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National Library of Medicine

Finding Aid to the W. French Anderson Papers, 1977-1995

History of Medicine Division
Processed by Jim Labosier
Processing Completed November 2016
Encoded by Jim Labosier


Summary Information
Title: W. French Anderson Papers
Creator: Anderson, W. French, 1936-
Dates: 1977-1995
Extent: 9.59 linear feet (10 boxes)
Abstract:
Correspondence, reports, research data, meeting agendas and minutes, and protocols documenting Dr. W. French Anderson's pioneering application of gene therapy in a human subject.

Call number: MS C 620
Language: Collection materials primarily in English
Location: Materials stored onsite. History of Medicine Division. National Library of Medicine

Access Restrictions:

Collection is restricted. Portions of the collection are restricted according to HMD's Access to Health Information of Individuals policy. Contact the Reference Staff for information regarding access. For access to the policy and application form, please visit https://www.nlm.nih.gov/hmd/manuscripts/phi.pdf.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Anderson, W. French. W. French Anderson Papers. 1977-1995. Located in: Archives and Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 620.

Provenance:

Gift of W. French Anderson, Acc. 2002-010, Acc 2004-037.


101291466Finding Aid to the W. French Anderson Papers, 1977-1995History of Medicine Division. Archives and Modern Manuscripts Collection1.0History of Medicine Division, National Library of Medicine.
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Machine-readable finding aid encoded by Jim LabosierFinding aid is written in English

National Library of Medicine

Finding Aid to the W. French Anderson Papers, 1977-1995

History of Medicine Division
Processed by Jim Labosier
Processing Completed November 2016
Encoded by Jim Labosier

Descriptive Summary

Anderson, W. French, 1936-W. French Anderson Papers Dates: 1977-19959.59 linear feet (10 boxes)MS C 620Materials stored onsite. History of Medicine Division. National Library of MedicineCollection materials primarily in EnglishAbstract:Correspondence, reports, research data, meeting agendas and minutes, and protocols documenting Dr. W. French Anderson's pioneering application of gene therapy in a human subject.Provenance:

Gift of W. French Anderson, Acc. 2002-010, Acc 2004-037.

Access Restrictions:

Collection is restricted. Portions of the collection are restricted according to HMD's Access to Health Information of Individuals policy. Contact the Reference Staff for information regarding access. For access to the policy and application form, please visit https://www.nlm.nih.gov/hmd/manuscripts/phi.pdf.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Anderson, W. French. W. French Anderson Papers. 1977-1995. Located in: Archives and Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 620.

Biographical/Historical Note

William French Anderson was born in Tulsa, Oklahoma on December 31, 1936. He received both his undergraduate and medical degrees from Harvard, the latter in 1963. After an internship at Children's Hospital Medical Center in Boston and a post-doctoral fellowship at Harvard, Anderson began his 27-year career at NIH with a 2-year position through the USPHS surgeon service in 1965. From 1965 into 1968 he worked for Dr. Marshall Nirenberg in the National Heart Institute's (NHI) Biochemical Genetics Laboratory, where he became an integral member of Nirenberg's DNA-coding team.

From the very start of his medical training, Anderson's primary interest was to develop a means of healing by replacing faulty genes that caused a disease with normally functioning genes. In 1968 he became chief of NHI's newly-created Section of Human Biochemistry and began researching gene therapy exclusively. During this same period he also taught molecular genetics at George Washington University School of Medicine and was a faculty member of the NIH Graduate Program's Department of Genetics.

From then until the early 1980s, Anderson pursued gene repair using microinjection techniques. The results, however, proved unsatisfactory. By 1980 he had reached an impasse in his research and began exploring other medical fields, notably sports medicine.

His interest in gene therapy was revived when experimentation with gene replacement, notably by Richard C. Mulligan, demonstrated the effective use of a retrovirus as a genetic vector. Seizing upon the possibilities, Anderson determined that the most likely initial candidate for genetic transplantation would be adenosine deaminase (ADA), due to its relative simplicity. When deficient, this enzyme causes a human body's immune system to fail leading to severe combined immunodeficiency (SCID). Persons suffering from this condition rarely survive childhood and are vulnerable to nearly every pathogen in the environment.

Though experimentation with ADA in primate bone marrow proved only marginally encouraging, Anderson felt confident that the tests should be conducted in humans. Throughout 1986 and 1987 he began the groundwork to obtain approval for human ADA gene therapy from NIH, NIH's Recombinant DNA Advisory Committee (RAC), and the Food and Drug Administration (FDA).

By early 1989 Anderson, and partners Dr. Steven A. Rosenberg and Dr. Robert M. Blaese from NCI, had secured approval from NIH, the FDA, and RAC's Human Gene Therapy Subcommittee to conduct a genetic transfer experiment on 10 terminal human subjects whose treatments by all known methods had failed. The technique involved re-inserting a malignant melanoma patient's own modified tumor-infiltrating lymphocytes (TIL), which had been imbued with a distinctive marker. On May 22, 1989, Maurice Kuntz received the marker injection which Rosenberg called "the first time ever that a new gene has been introduced into a human." This successful experiment demonstrated that gene transfer in humans was safe.

Encouraged by the experiment's outcome, Anderson and his team sought approval to take the procedure a step further and initiate human gene therapy trials with an ADA/SCID patient. Shortly after receiving FDA's approval, Anderson replaced the defective ADA gene in 4-year-old Ashanthi DeSilva on September 14, 1990. The procedure was recognized as the first time a healthy gene had been infused into a human. In January, 1991, 9-year-old Cindy Cutshall was also treated. The treatments did not bring about total correction of SCID in either patient, but were therapeutically substantial enough that suppported by a regular medication routine the patients were able to enjoy relatively normal lives.

Although scientific consensus about the trial's success was mixed, the groundbreaking work by Anderson and his team in developing and demonstrating the efficacy of genetic transplantation was hailed internationally as the first steps in a new field of medical treatment. Because of this work Anderson has been called "The Father of Gene Therapy."

Anderson left the NIH in 1992 to accept a position as director of the Norris Comprehensive Cancer Center's Gene Therapy Laboratories (GTL) at USC's Keck School of Medicine, and as professor of biochemistry and pediatrics.


Correspondence, laboratory and patient research data, clinical trial proposal development and IRB review records, meetings and conferences files, presentations, and videotapes document French Anderson's groundbreaking work to develop procedures for and to perform the first therapeutic introduction of gene therapy in humans. The collection concentrates almost exclusively on Anderson's tenure at the Molecular Hematology Branch of the National Heart, Lung and Blood Institute and in collaboration with the National Cancer Institute. It covers only the period of his career from 1977 to 1995. It does not include his post-NIH career at the University of Southern California.

Series 1, Biographical Information (1988-1992) is a small and disparate set of folders devoted to high school and college class reunions and some documentation of the terms of Anderson's move from NIH to the University of Southern California in 1992.

Series 2, Human Gene Therapy (1977-1992) contains fairly comprehensive documentation of Anderson's efforts to develop an effective gene therapy protocol, particularly between 1984 and 1990 when he concentrated on the method of introducing genes with a retrovirus. It is divided into two main sections comprising information about his two major breakthroughs: demonstration of the efficacy of gene therapy protocols (Tumor-Infiltrating Lymphocytes) and introduction of a healthy gene into a human being to correct a malfunctioning gene (Adenosine Deaminase). Each section contains subsets of correspondence, meeting agendas and reports relating to the lengthy process of developing protocols and receiving approval, applications and descriptions of experimental drugs, and data produced.

Series 3, Activities Outside NHLBI (1979-1992) is comprised of Anderson's collected materials relating to teaching engagements, lectures given, and meetings and conferences attended that were not directly involved with his lab work. They range from meetings at other NIH institutes to international conferences.

Series 4, Writings (1984-1990) is a small set of articles co-authored by Anderson, some written by others. All are devoted to gene therapy theory and practice as seen in the results of animal testing, mostly concerned with use of the ADA enzyme.

Series 5, Audiovisual Materials (1985-1995) are exclusively videocassettes and are organized into subseries developed by Anderson. Tapes in the Gene Therapy-related Subjects subseries (1986-1995) are mostly segments of commercial broadcast programs which address the concept of gene therapy. The Anderson Lectures subseries (1986-1994) present a series of speeches given by Anderson himself describing the potential of gene therapy. Clips from News Programs subseries (1989-1990) documents reporting done by various national television programs and networks about Anderson's gene therapy experiments.

Index Terms

These terms are indexed in the National Library of Medicine's online catalog LocatorPlus. Researchers wishing to find related materials should search the catalog using these terms.

    MESH Subjects

    • Adenosine Deaminase
    • Clinical Trials as Topic
    • Drugs, Investigational
    • Genetic Therapy
    • Genetic Vectors
    • Lymphocytes, Tumor-Infiltrating
    • Retroviridae
    Personal Names

    • Cornetta, Kenneth
    • Cutshall, Cindy
    • DeSilva, Ashanthi
    Corporate Names

    • National Heart, Lung, and Blood Institute
    • United States. Food and Drug Administration

    Series Descriptions

    Series 1: Personal and Biographical Information, 1988-199211 Harvard Medical School - 25th reunion, 1988-199112 Central High School reunion, 198913 Clarification of post-government employment regulations relative to CRADA, 1992Born Digital Archive-It web archive, top results for "W. French Anderson" Google search conducted by HMD staff, as an effort to augment his physical personal papers collection., 2016 Dec. 2

    [view online]

    Series 2: Human Gene Therapy Research, 1977-1992 Tumor-Infiltrating Lymphocytes (TIL)/Marker Gene Correspondence 14 FDA, 1984-198815 Correspondence, 1988-198916 Correspondence, 198917 FDA review of protocol IND 3042, 1989 Protocols and Review Process 18 Bone marrow - protocols and data, 1986-198719 Animal protocols for baboons, cynomologous monkeys, and rhesus monkeys, 1987-1989110-14 Human gene therapy preclinical data summary - to Human Gene Therapy Subcommittee, 24 April 1987115 FDA duplicates, 1989116 SAR notes, April-November 1989117 N2/TIL, 7 August 1989118-19 FDA Adv. Comm [FDA advisory committee], 19 December 1988120 Human Gene Therapy Subcommittee - meeting, 31 July 1989 Data 121 Half life of TIL in circulating blood, c.1980s122-25 Southerns / probes / food / misc. molecular biology, 1985-198721-4 TIL notebooks, 1985-198925 CFU - Media Record I - SB 7D17, 1986-198826 Cornetta - old data, 1988-1989215 Ken Cornetta RAC mat., 23 November 198827 TIL notes, 1988-198928 Pre-Kuntz, 198929 Tests for FDA certification, 1989210 Certification of analysis - TIL, 1989211 Certificate of analysis - viral supernate and N2 viral supernate, 1989212 TIL protocol, 1988213 FDA-NCI audit, 1989214 Clin. Prot. - TIL, 1990 Investigational New Drugs (IND) 216-17 Study 86-C-183 - IND 1969 - The treatment of patients with advanced cancer using high dose recombinant interleukin-2 plus cyclophosphamide and TIL - clinical research project annual review, 1988-1989218-20 IND 2474 - N2 transduced TIL - original filing book II, 1987221-23 IND 2474 - N2 transduced TIL - original filing book I, 198831-3 IND 2474 - N2 transduced TIL - original filing book I, 198834-5 Murine monoclonal antibodies to tumor associated glycoprotein (TAG-72), 198836-8 IND 3042 - N2 transduced TIL - original filing - book I, 198839 IND 3042 for N2 transduced TIL cells, 1989310-11 IND 3042 - N2 transduced TIL, 1989312-14 IND 3042 - N2 transduced TIL - FDA duplicates, 1988-1989315-17 IND 3042 - N2 transduced TIL - summary, 1988-1989318-19 IND 3042 - N2 transduced TIL - amendments, 1988-198941 IND 3042 - N2 transduced TIL - amendments (cont'd), 1988-198942 IND 3042 - N2 transduced TIL - amendments, 1989-199043 Patent: TIL, 1989-1990 Forms 44 Forms, c.198945 TIL protocol checklists, c.198946 Clinical research project - forms, c.198947 Informed consent statement for HIV blood testing - form, c.1989 Related Material 48 "Grand Rounds - A Gene Transfer Experiment in Humans: One Year Later" - Clinical Center News, May 199049 Visit of Mrs. Arlene Holen, Associate Director for Human Resources, Veterans and Labor, OMB to NIH - itinerary, 25 August 1988 Adenosine Deaminase (ADA) Human Gene Therapy Correspondence 410 Note to Dr. Anderson from Ken Cornetta, 1990411-13 Correspondence, 1990-1991 Protocols and Review Process 414 Clin. protocol, 1985415 Transduction safety protocol, c.1989416 Articles submitted with human gene therapy protocol - list, c.1989417 Clin. prot - ADA, 1989418 Recombinant DNA Advisory Committee meeting - mailings, 6 October 1989419 ADA gene therapy protocol, 1990420-21 Recombinant DNA Advisory Committee meeting - mailings, 5 February 1990422-23 NCI IRB - ADA, February-March 1990424 NIH IBC - ADA, 7 March 1990425 NHLBI IRB - ADA, March-July 1990426 Submission of ADA Human Gene Therapy Clinical Protocol, 13 March 1990427 Protocol impact analysis, 23 March 1990428 Response to reviews of Human Gene Therapy Subcommittee, 29 March 1990429 Human Gene Therapy Subcommittee meeting - agenda, 30 March 1990430 Human Gene Therapy Subcommittee - meeting - mailing, 30 March 1990431 Review of human gene therapy protocol - Wivel, 25 April 1990432 Review of human gene therapy protocol - Blaese, 27 April-23 May 1990433 Secondary review of clinical protocol for human gene therapy - by James F. Childress, 16 May 1990434 Human Gene Therapy Subcommittee - meeting - mailings, 1 June 1990435-36 Human Gene Therapy Subcommittee - meeting, 1 June 1990437-38 Clinical research project - Treatment of SCID due to ADA deficiency with autologous lymphocytes transduced with a human ADA gene, 6 July 1990439 Response to: Points to consider in the design and submission of protocols for the transfer of recombinant DNA into the genome of human subjects, 6 July 1990440 Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency (ADA) with autologous lymphocytes transduced with a human ADA gene - Clinical Center hospital impact statement, 6 July 1990441 Human Gene Therapy Subcommittee - meetings - mailings, 30-31 July 199051 Human Gene Therapy Subcommittee - meetings - mailings (cont'd), 30-31 July 199052 HGTS and RAC meetings - additional materials, 199053 FDA's questions, 199054 Copies of tumor letter for WFA, RBB, SAR, 199055-6 Amendment to ADA human gene therapy protocol - 90-C-195, 199257 Gene therapy protocols - book #1 [photocopy], 199158 Gene therapy protocols - book #3 [photocopy], 1992-199359 Gene therapy protocols - book #4 [photocopy], 1993 Data - research and experimental 510 ADA starch protocols and papers [photographs], 1985-1986511 Monkey data / safety exps, 1985-1987512 Long-term follow-up - yearly examination criteria, c.1988513 Monkey data, 1986-1991514-16 Cellulose acetate ADA analysis, 1987-1990517 FA freezer, 1990-1992518-19 FA lab book, c.1991520 Tumor in LNL6 safety mouse, 1 March 1990521 Hematology report, 6 March 1990522 Blood chemistry report, 6 March 1990523 List of samples for cellulose acetate ADA assay, 24 March 1990524 DeSilva proliferation summary, 5 September-20 December 1990525 Certificate of analysis - transduced T cells , 14 September 1990526 Certificate of analysis - vector supernate, 14 September 1990527 TNF, January-26 April 1991528 Certificate of analysis - LASN vector supernate, 18 January 1991529 Using NPTII Ab to detect gene transfer by retrovirus - and other data, 28 February-7 May 1991530 ADA, 28 May 1991531 In vitro proliferation results - proliferation assay - for DeSilva and Cutshall, June-August 1991532 Research data, 23 July-23 August 1991 Investigational New Drugs (IND) 533 IND 3624 - Human adenosine deaminase gene transduced autologous T. Lymphocytes, 1990534 IND 3624 - Autologous lymphocytes transduced with human adenine deaminase gene (retrovirus vector LASN) cultivated with IL-2 (cetus) and ORT3 (ortho), 1991535 Human adenosine deaminase gene transduced autologous T-lymphocytes (ADA-transduced T lymphocytes) - annual report to FDA, 1991 Forms 536 Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency (ADA) with autologous lymphocytes transduced with a human ADA gene - patient consent form, c.1990537 Children's assent form [for ADA-SCID protocol], c.1990538 GTI supernatant request form, 1990 Scheduling and Procedures 539 Information for ADA-SCID gene therapy patients - drafts, 1990540 Selection of ADA-SCID patients, 1990541 DeSilva patient name labels, 1990542 DeSilva schedule, 1990543 Cindy Cutshall - schedule, 1990544 Rainbow patients are first candidates for new gene transplants - news release, 2 August 1990545 Schedule for A.D. and her family, 3-7 September 1990546 Dr. Anderson [photographs], 13-14 September 1990 Series 3: Meetings, Conferences, Workshops, and Talks, 1979-1992548 Gene Therapy Seminar, NIH; Ethics Lecture, NIH, 2 October 1978; 2 April 1979547 Second Symposium on Development of Iron Chelators for Clinical Use, NIH, 15 February 1980549 Minority Biomedical Support Symposium, Atlanta, GA, 9-10 April 1980550 Peripatetic Club, Boston, MA, 11-12 April 1980551 Second International Symposium on RNA, Peking, China, 20 April-3 May 1980552 Meeting with Dr. Robert J. Desnick, Mt. Sinai School of Medicine, NY, 22 May 1980553 Second International Congress on Cell Biology, West Berlin, West Germany, 31 August-5 September 1980554 Expression of Cloned Genes after Microinjection into Mammalian Cells, Georgetown University Seminar, 19 September 1980555 American Society of Human Genetics, New York, NY, 24-27 September 1980556 Athletic Injuries, Harvard Medical School, 12-19 October 1980557 Pediatric Grand Rounds, NICHD, 13 November 1980558 Carnegie Institute, Baltimore, 17 November 1980559 Workshop on Mammalian Vectors, Cold Spring Harbor, NY, 11-13 December 1980560 The International Implications of Biotechnology, Georgetown University, Washington, D.C., 6 February 1986561 "Prospects for Human Gene Therapy" - Medical Grand Rounds, M.D. Anderson Hospital, Houston, TX, 7 February 1986562 Charles W. Lacaillade Alumni Program for Health Professions, St. John's University, NY, 4 March 1986563 "Prospects for human gene therapy" - talk at Yale Human Genetics Department, New Haven, CT, 11 March 1986564 Scientist Institute for Public Information, Stanford University, 12-14 February 1986565 Review Dr. Eli Gilboa research procedures, Princeton University, 13 March 1986566 Peripatetic Club, Montreal, Canada, 14-15 March 198661 Non-human primate bone marrow transplantation, Memorial Sloan-Kettering Cancer Center, NY, 19 March 198662 Seminar - Alan Schechter's Lab, NIH, 27 March 198663 Washington Area Ethics Seminar, Georgetown University, Washington, D.C., 8 April 198664 Immune Deficiency Foundation Board of Trustees Meeting, Baltimore, MD, 12 April 198665 Recent Advances in Bone Marrow Transplantation, UCLA Symposia on Molecular and Cellular Biology, Keystone, CO, 13-17 April 198666 Wall-Copeland Memorial Lecture, Children's Hospital National Medical Center, Washington, D.C., 18 April 198667 New York Avenue Presbyterian Church talk, New York, NY, 27 April 198668 Technology and Culture Seminar, MIT, Boston, 28 April 198669 Human Genetics Course, Institute for Medical Research, Camden, NJ, 1 May 1986610 American Association for Clinical Investigation, Washington, D.C., 2-5 May 1986611 Cooley's Anemia Grants Review Meeting, Columbia University, NY, 19 May 1986612 Molecular Biology of Homo Sapiens, Cold Spring Harbor, NY, 28 May-4 June 1986613 Prep rehearsal for 6/3/86 site visit to Memorial Sloan-Kettering Cancer Center, NY, 29 May 1986614 Nature: New Technology in Biotechnology Conference, London, 18-20 June 1986615 Non-human primate bone marrow transplantation, Memorial Sloan-Kettering Cancer Center, NY, 6 August 1986616 Grand Rounds, Clinical Center, NIH, 3 September 1986617 Gene Therapy, Holy Cross Hospital, Silver Spring, MD, 9 September 1986618 Nature Conference: Exploring and Exploiting the Human Genome, Boston, 15-17 September 1986619 Mayer Lecture, Wellesley College, MA, 18 September 1986620 Fourth Decennial Review Conference on Tissue Culture, Hershey, PA, 22-26 September 1986621 The Prospect of Gene Therapy, Albert Einstein College of Medicine, Bronx, NY, 5 January 1987622 District of Columbia Academy of Veterinary Medicine, Arlington, VA, 8 January 1987623 American Association for the Advancement of Science Annual Meeting, Chicago, 14 February 1987624 Peripatetic Club Meeting, Boston, 13-14 March 1987625 Medical Scientist Lecture Series, U.C. Irvine, 29-31 March 1987626 Genetic Engineering: Implications and Ethics Symposium, University of Wisconsin, Stevens Point, 2 April 1987627 Institute for Theological Encounter with Science and Technology, Washington, D.C., 10-12 April 1987628 Hilldale Lectures, University of Wisconsin, 15 April 1987629 NIH Day, NIH, 4 May 1987630-31 Fourth International Congress on Inborn Errors of Metabolism, Sendai, Japan, 27-30 May 1987632 International Symposium on Fetal Therapy, Dearborn, MN, 6 June 1987633 Conference on Gene-Splicing, Eastern College, St. Davids, PA, 27-30 June 1987634 Workshop on the Molecular Biology of Mental Restoration, NIH, 1-2 September 1987635 Society of Pediatric Pathology, Washington, D.C., 18 September 1987636 Current Iron Chelator Study Compound, NIH, 22 September 1987637 Hepatitis B Viruses, Cold Spring Harbor, NY, 28 September-1 October 1987638 Mid-American Molecular Biology Colloquium, Afton, OK, 4-7 October 1987639 National Heart, Lung and Blood Advisory Council Meeting, NIH, 22 October 1987640 Senate Staff Meeting, Dirksen Senate Office Building, Washington, D.C., 23 October 1987641 Scientific Advisory Council, Children's Hospital Medical Center, Cincinnati, 30 November 1987642 Immunology Council's Annual Symposium, Johns Hopkins University, 2 November 1987643 Molecular Biology of Hemopoiesis, Rye Brook, NY, 6-7 November 1987644 American Association of Pathologists, Washington, D.C., 8 November 1987645 American Society of Hematology, Washingnton, D.C., 5-8 December 1987646 Foundation for Advanced Education in the Science, Inc., Bethesda, 7 January 1988647 National Conference of Catholic Bishops, Washington, D.C., 22-24 January 1988648 Dr. Parry - Medical Genetics Elective, NIH, 29 January 1988649 Gene Therapy in Animals, UCLA, 6-12 February 1988650 Medical College of Wisconsin, 13 February 1988651 American College of Physicians, New York, NY, 3-5 March 1988652 Peripatetic Club Meeting, NIH, 25-26 March 1988653 Annual Biology Gatlinburg Conference, Oak Ridge National Laboratory, TN, 11-14 April 1988654 Programs of Excellence in Molecular Biology, NIH, 1-3 June 1988; 19-20 April 1989655 Association of American Physicians, Washington, D.C., 29 April-2 May 1988656 Immune Deficiency Foundation Symposium, Washington, D.C., 5 May 1988657 RNA Tumor Viruses, Cold Spring Harbor, NY, 17-22 May 1988658 Gene Therapy: A Progress Report - Clinical Center Grand Rounds, 25 May 1988659 Food and Drug Administration, Center for Drug Evaluation and Research Seminar, Bethesda, 1 June 1988660 Biotechnology Seminar Series - Prospects for Human Gene Therapy, 7 June 1988661 Bionet Training Seminar, Mountain View, CA, 15-17 July 1988662 Protocol Meeting on Iron Chelator Study, NIH, 17 August 1987663 Laboratory of Tumor Cell Biology Annual Meeting, Bethesda, 22-26 August 1988664 Intelligenetics/Bionet Users Group Meeting III, NIH, 25 August 1988665 Sixth Conference on Hemoglobin Switching, Airlie House, VA, 25-28 September 1988666 NHLBI Intramural Research Day, 21 October 1988667 American Association of Pathologists, Bethesda, 2 November 1988668 Minority Access to Research Careers Scholars Conference, 2-5 November 1988669 Children's Hospital Medical Center, Cincinnati, OH, 10-12 November 198871 Molecular Mechanisms and Strategies, NIH, 30 November-1 December, 198872 NIH Science Writers Guild - "Who Decides When Scientific Findings Become Public Information: Scientists or Reporters?", NIH, 6 December 198873 AIDS-Branch Seminar, Bethesda, 13 December, 198874 Genetic Therapy, Inc., Workshop, Rockville, MD, 18 January 198975 Washington Journalism Center's Conference for Journalists on Health Issues, Washington, D.C., 25 January 198976 S/L Meeting, Nutley, NJ, 9 February 198977 Biomedical Ethics Advisory Committee, Washington, D.C., 17-18 February 198978 Symposium on Scientific Journals, Chicago, 9 May 198979 International ABC Biotechnology Meeting, Washington, D.C., 30 March 1989710 RNA Tumor Viruses, Cold Spring Harbor, NY, 24-28 May 1989711 Hastings Center 20th Anniversary Meeting, Briarcliff Manor, NY, 9-10 June 1989712 American Association for the Advancement of Science Committee on Scientific Freedom and Responsibility, Washington, D.C., 21 June 1989713 Annual Meeting of the Laboratory of Tumor Cell Biology, Washington, D.C., 20-26 August 1989714 American Academy of Medicine of the District of Columbia, Cosmos Club, Washington, D.C., 4 October 1989715 Walter Reed Retrovirus Research Group, Rockville, 13 October 1989716 15th Annual Frederick Stohlman, Jr. Memorial Symposium, Boston, 18 October 1989717 American Association of Pathologists, Bethesda, 22 October 1989718 Genes, Genomes and Genetics, Coriell Institute for Medical Research, Cherry Hill, NJ, 26 October 1989719 International Federation of Catholic Universities Research Committee of International Study, Group on Bioethics, Georgetown University, 27-28 October 1989720 Conference on Gene Manipulation and Human Disease, Boston, 9-10 November 1989721 NHLBI AIDS Ad Hoc Working Group, NIH, 20 November 1989722 Thrombolysis, NIH, 29-30 November 1989723 St. Jude's Hospital, Memphis, TN , 7 December 1989724 NIH Consensus Development Conference - consensus statement, 21-23 May 1990 Series 4: Writings, 1984-1990 By Others 81 "Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase" (1988), c.198882 "Pegademase", 199083 "Expression of human adenosine deaminase in mice transplanted with hemopoietic stem cells infected with amphotropic retroviruses", 199084 Federal Register - DHS articles (1990), c.1990 By Anderson 85 Preparation of adenosine deaminase (ADA) - corrected T cells for human gene therapy - abstract - Anderson a co-author, c.198486 "Prospects for human gene therapy" - Anderson, 198487 Gene expression in mice after high efficiency retroviral-mediated gene transfer" - Anderson a co-author, 198588 "Expression of human adenosine deaminase in nonhuman primates after retrovirus mediated gene transfer" - Anderson a co-author, 198789 Understanding gene transfer therapy - Pamphlet - drafts, 1988-1989810 "In vivo expression and survival of gene-modified rhesus T-lymphocytes" - draft, Anderson co-author, 1990 Series 5: Audiovisual Materials, 1985-1995 Gene Therapy 9 "Genetic Gamble" - NOVA, WGBH [vhs videocassette], 19859 N2/TIL skit [vhs videocassette], October 19889 Patient Interview - Maurice Kuntz [vhs videocassette] 13:55, c.19899 "Gene Therapy" (Cindy Cutshall/Culver) - tapes 1, 2, 3 [vhs videocassette] 44:20, 19909 "The Cline Affair" - BBC Antenna Horizon [vhs videocassette], 6 July 19899 NIH/NHLBI - B-Roll Dr. W. French Anderson [vhs videocassette] 7:57, 27 July 19909 "Gene Therapy" (DeSilva informed consent) [vhs videocassette} 100:00, 14 September 19909 BioEast /91 - 9114 Human Gene Therapy: Clinical IND and Practical Considerations [vhs videocassette], 19919 "Women's Health Special" - Physician's Journal Update [vhs videocassette] 7:00, 19919 Gene Therapy Patient Recognition Program: 1st Gene Therapy anniversary Party, tapes 1-4 [vhs videocassette] 56:30, 14 September 19919 One Hundredth Commencement Program, University of Oklahoma - honorary degree recipients [vhs videocassette], 9 May 19929 The Secret of Life - Tae Kwon Do sequence [vhs videocassette] 60:00, 27 July 19929 "Gene Therapy" - Beyond 2000, series 9, show 29 [vhs videocassette], 19939 "Genetic Screening" - Beyond 2000, series 9, show 30 [vhs videocassette], 19939 "Children by Design" - The Secret of Life, PBS, David Suzuki [vhs videocassette], 19939 The Secret of Life - diseases - race car out footage [vhs videocassette], 9 July 19939 BioEast - G09 Challenges in Human Gene Therapy - PBS special [vhs videocassette], 19949 Vision: celebrating 25 years of research [vhs videocassette] 13:00, 19949 48 Hours, Marked For Life - Dan Rather [vhs videocassette], 30 March 19949 Oklahoma - Oklahoma Heritage Association [vhs videocassette], 19959 "In Our Lifetime" - USC final master [vhs videocassette], 19959 Dr. French Anderson, Alpern Ad Hoc - USC raw footage [vhs videocassette], 1995 W. French Anderson Lectures 9 "Prospects for Human Gene Therapy" - FDA Seminar [Umatic videocassette] 60:00, 18 February 19869 "Human Gene Therapy" - 1991 Cartwright Lecture [2 vhs videocassettes] 72:00, 19919 "Genetic Engineering and Humanness" - Washington Cathedral [vhs videocassette] 67:00, 30 September 19919 "Gene Therapy" - PHS Technology Transfer Forum, Lister Hill Auditorium [vhs videocassette] 45:00, 14 November 19919 "Human Gene Therapy" - G. Burroughs Mider Lecture [vhs videocassette] 87:41, 19929 Molecular Miracles: Human Gene Therapy and the Future of Modern Medicine [vhs videocassette] 47:00, 19939 "Gene Therapy in the Treatment of Cancer" - Advancements in Cancer Therapy: an oncology video update, volume 3 [vhs videocassette] 30:00, 7 October 19939 AAMC Plenary Session [2 vhs videocassettes], 31 October 1994 Clips From News Programs 9 Newsclips 1989-1990 - USC School of Medicine [videocassette], 1989-19909 "Gene Therapy" - CBS News, 6/25/1989; CBS News, 1/1/1990 [vhs videocassette], 25 June 1989; 1 January 19909 "Human Gene Transfer" - NBC National News [vhs videocassette], 22 May 19899 1) "Genetic Transfer at NIH" - WRC-TV NBC Nightly News, 5/22/89; 2) WUSA-TV Eyewitness News, 5/23/89; 3) CNN Newswatch, 5/22/89 [vhs videocassette] 6:10, 22-23 May 19899 1) "Bubble Boy-Cancer Therapy" - CNN TV, 7/30/90; 2) "Human Genome Therapy" CBS TV and ABC TV, 7/31/90 [vhs videocassette], 30-31 July 19909 Dr. Melvin Burger on Immune Disorders - Local News (Cleveland) [vhs videocassette], 2 August 19909 1) "Gene Therapy" - CBS Evening News, 9/13/90; 2) WUSA, 9/13/90; 3) Today, 9/14/90; 4) CBS This Morning, 9/14/90 [vhs videocassette], 13-14 September 19909 1) CNN Morning News; 2) CNN News from Medicine; 3) Ch 9 Eyewitness News; 4) Ch 4 NBC Nightly News; 5) CBS Evening News; 6) McNeil-Lehrer News; 7) Ch 7 ABC News [vhs videocassette], 14 September 19909 "Gene Therapy" - McNeil-Lehrer News Hour [vhs videocassette] 11:30, 14 November 1990

    Collection Scope and Content Note

    Correspondence, laboratory and patient research data, clinical trial proposal development and IRB review records, meetings and conferences files, presentations, and videotapes document French Anderson's groundbreaking work to develop procedures for and to perform the first therapeutic introduction of gene therapy in humans. The collection concentrates almost exclusively on Anderson's tenure at the Molecular Hematology Branch of the National Heart, Lung and Blood Institute and in collaboration with the National Cancer Institute. It covers only the period of his career from 1977 to 1995. It does not include his post-NIH career at the University of Southern California.

    Series 1, Biographical Information (1988-1992) is a small and disparate set of folders devoted to high school and college class reunions and some documentation of the terms of Anderson's move from NIH to the University of Southern California in 1992.

    Series 2, Human Gene Therapy (1977-1992) contains fairly comprehensive documentation of Anderson's efforts to develop an effective gene therapy protocol, particularly between 1984 and 1990 when he concentrated on the method of introducing genes with a retrovirus. It is divided into two main sections comprising information about his two major breakthroughs: demonstration of the efficacy of gene therapy protocols (Tumor-Infiltrating Lymphocytes) and introduction of a healthy gene into a human being to correct a malfunctioning gene (Adenosine Deaminase). Each section contains subsets of correspondence, meeting agendas and reports relating to the lengthy process of developing protocols and receiving approval, applications and descriptions of experimental drugs, and data produced.

    Series 3, Activities Outside NHLBI (1979-1992) is comprised of Anderson's collected materials relating to teaching engagements, lectures given, and meetings and conferences attended that were not directly involved with his lab work. They range from meetings at other NIH institutes to international conferences.

    Series 4, Writings (1984-1990) is a small set of articles co-authored by Anderson, some written by others. All are devoted to gene therapy theory and practice as seen in the results of animal testing, mostly concerned with use of the ADA enzyme.

    Series 5, Audiovisual Materials (1985-1995) are exclusively videocassettes and are organized into subseries developed by Anderson. Tapes in the Gene Therapy-related Subjects subseries (1986-1995) are mostly segments of commercial broadcast programs which address the concept of gene therapy. The Anderson Lectures subseries (1986-1994) present a series of speeches given by Anderson himself describing the potential of gene therapy. Clips from News Programs subseries (1989-1990) documents reporting done by various national television programs and networks about Anderson's gene therapy experiments.

    Contents List
    Box | Folder Title
     
    Series 1: Personal and Biographical Information, 1988-1992 [series]:
    1 1
    Harvard Medical School - 25th reunion, 1988-1991
    1 2
    Central High School reunion, 1989
    1 3
    Clarification of post-government employment regulations relative to CRADA, 1992
    Born Digital
    Archive-It web archive, top results for "W. French Anderson" Google search conducted by HMD staff, as an effort to augment his physical personal papers collection., 2016 Dec. 2 [view online]
     
    Series 2: Human Gene Therapy Research, 1977-1992 [series]:
     
    Tumor-Infiltrating Lymphocytes (TIL)/Marker Gene [subseries]:
     
    Correspondence [subseries]:
    1 4
    FDA, 1984-1988
    1 5
    Correspondence, 1988-1989
    1 6
    Correspondence, 1989
    1 7
    FDA review of protocol IND 3042, 1989
     
    Protocols and Review Process [subseries]:
    1 8
    Bone marrow - protocols and data, 1986-1987
    1 9
    Animal protocols for baboons, cynomologous monkeys, and rhesus monkeys, 1987-1989
    1 10-14
    Human gene therapy preclinical data summary - to Human Gene Therapy Subcommittee, 24 April 1987
    1 15
    FDA duplicates, 1989
    1 16
    SAR notes, April-November 1989
    1 17
    N2/TIL, 7 August 1989
    1 18-19
    FDA Adv. Comm [FDA advisory committee], 19 December 1988
    1 20
    Human Gene Therapy Subcommittee - meeting, 31 July 1989
     
    Data [subseries]:
    1 21
    Half life of TIL in circulating blood, c.1980s
    1 22-25
    Southerns / probes / food / misc. molecular biology, 1985-1987
    2 1-4
    TIL notebooks, 1985-1989
    2 5
    CFU - Media Record I - SB 7D17, 1986-1988
    2 6
    Cornetta - old data, 1988-1989
    2 15
    Ken Cornetta RAC mat., 23 November 1988
    2 7
    TIL notes, 1988-1989
    2 8
    Pre-Kuntz, 1989
    2 9
    Tests for FDA certification, 1989
    2 10
    Certification of analysis - TIL, 1989
    2 11
    Certificate of analysis - viral supernate and N2 viral supernate, 1989
    2 12
    TIL protocol, 1988
    2 13
    FDA-NCI audit, 1989
    2 14
    Clin. Prot. - TIL, 1990
     
    Investigational New Drugs (IND) [subseries]:
    2 16-17
    Study 86-C-183 - IND 1969 - The treatment of patients with advanced cancer using high dose recombinant interleukin-2 plus cyclophosphamide and TIL - clinical research project annual review, 1988-1989
    2 18-20
    IND 2474 - N2 transduced TIL - original filing book II, 1987
    2 21-23
    IND 2474 - N2 transduced TIL - original filing book I, 1988
    3 1-3
    IND 2474 - N2 transduced TIL - original filing book I, 1988
    3 4-5
    Murine monoclonal antibodies to tumor associated glycoprotein (TAG-72), 1988
    3 6-8
    IND 3042 - N2 transduced TIL - original filing - book I, 1988
    3 9
    IND 3042 for N2 transduced TIL cells, 1989
    3 10-11
    IND 3042 - N2 transduced TIL, 1989
    3 12-14
    IND 3042 - N2 transduced TIL - FDA duplicates, 1988-1989
    3 15-17
    IND 3042 - N2 transduced TIL - summary, 1988-1989
    3 18-19
    IND 3042 - N2 transduced TIL - amendments, 1988-1989
    4 1
    IND 3042 - N2 transduced TIL - amendments (cont'd), 1988-1989
    4 2
    IND 3042 - N2 transduced TIL - amendments, 1989-1990
    4 3
    Patent: TIL, 1989-1990
     
    Forms [subseries]:
    4 4
    Forms, c.1989
    4 5
    TIL protocol checklists, c.1989
    4 6
    Clinical research project - forms, c.1989
    4 7
    Informed consent statement for HIV blood testing - form, c.1989
     
    Related Material [subseries]:
    4 8
    "Grand Rounds - A Gene Transfer Experiment in Humans: One Year Later" - Clinical Center News, May 1990
    4 9
    Visit of Mrs. Arlene Holen, Associate Director for Human Resources, Veterans and Labor, OMB to NIH - itinerary, 25 August 1988
     
    Adenosine Deaminase (ADA) Human Gene Therapy [subseries]:
     
    Correspondence [subseries]:
    4 10
    Note to Dr. Anderson from Ken Cornetta, 1990
    4 11-13
    Correspondence, 1990-1991
     
    Protocols and Review Process [subseries]:
    4 14
    Clin. protocol, 1985
    4 15
    Transduction safety protocol, c.1989
    4 16
    Articles submitted with human gene therapy protocol - list, c.1989
    4 17
    Clin. prot - ADA, 1989
    4 18
    Recombinant DNA Advisory Committee meeting - mailings, 6 October 1989
    4 19
    ADA gene therapy protocol, 1990
    4 20-21
    Recombinant DNA Advisory Committee meeting - mailings, 5 February 1990
    4 22-23
    NCI IRB - ADA, February-March 1990
    4 24
    NIH IBC - ADA, 7 March 1990
    4 25
    NHLBI IRB - ADA, March-July 1990
    4 26
    Submission of ADA Human Gene Therapy Clinical Protocol, 13 March 1990
    4 27
    Protocol impact analysis, 23 March 1990
    4 28
    Response to reviews of Human Gene Therapy Subcommittee, 29 March 1990
    4 29
    Human Gene Therapy Subcommittee meeting - agenda, 30 March 1990
    4 30
    Human Gene Therapy Subcommittee - meeting - mailing, 30 March 1990
    4 31
    Review of human gene therapy protocol - Wivel, 25 April 1990
    4 32
    Review of human gene therapy protocol - Blaese, 27 April-23 May 1990
    4 33
    Secondary review of clinical protocol for human gene therapy - by James F. Childress, 16 May 1990
    4 34
    Human Gene Therapy Subcommittee - meeting - mailings, 1 June 1990
    4 35-36
    Human Gene Therapy Subcommittee - meeting, 1 June 1990
    4 37-38
    Clinical research project - Treatment of SCID due to ADA deficiency with autologous lymphocytes transduced with a human ADA gene, 6 July 1990
    4 39
    Response to: Points to consider in the design and submission of protocols for the transfer of recombinant DNA into the genome of human subjects, 6 July 1990
    4 40
    Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency (ADA) with autologous lymphocytes transduced with a human ADA gene - Clinical Center hospital impact statement, 6 July 1990
    4 41
    Human Gene Therapy Subcommittee - meetings - mailings, 30-31 July 1990
    5 1
    Human Gene Therapy Subcommittee - meetings - mailings (cont'd), 30-31 July 1990
    5 2
    HGTS and RAC meetings - additional materials, 1990
    5 3
    FDA's questions, 1990
    5 4
    Copies of tumor letter for WFA, RBB, SAR, 1990
    5 5-6
    Amendment to ADA human gene therapy protocol - 90-C-195, 1992
    5 7
    Gene therapy protocols - book #1 [photocopy], 1991
    5 8
    Gene therapy protocols - book #3 [photocopy], 1992-1993
    5 9
    Gene therapy protocols - book #4 [photocopy], 1993
     
    Data - research and experimental [subseries]:
    5 10
    ADA starch protocols and papers [photographs], 1985-1986
    5 11
    Monkey data / safety exps, 1985-1987
    5 12
    Long-term follow-up - yearly examination criteria, c.1988
    5 13
    Monkey data, 1986-1991
    5 14-16
    Cellulose acetate ADA analysis, 1987-1990
    5 17
    FA freezer, 1990-1992
    5 18-19
    FA lab book, c.1991
    5 20
    Tumor in LNL6 safety mouse, 1 March 1990
    5 21
    Hematology report, 6 March 1990
    5 22
    Blood chemistry report, 6 March 1990
    5 23
    List of samples for cellulose acetate ADA assay, 24 March 1990
    5 24
    DeSilva proliferation summary, 5 September-20 December 1990
    5 25
    Certificate of analysis - transduced T cells , 14 September 1990
    5 26
    Certificate of analysis - vector supernate, 14 September 1990
    5 27
    TNF, January-26 April 1991
    5 28
    Certificate of analysis - LASN vector supernate, 18 January 1991
    5 29
    Using NPTII Ab to detect gene transfer by retrovirus - and other data, 28 February-7 May 1991
    5 30
    ADA, 28 May 1991
    5 31
    In vitro proliferation results - proliferation assay - for DeSilva and Cutshall, June-August 1991
    5 32
    Research data, 23 July-23 August 1991
     
    Investigational New Drugs (IND) [subseries]:
    5 33
    IND 3624 - Human adenosine deaminase gene transduced autologous T. Lymphocytes, 1990
    5 34
    IND 3624 - Autologous lymphocytes transduced with human adenine deaminase gene (retrovirus vector LASN) cultivated with IL-2 (cetus) and ORT3 (ortho), 1991
    5 35
    Human adenosine deaminase gene transduced autologous T-lymphocytes (ADA-transduced T lymphocytes) - annual report to FDA, 1991
     
    Forms [subseries]:
    5 36
    Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency (ADA) with autologous lymphocytes transduced with a human ADA gene - patient consent form, c.1990
    5 37
    Children's assent form [for ADA-SCID protocol], c.1990
    5 38
    GTI supernatant request form, 1990
     
    Scheduling and Procedures [subseries]:
    5 39
    Information for ADA-SCID gene therapy patients - drafts, 1990
    5 40
    Selection of ADA-SCID patients, 1990
    5 41
    DeSilva patient name labels, 1990
    5 42
    DeSilva schedule, 1990
    5 43
    Cindy Cutshall - schedule, 1990
    5 44
    Rainbow patients are first candidates for new gene transplants - news release, 2 August 1990
    5 45
    Schedule for A.D. and her family, 3-7 September 1990
    5 46
    Dr. Anderson [photographs], 13-14 September 1990
     
    Series 3: Meetings, Conferences, Workshops, and Talks, 1979-1992 [series]:
    5 48
    Gene Therapy Seminar, NIH; Ethics Lecture, NIH, 2 October 1978; 2 April 1979
    5 47
    Second Symposium on Development of Iron Chelators for Clinical Use, NIH, 15 February 1980
    5 49
    Minority Biomedical Support Symposium, Atlanta, GA, 9-10 April 1980
    5 50
    Peripatetic Club, Boston, MA, 11-12 April 1980
    5 51
    Second International Symposium on RNA, Peking, China, 20 April-3 May 1980
    5 52
    Meeting with Dr. Robert J. Desnick, Mt. Sinai School of Medicine, NY, 22 May 1980
    5 53
    Second International Congress on Cell Biology, West Berlin, West Germany, 31 August-5 September 1980
    5 54
    Expression of Cloned Genes after Microinjection into Mammalian Cells, Georgetown University Seminar, 19 September 1980
    5 55
    American Society of Human Genetics, New York, NY, 24-27 September 1980
    5 56
    Athletic Injuries, Harvard Medical School, 12-19 October 1980
    5 57
    Pediatric Grand Rounds, NICHD, 13 November 1980
    5 58
    Carnegie Institute, Baltimore, 17 November 1980
    5 59
    Workshop on Mammalian Vectors, Cold Spring Harbor, NY, 11-13 December 1980
    5 60
    The International Implications of Biotechnology, Georgetown University, Washington, D.C., 6 February 1986
    5 61
    "Prospects for Human Gene Therapy" - Medical Grand Rounds, M.D. Anderson Hospital, Houston, TX, 7 February 1986
    5 62
    Charles W. Lacaillade Alumni Program for Health Professions, St. John's University, NY, 4 March 1986
    5 63
    "Prospects for human gene therapy" - talk at Yale Human Genetics Department, New Haven, CT, 11 March 1986
    5 64
    Scientist Institute for Public Information, Stanford University, 12-14 February 1986
    5 65
    Review Dr. Eli Gilboa research procedures, Princeton University, 13 March 1986
    5 66
    Peripatetic Club, Montreal, Canada, 14-15 March 1986
    6 1
    Non-human primate bone marrow transplantation, Memorial Sloan-Kettering Cancer Center, NY, 19 March 1986
    6 2
    Seminar - Alan Schechter's Lab, NIH, 27 March 1986
    6 3
    Washington Area Ethics Seminar, Georgetown University, Washington, D.C., 8 April 1986
    6 4
    Immune Deficiency Foundation Board of Trustees Meeting, Baltimore, MD, 12 April 1986
    6 5
    Recent Advances in Bone Marrow Transplantation, UCLA Symposia on Molecular and Cellular Biology, Keystone, CO, 13-17 April 1986
    6 6
    Wall-Copeland Memorial Lecture, Children's Hospital National Medical Center, Washington, D.C., 18 April 1986
    6 7
    New York Avenue Presbyterian Church talk, New York, NY, 27 April 1986
    6 8
    Technology and Culture Seminar, MIT, Boston, 28 April 1986
    6 9
    Human Genetics Course, Institute for Medical Research, Camden, NJ, 1 May 1986
    6 10
    American Association for Clinical Investigation, Washington, D.C., 2-5 May 1986
    6 11
    Cooley's Anemia Grants Review Meeting, Columbia University, NY, 19 May 1986
    6 12
    Molecular Biology of Homo Sapiens, Cold Spring Harbor, NY, 28 May-4 June 1986
    6 13
    Prep rehearsal for 6/3/86 site visit to Memorial Sloan-Kettering Cancer Center, NY, 29 May 1986
    6 14
    Nature: New Technology in Biotechnology Conference, London, 18-20 June 1986
    6 15
    Non-human primate bone marrow transplantation, Memorial Sloan-Kettering Cancer Center, NY, 6 August 1986
    6 16
    Grand Rounds, Clinical Center, NIH, 3 September 1986
    6 17
    Gene Therapy, Holy Cross Hospital, Silver Spring, MD, 9 September 1986
    6 18
    Nature Conference: Exploring and Exploiting the Human Genome, Boston, 15-17 September 1986
    6 19
    Mayer Lecture, Wellesley College, MA, 18 September 1986
    6 20
    Fourth Decennial Review Conference on Tissue Culture, Hershey, PA, 22-26 September 1986
    6 21
    The Prospect of Gene Therapy, Albert Einstein College of Medicine, Bronx, NY, 5 January 1987
    6 22
    District of Columbia Academy of Veterinary Medicine, Arlington, VA, 8 January 1987
    6 23
    American Association for the Advancement of Science Annual Meeting, Chicago, 14 February 1987
    6 24
    Peripatetic Club Meeting, Boston, 13-14 March 1987
    6 25
    Medical Scientist Lecture Series, U.C. Irvine, 29-31 March 1987
    6 26
    Genetic Engineering: Implications and Ethics Symposium, University of Wisconsin, Stevens Point, 2 April 1987
    6 27
    Institute for Theological Encounter with Science and Technology, Washington, D.C., 10-12 April 1987
    6 28
    Hilldale Lectures, University of Wisconsin, 15 April 1987
    6 29
    NIH Day, NIH, 4 May 1987
    6 30-31
    Fourth International Congress on Inborn Errors of Metabolism, Sendai, Japan, 27-30 May 1987
    6 32
    International Symposium on Fetal Therapy, Dearborn, MN, 6 June 1987
    6 33
    Conference on Gene-Splicing, Eastern College, St. Davids, PA, 27-30 June 1987
    6 34
    Workshop on the Molecular Biology of Mental Restoration, NIH, 1-2 September 1987
    6 35
    Society of Pediatric Pathology, Washington, D.C., 18 September 1987
    6 36
    Current Iron Chelator Study Compound, NIH, 22 September 1987
    6 37
    Hepatitis B Viruses, Cold Spring Harbor, NY, 28 September-1 October 1987
    6 38
    Mid-American Molecular Biology Colloquium, Afton, OK, 4-7 October 1987
    6 39
    National Heart, Lung and Blood Advisory Council Meeting, NIH, 22 October 1987
    6 40
    Senate Staff Meeting, Dirksen Senate Office Building, Washington, D.C., 23 October 1987
    6 41
    Scientific Advisory Council, Children's Hospital Medical Center, Cincinnati, 30 November 1987
    6 42
    Immunology Council's Annual Symposium, Johns Hopkins University, 2 November 1987
    6 43
    Molecular Biology of Hemopoiesis, Rye Brook, NY, 6-7 November 1987
    6 44
    American Association of Pathologists, Washington, D.C., 8 November 1987
    6 45
    American Society of Hematology, Washingnton, D.C., 5-8 December 1987
    6 46
    Foundation for Advanced Education in the Science, Inc., Bethesda, 7 January 1988
    6 47
    National Conference of Catholic Bishops, Washington, D.C., 22-24 January 1988
    6 48
    Dr. Parry - Medical Genetics Elective, NIH, 29 January 1988
    6 49
    Gene Therapy in Animals, UCLA, 6-12 February 1988
    6 50
    Medical College of Wisconsin, 13 February 1988
    6 51
    American College of Physicians, New York, NY, 3-5 March 1988
    6 52
    Peripatetic Club Meeting, NIH, 25-26 March 1988
    6 53
    Annual Biology Gatlinburg Conference, Oak Ridge National Laboratory, TN, 11-14 April 1988
    6 54
    Programs of Excellence in Molecular Biology, NIH, 1-3 June 1988; 19-20 April 1989
    6 55
    Association of American Physicians, Washington, D.C., 29 April-2 May 1988
    6 56
    Immune Deficiency Foundation Symposium, Washington, D.C., 5 May 1988
    6 57
    RNA Tumor Viruses, Cold Spring Harbor, NY, 17-22 May 1988
    6 58
    Gene Therapy: A Progress Report - Clinical Center Grand Rounds, 25 May 1988
    6 59
    Food and Drug Administration, Center for Drug Evaluation and Research Seminar, Bethesda, 1 June 1988
    6 60
    Biotechnology Seminar Series - Prospects for Human Gene Therapy, 7 June 1988
    6 61
    Bionet Training Seminar, Mountain View, CA, 15-17 July 1988
    6 62
    Protocol Meeting on Iron Chelator Study, NIH, 17 August 1987
    6 63
    Laboratory of Tumor Cell Biology Annual Meeting, Bethesda, 22-26 August 1988
    6 64
    Intelligenetics/Bionet Users Group Meeting III, NIH, 25 August 1988
    6 65
    Sixth Conference on Hemoglobin Switching, Airlie House, VA, 25-28 September 1988
    6 66
    NHLBI Intramural Research Day, 21 October 1988
    6 67
    American Association of Pathologists, Bethesda, 2 November 1988
    6 68
    Minority Access to Research Careers Scholars Conference, 2-5 November 1988
    6 69
    Children's Hospital Medical Center, Cincinnati, OH, 10-12 November 1988
    7 1
    Molecular Mechanisms and Strategies, NIH, 30 November-1 December, 1988
    7 2
    NIH Science Writers Guild - "Who Decides When Scientific Findings Become Public Information: Scientists or Reporters?", NIH, 6 December 1988
    7 3
    AIDS-Branch Seminar, Bethesda, 13 December, 1988
    7 4
    Genetic Therapy, Inc., Workshop, Rockville, MD, 18 January 1989
    7 5
    Washington Journalism Center's Conference for Journalists on Health Issues, Washington, D.C., 25 January 1989
    7 6
    S/L Meeting, Nutley, NJ, 9 February 1989
    7 7
    Biomedical Ethics Advisory Committee, Washington, D.C., 17-18 February 1989
    7 8
    Symposium on Scientific Journals, Chicago, 9 May 1989
    7 9
    International ABC Biotechnology Meeting, Washington, D.C., 30 March 1989
    7 10
    RNA Tumor Viruses, Cold Spring Harbor, NY, 24-28 May 1989
    7 11
    Hastings Center 20th Anniversary Meeting, Briarcliff Manor, NY, 9-10 June 1989
    7 12
    American Association for the Advancement of Science Committee on Scientific Freedom and Responsibility, Washington, D.C., 21 June 1989
    7 13
    Annual Meeting of the Laboratory of Tumor Cell Biology, Washington, D.C., 20-26 August 1989
    7 14
    American Academy of Medicine of the District of Columbia, Cosmos Club, Washington, D.C., 4 October 1989
    7 15
    Walter Reed Retrovirus Research Group, Rockville, 13 October 1989
    7 16
    15th Annual Frederick Stohlman, Jr. Memorial Symposium, Boston, 18 October 1989
    7 17
    American Association of Pathologists, Bethesda, 22 October 1989
    7 18
    Genes, Genomes and Genetics, Coriell Institute for Medical Research, Cherry Hill, NJ, 26 October 1989
    7 19
    International Federation of Catholic Universities Research Committee of International Study, Group on Bioethics, Georgetown University, 27-28 October 1989
    7 20
    Conference on Gene Manipulation and Human Disease, Boston, 9-10 November 1989
    7 21
    NHLBI AIDS Ad Hoc Working Group, NIH, 20 November 1989
    7 22
    Thrombolysis, NIH, 29-30 November 1989
    7 23
    St. Jude's Hospital, Memphis, TN , 7 December 1989
    7 24
    NIH Consensus Development Conference - consensus statement, 21-23 May 1990
     
    Series 4: Writings, 1984-1990 [series]:
     
    By Others [subseries]:
    8 1
    "Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase" (1988), c.1988
    8 2
    "Pegademase", 1990
    8 3
    "Expression of human adenosine deaminase in mice transplanted with hemopoietic stem cells infected with amphotropic retroviruses", 1990
    8 4
    Federal Register - DHS articles (1990), c.1990
     
    By Anderson [subseries]:
    8 5
    Preparation of adenosine deaminase (ADA) - corrected T cells for human gene therapy - abstract - Anderson a co-author, c.1984
    8 6
    "Prospects for human gene therapy" - Anderson, 1984
    8 7
    Gene expression in mice after high efficiency retroviral-mediated gene transfer" - Anderson a co-author, 1985
    8 8
    "Expression of human adenosine deaminase in nonhuman primates after retrovirus mediated gene transfer" - Anderson a co-author, 1987
    8 9
    Understanding gene transfer therapy - Pamphlet - drafts, 1988-1989
    8 10
    "In vivo expression and survival of gene-modified rhesus T-lymphocytes" - draft, Anderson co-author, 1990
     
    Series 5: Audiovisual Materials, 1985-1995 [series]:
     
    Gene Therapy [subseries]:
    9
    "Genetic Gamble" - NOVA, WGBH [vhs videocassette], 1985
    9
    N2/TIL skit [vhs videocassette], October 1988
    9
    Patient Interview - Maurice Kuntz [vhs videocassette] 13:55, c.1989
    9
    "Gene Therapy" (Cindy Cutshall/Culver) - tapes 1, 2, 3 [vhs videocassette] 44:20, 1990
    9
    "The Cline Affair" - BBC Antenna Horizon [vhs videocassette], 6 July 1989
    9
    NIH/NHLBI - B-Roll Dr. W. French Anderson [vhs videocassette] 7:57, 27 July 1990
    9
    "Gene Therapy" (DeSilva informed consent) [vhs videocassette} 100:00, 14 September 1990
    9
    BioEast /91 - 9114 Human Gene Therapy: Clinical IND and Practical Considerations [vhs videocassette], 1991
    9
    "Women's Health Special" - Physician's Journal Update [vhs videocassette] 7:00, 1991
    9
    Gene Therapy Patient Recognition Program: 1st Gene Therapy anniversary Party, tapes 1-4 [vhs videocassette] 56:30, 14 September 1991
    9
    One Hundredth Commencement Program, University of Oklahoma - honorary degree recipients [vhs videocassette], 9 May 1992
    9
    The Secret of Life - Tae Kwon Do sequence [vhs videocassette] 60:00, 27 July 1992
    9
    "Gene Therapy" - Beyond 2000, series 9, show 29 [vhs videocassette], 1993
    9
    "Genetic Screening" - Beyond 2000, series 9, show 30 [vhs videocassette], 1993
    9
    "Children by Design" - The Secret of Life, PBS, David Suzuki [vhs videocassette], 1993
    9
    The Secret of Life - diseases - race car out footage [vhs videocassette], 9 July 1993
    9
    BioEast - G09 Challenges in Human Gene Therapy - PBS special [vhs videocassette], 1994
    9
    Vision: celebrating 25 years of research [vhs videocassette] 13:00, 1994
    9
    48 Hours, Marked For Life - Dan Rather [vhs videocassette], 30 March 1994
    9
    Oklahoma - Oklahoma Heritage Association [vhs videocassette], 1995
    9
    "In Our Lifetime" - USC final master [vhs videocassette], 1995
    9
    Dr. French Anderson, Alpern Ad Hoc - USC raw footage [vhs videocassette], 1995
     
    W. French Anderson Lectures [subseries]:
    9
    "Prospects for Human Gene Therapy" - FDA Seminar [Umatic videocassette] 60:00, 18 February 1986
    9
    "Human Gene Therapy" - 1991 Cartwright Lecture [2 vhs videocassettes] 72:00, 1991
    9
    "Genetic Engineering and Humanness" - Washington Cathedral [vhs videocassette] 67:00, 30 September 1991
    9
    "Gene Therapy" - PHS Technology Transfer Forum, Lister Hill Auditorium [vhs videocassette] 45:00, 14 November 1991
    9
    "Human Gene Therapy" - G. Burroughs Mider Lecture [vhs videocassette] 87:41, 1992
    9
    Molecular Miracles: Human Gene Therapy and the Future of Modern Medicine [vhs videocassette] 47:00, 1993
    9
    "Gene Therapy in the Treatment of Cancer" - Advancements in Cancer Therapy: an oncology video update, volume 3 [vhs videocassette] 30:00, 7 October 1993
    9
    AAMC Plenary Session [2 vhs videocassettes], 31 October 1994
     
    Clips From News Programs [subseries]:
    9
    Newsclips 1989-1990 - USC School of Medicine [videocassette], 1989-1990
    9
    "Gene Therapy" - CBS News, 6/25/1989; CBS News, 1/1/1990 [vhs videocassette], 25 June 1989; 1 January 1990
    9
    "Human Gene Transfer" - NBC National News [vhs videocassette], 22 May 1989
    9
    1) "Genetic Transfer at NIH" - WRC-TV NBC Nightly News, 5/22/89; 2) WUSA-TV Eyewitness News, 5/23/89; 3) CNN Newswatch, 5/22/89 [vhs videocassette] 6:10, 22-23 May 1989
    9
    1) "Bubble Boy-Cancer Therapy" - CNN TV, 7/30/90; 2) "Human Genome Therapy" CBS TV and ABC TV, 7/31/90 [vhs videocassette], 30-31 July 1990
    9
    Dr. Melvin Burger on Immune Disorders - Local News (Cleveland) [vhs videocassette], 2 August 1990
    9
    1) "Gene Therapy" - CBS Evening News, 9/13/90; 2) WUSA, 9/13/90; 3) Today, 9/14/90; 4) CBS This Morning, 9/14/90 [vhs videocassette], 13-14 September 1990
    9
    1) CNN Morning News; 2) CNN News from Medicine; 3) Ch 9 Eyewitness News; 4) Ch 4 NBC Nightly News; 5) CBS Evening News; 6) McNeil-Lehrer News; 7) Ch 7 ABC News [vhs videocassette], 14 September 1990
    9
    "Gene Therapy" - McNeil-Lehrer News Hour [vhs videocassette] 11:30, 14 November 1990