Box | Folder
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Title
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Series 2: Research Contracts,
1965-1999 [series]:
The progress of specific National Heart, Lung, and Blood Institute (NHLBI) contracts is documented in this series. These contracts supported ongoing research into the development of temporary left ventricular assist devices (LVADs), permanent artificial hearts, and energy sources for these devices. They also detail research on the effects of biomaterials coming in contact with blood, atherosclerosis, clinical LVAD trials, and using lab rats and dogs for clinical research. There are five sub-series: Requests for Proposals (RFPs), Applications and Proposals, Reviews, Reports, and General. The first two sub-series contain solicitations to potential contractors for research proposals and the contractors' submissions. The Reviews sub-series consists of material gathered during the review of an application for a new research contract and renewals of existing contracts. This material includes lists of institutions receiving the RFPs, review committee member information, meeting minutes, summary sheets for recommended and not recommended proposals, and approval memos. Reports in the fourth sub-series are quarterly, annual, and final progress reports from the contractors. The General sub-series consists of correspondence, memoranda, reports, license applications, and miscellaneous files relating work done on specific research contracts. Each sub-series is arranged chronologically by folder date.
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Requests For Proposals (RFPs),
1965-1994 [subseries]:
|
8 |
15-18 |
Requests for Proposals,
1965-1973
|
8 |
19-20 |
RFPs - Book 2,
1969-1975
|
8 |
21 |
RFPs - NHLI Budget FY '72,
1971-1972
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8 |
22-24 |
RFAs - RFPs,
1977-1979
|
8 |
25-27 |
RFPs 1980 - DTB,
1979-1981
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8 |
28 |
[RFPs - Fiscal Year 1980],
1980
|
8 |
29 |
[RFA NIH-85-HL-24-H],
1984
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8 |
30 |
[RFP NHLBI-HV-86-01 - "Fabrication of Cardiovascular Devices" (2 copies)],
1985
|
8 |
31 |
Request for Proposal - No. NHLBI-HV-84-01 (R88),
1988
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8 |
32 |
Request for Proposals - [Fiscal Year 1989],
1989
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8 |
33 |
Program Continuation, Request for Applications, FY1990,
1990
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8 |
34 |
[Request for Proposal No. NHLBI-HV-92-28 - "Phased Readiness Testing of Implantable Total Artificial Heart"],
1992
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9 |
1 |
[Request for Proposal No. NHLBI-HV-94-25] "Innovative Ventricular Assist System (IVAS)",
1994
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Applications and Proposals,
1965-1995 [subseries]:
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9 |
2 |
"Proposal for Analytic and Evaluative Services Related to the Development of an Artificial Heart",
1965 Sep 24
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9 |
3 |
"Analysis and Measurement of the Effect of Materials on Blood Leukocytes, Erythrocytes, and Platelets",
1971 Jul 23
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9 |
4 |
"Hybrid Thermal Converter for an Artificial Heart Device",
1972 Apr 24
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9 |
5 |
"Continuation of Clinical Trials of Left Ventricular Assist Devices" - Volume 1 - Technical Proposal,
1976 Jul
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9 |
6 |
"Continuation of Clinical Trials of Left Ventricular Assist Devices" - Volume 2 - Management Proposal,
1976 Jul
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9 |
7 |
"The Clinical Applications of the Left Ventricular Assist Device" - N01-HV-5-3007 - Business Proposal,
1976 Jul
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9 |
8 |
"The Clinical Applications of the Left Ventricular Assist Device" - N01-HV-5-3007 - Technical Proposal,
1976 Jul
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9 |
9 |
["Continuation of Clinical Trials of Left Ventricular Assist Devices" - Volume 2 - Management Proposal], N01-HV-5-3006,
1977 Jul 13
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9 |
10 |
[Unsolicited Contract Proposal - Technical Proposal - "Biological Effects of Implanted Nuclear Energy Sources for Artificial Heart Devices"] [photograph],
1977 Dec 23
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9 |
11 |
[RFP NHLBI-79-11 - Technical Proposal - "Procurement of Primary Reference Materials"],
1979 Mar 23
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9 |
12 |
N01-HV-9-2933 - "Procurement of Primary Reference Materials" - [Renewal] Business Proposal,
1982 May 28
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9 |
13-14 |
N01-HV-9-2933 - "Procurement of Primary Reference Materials" - [Renewal] Technical Proposal,
1982 May 28
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9 |
15-16 |
["Device Readiness Testing of the Novacor Implantable Permanent Left Ventricular Assist System" -] Novacor Medical Corporation - Technical Proposal [- Volume II, Appendices],
1984 Feb
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9 |
17 |
[N01-HV-48070 - "In Vivo Endurance and Characterization] Testing of the MK IV Ventricular Assist System",
1986 Jul
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9 |
18-20 |
["Development of the Novacor Implantable Cardiac Biventricular Assist System" - Technical Proposal - Volume II, Appendices],
1986 Nov
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9 |
21-24 |
"Development of a Biventricular Replacement Device" - NHLBI-HV-86-02 - Technical Proposal - Volume I of II [photograph],
1986 Nov 14
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9 |
25 |
["Development of a Biventricular Replacement Device" -] NHLBI-HV-86-02 - Technical Proposal - Volume II of II,
1986 Nov 14
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9 |
26-29 |
Novacor - Volume I,
1988 Oct 10
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9 |
30-32 |
Novacor - Volume II, Appendices,
1988 Oct 10
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9 |
33 |
RFP NHLBI-HV-89-10 - "Clinical Centers for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refractory Heart Failure" - Business Proposal,
1989 Oct 9
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9 |
34-37 |
St. Louis University - N01-HV-08113 - ["Clinical Centers for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refractory Heart Failure"],
1989-1990
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10 |
1-3 |
St. Louis University - N01-HV-08113 - ["Clinical Centers for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refractory Heart Failure"],
1989-1990
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10 |
4-5 |
[RFP NHLBI-HV-94-25 -] "Datascope Innovative Ventricular Assist (DIVA) System" - Technical Proposal,
1994 Nov 30
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10 |
6 |
"Proposal for the Development of an Artificial Myocardium",
1994 Dec 2
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10 |
7-8 |
[RFP NHLBI-HV-94-25 - "Innovative Left Ventricular Assist System" - Technical Proposal - New York Medical College],
1994 Dec 2
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10 |
9-12 |
RFP NHLBI-HV-94-25 - "Innovative Ventricular Assist System (IVAS)" - Volume I - Technical Proposal - Cleveland Clinic Foundation,
1994 Dec 2
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10 |
13 |
RFP NHLBI-HV-94-25 - ["Innovative Ventricular Assist System] (IVAS)" - Volume II - Business Proposal - Cleveland Clinic Foundation,
1994 Dec 2
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10 |
14-15 |
["Innovative Ventricular Assist System (IVAS)" - University of Florida],
1994 Dec 3
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10 |
16-17 |
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Transicoil Technical Proposal,
1994 Dec 5
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10 |
18-19 |
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Transicoil Business Proposal,
1994 Dec 5
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10 |
20-21 |
NHLBI-HV-94-25 - "Innovative Ventricular Assist System (IVAS)" - Technical Proposal [Washington University School of Medicine],
1994 Dec
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10 |
22-27 |
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Volume I - Technical Proposal - Whalen Biomedical Incorporated,
1994 [Dec 7]
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11 |
1 |
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Volume II - Business Proposal - Whalen Biomedical Incorporated,
1994 Dec 7
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11 |
2 |
[RFP] NHLBI-HV-94-25 (IVAS) [- Cleveland Clinic Foundation] Response to Enquiries,
1995 Apr 6
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11 |
3 |
RFP NHLBI-HV-94-25 (IVAS) - [Nimbus Inc's] Answers to Reviewers' Questions,
1995 Apr 10
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11 |
4 |
[RFP] NHLBI-HV-94-25 (IVAS) - [Washington University's] Answers to Reviewers' Questions on Technical Proposal,
1995 Apr
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11 |
5 |
[RFP NHLBI-HV-94-25 -] "Proposal for Development of an Artificial Myocardium" [- Responses to Questions],
1995 Apr
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11 |
6 |
RFP NHLBI-HV-94-25 (IVAS) - Transicoil Responses to Additional Question,
1995 Jun 23
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11 |
7 |
[RFP NHLBI-HV-94-25 (IVAS) - Whalen Biomedical Incorporated Responses, Copy No. 3, 4],
1995
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Reviews,
1971-1990 [subseries]:
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New Contracts,
1971-1990 [subseries]:
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11 |
8 |
RFP-NHLI-71-5 - "Fabrication of Oxygenators Using Specified Materials",
1971
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11 |
9-10 |
RFP-NHLI-71-15 - ["Systems Analysis Study for the Establishment and Conduct of a Research and Development Program for Respiratory Devices"],
1971
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11 |
11-12 |
RFP NHLI-MDAP-72-19 - "Materials Development and Testing",
1972
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11 |
13-14 |
RFP NHLI-MDAP-72-20 - ["Instrumentation for Development and Utilization of Medical Devices and for Patient Diagnosis and Monitoring"],
1972-1973
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11 |
15-16 |
RFP-NHLI-HB 74-16 - "Improved Biological Test Procedures for Evaluation of Biomaterials in Contact with Blood",
1974
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11 |
17-18 |
RFP-NHLI-HB-74-17 - "Interactions of Natural and Chemically Modified Biopolymers with Blood",
1974
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11 |
19-20 |
RFP NHLI-75-14 - ["Improved Instrumentation and Techniques for] Non-invasive Detection, Characterization, and Quantification of Atherosclerosis [for Research and Diagnostic Applications"],
1974-1975
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11 |
21-22 |
RFP 77-7 ["Development and Evaluation of Instrument Systems for Non-invasive Detection, Characterization and Quantification of Atherosclerotic Lesions"],
1977
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11 |
23 |
RFP 77-8 - Approval Memo [- "Left Heart Assist Blood Pumps"],
1977
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11 |
24-25 |
RFP 77-9 - Approval Memo - "Development of Electrical Energy Converters to Power and Control Left Heart Assist Devices",
1977
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11 |
26 |
RFP 77-10 - Approval Memo - ["Development of Percutaneous Leads or Other Energy Transmission Techniques and Devices"],
1977
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11 |
27 |
RFP 77-11 - Approval Memo - ["Physical Testing of Polymers for Use in Circulatory Assist Devices"],
1977
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11 |
28 |
RFP 78-2 [- "Research and Development of Percutaneous Energy Transmission Systems"],
1977-1978
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12 |
1 |
RFP 78-2 [- "Research and Development of Percutaneous Energy Transmission Systems"],
1977-1978
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12 |
2 |
RFP 79-3 - "Development of a Thermal Energy [Converter for Implantable Circulatory Support Devices"],
1979
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12 |
3 |
RFP 79-4 - "Fabrication of Cardiovascular Devices",
1978-1979
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12 |
4-5 |
RFP 79-11 [- "Procurement of Primary Reference Materials"],
1978-1980
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12 |
6-8 |
RFP 79-12 - "Blood Compatibility of Circulatory Assist Devices",
1978-1979
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12 |
9-10 |
RFP 80-1 [- "Research and Development for Systems for Transmitting Energy Through the Intact Skin"],
1979-1980
|
12 |
11-12 |
RFP 80-2 [- "Clinical Evaluation of Ventricular Assist Devices"],
1979-1980
|
12 |
13-14 |
[RFP 80-3 - "Development of an Implantable Integrated Electrically Powered Left Heart Assist System"],
1979-1980
|
12 |
15-20 |
RFP 80-5 [- "Research, Development and Evaluation of Systems for Noninvasive Detection and Quantification of Atherosclerotic Lesions in Peripheral and Coronary Arteries"],
1980
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12 |
21 |
RFP 81-1 ["Research and Development of Percutaneous Energy Transmission System"],
1980-1981
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12 |
22 |
RFP 82-3 - "Development of an Implantable Integrated Thermally Powered Ventricular Assist System",
1981-1982
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13 |
1 |
[RFP 82-3 - "Development of an Implantable Integrated Thermally Powered Ventricular Assist System"],
1981-1982
|
13 |
2-5 |
[RFP 83-6 - "Research, Development and Evaluation of Minimally Invasive Systems for Detection and Quantification of Atherosclerotic Lesions in Coronary Arteries of Humans"],
1982-1983
|
13 |
6-9 |
RFP 84-1 - ["Device Readiness Testing of Implantable Ventricular Assist Systems"],
1983-1984
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13 |
10 |
RFP 82-3 [(R-86)] - "Development of an Implantable Integrated Thermally Powered Ventricular Assist System",
1985-1986
|
13 |
11-14 |
[RFP 86-02 - "Development of Implantable Cardiac Biventricular Assist and Replacement Devices"],
1985-1987
|
13 |
15-16 |
RFP 84-01 (R-88) [- "Clinical Ventricular Assist System Production, Support and Evaluation"],
1988-1989
|
13 |
17-20 |
RFP 89-9 and RFP 89-10,
1988-1990
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Renewals,
1971-1986 [subseries]:
|
13 |
21 |
Materials - Review Extension Proposals,
1971
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13 |
22 |
Contract Renewals - Energy Systems,
1972
|
14 |
1 |
Renewal of "Implanted Assist and Total Heart [Power and Control] Systems",
1972
|
14 |
2 |
[Renewal of Five Biomaterials Contracts],
1973
|
14 |
3 |
Contracts Renewal Review - "Implantable Energy Systems [for Cardiac Assist and Total Heart Replacement Devices"],
1974 Jun
|
14 |
4 |
Biomaterials Contract Renewal - Proposal Reviews,
1974 Sep
|
14 |
5 |
Proposal Review Summary - "The Evaluation of Temporary Left Ventricular Assist Device for Clinical Application",
1974 Oct
|
14 |
6 |
[Request for Non-competitive Contract Renewal for Fabrication Contracts],
1975 Jun
|
14 |
7 |
Blood Pump Contracts Renewal Review,
1975 Oct
|
14 |
8 |
Contract Renewal Proposals Review Blood Pumps and Biomaterials,
1976 May
|
14 |
9 |
Review of Energy Contracts Renewals,
1974-1976
|
14 |
10 |
Renewal Contract Proposal [Reviews],
1977
|
14 |
11 |
[Contract Renewals - "Procurement of Primary Reference Materials"],
1981-1982
|
14 |
12 |
[N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Renewal Documents],
1982
|
14 |
13 |
[Renewal of Contracts for "Fabrication of Cardiovascular Devices"],
1982
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14 |
14 |
[Renewal of Contract for "Fabrication of Cardiovascular Devices"],
1985-1986
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Reports,
1968-1998 [subseries]:
|
14 |
15 |
"Electrical Energy Systems to Power Circulatory Assist Devices" - Task Report,
1968 Jan
|
14 |
16 |
"Studies of the Ovine Thorax and Associated Structures",
1969
|
14 |
17 |
Quarterly Progress Report - "Evaluation of Temporary Left Ventricular Assist Pumping" - N01-HV-3-2946,
1975 Feb
|
14 |
18-19 |
[Annual Report - "Continuation of the Fabrication of Implantable Artificial Heart Devices and Components"],
1975 May
|
14 |
20 |
Axisymetric LVAD [Annual Technical Report - "Development and Evaluation of Unilateral and Bilateral Cardiac Assist Devices"],
1975 Sep
|
14 |
21 |
Topical Report - N01-HV-5-3008 - "Pre-Clinical Evaluation of Temporary Left Ventricular Assist Pumping",
1975 Oct 22
|
14 |
22 |
Compilation of Contract Status Reports,
1976 Jan
|
14 |
23 |
[Annual Technical Progress Report - "The Clinical Applications of the Left Ventricular Assist Device"],
1976 Jun
|
14 |
24 |
"The Clinical Applications of the Left Ventricular Assist Device," N01-HV-5-3007 - Annual Report,
1976 Jul
|
14 |
25 |
Report to Cardiology Advisory Committee [- NHLBI Program #1-HV-5-3007],
1978 Oct
|
14 |
26 |
[Contract Status Reports],
1978-1979
|
14 |
27-28 |
"ALVAD: 1980 - A Comprehensive Final Report to NHLBI," N01-HV-5-3006 [Annual Technical Progress Report],
1980 Jan
|
14 |
29 |
[Annual Report - "Development of a Reversing Electrohydraulic Energy Converter for Left Ventricular Assist Devices," N01-HV-72975],
1980 Jan
|
14 |
30 |
"Investigation of Adhesion of Silicone Primary Reference Samples to Coated Packaging Material",
1981 Mar 15
|
14 |
31 |
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Progress Report,
1981
|
14 |
32 |
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Second Annual Progress Report,
1981 Jun 8
|
14 |
33 |
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Third Annual Progress Report - Draft,
1982
|
14 |
34 |
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Third Annual Progress Report,
1982 Jun
|
14 |
35 |
N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Progress Reports,
198[2]-1983
|
15 |
1-3 |
N01-HV-12908 - "Clinical Evaluation of Ventricular Assist Devices" [Annual Report],
1983 Jan 18
|
15 |
4 |
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Fourth Annual Progress Report,
1983 Jul 15
|
15 |
5-6 |
"Implanted Thermal Engine System Development" - N01-HV-28002 [Annual Report],
1983 Jul
|
15 |
7 |
[N01-HV 38043 - Second Annual Report - "Research, Development and Evaluation of Minimally Invasive Systems for Detection and Quantification of Atherosclerotic Lesions in Coronary Arteries in Humans"],
1985 Oct 1
|
15 |
8 |
"Device Readiness Testing of Implantable Ventricular Assist Systems" - N01-HV-48070 [Annual Technical Progress Report],
1986 Mar 1
|
15 |
9 |
[EHTAH Project, University of Utah Quarterly Report],
1988 Jun 30
|
15 |
10 |
Technical Reports from Contracts,
1988 Nov
|
15 |
11 |
Draft - Final Report - "Implanted Thermal Engine System Development",
1989 Jul 14
|
15 |
12 |
[Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device"],
1990 Jan
|
15 |
13 |
Quarterly Report - #N01-HV-88106 - "Development of a Biventricular Replacement Device",
1990 Apr
|
15 |
14-15 |
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device",
1990 Aug
|
15 |
16 |
"Development of an Electrohydraulic Total Artificial Heart" - [Third Annual Report],
1990 Oct 20
|
15 |
17 |
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device",
1991 Feb
|
15 |
18 |
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device",
1991 Apr
|
15 |
19-20 |
"Development of a Biventricular Replacement Device" - Annual Report,
1991 Oct
|
15 |
21 |
"Development of Totally Implantable Cardiac Replacement Device" [Annual Report],
1991 Nov
|
15 |
22-23 |
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device",
1992 Apr
|
15 |
24 |
[Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device"],
1992 Aug
|
15 |
25 |
"Development of a Biventricular Replacement Device" - N01-HV-88106 [Annual Report],
1992 Nov
|
15 |
26 |
Quarterly Report for "Development of an Electrohydraulic Total Artificial Heart" - Contract No. N01-HV-88104,
1993 Apr 30
|
15 |
27-28 |
N01-HV-048072/N01-HV-98107 - "Device Readiness Testing and Clinical Production of the Novacor Totally Implantable Left Ventricular Assist System" [Final Report],
1993 Oct
|
15 |
29-30 |
E4T Total Artificial Heart Program Plan - NHLBI Contract N01-HV-38129,
1996 Jun 10
|
15 |
31 |
[N01-HV-38128, "Testing of an Electrohydraulic Total Artificial Heart" - Fifth Annual Report],
1998 Jul
|
15 |
32 |
Contract N01-HV-58158 - "Innovative Ventricular Assist System (IVAS)" - Annual Report,
1998
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General,
1967-1999 [subseries]:
|
15 |
33 |
License Application for Pu-238 Fuel Capsule,
1967 May
|
15 |
34 |
Pacemakers,
1971-1972
|
16 |
1-3 |
HL 14913 (CVB) [Hypertension] - New P.I. - Dr. Junichi Iwai (formerly Dr. Lewis K. Dahl),
1971-1981
|
16 |
4 |
[Performance Growth Capabilities of TRW Hybrid Thermal Converter],
1972 Sep 15
|
16 |
5 |
[Miscellaneous Contract Administrative Files],
1973-1981, 1988-1991, n.d.
|
16 |
6 |
[LVAD Contract Correspondence],
1974-1976
|
16 |
7-8 |
LVAD Office [negative],
1975-1979
|
16 |
9 |
ERDA Site Review Report,
1976 Feb 18
|
16 |
10-11 |
Children's Hospital Medical Center (CHMC) Correspondence,
1976
|
16 |
12 |
[LVAD] Case file,
1976
|
16 |
13 |
Texas Heart Institute (THI) Correspondence,
1976
|
16 |
14 |
[N01-HV-1-2060 Work Status],
1977 Mar 23
|
16 |
15 |
[Instrument Systems for Non-invasive Detection, Characterization and Quantification of Atherosclerotic Lesions],
1977
|
16 |
16-17 |
Cornell Dog Study [photograph],
1977-1978
|
16 |
18-19 |
[Dahl] S/R [Rats] Users Panel,
1979-1983
|
16 |
20-22 |
[Dahl S/R Rats -] Y01-HV-00031 - Interagency Agreement,
1979-1983
|
16 |
23 |
Program Plan, RFA NIH-NHLBI-82G-H: Mechanisms of Calcification of Prosthetic Materials in the Cardiovascular System,
1982
|
16 |
24-25 |
N01-HV-38043 - University of Wisconsin - [Contract file] [photographs, slides],
1983-1991
|
16 |
26 |
Research and Development Grants,
1985 Nov
|
16 |
27 |
["Clinical Ventricular Assist System Production, Support and Evaluation" - Source Selection Document/Funding],
1988
|
16 |
28 |
["Intraventricular Axial-Flow-Pump Artificial Heart"],
1988-1992
|
16 |
29 |
Retrospective Reliability Analysis of the Electrohydraulic Total Artificial Heart,
1989 Apr 27
|
16 |
30 |
[Novacor LVAS/Baxter],
1989-1991
|
16 |
31 |
NIH Site Visit [Presentation by the EHTAH Project Team, Artificial Heart Research Laboratory, University of Utah],
1990 Feb 21
|
16 |
32 |
Review of Activities to Develop a Thermal Ventricular Assist System TVAS,
1990 Jul 23
|
16 |
33 |
New England Research Institute - N01-HV-08111 [- "Data Coordinating Center for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refracting Heart Failure"],
1990-1994
|
16 |
34 |
Baxter-Novacor,
1991-1993
|
33 |
1 |
[Technical Data Package for the Electro-Hydraulic Total Artificial Heart (EHTAH) Volume VII of VII],
1993 Oct 1
|
16 |
35 |
Innovative Ventricular Assist System (IVAS) Program Plan,
1995 Oct 31
|
16 |
36 |
Tissue Engineering, Biometrics, and Medical Implant Science [Program Plan] [photographs],
1998 May 14
|