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John T. Watson Papers 1964-2003
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Series II: Research Contracts, 1965-1999 [series]:

The progress of specific National Heart, Lung, and Blood Institute (NHLBI) contracts is documented in this series. These contracts supported ongoing research into the development of temporary left ventricular assist devices (LVADs), permanent artificial hearts, and energy sources for these devices. They also detail research on the effects of biomaterials coming in contact with blood, atherosclerosis, clinical LVAD trials, and using lab rats and dogs for clinical research. There are five sub-series: Requests for Proposals (RFPs), Applications and Proposals, Reviews, Reports, and General. The first two sub-series contain solicitations to potential contractors for research proposals and the contractors' submissions. The Reviews sub-series consists of material gathered during the review of an application for a new research contract and renewals of existing contracts. This material includes lists of institutions receiving the RFPs, review committee member information, meeting minutes, summary sheets for recommended and not recommended proposals, and approval memos. Reports in the fourth sub-series are quarterly, annual, and final progress reports from the contractors. The General sub-series consists of correspondence, memoranda, reports, license applications, and miscellaneous files relating work done on specific research contracts. Each sub-series is arranged chronologically by folder date.

 
Requests For Proposals (RFPs), 1965-1994 [subseries]:
8 15-18
Requests for Proposals, 1965-1973
8 19-20
RFPs - Book 2, 1969-1975
8 21
RFPs - NHLI Budget FY '72, 1971-1972
8 22-24
RFAs - RFPs, 1977-1979
8 25-27
RFPs 1980 - DTB, 1979-1981
8 28
[RFPs - Fiscal Year 1980], 1980
8 29
[RFA NIH-85-HL-24-H], 1984
8 30
[RFP NHLBI-HV-86-01 - "Fabrication of Cardiovascular Devices" (2 copies)], 1985
8 31
Request for Proposal - No. NHLBI-HV-84-01 (R88), 1988
8 32
Request for Proposals - [Fiscal Year 1989], 1989
8 33
Program Continuation, Request for Applications, FY1990, 1990
8 34
[Request for Proposal No. NHLBI-HV-92-28 - "Phased Readiness Testing of Implantable Total Artificial Heart"], 1992
9 1
[Request for Proposal No. NHLBI-HV-94-25] "Innovative Ventricular Assist System (IVAS)", 1994
 
Applications and Proposals, 1965-1995 [subseries]:
9 2
"Proposal for Analytic and Evaluative Services Related to the Development of an Artificial Heart", 1965 Sep 24
9 3
"Analysis and Measurement of the Effect of Materials on Blood Leukocytes, Erythrocytes, and Platelets", 1971 Jul 23
9 4
"Hybrid Thermal Converter for an Artificial Heart Device", 1972 Apr 24
9 5
"Continuation of Clinical Trials of Left Ventricular Assist Devices" - Volume 1 - Technical Proposal, 1976 Jul
9 6
"Continuation of Clinical Trials of Left Ventricular Assist Devices" - Volume 2 - Management Proposal, 1976 Jul
9 7
"The Clinical Applications of the Left Ventricular Assist Device" - N01-HV-5-3007 - Business Proposal, 1976 Jul
9 8
"The Clinical Applications of the Left Ventricular Assist Device" - N01-HV-5-3007 - Technical Proposal, 1976 Jul
9 9
["Continuation of Clinical Trials of Left Ventricular Assist Devices" - Volume 2 - Management Proposal], N01-HV-5-3006, 1977 Jul 13
9 10
[Unsolicited Contract Proposal - Technical Proposal - "Biological Effects of Implanted Nuclear Energy Sources for Artificial Heart Devices"] [photograph], 1977 Dec 23
9 11
[RFP NHLBI-79-11 - Technical Proposal - "Procurement of Primary Reference Materials"], 1979 Mar 23
9 12
N01-HV-9-2933 - "Procurement of Primary Reference Materials" - [Renewal] Business Proposal, 1982 May 28
9 13-14
N01-HV-9-2933 - "Procurement of Primary Reference Materials" - [Renewal] Technical Proposal, 1982 May 28
9 15-16
["Device Readiness Testing of the Novacor Implantable Permanent Left Ventricular Assist System" -] Novacor Medical Corporation - Technical Proposal [- Volume II, Appendices], 1984 Feb
9 17
[N01-HV-48070 - "In Vivo Endurance and Characterization] Testing of the MK IV Ventricular Assist System", 1986 Jul
9 18-20
["Development of the Novacor Implantable Cardiac Biventricular Assist System" - Technical Proposal - Volume II, Appendices], 1986 Nov
9 21-24
"Development of a Biventricular Replacement Device" - NHLBI-HV-86-02 - Technical Proposal - Volume I of II [photograph], 1986 Nov 14
9 25
["Development of a Biventricular Replacement Device" -] NHLBI-HV-86-02 - Technical Proposal - Volume II of II, 1986 Nov 14
9 26-29
Novacor - Volume I, 1988 Oct 10
9 30-32
Novacor - Volume II, Appendices, 1988 Oct 10
9 33
RFP NHLBI-HV-89-10 - "Clinical Centers for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refractory Heart Failure" - Business Proposal, 1989 Oct 9
9 34-37
St. Louis University - N01-HV-08113 - ["Clinical Centers for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refractory Heart Failure"], 1989-1990
10 1-3
St. Louis University - N01-HV-08113 - ["Clinical Centers for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refractory Heart Failure"], 1989-1990
10 4-5
[RFP NHLBI-HV-94-25 -] "Datascope Innovative Ventricular Assist (DIVA) System" - Technical Proposal, 1994 Nov 30
10 6
"Proposal for the Development of an Artificial Myocardium", 1994 Dec 2
10 7-8
[RFP NHLBI-HV-94-25 - "Innovative Left Ventricular Assist System" - Technical Proposal - New York Medical College], 1994 Dec 2
10 9-12
RFP NHLBI-HV-94-25 - "Innovative Ventricular Assist System (IVAS)" - Volume I - Technical Proposal - Cleveland Clinic Foundation, 1994 Dec 2
10 13
RFP NHLBI-HV-94-25 - ["Innovative Ventricular Assist System] (IVAS)" - Volume II - Business Proposal - Cleveland Clinic Foundation, 1994 Dec 2
10 14-15
["Innovative Ventricular Assist System (IVAS)" - University of Florida], 1994 Dec 3
10 16-17
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Transicoil Technical Proposal, 1994 Dec 5
10 18-19
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Transicoil Business Proposal, 1994 Dec 5
10 20-21
NHLBI-HV-94-25 - "Innovative Ventricular Assist System (IVAS)" - Technical Proposal [Washington University School of Medicine], 1994 Dec
10 22-27
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Volume I - Technical Proposal - Whalen Biomedical Incorporated, 1994 [Dec 7]
11 1
RFP NHLBI-HV-94-25 ["Innovative Ventricular Assist System] (IVAS)" - Volume II - Business Proposal - Whalen Biomedical Incorporated, 1994 Dec 7
11 2
[RFP] NHLBI-HV-94-25 (IVAS) [- Cleveland Clinic Foundation] Response to Enquiries, 1995 Apr 6
11 3
RFP NHLBI-HV-94-25 (IVAS) - [Nimbus Inc's] Answers to Reviewers' Questions, 1995 Apr 10
11 4
[RFP] NHLBI-HV-94-25 (IVAS) - [Washington University's] Answers to Reviewers' Questions on Technical Proposal, 1995 Apr
11 5
[RFP NHLBI-HV-94-25 -] "Proposal for Development of an Artificial Myocardium" [- Responses to Questions], 1995 Apr
11 6
RFP NHLBI-HV-94-25 (IVAS) - Transicoil Responses to Additional Question, 1995 Jun 23
11 7
[RFP NHLBI-HV-94-25 (IVAS) - Whalen Biomedical Incorporated Responses, Copy No. 3, 4], 1995
 
Reviews, 1971-1990 [subseries]:
 
New Contracts, 1971-1990 [subseries]:
11 8
RFP-NHLI-71-5 - "Fabrication of Oxygenators Using Specified Materials", 1971
11 9-10
RFP-NHLI-71-15 - ["Systems Analysis Study for the Establishment and Conduct of a Research and Development Program for Respiratory Devices"], 1971
11 11-12
RFP NHLI-MDAP-72-19 - "Materials Development and Testing", 1972
11 13-14
RFP NHLI-MDAP-72-20 - ["Instrumentation for Development and Utilization of Medical Devices and for Patient Diagnosis and Monitoring"], 1972-1973
11 15-16
RFP-NHLI-HB 74-16 - "Improved Biological Test Procedures for Evaluation of Biomaterials in Contact with Blood", 1974
11 17-18
RFP-NHLI-HB-74-17 - "Interactions of Natural and Chemically Modified Biopolymers with Blood", 1974
11 19-20
RFP NHLI-75-14 - ["Improved Instrumentation and Techniques for] Non-invasive Detection, Characterization, and Quantification of Atherosclerosis [for Research and Diagnostic Applications"], 1974-1975
11 21-22
RFP 77-7 ["Development and Evaluation of Instrument Systems for Non-invasive Detection, Characterization and Quantification of Atherosclerotic Lesions"], 1977
11 23
RFP 77-8 - Approval Memo [- "Left Heart Assist Blood Pumps"], 1977
11 24-25
RFP 77-9 - Approval Memo - "Development of Electrical Energy Converters to Power and Control Left Heart Assist Devices", 1977
11 26
RFP 77-10 - Approval Memo - ["Development of Percutaneous Leads or Other Energy Transmission Techniques and Devices"], 1977
11 27
RFP 77-11 - Approval Memo - ["Physical Testing of Polymers for Use in Circulatory Assist Devices"], 1977
11 28
RFP 78-2 [- "Research and Development of Percutaneous Energy Transmission Systems"], 1977-1978
12 1
RFP 78-2 [- "Research and Development of Percutaneous Energy Transmission Systems"], 1977-1978
12 2
RFP 79-3 - "Development of a Thermal Energy [Converter for Implantable Circulatory Support Devices"], 1979
12 3
RFP 79-4 - "Fabrication of Cardiovascular Devices", 1978-1979
12 4-5
RFP 79-11 [- "Procurement of Primary Reference Materials"], 1978-1980
12 6-8
RFP 79-12 - "Blood Compatibility of Circulatory Assist Devices", 1978-1979
12 9-10
RFP 80-1 [- "Research and Development for Systems for Transmitting Energy Through the Intact Skin"], 1979-1980
12 11-12
RFP 80-2 [- "Clinical Evaluation of Ventricular Assist Devices"], 1979-1980
12 13-14
[RFP 80-3 - "Development of an Implantable Integrated Electrically Powered Left Heart Assist System"], 1979-1980
12 15-20
RFP 80-5 [- "Research, Development and Evaluation of Systems for Noninvasive Detection and Quantification of Atherosclerotic Lesions in Peripheral and Coronary Arteries"], 1980
12 21
RFP 81-1 ["Research and Development of Percutaneous Energy Transmission System"], 1980-1981
12 22
RFP 82-3 - "Development of an Implantable Integrated Thermally Powered Ventricular Assist System", 1981-1982
13 1
[RFP 82-3 - "Development of an Implantable Integrated Thermally Powered Ventricular Assist System"], 1981-1982
13 2-5
[RFP 83-6 - "Research, Development and Evaluation of Minimally Invasive Systems for Detection and Quantification of Atherosclerotic Lesions in Coronary Arteries of Humans"], 1982-1983
13 6-9
RFP 84-1 - ["Device Readiness Testing of Implantable Ventricular Assist Systems"], 1983-1984
13 10
RFP 82-3 [(R-86)] - "Development of an Implantable Integrated Thermally Powered Ventricular Assist System", 1985-1986
13 11-14
[RFP 86-02 - "Development of Implantable Cardiac Biventricular Assist and Replacement Devices"], 1985-1987
13 15-16
RFP 84-01 (R-88) [- "Clinical Ventricular Assist System Production, Support and Evaluation"], 1988-1989
13 17-20
RFP 89-9 and RFP 89-10, 1988-1990
 
Renewals, 1971-1986 [subseries]:
13 21
Materials - Review Extension Proposals, 1971
13 22
Contract Renewals - Energy Systems, 1972
14 1
Renewal of "Implanted Assist and Total Heart [Power and Control] Systems", 1972
14 2
[Renewal of Five Biomaterials Contracts], 1973
14 3
Contracts Renewal Review - "Implantable Energy Systems [for Cardiac Assist and Total Heart Replacement Devices"], 1974 Jun
14 4
Biomaterials Contract Renewal - Proposal Reviews, 1974 Sep
14 5
Proposal Review Summary - "The Evaluation of Temporary Left Ventricular Assist Device for Clinical Application", 1974 Oct
14 6
[Request for Non-competitive Contract Renewal for Fabrication Contracts], 1975 Jun
14 7
Blood Pump Contracts Renewal Review, 1975 Oct
14 8
Contract Renewal Proposals Review Blood Pumps and Biomaterials, 1976 May
14 9
Review of Energy Contracts Renewals, 1974-1976
14 10
Renewal Contract Proposal [Reviews], 1977
14 11
[Contract Renewals - "Procurement of Primary Reference Materials"], 1981-1982
14 12
[N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Renewal Documents], 1982
14 13
[Renewal of Contracts for "Fabrication of Cardiovascular Devices"], 1982
14 14
[Renewal of Contract for "Fabrication of Cardiovascular Devices"], 1985-1986
 
Reports, 1968-1998 [subseries]:
14 15
"Electrical Energy Systems to Power Circulatory Assist Devices" - Task Report, 1968 Jan
14 16
"Studies of the Ovine Thorax and Associated Structures", 1969
14 17
Quarterly Progress Report - "Evaluation of Temporary Left Ventricular Assist Pumping" - N01-HV-3-2946, 1975 Feb
14 18-19
[Annual Report - "Continuation of the Fabrication of Implantable Artificial Heart Devices and Components"], 1975 May
14 20
Axisymetric LVAD [Annual Technical Report - "Development and Evaluation of Unilateral and Bilateral Cardiac Assist Devices"], 1975 Sep
14 21
Topical Report - N01-HV-5-3008 - "Pre-Clinical Evaluation of Temporary Left Ventricular Assist Pumping", 1975 Oct 22
14 22
Compilation of Contract Status Reports, 1976 Jan
14 23
[Annual Technical Progress Report - "The Clinical Applications of the Left Ventricular Assist Device"], 1976 Jun
14 24
"The Clinical Applications of the Left Ventricular Assist Device," N01-HV-5-3007 - Annual Report, 1976 Jul
14 25
Report to Cardiology Advisory Committee [- NHLBI Program #1-HV-5-3007], 1978 Oct
14 26
[Contract Status Reports], 1978-1979
14 27-28
"ALVAD: 1980 - A Comprehensive Final Report to NHLBI," N01-HV-5-3006 [Annual Technical Progress Report], 1980 Jan
14 29
[Annual Report - "Development of a Reversing Electrohydraulic Energy Converter for Left Ventricular Assist Devices," N01-HV-72975], 1980 Jan
14 30
"Investigation of Adhesion of Silicone Primary Reference Samples to Coated Packaging Material", 1981 Mar 15
14 31
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Progress Report, 1981
14 32
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Second Annual Progress Report, 1981 Jun 8
14 33
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Third Annual Progress Report - Draft, 1982
14 34
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Third Annual Progress Report, 1982 Jun
14 35
N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Progress Reports, 198[2]-1983
15 1-3
N01-HV-12908 - "Clinical Evaluation of Ventricular Assist Devices" [Annual Report], 1983 Jan 18
15 4
Contract No. N01-HV-9-2933 - "Procurement of Primary Reference Materials" - Fourth Annual Progress Report, 1983 Jul 15
15 5-6
"Implanted Thermal Engine System Development" - N01-HV-28002 [Annual Report], 1983 Jul
15 7
[N01-HV 38043 - Second Annual Report - "Research, Development and Evaluation of Minimally Invasive Systems for Detection and Quantification of Atherosclerotic Lesions in Coronary Arteries in Humans"], 1985 Oct 1
15 8
"Device Readiness Testing of Implantable Ventricular Assist Systems" - N01-HV-48070 [Annual Technical Progress Report], 1986 Mar 1
15 9
[EHTAH Project, University of Utah Quarterly Report], 1988 Jun 30
15 10
Technical Reports from Contracts, 1988 Nov
15 11
Draft - Final Report - "Implanted Thermal Engine System Development", 1989 Jul 14
15 12
[Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device"], 1990 Jan
15 13
Quarterly Report - #N01-HV-88106 - "Development of a Biventricular Replacement Device", 1990 Apr
15 14-15
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device", 1990 Aug
15 16
"Development of an Electrohydraulic Total Artificial Heart" - [Third Annual Report], 1990 Oct 20
15 17
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device", 1991 Feb
15 18
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device", 1991 Apr
15 19-20
"Development of a Biventricular Replacement Device" - Annual Report, 1991 Oct
15 21
"Development of Totally Implantable Cardiac Replacement Device" [Annual Report], 1991 Nov
15 22-23
Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device", 1992 Apr
15 24
[Quarterly Report - NIH Contract #N01-HV-88106 - "Development of a Biventricular Replacement Device"], 1992 Aug
15 25
"Development of a Biventricular Replacement Device" - N01-HV-88106 [Annual Report], 1992 Nov
15 26
Quarterly Report for "Development of an Electrohydraulic Total Artificial Heart" - Contract No. N01-HV-88104, 1993 Apr 30
15 27-28
N01-HV-048072/N01-HV-98107 - "Device Readiness Testing and Clinical Production of the Novacor Totally Implantable Left Ventricular Assist System" [Final Report], 1993 Oct
15 29-30
E4T Total Artificial Heart Program Plan - NHLBI Contract N01-HV-38129, 1996 Jun 10
15 31
[N01-HV-38128, "Testing of an Electrohydraulic Total Artificial Heart" - Fifth Annual Report], 1998 Jul
15 32
Contract N01-HV-58158 - "Innovative Ventricular Assist System (IVAS)" - Annual Report, 1998
 
General, 1967-1999 [subseries]:
15 33
License Application for Pu-238 Fuel Capsule, 1967 May
15 34
Pacemakers, 1971-1972
16 1-3
HL 14913 (CVB) [Hypertension] - New P.I. - Dr. Junichi Iwai (formerly Dr. Lewis K. Dahl), 1971-1981
16 4
[Performance Growth Capabilities of TRW Hybrid Thermal Converter], 1972 Sep 15
16 5
[Miscellaneous Contract Administrative Files], 1973-1981, 1988-1991, n.d.
16 6
[LVAD Contract Correspondence], 1974-1976
16 7-8
LVAD Office [negative], 1975-1979
16 9
ERDA Site Review Report, 1976 Feb 18
16 10-11
Children's Hospital Medical Center (CHMC) Correspondence, 1976
16 12
[LVAD] Case file, 1976
16 13
Texas Heart Institute (THI) Correspondence, 1976
16 14
[N01-HV-1-2060 Work Status], 1977 Mar 23
16 15
[Instrument Systems for Non-invasive Detection, Characterization and Quantification of Atherosclerotic Lesions], 1977
16 16-17
Cornell Dog Study [photograph], 1977-1978
16 18-19
[Dahl] S/R [Rats] Users Panel, 1979-1983
16 20-22
[Dahl S/R Rats -] Y01-HV-00031 - Interagency Agreement, 1979-1983
16 23
Program Plan, RFA NIH-NHLBI-82G-H: Mechanisms of Calcification of Prosthetic Materials in the Cardiovascular System, 1982
16 24-25
N01-HV-38043 - University of Wisconsin - [Contract file] [photographs, slides], 1983-1991
16 26
Research and Development Grants, 1985 Nov
16 27
["Clinical Ventricular Assist System Production, Support and Evaluation" - Source Selection Document/Funding], 1988
16 28
["Intraventricular Axial-Flow-Pump Artificial Heart"], 1988-1992
16 29
Retrospective Reliability Analysis of the Electrohydraulic Total Artificial Heart, 1989 Apr 27
16 30
[Novacor LVAS/Baxter], 1989-1991
16 31
NIH Site Visit [Presentation by the EHTAH Project Team, Artificial Heart Research Laboratory, University of Utah], 1990 Feb 21
16 32
Review of Activities to Develop a Thermal Ventricular Assist System TVAS, 1990 Jul 23
16 33
New England Research Institute - N01-HV-08111 [- "Data Coordinating Center for the Evaluation of Implantable Ventricular Assist Systems for Human Subjects with Chronic Refracting Heart Failure"], 1990-1994
16 34
Baxter-Novacor, 1991-1993
33 1
[Technical Data Package for the Electro-Hydraulic Total Artificial Heart (EHTAH) Volume VII of VII], 1993 Oct 1
16 35
Innovative Ventricular Assist System (IVAS) Program Plan, 1995 Oct 31
16 36
Tissue Engineering, Biometrics, and Medical Implant Science [Program Plan] [photographs], 1998 May 14