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Thomas C. Chalmers Papers 1927-1995
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All Series Level Scope and Content Notes

Research files, teaching materials, correspondence, publications, conference packets and notes, audiovisuals, and personal material (1951-1995; 29 linear feet) document the life and medical career of Thomas C. Chalmers. Materials cover his career from Harvard Medical School to his final work with MetaWorks, Inc. The majority of the collection consists of subject files containing reports, articles, correspondence, and notes concerning his research interest in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. There also exists a small percentage of teaching materials in the subject files from Chalmers' various positions as lecturer and professor of medicine. The bulk of the collection spans the years 1951-1953 and 1970-1995.

The collection is organized into 6 series: Personal and Biographical; Subject Files; Hepatitis Study, Kyoto, Japan; Publications; Conferences; and Audiotapes.

Of significant interest in Series 4: Subject Files, is the material in the Linus Pauling and Vitamin C folders which contain information on Chalmers' debate with Pauling over the efficacy of Vitamin C as a cure for the common cold. These folders include debate transcripts, correspondence, and articles. Also of interest in this series is the MetaWorks Business Plan, 1993. This file folder includes correspondence and a 1993 summary of events relating to the company's inception. In addition, Series 5: Hepatitis Study, Kyoto, Japan is also significant for its documentation of Chalmers' 1951 to 1953 hepatitis study. Chalmers later used this study to disprove the common belief that long periods of bed rest were beneficial to those suffering from acute infectious hepatitis. This series includes correspondence, reports, charts, and other data relating to this study.


This series contains correspondence, notes, and reunion materials relating to Dr. Chalmers' family and personal life. On August 31, 1942, he married his wife Frankie Talcott with whom he had four children. This series includes correspondence with his wife and son Richard, as well as general family letters which detail some of Chalmers' trips abroad. In addition, Chalmers' Philips Exeter Academy Class of 1936 50th Reunion materials are also included in this series. The series is arranged alphabetically by file folder.


This series contains publications, drafts, reports, charts, and notes concerning Chalmers' research interests in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. A small percentage of Chalmers' teaching materials that include teaching plans and syllabi can also be found in this series. The series is arranged alphabetically by file folder.


This series contains correspondence, reports, charts, and other data concerning Chalmers' Hepatitis Study in Japan. In 1951 he was the principal investigator of the hepatitis treatment research unit of Harvard Medical School in Kyoto, Japan. This study was later used by Chalmers to disprove the common belief that long periods of bed rest was beneficial to those suffering from acute infectious hepatitis. The series is arranged alphabetically by file folder.

[RESTRICTED PHI POLICY] Series is restricted according to HMD's access to health information policy. Please consult the Manuscripts Curator for access to these materials.


This series contains copies of Chalmers' published articles in such journals as the New England Journal of Medicine, The American Journal of Medicine, The Sciences, Controlled Clinical Trials, and The Mount Sinai Journal of Medicine. In addition, there are two bibliographies of Chalmers' publications. Among the many covered titles are clinical trials; meta-analysis; clinical gastroenterology and cardiology, and geriatrics.

The series is organized into 6 sub-series covering work he authored at the Mt. Sinai Clinical Trials Unit, the Technology Assessment Group, Harvard School of Public Health, and papers submitted for publication or in press. These sub-series follow Chalmers' original order and numbering system (which is roughly chronological) as found in folder 1 of Papers, Clinical Trials Unit, Mt. Sinai, 1965-1992.


This series contains correspondence, notes, information packets, schedules, and travel documents relating to the various conferences Chalmers attended during the 1980s and early 1990s. The series is arranged alphabetically by file folder.


This series contains two reel-to-reel audiotapes. Documentation on the tapes is poor with one tape lacking any documentation. The "Pathogenesis and Medical Treatment of Ascites Thomas C. Chalmers... " tape also contains lectures by various other speakers; a table of contents is included.