" handwritten next to typed "NJR"

Unsigned two-page letter dated March 6, 1980 from Bertram I. Rowland to Niels J. Reimers, cc to SNC and Boyer, at top is date stamp, "MAR 7 1980" and in upper right "file" handwritten by SNC; "TELECON WITH DICKSON OF NATURE RE: APPLICATION STATUS"; received phone call March 4 from Mr. Dickson of Nature "who indicated he had tried to reach you and had been unable to. He further informed me, that he was inquiring about the status of the patent applications filed on behalf of Cohen-Boyer. . . he believed there was a problem concerning inventorship. I asked him whether he had been in contact with Professing[sic] Helling, to which he did not respond.", Rowland says he believes Dickson had read his letter to Helling, and continues recapping talk "My primary points were that while the Patent Office had raised the issue of authorship, I believed it could be handled in the Patent Office with the Examiner. If we were unsuccessful in that effort, then we might have to go to Court, . . .", told Dickson "Helling had done nothing to support his statement that he was a co-inventor, rather he was acting merely as a spoiler.", also "I further stated, that the situation with molecular biology was an excellent opportunity for the universities to realize some return on their substantial investment in support of research in the area. . . . I reiterated a few times concerning Helling that "Helling is an honorable man." I further requested that I not be quoted in the article. . . Before talking to Mr. Dickson, I think it would be appropriate for you and me to have a conversation."

Three memos stapled together: 1) Signed memo dated February 12, 1980 from SNC to Niels Reimers, "I have heard several different versions of what the "new policy" for distribution of royalties might be. . . . and that some potential obstacles have arisen to the earlier proposal to have the portion currently received by the University "General Fund" go instead to the School of Medicine. . . . I am reluctant to enter into still another major royalty distribution agreement in the absence of a decision on the royalty matter." asks for info re timetable for resolution, at below typewritten text is handwritten note, not by SNC, "(no encl.) attached only for our info."; 2) Signed memo dated September 14, 1979 from SNC to Donald Kennedy, Provost, cc C. Robertson, A. Michaels, G. Lieberman, L. Crowley, "This memo is to indicate my understanding of your proposal regarding patent royalties." next 16 lines of memo provide details, then "Thus, distribution of patent royalties will continue "as is" except that the current "University" share will go entirely or in major part to the Medical School. On the basis of this above understanding, I am prepared to proceed in good faith with assignment of rights in connection with the Michaels, Robertson, Cohen project."; 3) Signed memo dated September 20, 1979 from Donald Kennedy, Provost to SNC, cc to L. Crowley, G. Lieberman, A. Michaels, C. Robertson, at top is date stamp, "SEP 24 1979" and in upper right "Patent" handwritten by SNC; text: 9/14 memo "is entirely in accord with my understanding of our discussions. I'm fully committed to the actions you list, and I'm glad we're ready to move forward."

Signed letter dated February 5, 1980 from Bertram I. Rowland to SNC and Boyer, "File" handwritten by SNC in upper right; text: enclosed for signature and return to Rowland are two copies of a Declaration under Rule 131 "which I am sending to each of you simultaneously. The Declaration has already been reviewed by Stanley and is hopefully accurate"; two attachments, 1) unsigned three-page "DECLARATION UNDER RULE 131" with signature lines for SNC and Boyer, 2) five photocopied, undated lab notebook pages with handwritten notes by Annie Chang

Signed letter dated January 16, 1980 from Bertram I. Rowland to SNC, "returned 1/31/80" handwritten on side and date stamped "JAN 17 1980" in upper right; text: enclosed is a Declaration under Rule 131 "would you please review and see if all the statement I make are correct."; two attachments, 1) photocopy of unsigned three-page "DECLARATION UNDER RULE 131" with signature lines for SNC and Boyer, and handwritten edits by SNC 2) five photocopied, undated lab notebook pages with handwritten notes by Annie Chang.

95 11
Cohen/Boyer patent information, 1981

Draft of two-page memo dated December 18, 1981 from Niels J. Reimers to SNC, cc at end of memo to Kenneth Melmon, Gerald Lieberman, Larry Crowley, Phil Hanawalt, Donald Kennedy; handwritten at top of first page: "DRAFT STAN -- If this is OK, I'll do a "final": (it isn't possible to transfer funds to gift accounts) Niels 12/21/81" and in SNC's handwriting: "Patent file"; text begins, "Following is the accounting which you requested of the 1981 royalty revenue resulting from licensing of the subject patent and patent application.", also mentions, "The Dean's Fellowship Fund is to be used to establish and support the Bernard Cohen Post-Doctoral Fellowships, in honor of your deceased father."

Unsigned letter dated December 16, 1981 from Roger G. Ditzel, Office of the Board of Patents, Systemwide Administration to Joseph P. Allen, Intellectual Property Owners, Inc., bcc to Neils Riemers [sic], Herbert Boyer, SNC, in upper right of page "file" handwritten by SNC; nominates Boyer and SNC as "Inventors of the Year", pursuant to a call for nominations in the December 1981, IPO News."; stapled behind letter is photocopy of IPO News, December 1981, p.1 with article "Entries sought for 'Inventor of the Year'", no author listed

Signed letter dated December 11, 1981 from Bertram I. Rowland to SNC, in upper right date stamped "DEC 12 1981" and "File" handwritten by SNC; text: ". . . Enclosing my proposed response to the patent office", deadline is December 18, " . . . If I do not hear from you by that time, I will automatically mail the response as is."; attached is unsigned 11-page "AMENDMENT" with signature line for Bertram I. Rowland and handwritten edits by SNC (some on back of sheet)

Signed memo dated December 7, 1981 from SNC to Niels Reimers; request for $62.00 (train and taxi fares) reimbursement for visit to U.S. Patent Office where he spoke with patent examiner Alvin E. Tanenholtz SNC thought discussion "was useful, and hopefully will facilitate the allowance of our claims."; attached is photocopy of December 2, 1981 Amtrak Passenger Receipt for $26.00, signed by SNC

Photocopy of 1981 INVENTOR OF THE YEAR AWARD from Peninsula Patent Law Association to SNC and Herbert W. Boyer for Patent 4,237,224

Signed memo dated November 5, 1981 from SNC to Niels Reimers; would like to have royalty "funds received in 1981 credited to my accounts of this year and then transferred to the University funds before December 31."

Photocopy of article, date stamped at top "OCT 1 1981", "file" handwritten by SNC in upper right, "Stanford to License Gene-Splicing Technique", no byline, Scientists Inst. For Public Information, July-August 1981, p. 6.

USPTO action cover sheet "DATE MAILED SEP 18 1981" from A.E. Tanenholtz to Bertram I. Rowland; Part I states that "Notice of References Cited by Examiner, PTO-892 is attached, Part II lists pending and rejected claims; two attachments: first a signed six-page opinion dated September 17, 1981 by Alvin E. Tanenholtz, Primary Examiner, and second a two-page Notice of References Cited, listing five references, dated September 14, 1981 and signed by Examiner Tanenholtz

To Examiner: A.E. Tanenholtz "In re the application of JACK N. NUNBERG, et al, Serial No. 950,100", four-page AMENDMENT signed on behalf of Bertram I. Rowland on June 9, 1981

Page 22 of 25-pagedisclosure "PROTEIN PRODUCTION AT SYNTHETIC START SITE" described in Row 246 of this spreadsheet; text of P. 22 begins, "WHAT IS CLAIMED IS: 1. A method for providing for the production in a unicellular host of a protein foreign to said host . . . "

Signed letter dated October 26, 1979 from "(Ms.) Ronni Lipsius, Foreign Department Townsend and Townsend" to Niels J. Reimers; date stamped "STANFORD UNIVERSITY OCT 29 1979 TECHNOLOGY LICENSING"; in upper right of page handwritten "xcc Cohen F ____", date stamped "NOV 1 1979" and "Patent file" handwritten by SNC; text says re "Serial No.: 79302019.9, Filing Date: September 27, 1979, Country: EPO (Belgium,France,W.Germany, Italy, Luxembourg,Netherlands,Sweden & Switzerland) For: Protein Production at Synthetic Start Site", "application has been officially filed and assigned a serial number in the Patent Office of the country indicated."; post-it attached to letter with "Save for my trip east." handwritten by SNC

Sheet of lined yellow paper with handwriting by SNC, "Pat -- get copy of my original patent & examiner's initial denial--and return to me with the attached. S."; below in another hand, "ribosomonial [sic] start site"

USPTO action cover sheet re Serial Number 950,100, Filing Date 10/10/78, First Named Applicant Jack H. Nunberg et al" "DATE MAILED OCT 7 1981" from A.E. Tanenholtz to Townsend and Townsend; "This action is made final."; Part I of form is unmarked, Part II lists Claims 6-11 withdrawn and Claims 1-5 rejected; attached is a two-page opinion dated September 16, 1981 by Alvin E. Tanenholtz, Primary Examiner with handwritten notes by SNC

pp. 23-25 followed by pp. 1-21 of 25-page disclosure "PROTEIN PRODUCTION AT SYNTHETIC START SITE" p. 22 is filed separately and described in Row 238 of this spreadsheet; at top of page 1, "SNC Patent file" handwritten by SNC; p. 1: "BACKGROUND OF THE INVENTION";.2: "SUMMARY OF THE INVENTION", p. 3: "DESCRIPTION OF THE SPECIFIC EMBODIMENTS", p. 13: "EXPERIMENTAL", p. 25: "ABSTRACT OF THE DISCLOSURE"

Two-pages of graphics, "Applicable Overhead Cost Pools � MDTC of Each Univeristy [sic] Functions = Rate; first page depicts, "PRE- A-21" and second page depicts, "POST- A-21"

Memo dated September 1, 1981 from Andy Barnes to Niels Reimers, "copies sent by TFM to:" Robert Beyers, Donald Kennedy, Gerald Lieberman, William Massy, Kent Peterson, cc to Stanley Cohen, Roger Ditzel, Laura Hofstadter, OTL Staff, date stamped "SEP 2 1981", "SUBJECT: Cohen-Boyer Gene-Splicing License"; text begins: "Today, the Green Cross Corporation of Osaka, Japan, became the first company to sign our gene-splicing license agreement.", rest of memo provides details

Signed memo dated August 25, 1981 from SNC to Lawrence G. Crowley, cc: Niels Reimers, "SUBJECT: Inventor's share of royalties from the recombinant DNA patent"; text, "I have been informed by Niels Reimers that the University expects to begin receiving funds during the next several months from firms licensing the recombinant DNA patent. As you know, I have specified that half the inventor's share of royalties be assigned at present to the Dean's Fellowship Fund in the Medical School, and that the other half be assigned to the General Research Fund of the University. I am writing now to ask that the Dean's Fellowship funds received from my patent royalties be used to establish and support the Bernard Cohen Postdoctoral Fellowships. . . . in honor of my deceased father."

Two photocopies of signed memo dated August 20, 1981 from SNC to Niels Reimers, "SUBJECT: Recombinant DNA patent"; requesting original patent document: "I wondered whether you have followed up with Bert Rowland the possibility that the original patent document issued by the Patent Office on the Recombinant DNA method could be given to me."

Photocopy of Nature, Vol. 292:485, August 6, 1981, containing article, "Stanford sells gene-splicing licences" by David Dickson; "Boyer Cohen patent" handwritten by SNC at top right

Photocopy of clipping of article, "Genetics engineers upset by licences," "By the staff of Nature", handwritten at top is "copy--Stan Cohen THE TIMES AUGUST 6, 1981 [no page number provided] TO --> Reimers" and handwritten by SNC in upper right corner: "Patent file"; article begins, "Stanford University, in Palo Alto, California, has startled the new biotechnology industry by advertising for applications for licences to use the patents it hold, jointly with the University of California at Los Angeles [sic], on some of the basic operations of genetic manipulation. The advertisement appears among the small ads in next week's Nature. The legal implications of this development are far from clear. . . "

Three-page advance of press release draft dated July 29, 1981, "FOR RELEASE MONDAY, AUGUST 3, 1981", Contacts: Bob Beyers or Laura Hofstader, "file" handwritten by SNC at top left; text begins, "An unprecedented effort to license the entire genetic engineering industry for use of its basic scientific technique has been started by Stanford's Office of Technology Licensing."; Stanford president Donald Kennedy quoted, "Funds generated through this licensing program will help replenish the basic research enterprise"; Niels Reimers quoted, "So far as I know, there's no precedent for this sort of license"; two handwritten edits by SNC: 1) "The invention itself stemmed from scientific collaborations begun by Cohen and Boyer in a Waikiki delicatessen in November 1972." changed to " . . . begun by a discussion between Cohen and Boyer in a Waikiki delicatessen . . ." and 2) "At first, Cohen didn't think the basic invention was patentable." changed to ". . . didn't think the basic invention should be patented."

Unsigned letter dated July 7, 1981 from Andrew C. Barnes to Stephen Goulden, Cetus Corporation, cc to Stan Cohen, date stamped "JUL 9 1981"; "Please find enclosed a copy of the latest draft of the Cohen/Boyer License Agreement for your information. The underlined portions in the agreement indicate items which have changed since the previous draft. . . . we plan to publicly announce the terms of the license at the end of this month."

Signed memo dated June 24, 1981 from Niels J. Reimers to SNC, in upper right are date stamp "JUN 29 1981" and "file" handwritten by SNC; "This is a very belated reponse [sic] to your request for the "original" of the patent of you and Herb Boyer. I had been advised that we must keep the original on file until the patent expires in the event of disputes regarding the patent. . . . the next time I make contact with a Patent Office official . . . I will see if there is a way around that requirement and let you know what I find out."

Signed memo dated May 13, 1981 from SNC to Niels Reimers, SUBJECT: DNA Patent, "file" written in upper right (not SNC's handwriting); " . . . Although the rights to this patent have been assigned to the University, as the inventor, I should like to have and keep as a souvenir the patent document itself. . . "

Signed memo dated May 13, 1981 from SNC to Niels Reimers, CC to L. Crowley, SUBJECT: Royalty Distribution for Recombinant DNA Patent"; text: " . . . Dr. Crowley's approval of the revised distribution of the department share of the recombinant DNA patent income was prospective, and was in the form of a statement he made to me indicating that he would go along with whatever arrangement Ken Melmon and I worked out with each other. My statement to you about Dr. Crowley's approval was not intended to imply that he had reviewed the outcome of the discussions that Ken Melmon and I have held on this matter."

Signed memo dated April 28, 1981 from Niels J. Reimers to Bob Vandagriff, cc to K. Melmon, L. Crowley, G. Lieberman, K. Carpenter, in upper right "SNC" handwritten by Karen Carpenter and "Patent file" handwritten by SNC; text re royalty distribution, Melmon and SNC have agreed, with approval of Crowley and Lieberman, "that the "department share" should be split equally between the Department of Medicine and the Department of Genetics"; summarizes "distribution of "net revenues" (as net revenues are defined in the attached Agreement Concerning Rights in Invention dated 19 June 1975)."; memo has two attachments: 1) signed memo dated March 27, 1981 from Kenneth L. Melmon to Niels Reimers, cc to Gerald Lieberman, Lawrence G. Crowley, SNC, date stamped "STANFORD UNIVERSITY MAR 31 1981 TECHNOLOGY LICENSING" and in bottom right handwritten (not by SNC) "p. 45 Faculty Handbook"; text relates that Melmon and SNC have "come to a reasonable conclusion that the funds generated from his recombinant DNA patent should be split 50/50 between the Department of Medicine and the Department of Genetics for the indefinite future. My hesitation in regard to the long-term future split with the Department of Genetics was no longer justified when I found that the inventor, indeed, does retain all rights to the patent. . . "; and 2) four-page "AGREEMENT CONCERNING RIGHTS IN INVENTION" dated June 19, 1975 between SNC and the Board of Trustees of the Leland Stanford Junior University, signed by SNC and Niels Reimers, at top right of first page handwritten, "S74-43" and at bottom right "original in safe 7/24/75" (neither written by SNC), on p. 3 refers to "the agreement between Stanford and the Board of Regents [of the University of California] dated August 29, 1975", the Department of Genetics is not mentioned in this document, which says net royalties go 1/3 SNC for distribution equally to Stanford's Research Development Fund and School of Medicine Dean's Fellowship Fund; 1/3 to the Department of Medicine; and the final 1/3 "shall be expended in the discretion of the Board of Trustees to further the objects and purposes of Stanford"

Signed memo dated February 4, 1981 from Donald Kennedy to SNC, Subject: Cohen-Boyer Patent, date stamped "FEB 6 1981"; Kennedy understands Reimers "has been in touch with you on his views on the royalty rate for licenses", that R's proposal is agreeable to SNC, and" that it has the property of flattening out at 1/2%, as you suggested. I, too, agree to his proposal and I believe that it accomplishes our objective of getting the scientific results out to the world as quickly as possible, and generating a fair return to Stanford."; handwritten by SNC at bottom of page, "Feb. 9, 1981 Discussion with Neils [sic] today indicates that initial royalties are 1% reduced to 0.75% > 10 X 106. Further reduction to 0.5% with higher volume. I indicated that I thought 0.5% across-the-board might be better but am not going to push. SNC"

Signed memo dated January 30, 1981 from Niels Reimers to SNC, cc to Kenneth L. Melmon, K.J. Carpenter; request that department's share of royalties be divided equally between Depts. Of Genetics and Medicine, "At the present tie, the departmental share of royalties is assigned entirely to the Department of Medicine, although I currently hold appointments in the two departments."

Signed memo dated January 19, 1981 from Donald Kennedy to SNC, date stamped "JAN 23 1981"; reply to SNC's "memo of December 19th concerning the Cohen-Boyer patent. I welcome your thoughtful advice that Stanford should charge a very low royalty rate for licenses related to this patent. . . . and I am in the process of attempting to get Niels Reimer's view on the right magnitude."

Issue of The Blue Sheet and its Supplement, Vol. 24, No. 1, January 7, 1981; Upper right of Supplement cover has "Patent file" handwritten by SNC; Supplement contains "COMPLETE TEXT OF STANFORD's DNA PROCESS PATENT", pp. S-2 - S-14.

95 12
Cohen/Boyer patent information, 1982

Unsigned form letter template from Katharine Ku to "[Adr]", cc to Roger Ditzel - UC, Adrian Arima - SU, Lucy Petitt - NSF, Leroy Randall - HHS, S. Cohen - SU, K. Ku - SU, "file" handwritten by SNC at top right, date stamped "JAN 4 1983", post-it attached with "file" handwritten by SNC, text begins, "We wish to verify the Patent Office has been asked to close the public patent prosecution process on the Cohen/Boyer "product" patent application. . . . your license covers both the issued "process" patent and any patent resulting from the "product" patent application."

Signed letter dated 15 December 1982 from Peter Newmark, Nature to SNC; text re Helling inventorship claims, concludes, "I am disappointed for our sake but glad for yours that discussion has now been driven underground."

Signed letter dated 6th December, 1982 from R.S. Crespi, Patents Controller, British Technology Group to Niels Reimers; at top of page handwritten "xcc/incl attach to Cohen Rowland Rosenzweig 3 file S74-43", date stamped "STANFORD UNIVERSITY DEC 10 1982 TECHNOLOGY LICENSING" and in SNC's handwriting "Patent file"; thanks for review of my book which appeared in TIBS, same issue contains "short article of mine on some basic patent points which I have illustrated by reference to Cohen-Boyer. I have tried to be quite neutral on the issues on your case, especially as I am not expert in your law."; attached photocopy of article, "Current issues in patent law" by R.S. Crespi, TIBS, December 1982, page numbers missing

Photocopy of article, "Biotechnology patent challenged" by Stephen Budiansky, Nature, Vol. 300, p. 303, November 25, 1982; re Robert, in upper right "Patent file" handwritten by SNC

One-page memo dated November 19, 1982 from Niels J. Reimers to Deborah Shapley, Editor, Nature Magazine, has "file" handwritten by SNC in upper right re Nature article "about Stanford's response (on the "second Cohen-Boyer patent") to the U.S. Patent Office (Nature, 11 November, p. 95), one is struck by the editorializing by the author . . . . the article makes it appear the universities have deliberately sought to exclude Dr. Helling from being a co-inventor. The facts are these.", then presents Stanford's and UC's position; stapled in front of memo is small sheet with OTL letterhead, date stamped "NOV 24 1982", typewritten "11/23/82 To: S. Cohen R. Ditzel B. Rowland For your files" signed K. Ku and handwritten below that: "Dr. Cohen -- I assume you received the full copy of the Response K2"

Issue of McGraw-Hill's Biotechnology Newswatch, Vol. 2, November 15, 1982; on p. 1 date stamped "NOV 29 1982", handwritten by SNC in upper right is "patent file"; on p. 5 article "Stanford's attorney yields no ground in rebutting rejection of second Cohen-Boyer patent application", no byline, handwritten by SNC in upper right of p. 5 is "patent file"; from 1st paragraph of text, "The response, prepared by Palo Alto patent attorney Bertram Rowland, with some assistance from co-inventor Stanley Cohen, attempts to shoot down the complex legal points raised by patent examiner Alvin Tanenholtz, without conceding a single one of 30 claims the application makes to products that results from the gene-splicing invention."

Unsigned letter dated November 9, 1982 from Katharine Ku to Editor, Stanford Daily; re November 8 article, "University Reapplying for Cloning Patent" . . . "I would like to correct and clarify a few specific points" then three paragraphs of text; stapled in front of letter is smaller sheet of OTL letterhead date stamped "NOV 15 1982", handwritten, "11/12/82 Dr. Cohen: Here's a copy of the letter I sent to the Editor -- they apparently deleted one paragraph because of lack of space. Niels & I feel it's best to drop the topic at this point -- Hope that is satisfactory to you Kathy Ku"; stapled on top of this is a newspaper clipping, "Cloning patent" by Katharine Ku, which is missing the second paragraph of text from Ku's letter

Issue of Nature, Vol. 300, November 11-17 1982

Clipping of article, "University defends patent on gene splicing, cloning", no byline, Campus Report, November 3, 1982, pp. 1,17. " File Cohen-Boyer Patent file" handwritten at top of article by SNC

Two-page draft of news article on letterhead of Stanford University Medical Center News Bureau with date "Nov. 1, 1982" at end, text contains handwritten spelling corrections (not in SNC's handwriting), the final version of this article appeared in Campus Report on November 3, 1982; handwritten at top "11/1/82", date stamped "NOV 5 1982" and "file" handwritten by SNC; business card of Spyros Andreopoulos stapled to top left; only edits to text are four corrections of typos, not in SNC's handwriting

Two-page memo on green tissue paper dated October 5, 1982 from Niels Reimers to Arthur Kornberg, handwritten at top right: "Stan -- FYI & ___ [looks like f13]. I think you were one I told a "penicillin myth". Niels 10/20/82; memo starts, "Thank you very much for the loan of In Search of Penicillin by David Wilson. . . . "There is an element of truth also with respect to the anti-patent position of some British scientists, but the ultimate reason patents were not filed was a matter of bureaucracy, not principle. . . . A frequent complaint of U.K. university scientists today is that they must delay publication because of patent matters. As you know, we have not, and will not, ask or encourage Stanford scientists to delay publication."

Letter dated October 25, 1982 from Bertram I. Rowland to SNC, "File" handwritten by SNC; enclosing "two copies of the declaration we discussed to be filed in the subject application" for review, signature and return; two copies of nine-page "DECLARATION UNDER RULE 132" attached, the first one has handwritten edits by SNC, also attached is manila envelope addressed to Rowland

Binder clip holding unsigned letter dated October 14, 1982 from Bertram I. Rowland ("dictated but not read") to Niels J. Reimers cc to SNC; enclosed is "proposed draft of a response to the Office Action in the subject application", Dave Hogness "informs me he has documentation which establishes his possession of pSC101 prior to November 4 . . . a declaration by Dave will be added."; attached are amendment and six declarations: 1) 19-page unsigned AMENDMENT with signature line for Rowland and handwritten edits by SNC, 2) unsigned nine-page "DECLARATION UNDER RULE 132" with signature line for SNC, 3) Unsigned two-page "DECLARATION UNDER RULE 132" with signature line for Herbert W. Boyer, 4) Unsigned three-page "DECLARATION UNDER RULE 132" with signature line for Stanley Falkow, with a handwritten comment by SNC, 5) Three-page "DECLARATION UNDER RULE 132" signed October 1, 1982 by Bernard Weisblum, 6) Unsigned three-page "DECLARATION UNDER RULE 132" with signature line for Donald Helinski, 7) Unsigned four-page "DECLARATION UNDER RULE 132" with signature line for Bertram I. Rowland

Signed letter dated September 14, 1982 form Bertram I. Rowland to SNC, in upper right date stamped "SEP 16 1982" and "file" handwritten by SNC; enclosed is "proposed declaration for use in the subject application in response to the outstanding Office Action. I am meeting with Mr. Tanenholtz on the 23rd, and would like to have in my possession a copy which is generally approved by you"; attached is unsigned nine-page "DECLARATION UNDER RULE 132" with signature line for SNC and handwritten comments by SNC

Clipping of article, article, "Patent Office Withdraws Cohen-Boyer Plasmid Patent from Slated Issue, Rejects All Claims" by Gerry J. Elman, Genetics Engineering News, Vol. 2, September/October 1982, pp. 1,28-30.

Memo dated August 16, 1982 from Niels J. Reimers to Julius Krevans, Herbert Boyer, Lawrence Crowley, SNC and Roger Ditzel, in upper right date stamped "AUG 18 1982" and "file" handwritten by SNC; re lunch reservations at California Culinary Academy on October 22 at noon

August 11, 1982 issue of Campus Report, containing article, "Genetic engineering patent must await further scrutiny," by Deborah Franklin, pp. 7,8;"8/11/82" and "file please" handwritten by SNC at top of p. 7

Typewritten draft of four-page letter dated August 9, 1982 from SNC to Bert Rowland, cc to Niels Reimers re "Comments on U.S. Patent Office Action of August 2, 1982

Photocopies of three newspaper articles, stapled together: 1) "Stanford, UC rebuffed in bid for patent," by Karen Klinger, San Jose Mercury, August 6, 1982, pp. 3A,3B; 2) "Questions delay Stanford's genetic engineering patent," by Mary T. Fortney, August 5, 1982, pp. B-1,B-3; 3) "U.S. Turns Down Gene-Splicing Patent Bid," no byline, San Francisco Chronicle, August 6, 1982, p. 28.

Two-page draft of news article on letterhead of Stanford University Medical Center News Bureau with date "Aug. 5, 1982" at end, text contains handwritten spelling corrections (not in SNC's handwriting), the final version of this article appeared in Campus Report on August 11, 1982; handwritten at top "8/5/82" and "file" handwritten by SNC

Memo dated August 4, 1982 from Niels J. Reimers to Julius Krevans, Herbert Boyer, Lawrence Crowley, SNC and Roger Ditzel, in upper right date stamped "AUG 9 1982" and handwritten note by SNC, "Pat -- please put on calendar" note also asks about Inventor's Hall of Fame plaques, typed at bottom, "P.S. If you would like a ride to the City, please let me know. Niels"; memo text re lunch reservations at California Culinary Academy on October 22 at 1:00 p.m.

Letter dated August 2, 1982 from Stephen Budiansky, Washington Reporter to SNC, handwritten by SNC in upper right: "Patent file"; letter written on 5" X 8.5" notepaper with Nature America letterhead which is taped to a blank 8.5" X 11" sheet of paper; "I appreciated your phoning today with your comments on my article in last week's Nature. . . . If you would like to air the points you raised with me before the Nature audience, you are more than welcome to send us a note for the "Correspondence" section."; letter refers to article, "Key biotechnology patent delayed" by Stephen Budiansky, Nature, Vol. 298, July 29, 1982, pp. 409-410.

USPTO action cover sheet "DATE MAILED AUG 02 1982" from A.E. Tanenholtz to Bertram I. Rowland, in upper right of page "file" handwritten by SNC; Part I states that "Notice of References Cited by Examiner, PTO-892 is attached, Part II lists pending and rejected claims; two attachments: first a signed nine-page opinion by Alvin E. Tanenholtz, Primary Examiner, . . . "the prosecution is reopened to set forth objections and rejections necessitated by the discovery of 1) the Cohen et al, Journal of Bacteriology article, 2) the letter to Dr. Donald Fredrickson from Dr. Stanley N. Cohen, 3) the Nature article of April 3, 1980 and 4) to ascertain further information for basing a judgement on the availability of pSC101." and second a list of Other References by Examiner Tanenholtz

Two photocopies of article, "Key biotechnology patent delayed" by Stephen Budiansky, Nature, Vol. 298, July 29, 1982, pp. 409-410., one of which has some handwritten notes

Memo dated June 30, 1982 from Niels J. Reimers to Distribution: Donald Kennedy, William Massy Gerald Lieberman, Kent Peterson, Adrian Arima, Spyros Andreopoulos, Stanley Cohen, Roger Ditzel (UC), Herbert Boyer (UC); An article discussing various "uncertainties" regarding the validity of the Cohen/Boyer patent(s) will appear in the next issue of Biotechnology Newswatch, patent attorney notified by Patent Office that "product" application being withdrawn for further consideration

Memo dated June 22, 1982 from SNC to Niels Reimers, cc D. Purpura, D. Mendelow, K.J. Carpenter; "Subject: Patent Income"; "At a recent meeting of the Department of Genetics faculty concerns were raised about University policies regarding 1) timing of the crediting of patent income to departmental accounts, and 2) maintenance of a fixed "off-the-top" payment for the Office of Technology Licensing regardless of the amount or duration of patent royalties. . . . I am conveying these views to you in response to a departmental resolution that I do so."; "Kathy Roberts" handwritten at bottom of page

Letter dated March 18, 1982 from Evretechnika, Patent and Trademark Attorneys, Athens, Greece to SNC offering to file genetic engineering patent in Greece

Letter dated January 14, 1982 from SNC to Thomas D. Kiley, Genentech, Inc. re "Enclosed is a copy of the Cohen-Boyer patent signed by me."; two attachments: 1) Letter dated March 16, 1981 from Kiley to SNC, date stamped "APR 1 1981", asking SNC to autograph copy of patent already signed by Boyer, handwritten text of January 14, 1982 on front and back of this letter, 2) Unsigned photocopy of Patent 4,237,224, issued Dec. 2, 1980.

95 13
Cohen/Boyer patent information, 1983

Unsigned letter dated April 15, 1983 from Bertram I. Rowland to Niels J. Reimers, cc to Dr. Cohen and Dr. Boyer, text, "Enclosed for your information are copies of statements filed in the Patent Office by Helling and his attorney"; attached are two letters, 1) signed letter dated March 17, 1983 from James H. Dautremont, Intellectual Property Counsel, The University of Michigan to Honorable Commissioner of Patents and Trademarks; text describes letter from Robert B. Helling seeking to be named a joint inventor of SN959288; 2) signed and notarized letter dated March 16, 1983 from Robert B. Helling to Alvin E. Tanenholtz, Primary Examiner, USPTO, text states Helling's claims to be a joint inventor, notarized by Mike Dutzer on March 18, 1983, no attachments to Helling's letter

Signed letter from Peter Matlock to Stephen Jones, Austgen-Biojet, Re: S74, "Gene-splicing and S80-131, "Bioconversion Reactor", cc to P. McCarty, A. Bachmann, S. Cohen, K. Ku, in upper right date stamped "APR 22 1983" and handwritten by SNC, "Cohen-Boyer patent"; text includes, "If Austgen-Biojet is no longer interested in either of these technologies, then please inform us so that we may make alternate arrangements."

Signed letter dated April 19, 1983 from Bertram I. Rowland to SNC, "Enclosed is the latest revised declaration for your signature."; attached is six-page "DECLARATION" signed by SNC on April 20, 1983

Signed letter dated April 13, 1983 from Bertram I. Rowland to SNC and Boyer, "file" handwritten by SNC at top; text begins, "Enclosed for your review and comments are a draft of the proposed amendment in the subject case and copies of the three declarations that will accompany it."; attached unsigned six-page SNC Declaration has handwritten edits by SNC on pp. 1,5

Unsigned four-page David Hogness "DECLARATION UNDER RULE 132"; handwritten by SNC at top of first page, "where does he ___ Adv each of ____ to practice"

Unsigned six-page SNC "DECLARATION"

Unsigned four-page Boyer "DECLARATION"

Unsigned 32-page "AMENDMENT" with signature line for Bertram I. Rowland; paper clipped behind it is unsigned six-page SNC "DECLARATION"; both documents have handwritten edits by SNC

Signed letter dated March 4, 1983 from Katharine Ku to David Milligan, Abbott Laboratories; text contains summary by Ku for licensees of recently received Patent Office Action "on the pending "product" patent application"; in upper right, "Cohen" handwritten, date stamp, "MAR 07 1983", and "Cohen-Boyer patent file" handwritten by SNC

Signed three-page letter dated March 9, 1983 from SNC to Bertram Rowland, "The following is my response to the questions raised by Mr. Rannenholz [sic] in the U.S. Patent Office Action as of January 21, 1983."; no attachments

Signed letter dated February 28, 1983 from Katharine Ku to Jack Feather, The Cambridge Plan; in upper right "S. Cohen" handwritten, and in SNC's handwriting, "Cohen-Boyer patent file"; text begins, "We would like to acknowledge receipt of Cambridge Plan's letter of intent to terminate the License Agreement governing patent rights under U.S. patent No. 4,237,224."

Unsigned form letter template from Katharine Ku to "[Adr]", "chron" handwritten at top right, "FEB 25 1983" date stamped, post-it attached with "Cohen-Boyer Patent file" handwritten by SNC, stapled to front of letter is small note signed Kathy Ku, "2/23/83 Prof. Cohen: Thought you might like to see this royalty calculation form. So far, 54 licensees have paid . . ."; text of form letter begins, "Enclosed is a one-page reporting form for calculating royalties for 1982. . . . Since this is the first use of this reporting form, we would appreciate your reviewing it carefully."; attached are two copies of the yellow one-page form, "Determination of Royalties (Recombinant DNA License" for Calendar Year 1982, form #TL-101

USPTO cover sheet form mailed January 21, 1983, responsive to communication filed on "Nov. 1 and 4 1982": Part I: "Notice of References Cited by Examiner, PTO-892", "Notice of Art Cited by Applicant, PTO-1449, and "Interview summary with Mr. Deutremont [sic] and copy of letter to Robert B. Helling" and Part II lists claims pending and rejected; stapled to the front of cover sheet is large post-it with handwriting "From: Bert Rowland For: Dr. Stanley Cohen 1-24-83" crossed out and in SNC's handwriting, "Patent file", date stamped "JAN 25 1983"; stapled behind cover sheet are six documents listed in the rows below

First document stapled behind cover sheet is a 12-page opinion with stamp at end, "ALVIN E. TANENHOLTZ PRIMARY EXAMINER ART UNIT 172"

Second document stapled behind cover sheet is undated, unsigned letter on USPTO stationery from Alvin E. Tanenholtz to Robert B. Helling, cc to James H. Deutremont [sic] and Bertram R. [sic] Rowland, letter has three paragraphs of questions for Helling

Third document stapled behind cover sheet is Examiner Interview Summary Record regarding phone interview of Bert Rowland on November 16, 1982, signed by Alvin E. Tanenholtz, re Helling inventorship claim, also "Told him I am still weighing the impact of the Hogness possession of pSC101 prior to statutory bar date."

Fourth document stapled behind cover sheet is a one-page summary of "Telephone Call to Alvin E. Tanenholtz from James H. Deutremont [sic] on November 23, 1982 regarding SN 959,288"

Fifth document stapled behind cover sheet is a Notice of References Cited, listing Wensick et al., 1974 and signed "Tanenholtz 1/20/83"

Sixth and last document stapled behind cover sheet is a List of Prior Art Cited by Applicant listing Lederberg, J., Toward Century 21: Technology, Society, and Human Values, pp. 39-52, 1970

Signed letter dated January 17, 1983 from Katharine Ku to David Milligan, Abbott Laboratories, "Prof. Cohen" and "cohn/Boyer" [sic] handwritten at top, date stamped "JAN 20 1983"; 1983 annual royalties due by February 1" and FYI, " . . . We have not yet received any official action from the Patent Office to our November 1, 1982 response for the DNA "product" patent application."

95 14
Cohen/Boyer patent information, 1983

Handwritten "MEMO TO THE FILE" dated 12/21/83 from K2 to S74-43, cc to S. Cohen, UC re DNA Cloning; in upper right date stamped "DEC 27 1983" and "file" written by SNC; text: "Per Bert: "Formal matters re BR will be resolved early Jan -- Will likely receive Notice of Allowance in Feb Will possibly/probably get issued patent in March"

Four sheets of paper stapled together: 1) Unsigned letter from Katharine Ku to Daniel P. Weingarten, GIBCO Laboratories, Life Technologies, Inc., in upper right "S. Cohen" handwritten, stamped "DEC 29 1983" and "file" written by SNC; text: "We were surprised and puzzled by your letter of December 16. . . . All the current issues surrounding the pending patent application have been resolved."; 2) Signed letter dated December 16, 1983 from Weingarten to Neils [sic] Reimers, cc to M.J. Barrett, Ph.D. and K.E. Blackman, Ph.D.; in upper right, date stamped "DEC 29 1983" and below that stamped 'STANFORD UNIVERSITY DEC 20 1983 TECHNOLOGY LICENSING"; "I have spoken to Dr. Barrett about some of the issues you raised in our meeting in early October regarding the Cohen-Boyer patent. dr. Barrett called to my attention a letter he wrote to you dated January 7, 1983, which pointed out several significant errors in the submission by the authors under rule 131." asks if issues resolved; 3) Unsigned letter dated June 17, 1983 from Katharine Ku to James Barrett, President, Bethesda Research Laboratories, "file" written in top right, " . . . I had wanted to have the opportunity to respond in person to your letter of June 7, 1983, regarding the DNA cloning patent. The attorney handling the prosecution brought the information you presented forward to the Patent Office. It is now part of the record. For your information, I have excerpted the relevant portion from the recent response."; 4) Photocopy of 14 lines of printed text, handwritten in upper right is "Excerpt from Response to Jan 21, 1983 Office Action", text, "It is noted that consideration of the declaration under Rule 131 has been held in abeyance. . . . The error has to do with referring to pSC101, where the results which are reported refer to pSC105. However, once the issue concerning Professor Helling's inventorship is resolved, the declaration becomes moot, since the articles coauthored by Professor Helling would no longer be relevant. . . ."

Two stapled stacks of paper that have been paper-clipped together: 1) Legal documents: log sheet identical to one in second stack, except that this sheet has one newer activity, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, "Amendment / Petition to make special" Official Date and Forwarded to Client 9-20-83, in upper right stamped "STANFORD UNIVERSITY SEP 22 1983 TECHNOLOGY LICENSING", handwritten "Roger Stanley", date stamped "SEP 28 1983" and handwritten by SNC: "file Cohen-Boyer patent"; attached are two USPTO Forms, both signed by Bertram I. Rowland on September 20, 1983: five-page AMENDMENT "Cancel Claims 18, 20-22, 24-28, 30-37, 64, 77, 78, and 80-87, without prejudice to their renewal and in light of the following claims." then adds Claims 88-98; also attached is two-page PETITION TO MAKE SPECIAL 37 CRF [sic] �1.102, " . . .to make the application special, to allow for early issuance. As the Commission is aware, this application has assumed extreme public interest. . . . Furthermore, a number of novel issues were raised during the prosecution, which issues may help other patent counsel to evaluate patentable subject matter in the rapidly growing field of recombinant DNA technology. Also, this application was previously allowed, and allowance withdrawn at the last moment."

Two stapled stacks of paper that have been paper-clipped together: 2) second stapled stack of paper has cover sheet identical to the one mentioned above, except that there is one fewer line on the log sheet; newest item is "Office Action", Official Date 9-30-83, Forwarded to Client 9-16-83; stapled to log sheet is USPTO Form responsive to communication filed on 4/28/83 and 7/5/83, "Notice of References Cited by Examiner, PTO-892" and "Examiner Interview Summary Record"; lists pending, cancelled, allowed, and rejected claims, with four pages of details, list of references: Lobban thesis, 1972 and Hogness, 1975

Photocopy of article, "New Technique to Produce Proteins May Alter Biotechnology Industry," by Jerry E. Bishop, Wall Street Journal, November 10, 1983, page unknown; at top of page, handwritten {looks like Ku's handwriting}: "- not plasmid - no replication system - DNA doesn't replicate", and "11/2/83 Stanley: Niels said you'd like copy of this -- sounds fishy, eh? Kathy", date stamped "DEC 6 1983", "Cohen-Boyer patent file" handwritten by SNC; article describes new technique by Fred Russell Kramer of Columbia

Unsigned, undated form letter from Katharine Ku to DNA Licensees; handwritten at top; "Subject: License Agreement Between [1] and Stanford University Covering U.S. Patent No. 4,237,224 By Stanley N. Cohen and Herbert Boyer"; letter begins, "We wish to bring you up to date with respect to the prosecution of Patent Application Serial No. 959,288, the "product" application relating to the DNA cloning methods described in the U.S. patent indicated above. The Patent Office has notified us that the claims which cover recombinant plasmids and other vectors able to replicate in prokaryotic host organisms are allowable."; text also includes, "In a continuation application, we will continue prosecution with the Patent Office of claims with respect to yeast and other eukaryotic unicellular organisms as hosts. . . . An attachment lists the claims of the application that have been deemed allowable."; attached are unsigned letter dated December 12, 1983 with handwritten edits and writing at top of page, "Stanley - Please make the appropriate changes ASAP. Thanks. -- K." and written in SNC's handwriting, "Cohen/Boyer patent file" and two-page document listing Claims 88-98

Letter dated November 18, 1983 under letterhead of "Law Offices of Wegner & Bretschneider" in Washington, DC, which closes "Respectfully submitted, HAROLD C. WEGNER, PETITIONER by Ronald R. Snider Reg. No. 24,962 (signed by Snider)" to "Hon. Commissioner of Patents and Trademarks" requesting immediate decision re having patent file opened; attached are 1) memo dated September 14, 1983 from Linda S. Paine to Harold C. Wegner, "In summary, Mr. Tarring of the PTO Solicitor's Office had no firm idea of when he would review the Petition, but indicated that the status should be checked again in October." and 2) a page from 37 CFR [sic] �1.114 with underlining of "If there is no objection the petitioner is permitted to see the entire parent application"

Legal documents: log sheet, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, newest item is "Notice of Allowability", Official Date 10-11-83 and Forwarded to Client 10-18-83, in upper right stamped "STANFORD UNIVERSITY OCT 19 1983 TECHNOLOGY LICENSING", handwritten "cc: S. Cohen T. Crotte", date stamped "OCT 21 1983" and handwritten by SNC: "file"; attached are USPTO Form signed by primary examiner Alvin E. Tanenholtz allowing Claims 88-98, a one-page "Examiner's Amendment to the record" and "Examiner Interview Summary record that interview occurred 10/6/83 of Bert Rowland by Al Tanenholtz

Legal documents: log sheet, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, newest item is "Decision on Petition filed 9/21/83", Official Date 9-30-83 and Forwarded to Client 10-19-83, in upper right stamped "STANFORD UNIVERSITY OCT 20 1983 TECHNOLOGY LICENSING", handwritten "cc: S. Cohen", date stamped "OCT 26 1983" and handwritten by SNC: "file"; attached "Decision on Petition Filed September 21, 1983", mailed September 30, 1983, signed by Robert F. White of USPTO, "applicants' petition is hereby granted", Rowland's name and address typed at bottom of page

Signed letter dated March 17, 1983 from James H. Dautremont, Intellectual Property Counsel, The University of Michigan to Honorable Commissioner of Patents and Trademarks, front page has large red "CONFIDENTIAL" stamp; text describes letter from Robert B. Helling seeking to be named a joint inventor of SN959288; attached signed and notarized letter dated March 16, 1983 from Robert B. Helling to Alvin E. Tanenholtz, Primary Examiner, USPTO, front page has large red "CONFIDENTIAL" stamp, text states Helling's claims to be a joint inventor, notarized by Mike Dutzer on March 18, 1983, no attachments to Helling's letter

Legal documents: log sheet, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, newest item is "Office Action", Official Date 8-30-83 and Forwarded to Client 9-69-83, in upper right stamped "STANFORD UNIVERSITY SEP 20 1983 TECHNOLOGY LICENSING", date stamped SEP 22 1983" and handwritten by SNC: "File Cohen-Boyer patent"; attached USPTO Form responsive to communication filed on 4/28/83 and 7/5/83, "Notice of References Cited by Examiner, PTO-892" and "Examiner Interview Summary Record"; lists pending, cancelled, allowed, and rejected claims, with five pages of details, list of references: Lobban thesis, 1972 and Hogness, 1975

Signed letter dated September 7, 1983 from SNC to Bertram I. Rowland, "Enclosed is a reprint of my 1975 paper describing the co-transformation procedure claimed in the Columbia University patent. I think you will agree that the paper is pretty explicit in anticipating what Science and Nature report as Columbia's claims."; no enclosure

Unsigned 10-page letter under letterhead of "Law Offices of Wegner & Bretschneider" in Washington, DC from "Harold C. Wegner Reg. No. 25,258" to Honorable Commissioner of Patents and Trademarks, Attn: Solicitor (Henry Tarring, Esq.; Katharine Ku's business card stapled to top of first page and handwritten "Stanley Cohen", on top right of first page date stamped "AUG 29 1983" and handwritten by SNC "Cohen-Boyer patent"; letter text begins, "This is a request under 37 CFR �1.14(e)(2) for access to United States patent application Serial No. 959,288"

Signed letter dated August 4, 1983 from Katharine Ku to Daniel P. Weingarten, GIBCO Division, The Dexter Corporation, "Re: Stanford Docket S74-43, "DNA Cloning"" and "Stanford Docket S82-64, "DNA Hybridization Probes"; offers GIBCO/Dexter "a license to the Cohen/Boyer DNA cloning invention; particularly since Dexter recently acquired Bethesda Research Laboratories, we feel that BRL's and/or Dexter's activities no doubt involve recombinant DNA."

Signed letter from Katharine Ku to Brian McCarthy, California Biotechnology Inc., cc: J. Newman, M. Petit, S. Falkow, T. Merigan, F. Murad; in upper right, "S. Cohen" handwritten, date stamped "AUG 9 1983" and handwritten by SNC, "Cohen/Boyer patent"; text, "Stanford has many technologies which CBI may be interested in licensing," including "Stanford Docket S82-64, "DNA Hybridization Probes"; no attachment

Photocopy of a page from New Scientist, June 30, 1983 with article, "Decision due in billion-dollar patent row," by Barry Fox; stapled to front is small handwritten note, "7/11/83 Stanley: In case you haven't seen -- this article is just trying to sensationalize a non-issue (Ziff). Kathy", note date-stamped "JUL 14 1983" and handwritten by SNC, "Cohen/Boyer patent file"; article begins, "The US Patent Office will decide sometime in the coming month whether a short article, published in New Scientist 10 years ago, invalidates potentially the most valuable patent application ever filed."

Unsigned two-page form letter from Katharine Ku to "[Adr]" ; "Re: License Agreement covering Cohen/Boyer DNA Cloning Invention; U.S. Patent No. 4,237,224 and Application Serial No. 959,288; handwritten at top, "5/19 Stanley -- Is this acceptable? Please let me know if you have changes -- Kathy"; in SNC's handwriting, "not satisfactory -- file I have spoken with Kathy Ku" and handwritten comments by SNC and Ku; text begins, "We have recently submitted Stanford's Response to the present Office Action on pending patent application serial No. 959,288. The main points of the Office Action and the Response are summarized below"

Binder clip holding four documents. First document is 33-page "AMENDMENT" signed by Bertram I. Rowland on April 27, 1983

Binder clip holding numerous documents. Second document is six-page "DECLARATION" signed by SNC on April 20, 1983; attached are SNC articles, "The Stanford DNA Cloning Patent", 1982; "The manipulation of genes," 1975; "The transplantation and manipulation of genes in microorganisms," 1980;

Binder clip holding numerous documents. Third document is four-page "DECLARATION" signed by Herbert W. Boyer on April 19, 1983

Binder clip holding numerous documents. Fourth document is four-page "DECLARATION UNDER RULE 132" signed by David S. Hogness on April 26, 1983.

95 15
Cohen/Boyer patent information, 1984

News release dated August 28, 1984 from Stanford University Medical Center News Bureau, "Cohen-Boyer Genetic Engineering Products Patent Issues" News Bureau contact Laura Hofstadter; handwritten note stapled to first page "8/31/84 Stan: In case you didn't get this--Congratulations! Kathy"; post-it attached to first page, "file - Cohen/Boyer patent" handwritten by SNC

Letter dated December 31, 1984 from Katharine Ku to Mr. Lewin, Agricultural Genetics Co., Ltd. "Re: Stanford Docket S74-043, "DNA Cloning", "We are very pleased that Agricultural Genetics has decided to become a licensee"

Letter dated December 13, 1984 from Katharine Ku to Albert P. Halluin, Cetus Corporation "Re: Stanford Docket S74-043, "DNA Cloning"; "In response to your letter of December 3, 1984, the pending patent application claiming recombinant plasmids in unicellular eukaryotic hosts are covered by the original License Agreement. . . . The post-termination responsibilities of a licensee are detailed in Paragraph 8.6 of the License Agreement; no other residual rights or obligations rest with the licensee, including credits."; December 3, 1984 letter is attached

Clipping of article, "Cohen-Boyer Plasmid Patent: An Analysis of the Issues" by Bruni Kobbe, Genetic Engineering News, November/December 1984, pp. 3,11; post-it attached to first page, "Cohen/Boyer patent file" handwritten by SNC

Letter dated November 15, 1984 from Katharine Ku to Roger Ditzel, Patent, Trademark & Copyright Office, University of California, cc H. Boyer and SNC; "Re: Stanford Docket S74-043, "DNA Cloning", "this letter serves as the annual report setting forth the status of patent prosecution, commercial development, and licensing activity for the fiscal year ended August 31, 1984"

Letter dated December 31, 1984 from Katharine Ku to Donald Perella, Merck & Co, Inc. "Re: Stanford Docket S74-043, "DNA Cloning", "We are very pleased that Merck intends to become a licensee"

Letter dated December 31, 1984 from Katharine Ku to James Barrett, Bethesda Research Laboratories, Inc. "Re: Stanford Docket S74-043, "DNA Cloning", "We are very pleased that BRL/Life Technologies intends to become a licensee"

Photocopy of article "Cohen-Boyer Patent Finally Issued", by Colin Norman, Science, September 14, 1984, p. 1134.

Genetics Technology News, Vol. 4, No. 10, October 1984; "Second Cohen-Boyer Patent Issues", p. 1, no byline, five paragraphs; patent name, number an issue date listed in "Patents" section on p. 11

Photocopy of New Scientist, September 6, 1984, p. 7, containing article, "Gene patent granted: now the real fight begins", by Ian Anderson; "Millions of dollars are at stake, not to mention the future organisation of the genetic engineering industry."

Memo dated May 18, 1984 from Niels J. Reimers to "P. Berg, S. Cohen, A. Kornberg, J. Lieberman, D. Purpura, and I. Weissman", "SUBJECT: "Limits in the Handling of Genetic Engineering"; met with Wolf-Michael Catenhusen, of German Bundestag, involved with "special Bundestag committee set up to deal with "problems relating to new biotechniques." I thought you would be interested in the preliminary report of his committee . . . . Rather than leave the field to Jeremy Rifkin by default, a position paper by those involved in the field, perhaps along the line of Mr. Catenhusen's report, might be worth considering."; attached report (in English)

Letter dated May 16, 1984 from Dorothy Hinden, NIAID to SNC and Fred A. Gustafson, Stanford Sponsored Projects Office; "Frank E. Robbins, Law Office of Robbins and Laramie, Washington, D.C., has requested a copy of your successful grant applications and progress reports from 1969 to 1976 for R01-AI08619 to be used by Mr. Robbins in an evaluation of United States Patent 4,237,224 . . . Please advise us of any portions of your proposal that you believe should be withheld under the exemptions provided by the [Freedom of Information] Act." attached two-page printout "FOIA EXEMPTIONS USUALLY APPLICABLE TO GRANT INFORMATION"

Published copy of Patent 4,468,464, Date of Patent: August 28, 1984

Photocopy of article, "A patent on everything", no byline, The Economist, September 8, 1984, pp. 72,75. "The latest--and so far two most important--patents are so broad that other companies could be shut out of the industry unless they license the technology or take on an expensive legal fight."

Form letter template from Katharine Ku containing handwritten date "9/6/84" and handwritten note "9/6/84 Stan: If you're interested in the list of companies we are contacting, here 'tis. K" letter text says Patent 4,468,464 issued on August 28, 1984; "We understand that ___ has been using the basic technology of recombinant DNA in your research and development.", invites them to become licensees; attached to letter is 29-page "DNA Form Letter A Address List"

Issue of Science News, Vol. 126, September 8, 1984; stapled to front is note from editor Joel Greenberg, "You may be interested in the article on page 150 Any comments would be welcome."; attached to note is post-it with "Cohen/Boyer patent file" handwritten by SNC; article "Gene engineering: Patent for products" by J. A. Miller on p. 150

Two copies of Patent 4,468,464, with attached handwritten note referring to three copies, "9/4/84 Stan: Here are 3 copies for your file. I'm so excited that we got the hard copies -- Kathy"

Draft of news release from Stanford University Medical Center News Bureau, on first page of draft "Cohen/Boyer patent file" handwritten by SNC; "Cohen-Boyer Genetic Engineering Products Patent Issues", News Bureau contact Laura Hofstadter; small note attached to first page, "8-28-84 To Stan Cohen From Laura Hofstadter Draft attached of news release final version"

Draft of news release from Stanford University Medical Center News Bureau about newly issued Patent; small note attached to first page, "7-27-84 To Stan Cohen From Laura Hofstadter The latest version" with "file" handwritten by SNC; news release begins, "A patent covering genetically engineered molecules that can be used to generate biological products was issued today (Aug. 7)"; patent was issued August 28, 1984

Draft of news release from Stanford University Medical Center News Bureau about newly issued Patent; small note attached to first page, "July 19, 1984 To Stan Cohen From Laura Hofstadter This draft incorporates the changes you suggested. My notes from a discussion with Bert Rowland indicate that the patent does state plasmid explicitly, though he thinks it means any circular piece of DNA with a replication system and a structural gene from a source that doesn't normally exchange information with the host that recognizes that replication system. Would this mean viral vectors are included? L"; draft contains numerous handwritten comments by SNC

Draft of news release from Stanford University Medical Center News Bureau about newly issued Patent; letter clipped to front of draft: dated July 18, 1984 from Katharine Ku to Frank Adams, UOP, Inc., states minimum annual advance for 1984 not yet received, "this letter serves as written notice of termination to UOP by Stanford, effective October 15, 1984"; small note clipped to front of letter refers to the news release draft behind the letter; note reads, "July 17, 1984 To Stan Cohen From Laura Hofstadter In anticipation of news interest when the new patent is issued, I've drafted this news release. Niels, Kathy and Bert have already seen it. Please let me know if you find any factual errors--Thanks"

Letter dated June 27, 1984 from Katharine Ku to John Chester, National Science Foundation, at upper right of letter "File Cohen/Boyer patent" handwritten by SNC; "Thank you for your call in April, informing us of the request by Robbins and Laramie for information under FOIA . . . . As we discussed, there does not seem to be anything in the file that would be confidential. For your information, we expect the product patent to issue August 7 with U.S. Patent No. 4,464,473."; handwritten note at bottom of letter, "7/6/84 Stan: Niels said you were concerned about this letter. Chester reassured us that he would keep the information confidential. I'm sorry that I told him (in light of your reaction) but since NSF is a "sponsor", I had thought it was appropriate. I shall keep quiet till Aug 7! K."

Letter dated June 27, 1984 from Katharine Ku to John Chester, National Science Foundation, handwritten note in upper right, "Stanley Cohen FYI -- K2 " and "Cohen/Boyer patent file" handwritten by SNC; "Thank you for your call in April, informing us of the request by Robbins and Laramie for information under FOIA . . . . As we discussed, there does not seem to be anything in the file that would be confidential. For your information, we expect the product patent to issue August 7 with U.S. Patent No. 4,464,473."

Photocopy of "Gene Splicers Square Off in Patent Courts" by Jeffrey L. Fox, Science, Vol. 224: 584-586.; in upper left of page one "Cohen/Boyer patent file" handwritten by SNC

Legal documents: log sheet for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, notice of Allowance and Request for Expedition, Official Date and Forwarded to Client 4-18-84; attached two-page USPTO Form, "Notice of Allowance and Issue Fee Due", addressed to Bertram I. Rowland, Issue Fee Due July 5, 1984, SC/Serial No. 05/959,288, Fee Due: $500.00; behind form is one-page "REQUEST FOR EXPEDITION", "for the following reasons: 1. This application has been made special due to its early filing date and its national importance; and 2. there have been numerous requests for public access to the file wrapper.", signed by Bertram I. Rowland on April 18, 1984

DECISION REFUSING REJECTION UNDER 37 CFR STAMPED, "COPY MAILED MAR 29 1984 COMMISSIONER'S OFFICE" Re Serial No. 05/959,288, "Dr. Helling's Assertion of Inventorship" and "The Inaccuracy Regarding The Method For Preparing Plasmid pSC101"; signed by Alfred L. Leavitt, Special Program Examiner and initialed by Conferee M.A. Antonakas

Handwritten note, "3/21/84 Bert says it's still in Leavitt's group ? to Tanenholtz by End of Month -- means we hope to get Notice of Allowance in May and will maybe issue in July or August. Sigh. K"

Letter dated March 15, 1984 from Roger G. Ditzel, Director of Patent, Trademark and Copyright Office at University of California to Katharine Ku, cc to SNC and Herbert W. Boyer; re Amendment No. 1 to Agreement Concerning Administration of Rights in Invention is enclosed. "The effective date of this Amendment is March 1, 1984."; no attachment

Letter dated March 14, 1984 from Katharine Ku to Albert P. Halluin, Cetus Corporation; refers to Halluin letter of February 27, "You expressed concerns about the validity/enforceability and scope of the claims of U.S. Serial No. 959,288."; attached are February 27, 1984 letter from Halluin to Ku and three drafts of a response from Ku, each draft with a note to SNC asking for his feedback

Letter dated March 7, 1984 from Katharine Ku to Roger Ditzel, "Re: Stanford Docket S74-43, "DNA Cloning", re Amendment No. 1 to Agreement Concerning Administration of Rights in Invention enclosed for UC signature; Amendment attached

Memo dated February 1, 1984 from Nancy Holt to Bert Rowland, "Enclosed is the signed declaration of Stan Cohen regarding" Biologically Functional Molecular Chimeras; attached to memo are signed letter dated January 30, 1984 from Bertram Rowland to SNC, "Enclosed for your signature is a ribbon copy of your declaration, revised in accordance with your changes of January 27, 1984." and three-page "DECLARATION OF STANLEY N. COHEN" re pSC101 signed by SNC on February 1, 1984

Binder clip holding numerous documents. First is memo dated January 27, 1984 from Nancy Holt to Bert Rowland, "Enclosed is the declaration for BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS as Stan Cohen has edited it; attached are two drafts of first two pages of declaration, one with extensive handwritten edits by SNC; after memo is letter dated January 25, 1984 from Bertram I. Rowland to SNC and Herbert Boyer, "Enclosed for your review and comments is the proposed response to be filed in the subject application." with three attachments, all of which are unsigned: 1) p. 3 of SNC Declaration (pp. 1-2 probably pages with handwritten edits), 2) two-page Boyer Declaration, 3) and 10-page "RESPONSE TO REQUIREMENT FOR INFORMATION" which begins, "In response to the Requirement for Information of January 6, 1984" and ends with signature line for Rowland. Letter dated December 16, 1977 from Bertram I. Rowland to Niels Reimers, cc SNC, recapping Rowland's interview with patent examiner Alvin E. Tanenholtz, ". . . while he was willing to allow claims which describe a basic method for producing transformants, he was not willing to allow any of the other claims" and mentions new work that questions whether pSC101 was the vector, "As to this matter as well as other matters, consideration should be given whether we should revise the application before refiling it as to the plasmid claims." Unsigned copies, with no attachments, of a January 20, 1975 form letter from Rowland to each of the following: Robert B. Helling, John F. Morrow, Annie C.Y. Chang, Charles Yanofsky, Howard M. Goodman, Vickers Hershfield, Michael A. Lovett, Donald R. Helinski, re "Pat. appln. for PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS - S. Cohen and H. Boyer . . . . You are a co-author and, therefore, I am requesting your cooperation in signing the accompanying disclaimer, disclaiming being a co-inventor." Unsigned copies of a January 28, 1975 form letter from Rowland to each of the following: Robert B. Helling, Annie C.Y. Chang, Charles Yanofsky, Howard M. Goodman, Vickers Hershfield, Donald R. Helinski, Michael A. Lovett, and John F. Morrow, each letter has a cc to SNC and Boyer, re "Pat. appln. for PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS - S. Cohen and H. Boyer"; "My prior letter has apparently been subject to an unintended misunderstanding. . . . In using the term "on behalf of" I intended that Professors Cohen and Boyer were the inventors, but did not intend that I was employed by them. The request for a patent application was initiated by Stanford University and the University of California who are the assignees and have the financial interest in the patent application. As I am sure you are well aware, the Universities are sorely stressed for funds and the patenting of research developments which have commercial potential is becoming an avenue for obtaining additional funds. In recognition of the needs of the University, when the research is funded by governmental agencies, the government normally allows the Universities to license patents covering government-sponsored research and receive the funds. . . . The issuance of the subject patent will in no wise inhibit any researcher, either academic or commercial, from carrying out additional research in the areas covered by the patent. Should a development be commercialized and come within the ambit of the subject patent, Stanford and UC would have the opportunity to receive royalties from such commercial use. I am enclosing a copy of the letter sent to me by Stan Cohen explaining his understanding of the purpose and intent of the Universities in filing the subject patent application. I would also like to add that prior to becoming a patent attorney, I received my doctorate in organic chemistry and was employed as a research chemist. I am personally sensitive to the interest and the needs of the academic community and am appreciative of their concerns."

95 16
Cohen/Boyer patent information, 1985

SECOND PRELIMINARY AMENDMENT re "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", 24 pp., signature line on p. 24 is unsigned; text has handwritten comments by SNC

Memo dated November 8, 1985 from SNC to Kathy Ku; "Enclosed is a recent advertisement from Promega Biotech . . . I would imagine that this product falls under the Stanford patent, along with some of their other products--notwithstanding their claims to the contrary."; Attached photocopy of one-page ad for "ProtoBlotTM Immunoscreening System"

Two-page news release dated April 15, 1985 from Stanford University Medical Center News Bureau, on first page "4/21 Stan FYI - K2" handwritten in upper right, also "Cohen/Boyer file" handwritten by SNC; title: "11 Companies Sign on While Four Terminate Licensing Agreement with Stanford", News Bureau contact Laura Hofstadter; release ends, "Following is a list of the licensees as of April 12, 1985", with list of 73 companies

Letter dated November 1, 1985 from Katharine Ku to Irving Feit, Ciba-Geigy; "We are most pleased that Ciba-Geigy has decided to take the Cohen/Boyer DNA Cloning license . . . . As I mentioned, we are in the process of reevaluating the royalty structure of the Agreement so that this offer expires December 10, 1985."

Letter dated October 17, 1985 from Katharine Ku to Robert D. Weist, Applied Molecular Genetics, Inc.; Stanford awaiting signed copies of licensing agreement, "As you know, it is important for AmGen to be a licensee, particularly in light of AmGen's sales and advertising of recombinant DNA products and inquiries by other licensees. Adrian Arima, Stanford legal counsel, and I would like to discuss the issues with AmGen representatives to answer any questions of patent scope and interpretation of the license."

Letter dated December 14, 1984 from Thomas A. Mann, United States Biochemical Corp. to Katharine Ku; re license agreement, ". . . we would be very happy to meet with you to discuss the possible applicability of this patent to any of our activities."; three attachments: 1) handwritten notes "12/17 FG - Do we have info? K" and "9/5 Stan: FYI - I'll follow-up on this."; clipped to letter is OTL memo to file dated 9/6/85 by K Ku re "Telecon c Joe Sorge, Vector is behind schedule re recombinant "construction", in about 4-5 months, they'll be making/developing products and will take a C/B license then", note to SNC, "Stan - As long as Vector is going to take a license, it's probably not economically-wise to press them now. K"; 2) letter dated September 1, 1985 from James C. Gaither, Center for Biotechnology Research to Niels Reimers, OTL re "License Agreements between Stanford University and the Center for Biotechnology Research - Stanford Docket Nos. S81-78 and S81-79", "no significant progress has been made toward commercial use of products in the past year"; 3) cover letter dated August 26, 1985 from James C. Gaither to Niels Reimers re Stanford Docket No. S80-23 with "Quarterly Report Quarter Ended June 30, 1985" re licensed products and sublicenses: none of either

Letter dated September 3, 1985 from Katharine Ku to Albert P. Halluin, Esq., Cetus Corporation, "Stan Cohen FYI - K" handwritten in upper right, also "Cohen/Boyer patent file" handwritten by SNC; text: " . . . We have agreed to the following policy effective September 3, 1985 for Cetus/Stanford so-assigned inventions," with details; unsigned AGREED AND ACCEPTED signature line for Cetus; attached are letters both dated August 30, 1985 from Katharine Ku to Daniel R. Henderson, Microgenics Corp., and Frederic de Hoffman, Salk Institute Biotechnology/Industrial Associates, Inc. (SIBLA) inviting them to become Cohen/Boyer patent licensees; Microgenics letter: "Microgenics must be pleased to have the distinction of being the first company to receive FDA approval for a recombinant DNA clinical test."; SIBLA letter: "We wrote last year to offer SIBLA a license to the Cohen/Boyer patents but received no response."

News release dated August 23, 1985 from Stanford University Medical Center News Bureau, "Cetus Corp. Resumes Genetic Engineering License Agreement with Stanford" News Bureau contact Laura Hofstadter; Attn: Neils [sic] Reimers and Kathy Ku, handwritten "To: Stan Cohen" in upper right; Reimers quoted in story, "In effect, the license will continue exactly as before, as if there had been no termination," release also states, "Stanford agreed to reinstate the $250,000 in credits the company had earned.", now 74 licensees, "Over $3.5 million have been received since the licensing program was initiated in 1981."

Letter dated April 26, 1985 from Julius R. Krevans, M.D., Chancellor of UCSF to President Donald Kennedy of Stanford thanks for arranging luncheon to honor Boyer and Cohn [sic], handwritten note at bottom, "Stan - In case you didn't receive a copy, here 'tis. Kathy"

Letter dated April 23, 1985 from Niels Reimers to SNC; "By signature below, you agree to return upon our written request, to Stanford, the original of U.S. Patent No. 4,237,224, issued December 2, 1980. If it does become necessary to request the patent, be assured our intent will be to return it to your possession as soon as it is not needed."; AGREED AND ACCEPTED signed by SNC April 27, 1985

Letter dated November 29, 1984 from Katharine Ku to Allen W. Richmond, Phillips Research Center, "bcc: S. Cohen" handwritten in upper right, also "file - Cohen/Boyer patent" handwritten by SNC; "Re: Stanford Docket S74-43, "DNA Cloning"; "We are most pleased to return one fully executed copy of the License Agreement covering the above referenced invention. . . . Again, both Stanford and the University of California are delighted to have Phillips on board"; no attachment

Letter dated January 2, 1985 from Katharine Ku to Al. A. Jecminek, Triton Biosciences Inc., handwritten in upper right "Dr. Stan Cohen FYI, Kathy Happy New Year"; "Re: Stanford Docket S74-43, "DNA Cloning"; "We are pleased to return a fully executed copy of the License Agreement covering the Cohen/Boyer patents."; attached are three letters all dated January 2, 1985 from Katharine Ku: 1) to I.V. Karau, BASF Aktiengesellschaft, 2) to Herbert L. Heyneker, Genendor, Inc., and 3) to John H. Newman, California Biotechnology, Inc.; each letter expresses delight the company has become a Cohen/Boyer patent licensee

Letter dated January 4, 1985 from Katharine Ku to Nan Newell, Calgene, Inc. S. Cohen", handwritten in upper right, also "file" handwritten by SNC; Stanford Docket S74-43, "DNA Cloning", "We are pleased that Calgene has decided to become a licensee of the Cohen-Boyer patents. . . . Niels Reimers, our director, was agreeable to Calgene having the benefit of the 1984 offer since we have not yet announced our new terms."; "no attachments

Letter dated March 15, 1985 from Katharine Ku to Ed Pandolfino, Becton Dickinson Immunocytometry Systems, "Stan Cohen FYI - K2" handwritten in upper right, also "file" handwritten by SNC; "Re: Stanford Docket S74-043, "DNA Cloning", "Enclosed for your files is a fully executed copy of the License Agreement covering the Cohen-Boyer patents."; no attachments

Confidential memo dated March 14, 1985 from Kathy Ku "To: Stanford Docket File S74-043, "DNA Cloning", "SUBJECT: Meeting with Cetus on March 5, 1985" re termination of the Cohen/Boyer license

Letter dated March 14, 1985 from Katharine Ku to Albert P. Halluin, Cetus Corporation "to confirm our understanding of Cetus's reasons for terminating the License Agreement"

Letter dated February 13, 1985 from Katharine Ku to R. G. Schweikhardt, ZymoGenetics "Re: Stanford Docket S74-043, "DNA Cloning", "delighted to have ZymoGenetics as a licensee"

Letter dated February 14, 1985 from Katharine Ku to Richard W. Armentrout, Syntro Corporation "Re: Stanford Docket S74-043, "DNA Cloning", "delighted to have Syntro as a licensee"

Letter dated February 13, 1985 from Katharine Ku to M. James Barrett, Life Technologies, Inc. handwritten note in upper right, "2/13 Stan - If you helped in any way, thank you! Kathy"; "Re: Stanford Docket S74-043, "DNA Cloning", "very pleased to have Life Technologies as a licensee"

Letter dated January 31, 1985 from Katharine Ku to Nanette Newell, Calgene "Re: Stanford Docket S74-043, "DNA Cloning", "delighted to have Calgene as a licensee"

Letter dated January 18, 1985 from Katharine Ku to John Chester, National Science Foundation "Re: Stanford Docket S74-043, "DNA Cloning", request for SNC grant proposals prior to November 4, 1974, "In particular, we would like any research information" for Grant GB30581

Letter dated January 7, 1985 from Katharine Ku to Roger Ditzel, Patent, Trademark & Copyright Office, University of California, cc H. Boyer and SNC; "Re: Stanford Docket S74-043, "DNA Cloning", letter provides "brief summary of the licensing status"

Letter dated January 3, 1985 from Katharine Ku to Donald Perella, Merck & Co., Inc. "Re: Stanford Docket S74-043, "DNA Cloning", returning fully executed copy of licensing agreement; no attachment.

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