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Ward Darley Papers 1905-1968
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Series V: Laboratory Work and Research Publications, 1965-1997 [series]:

As a lifelong scientist Rodbell was a prolific researcher and writer. This series, divided into five subseries, consists of Rodbell's laboratory work and extensive research publications. The first subseries, arranged chronologically, contains the contents of eight laboratory notebooks from 1965 to 1976, a 1966 experiment on adenyl assay, and a file of 1971 experiment results. These important files record a number of G-protein experiments done by various scientists in Rodbell's laboratory. These experiments document the discovery of signal transduction. Mostly consisting of graphs and scientific findings these notebooks feature some charts drawn by Rodbell, and other scientific findings that led to the discovery of GTP (guanosine triphosphate) and the role of G-proteins in cellular communication. The loose papers were removed from their original binders and three of the original binders make up the second subseries. The binders feature unique illustrations and commentary by Rodbell's colleagues. The third subseries consists of three files of miscellaneous figures and charts mostly relating to GTP that appeared in various Rodbell publications.

 
V.1 Laboratory Notebooks [subseries]:
16 1
"Anne Butler Jones", September-November 1965 [part 1]
16 2
"Anne Butler Jones", September-November 1965 [part 2]
16 3
"Anne Butler Jones", September-November 1965 [part 3]
16 4
[Martin Rodbell], "Solutions for Adenyl Cyclase Assay", April 1966
16 5
[Hendrik Michiel Jan] "Krans II", 1969-1970 [part 1]
16 6
[Hendrik Michiel Jan] "Krans II", 1969-1970 [part 2]
16 7
[Hendrik Michiel Jan] "Krans II", 1969-1970 [part 3]
16 8
[Hendrik Michiel Jan] "Krans II", 1969-1970 [part 4]
16 9
[Hendrik Michiel Jan] "Krans II", 1969-1970 [part 5]
16 10
Hendrik Michiel Jan Krans, Experiment Results, 1971
16 11
"1973 Summary, James P. Harwood", January-August 1973 [part 1]
16 12
"1973 Summary, James P. Harwood", January-August 1973 [part 2]
16 13
"1973 Summary, James P. Harwood", January-August 1973 [part 3]
16 14
"GTP" [guanosine triphosphate], 1975-1976 [part 1]
16 15
"GTP" [guanosine triphosphate], 1975-1976 [part 2]
16 16
"GTP" [guanosine triphosphate], 1975-1976 [part 3]
17 1
Untitled binder of experiments, 1975-1976 [part 1]
17 2
Untitled binder of experiments, 1975-1976 [part 2]
17 3
Untitled binder of experiments, 1975-1976 [part 3]
17 4
Untitled binder of experiments, 1975-1976 [part 4]
17 5
"Ann [Welton] and Andrew [Newby] I, Joint Experiments", 1975-1976 [part 1]
17 6
"Ann [Welton] and Andrew [Newby] I, Joint Experiments", 1975-1976 [part 2]
17 7
"Ann [Welton] and Andrew [Newby] I, Joint Experiments", 1975-1976 [part 3]
17 8
"Ann [Welton] and Andrew [Newby] I, Joint Experiments", 1975-1976 [part 4]
17 9
"Ann [Welton] and Andrew [Newby] II, GTPase Assay", March-November 1976 [part 1]
17 10
"Ann [Welton] and Andrew [Newby] II, GTPase Assay", March-November 1976 [part 2]
17 11
"Ann [Welton] and Andrew [Newby] II, GTPase Assay", March-November 1976 [part 3]
17 12
"Binding, 'What a Bind?'", April-July 1976 [part 1]
17 13
"Binding, 'What a Bind?'", April-July 1976 [part 2]
17 14
"Binding, 'What a Bind?'", April-July 1976 [part 3]
17 15
"Binding, 'What a Bind?'", April-July 1976 [part 4]
17 16
"Binding, 'What a Bind?'", April-July 1976 [part 5]
 
V.2 Binders [subseries]:
18
"Ann [Welton] and Andrew [Newby] I, Joint Experiments", 1975-1976
18
"Ann [Welton] and Andrew [Newby] II, GTPase Assay", March-November 1976
18
"Binding, 'What a Bind?'", April-July 1976
 
V.3 Charts and Figures [subseries]:
18 1
Charts and Figures [part 1]
18 2
Charts and Figures [part 2]
18 3
Charts and Figures [part 3]
 
V.4 Reprints [subseries]:
19 1
"The actions of glucagon on the adenylae cyclase system" (1981) TO "The actions of hormones on adenylate cyclase systems" (1978)
19 2
"The actions of insulin and catabolic hormones on the plasma membrane of the fat cells" (1968) TO "Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins" (1979)
19 3
"Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes (1977)" TO "Evidence for specific binding sites for guanine nucleotides in adipocyte and hepatocyte plasma membranes. A difference in fate of GTP and guanosine 5'-(beta, gamma-imino) triphosphate" (1975)
19 4
"ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase" (1979) TO "Are Transducers the Response-Determining Step in Hormone Actions?" (no date)
19 5
"Beginnings of an Endocrinologist" (1991) TO "Bioinformatics: an emerging means of assessing environmental health" (1994)
19 6
"Carbachol-activated muscarinic (M1 and M3) receptors transfected into Chinese hamster ovary cells inhibit trafficking of endosomes" (1991) TO "The complex structure and regulation of adenylate cyclase" (1983)
19 7
"Current Contents Citation Classic" (1980) TO "The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated" (1993)
19 8
"Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes (1977)" TO "Evidence for specific binding sites for guanine nucleotides in adipocyte and hepatocyte plasma membranes. A difference in fate of GTP and guanosine 5'-(beta, gamma-imino) triphosphate" (1975)
19 9
"The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP" (1979) TO "5'-Guanylylimidodiphosphate, a potent activator of adenylate cyclase systems in eukaryotic cells" (1974)
19 10
"Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase" (1979) TO "The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon" (1971)
19 11
"The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action" (1971) TO "G-proteins have characteristics of cytoskeletal proteins: A basis for the programmable messenger theory" (1988)
19 12
"G-proteins have properties of multimeric proteins: An explanation for the role of GTPases in their dynamic behavior" (1993) TO "GTP stimulates and inhibits adenylate cyclase in fat cell membranes through distinct regulatory processes" (1977)
19 13
"The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activation" (1975) TO "A highly sensitive adenylate cyclase assay" (1974)
19 14
"Hormones, receptors, and adenyl cyclase activity in mammalian cells" (1969) TO "Hydroxybenzylpindolol and hydroxybenzylpropranolol: partial beta adrenergic agonists of adenylate cyclase in the rat adipocyte" (1976)
19 15
"Inactivation of glucagon by plasma membranes of rat liver" (1972) TO "Isoproterenol stimulates shift" (1990)
19 16
"Lecithin synthesis in liver" (1955) TO "Localization of lipoprotein lipase in fat cells of rat adipose tissue" (1964)
19 17
"Metabolism of chylomicron proteins in the dog" (1959) TO "The metabolism of isolated fat cells. IV. Regulation of release of protein by Lipolytic hormones and insulin" (1966)
19 18
"The metabolism of isolated fat cells. VII. Sodium-linked, energy-dependent, and ouabain-sensitive potassium accumulation in ghosts" (1969) TO "Multiple inhibitory and activating effects of nucleotides and magnesium on adrenal adenylate cyclase" (1975)
19 19
"The nature of proteins associated with dog and human chylomicrons (1959)" TO "N-terminal amino acid and lipid composition of lipoprotiens from chyle and plasma" (1958)
19 20
"Octyl glucoside extracts GTP-binding regulatory proteins from rat brain 'synaptoneurosomes' as large, polydisperse structures devoid of beta gammacomplexes and sensitive to disaggregation by guanine nucleotides (1990)" TO "Opiate receptor-mediated inhibition of adenylate cyclase in rat striatal plasma membranes" (1982)
19 21
"A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes (1975)" TO "Programmable messengers: a new theory of hormone action" (1985)
19 22
"Properties of the adenyl cyclase systems in liver and adipose cells: the mode of action of hormones (1970)" TO "Proteolysis activates adenylate cyclase in rat liver and AC-lymphoma cell independently of the guanine nucleotide regulatory site" (1980)
20 1
"The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule" (1971) TO "The removal and metabolism of triglycerides by perfused liver" (1964)
20 2
"Reversible activation of hepatic adenylate cyclase by guanyl-5'-yl-(alpha,beta-methylene)diphosphonate and guanyl-5'-yl imidodiphosphate" (1977) TO "Role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi-site transition states" (1975)
20 3
"The role of GTP-binding proteins in hormone action: adenylate cyclase and other transduction processes (no date)" TO "The role of GTP-binding proteins in signal transduction: from the sublimely simple to the conceptually complex" (1992)
20 4
"The role of GTP in coupling of hormone receptors and adenylate cyclase" (1979) TO "The role of nucleotide regulatory components in the coupling of hormone receptors and adenylate cyclase" (1978)
20 5
"Selective effects of organic mercurials on the GTP-regulatory proteins of adenylate cyclase systems" (1980) TO "Signal transduction: A twenty year history of G-proteins" (no date)
20 6
"Simple model for hormone-activated adenylate cyclase systems" (1976) TO "The structure of adenylate cyclase systems" (1981)
20 7
"Structure-function relationships in adenylate cyclase systems" (1982) TO "The structure of hormone-sensitive adenylate cyclase systems" (no date)
20 8
"Structure of the turkey erythrocyte adenylate cyclase system" (1981) TO "Toward a unifying hypothesis for the effects of cholera toxin catalysed adp-ribosylation in diverse adenylate cyclase systems" (1980)
20 9
Miscellaneous Writings and Reprints
 
V.5 Writings of Others [subseries]:
20 10
Vivian Joyce Goldberg, "Glucagon Action on Isolated Liver Cells" Ph.D. diss., Georgetown University, 1973
20 11
Citation list of reprints kept by Rodbell