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National Library of Medicine

Finding Aid to the Frank Lappin Horsfall Papers, 1940-1971

Archives and Modern Manuscripts Program, History of Medicine Division
Processed by HMD Staff
Date completed:
Encoded by Dan Jenkins


Summary Information
Title: Frank Lappin Horsfall Papers
Creator: Horsfall, Frank Lappin, 1906-1971
Dates: 1940-1971
Extent: 21 MS Boxes
Abstract:
Dr. Frank Horsfall was a microbiologist with the Rockefeller Hospital from 1934 to 1960, after which he became Director of the Sloan-Kettering Institute for Cancer Research until his death in 1971. Collection contains correspondence, diaries, memoranda, drafts of articles, laboratory studies and notes, reprints, printed matter, and photos.

Call number: MS C 191
Language: Collection materials primarily in English
Location: Materials stored offsite. Retrievals made last Friday of the month. Contact reesj@nlm.nih.gov for scheduling.

Access Restrictions:

Collection is not restricted. Contact the Reference Staff for information regarding access.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish. See the Reference Staff for details regarding rights.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Horsfall, Frank Lappin. Frank Lappin Horsfall Papers. 1940-1971. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD.; MS C 191.

Provenance:

Gift, 1975.


horsfallFinding Aid to the Frank Lappin Horsfall Papers, 1940-1971Archives and Modern Manuscripts Program, History of Medicine Division Version 1.0 History of Medicine Division, National Library of Medicine.
8600 Rockville Pike
Bethesda, Maryland, 20894
USA
Phone: (301) 402-8878 (Reference Desk)
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Email: hmdref@nlm.nih.gov
Machine-readable finding aid encoded by Dan JenkinsFinding aid is written in EnglishJuly 2004PUBLIC "-//National Library of Medicine::History of Medicine Division//TEXT (US::DNLM::MS C 191::Frank Lappin Horsfall Papers)//EN" "horsfall" converted from EAD 1.0 to 2002 by v1to02.xsl (sy2003-10-15).

National Library of Medicine

Finding Aid to the Frank Lappin Horsfall Papers, 1940-1971

Archives and Modern Manuscripts Program, History of Medicine Division
Processed by HMD Staff
Date completed:
Encoded by Dan Jenkins

Descriptive Summary

Horsfall, Frank Lappin, 1906-1971Frank Lappin Horsfall Papers Dates: 1940-197121 MS BoxesMS C 191 Materials stored offsite. Retrievals made last Friday of the month. Contact reesj@nlm.nih.gov for scheduling. Abstract:Dr. Frank Horsfall was a microbiologist with the Rockefeller Hospital from 1934 to 1960, after which he became Director of the Sloan-Kettering Institute for Cancer Research until his death in 1971. Collection contains correspondence, diaries, memoranda, drafts of articles, laboratory studies and notes, reprints, printed matter, and photos.Collection materials primarily in EnglishProvenance:

Gift, 1975.

Access Restrictions:

Collection is not restricted. Contact the Reference Staff for information regarding access.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish. See the Reference Staff for details regarding rights.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Horsfall, Frank Lappin. Frank Lappin Horsfall Papers. 1940-1971. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD.; MS C 191.

Biographical Note

Dr. Frank Lappin Horsfall (1906-1971) was born in Seattle, WA. He received his B.A. from the University of Washington in 1927 and attended medical school at McGill University, graduating in 1932. Trained as a surgeon, he spent his first year after medical school at the Peter Bent Brigham Hospital in Boston as a pathologist. He developed a severe hypersensitivity to formaldehyde, forcing him to leave his pathology studies, and ultimately, surgery. He spent another resident year at Montreal's Royal Victoria Hospital and Montreal General Hospital, but realized he could not work in any environment where formaldehyde was present. Thus, in the fall of 1934, he joined the pneumonia service of the Rockefeller Institute for Medical Research, embarking on a career in microbiology and infectious diseases.

Between 1934-1937, Horsfall's work at the Rockefeller Hospital centered on immunological reactions between pneumococcal capsular polysaccharides and the antibodies to them produced by immunization of various animals. His studies resulted in the use of rabbit antisera over that of horse serum as standard pneumonia treatment. However, this advance was soon displaced by the discovery of sulfonamide drugs. In 1937, Horsfall began a four-year term with the International Health Division of the Rockefeller Foundation and marks the beginning of his devotion to the study of viruses and the diseases they cause. Here he began his work on the human influenza virus and the pneumonia virus of mice (PVM), the two most significant highlights of his laboratory research career. Horsfall returned to the Rockefeller Hospital in 1941, becoming Vice President for Clinical Studies and Physician in Chief until he left in 1960. During World War II, he served in the Naval reserves as part of the Naval Medical Research Unit at the Rockefeller Hospital, concentrating on respiratory tract diseases, specifically primary atypical pneumonia.

Horsfall's second career as Director of the Sloan-Kettering Cancer Research Center was an important one, that of a scientific statesman guiding the research of the largest private cancer research institution. His work centered around his synthesis of ideas about carcinogens, especially as they related to the role of viruses as oncogenic agents, the interaction of viruses and chemical agents, immune processes that possible modified malignant change, and the role of chemotherapy. His leadership at Sloan-Kettering came at a time of change for cancer research. The role of chemical carcinogens became the central area of study in the 1960s. Horsfall forcefully argued in a number of important publications that viral and chemical carcinogens may be interrelated, and perhaps were even interdependent. This concept of interdependency between viruses and chemicals marked an important shift in cancer etiology and resulted in rapid advances in cancer research.

Horsfall was elected to the National Academy of Sciences in 1958, and was a member of the American Philosophical Society (1956) and the American Academy of Arts and Sciences (1967). He authored over 200 publications and received several honorary degrees. His professional awards include the Eli Lily Award in Bacteriology and Immunology (1937), and the Fiftieth Anniversary Gold Medal Award of the Peter Bent Brigham Hospital (1959).


Includes material relating to various science conferences, meetings, and lectures. Correspondents include Morris Fishbein, Peyton Rous, Thomas M. Rivers, Albert B. Sabin, Basil O'Conner, Jonas Salk, Stanhope Bayne-Jones, Detlev Bronk, George Corner, Rufus Cole, Abraham Flexner, P. B. Medawar, Irving H. Page, Luther Terry, David Rockefeller, Winthrop Rockefeller, Selman A. Waksman, Paul Weiss, and George H. Whipple.

Index Terms

These terms are indexed in the National Library of Medicine's on-line catalog LocatorPlus. Researchers wishing to find related materials should search the catalog using these terms.

    MeSH Subjects

    • Carcinogens
    • Microbiology
    • Neoplasms
    • Oncogenic Viruses
    • Pneumococcal Infections
    • Pneumonia, Pneumococcal
    • Pneumococcal Vaccines
    • Polysaccharides, Bacterial
    • Pathology
    • Virology
    Corporate Names

    • Rockefeller Institute for Medical Research
    • Sloan-Kettering Institute for Cancer Research

    Series Descriptions

    Personal and BiographicalBoxFolderContents1Biographical Data1PhotographsCorrespondence and Subject Files1Albert Lasker Awards, 1958-19601Alumnus Summa Laude Dignatus Award (Univ. of Washington), 19621American Academy of Art and Sciences, 1967-19711American Association for Cancer Research, 1961-19711American Association for the Advancement of Science, 19711American Association of Immunologists, 1946-19711American College of Physicians, 19681American Medical Association, 1947-19711American Philosophical Society, 1965-19712American Public Health Association, 1942-19712American Society for Clinical Investigation, 1948-19712American Society for Microbiology, 1960-19712Anderson Memorial Lecture (Univ. of Virginia), 19612Association of American Medical Colleges, 19602Association of American Physicians, 1944-19712Babies Hospital Lecture, 19512British Empire Cancer Campaign for Research (London), 19692Bronk, Detlev W., 1956-19662Cancer Section, Oklahoma Medical Research Foundation, 19662Century Association, 1963-19712Cole, Rufus, 1957-19672Columbia University Graduate School of Journalism Conference, 19622Committee on Health for Peace, 19582Conference on Congenital Malformation, 19633Dag Hammerskjold Fellowship Committee, 19623Duke University Seminars, 19553Excerpta Medica Foundation, 1958-19703Expert Advisory Panel on Virus Disease, 1962-19713Federation of American Societies for Experimental Biology, 1965-19713Fifth International Poliomyelitis Conference (Copenhagen), 19603First Conference on Congenital Malformation (London), 19603First International American Conference on Congenital Defects, 19623Forssman, Olof, 1952-19593Griffis Faculty Club, (FLH, Jr., membership), 1963-19713Harvard University, 19483Harvey Society, 1956-19713Health Research Council, 1958-19703Hellenic Anticancer Society, 19653Honorary Degree (Univ. of Alberta), 19633IBM Research and Engineering Management Conference, 19683Institute for Cancer Research, 1960-19703International Cancer Congress (Moscow), 19623International Conference on Leukemia-Lymphoma (Univ. of Michigan), 19674International Congress for Microbiology (Montreal), 19624Institute of Microbiology Scientific Advisory Committee, 1955-19624International Medical Congress, 1960-19714International Polio Congress (Geneva), 19574Interurban Clinical Club, 1956-19714Ito, Yohei, 1961-19684Jackson Memorial Laboratory, 19584James Ewing Society, 1960-19714Journal of Immunology, 1959-19634Kober Lecture (Georgetown University), 19644Macy Conference, 19564Management Advisory Council, Oak Ridge National Laboratory, 1968-19724Mayo Foundation Lecture, 19604McGill University (Doctor of Science Degree) [talk], 1963; 19704Medical Library Center of New York, 1958-19714Medical World News, 1959-19614Montreal Medico-Chirurgical Society, 19604National Academy of Sciences, 19635National Academy of Sciences, 1963-19716New York Academy of Medicine, 1950-19716National Foundation, 1950-19716National Tuberculosis Association Meeting (Chicago), 19596New York Academy of Sciences, 1949-19606New York City, Commission on Health Services, 19596New York City, Department of Health, 1956-19656New York City, Science and Technology Advisory Council, 1965-19716New York Hospital - Cornell Medical Center, 19676New York Hospital lectures, 1951-19596New York University Hospital, 19576Niles Memorial Lecture (Cornell University), 19626New York Clinical Society Lecture, 19527"On the Unity of Science", 19617Oklahoma Medical Research Foundation, 1959-19697Osler Society Lecture, 19657Pan American Medical Association, 1965-19717Perspectives in Virology, 1953-19707Peter Bent Brigham Hospital, 50th Anniversary Gold Medal Award, 19637Public Health Research Institute (New York City), 1957-19707Practitioners Society of New York, 1954-19717President's Commission on Heart Disease, Cancer and Stroke, 19647Rivers, Thomas M., 1962-19637Rous, Peyton, 1960-19708Royal College of Physicians and Surgeons, (Canada) Honorary Fellowship, 19668Royal Society of Medicine, 1958-19718Sabin, Albert B., 1959-19658Science Advisory Council to the New York State Legislature, 1963-19658Seattle General Hospital Lectures, 19408Sigma XI, (Rockefellers Institute Chapter), 19588Sloan-Kettering Institute, 1966-19708Society of Actuaries, 19619Sweden-Lectures, 19469Syracuse-Lecture, 19429Textbook of Medicine, 19679Tiselius, Anne, 1947-19659Trimble Lecture - Maryland Medical and Chirurgical Faculty, 19439Trudeau Foundation, Advisory Committee, 19579Union Club, 1965-19719University Club, 1961-19719University of Washington Dedication, Health Sciences Building, 19609U.S. Department of Defense, 1957-19709U.S. - Japan Committee on Scientific Cooperation, 1962-19669Viral and Rickettsial Registry, 1958-19719Volkert, Mogens, 1946-19659Walter M. Brickner Memorial Lecture, 19609W.B. Saunders Company, 1961-19639Weizmann Institute of Science, 1952-19709World's Fair Committee, New York Academy of Medicine, 19619World Wide Abstracts, 1958-19669Yale Medical Society, 195110General Correspondence11Miscellaneous items, A - R12Miscellaneous items, R - ZResearch Studies and Reprints13Research Studies14Research Studies15Research Studies16Research Studies17Research Studies, Rivers-Horsfall book18Reprints19ReprintsDiaries, 1958-197020Diaries, 1958-196221Diaries, 1963-1970

    Collection Scope and Content Note

    Includes material relating to various science conferences, meetings, and lectures. Correspondents include Morris Fishbein, Peyton Rous, Thomas M. Rivers, Albert B. Sabin, Basil O'Conner, Jonas Salk, Stanhope Bayne-Jones, Detlev Bronk, George Corner, Rufus Cole, Abraham Flexner, P. B. Medawar, Irving H. Page, Luther Terry, David Rockefeller, Winthrop Rockefeller, Selman A. Waksman, Paul Weiss, and George H. Whipple.

    Contents List
    Box | Folder Title
     
    Personal and Biographical [series]:
    1
    Biographical Data
    1
    Photographs
     
    Correspondence and Subject Files [series]:
    1
    Albert Lasker Awards, 1958-1960
    1
    Alumnus Summa Laude Dignatus Award (Univ. of Washington), 1962
    1
    American Academy of Art and Sciences, 1967-1971
    1
    American Association for Cancer Research, 1961-1971
    1
    American Association for the Advancement of Science, 1971
    1
    American Association of Immunologists, 1946-1971
    1
    American College of Physicians, 1968
    1
    American Medical Association, 1947-1971
    1
    American Philosophical Society, 1965-1971
    2
    American Public Health Association, 1942-1971
    2
    American Society for Clinical Investigation, 1948-1971
    2
    American Society for Microbiology, 1960-1971
    2
    Anderson Memorial Lecture (Univ. of Virginia), 1961
    2
    Association of American Medical Colleges, 1960
    2
    Association of American Physicians, 1944-1971
    2
    Babies Hospital Lecture, 1951
    2
    British Empire Cancer Campaign for Research (London), 1969
    2
    Bronk, Detlev W., 1956-1966
    2
    Cancer Section, Oklahoma Medical Research Foundation, 1966
    2
    Century Association, 1963-1971
    2
    Cole, Rufus, 1957-1967
    2
    Columbia University Graduate School of Journalism Conference, 1962
    2
    Committee on Health for Peace, 1958
    2
    Conference on Congenital Malformation, 1963
    3
    Dag Hammerskjold Fellowship Committee, 1962
    3
    Duke University Seminars, 1955
    3
    Excerpta Medica Foundation, 1958-1970
    3
    Expert Advisory Panel on Virus Disease, 1962-1971
    3
    Federation of American Societies for Experimental Biology, 1965-1971
    3
    Fifth International Poliomyelitis Conference (Copenhagen), 1960
    3
    First Conference on Congenital Malformation (London), 1960
    3
    First International American Conference on Congenital Defects, 1962
    3
    Forssman, Olof, 1952-1959
    3
    Griffis Faculty Club, (FLH, Jr., membership), 1963-1971
    3
    Harvard University, 1948
    3
    Harvey Society, 1956-1971
    3
    Health Research Council, 1958-1970
    3
    Hellenic Anticancer Society, 1965
    3
    Honorary Degree (Univ. of Alberta), 1963
    3
    IBM Research and Engineering Management Conference, 1968
    3
    Institute for Cancer Research, 1960-1970
    3
    International Cancer Congress (Moscow), 1962
    3
    International Conference on Leukemia-Lymphoma (Univ. of Michigan), 1967
    4
    International Congress for Microbiology (Montreal), 1962
    4
    Institute of Microbiology Scientific Advisory Committee, 1955-1962
    4
    International Medical Congress, 1960-1971
    4
    International Polio Congress (Geneva), 1957
    4
    Interurban Clinical Club, 1956-1971
    4
    Ito, Yohei, 1961-1968
    4
    Jackson Memorial Laboratory, 1958
    4
    James Ewing Society, 1960-1971
    4
    Journal of Immunology, 1959-1963
    4
    Kober Lecture (Georgetown University), 1964
    4
    Macy Conference, 1956
    4
    Management Advisory Council, Oak Ridge National Laboratory, 1968-1972
    4
    Mayo Foundation Lecture, 1960
    4
    McGill University (Doctor of Science Degree) [talk], 1963; 1970
    4
    Medical Library Center of New York, 1958-1971
    4
    Medical World News, 1959-1961
    4
    Montreal Medico-Chirurgical Society, 1960
    4
    National Academy of Sciences, 1963
    5
    National Academy of Sciences, 1963-1971
    6
    New York Academy of Medicine, 1950-1971
    6
    National Foundation, 1950-1971
    6
    National Tuberculosis Association Meeting (Chicago), 1959
    6
    New York Academy of Sciences, 1949-1960
    6
    New York City, Commission on Health Services, 1959
    6
    New York City, Department of Health, 1956-1965
    6
    New York City, Science and Technology Advisory Council, 1965-1971
    6
    New York Hospital - Cornell Medical Center, 1967
    6
    New York Hospital lectures, 1951-1959
    6
    New York University Hospital, 1957
    6
    Niles Memorial Lecture (Cornell University), 1962
    6
    New York Clinical Society Lecture, 1952
    7
    "On the Unity of Science", 1961
    7
    Oklahoma Medical Research Foundation, 1959-1969
    7
    Osler Society Lecture, 1965
    7
    Pan American Medical Association, 1965-1971
    7
    Perspectives in Virology, 1953-1970
    7
    Peter Bent Brigham Hospital, 50th Anniversary Gold Medal Award, 1963
    7
    Public Health Research Institute (New York City), 1957-1970
    7
    Practitioners Society of New York, 1954-1971
    7
    President's Commission on Heart Disease, Cancer and Stroke, 1964
    7
    Rivers, Thomas M., 1962-1963
    7
    Rous, Peyton, 1960-1970
    8
    Royal College of Physicians and Surgeons, (Canada) Honorary Fellowship, 1966
    8
    Royal Society of Medicine, 1958-1971
    8
    Sabin, Albert B., 1959-1965
    8
    Science Advisory Council to the New York State Legislature, 1963-1965
    8
    Seattle General Hospital Lectures, 1940
    8
    Sigma XI, (Rockefellers Institute Chapter), 1958
    8
    Sloan-Kettering Institute, 1966-1970
    8
    Society of Actuaries, 1961
    9
    Sweden-Lectures, 1946
    9
    Syracuse-Lecture, 1942
    9
    Textbook of Medicine, 1967
    9
    Tiselius, Anne, 1947-1965
    9
    Trimble Lecture - Maryland Medical and Chirurgical Faculty, 1943
    9
    Trudeau Foundation, Advisory Committee, 1957
    9
    Union Club, 1965-1971
    9
    University Club, 1961-1971
    9
    University of Washington Dedication, Health Sciences Building, 1960
    9
    U.S. Department of Defense, 1957-1970
    9
    U.S. - Japan Committee on Scientific Cooperation, 1962-1966
    9
    Viral and Rickettsial Registry, 1958-1971
    9
    Volkert, Mogens, 1946-1965
    9
    Walter M. Brickner Memorial Lecture, 1960
    9
    W.B. Saunders Company, 1961-1963
    9
    Weizmann Institute of Science, 1952-1970
    9
    World's Fair Committee, New York Academy of Medicine, 1961
    9
    World Wide Abstracts, 1958-1966
    9
    Yale Medical Society, 1951
    10
    General Correspondence
    11
    Miscellaneous items, A - R
    12
    Miscellaneous items, R - Z
     
    Research Studies and Reprints [series]:
    13
    Research Studies
    14
    Research Studies
    15
    Research Studies
    16
    Research Studies
    17
    Research Studies, Rivers-Horsfall book
    18
    Reprints
    19
    Reprints
     
    Diaries, 1958-1970 [series]:
    20
    Diaries, 1958-1962
    21
    Diaries, 1963-1970