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Title: Sol Spiegelman Papers
Creator: Spiegelman, Sol, 1914-
Dates: 1929-1983
Extent: 114.21 linear feet (96 boxes)
Abstract:Sol Spiegelman (1914-1983) was an American microbiologist who made several important contributions in the fields of microbial genetics and cancer research, particularly the discovery of RNA/DNA hybridization and the first synthesis of an infectious nucleic acid. Biographical material, correspondence, laboratory notebooks, published and unpublished writings, academic course material, subject files, memoranda, and illustrations document Sol Spiegelman's professional career as a microbiologist.
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Summary Information
• ...can microbiologist who made several important contributions in the fields of microbial genetics and cancer research, particularly the discovery of RNA/DNA hybridization and the first synthesis of an i ...
Biography
• ...archer, Sol Spiegelman made several important contributions in the fields of microbial genetics and cancer research. Spiegelman took an interest in biology at an early age. In 1933 he attended ...
• ...menon is known as switching a gene on or off, and has had serious implications in the fight against cancer. Spiegelman's data raised the possibility that the wild multiplication of cells which charac ...
• ... Spiegelman's data raised the possibility that the wild multiplication of cells which characterized cancer might be attributed to an (uncontrollable or unruly) mechanism rather than a genetic mutation ...
• ... he served as a Professor of Human Genetics and Development and as the Director of the Institute of Cancer Research. This move reflected Spiegelman's decision to focus his investigations fully on the ...
• ...rch. This move reflected Spiegelman's decision to focus his investigations fully on the problem of cancer. During the course of his RNA experiments he developed a technique that made it possible to ...
• ...ue for the presence of a virus; this laid the groundwork for his attempts to isolate a link between cancer and viral infections. Spiegelman demonstrated that RNA in a virus known to cause mammary tum ...
• ...RNA in a virus known to cause mammary tumors in mice was similar to sequences found in human breast cancer, which fueled his efforts to develop a clinically useful test for breast cancer in humans. In ...
• ...und in human breast cancer, which fueled his efforts to develop a clinically useful test for breast cancer in humans. In 1974 his career research was awarded the top American prize, the Lasker Award f ...
• ...d Spiegelman by naming him University Professor in 1975, and made him Director of its Comprehensive Cancer Center in 1980. He was still actively involved in cancer research at Columbia when he died o ...
• ...nd made him Director of its Comprehensive Cancer Center in 1980. He was still actively involved in cancer research at Columbia when he died on January 20, 1983. Brief Chronology ...
• ... 1969 Director of the Institute of Cancer Research and Professor of Human Genetics and Development in the College of Physicians and Sur ...
• ... 1980 Director of the Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University. ...
Collection Scope and Content Note
• ...renowned experiments including RNA-DNA hybridization and explorations in the causes of human breast cancer. The majority of these articles appear in eight bound volumes entitled "Spiegelman's Collect ...
Subject Terms
• ... Corporate Names Columbia University. Institute of Cancer Research University of Illinois (Urbana-Champaign ca ...
Contents List
Series 1: Personal and Biographical, 1946-1983   series
Obituaries, 1983   subseries
• ... 1 8 Cancer Research, 1983: : ...
Publicity, 1946-1983   subseries
• ... 1 20 Cancer Centers -- Cancer Research, 1979: ...
• ... 1 20 Cancer Centers -- Cancer Research, 1979: : ...
Series 2: Correspondence, 1946-1983   series
• ... 10 13 "Cancer Research" E.M. Ritzi, D. S. Martin, R. S. Stolfi and S. Spiegelman, ...
Series 3: Laboratory Notes and Notebooks, 1937-1976   series
• ...e are three broad sub-series: Sugar and Enzyme Studies; Enzyme, DNA, and RNA Studies; DNA, RNA, and Cancer Studies. Researchers should be aware of the existence of overlaps in the types of studies doc ...
• ...ty of the reverse transcription of RNA to DNA, and research into possible connections between human cancer and viruses. Of particular interest is the group of notebooks written by frequent collaborato ...
DNA, RNA, and Cancer Studies, 1966-1976   subseries
• ...1968: : DNA, RNA, and Cancer Studies, 1966-1976: : ...
• ... 92 1 [Cancer Research -- DNA Products, Tumors of the Nervous System], ...
• ... 42 2 [Cancer Tumours], 1972: : ...
• ... 92 2 [Human Cancer Studies -- Hodgkings, Lymphoma, and Lymphosacroma], 1 ...
• ...45 5 [Breast Cancer Experiments and Report], 1970-1973: ...
• ... 47 3 Elaine M. Gordon -- Cancer Research, 1971-1974: : ...
• ... 48 15 [Cancer Research], 1975: : ...
• ... 93 5 Dr. Wiernick Notes -- [Cancer Patients], 1974-1975: : ...
Series 4: Writings, 1936-1983   series
• ...NA hybridization and the biological mechanics of cancerous cells, in particular leukemia and breast cancer. Materials of significance are Spiegelman's collected bound reprints, which are grouped by da ...
Books, 1958-1982   subseries
Recent Results in Cancer Research series   subseries
• ... 1976: : Recent Results in Cancer Research series: 50 ...
• ...50 5 Platinum Coordination Complexes in Cancer Chemotherapy, By T.A. Connors and J.J. Roberts, 1974, ...
• ... 50 7 Complications of Cancer Chemotherapy, By G. Mathe and R.K. Oldham, 1974, [197 ...
• ... 8 Investigation and Stimulation of Immunity in Cancer Patients, By Mathe and R. Weiner, 1974, [1974-1980] ...
• ... 50 11 Cancer Registry, By E. Grundmann and E. Pedersen, 1975, [197 ...
• ...50 13 Breast Cancer, By G. St-Arneault, P. Band and L. Israel, 1976, [197 ...
• ... 50 14 Cancer Chemotherapy, By A. Clarysse, Y. Kenis, G. Mathe, 1976, ...
• ... 51 1 Cancer Active Immunotherapy, By G. Mathe, 1976, [1974-1980] ...
• ... 51 2 Lymphocytes, Macrophages, and Cancer, By G. Mathe etc., 1976, [1974-1980]: ...
• ... 51 3 Tactics and Strategy in Cancer Treatment, By Georges Mathe, 1977, [1974-1980] ...
• ... 51 4 Selective Heat Sensitivity of Cancer Cells, By A. Rossi-Fanelli etc., 1977, [1974-1980] ...
• ... 51 15 Thyroid Cancer, By W. Duncan, 1980, [1974-1980]: ...
• ... 51 16 Endocrine Treatment of Breast Cancer, By B. Henningsen, etc., 1980, [1974-1980]: ...
• ... 51 17 Cancer Chemo -- and Immuno -- Pharmacology, By G. Mathe and F.M. Muggia, 1980, ...
• ... 51 18 Cell Proliferation, Cancer, and Cancer Therapy: A Conference in Honor of Anna Goldfeder -- A Tribute to Anna Goldfeder, ...
• ... 51 18 Cell Proliferation, Cancer, and Cancer Therapy: A Conference in Honor of Anna Goldfeder -- A Tribute to Anna Goldfeder, ...
Articles, Sole Authorship, 1944-1982   subseries
• ... 18 Rehovot -- Opening Lecture -- Genes, Viruses and Human Cancer; a Molecular Approach, 1974 Mar : ...
• ... 19 Intra -- Science -- Molecular Evidence for Viral Agents in Human Cancer and its Chemotherapeutic..., 1974 Mar 4 : ...
• ... 20 Manuscript #299 Reprints 1000 -- The Etiology of Human Cancer Viewed as a Problem in Molecular Genetics; Lund, Sweden -- S. Spiegelman, ...
• ... 54 21 Human Cancer and the RNA Tumor Viruses -- Rochester, N.Y.; S. Spiegelman, ...
Articles, Collaborative Authorship, 1936-1976   subseries
• ... 59 4 Search for a Human Breast Cancer Virus -- Dan H. Moore, 1971: : ...
• ... 59 15 Human Cancer and the RNA Tumor Viruses, 1972: ...
• ...23 Molecular Probing for a Viral Etiology of Human Cancer -- Spiegelman et. al, 1972 Jul 7 : ...
• ... 59 27 8th FZBs Meeting -- Human Cancer and the RNA Tumor Viruses; Spiegelman, et. al, 1972 A ...
• ....H. -- Review of Contract 70-2049 -- Replication of Oncogenic RNA Viruses and its Relation to Human Cancer, 1972 Oct 28 : : ...
• ...Miles Symposium, Dr. Spiegelman, et. al., July, 1972 -- The Relevance of RNA Tumor Viruses to Human Cancer, 1972-1973: : ...
• ... 60 9 Pathobiology Annual '73 -- Breast Cancer: Molecular Probing; Schlom and S. Spiegelman, 1973 ...
• ... 20 Los Angeles -- Molecular Evidence for a Viral Etiology of Human Cancer; Spiegelman, Axel, Baxt, Gulati, Hehlmann, Kufe and J.S., ...
• ... 2 Biochemical Evidence for a Viral Involvement in Human Breast Cancer -- Schlom, Colcher, et al., 1974: ...
• ... 61 3 Breast Cancer = Molecular Probing for a Viral Etiology -- J. Schlom and S. Spiegelman, ...
• ... 61 11 The Presence in Human Breast Cancer of RNA Homologous to Mouse Mammary Tumor Virus -- Axel, Schlom, and Spiegelman, ...
• ... 13 Replication of Oncogenic RNA Viruses and its Relation to Human Cancer, 1974: : ...
• ... 61 21 Cancer -- S. Spiegelman -- Human Cancer and Animal Viral Oncology, ...
• ... 61 21 Cancer -- S. Spiegelman -- Human Cancer and Animal Viral Oncology, 1974 Feb 16: ...
• ... 61 22 The Molecular Genetics of Human Cancer and its Etiologic Implications -- S. Spiegelman, Axel, Baxt, Kufe, and Schlom, ...
• ... 61 28 Cancer Research -- Biochemical Charact. of Putative Subviral Particulates; Michalides, Spiegelman, S ...
• ... [NO1-CP-6-1010 -- Replication of Oncogenic RNA Viruses and its Relation to Human Cancer] S. Spiegelman, 1973-1975: : ...
Illustrations, 1958-1978   subseries
• ...65 39 Breast Cancer and MPMV, 1973: : ...
Series 5: Professional Activities, 1945-1982   series
Meetings, Symposia, Conferences, 1945-1981   subseries
• ... 66 20 Fourth International Cancer Research Congress, Sep. 2-7, 1947: ...
• ... 66 58 3rd Cancer Research Conference, Jun. 15-19, 1958: ...
• ... 70 15th Annual Symposium on Fundamental Cancer Research, Feb.23-25, 1961: : ...
• ... 67 12 American Association Cancer Research, Apr. 9, 1964, 1963-1964: ...
• ... 67 28 American Cancer Society Science Seminar Phoenix, Mar. 25-30, 1966 ...
• ... 54 Houston, Texas Symposium Fundamental Cancer Research Mar. 6-8, 1968: : ...
• ... 68 7 University of Michigan Cancer Retreat, Sep. 27-29, 1968, Ann Arbor, 1967-1968 ...
• ... 68 14 23rd Symposium on Fundamental Cancer Research -- Houston, Texas, Mar. 5-7, 1969: ...
• ... 68 46 Xth International Cancer Congress -- Houston, TX, May 22-29, 1970: ...
• ... 69 31 New York Cancer Society, Mar. 9, 1971: : ...
• ... 69 37 American Association for Cancer Research, Chicago, Illinois, Apr. 8-10, 1971 ...
• ... 70 5-6 National Cancer Plan -- Washington, D.C., Oct. 7-8 & Oct. 24-27, ...
• ... 70 13 Cancer Research Centers -- Bethesda, Maryland, Nov. 18-19, 1 ...
• ... 70 18 Memorial Hospital for Cancer & Allied Diseases, New York City, Dec. 14, 1971 ...
• ... 70 26 1972 Symposium on fundamental cancer Research, M.D. Anderson Hospital, Houston, Texas, Mar. 8-10, ...
• ... 70 29 National Cancer Advisory Board, Mar. 19-22, 1972: ...
• ... 70 30 USA - Australia Cancer Symposium -- Melbourne, Australia, Mar. 20-22, 1972 ...
• ... 70 46 Cancer Center Meetings -- Bethesda, Maryland, May 23, 1972 ...
• ... 70 49 7th Meetings on Breast Cancer in Animals & Man -- Grenoble, France, Jun. 12-14, ...
• ... 70 50 National Cancer Advisory Board, Jun. 19-21, 1972: ...
• ... 70 55 7th National Cancer Conference -- Los Angeles, CA, Sep. 27-29, 1972 ...
• ...70 56 Breast Cancer Virus Segment, Oct. 6, 1972: : ...
• ...70 57-58 National Cancer Advisory Board, Oct. 10-12, 1972: ...
• ... 1 Administrative Confidential -- National Cancer Institute, Oct. 12 [OVERSIZED], 1972: ...
• ... 70 62 American Cancer Society -- NYC, Oct. 21, 1972: : ...
• ... 70 64 Special Virus Cancer Program Meetings -- Hershey, PA, Oct. 29-Nov. 1, 1972 ...
• ... 71 4 National Cancer Advisory Board -- Nov. 20-22, 1972, 1972: ...
• ... 71 7 American Cancer Society Meetings, Dec. 5-8, 1972, Key Biscayne, Florida, ...
• ... 71 8 National Cancer Advisory Board -- Dec. 11-12, 1972, 1972-1973 ...
• ...71 9 Papanicolaou Cancer Research Institute -- Feb. 8, 1973, Miami, Fl., 1972- ...
• ...71 18-19 National Cancer Advisory Board -- Mar. 26-28, 1973, 1972-1973 ...
• ... 71 27 Children's Cancer Research Foundation - May 16, 1973, Boston, 1973 ...
• ... 71 34 National Cancer Advisory Board, Jun. 18-20, 1973: ...
• ... 71 46 National Cancer Advisory Board -- Sep. 30-Oct. 3, 1973: ...
• ... 71 47 The Institute for Cancer Research -- Oct. 11, 1973, Fox Chase, Pa., 1973 ...
• ... 71 55 National Cancer Advisory Board, Nov. 25-28, 1973: ...
• ... 71 56 American Cancer Society, Nov. 29, 1973: : ...
• ... 72 7-8 National Cancer Advisory Board Meeting, Mar. 18-20, 1974: ...
• ... 72 9 American Cancer Society, St. Augustine, Florida -- Mar. 25, 1974 ...
• ... 18 Jun. 10, 1974 & Jun. 17-18, 1974 -- NCI Frederick Cancer Research Center, 1974: : ...
• ... 72 19 Cancer Biology I Seminar, Aspen, Colorado -- Jul. 22-26, 197 ...
• ... 72 23 American Cancer Society, La Jolla, Cal. -- Sep. 24, 1974, 1974-1975 ...
• ... 72 28 XI International Cancer Congress, Florence, Italy -- Oct. 20-26, 1974 ...
• ... 72 31 Virus Cancer Program, Hershey, PA -- Nov. 10-13, 1974: ...
• ... 72 38 American Cancer Society -- Jan. 6 & 7 1975, NYC, 1974-1975 ...
• ... 72 39 Frederick Cancer Research Center -- Feb. 10-12, 1975, Frederick, MD., ...
• ... 72 47 American Association for Cancer Research, San Diego, Ca., May 8-10, 1975: ...
• ... 72 64 The Xth Meetings on Mammary Cancer in Experimental Animals and Man, Oct. 18, 1975 ...
• ... 73 20 Colloquia Cancer Res. Center, Jun. 17, 1976: : ...
• ...73 26 Israel Cancer Research Fund -- Oct. 12, 1976: : ...
• ... 73 37 National Cancer Advisory Board Meetings -- Jan. 24-26, 1977 ...
• ... 38 M.D. -- Ph. D. Seminar -- Molecular Evidence for Viral Agents in Human Cancer -- Feb. 8, 1977: : ...
• ...73 40 Israel Cancer Research Fund -- Mar. 24, 1977: : ...
• ...73 41 Breast Cancer Workshops -- Bethesda, MD, Mar. 28-29, 1977 ...
• ...73 61 Breast Cancer Family Workshop -- University of Utah, Nov. 8-9, 1977 ...
• ...73 63 Israel Cancer Research talk -- Temple Kehilath, Nov. 22, 1977 ...
• ... 73 69 Yale Comprehensive Cancer Center -- Lecture, Feb. 24, 1978: ...
• ...73 78 Israel Cancer Research Fund Fellowship Meetings, May 3, 1978 ...
• ... 74 5 11th Meetings on Mammalian Cancer in Experimental Animals and Man, Jun. 25-28, 1978 ...
• ... American Association for Clinical Chemistry -- AACC -- The Biochemistry of Cancer -- San Antonio, TX, Sep. 6-8, 1978: ...
• ...15 Future Trends in Clinical & Lab Research in Cancer -- Paris, France, Oct. 5-6, 1978: ...
• ... 74 24 Thymidine Cancer Workshop -- NCI -- Washington, D.C., Dec. 20, 1978 ...
• ...74 27 Large Bowel Cancer -- Houston, Jan. 31, 1979: : ...
• ... 74 31 Seminar Cancer Epidemiology, Feb. 27, 1979: : ...
• ... 35 N.Y. Science Advisory Board -- Israel Cancer Research Fund, Apr. 16, 1979: : ...
• ... 46 Cold Spring Harbor -- Virus, Naturally Occurring Cancer, Sep. 4-9, 1979: : ...
• ... 74 47 ACS Breast Cancer -- Waldorf Astoria, NY, Sep. 6-8, 1979: ...
• ... 74 63 Joint Conference Cancer -- Columbia U., Mar. 28-29, 1980: ...
• ... 75 1-2 12th Meetings on Mammary Cancer in Experimental Animals and Man, May 11-14, 1980 ...
• ... 4 Meetings -- National Surgical Adjuvant Project -- Breast & Bowel Cancer -- Banff, Canada, May 15-16, 1980: ...
• ... 75 22 Site Visit Clinical Cancer Education -- Dr. Ellison, Jan. 22, 1981: ...
• ... 75 29 Imperial Cancer Research Fund Laboratories, Mar. 2-3, 1981: ...
• ... 75 49 Virus and Human Cancer Meeting -- Washington, D.C., Jul. 14, 1981: ...
Committees, 1946-1982   subseries
• ... 76 7 Memorial Sloan-Kettering Cancer Center, 1973-1975: : ...
Series 7: Subject Files, 1929-1983   series
• ... 83 9 Clinical Cancer, undated: : ...
• ...84 4 Mammary Cancer, undated: : ...
• ... 84 20-22 Reading Guide to Cancer-Virology Literature, 1964-1968: : ...
• ... 23 Relationship of Virus Diseases and their Relevance to Cancer -- Ricardo Mesa-Tejada, undated: ...