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National Library of Medicine

Finding Aid to the Stanley N. Cohen Papers, 1948-2016

History of Medicine Division
Processed by Jim Labosier
Processing Completed March 2018
Encoded by Jim Labosier


Summary Information
Title: Stanley N. Cohen Papers
Creator: Cohen, Stanley N.
Dates: 1948-2016
Extent: 120 linear feet (99 boxes + 36.6 GB electronic records)
Abstract:
Correspondence, email and electronic records, laboratory notebooks and workpapers, grant files, reports and journal articles, notes, lectures, awards, honors, and memorabilia document the academic and professional career of Stanford University geneticist Stanley N. Cohen. The collection comprehensively covers the many facets of Cohen's career from his early work in computational medical diagnosis, to the discovery of recombinant DNA technology, to contemporary research on degenerative neurological diseases.

Call number: MS C 623
Language: Collection materials primarily in English
Location: Materials stored onsite. History of Medicine Division. National Library of Medicine

Access Restrictions:

No restrictions on access.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Cohen, Stanley N. Stanley N. Cohen Papers. 1948-2016. Located in: Archives and Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 623.

Provenance:

Gift, Stanley Cohen, 2016 Aug. 23, Accession #2016-025, 2016-033a, 2017-022.


cohen623Finding Aid to the Stanley N. Cohen Papers, 1948-2016History of Medicine Division. Archives and Modern Manuscripts Collection1.0History of Medicine Division, National Library of Medicine.
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Machine-readable finding aid encoded by Jim LabosierFinding aid is written in English

National Library of Medicine

Finding Aid to the Stanley N. Cohen Papers, 1948-2016

History of Medicine Division
Processed by Jim Labosier
Processing Completed March 2018
Encoded by Jim Labosier

Descriptive Summary

Cohen, Stanley N.Stanley N. Cohen Papers Dates: 1948-2016120 linear feet (99 boxes + 36.6 GB electronic records)MS C 623Materials stored onsite. History of Medicine Division. National Library of MedicineCollection materials primarily in EnglishAbstract:Correspondence, email and electronic records, laboratory notebooks and workpapers, grant files, reports and journal articles, notes, lectures, awards, honors, and memorabilia document the academic and professional career of Stanford University geneticist Stanley N. Cohen. The collection comprehensively covers the many facets of Cohen's career from his early work in computational medical diagnosis, to the discovery of recombinant DNA technology, to contemporary research on degenerative neurological diseases.Provenance:

Gift, Stanley Cohen, 2016 Aug. 23, Accession #2016-025, 2016-033a, 2017-022.

Access Restrictions:

No restrictions on access.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Cohen, Stanley N. Stanley N. Cohen Papers. 1948-2016. Located in: Archives and Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 623.

Biographical Note

Born in Perth Amboy, New Jersey February 17, 1935, Stanley Norman Cohen is Kwoh-Ting Li professor of genetics at Stanford University School of Medicine. Cohen and UC San Francisco scientist Herbert Boyer were the first scientists to transplant genes from one living organism to another and is often considered the birth of genetic engineering and DNA therapies. In addition to the medical advances produced by their work, the financial impact of the patents for the Boyer-Cohen processes to both Stanford and UCSF marked a shift in the way universities recognized the commercial value of their scientists and helped launch the nascent biotechnology industry. Cohen's DNA cloning research was the result of his interest in basic scientific inquiry into fundamental natural phenomena, not to create new tools for diagnosing human disease. This ethos and commitment to basic scientific research is a defining principle of Cohen's work.

Cohen was raised and educated in the Garden State. His broad range of intellectual curiosity, though not confined to academia, led to distinctive scholarly achievements at Perth Amboy High School and Rutgers University. In additional to his scientific skills, young Cohen was a successful debater, banjo and ukulele musician, and published pop music composer. After graduating from Rutgers Cohen shifted his scientific ambitions from physics to medicine and continued his studies at the University of Pennsylvania School of Medicine, where he graduated with a medical degree in 1960.

For the next seven years, Dr. Cohen held internships and fellowships at Mt. Sinai Hospital in New York City, University Hospital in Ann Arbor, Michigan, and Duke University Hospital in Durham, North Carolina, among other institutions. While at the National Institute for Arthritis and Metabolic Diseases he refocused his efforts toward a combination of basic research with clinical practice. As a post-doctoral researcher at the Albert Einstein College of Medicine in 1967 he taught while also studying the mechanisms which control gene expression.

Upon accepting a position with Stanford University in 1968, Dr. Cohen began experimenting with plasmids to understand the mechanisms that underlie antibiotic resistance. Plasmids are genetic elements within bacteria. They independently reproduce within bacteria molecules, generating drug resistance genes. As such, plasmids are an obvious starting point for studying how and why bacteria develop resistance to antibiotics. To do this work it was necessary to develop a way to pull plasmids apart, glue segments of them back together again, then propagate and clone new combinations of plasmid genes in living cells.

In collaboration with Norman Davidson and Phillip Sharp at Caltech, Dr. Cohen's lab initiated a plasmid study using electron microscopy. These investigations proved a link between bacterial DNA carried in plasmids and the formation of resistance-plasmid DNA.

A necessary next step in studying the molecular biology of plasmids was the reintroduction of plasmid DNA molecules into bacteria. By isolating drug resistant plasmid DNA and placing it into bacteria, the reaction could be studied. Specifically, one could learn whether new non-drug-resistant plasmids were produced. If such reproduction occurred, plasmid DNA could be a starting point for instigating the generation of large quantities of DNA in bacteria. Initially these investigations were hampered by the method of isolation and reintroduction.

Mechanical shearing broke apart plasmid molecules, producing fragmented plasmid DNA. Fragmented resistance plasmid DNA was put into bacteria and the reaction studied. Shearing proved too imprecise a method, fragments didn't cleanly interact, and the resulting insights were minimal.

A more precise method for cutting plasmid DNA molecules was introduced in 1970 which used enzymes. An endonuclease, or enzyme, is a protein that functions as a catalyst in regulating chemical reactions in an organism. It was found that certain endonucleases naturally cut up foreign DNA which may be present in bacteria. Called restriction endonucleases, endonucleases cut DNA in precise, site-specific locations, in a way that left "sticky" ends, which were ideally suited to bond with other DNA.

If a restriction endonuclease could be adapted to cut DNA within a plasmid and the resulting plasmid were reintroduced into bacteria and it reproduced, DNA, or genetic, cloning would be achieved; the process of inducing the production of genetically identical substances.

In 1972 Dr. Cohen began a collaboration with Dr. Herbert Boyer, of the University of California, San Francisco. Dr. Boyer had demonstrated the viability of a restriction endonuclease in E. Coli, known as EcoRI. Dr. Cohen used it to clone antibiotic resistance genes in plasmids. This innovative technique, known as recombinant DNA technology, was patented by Drs. Cohen and Boyer in 1980, one of the first biotechnology patents. Before its expiration in 1997, the patent issued 461 licenses.

Shortly after his initial success, Dr. Cohen combined staphylococcus aureus DNA and E. coli DNA in an experiment proving the hypothesis that interspecies cloning was possible. This demonstration raised fears about biohazard safety and ethical concerns over cloning technology in the scientific community. In 1975 the influential Asilomar Conference on Recombinant DNA conference organized by Paul Berg was held to discuss the potential biohazards and regulation of biotechnology. A group of about 140 professionals (primarily biologists, but also including lawyers and physicians) participated in the conference to draw up voluntary guidelines to ensure the safety of recombinant DNA technology. The U.S. government, in an attempt to regulate and develop formal policies for how to conduct DNA research, created the Recombinant DNA Advisory Committee which published the Recombinant DNA Research Guidelines in 1976. Cohen argued throughout these debates that recommended containment levels for certain types of research should be lowered on the grounds that there is little risk involved. In the ensuing decades recombinant DNA technology has enhanced substances in a variety of fields, including biotechnology, medicine, medical research, food production, agriculture, and industry, and has spawned the field of genomics. This field of research intentionally also served to bring scientific research more into the public domain.

Dr. Cohen's lab has long been interested in the evolution and dissemination of antibiotic resistance, and continues to pursue these interests by investigating the biology underlying the ability of bacteria to adapt non-mutationally to antibiotic exposure and other environmental stresses via the study of plasmid inheritance, cell growth, mobile genetic elements, cancers, viruses, toxins, and drug therapy. As of 2017 the lab's research interests include how expansion of gene regions containing nucleotide repeats (NRs) has a causal role in a variety of inherited degenerative neurological diseases, including Huntington's Disease, certain spinocerebellar ataxias and muscular dystrophies, and some types of amyotrophic lateral sclerosis and frontotemporal dementia. This involves the study of mechanisms that selectively enable transcription through expanded NR regions in human genes, actions of abnormal mRNAs and proteins generated by such repeats, and efforts at treating those diseases by targeting expression of the abnormal genes.

Lastly, Dr. Cohen was a primary figure in the establishment of collaborative research with the Institute of Molecular Biology in Taipei and in helping to establish a biotechnology industry in Taiwan. For his significant scientific contributions Cohen has received the Albert and Mary Lasker Award, the Wolf Foundation Prize, the Presidential Medal of Science, and election to the Inventors' Hall of Fame, among many other honors.


Correspondence, email and electronic records, laboratory notebooks and workpapers, grant files, reports and journal articles, notes, lectures, awards, honors, and memorabilia document the academic and professional career of Stanford University School of Medicine geneticist Stanley N. Cohen. The collection comprehensively covers the many facets of Cohen's career from his early work in artificial intelligence medical diagnosis, his discovery of recombinant DNA technology, the development of laboratory safety standards, the promotion of public knowledge about science, and the ongoing focus of his lab in the areas of plasmid inheritance, cell growth, mobile genetic elements.

Series 1, Personal and Biographical (1948-2015), illustrates Dr. Cohen's academic achievements as well as his avocations. This includes certificates, diplomas, and yearbooks documenting his professional advancement, along with ephemera relating to his musical and songwriting work and the Society for Medical Friends of Wine. Several folders of clippings (1970-2013) contain articles about Dr. Cohen's career, DNA technology in general, as well as significant items of correspondence. Photographs, correspondence, and website archives for the several Cohen Birthday Symposia celebrate the successes of his lab, colleagues, and staff as well as serve as forums for invitees to discuss and present new areas of research.

Series 2, Correspondence (1968-2015) is divided into three subseries: chronological files of daily office activity (1977-1996), corporate correspondence (1970-2015), and files by personal name (1968-2011). The series also contains 65 computer discs of correspondence dating from 1979-1986 and email archives dated 1999-2016.

Series 3, Recombinant DNA (1977-1992) contains a few articles about recombinant DNA along with documentation of the process of the Cogene working group's formulation of guidelines for the safe and ethical use of cloning technology.

Series 4, Lab Administration (1972-1999) briefly chronicles some of the business and management activities of Cohen's lab. Developing protocols and procedures for the safe handling of biohazardous materials was also a significant outcome of the recombinant DNA work and the Cohen lab administration manual became a model for working safely in the lab and safely conduct experiments. Cohen's work during a sabbatical year to Taiwan University was to establishment a joint biotechnology research venture between Stanford and National Taiwan University (1991-1999) is documented through correspondence and project application files of the Chinese students working in the program.

Series 5, Lab Notebooks and Workpapers (1963-2010) contains laboratory notebooks, notes, and correspondence produced by researchers in Dr. Cohen's Stanford lab. The lab notebooks contain experiment data; Workpapers is a descriptive term Cohen uses to describe the manuscript drafts and editorial and collaborator correspondence and notes that along with lab data form the final research products. The nine notebooks produced by Dr. Cohen in this series (1963-1967) are representative examples of his postdoctoral research predate his work at Stanford; the lab notebooks for his seminal plasmid DNA work are located in the Smithsonian Museum of American History as are the physical components of the lab and equipment where the work was conducted.

Series 6, Publication Activity (1959-2016) represents scientific articles authored and co-authored by Dr. Cohen. Numbered articles total 364 but are complete only through the first 200. Those numbered beyond 200 exist variously as drafts, reprints, and correspondence. Many of the later articles exist in this collection only in digital form. This section also contains articles by Dr. Cohen (1959-2001) not represented in the numbered bibliography, and drafts and correspondence for seemingly unpublished articles (1975-1991).

Series 7, Lectures (1977-2016) consists of correspondence, brochures, announcements, notes, and speeches given by Dr. Cohen at various lectureships, conferences, symposia, and on special occasions. One section is devoted to a particular speech Dr. Cohen developed in response to the general public's reaction to the implications of cloning technology. "Fear of Knowledge" addresses the general phenomenon of fearing knowledge and relates it directly to responses to his work with recombinant DNA and stresses the need to promulgate scientific knowledge as beneficial.

Series 8, Stanford School of Medicine Genetics Department (1976-2008) contains lecture outlines, lectures, reading lists, readings, examination questions, and syllabi for courses taught by Dr. Cohen at Stanford: Clinical Pharmacology 202, Genetics 201, 202, 208, 209, Pharmacology, other miscellaneous course outlines including graduate medical education material. Dr. Cohen taught medical courses prior to being appointed professor of genetics in 1977 and was department chair.

Series 9, Contracts and Grants (1967-2010) contain guidelines and reports from various research grants Dr. Cohen's laboratory mostly involving genetic research, but also highlights the other clinical diagnostic fields Cohen worked in especially in the artificial intelligence and computational diagnostic arenas. Among the subjects studied were the evolution of plasmids through the American Cancer Society (1979-1993); ovarian and prostate cancer with the California Cancer Research Program (1998-2003); toxins in mammals and viral pathogens with the Defense Advance Research Projects Agency (DARPA); and genetics, propagation and inheritance of plasmids, genomic DNA cloning and analysis, computer-based online drug therapy monitoring/Mediphor (1970s-1986), computer intervention in clinical drug therapy/Minerva (1977-1983), computational medical diagnosis/MYCIN research with Edward Shortliffe, and tumor suppression gene with NIH (1971-2002). The series also contains an alphabetical list of funding sources.

Series 10, Material Transfer Agreements (1968-2006) contains records of agreements and transfers made of plasmid DNA strains requested for cloning, documentation of the development of terminology and procedures, and requests for transfers of random homozygous knockout, a mutated gene made to replace a normal genome to study its functions in a live organism.

Series 11, Cohen/Boyer Patent (1972-2003) contains legal and administrative documents for preparing recombinant DNA patent applications and the subsequent management of royalties and technology usage rights. The materials include legal discussions and debates about the Cohen/Boyer original patent application, technology transfer, royalties, and material usage agreements. It also includes the original patent certificate.

Series 12, Travel, Meetings, and Seminars (1976-2016), contains brochures, proceedings, agendas, and notes from professional scientific meetings, conferences and symposia Dr. Cohen attended. Among the most frequently attended were meetings with the National Academy of Sciences/PNAS, Gordon research conference, American Society for Microbiology, Institute of Molecular Biology (Taiwan), Federation of American Societies for Experimental Biology, Defense Advanced Research Projects Agency (DARPA), and Singapore Economic Development Board (EDB).

Series 13, Memberships and Awards (1955-2016), holds certificates, plaques, and artifacts presented to Dr. Cohen. Notable among these are honorary doctorates from Rutgers University and the University of Pennsylvania, the Lasker Award, the Shaw Prize, the Wolf Foundation Prize, the National Medal of Science, the National Medal of Technology, and certificate of induction into the Inventors' Hall of Fame. Certificates and other documentation represent Dr. Cohen's membership in various medical societies and academies.

Index Terms

These terms are indexed in the National Library of Medicine's online catalog LocatorPlus. Researchers wishing to find related materials should search the catalog using these terms.

    MESH Subjects

    • Biotechnology
    • Containment of Biohazards
    • Diagnosis, Computer-Assisted
    • DNA, Recombinant
    • Genetics
    • Genetic Engineering
    • Genomics
    • Government Regulation
    • Laboratories--organization & administration
    • Plasmids
    • Technology Transfer
    Personal Names

    • Boyer, Herbert W.
    • Chang, Annie Chuan-Yuen
    Corporate Names

    • Stanford University. School of Medicine
    Geographic Names

    • California

    Series Descriptions

    Series 1: Personal and Biographical, 1948-201611Rifles for Washington [first prize award for DAR essay contest: 'Atomic Energy - for War or Peace'], 21 June 194812-3 The Periscope of 1952 - Perth Amboy High School yearbook, 195214 United Synagogue Youth Second National Convention program booklet, 195215 Perth Amboy High School Class of 1952 - 35th reunion booklet, 198716 The Nineteen Fifty-Six Scarlet Letter - Rutgers yearbook, 1956Map Drawer 243 Rutgers University Bachelor of Arts degree - diploma, 6 June 195617 Scope 1960 - University of Pennsylvania School of Medicine yearbook, 1960Map Drawer 242 University of Pennsylvania - diploma, 15 June 196018 University of Pennsylvania Commencement Program, 15 June 196019 "Only You" written by James J. Kriegsmann and Norman Stanton (Stanley N. Cohen) - sheet music, advertising flyer, 1960110 Achshav 25th anniversary yearbook, United Synagogue Youth, 1975111 "DNA cloning: a personal perspective", by Stanley Cohen, 1988112 The Search For Life: Genetic Technology in The Twentieth Century - Smithsonian exhibit pamphlet, 16 December 1987222 The Search for Life: Genetic Technology in the Twentieth Century - invitation - [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 10 November 1987214 Letter from Stanford President Donald Kennedy [in Newspaper and magazine clippings, press releases, brochures 1978-2004], 30 December 1982 Certificates Map Drawer 243 Reserve Corps of the Public Health Service - assistant surgeon appointment, 20 June 1961Map Drawer 241 Mount Sinai Hospital - July 1, 1960 to June 30, 1961 internship certification, 30 June 1961Map Drawer 241 Reserve Corps of the Public Health Service - senior assistant surgeon certification, 1 July 1962Map Drawer 241 License to Practice Medicine and Surgery in the Commonwealth of Pennsylvania, 9 January 1964113 National Institute of Arthritis and Metabolic Diseases - certificate of completion of clinical associate duties, 30 June 1964Map Drawer 241 North Carolina Board of Medical Examiners - certificate of reciprocity, 24 July 1964Map Drawer 241 Duke University Medical Center and Affiliated Hospitals - certificate of completion of senior assistant residency duties, 30 June 1965Map Drawer 241 The Department of Professional and Vocational Standards Board of Medical Examiners - certification, 7 October 1968Map Drawer 243 Certificate of Appreciation for Acting Chairmanship of SOM Department of Genetics, 1986 Cohen Birthday Symposia 114-15 60th birthday symposium and celebration [talk, photographs, notes, cards], 199596 60th birthday - photograph album, 1995116 70th birthday, 2005117 Biotechnology in the 21st Century: a Scientific Symposium Honoring Stanley N. Cohen - photograph album, 2005118 Cohen 75th birthday symposia - "35 years of DNA Cloning", 2010119 Cohen 75th birthday symposia - guest book of congratulations, 2010 Business Activities 120 Cetus and other financial documents, 1976-1981121 Medication Services, Inc. - business plan, 1987127 New Brunswick Scientific Co., Inc.'s Universal Membrane Filtration Apparatus - brochure [in Newspaper and magazine clippings, press releases, brochures 1970-1978], undated Society of the Medical Friends of Wine 122 Wine tasting at the 1987 Miami Winter Symposium - program, 10 February 1987123 50th Anniversary - group photograph, January 1989124 Tasting of recently released California wines - brochure, 14 November 1990125 One Hundred Seventy-Fourth quarterly dinner - brochure, 12 June 1991 Clippings and articles about Dr. Cohen 126 Wellcome News, Spring 1970127-29 Newspaper and magazine clippings, press releases, brochures, 1970-1978129 Cathy - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 20 January 1978129 Carol Katz - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 20 January 197821-3 Newspaper and magazine clippings, press releases, brochures, 1970-199424 Newsweek, 17 June 197425 Readers Digest, December 197526-7 Magazines and memorabilia, 1975-197928 Atlantic Monthly, February 197729 Time, 18 April 1977210 Parents Magazine, November 1977211 Stanford Magazine, Fall/Winter 1977212-14 Newspaper clippings, letters, news releases, 1978-2004215 Newsweek, 17 March 1980216 Time, 30 June 1980217-20 Magazines and memorabilia, 1980-1990221 Scientific American, September 1981222-23 Newspaper clippings, magazine articles, 1983-200131 Stanford Medicine, Fall 198432 National Geographic, December 198433 "Le mystique du génie génétique" - by Gilbert Charles, L'Express Aujourd'Hui, 198834 The Life Revolution, a UK Channel 4 television documentary - episode summaries, 1988-198935 "First cloner" - by Lisa Bain, Penn Medicine, Winter 1990-199136-8 Magazines and memorabilia, 1991-200039 Center Focus, Summer 1993310-11 Newspaper clippings, brochures, memorabilia [photographs], 1993-1999312 Center Focus, Fall 1994313 The Pennsylvania Gazette, June 1995314-16 Newspaper clippings, brochures, memorabilia [including The Stanley N. Cohen, M.D., Endowed Scholarship update, April 2007], 2001-2013317-18 Magazines and memorabilia, 2001-2015 Miscellaneous 319 In The Genetics Lab at Stanford I, II, and III - artwork signed by Chris Ranes, 1981320 Card from Cloris and Herman, 22 August 1981321 Letter from congresswoman Anna G. Eshoo to Dr. Cohen re: Stanford Dean's Medal, 26 September 201196 Framed illustration of design etched in granite on bench panel 09_15 "Recombinant DNA", 2012Map Drawer 243 Framed cover of Proc. Natl. Acad. Sci., 3 August 2004 Photographs 322 Stanley N. Cohen lab bench exhibit - photograph of bench on display at the Smithsonian, 2011 January 5323 Stanley Cohen - postdoctoral fellow, 1965324 Stan photos - Stanford publicity photos, c.1980s325 Lab party at Stan's house, c.1990s326 [Dr. Cohen socializing], 1995327 To Stan from Phil - trip to Taiwan photos, 17 July 1997 Winding Your Way Through DNA symposium, 25-26 September 199241 Program booklet 42 "Stories from the scientists" teacher's guide Audiovisual 4 "New ways of searching for tumor suppressor genes", Stanley N. Cohen; "Molecular markers. . . ", Simon Silver. Wayne State University, Frontiers in Molecular Medicine: Tape 2 - [vhs videocassette], undated4 "Fishing for Genes", Sidney Brenner; "Molecular Markers of Pancreatic Carcinoma and their Clinical Correlations", Vainutis Vaitkevicius. Wayne State University, Frontiers in Molecular Medicine: Tape 3 [vhs videocassette], undated4 Interviews with Watson & Cohen. Danmarks Radio - [2 vhs videocassettes], undated4 "Biotechnology" NHK TV special, Japanese TV [featuring intro by Cohen] - [vhs videocassette], [1998]4 The Life Revolution [documentary series] [6 vhs videocassettes], 19894 Bernard Cohen Memorial Lecture, Dr. Steven McNight - [vhs videocassette], 19 March 19914 Our Fragile Fortress - Dr. Stanley Cohen's interview [with thank you note] - [vhs videocassette], 22 April 19944 Innovative Lives [interactive], Lemelson Center, National Museum of American History, Smithsonian Institution - [cdrom, QuickTime format], 19964 The Remarkable 20th Century, volume eight: 1970s - [vhs videocassette], 20004 Eureka! The 20th Century's Top 15 Inventors. A&E Biography - [vhs videocassette], 20024 Shaw Prize special: Professsor Stanley N. Cohen [biography of Cohen and Boyer discovery] (English and Chinese versions) - [vhs videocassette], 20044 Sphygmomanometer (blood pressure meter) used by Stanley N. Cohen in medical school at the University of Pennsylvania, 1958-19604 Electronic records copied from hard drives [3 usb thumb drives] Born digital Biotechnology Heritage Award [mp4], 2016Born digital Archive-It web archive, top results for "Stanely N. Cohen" Google search conducted by HMD staff; Stanford Lab website ; Gabriel project; 80th birthday symposium, 2017

    [view online]

    Series 2: Correspondence, 1968-2016328-29 Requests: write manuscripts/articles, 1977-1995330 Binder #1 - 0002A, 0007, 0105A, 0122A, 0004A, 0011, 0106A, 0006, 0012A, 0107A - [10 8" computer discs], 1979-1985331 Binder #2 - 0023A, 0125A, 0129A, 0132A, 0140A, 0143A, 0205A, 0206A, 0213A, 0217A - [10 8" computer discs], 1980-198451 Binder #3 - 0218A, 0225A, 0228A, 0232A, 0220A, 0226A, 0229A, 0221A, 0227A, 0231A - [10 8"computer discs], 1982-198552 Binder #4 - 0002C, 0005C, A2125, 0009C, 0018C, 0003C, 0006C, 0012C, 0004C, 0007C, 0014C - [10 8"computer discs], 1983-198553 Binder #5 - 0234A, 0237A, 0245A, 0235A, 0238A, 0246A, 0236A, 0239A - [8 8" 8computer discs], 198454 Binder #6 - 0011C, 0023C, 0030C, 0015C, 0024C, 0033C, 0022C, 0025C, 0034C - [9 8" computer discs], 198555 Binder #7 - 0016C, 0207A, 0031C, 0137A, 0224A, 0001B, 0141A, 0243A - [8 8"computer discs], 1986 Chron files 564 January-24 May 19775724 May-29 September 1977584 October-20 December 1977598 June-29 September 19785101 October-15 November 197851116 November-31 December 19785121 January-31 March 19795131 April-12 June 197951412 June-23 August 19795154 September-31 December 19795162 January-7 April 19805177 April-19 June 198051819 June-24 September 198051924 September-31 December 1980616 January-19 February 19816219 February-31 March 19816331 March-9 July 19816414 July-10 September 19816511 September-29 December 1981664 January-29 April 1982674 May-3 June 1982688 June-13 August 19826913 August-31 October 198261025 October-12 November 19826114 January-11 April 198361212 April-31 May 19836132 June-28 July 19836141 August-2 December 19836152-30 December 1983616January-April 1984617May-August 1984618September-December 1984619January-April 198571May -August 198572September-December 198573January-April 198674May-August 198675September-December 198676January-June 198777July-December 198778January 198879February 1988710March 1988711April 1988712May 1988713June 1988714July 1988715August 1988716September 1988717October 1988718November 1988719December 1988720January 1989721February 1989722March 1989723April 1989724May 1989725June 1989726August-December 1989727January-March 199081April-May 199082June-July 199083July-September 199084October-November 199085-6January-June 199187-8July-December 199189-10January-June 1992811-13July-December 1992814-16January-June 1993817-19July-December 199391-21995934 January-4 April 1996 Corporate Entities 94 American Broadcasting Company, 198195 Beckman Instruments, 1981-1982 Burroughs Wellcome 96-9 General, 1970-1988910 Interferon shipments, 1979-1981911-12 Interferon I, 1979-1980913 Scholar Award, 1968-1987914 Center for Science in the Public Interest, 1981 Cetus 213 "Cetus, a genetics engineering firm, plans initial public offer of 5.2 million shares" Wall Street Journal - clipping [in Newspaper clippings, letters, news releases 1978-2004], 14 January 1981915-16 Biotechnology Award, 1987-1989917 Flukes - Cetus' tenth anniversary issue, April 1982918 Ronald E. Cape, 1984-1985919 City of Medicine awards, 1996920 Committee of Concerned Scientists, Inc., 1984921 Czeck affair, 1971-1972922 European Scientific Action Group for Nuclear Safety, 1986923 Food and Drug Administration (FDA), 1973-1986924 Human Gene Mapping Library, 1989-1990925 Industrial Biotechnology Assoc., 1987926 Life Sciences Foundation - LSF magazine, 2014-2015927 Medispan archive, 1991-1995928 Meridian Instruments, Inc., 1989929 Modern Maturity, 1995930 Monsanto, 1987931 MSI, 1985-1987932 National Research Council Commission on Life Sciences, 1995933-34 National Science Foundation, 1985-1990935 Nova, 1976-1977936 Nuclear disarmament, 1984937 Office of Technology Assessment Project (mapping of human genome), 1986-1987938 Paid prescriptions, 1971939 Robert J. and Claire Pasarow Foundation Medical Research Awards, 1989940 People to People Citizen Ambassador programs, 1986941 Pfizer, 1977-1982942 Promis, 1977943 Society for Developmental Biology, 1989944 Synthetic oligonucleotides, 1992-1993945 Technology transfer, 1989 Individuals 946 A - General, 1977-1991947 Adams, Camellia W., 1987-1993101 Adams, Camellia W. (cont'd), 1987-1993102 Anderson, E. S., 1969-1976103 Andre, Charles P., 1986-1992104 Apirion, David, 1991105 Axline, Stanton G., 1974-1980106 B - General, 1980-1995107 Bajorek, Teresa, 1992-1994108 Barchas, Jack, 1982-1985109 Bastia, Deepak, 1990-19911010 Baumler, Ernst, 19811011 Beachy, Philip A., 19801012 Beale, Dr. John (Burroughs Wellcome), 1979-19801013-16 Beatty, J. Thomas, 1979-19961017-19 Beaucage, Serge, 1985-19911020-25 Belasco, Joel, 1980-19921026 Berg, Douglas E., 19811027-30 Bibb, Mervyn, 1977-19941031-35 Biek, Donald P., 1982-19921036 Birnstiel, Max L., 1981-19831037 Bjornsson, Thorir, 1972-1978111-2 Blair, Deeda, 1986-1990113-9 Blaschke, Terry, 1973-19911110 Blau, Helen, 1986-19961111 Bloomfield, Janine, 19841112-13 Blum, Robert, 1976-19861114 Bollen, Mathieu, 19951115 Boothroyd, John, 19821116 Botstein, David, 1979-19961117 Boyer, Herbert, 1973-19951118-19 Brace, Art, 1981-19931120-23 Brasch, Michael [3.5 computer disc], 1986-19961124-26 Brenner, Daniel, 1985-1992121 Brenner, Daniel (cont'd), 1985-1992122 Brevet, Jean, 1972-1983123 Briggs, Russ, 1972-1975124 Brinton, Charles, 1970-1971125 Brothers, Lynda, 1973-1986126 Brown, Arnold, 1971-1981127 Brown, Byron William, 1976-1990128 Brutlag, Simone Manteuil, 1993-1995129-11 Bujard, Hermann, 1977-19971212 Bush, Diane E., 19761213-14 C - General, 1980-1996 1215-16 Cabello, Felipe C., 1996-1998 [1]1217-21 Calos, Michele, 1981-19871222 Cann, Howard, 1978-19841223 Carpenter, Karen J., 1985-19911224 Carpousis, A. J., 19961225 Carrell, Laura, 19901226-29 Casabadan, Malcolm, 1975-19881230 Case, James, 19801231 Caspari, David, 1981-19891232-33 Cavalli, Luca, 1978-19901234-35 Chang, Poa-Chun, 1990-1995131 Chang, Poa-Chun (cont'd), 1990-1995132-3 Chang, Shing, 1975-1985134 Chang, Wen, 1996135 Chao, Chuck, 1990-1996136 Chater, Keith, 1983-2000137 Chavez-Pardo, Rodolfo [photograph], 1972-1980138 Chen, Carton, 1990-1996139 Chen, Jianzhu, 1985-19861310 Cheng, Te-Fang Delfine, 1985-19881311 Chou, Joany, 1975-19931312 Choudary, Prahbakara V., 1983-19851313 Chretien, Michel, 1979-19931314 Chung, Bon-Chu, 1995-19961315 Clancy, Suzanne, 1982-19901316 Claverie-Martin, Felix, 1995-19961317 Clayton, David A., 1970-19961318 Clewell, Don, 19851319 Cochet, Madeleine, 1978-19811320 Cohen, Gerald, 1994-19961321 Cohen, Philip, 1995-19961322-23 Conley, Dierdre, 1987-19961324 Cortese, Riccardo, 19821325 Cox, David, 19921326 Crater, Dinene, 1996-19971327 Cuatrecasas, Pero, 1981-19821328-29 D - General, 1979-1996 1330 Davies, Julian, 1991-19981331 Davis, Randy, 1973-19771332 Delappe, Irving, 1973-19761333 Demain, Arnold L., 19801334 Donahue, Tom, undated1335 Doyle, Dierdre [3.5 computer disc], 1986-19991336 Driscoll, Janie, 1991-19941337 Dubridge, Robert, 1981-19831338 E - General, 1982-19901339 Erlich, Henry, 1977-19841340 Ermakov, Grigory, 19961341 Espinosa, Manuel, 19961342-43 F - General, 1981-1995 1344-46 Falkow, Stanley, 1977-19891347 Federman, Daniel, 1973-19771348 Feinberg, Laurie, 1970-19851349 Feitelson, Jerald S., 1978-19791350 Flaggs, Gail, 1990-19911351 Flowers, April, 1987-19881352 Fraley, Cres, 1995-1997141 Francke, Uta, 1988-1995142 Franklin, Rosalind, 1998-1999143 Funnell, Barbara, 1994-1995144-5 G - General, 1974-1996 146-12 Gabain (von), Alexander, 1977-19961413-17 Gaggero, Christina, 1993-1996 1418 Gallo, Robert, 1986-19881419 Ganesan, Adayapalam T., 1978-19911420 Gazdar, Adi, 19811421 Gelfand, David, 19791422 Gershon, Elliot, 1981-19831423 Geryk, Donna, 1986-19891424-31 Gilbert, David, 1982-1996 151-4 Gilbert, David (cont'd), 1982-1996155 Glazner, Fred, 1981156 Gold, Lynn, 1981-1982157 Goldstein, Avram, 1980-1988158-9 Gossard, Francis, 1980-19881510-11 Grant, Sarah, 1981-19941512 Grobstein, Clifford, 19771513 Gullberg, Martin, 19961514-16 Gustaffson, Petter, 1977-19921517-18 H - General, 1980-1996 1519 Haase, Steven, 19851520 Hackett, Christopher, 1998-19991521 Hagedorn, Curt, 1995-19961522-23 Hagege, Juliette Martine, 1991-19961524 Hakanson, Rolf, 1982-19831525 Hamm, Thomas, 19861526 Hanawalt, Philip C., undated1527 Hannigan, John F., Jr., 1973-19771528 Hansten, Phil, 1971-19761529 Hedges, Robert, 1975-19881530-31 Helinski, Donald R., 1975-1995 1532 Hendrich, Brian, 19911533 Henning, Karla, 1986-19941534 Herbert, Ed, 1980-19821535-36 Hernandez, Rachel, 1988-19931537-38 Herzenberg, Leonard, 1971-19861539 Herzenberg, Leonard (Brenner/Nolan dispute), 1987-1990 [1]1540 Herzenberg, Leonore, 1980-19871541 Ho, Coy Choke, 1980-19931542 Hoffman, Barbara, 19961543-45 Hoffman-Liebermann, Barbara, 1978-1990161 Hogness, David, undated162 Hollister, Leo, 1973-1976163 Hood, Lee, 1987-1989164-6 Hopwood, David, 1994-1996167 Hsu, Charles, 1979-1984168 Hsu, Leslie, 1971-1972169 Huang, Hongjin, 1994-19971610 Huang, Huei-Jen Su, 1989-19911611 Hunn, Gilbert, 1970-19791612 I - General, 1990-19961613 Illa, Robert, 1972-19941614 Ingmer, Hanne, 1989-19961615 Inloes, Doug, 1982-19841616 Israel, Alain, 1979-19921617-18 J - General, 1982-1995 1619 Jain, Chaitanya, 1995-19961620-22 Jaurin, Bengtake, 1980-19881623 Jaurin, Kerstin R. V., 1983-19841624 Johnson, Jacki, 1981-19841625 Johnson, Matti, 1982-19831626 Joklik, William K., 1981-19851627 Joseph, Loren, 1976-19781628-29 K - General, 1980-1996 1630-31 Kaberdin et al., 1994-19961632 Kan, Yuet Wai, 1985-19861633 Katz, Leonard, 1990-20011634 Kaufman, Randal J., 19811635-36 Kedes, Larry, 1974-19921637-38 Kendall, Kevin, 1983-19961639 Kieser, Tobias, 19911640 Kim, Eung-Soo, 1993-1996171-5 Klug, Gabriele, 1985-1997176 Knopf, Ulrich C., 1975-1977177 Kondo, Jing, 1984-1985178-10 Kopecko, Dennis, 1971-20111711-16 Korn, Laurence, 1980-19861717-18 Kretschmer, Peter J., 1973-19891719 Krysan, Patrick, 1990-19931720 Kunst, Frederik (Frank), 1977-19811721 Kurth, Janice, 19881722 Kwan, Catherine, 1995-19961723-24 L - General, 1976-19961725 Laird, Alan, 1979-19891726 Lander, Eric, 19961727-28 Lederberg, Esther, 1973-1978181-3 Lederbeg, Joshua, 1976-1993184-7 Lee, Stephen, 1984-1991188-11 Lemaux, Peggy G., 1976-19911812 Levinthal, Elliott, 1978-19841813 Levy, Ronald, 19861814 Lezhava, Alexander, 1995-19961815 Liaw, Yen-Chywan, 19961816-18 Liebermann, Danny, 1982-19891819-22 Liebermann, Dan and Barbara (Hoffman), 1992-19951823-26 Li, Limin, 1989-20011827 Lin, Bai Ling, 19971828-29 Lin-Chao, Sue, 1986-1996 191-13 Lin-Chao, Sue (cont'd) [3.5 computer disc], 1986-19961914 Linebaugh, Catherine, 1981-19821915 Lizardo, Esteban, 19841916 Lockwood, Steve, 1979-19801917 Losick, Richard, 1984-19891918 Lovett, Paul, 19781919 Lucio, Simon, 1981-19821920-21 M - General, 1978-19971922 Machbitz, Jack, 1973-19761923 Mackie, George, 19951924 Malamy, Michael, 1974-19761925 Mandoli, Dina, 19811926 Mangini, Richard J., 1975-19841927 Mansour, Tag, 1979-19811928 Marie, Helene, 19951929 Marmur, Mildred, 1991-19921930 Marquez, Leticia, 1981-19831931 Marrs, Barry, 1976-19821932 Masters, Millicent, 1993-19941933 Mathews, Kathryn, 19831934-35 McClintock, Barbara, 1980-19851936 McCoubrey, Annette, 1971-19791937-42 McDevitt, Hugh O., 1980-1996201-3 McDowall, Kenneth, 1989-1996204 McKee, Constance, 1989-1993205-7 Meacock, Peter A., 1975-1987208-11 Melmon, Kenneth, 1977-20022012 Merigan, Thomas E., 1980-19972013-14 Michaels, Alan, 1980-19822015 Misfeldt, Dayton, 1982-19832016 Mitchell, Dorothy, 1985-19932017 Mitchell, Rodney, 1985-19862018 Miczak, Wei, Lin-Chao, 1995-19962019 Mondy, Russell, 19832020 Montano, Monty, 19892021 Moore, Terrence, 1973-19852022-23 Morrell, Joan, 1975-19842024 Mortelmans, Kristien, 19842025 Murphy, Shari, 1981-19822026 Myers, Richard M., 1985-19962027-28 N - General, 1981-1996 2029 Nakanishi, Shigatada and Numa, Shosaku, 1978-19822030 Narang, Sarah, 1975-19792031 Narro, Martha, 1984-19892032 Nebert, Daniel W., 1980-19902033 Nicolet, Charles, 1984-19872034 Nisen, Perry, 1975-19842035 Nishimura, Tad, 1972-19732036 Noguchi, Toshitada, 1993-19962037 Nolan, Garry P., 1984-19882038 Nordstrom, Kurt, 1980-19832039 Novick, Richard, 1977-19952040 Nunberg, Jack H., 19782041 O - General, 1976-19922042 Ogawa, Joy, 19832043 Oishi, Michio, 19952044 Oliver, Noelynn, 1981-19822045 O'Malley, Karen, 19802046-48 Omer, Charles, 1980-1999 211 O'Reilly, Robert, 1977212 Ott, Russell, 1981-1990213-4 P - General, 1981-1996 215-6 Pandza, Kenan, 1995-1996217 Pennaccio, Len, 1994-1995218-10 Pettis, Gregg, 1988-19962111 Phillips, Steve, 1969-19702112 Platt, Terry, 1983-19852113 Podlone, Michael, 1969-19742114-15 Ptaschne, Kay A., 1971-19752116-17 R - General, 1979-1996 2118 Rabourdin-Combe, Chantal, 1980-19842119 Ramu, Avner [photograph], 1972-19762120 Ranes, Monica, 1981-19872121-22 Ravnan, Britt, 1983-19932123 Regnier, Philippe, 1994-19952124 Remington, Jack, 1980-19882125 Resnekov, Orna, 19912126 Ringold, Gordon, 1977-19822127 Risch, Neil, 1993-19942128 Robertson, Channing, 1980-19822129 Robinson, Harriet, 1980-19962130-31 Robinson, W. S., M.D., 1995-19962132 Robledo, Basil, 19832133 Rogler, Charles E., 1974-19792134 Romero, Edward, 1982-19832135 Ronquillo, Ricardo, 1983-19842136 Rosenstock, Irwin M., 1974-19772137 Rothenberg, S. Michael, 19922138 Rutherford, Philip C., 19932139 Ruvkin, Gary B., 1984-19852140-41 S - General, 1982221 Sachs, Leo, 1982222 Salkinoja-Salonen, Mirja, 1980-1981223 Sameshina, Harry, 1981-1982224 Schell, Jeff, 1975-1990225 Schimke, Robert T., 1978226-9 Schottel, Janet L., 1976-19942210 Sgaramella, Vittorio, 1976-19912211 Shapiro, Lucille, 1988-19962212 Sharp, Phillip, 1970-19712213 Sharrer, Terry, 19962214 Shaw, William V., 1981-19882215 Sherratt, David J., 1988-19932216-17 Shiffman, Dov, 1988-19952218-20 Shortliffe, Edward H., 1971-19902221 Siddiqui, Aleem, 1979-19812222 Silver, Rich, 1968-19762223 Smith, Laurie, 1972-19752224 Smith, Mark R., 19952225 Smith, William, 1981-19822226-28 Sninsky, John J., 1975-19852229-31 Spector, David Martens, 1977-19992232 Sobottka, Elizabeth, 1982-19842233-36 Stein, David, 1981-1993 2237 Steinman, Larry, undated2238 Stollar, David, 1975-19822239 Stuart, Dorsey, 1980-19812240 Swanson, Robert, 1998-20012241 Sweetser, David, 19912242 Szalay, Aladar, 19862243 Szybalski, Waclaw, 1980-1996231-2 T - General, 1980-1995 233-4 Tai, Julie Tsu-Ning, 1988-1997 235 Tatro, David, 1974-1982236-8 Taylor, Dean, 1975-1997239 Taylor, Sandra, 19822310-11 Timmis, Kenneth N., 1972-19842312 Tomkins, Lucy S., 19832313 Tooze, John, 19802314-15 Troutt, Anthony B., 1984-19882316 Ts'o, Dr.Paul O. P., 1993-19962317-19 Tu, David, 1975-19882320-21 Tucker, William T., 1979-19852322 U - General, 1973-19912323-25 Uhler, Michael D., 1980-19882326 V - General, 1971-19862327 Van Bree, Mark, 1982-19842328 Van Den Berg, David, 1985-19952329 Van Embden, J., 1971-19732330 Van Zanten, Pamela, 19942331-32 Vogtli, Martin, 1987-19942333 Vollrath, Doug, 19932334-35 W - General, 1980-1996 2336 Wa, Xian, 19962337 Wade, Nicholas, 1978-19842338 Wagner, Gerhart, 19942339 Walker, Daphne K., 1976-1978241-5 Wallace, Douglas, 1979-1983246 Wang, C. C., 1992-1993247 Wang, Fubao, 1992-1996248 Wang, Maureen, 1990-1995249 Weissman, Sherman, 1981-19832410 Westpheling, Janet, 19942411 Wheeler, Catherine, 19812412 Willetts, Neil, 19812413 Wolfsen, Ada R., 1980-19812414 Wraith, Sharon, 1975-19792415 Wu, Ray, 1978-19992416-20 Xu, Feng Feng, 1989-19962421-22 Y - General, 1979-1994 2423 Yang-Yen, Hsing-Fang, 19962424-26 Yarden, Anat, 1988-19962427 Yasuda, Jun, 19962428 Yoder, John, 1981-19842429 Yosten, Linda, 19732430 Yu, Victor, 1974-19782431-32 Z - General, 1980-19962433 Zabielski, Jan, 1973-19752434 Zilinskas, Raymond, 19822435 Zweiger, Gary, 1987-1995Born digital Email archives [21.2 GB], 1999-2016
    Cohen's emails from his sncohen@stanford.edu Stanford account that he sent to/forwarded to and administered by his Administrative Assistant, not those from Cohen's computers and managed by Cohen. These largely represent Cohen's administrative and lab activities, contrasted to the emails he personally managed on his same Stanford account.

    Series 3: Recombinant DNA, 1977-1992128 Stanford University Medical Center News Bureau release of adaptation of Cohen Publication #77: Cohen, S.N. Recombinant DNA: Fact and fiction. Science 195:654-657 [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 14 February 1977129 Edward M. Kennedy - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 13 November 19772436-37 Cogene - Sagene, 1979-19922438 Course on Molecular Genetics, Nairobi, 1985 Working group 2439 Foreign guidelines, 1977-1983251-4 Foreign guidelines, 1977-1983255-6 Guidelines questionnaire, 1977-1979257-10 Guidelines questionnaire - primary responses, 1977-19802511 Risk assessment, 1977-19792512-14 First report to COGENE from the working group on Recombinant DNA guidelines, 1979-1981 Series 4: Lab Administration, 1972-19992515-18 Commercial requests RHKO, 1996-20002519 Graduate study syllabus, 1979-1986128 SNC memo re Ulrich Knopf cloning chloroplast DNA of chlaymdomonas without permission [in Newspaper and magazine clippings, press releases, brochures 1970-1978], July 19762520 Protocol for laboratory animals, 1981-19972521 Safety, 1979-1992 Cohen Lab Procedure Manual 2522-23 A manual of procedures used in the S. N. Cohen Laboratory, Department of Genetics, Stanford University, March 19882524-26 A manual of procedures used in the S. N. Cohen Laboratory [Copy showing changes made], 1988 Equipment manuals and advertising 261 The Bionet Resource (Bionet satellite program), 1985-1989262-3 Densitometer: quick scan R and C SN RID 180108 SP, 1977-1993264-5 Electron microscopes, 1972-1981 Stanford-Taiwan Programs 266 Other Stanford Faculty, 1997267 Proposal letter, 1997268 Trip funding, 1997269-13 Taiwan communications - SND/JD, 1992-19972614 Taiwan Institute of Medical Biology (IMB), 1994-19982615 Taiwan IMB/NSG proposal, 1993-19942616 Taiwan IMB review/recommendations, 19942617-18 Taiwan Institute at Stanford, 1991-1992 2619-20 Stanford-National Taiwan University steering committee, 1992; 1995-19982621 NTU-Stanford meeting - Taiwan, 2021 October 19972622 Brown, Patrick, 19972623 Chao, C.K., 1996-19982624 Chen, Ding-Shinn, 1997-19982625 Greenberg, Harry, 1997-19982626 Kierkegaard, Karla, 19972627 Lai, Ming-Yang, 19972628 Lee, Lin-Shan, 19972629 Lin-Chao, Sue, 1996-19982630 Mocarski, Edward, 1997-19982631 Sarnow, Peter, 19972632 Shen, C.-K., 19972633 Sung, Mei-Hwa, 19972634 Wang, Patrick, 1997-19982635 Wu, Cheng-Wen, 19992636 Yeh, Shiou-Hwei, 1997 Series 5: Lab Notebooks and Workpapers, 1963-2010 Bao, Kai 2637 Notebook files [CD-R], 1999-2004 Lab notebooks 2638 Genetics - 1, 17 June 1998-12 August 1999271 Genetics - 2, 14 August 1999-6 February 2001272 Genetics - 3, 11 December 2000-12 December 2001273 Genetics - 4, 15 December 2001-1 May 2002274 Genetics - 5, 8 April-31 December 2002 Bernstein, Jonathan Notes 275-7 X-rays, 1989-1999278 Notebook files [CD-R], 1996-2002 Lab notebooks 279 Untitled, 19962710 Untitled, 1998-20032711 WTof RWE; Smb is WT; Rapid LB time course; B103 backup [5 CD-R, 1 zip disc], 2000-2001 Biek, Donald P. - Notes 2712 par slides, undated2713 Miscellaneous, undated2714 Streptomyces transposons, 1983-19842715-16 par, 1983-19842717 Streptoymces transposons - promoter selections, 1983-19852718 Tn10 hops looking for pma mutants, 1984-19852719 184 +- par stability, 1984-19862720 Effect of rec mutations on pmaA plasmid instability, 1984-19862721 pmaA complementation, 1984-19862722 Isolation par- point mutants of psc101, 1984-19862723 Untitled, 1984-1987281-3 pmaB, C (him D, A), 1984-1988284 Untitled, 1984-1988285 pmaA poster - Gordon conference, 1985286 pmaA multimer gels, 1985287 Recombination tests in pmaA, 1985288 Tn3 transposition in pmaA, 1985289 Plasmid studies in rec[ ] -pmaA, 19852810 Resolution of plasmid multimers in pmaA (+- Tn3 promoted), 19852811 pmaA sectoring and tet dependent sectoring, 1985-19862812 Untitled, 1985-19862813 psc101 stability studies, 1985-19862814 Constructing an SopABC derivative of psc101 par, 1985-19862815 Untitled, 1985-19872816 Chromosomal mutations affecting psc101 cmp, 1985-19882817 pma-10 mini-tet studies, 1985-19882818-19 recD paper, 19862820 Notes, 1986-19872821 Current, 1986-19882822 RNase II assays, 19872823 Untitled, 19872824 rep fusion studies, 1987-19882825 Involvement of IHF in the maintenance of plasmid psc101 in E. coli, 19882826 Strains put in sc collection by D.B., 19882827 Topoisomerase assays, 19882828-29 Final versions of IHF papers, 1988-19892830 pma-10 studies in progress, 1988-19892831 TC promote exps, 1989-19902832 or IHF +- par - transformation and stability studies, 1989-19912833 REP (alternate gyrate site) studies, 1989-19912834 Effect of GUR- on or IHF, 1989-1991 Brasch, Michael A. - Notes 2835-36 SLP1 integration, 1987-1993291-6 SLP1 replication, 1987-1993297 SLP1 replication, 1993298-11 PLJ101 replication, 1990-19912912-13 SLP1 1nt and Xis, 1990-19922914-16 PLJ101 replication, 1990-19932917 PLJ101 replication, 1990-1993301 PLJ101 replication (cont'd), 1990-1993302-4 Untitled, 1992-1993 Chang, A.C.Y. (Annie) Lab notebooks 305 1, 8 November 1976-7 April 1977306 2, 7 April-16 August 1977307 1, 17 November 1977-7 April 1978308 4, 1 December 1977-16 April 1978309 5, 16 April-28 July 19783010 6, 28 July 1978-5 January 19793011 7, 8 January-3 July 19793012 8, 3 July-29 November 19793013 9, 29 November 1979-29 March 19803014 10, 1 April-15 September 19803015 11, 15 September 1980-26 January 19813016 12, 26 January-6 June 1981311 13, 11 June-10 November 1981312 14, 10 November 1981-3 March 1982313 15, 4 March-19 June 1982314 16, 19 June-20 September 1982315 17, 21 October 1982-24 March 1983316 18, 24 March-30 September 1983317 19, 7 October 1983-9 April 1984318 20, 10 April-16 November 1984319 25, 13 July 1988-17 August 19893110 Untitled, 21 August 1989-17August 19903111 Untitled, 20 August 1990-21 October 19913112 Untitled, 23 October 1991-5 October 1992321 Untitled, 10 October 1992-3 May 1994322 Untitled, 11 May 1994-6 September 1995323 Untitled, 11 September 1995-21 January 1997324 Untitled, 23 January 1997-3 June 1998325 Untitled, June 1999-March 2000326 Untitled, 29 March 2000-22 May 2001327 Untitled, 23 May 2001-23 October 2002328 Untitled, 24 October 2002-25 March 2004329 Untitled, 25 March 2004331 Untitled, 25 March 2004 Notes 332-4 [RNA synthesis, DNA synthesis], July 1969-April 1970335-6 [DNA synthesis, B-galactosidase assay, lysozyme assay], May 1970-June 1971337 [RNA synthesis], August 1970-July 1971338-10 [Burst size, protein synthesis, nuclease activity], January 1971-January 19723311-12 [Transformation experiments, isolation of DNA], March-September 19723313-15 [Transformation experiments, extraction and isolation of DNA], September 1972-June 19733316-17 [Transformation experiments, extraction and isolation of DNA], June-October 19733318-20 [RI enzyme, staphy coli plasmid, mitochondrial DNA, xenopus DNA, miscellaneous], December 1973-November 19743321 [HIN III, spreading, transformation], December 1974-November 1975341-2 [HIN III, spreading, transformation](cont'd), December 1974-November 1975343 [DNA extraction, transformation, agarose gel], November 1975-March 1976344-5 Protocols and procedures, 1968-1981346 Gels, orig. art, 1982347-8 Product guides and procedure techniques, 1982-1997349 PRSV, PSV2 - DNA, 1983-19903410 Notebook files, 1992-19963411 Notebook files [2 CD-R], 1997-20063412-15 Protocols, 1994-19983416-17 Results - ARD, NIPPI [2 3.5 computer discs], 1995-19983418-20 Reagent and protocol manual, 1996-20033421 Microarray, 1999351-3 Gene search vector, 1999-2003354-6 HLA-B associated transcript 3 (bat3), 2000-2003357-8 Protocol II, 25 April 2003 Cheng, Tzu-Hao (Johnny) 359-11 X-rays, 2000-2003 Lab notebooks 3512 Genetics - 1, 17 August 2000-15 July 20013513 Genetics - 2, 6 July 2001-21 March 2003 Cohen, Stanley N. Lab Notebooks 3514 Misc. DH, 25 March-6 September 19633515 Chloroquine, 20 December 1963-6 March 19643516 Polymerase assays, 1963-1964351724 March-29 August 19643518 DNA preparations of GSO4 Hg, 29 June-30 August 19653519 Data II, 23 September-8 December 1965; 1986361 Data 8, 8 May-10 August 1967362-6 Taiwan Sabbatical, 1975-1994367 The Stan Cohen lab family, 1995 Gilbert, David M. Notes 368 Artwork, undated369-10 X-ray films, undated3611 Miscellaneous notes [7.5 computer disc], 1977-19853612 5S project II, 1980-19833613 Blots - TU, 19833614 5S project ex.C II, 19833615 5S project I, ex. A, 19833616 5S project, ex. D IV, 19843617 Replication sorts, 1984-19853618 X-ray films, 1984-19853619 BPV artwork, 19853620 X-ray films, 19853621-22 Miscellaneous notes, 1985-1989371 MuARS material, 1986-1987372 HTC elutriations, 1987373 Hamster elutriations, 1987-1988374 Figures, 1988375 Asilomar, 1988-1989376 Lab meeting, February 1989377 Lab meeting, 11 August 1989 Lab Notebooks 378 Cytogenetic studies of replication, 23 March-5 October 1984379 Untitled, 17 January 1988-18 September 1989 Ingmer, Hanne Lab Notebooks 3710 Genetics - 1, 28 October 1989-13 April 19903711 Genetics, 20 March-12 December 19903712 Genetics, 13 December 1990-3 August 19913713 Genetics, 6 August-12 December 19913714 Genetics, 15 December 1991-26 May 19923715 Genetics, 13 January-17 March 19923716 Genetics - 5, 24 May 1992-6 February 19933717 Genetics - 6, 11 February-20 July 1993 Notes 3718 Post printing, undated3719 Scans, undated381-4 REPA [2 3.5 computer discs], 1987-1993385 General file, 1989386 Oligos Hi, 1989-1993387-8 Gels, etc. Hi, 1991389-11 Clonings Hi, 1991-19933812-13 Gels II Hi, 1991-19933814 Notebook files, 1991-19983815 Gels III Hi, 19933816 XLA run, 2 November 19933817 XLA run, November-December 1993391-2 REPA, 1993393 XLA run - REPA, 21-23 September 1993394-5 Untitled, July-December 1993396-7 SOS, 1994398 Untitled, 1994-1995 Kendall, Kevin 399 Lab notebook file, 1985-19893910 Lab notebook, 1985-1986 Lih, Chih-Jian (Jason) Lab Notebooks 3911 gas7, 1996-20023912 DARPA tsg101, 1998-2000 Notes 3913 Sequence gene information, 1996-20003914 WI microassay, 20003915 Microassay log - exp. record, 2000-20053916 txr101, 2000-20033917 txr18 BM041, April 20013918 3, November 20013919 Antibodies - anti-TXR1-1 - peptides - (f)AB-510-4NIK, RNGG, 2001-2006401 Yeast 2 hybrid - PIAS I, 2002402 txr101 work 4, 2003403 Y2B, 2003-2004404 txr101 5, September 2003405 6, 2004406 7, January 2005407 Mouse work, 2006408 8, January 2006 Lin-Chao, Sue Lab Notebooks 409 1, 19874010 2, 19884011 3, 1988-19894012 Works of Daniel/pcr beads, 10 April 1988-15 October 19894013 TC-2 and TC-3, 1989-1990 McDowall, Kenneth Notes 4014-15 Rachel's notes, 1990-19934016 Results, 1991-1994411-2 Results (cont'd), 1991-1994413 Notebook files, 1991-1995414 Processed results, 1992-1993415 RNase E cleavage of RNAi, 1992-1993416-7 Analysis of RNE-1553 and RNE-1825 mutations, 1993-1994418-9 General file, 1994-1995 Miller, Christine Lab Notebooks 4110 Untitled, 19974111 Genetics, 19984112 PAR, 19994113 Genetics, 2000421 Genetics, 2001422 Genetics, 2002423 Genetics, 2003424 Genetics, 2004425 Genetics, 2005426 Genetics, 2006431 Genetics, 2007432 Genetics, 2008433 Genetics, 2009 Notes 434-5 77, [1967?]436 [Episomal DNA], March-October 1968437-8 [Sucrose gradients], December 1968-July 1969441 RTF, 1969442-3 [Model E run, preparative run, sucrose gradients], November 1969-March 1970444 [Model E run, sucrose gradients], April-December 1970445 RTF, 1971446-7 4, 1980448-9 Par 1, 19804410-12 Par 2, 19824413-16 Untitled, 1982-1987451-2 Par 3, undated453-6 Par 4, 1983457-9 Par 5, 19854510-13 Par 6, 19864514-15 Par 8, 19884516-17 Par 9, 1989461-4 Par 10, 1990465-7 Par 11, 1991468-11 Par 12, 19924612-15 Par 13, 19934616-17 Par 14, 1994471-4 Par 15, 1995475-8 Par 16, 1996479-11 Par 18, undated4712 PCR quantification, 2010 Qin, Zhongjun Lab Notebooks 4713 Genetics - I, 8 August 1995-9 April 1996481 Genetics - III, 27 February-20 August 1997482 Genetics - V, 23 July 1998-16 August 1999483 Genetics - VI, 20 August 1999-10 August 2000484 Genetics - 7, 12 August 2000-15 March 2001485 Genetics - 8, 19 March-18 October 2001491 Genetics - 9, 19 October 2001-8 February 2003492 Genetics - 10, 8 Feburary 2003-29 October 2004 Notes 493-4 Lab notebook file, 1995-2003495 Untitled, 1996-2005496-7 X-rays, 1995-2001498-9 [Sequencing], 1996-20034910-12 [X-rays], 1997-20034913 [Sequencing], 2001-20034914 [Reference articles], 2004 Shiffman, Dov Lab Notebooks 501 MRNA stability, 13 September 1989-22 March 1990502 Untitled, 30 November 1989-12 April 1991503 Untitled, 25 October 1990-25 March 1992504 Untitled, 8 March-18 June 1992505 Untitled, 26 March 1992-23 April 1993 Zhang, Hong Notes 506 Senescence - smurf2 - northern, 2000507 Senescence - FACS, 2000508 Senescence - microarray, 2000-2001509 Notebook files [CD-RW], 2000-20075010 Senescence - caveolin, 20015011 Senescence - h tert, 2001-20045012 Untitled, 2001-20065013 Senescence - smurf2 - western, 20025014 Senescence - smurf2 III, February-August 2003 Lab Notebooks 5015 Untitled, 13 January-12 November 19995016 Untitled, 12 March 1999-1 August 20005017 Senescence - smurf 2I, November 2000-September 20015018 Senescence - smurf 2II, September 2001-February 2002511 Senescence - smurf2 - western, 2003512 Senescence smurf2 IV, September 2003-May 2004513 Senescence - smurf2 - western, 2004514 Senescence - smurf2, June 2004-May 2005515 Senescence - smurf2, June 2005-January 2006516 Untitled lab notebook, undated517 [unknown creator] lab notebook Nick translation of pSNAC 38 and pSNAC 5, 7 January-22 April 1981518 [Jeff Dangl, MUT, etc.] lab notebook, 14 September 1983-9 March 1987519-10 [unknown creator] lab notebooks, 1987-19885111 [Gary Zweig/Dave Gilbert] T-Ag control of ori-linked gene expression and loose papers, 1988-19895112 [Gene X] lab notebook, 13 September 1989-5 January 19905113-14 Peptide [multiple contributors, Annie Chang, Dave Gilbert et al.], 1995-19995115-16 Maps-Sequences [microarray sequence data graphs; multiple contributors, Annie Chang et al.], 1996-2002 Series 6: Publication Activity, 1959-2016 By Number 521-3 Bound reprints - 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USA, 1996Born digital 253 - Electronic files, 1996597 254 - A novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells - Cell [3.5 computer disc], 1996Born digital 254 - Electronic files, 1996598 255 - Streptomyces linear plasmids that contain a phage-like, centrally located, replication origin - Mol. Microbiol., 1996Born digital 255 - Electronic files, 1996599 256 - The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer - Cell, 1996Born digital 256 - Electronic files, 19965910 257 - RNase E: still a wonderfully mysterious enzyme - Mol. Microbiol. [3 computer discs], 1996Born digital 257 - Electronic files 5911 258 - ARD-1 cDNA from human cells encodes a site-specific single strand endoribonuclease that functionally resembles Escherichia coli RNase E - J. Biol. Chem., 1997Born digital 258 - Electronic files, 19975912 260 - A developmentally regulated Streptomyces endoribonuclease resembles ribonuclease E of Esherichia coli - Mol. Microbiol., 1997Born digital 260 - Electronic files, 19975913 262 - Poly (A)- and Poly(U)-specific 3' tail shortening by E. coli ribonuclease E - Nature, 1997Born digital 262 - Electronic files, 19975914 263 - Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency - Proc. Natl. Acad. Sci. USA, 1998Born digital 263 - Electronic files, 19985915 264 - Replication at the telomeres of the Streptomyces linear plasmid pSLA2 - Mol. Microbiol. [3.5 computer disc], 19985916-17 265 - Destabilized inheritance of pSC101 and other E. coli plasmids by MpdA, a novel two component system regulator - Mol. Microbiol., 1998Born digital 265 - Electronic files, 19985918 266 - gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation - Proc. Natl. Acad. Sci. USA [2 3.5 computer discs, zip disc], 19985919 267 - Nuclear organization of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors - J. Cell Sci., 19995920 268 - Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein - Mol. Cell. Biol. [2 3.5 computer discs], 1999Born digital 269 - Electronic files, 19995921 270 - Regulation of transfer functions by the imp locus of the Streptomyces coelicolor plasmidogenic element SLP1 - J. Bacteriol. [zip disc], 19995922 271 - Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene - Gene [2 3.5 computer discs], 19995923-24 272 - Separate roles of E. coli replication proteins DnaA and DnaB in the synthesis and partitioning of pSC101 plasmid DNA - J. Bacteriol. [3.5 computer disc, zip disc], 1999Born digital 272 - Electronic files, 19995925-26 273 - TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence - Cancer Res. [3.5 computer disc, zip disc], 2000Born digital 273 - Electronic files, 2000601 274 - Unpaired terminal nucleotides and 5' monophosphorylation govern 3' polyadenylation by Escherichia coli poly (A) polymerase I - Proc. Natl. Acad. Sci. USA [3.5 computer disc, zip disc], 2000602-3 275 - Long palindromes formed in Streptomyces by non-recombination intra-strand annealing - Genes & Dev. [2 3.5 computer discs, zip disc], 2000Born digital 275 - Electronic files, 2000604 276 - Plasmid Replication and Copy Number Control - in The Horizontal Gene Pool: Bacterial Plasmids and Gene Spread (Christopher M. Thomas, ed.) [3.5 computer disc], 2000Born digital 276 - Electronic files, 2000605 277 - Mutational Analysis of the tra Locus of the Broad-Host-Range Streptomyces Plasmid pIJ101 - J. Bacteriol. [2 3.5 computer discs], 2000606 278 - Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis - J. Biol. Chem. [3.5 computer disc, zip disc], 2001607-11 279 - Neoplastic transformation and tumorigenesis associated with Sam68 protein deficiency in cultured murine fibroblasts - J. Biol. Chem. [4 3.5 computer discs, zip disc], 20006012 280 - RNA degradosomes exist in vivo in Escherichia coli as multicomponent complexes associated with the cytoplasmic membrane via the N-terminal region of ribonuclease E - Proc. Natl. Acad. Sci. USA [zip disc], 20016013 281 - A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control - Proc. Natl. Acad. Sci. USA [2 zip discs], 2001Born digital 281 - Electronic files, 20016014 282 - p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101 - Proc. Natl. Acad. Sci. USA [zip disc], 20016015-16 283 - Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription - J. Bacteriol. [3 zip discs], 2001Born digital 283 - Electronic files, 2001611 284 - Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces - Genes and Dev. [zip disc], 2001Born digital 284 - Electronic files 612 285 - Effects of 3' terminus modifications on mRNA functional decay during in vitro protein synthesis - J. Biol. Chem. [zip disc], 2001Born digital 285 - Electronic files, 2001613-7 286 - Escherichia coli poly(A) binding proteins that interact with components of degradosomes or impede RNA decay mediated by polynucleotide phosphorylase and RNase E - J. Biol. Chem. [3.5 computer disc, zip disc], 2001Born digital 286 - Electronic files, 2001618-9 287 - The RepA protein of plasmid pSC101 controls Escherichia coli cell division through the SOS response - Mol. Microbiol. [zip disc], 2001Born digital 287 - Electronic files, 20016110 288 - Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays - Genes Dev. [3.5 computer disc, zip disc], 2001Born digital 288 - Electronic files, 20016111-12 289 - Unraveling the essential role in conjugation of the Tra protein of Streptomyces lividans plasmid pIJ101 - Antonie van Leeuwenhoek [zip disc], 20016113-14 290 - Isolation and properties of Gas8, a growth-arrest-specific gene regulated during pubertal development and post-meiotic differentiation of male germ cells to produce a protein associated with the sperm motility apparatus - J. Biol. Chem. [zip disc], 2002Born digital 290 - Electronic files, 20026115 291 - RNase G complementation of rne null mutation identifies functional interrelationships with RNase E in E. coli - Mol. Microbiol. [zip disc], 2002Born digital 291 - Electronic files, 20026116 292 - Analysis of DNA microarrays using algorithms that employ rule-based expert knowledge - Proc. Natl. Acad. Sci. USA [zip disc], 2002Born digital 292 - Electronic files, 2002621 293 - Survival mechanisms for Streptomyces linear replicons after telomere damage - Mol. Microbiol., 2002Born digital 293 - Electronic files, 2002622 294 - Negative regulation of cell growth and differentiation by TSG101 through association with p21Cip1/WAF1 - Proc. Natl. Acad. Sci. USA, 2002Born digital 294 - Electronic files, 2002623-5 295 - Polyadenylation can regulate ColE1 type plasmid copy number independently of any effect on RNAI decay by decreasing the interaction of antisense RNAI with its RNAII target - Plasmid [3.5 computer disc, zip disc], 2002Born digital 295 - Electronic files, 200262 296 - Global Analysis of mRNA Decay and Abundance in E. coli at Single Gene Resolution Using Two-Color Fluorescent DNA Microarrays - Proc. Natl. Acad. Sci. USA [zip disc], 2003Born digital 296 - Electronic files, 2003627 297 - The catalytic domain of RNase E shows inherent 3' to 5' directionality in cleavage site selection - Proc. Natl. Acad. Sci. USA, 2002Born digital 297 - Electronic files, 2002628 298 - A Streptomyces coelicolor functional orthologue of Escherichia coli RNase E shows shuffling of catalytic and PNPase-binding domains - Mol. Microbiol. [zip disc], 2003Born digital 298 - Electronic files, 2003629-11 299 - Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci - Proc. Natl. Acad. Sci. USA [zip disc], 2003Born digital 299 - Electronic files, 20036212-13 300 - Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere binding protein essential for linear DNA replication - Genes Dev. [zip disc], 2003Born digital 300 - Electronic files, 2003631-6 301 - TSG101 interaction with HRS required for endosomal trafficking and receptor down-regulation - Proc. Natl. Acad. Sci. USA [CD-R], 2003Born digital 301 - Electronic files, 2003637-9 302 - Tsg101 control of human immunodeficiency virus type 1 gag trafficking and release - J. Virol. [CD-RW], 2003Born digital 302 - Electronic files, 20036310 303 - The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor - Genes Dev. [CD-RW], 2003Born digital 303 - Electronic files, 20036311-12 304 - RraA: a protein Inhibitor of RNase E activity that globally modulates RNA abundance in E. coli - Cell, 2003Born digital 304 - Electronic files, 20036313 305 - DpiA binding to the replication origin of E. coli plasmids and chromosomes destabilizes plasmid inheritance and induces the bacterial SOS response - J. Bact. [CD-RW], 2003Born digital 305 - Electronic files, 20036314 306 - Identification and characterization of a pSLA2 plasmid locus required for linear DNA replication and circular plasmid stable inheritance in Streptomyces lividans - J. Bacteriol. [CD-RW], 2003Born digital 306 - Electronic files, 20036315-17 307 - The Streptomyces coelicolor polynucleotide phosphorylase homologue, and not the putative poly(A) polymerase, can polyadenylate RNA - J. Bacteriol. [2 CD-RWs], 2003Born digital 307 - Electronic files, 20036318 308 - Genome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome - Mol Microbiol., 2004Born digital 308 - Electronic files, 20046319 309 - Global analysis of E. coli RNA degradosome function using DNA microarrays - Proc. Natl. Acad. Sci. USA [zip disc], 2004Born digital 309 - Electronic files 641 310 - Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions - Oncogene, 2004Born digital 310 - Electronic files, 2004642-3 311 - SOS Response Induction by Β-Lactams Defends Bacteria Against Antibiotic Lethality - Science, 2004Born digital 311 - Electronic files, 2004644-5 312 - Reverse transcriptase activity innate to DNA polymerase I and DNA topoisomerase I proteins of Streptomyces telomere complex - Proc. Natl. Acad. Sci. USA, 2004Born digital 312 - Electronic files, 2004646-8 313 - Smurf2 up-regulation activates telomere dependent senescence - Genes Dev., 2004Born digital 313 - Electronic files, 2004649 314 - EST-based genome-wide gene inactivation identifies ARAP3 as a host protein mediating cellular susceptibility to anthrax toxin - Proc. Natl. Acad. Sci. USA [CD-RW], 2004Born digital 314 - Electronic files, 20046410 315 - An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma - Oncogene, 2005Born digital 315 - Electronic files, 20056411 316 - Regional organization of gene expression in Streptomyces coelicolor - Gene, 2005Born digital 316 - Electronic files, 20056412 317 - Effects of threshold choice on biological conclusions reached during analysis of gene expression by DNA microarrays - Proc. Natl. Acad. Sci. USA, 2005Born digital 317 - Electronic files, 20056413 318 - Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor - Mol. Microbiol., 2005Born digital 318 - Electronic files, 20056414 319 - The LDL Receptor-Related Protein 6 (LRP6) Mediates Internalization and Lethality of Anthrax Toxin - Cell, 2006Born digital 319 - Electronic files, 20066415 320 - Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome - Mol. Microbiol. [CD-RW], 2006Born digital 320 - Electronic files, 20066416 321 - RNase E maintenance of proper FtsZ/FtsA ratio required for non-filamentous growth of Escherichia coli cells but not for colony forming ability - J. Bacteriol., 2006Born digital 321 - Electronic files, 20066417-18 322 - Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes - Genes Dev., 2006Born digital 322 - Electronic files, 20066419 323 - rag genes: novel components of the RamR regulon that trigger morphological differentiation in Streptomyces coelicolor - Mol. Microbiol., 2006Born digital 323 - Electronic files, 2006651 324 - Phenotype-based identification of host genes required for replication of African swine fever virus - J. Virol., 2006Born digital 324 - Electronic files, 2006652 325 - Retention of core catalytic functions by a conserved minimal RNase E peptide that lacks the domain required for tetramer formation - J. Biol. Chem., 2006Born digital 325 - Electronic files, 2006653-5 326 - Human MDM2 isoforms translated differentially on constitutive vs. p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops - Mol. Cell. Biol., 2006Born digital 326 - Electronic files, 2007Born digital 327 - Characterization of a large, stable, high-copy-number streptomyces plasmid that requires stability and transfer functions for heterologous polyketide overproduction, 2007656 328 - Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces - J. Bacteriol., 2007Born digital 328 - Electronic files, 2007Born digital 329 - Electronic files, 2008Born digital 330 - Glioma cells on the run � the migratory transcriptome of 10 human glioma cell lines, 2008657 331 - Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts - J. Bacteriol., 2008Born digital 331 - Electronic files, 2008Born digital 332 - Genomic expression profiling of TNF- -treated BDC2.5 diabetogenic CD4 T cells, 2008Born digital 333 - Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: functional analysis of DNase I subdomain, 2008658 334 - Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction - ACS Chem. Biol., 2008Born digital 334 - Electronic files, 2008659-10 335 - YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity - Genes Dev. [CD-R], 2008Born digital 335 - Electronic files, 20086511-12 336 - Identification of cellular genes affecting the infectivity of foot-and-mouth disease virus - J. Virol., 2009Born digital 336 - Electronic files, 2009Born digital 337 - A functional mouse retroposed gene Rps23r1 reduces Alzheimer's b-amyloid levels and tau phosphorylation, 2009Born digital 338 - Microbial drug resistance: an old problem in need of new solutions, 20096513-14 339 - Regulation of morphological differentiation in S. coelicolor by RNase III (AbsB) cleavage of mRNA encoding the AdpA transcription factor - Mol. Microbiol., 2010Born digital 339 - Electronic files, 2010Born digital 340 - Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in streptomyces coelicolor, 2010Born digital 341 - The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's b-amyloid level and tau phosphorylation, 20106515 342 - Heterodimeric integrin complexes containing Β1-integrin promote internalization and lethality of anthrax toxin - Proc. Natl. Acad. Sci. USA, 2101Born digital 342 - Electronic files, 20116516 343 - Regulation of transcription of hypoxia-inducible factor 1α (HIF-1α) by heat shock factors HSF2 and HSF4 - Oncogene, 2011Born digital 343 - Electronic files, 20116517-18 344 - Upregulation of RNase E activity by mutation of a site that uncompetitively interferes with RNA binding - RNA Biol., 2011Born digital 344 - Electronic files, 2011661-2 345 - Human genetic variation altering anthrax toxin sensitivity - Proc. Natl. Acad. Sci. USA, 2012Born digital 345 - Electronic files, 2012663 346 - Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein - Proc. Natl. Acad. Sci. USA, 2012Born digital 346 - Electronic files, 2012664 347 - Second site suppression of RNase E essentiality by mutation of the deaD RNA helicase in Escherichia coli - J. Bacteriol., 2012Born digital 347 - Electronic files, 2012Born digital 348 - Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R 665-7 349 - Spt4 is selectively required for transcription of extended trinucleotide repeats - Cell, 2012Born digital 349 - Electronic files, 2012Born digital 350 - Ribonuclease E modulation of the bacterial SOS response, 2012Born digital 351 - Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis, 2012Born digital 352 - Nutrient dependence of RNase E essentiality in Escherichia coli, 2013Born digital 353 - Upregulation of the host SLC11A1 gene by clostridium difficile toxin B facilitates glucosylation of rho GTPases and enhances toxin lethality, 2013Born digital 354 - Electronic files, 2013Born digital 355 - Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis, 2013Born digital 356 - Identification of TSG101 functional domains and p21 loci required for TSG101-mediated p21 gene regulation, 2013Born digital 357 - Modulation of anthrax toxin uptake by DKK1, an antagonist of the Wnt co-receptor LRP6, 2014Born digital 358 - Reversible vancomycin tolerance induced in Staphylococcus aureus by concurrent exposure to colistin, 2015Born digital 359 - Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntington allele by Supt4h knockdown, 2015Born digital 360 - Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting, 2015Born digital 361 - RPS23RG1 reduces AΒ oligomer induced synaptic and cognitive deficits, 2016Born digital 362 - PpsA?mediated alternative pathway to complement RNase E essentiality in Escherichia coli, 2016Born digital 363 - Inactivation of host caspases by Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus, 2016Born digital 364 - Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts associated with c9FTD/ALS, 2016 Unnumbered 668 SNC bibliography listing publications #1-78, 2 books, and 16 abstracts, 1977669 Meacock/Cohen - Analysis of pSC101 replication and incompatibility using a composite replicon, undated6610 Further studies on the mechanism of action of chloroquine: inhibition of DNA and RNA polymerase reactions, undated6611 Klug, Cohen m.s. - data, undated6612 Delayed hypersensitivity in the hamster - produced and elicited with Freund's complete adjuvant: a preliminary report, c.1959-19606613 GDH, 1963-19646614 Nucleic acids - misc., 19646615 Charts, 19666616 Selectivity of in vitro RNA synthesis on lambda DNA templates, 19676617 Genome construction between bacterial species in vitro: replication and expression of staphylococcus plasmid genes in Eschericiha coli, 19746618 The organization of sea urchin histone genes, 19756619 Basic research and the public interest - the public has the right to be assured that experiments are carried out safely, 19756620 Covalently closed circular DNA molecules of low superhelix density as intermediate forms of plasmid replication, 19766621 Genetic recombination through protoplast fusion in streptomyces, 19776622 DNA cloning and the analysis of plasmid structure and function, 19786623 Cloning and characterization of EcoRI and Hind III restriction endonuclease-generated fragments of antibiotic resistance plasmids R6-5 and R6, 19786624 Instability of plasmid DNA sequences: macro and micro evolution of the antibiotic resistance plasmid R6-5, 19786625 The transplantation and manipulation of genes in microorganisms, 19796626 An unusual transposon with long terminal inverted repeats in the sea urchin strongylocentrotus purpuratus, 19836627 The effect of charged amino acid exchange in the N-terminal domain. . ., 19896628-29 Beaucage/Miller/Cohen, 1989-19916630 Sue's paper, 19906631 Effects on the formation of antenna complex B870 of Rhodobacter capsulatus by exchange of charged amino acids in the N-terminal domain of the α and Β pigment-binding proteins, 19906632 Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300, 19996633 Streptomyces, 19996634 Foreword of "The Biotech Millennium", 2001 Unpublished 6635 Brenner/Lin-Chao/Cohen - Using retrovirus-derived portable exon to clone and study mammalian regulatory genes - Methods in Enzymology article, 19916636 Cohen and Christine Miller - Non-chromosomal antibiotic resistance in bacteria V. Recombination between an R-factor transfer unit and a chromosomal resistance determinant, undated6637 Gilbert/Ravnan/Cohen - Jackpotting does not contribute to density labelling results consistent with random replication ofm bovine papilloma virus in mouse fibroblasts, undated6638 Gilbert/TenHagen/Cohen - Integrated and extrachromosomal fomrs of a BPV/MMTV/RAS chimeric molecule have different replication patterns int ransformed mouse C127 cells, undated6639-41 Gustaffson and Meacock - Plasmid partition is not determining the incompatibility behaviour of a plasmid, 1980-19826642 Gustafsson, Meacock, Cohen - Studies on plasmid pSE101 partition and incompatibility, 1982-19836643 Interferon, 19806644 Jaurin and Cohen - A transcriptional fusion vector that utilizes the ampC-[ ]-lactamase gene of Escherichis coli for the direct selection of up-mutants in gene expression, 19876645 Jean Brevet studies - Insertion of replication regions and other endonuclease-generated DNA fragments into transposible genetic elements, 1975-1977671 Miller/Cohen - The Cmp phenotype of the par locus of pSC101. How is it related to incompatibility and replication?, 1985-1986672 Sininsky/Histone paper - Effects of upstream translation on the efficiency of translational starts on eukaryotic DNA cloned in E. coli: expression of S. Purpuratus histone H2V genomic DNA, 1980673 Taylor/Sininsky - A novel series of E. coli cloning vectors, 1981674 Troutt/Liebermann/Hoffman-Liebermann/Cohen/Kedes - Tissue-specific and regulated transcript accumulation of the pPu/pPy class of dispersed repetitive sequences, 1986-1988675 Tu/Cohen - A novel regulatory gene which enhances Tn21 transposition and suppresses cointegrate resolution, 1984-1985 Series 7: Lectures and Presentations, 1977-2016 Fear of Knowledge 676-71996-2000Born digital26 March 1995Born digital29 April 1998Born digital1 May 1998Born digital4 June 1998Born digital Handout, 22 September 1998Born digital22 June 1999678 Merigan Lecture - Stanford, 10 October 2001Born digital Merigan Lecture - Stanford, 10 October 2001Born digital Albany Lecture, 2 May 2005Born digital Chinese University, Hong Kong, November 200526 "Role of translocating genetic elements and repeated DNA sequences in the structural evolution of bacterial plasmids" at Mechanisms of Resistance to Antibiotics round table - brochure, 6-7 November 19754 The V. D. Mattia lecture - Dr. Stanley Cohen [2 audiocassettes], 1977 Kinyoun Lecture - NIH, Bethesda, Md., 3 December 1981679 Correspondence, 3 December 19814 Cohen's lecture [reel-to-reel audiotape], 3 December 19816710 Christmas lecture - University of Chicago, 5-6 December 19816711 Danish Academy of Technical Sciences - Copenhagen, 17 May 19826712 Chretien Montreal lecture - Montreal, 14 June 19826713 University of Chicago lecture, 8 December 19826714 George Washington University lecture - Washington D.C., 9 December 19826715 CETUS-UCLA Symposium Gene Expression - Park City, UT, 26 March-1 April 19836716 3-M Carlton Award ceremony - St. Paul, Minnesota, 4 May 19836717 Ferring symposium - Stockholm, Sweden, 1-2 July 19836718 Syntro - Stanford, 5-8 July 19836719 Alexander von Humboldt Foundation lecture - Stanford, 29 August-1 September 19834 Von Humboldt Conference speaker Stanley N. Cohen [audiocassette], 31 August 19836720 University of California Berkeley (UCB)-NBL International symposium, 7-10 October 19836721 Stanford Medical and Scientific Highlights (SMASH) lecture - Stanford, 2 December 19836722 Lenore Meadows Memorial Lecture - Queens College, N.Y., 24 April 19856723 3rd International Conference on Genetics and Biotechnology of Bacalli - Stanford, 15-17 July 19856724 mRNA stability as a control mechanism in gene expression - NIH lecture, 19876725 Univ. of Texas Health Science Center lecture series - Dallas, Texas, 17-18 February 19884 Cohen lecture [audiocassette], 26 April 19886726 The Russell Marker Lectures in Genetic Engineering - Penn State University, 27-29 April 19886727 NIH lecture - Bethesda, Md., 28 September 19886728 "Analysis of Mammalian Gene Regulation in situ Using Retrovirus-Based Portable Exons" - National Institutes of Health Lectureship program and certificate, 20 September 19896729 University of Pennsylvania talk, 19906730 Roy Clowes Memorial Lecture - University of Texas, Dallas, Tx., 8 November 19906731-32 University of California San Francisco (UCSF) / Exploratorium Symposium on the Recombinant DNA Revolution in Biology - Auditorium of the Palace of Fine Arts, San Francisco, 25-26 September 1992Born digital University of California San Francisco (UCSF) / Exploratorium Symposium on the Recombinant DNA Revolution in Biology - Auditorium of the Palace of Fine Arts, San Francisco, 25-26 September 19926733 University of Pennsylvania Biomedical Research Building I (BRB1) groundbreaking - Philadelphia, 5-6 October 1992Born digital University of Pennsylvania Biomedical Research Building I (BRB1) groundbreaking - Philadelphia, 5-6 October 19926734 Kornucopia: A Celebration of David Korn - text and program, 11 March 19936735 K.T. Li Symposium - Taipei, Taiwan, 1 November 19956736 Cobiotech: North-South America Conf. on Biotechnology - Cuernavaca, Mexico, 26-29 November 19956737 Melville Hare Memorial Lecture, 5 December 19956738 Charles R. Ross Seminar - University of Syracuse, 6 December 19956739 Harvard Med School lecture, 23 April 19966740 Chang Gung Medical College - Taiwan, 24 May 19966741 Smithsonian Lecture, 5 October 199696 American Society for Microbiology Division H Lecture at the 98th ASM General Meeting - plaque, 18 May 19986742 Rockefeller University lecture, 27 October 2000Born digital "The Road from the Double Helix to DNA Cloning" at Scientific Symposium: From Double Helix to Human Sequence-and Beyond - NIH, Natcher auditorium, 14 April 20034 "Deciphering Nature's Alphabet: a Conversation" - National Human Genome Research Institute [vhs videocassette], 14 April 2003Born digital Society for General Microbiology: Fred Griffith Prize Lectureship - Manchester, U.K., 8-11 September 2003Born digital Scripps lecture, October 2006Born digital Berkeley symposium talk, April 2008Born digital Pioneers in Science lecture - Stanford, 10 March 2010316 "Being a scientist: A personal history of the invention of recombinant DNA and the start of biotech" at the Academia Sinica in Taipei, Taiwan - brochure [in Newspaper and magazine clippings, press releases, brochures 2001-2013], 10 December 2010Born digital Baylor College of Medicine talk - Houston, Tx. - cancelled, 11 March 2014Born digital Guest lecture in Genetics 216, 6 May 2016 Series 8: Genetics Department, 1976-20086743 Faculty - Biochemistry 201, 1976 Clinical Pharmacology/Medicine 202 6744 Antibiotic resistance, 1979-19866745-46 Courses, 1980-19966747 Drug Interaction/adverse drug reactions, 19776748 Lecture, January 1987681-2 Notes, 1970-1979683-5 Genetics lecture on "DNA Recombination", 1977-1991686 Genetics lecture on "DNA Repair" - handouts, undated687-11 Genetics lecture on "Genes and Drugs" - lecture notes, 1978-19916812-15 Genetics lecture on "Human Gene Therapy" - Gene Therapy/Ethics, 1983-19926816-18 Genetics lecture on "Pharmacogenetics and Teratogenecity" - lecture notes, 1978-19856819-21 Genetics lecture on "Transposable Elements", 1980-19856822 Genetics seminars/colloquiums, 1989-1998 Genetics 201/202 Human Genetics 6823 Committee on Courses and Curriculum (CCC), 1981-19866824 Copyright policies, 1989-19936825 Correspondence with outside lecturers, 1982-19876826-27 Course evaluations, 1981-19876828 Final exam questions, 1979-19876829 Mid-term exam questions, 19856830 Miscellaneous correspondence, 1981-19886831 Placement exam questions, 1984-19856832 Qualifying exam, 1984-19866833 Genetics 201 syllabus - winter quarter, 1987691 Genetics 201 - class handouts, January 1989692-4 Genetics 201, 1990-1991695 Genetics 202, 1990 Genetics 208 696-7 Background material, 1998-2008698-9 Ethics, 1995-19996910March 3, 19986911 Winter 1999 - Data and data interpretation, 2002-20036912 Winter 1999 - loose papers, 1998-19996913 Evaluations, 19996914-15 Winter 2001, 2001-20036916 Lecture 1 - Overview, 10 January 20016917 Lecture 2 - Authorship and peer review, 17 January 20016918-20 Lecture 3 - Scientific error and misconduct, 24 January 20016921 Lecture 4 - Intellectual Property and Patents, 31 January 20016922 Winter 2003, 2003 Genetics 209 - Vision and Vision Disorders 6923 Evaluations, 19946924-26 Literature for eye course, 1991-19976927Spring 19906928 Vision and Vision Disorders, 19946929 Vision and Vision Disorders, 19976930 Genetics 214, 1990-19916931 Genetics 217, 19946932 Medical microbiology, 1977 Pharmacology 6933 Ethics, undated6934-35 Miscellaneous lecture notes and handouts, 1981-19906936 Steroids, undated6937 Pharmacology 209, 1981 Miscellaneous Course Outlines 701 Miscellaneous course outlines, 1981-1987702 Cell minireview - original artwork, 1995703 Molecular Matters lectures, 1995 Postgraduate Medical Education 704 Miscellaneous, 1985705 Antibiotic resistance, 1980-1983706 Basic science for clinicians, 1983-1984707-8 Recombinant DNA I, II, 1970-1983 Series 9: Contracts and Grants, 1967-2010 American Cancer Society 709 American Cancer Society, 1979-1982 MV-44N - Etiology and Evolution of Plasmids 7010 Reports, unknown date7011-30 Reports, 1971-19907031-32 MV-44Q - Etiology and Evolution of Plasmids, 1 January 1991-31 December 19927033 NP-834R - Etiology and Evolution of Plasmids [3.5 computer disc], 1 January-31 December 1993 California Breast Cancer Research Program (BCRP) - BCRP 6JB-0008 7034-35 [untitled][zip disc], 2000-2003711 [untitled], January 2000712 Annual progress report, June 2001 California Cancer Research Program (ovarian cancer) - 99-00504V-10066 713-5 California Cancer Research [zip disc], 1998-2002716 Annual reports, 2001-2001717-11 Progress reports, 1999-2002 California Cancer Research (prostate cancer) 7112 California Cancer Research, 1999-20007113 Application [zip disc], 2001-20037114 CPR ID 1II00066, 1998-20017115 Computer-based consultations in clinical therapeutics 1977-1980, 1978 Defense Advanced Research Projects Agency (DARPA) 7116-21 General, 1997-20037122-24 Defense Advanced Research Projects Agency (DARPA) [zip disc, CD-RW], 1999-2006721-6 Defense Advanced Research Projects Agency (DARPA) [zip disc, CD-RW] (cont'd), 1999-2006727-9 Defense Advanced Research Projects Agency (DARPA) I, 1997-20017210-12 Defense Advanced Research Projects Agency (DARPA) II JCR65 stats, 2000-20017213-14 Defense Advanced Research Projects Agency (DARPA) III, 2002-20047215-16 Collaboration - McAdams, Harley - Defense Advanced Research Projects Agency (DARPA) proposal, 1995-20037217 Host Oriented Therapeutics (HOT), 20027218 Genetic Regulatory Networks - MDA972-00-1-0032-A00002 - final report, 31 May 2004 Defense Advanced Research Projects Agency (DARPA) Toxins in Mammals Grant N65236-99-1-5425 7219 "Creating cellular resistance to toxins in mammals", 20007220 Milestone update, February 20017221 Annual report, 17 March 1999-16 March 20007222-40 Quarterly Reports, 1999-2004 Defense Advanced Research Projects Agency (DARPA) Viral Pathogens Grant 7241 General, 2000-20037242 References, undated731 Swine subproject, 2001732 Unconventional Concepts, Inc., 2004733 Interim progress report, 1 January-31 July 2004734-17 Quarterly Reports, 2001-2004 Department of Energy 7318 Genome to Life, 20027319 Human genome program, 19937320 DTRA attenuation / Genes and Mechanisms Underlying Microbe-Mediated Attenuation of the Host Innate Immune Response, 2009-2010 Ellison Medical Foundation / Genetic Mechanisms Regulating Aging in Differentiated Human Cell Populations 7321 General, 2002-20077322 Grant application, 20027323-25 Annual reports, 2003-20057326 FDA 223-74-3197, 1 September 1974- Funding Opportunities 7327 General, 1988-19937328 American Lung Association of San Francisco - medical research grants, 19897329 Bank of America - Giannini Foundation, 19917330Cancer biology postdoctoral application, 19857331Cancer Research Institute, 19887332 Cooperative Breast Cancer Tissue Registry (CBCTR) - request proposal, 19967333 Department of Commerce - Office of Competitive Technology Grants, 1988-19937334 Department of the Navy Research Grants for Investigation of Bioremediation of Hazardous Wastes in Marine Environments, 19907335 Government funding sources (SPO newsletter), 1990-19917336 Howard Hughes Medical Institute - grants and special programs, 19937337 Human Frontier Science Program (HFSP) - Japan - grants and fellowships, 19897338-39 Johnson and Johnson Focused Giving, 1992-19957340 Life Sciences Research Foundation (LSRF), 19827341 Lucille P. Markey Charitable Trust, 1985-19947342 March of Dimes, 19867343 Katharine McCormick Fund for Women, 1993-19947344 National Eye Institute - Institutional National Research Service Award, 19907345 NCI Outstanding Investigator's Grant, 1984-19867346 NIAID Minority Research Enhancement Program, 19887347 NIGMS MARC Honors Undergraduate Training Program, 19867348 NIGMS research reports, 1988-19947349 Pew Latin American Fellows Program, 19937350 Program in Molecular and Genetic Medicine (PMGM) research grants, 19897351 Rhone-Poulenc Rorer Pharmaceuticals sponsored research program, 19977352 University of California - Tobacco-related Disease Research Program Awards, 19917353 Wellcome Trust, 2003 Grand Challenges in Global Health / Combating Drug-Resistant HIV, TB, and Malaria by Host-Oriented Therapeutics 7354-56 General, 2003-20047357 Jetsumon Prachmsri (nee Sattabongkot), 20047358 Mentor - original proposal, 1 March 1984 Miscellaneous Applications/Grants 7359 The Breast Cancer Research Foundation, 19977360-61 Drafts, 1992-19947362 Lung cancer, 19997363 Research incentive funds, 19957364 Sponsored project routing form, 1994-19987365 NASA Microgravity Biotechnology, 1991 NIH 7366 Grants, 1987-19937367 Modular grant information, 19987368 National Institute on Aging Research - training opportunities, undated741-25 NIH AI 08619 - Genetic Mechanisms in Bacterial Antibiotic Resistance - Reports, years 1 through 26 [year 16 missing], 1967-19827426 NIH AI 10562-01 - The Replication and Transfer of R-Factors, 1 September 1971-7427 NIH AI 11697-01 - Evolution of R-Factors and Other Bacterial Plasmids, 1 September 1973-7428 NIH AI 24779 (RCDA) - Genetic Control of Non-Chromosomal Drug Resistance, 1967-19737429-30 NIH CA 87618 - Genes that Suppress Metastasis of Prostate Cancer, 1999-20027431-34 NIH EY 07106 - National Eye Institute Training Grant - Genetics - reports, 1988-1991 NIH GM 00295 - Genetics 7435 General, 19797436-42 Reports - years 1-15, 1978-1991751-4 Reports - years 1-15 (cont'd), 1978-1991755 NIH GM 08404 - Postdoctoral Training Program in Medical Genetics, 1990 NIH GM 26355 - Propagation and Inheritance of Plasmids 756-8 General, 1984-1991759-31 Reports - Years 1 through 17 [years 6 and 10 are missing], 1979-19997532-39 NIH GM 27241 - Gene Expression in Heterospecific Environments - reports, years 1 through 14 [year 7 missing], 1 July 1985-30 June 1990761-8 NIH GM 27241 - Gene Expression in Heterospecific Environments - reports, years 1 through 14 [year 7 missing] (cont'd), 1 July 1985-30 June 1990 NIH GM 42930 - New Approaches for Genomic DNA Cloning and Analysis 769-10 Background material, 1986-19897611-12 GM 42930-01, 1988-19907613 NIH GM 54158 - Polyadenylation of RNA in Bacteria, 2002 NIH HG 00325 - New Approaches for Genomic DNA Cloning and Analysis 7614 Human Genome Project, 19957615 Background material, 1988-19917616 Supplemental equipment, 1989-19917617-18 Report 2 and 3 [report 1 is missing], 1990-19937619 NIH Genome grant, 1 April 1992-31 March 1995 NIH HS 00739 - Mediphor / Computer-based On Line Drug Therapy Monitoring System 7620 Alverno Admin. Services, 19817621-22 Becton Dickinson, 1975-19767623 Cohen/Armstrong book, 1973-19767624-25 Drug interaction minutes, 1971-19777626-27 Early days, 1969-1973771 Facts and comparisons (book), 1983-1984772 GAO audit, 1974-1975773-4 Grant - 00739, 1974-1981775-6 Hospital audit I and II, 1971-1978777 Hospital Blue Cross reimbursement, 1970-1976778-11 Hospital computer system I-IV, 1970-19857712 IBM, 19847713-14 Indiana evaluation, 1976-19797715 Inquiries, 1984-19857716 Interaction review, 1983-19867717 Installation manual, 19817718-19 Mario Negri Institute, 1971-19767720-21 Medicus, 1976-1979781-4 Program documentation, undated785-6 Project documentation, 1972-1973787-8 References, 1971-1982789 Report, 1978-19957810 Reprints, 1980-19847811 Space (trailer), 1971-19857812 Technicon - El Camino, 19757813 Trademark, 1985-19877814 Walter Reed Medical Center, 19807815-20 Years 1 through 6 reports, 1971-19807821-25 NIH HS 01544 - Mycin, 1973-1980791-5 NIH HS 01544 - Mycin (cont'd), 1973-1980 NIH HS 03000 - Minerva / Computer Intervention in Clinical Drug Therapy 796 AMA system, 1983797-9 Correspondence I and II, 1977-19877910-11 Evaluation, 1977-19797912-13 Final report I and II, 1982-19877914-15 Progress report 1, 1 December 1977-30 November 19787916 Rules, 1979-1983 NIH TSG101 - Tumor Suppression Gene 7917-19 General, 1996-20017920-21 NIH grant application - pending, 1 February-1 October 19977922 NIH RR 00785 (Sumex), 1978 National Science Foundation 7923-24 GB 30581 - Replication and Transfer of R-Factors, 1971-19817925 PCM75-14176, PCM77-21058 - Replication and Transfer of R Plasmids, 1973-1980801-4 PCM75-14176, PCM77-21058 - Replication and Transfer of R Plasmids (cont'd), 1973-1980805-6 Role of mRNA Stability in Genetic Control, 1 July 1986-30 June 1991807 PAR project, 1984-1985808 Other Material - NIH Study Section posters, 1994-1999809 Unfunded Proposals - FIRCA - Gaggero/Cohen, 1996-1997 Series 10: Material Transfer Agreements, 1968-2006 Plasmids/Strains 8010 Materials sent, 2000-20018011 MTA, 1992-19978012 MTAs for Cohen lab material, 2001-20028013 MTV, 1997-19988014 PharMingen, 1992-19938015-18 Plasmid nomenclature, 1968-19768019-20 Plasmid reference center, 1976-19838021 Procedures, 19828022-24 Requested by Cohen Lab, 1978-20028025 Requests denied or unavailable to send, 20018026-30 Strains sent, 1974-1994811-12 Strains sent (cont'd), 1974-1994991 Miscellaneous plasmid data, 1969992 Miscellaneous plasmid data, 1973993 Plasmids/strains – lists, 1974-1983994 Plasmids/strains – hold for signed letter, 1983-1986 Random Homozygous Knockout (RHKO) 8113 Request/offer document, 1999-20068114-36 A-Z, 19998137 Usefulness inquiry - responses, 19928138 Research services, 1995 Series 11: Cohen/Boyer Patent: Process for producing biologically functional molecular chimeras, 1972-2003951 Cohen/Boyer original patent certificate, 1980952 Cohen/Boyer patent copies and photograph of Cohen/Boyer at ceremony [photograph], 1980953 Cohen/Boyer patent information, 1974
    Unsigned letter dated November 21, 1974 from SNC, "Associate Professor Head, Division of Clinical Pharmacology" to Bertram I. Rowland; text: addresses enclosed for Annie Chang, John Morrow and Charles Yanofsky; "I must ask that you state in your covering letter to the co-authors that rights to the invention have been (will be?) assigned to Stanford University and the University of California. As we have discussed previously, I am eager to avoid any misinterpretations by colleagues of my motives in agreeing to assist Stanford in proceeding with obtaining a patent for this invention. Your disclaimer statement makes no mention whatsoever of Stanford or UC, and gives the impression that Berg [sic] and I are proceeding (for self profit?) obtaining a patent on this process for our own use."

    Signed, undated letter from Bertram I. Rowland to SNC, at top right of page is handwritten "11/4/74" [there is no horizontal line through the number 7, so not by SNC, and November 4, 1974 is the filing date of the original patent application] and also at top right of page "File -- SN Cohen" handwritten by SNC; text of letter: "Enclosed please find Amendment" to patent application; attached seven-page AMENDMENT is dated "June 9, 1975 . . . . In response to the Office Action of March 31, 1975, please make the following amendments . . . ." signed by Bertram I. Rowland, no date on signature [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974]

    Signed memo dated October 18, 1974 from Niels Reimers to Russ Meyer, cc SNC, "Reimers file" handwritten by SNC at top right of page; text: "Professor Stanley Cohen, Clinical Pharmacology, has offered to make a donation of the share of royalty income which he would otherwise receive from licensing of the gene transplant process. Professor Cohen's desire would be to have the income allocated to a medical research fund in memory of his father. can you please advise me how Professor Cohen's most generous offer may be handled so that he can at least receive a tax benefit. . . ."

    Signed memo dated October 18, 1974 from Niels Reimers to Bill Carpenter, "SN Cohen" handwritten by SNC at top right of page; contents are catalogued in Row 374

    Unsigned letter dated September 26, 1974 from SNC to Burt Rowland [sic]; text: "I have enclosed copies of papers describing clinical use for the antibiotic inactivating enzymes synthesized by R factors. In reviewing the situation, I find that the enzyme used clinically for assaying serum kanamycin levels as well as gentamycin levels, is made by the gentamycin resistance determinant on this R factor. Unfortunately, I haven't been able to find a specific clinical paper describing use of the kanamycin monophosphotransferase enzyme clinically, or use of the streptomycin inactivating enzyme clinically (these are two genes that we've put into E. coli). However, if necessary we could very easily put in a gentamycin resistance gene to make the enzyme used in these clinical studies. I would prefer to stick with what we have if possible.. Solution used for the shearing experiment was TEN buffer . . ."; no attachments to letter in file

    Four copies of unsigned letter dated September 6, 1974 from SNC to Dick Roblin, Massachusetts General Hospital; text: "I had intended to include a copy of this memo with the letter I sent to you yesterday. It indicates the voluntary restrictions that have been observed in distribution of the pSC101 plasmid. Also, I have just been told by a reliable source that Miles Laboratories is now including a "warning" with all shipments of restriction enzymes, stating that the enzyme is sold under conditions that it will not be used for the "introduction of any viral genes" (?? T4?) or "any antibiotic resistance genes" (wow!) into bacteria. The "warning" indicates that the Miles policy is a response to the published recommendations of the NAS Committee."; no attachments to letter in file

    Three copies of unsigned letter dated September 5, 1974 from SNC to Dick Roblin, Massachusetts General Hospital; letter contents are catalogued in Rows 64 and 285

    Signed two-page letter dated November 15, 1974 from Bertram I. Rowland to SNC and Herbert W. Boyer; text: "necessary to obtain a disclaimer of invention from the co-authors. Accompanying this letter is the type of disclaimer which will be forwarded to each of the co-authors", asks for latest address for Annie C.Y. Chang, John F. Morrow, Howard M. Goodman, Robert B. Helling, Vickers Hershfield, Charles Yanofsky, Michael A. Lovett, and Donald R. Helinski, "Also, if you wish, I could forward to you my cover letter and the disclaimer, so that you might add additional remarks should you so chose [sic]. My cover letter will explain the situation to the co-authors, so that they will understand that they are not foregoing any scientific recognition, but rather that they do not fulfill the requirement of an inventor under the Patent Law. . . ."; attachment: two-page "DISCLAIMER"; text: "I, [ ], do hereby declare as follows: I am a co-author of the following publications: I have reviewed the claims of the subject application and do not believe that I am an inventor of the inventions claimed. . . ."

    Letter dated September 17, 1974 from Josephine Opalka, not signed but stamped in signature space: "ORIGINAL SIGNED BY JOSEPHINE OPALKA" to Stefano Vivona, American Cancer Society, Inc., cc Stanley Bateman, Herbert W. Boyer, Sue Clark, Niels Reimers, stamped at bottom "STANFORD UNIVERSITY SEP 18 1974 TECHNOLOGY LICENSING", in upper right corner, "xcc Cohen Latker" handwritten and "File -- Reimers" handwritten by SNC, "Re: ACS Grant No. NP-112-B (Goodman) A PROCESS FOR CONSTRUCTION OF BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS--Cohen-Boyer"; text: "Thank you for your letter of September 12, 1974 in which you reported to me the Society's decision to permit disposition of the referenced invention in accordance with the policy and practices of the Department of Health, Education and Welfare. . . ."

    Signed memo dated September 4, 1974 from Bill Carpenter to SNC, "Reimers file" handwritten by SNC near top of page; text: confirms their meeting on September 11, "As I mentioned, we are investigating the commercial potential of the gene transplant process, which will guide us in our licensing efforts. Our focus should therefore be on what developments will be necessary before the process could ever be commercially applied, and what those applications might be. Further, we will also want to carefully consider the situation in light of recent questions that have been raised as to potential hazards of future experimentation . . . . After our meeting, I plan to visit Dr. Boyer at U.C.S.F. to get his thoughts on these questions as well."

    Small, signed handwritten note dated August 28, 1974 from Niels Reimers to SNC; text: "Stan Attached are resumes of Bert Rowland and Mike Zimmerman (and Mike's former associates Dubb & Moore). . . ."; stapled behind note are four resumes: 1) Bertram I. Rowland (one page), with "Reimers file" handwritten by SNC 2) Hubert E. Dubb (four pages), 3) C. Michael Zimmerman (two pages), and 4) Gerald L. Moore (three pages)

    Signed letter dated August 22, 1974 from Stefano Vivona, American Cancer Society, Inc. to Josephine Opalka, above text is stamp "RECEIVED AUG 26 1974 BOARD OF PATENTS", near top of page is handwritten "copy -- Niels Reimers", at bottom left of page is stamp "STANFORD UNIVERSITY AUG 29 1974 TECHNOLOGY LICENSING", in top right corner of page are "xcc Cohen Kirk fS74-" and handwritten by SNC "Reimers file"; text acknowledges receipt of her August 19, 1974 letter to Dr. Mason, "Your request has been forwarded to our legal representatives for a decision. . . ."

    Unsigned letter dated August 21, 1974 from Clive S. Liston, Patent and Copyright Manager to Jesse E. Lasken, National Science Foundation, cc SNC, H.J. Latker, J. Opalka, N.J. Reimers, "Reference: Grant No. GB 30581, Subject: Invention Disclosure S74-44; text: "Enclosed is a copy of the subject invention . . . mentions support for the research from Stanford, University of California, National Institutes of Health, American Cancer Society "as well as the National Science Foundation. Since the National Institutes of Health appears to be the predominant interest agency, Stanford has elected to file a patent application pursuant to the DHEW/Stanford Institutional Patent Agreement.", Reimers "is arranging for the appropriate clearances and releases, and will contact you regarding further action."

    Unsigned letter dated August 20, 1974 from Clive S. Liston, Patent and Copyright Manager to Norman J. Latker, Department of Health, Education and Welfare, cc SNC, J.E. Lasken, J. Opalka, N.J. Reimers, "Reference: Grant No. 5 R01 AI08619, Subject: Invention Disclosure S74-44; text: "Enclosed is a copy of the subject invention . . . mentions support for the research from Stanford, University of California, National Institutes of Health, National Science Foundation, and American Cancer Society, "The National Institutes of Health is believed to be to be the predominant interest agency in this case, and Stanford has elected to file a patent application pursuant to the DHEW/Stanford Institutional Patent Agreement.", Reimers "is arranging for the appropriate clearances from the University of California and the National Science Foundation, and will contact you regarding further action."; attachment stapled behind letter is catalogued in next row

    Stapled to August 20, 1974 letter from Clive S. Liston is p. 2 of a signed letter dated August 20, 1974 from Niels J. Reimers to Norman J. Latker, Department of Health, Education and Welfare, cc SNC, J.E. Lasken, R.P. Mason, J. Opalka; text of p. 2 "By a copy of this letter, the NSF, which also has been provided the invention disclosure, is asked to release its interest to the NIH and that the NIH administer the invention on behalf of the Government, in view of the lesser support of the NSF. Because of the tremendous significance of this invention, we will plan to immediately proceed to file a patent application, particularly in view of the early publication in November 1973. It was not until this May, however, that the implications of this invention were realized by the scientific community. We intend to exercise great care in the administration of this invention, insofar as is feasible within the constraints of the patent grant which may be issued, to ensure against misuse of the invention. They key to protection against misuse, however, is not related to patent rights. It is the restraint that individuals of the international scientific community must exercise against uncontrolled experimentation. . . . "

    Page one of a signed, two-page letter dated August 20, 1974 from Niels J. Reimers to Norman J. Latker, Department of Health, Education and Welfare, cc SNC, J.E. Lasken, R.P. Mason, J. Opalka, "Reimers file" handwritten by SNC in upper right corner of page; text of p. 1 "Re; NIH Grant: AI 08619", you already have received the invention disclosure, "We hereby elect to administer the invention pursuant to the University's Institutional Patent Agreement. There are some modest complications of which you should be made aware.", details collaboration with Boyer and all other sources of funding besides NIH, have requested other funders to release their patent rights to NIH and permit NIH to administer, mentions "attached letter of August 19, 1974 from Ms. Josephine Opalka" re UC agreeing that Stanford can administer patent if UC gets a release from ACS; no attachments to letter in file

    Unsigned two-page letter dated August 20, 1974 form Niels J. Reimers to Norman J. Latker, DHEW; this document contains both pp. 1 and 2 of the letter catalogued in two previous rows

    Unsigned letter dated August 2, 1974 from Niels J. Reimers to Josephine Opalka, cc SNC, "N Reimers file" handwritten by SNC at top right of p. 1; text: thanks for July 30 letter, gives "My recommendation for handling the situation with respect to the various research sponsors . . . .In so far as the appropriate arrangement between Stanford and U.C., I propose that royalties, if any be split equally between U.C. and Stanford after deducting a percentage that we can agree upon to cover patent filing and licensing expenses of Stanford."; this appears to be the letter Opalka referred to in her letter to Reimers of July 11, 1975, the latter is catalogued in Row 384

    Signed letter dated June 26, 1974 from Niels J. Reimers to Josephine Opalka, cc SNC, "Reimers N set up file" handwritten by SNC in top right corner; text: enclosed is copy of disclosure no. S74-44, "Dr. Cohen has advised me that he does not plan to claim any royalties to which he would be otherwise entitled according to NIH and Stanford policy. Dr. Cohen understands that appropriate steps with regard to possible patent protection may be in order to ensure this work is developed for public use and benefit because, as you are aware, it is difficult to encourage development of new processes or other inventions without some form of proprietary protection to encourage a company to invest risk capital in development of new products or processes for the public. . . .", have to promptly disclose invention to NSF and HEW, "I ask that you give me an early call after you have had a chance to discuss the disclosure with Dr. Boyer."

    Stanford University Invention Disclosure, SEL Form No. 207; submitted, signed, and dated by SNC on June 24, 1974, "Title A Process for Construction of Biologically Functional Molecular Chimeras Inventor/s S.N. Cohen, H.W. Boyer", "RECORDS (a) Conception Discussion between S.N. Cohen and H.W. Boyer, Plasmid Meeting Hawaii, November 1972. Follow up discussions early 1973. Put in SNC grants January & Feb. 1973. (b) Construction/tests/useage [sic] Experiments - winter & spring of 1973. (c) Publications/notes 1) Nov. 1973 -- PNAS 70, 3240. Construction of Biologically Functional Bacterial Plasmids in vitro 2) April 1974 -- PNAS 71, 1030. Genome Construction Between Bacterial Species in vitro 3) May 1974 -- PNAS 71, 1743. Replication of Eukaryotic DNA in E. coli (d) Oral Disclosures Many seminars and oral presentations from December 1973. Also symposium presentations - to be published. ATTACHMENTS Reprints of Papers 1 & 2 & 3"

    Unsigned letter dated October 29, 1973 from SNC to Robert Helling, University of Michigan, "PATENT - COHEN BOYER" handwritten by Karen Carpenter at top of page; text: "I have enclosed negatives I used in making slides covering the material in our PNAS paper. . . . I'm sure these will be satisfactory for your needs. Things here are moving well as we try to pull data together for the Xenopus story. I'm interested in learning just how many partial digest plasmids you have run through in checking for one with an intact ribosomal DNA sequence. We've been through only 5, and haven't found even a pSC101 with any ribosomal DNA on it --- let alone an intact repeat sequence. I would appreciate your sending these negatives back to me just as soon as your photographer completes your slides."

    Undated two-page form letter from Bertram I. Rowland, cc SNC and Herbert W. Boyer, "Cohen/Boyer" handwritten at top of p. 1, SNC handwrote "File - Reimers" in upper right of p. 1; contents same as January 28, 1975 form letter catalogued in Row 152 [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974].

    Stanford University Patent Agreement, Form SU-18, signed and dated by SNC on September 1, 1972; folded with it is photocopy of "Page 1 of 2 Pages" of unsigned ASSIGNMENT form [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 312, 355, and 366]

    41-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", ". . . This application is a continuation-in-part of application Serial No. 687,430 filed May 17, 1976 which was a continuation-in-part of application Serial No. 520,691, filed November 4, 1974, now abandoned.", contains 10 claims; attached to it is unsigned two-page DECLARATION AND POWER OF ATTORNEY [signed version of form catalogued in Row 312 and older signed version of slightly different form (only 13 lawyers listed) catalogued in Row 355]; [These documents seems to be filed in the wrong folder. The contents are from 1976 or later, not 1974].

    Butterfly clamp holding nine items: 1) USPTO Office Action, from A. E. Tanenholtz to Townsend & Townsend, stamped "RECEIVED APR 5 1975 TOWNSEND AND TOWNSEND", "This application has been examined."." Part I, "Notice of References Cited, Form PTO-892." [this Notice is not in the file], Part II, "SUMMARY OF ACTION Claims 1-9 are allowed. . . . Claims 10-26 are rejected."; "PATENT - COHEN BOYER" handwritten by Karen Carpenter at top of page; [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974].

    Butterfly clamp holding nine items, continued: 2) undated "NOTIFICATION OF REJECTION(S) AND/OR OBJECTION(S) (35 USC 132)", detailing opinion on Claims 10-26, stamped "ALVIN E. TANENHOLTZ EXAMINER ART UNIT 172"; [This document seems to be filed in the wrong folder. The contents are from 1975, not 1974].

    Butterfly clamp holding nine items, continued: 3) 14-page "Brief Biography of Scientific Contributions Relating to Recombinant DNA (in historical perspective)", "Patent office File" handwritten by SNC at top of p. 1; extensive handwritten edits by SNC of the bibliographic details of the references; [This document seems to be filed in the wrong folder. It cites references as recent as 1978].

    Butterfly clamp holding nine items, continued: 4) 14-page "Brief Biography of Scientific Contributions Relating to Recombinant DNA (in historical perspective)", small handwritten edits by SNC to text on pp. 11-12; [This document seems to be filed in the wrong folder. It cites references as recent as 1978].

    Butterfly clamp holding nine items, continued: 5) photocopy of New Scientist, July 8, 1982, p. 75, containing article, "Genetic engineers stitched up over patent rights" by Paula Dwyer; "Patent file" handwritten by SNC at top right of page

    Butterfly clamp holding nine items, continued: 6) photocopy of New Scientist, November 4, 1982, p. 277, containing article, "Stanford battles for cash from DNA patent . . ." by Paula Dwyer; "Patent file" handwritten by SNC at top right of page

    Butterfly clamp holding nine items, continued: 7) photocopied pages from book, Recombinant DNA: The Untold Story by John Lear, Crown Publishers, Inc., New York, 1978; a) pp. 69-70, with "Cohen - Boyer patent file" handwritten by SNC at top of p. 69, b) pp. 83-85, c) copy of inside cover with title

    Butterfly clamp holding nine items, continued: 8) one-page "CORRECTION TO SENATE REPORT NO. 9", signed by Erin Hutchinson, who wrote "Prof. Cohen" at top right, below it "Patent" handwritten by someone else, and below them "File" handwritten by SNC; text: "In Senate Report No. 9, published in Campus Report of March 9, 1977, it was reported that Professor S. Cohen and a Berkeley colleague had filed a patent application following a disclosure arising from work in the field of recombinant DNA. That Report should have said that Stanford University had filed a patent application following a disclosure arising from work on recombinant DNA which had been carried out by Professor S. Cohen and Professor H. Boyer, University of California at San Francisco."

    Butterfly clamp holding nine items, continued: 9) undated handwritten note, "Pat, from Esther", clipped in front of six handwritten pages listing people who had requested pSC101 between 1973 and 1982 and "S.N. Cohen Lab Cultures Contrib. Directly or Indirectly to PRC" between 1976 and 1982

    954 Cohen/Boyer patent information, 1975
    Signed letter dated November 11, 1975 from Bertram I. Roland to SNC, "C/O Dr. David Hopwood, Department of Genetics, John Innes Institute", "Re: Pat. Appln. . . . Would you please execute the enclosed assignment which must be notarized by a counsel. When you return it to me, I will have Boyer execute the assignment."; two attachments: 1) "ASSIGNMENT" with SNC's name typed below signature line, but no signature, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 312, 355, and 429]; and 2) four-page "AGREEMENT CONCERNING RIGHTS IN INVENTION" dated June 19, 1975 between SNC and the Board of Trustees of the Leland Stanford Junior University, signed by SNC and Niels Reimers, at top right of first page "SU-178" and handwritten by SNC, "SNC personal files", on p. 3 refers to "the agreement between Stanford and the Board of Regents [of the University of California] dated 1975", the Department of Genetics is not mentioned in this document, which says net royalties go 1/3 SNC for distribution equally to Stanford's Research Development Fund and School of Medicine Dean's Fellowship Fund; 1/3 to the Department of Medicine; and the final 1/3 "shall be expended in the discretion of the Board of Trustees to further the objects and purposes of Stanford"

    Signed two-page letter dated November 7, 1975 from John Wicklatz, General Mills Chemicals, Inc. to Niels J. Reimers, handwritten in upper right of p. 1, "xcc Cohen f S74-43", and in SNC's handwriting, "Reimers file"; text begins, "Many thanks for the information included in your letter of October 22. . . . With regard to Professor Cohen's work on "genetic engineering" which you mentioned, we would have to say this is of no interest to us for commercial development. I asked one of our biochemists who is familiar with the work to comment on it and he described it as a "revolutionary development". However, we are not in a position at present to take on a project of this sort which involves such a variety of far-reaching, but still incompletely defined, ramifications. As to courses you might take in licensing the above technology, we have no advice to offer. Our experience in licensing has never taken us into this field."

    Small signed note dated October 6, 1975 from Jane Plagge to SNC, "Enclosed you're your records is a copy of the Agreement between the University of California and Stanford."; attached four-page "AGREEMENT CONCERNING ADMINISTRATION OF RIGHTS IN INVENTION" dated August 29, 1975 by and between University of California and Stanford, handwritten by SNC at top right is "Reimers file"; signed on p. 4 for Stanford by Niels Reimers and for the University of California by Constance W. Langton, Assistant Secretary, and David M. Blodgett, Assistant Counsel of the Regents; agreement states "the Invention shall be administered by Stanford" and that net revenues will be split in half between Stanford and UC, text elaborates: "Net revenues" as used in this Agreement shall mean the gross proceeds received by Stanford from the sale, licensing or other disposition of the Invention less (15%) of such gross proceeds to cover Stanford's indirect and overhead expenses, plus deduction of reasonable costs for preparing and filing patent applications and attorneys' fees."

    Signed memo dated December 23, 1975 from Niels Reimers to SNC, "Reimers file" handwritten by SNC at top right of page; "Enclosed are copies of the memos about the recombinant DNA process by the Technology Licensing Business School Research Assistants. John Poitras and I will schedule a meeting with you after the first of the year to discuss these reports and where we go from here."; six attachments detailed in rows below

    December 23, 1975 memo attachments: 1) Signed two-page memo dated August 13, 1975 from Ken Imatani to Niels Reimers re "File S74-43, Industrial Markets for Recombinant DNA Process; text details [p]rograms of extensive research and development for specific commercial applications", attached to memo is a table, "POTENTIAL COMMERCIAL APPLICATIONS OF RECOMBINANT DNA PROCESS"

    December 23, 1975 memo attachments, continued: 2) signed memo dated August 6, 1975 from Ken Imatani to Niels Reimers re "Discussion with Dr Boyer for Future Development Work for Recombinant DNA Process", highlighted is section that begins, "In particular, Dr Boyer hopes to produce the angiotensin-2 hormone from a chemically synthesized replicon of its DNA . . . If this procedure is successful, the next logical extension would focus on the production of insulin."

    December 23, 1975 memo attachments, continued: 3) signed memo dated August 5, 1975 from Ken Imatani to Niels Reimers re "signed memo dated August 6, 1975 from Ken Imatani to Niels Reimers re "Trip to Cutter Labs to Discuss Commercial Potential of Recombinant DNA Process"; Cutter Labs say the applications would be inappropriate for their business, however, quotes Dr. Victor Cabasso, Cutter's director of research and chairman of the Biological Section for the Pharmaceutical Manufacturers Association, "If I were a young man again, I would devote my entire life to research and development involving this process.", memo continues, "In addition, Dr Cabasso explained that an example demonstrating commercial use of the product would be required in order for a large pharmaceutical company to make a large capital investment in the process. He recommended seeking government support for a joint industry-university project"

    December 23, 1975 memo attachments, continued: 4) one-page of comments dated July 1, 1975, referred to by Josephine Opalka in her July 11, 1975 letter catalogued in Row 384 as: "comments of one reviewer of the invention. The author's identity is held in confidence"; title at top of page: "IN CONFIDENCE Re: PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL DNA CHIMERAS--Cohen-Boyer; comments conclude, "In summary, it is my view that this is a somewhat ill-conceived patent application that disregards (albeit unintentionally) the contributions of other scientists and is very basic in its concepts and applications. While one can argue that the University should attempt to benefit from this scientific achievement, I am concerned that given the fundamental nature of the work and the number of scientists involved, either directly or indirectlly, that this patent will not reflect favorably on the public service ideals of the University."; this page of comments also catalogued in Row 385

    December 23, 1975 memo attachments, continued: 5) signed memo dated October 18, 1974 from Bill Carpenter to Niels Reimers, cc Boyer and SNC; "Attached is a brief description of the technique developed by Drs. Boyer and Cohen, the development necessary for commercial application, licensing strategy, and potential dangers to humans. By copy of this memo, I am asking Dr. Boyer and Dr. Cohen to please bring to our attention anything that is incorrect or with which you may not agree."; attached two-page document, "The Plasmid Gene Transplantation Technique"; this memo and two-page attachment also catalogued in Row 410

    December 23, 1975 memo attachments, continued: 6) two-page handwritten memo dated September 18, 1974 from BC [Bill Carpenter?], "To: 74-43", "Re: Dr. Herbert Boyer", recaps Boyer's comments on potential applications, also, "The Berg committee is concerned that researchers might try putting animal virus DNA into the plasmids -- Boyer thinks this must be done someday anyway, not sure it's so dangerous -- but it should be approached carefully.", circled in red pen is sentence: "Boyer not planning on signing away his own personal rights to the invention."

    Letter dated December 9, 1975 from John K. Poitras, Associate Technology Licensing to Norman G. Brink, Merck Sharp & Dohme, cc SNC and Boyer, "Reimers file" handwritten by SNC at top right of page, note from SNC admin at bottom about trouble with Xerox; letter text: " . . . enclosing copies of the three technical papers describing the Recombinant DNA work." . . . . the Recombinant DNA work was sponsored under grants from the National Institutes of Health, the National Science Foundation, and the American Cancer Society. The latter two agencies have released their rights in the invention to the NIH so that the invention can be administered by Stanford pursuant to its Institutional Patent Agreement with the NIH. . . . We are very interested in moving rapidly to determine the applications of this widely significant technology. . . "; no attachments to letter in file

    Signed letter dated October 3, 1975 from Kenneth Imatani, Research Assistant, Office of the Vice President for Business and Finance at Stanford to Harry Robinson, Merck & Company, bcc Boyer and SNC, "Reimers file" handwritten by SNC at top right of page; text, "As agreed in our conversation of yesterday, I am sending you two articles which describe both scientific and potential commercial applications of the recombinant DNA process. Also, attached is a table which identifies particular fields of industrial microbiology in which potential commercial applications may lie. The enclosed material is being provided on a non-confidential basis, and we would very much appreciate your comments on developing a plan for bringing this process forward to public use and benefit. . . ."; attached is signed letter dated September 30, 1975 from John A. Zderic, Syntex (U.S.A.) Inc. to Kenneth Imatani, handwritten at top right "1. NJR, 2. JKP, 3. FILE 74-43 xcc Boyer Cohen" and date stamped at bottom right, "STANFORD UNIVERSITY OCT ? 1975 TECHNOLOGY LICENSING"; re commercial applications, "Unfortunately, this is an area of science where Syntex currently has no work in progress, nor do we foresee that we will be in a position to enter this highly technical field in the near term future. . . ."

    Unsigned letter dated October 3, 1975 from SNC to Bertram I. Rowland, cc Niels Reimers; text begins, "Niels has sent along the copy of your letter of October 2, and the accompanying rejection of our claims to the composition. The law may be "quite nebulous" in this area, but if it is primarily based on a "factual consideration" as you indicate, the patent examiner is totally wrong.", continues with details for 17 lines, and concludes, "Having spent so much time with you and with Stanford in attempting to provide the University with appropriate patent coverage, it is damned annoying to have the ignorance of the patent examiner on the subject present a problem of this sort."

    Signed letter dated October 3, 1975 from Niels J. Reimers to Herbert W. Boyer and SNC, cc B. I Rowland; text: per attached letter from Bert Rowland, "the claims to the method allowed, but the claims to the composition rejected. My inclination is to go along with Bert's recommendation to let the patent issue with method claims only. We can then refile for the composition claims depending on whether we have a good argument to support the composition claims. I should observe from a "marketing" point of view, the composition claims are normally more valuable than method claims; thus it may be important to develop the "good argument"., any comments appreciated; attached is signed two-page letter dated October 2, 1975 from Bertram I. Rowland to Niels J. Reimers, cc SNC, handwritten at top of p. 1: "xcc Boyer Cohen 10/3" and date stamped at bottom of p. 1: "STANFORD UNIVERSITY OCT 3 1975 TECHNOLOGY LICENSING"; text: rec'd. "Office Action in the subject application, with the claims to the method allowed, but the claims to the composition rejected. . . . This area of the law is quite nebulous and is primarily based on a factual consideration. That is, what is the likelihood of an in vitro plasmid forming a homoduplex with an in vivo plasmid. The second consideration is how would one prove that the plasmid was formed in vivo or in vitro. . . . my recommendation is to allow the claims to the method issue as a patent and refile the application and continue prosecution as to the remaining claims. . . . I look forward to hearing from you."

    October 2, 1975 letter catalogued in preceding row with "File Reimers" handwritten by SNC at top of p. 1; three attachments: 1) USPTO action cover sheet re STANLEY N. COHEN ET AL. "MAILED SEP 11 1975 GROUP 170" from A.E. Tanenholtz to Townsend and Townsend; "Responsive to communication filed 6-13-75 This action is made final."; Part I of form is unmarked, Part II lists Claims 1-12 allowed and Claims 13-26 rejected; attached is a two-page opinion dated September 16, 1981 by Alvin E. Tanenholtz, Primary Examiner with handwritten notes by SNC; 2) one-page opinion by Alvin E. Tanenholtz, examiner Art Unit 172 dated September 5, 1975, text: "Claim 23 is rejected as indefinite under 35 USC 112. Merely describing the plasmid in terms of what it can combine with is not a compete and adequate description of the plasmid. Claims 13-26 are rejected as unpatentable over each of Chakrabarty and Holloway under 35 USC 102 . . . This rejection is FINAL."; and 3) Townsend and Townsend letterhead envelope addressed to SNC, "Department of Pharmacology, Stanford University", stamped October 2, 1975

    Unsigned letter dated "27 August, 1975" from SNC to Clayton Rich, Dean, School of Medicine, Stanford University, "NR47UH" typed at top of letter and "SNC personal" handwritten by SNC at top right of page; text, "Thank you for your recent kind note concerning the molecular cloning procedure and the assignment of my share of royalties to the Dean's Fellowship Fund and for the support of biomedical research at Stanford. I appreciate your taking the time to write. I am enjoying my sabbatical leave here, and am finding that this sabbatical is accomplishing what sabbaticals are supposed to do - - - I am having the opportunity to experience a change of pace and to look at things with a different perspective."

    Signed letter dated August 6, 1975 from Clayton Rich to SNC, handwritten near top right are "SNC" and "c to SNC 8-8-75"; text: congratulates SNC "on your recent invention which undoubtly [sic] will be of great assistance in genetic research" thanks decision to name the Dean's Fellowship Fund to support postdoctoral fellows as a recipient of inventor's share and delighted Dept. of Medicine will receive half of University's share of net revenue

    Three documents photocopied half size (5.5" X 8.5") and stapled to one half of a file folder: 1) Unsigned letter dated July 30, 1975 from Niels J. Reimers to Josephine Opalka, Office of the General Counsel, University of California, cc SNC and typewritten next to his name: "Enclosed with your copy of this letter to Miss Opalka is a copy of her letter to me of July 11 for your information only." signed "Niels", below that is handwritten: "Just saw your scientific [sic] American article! We also got the $25K from BD today!, at top right of page "Reimers file" handwritten by SNC; letter text: responding to "query in your letter of July regarding the difficulty our patent counsel has had in obtaining waiver of rights", summarizes situation: seven co-authors on papers with Cohen and Boyer, only one (unnamed) has signed waiver drawn up by Bert Rowland, "At present the patent examiner has not raised the issue of possible inventorship by the co-authors. Anticipating the patent examiner Mr Rowland has asked for affidavits detailing the inventorship situation" from Professors Cohen and Boyer . . ."

    Three documents photocopied half size (5.5" X 8.5") and stapled to one half of a file folder, continued: 2) signed two-page letter dated July 11, 1975 from Josephine Opalka to Niels J. Reimers, date stamped "STANFORD UNIVERSITY JUL 14 1975 TECHNOLOGY LICENSING", "xcc Cohen" handwritten at top of p. 1 ; text: "Re: PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL DNA CHIMERAS--Cohen-Boyer I regret the delay in responding to your letter of May 2, 1975, with which you included signature copies of an Agreement covering the referenced invention. The reason for the extended delay is the departure from your original offer, expressed in your letter of August 2, 1974 . . . We interpreted your offer to mean that Stanford would assume all out-of-pocket expenses, deducting them and an appropriate overhead from future royalties prior to making distribution to U.C. Since the agreement you proffered provides for U.C.'s making out-of-pocket payments to Stanford to cover prosecution and related costs, I have had to place the invention in review procedure. This will result in our having to make some revisions in the Agreement. . . . I enclose for your information the comments of one reviewer of the invention. The author's identify is held in confidence . . . ", also has learned certain individuals at Stanford and U.C. have refused to sign waiver of rights. Insofar as this may influence our obtaining or retaining a valid patent, will you please let us have counsel's opinion as to the legal effect of these refusals."

    Three documents photocopied half size (5.5" X 8.5") and stapled to one half of a file folder, continued: 3) one-page report catalogued in Row 373

    Unsigned letter dated July 30, 1975 from Niels J Reimers to Josephine Opalka; same letter is catalogued in Row 383, only this one is full-size and has handwritten "c to SNC 8-1-75"

    Signed letter dated July 23, 1975 from Niels J. Reimers to SNC at "Department of Genetics, John Innes Institute", in upper right of page, "Reimers file" handwritten by SNC; text, received your signed copies of the Agreement and enclosed your copy, "I have advised our accounting people to defer any payments to you until after January 1, 1976 per your request."

    Full-size copy of July 11, 1975 two-page letter catalogued in Row 384, on this copy handwritten at top right of p. 1, "sent copy 7-29-75 c to SNC in Engl. 7-31-75, letter is stapled to copy of one page of comments dated July 1, 1975 catalogued in Row 373

    Signed memo dated June 20, 1975 from Cassius L. Kirk, Jr. Staff Counsel, Stanford to Niels J. Reimers, "SUBJECT: Royalty Sharing Agreement with Dr. Cohen -- Biologically Functional Molecular DNA Chimeras"; text: attached are two execution copies and an extra copy of a revision of the proposed agreement with Dr. Cohen", endeavored to incorporate substance of changes you discussed re wording of subparagraph 3(a) and "[p]er your suggestion, paragraph 7 has been deleted."; attachment catalogued in Row 390

    Attachment to June 20, 1975 memo catalogued in Row 389: signed memo dated June 19, 1975 from Cassius L. Kirk, Jr. to Niels J. Reimers, "SUBJECT: Royalty Sharing Agreement with Dr. Cohen"; text: enclosed draft of Royalty Sharing Agreement, "I have left blank the percentage of net royalty to be paid to a charitable organization designated by Dr. Cohen. I assume that Dr. Boyer will want to enter into a similar agreement and was not sure as to the percentage breakdown between Drs. Cohen and Boyer.", as noted in Kirk's April 29, 1975 memo to Reimers [catalogued in Row 395], " . . if Dr. Cohen retains the right to designate the disposition of the royalties he would otherwise have received, the IRS might consider the royalty income to be income of Dr. Cohen. . . . Should the invention turn out to be lucrative, it is conceivable that the amount of royalties contributed by Dr. Cohen would exceed 50 percent of his adjusted gross income. In such a situation, Dr. Cohen would have to pay income tax on a portion of the royalties contributed to charity. However, if Dr. Cohen and his attorney are not concerned about this possible exposure, I do not think the University need be."

    Unsigned letter dated June 18, 1975 from SNC to Bertrand I. Roland [sic], handwritten at top right (not by SNC) is "Reimers"; text: thanks for sending copy of amendment filed for patent application, "In general, I think the arguments you have made are reasonable and appropriate. However, I think you could have been a bit stronger about the "improbability" of chimeras formed by natural means between organisms that ordinarily do not exchange genetic information. Based on all that is known in molecular biology, the likelihood of such an event occurring may be even less than "infinitely small". By definition, organisms that do not exchange genetic information cannot form molecular hybrids."

    Unsigned letter dated June 9, 1975 from SNC to Niels Reimers; text, "As we discussed by telephone, I would like you to use your standard contract form in the assignment of the molecular cloning patent to Stanford by me, except as follows:" then 11 lines detailing distribution, also suggests idea for usage of funds going to Dept. of Medicine, "I plan to leave for England around June 23rd. We really need to complete arrangement prior to that time. . . ."

    Three letters stapled together: 1) unsigned letter dated June 5, 1975 from SNC to Bert Roland [sic]; text, "I plan to leave for England on my sabbatical on June 20. I hope the information I provided for you in my recent letters will be suitable, but if not we should plan to talk before I leave."; 2) unsigned two-page letter dated May 20, 1975 from SNC to Bertrand I. Roland [sic], "Reimers file" handwritten by SNC at top right of p. 1; same text as copy of letter catalogued in Row 156, except that second-to-last paragraph typed twice in this letter and second instance crossed out; 3) another unsigned two-page letter dated May 20, 1975 from SNC to Bertrand I. Roland [sic]; text begins, "I've reviewed the information sent to you by the Patent Office Examiner. I'm not sure that I understand all of the points the examiner has made in connection with his rejection of our claims 10-26 of the patent, but want to respond on the basis of what I think he is saying.", rest of letter contains response

    Signed letter dated May 12, 1976 from Bertram I. Rowland to SNC, paper has two large blue ink spots; text: re patent application, "Please find enclosed materials per your request."; no attachments to letter in file

    Signed memo dated May 2, 1975 from Niels Reimers to SNC, CC C. L. Kirk, Jr.; text: two topics, attached memo from Cash Kirk and two alternate forms of waiver re royalty income, also three execution copies plus extra copy of Assignment of Application for Patent attached; three attachments: 1) signed memo dated April 29, 1975 from Cassius L. Kirk, Jr. to Niels Reimers, "SUBJECT: Release of Rights to Receive Royalty Income (Process and Composition for Biologically Functional Molecular DNA Chimeras", date stamped, "STANFORD UNIVERSITY APR 30 1975 TECHNOLOGY LICENSING"; text: "Attached are two forms of Waiver by Dr. Cohen of his right to receive royalty income from the above referenced invention. These forms include suggestions made by Gordy Weber in a telephone conversation this morning. . . You will note that the longer form contains a statement as to the understanding by Dr. Cohen as to the disposition to be made by the University of the royalty income which would otherwise have been received by him. Gordy advises that there is some risk that by including this paragraph the IRS might consider the royalty income to be income of Dr. Cohen. . . . Please have Dr. Cohen sign the original of either of the enclosed forms (but not both)."; this memo quoted in June 19, 1975 memo catalogued in Row 390; 2) unsigned longer waiver, this waiver also catalogued in Row 405; 3) unsigned shorter waiver

    Two letters stapled together: 1) signed letter dated April 28, 1975 from Niels J. Reimers to Donald W. Carlin, Kraftco Corporation, cc H.W. Boyer and SNC, "File Reimers file" handwritten by SNC at top right of page; text: "You will recall my communication with you in November about the genetic engineering work from Stanford. Enclosed are copies of two articles from the December 1974 and April 1975 issues of Bioscience which will be useful for background regarding the genetic engineering work. Additionally, several practical applications are indicated. . . "; 2) signed letter dated April 28, 1975 from Niels J. Reimers to Bernard A. Shoor, Becton, Dickinson Electronic Laboratory, cc H.W. Boyer and SNC; text: same articles enclosed as in previous letter, mentions they contain "potential practical applications"

    signed letter dated April 15, 1975 from Niels J. Reimers to Bernard A. Shoor, Becton, Dickinson Electronic Laboratory, cc SNC, "Reimers file" handwritten by SNC at top right of page; text: "You will recall our recent telephone conversation about the "genetic engineering" discovery from Stanford. . . . ", enclosed are three PNAS reprints "which describe the work. I also refer you to recent articles in Science (14 March 1975), Chemical and Engineering News (10 March 1975), and Chemical and Engineering News 3 February 1975) [sic]. . . . I will look forward to hearing from you about Becton, Dickinson's interest in this work."; no attachments to letter in file

    Signed letter dated "18th February, 1975.", "Dictated by and signed on behalf of Dr. K. Murray." of University of Edinburgh to N.J. Reimers, "xcc Cohen Berg Massy" handwritten at top right of page, date stamped "STANFORD UNIVERSITY FEB 25 1975 TECHNOLOGY LICENSING"; text, "Thank you very much indeed for your letter of 3rd February and various enclosures clarifying the situation described by Dr. Morrow in his letter of January 23rd to me. It was very considerate of you to go to all this trouble."; paper has been dented at top by a paper clip, but no attachments in file

    Signed memo dated February 10, 1975 from Niels Reimers to William Massy, cc H.W. Boyer, SNC, "File Reimers file" handwritten by SNC at top right of page; entire text: "Last Thursday I met with Paul Berg, David Hogness, Stan Cohen, Charles Yanofsky, and Ronald Davis in Professor Berg's office. The subject was the perception of Stanford's motives by the scientific community in filing a patent application for the "gene transplant" work, while at the same time advising the scientific community to "go slow" with respect to related research. A concern also was the scientific reputation of Dr. Cohen and Dr. Boyer of the University of California, a co-inventor with Dr. Cohen. Our patent attorney had innocently touched off the above concerns by sending out a letter to a number of Dr. Cohen's and Dr. Boyer's colleagues asking them to sign affidavits that they were not co-inventors. The letter gave the mistaken impression that Drs. Cohen and Boyer were personally filing the patent application and would receive material benefit. Hurry-up phone calls, letters and telegrams were sent out but not before the situation was made known to quite a number of people. We seem to have been able to defuse the situation with respect to Drs. Cohen and Boyer. Neither are claiming any financial return from any possible revenue which might be received from the invention. There continues some concern with respect to the perception of Stanford's and U.C.'s role in this matter and several courses of action were discussed. It was considered appropriate that a meeting be scheduled with you to discuss these possible solutions which include: 1) proceeding as before 2) turning the invention over to Research Corporation and 3) abandoning the patent. I'll be in touch with you later to schedule such a meeting."

    Signed letter dated January 28, 1975 from Bertram I. Rowland to SNC, cc: Herbert W. Boyer, "Re: Pat. appln. for PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS - S. Cohen and H. Boyer"; text: "Enclosed is a copy of the letter I wrote to the co-authors of the above reference patent application clarifying the situation to them. A xerox copy of your letter dated January 22nd is also enclosed."; no attachments to letter in file

    Signed letter dated January 23, 1975 from John F. Morrow, Carnegie Institution of Washington to SNC and Boyer, cc: Bertram I. Rowland, "Reimers file" handwritten by SNC at top right of page; letter catalogued in Row 154

    Unsigned letter dated January 22, 1975 from SNC to Bertram I. Rowland; letter catalogued in Rows 153, 403, and 404

    Signed letter dated January 22, 1975 from SNC to Bertram I. Rowland, stamped "RECEIVED JAN 24 1975 TOWNSEND AND TOWNSEND PENINSULA OFFICE"; letter catalogued in Rows 153, 402, and 404

    Unsigned letter dated January 22, 1975 from SNC to Bertram I. Rowland, handwritten at bottom (not by SNC): "copies sent to: John F. Morrow, Charles Yanofsky, Herb Boyer, Donald Helinski"; letter catalogued in Rows 153, 402, and 403

    Unsigned longer version of SNC's Waiver of right to receive royalty income, "Reimers file" handwritten by SNC at top right of page; this unsigned waiver also catalogued in Row 395

    Two documents stapled together: 1) the extra copy of Assignment of Application for Patent referred to in May 2, 1975 memo catalogued in Row 395; three pages; pp. 1-2 "ASSIGNMENT OF APPLICATION FOR PATENT" with unsigned signature lines on p. 2 for Boyer, SNC, and Robert R. Augsburger, Vice President for Business and Finance, Stanford, p. 3 contains text for notarizing of all three signatures; 2) one-page unsigned Royalty Sharing Agreement described in the memo dated June 19, 1975 from Cassius L. Kirk, Jr. to Niels J. Reimers

    955 Cohen/Boyer patent information, 1976
    Signed five-page memo dated November 15, 1976 from Niels J. Reimers to SNC, Daniel Federman, I. Robert Lehman, Clayton Rich, Robert Rosenzweig, "Reimers file" handwritten by SNC in top right corner of p. 1, Subject: Genetic Engineering License; text begins, "This memo is intended as background for our meeting" November 24 at 1:30 p.m., "We anticipate receiving soon from NIH their release to license. Licensing will then be up to Stanford", sections of memo are: I. Property, II. Licensing Objectives, III. Licensing Negatives, IV. Industry Interaction, V. The Licensing Plan, and VI. Summary

    Signed memo dated November 9, 1976 from Niels Reimers to Daniel Federman, cc SNC, "Reimers file" handwritten by SNC at top right; text begins, "Enclosed are copies of the memos that we spoke about concerning Stan's participating in licensing decisions on Recombinant DNA. Also enclosed is a copy of the CETUS August 21, 1976 "Letter to the Shareholders.", SNC has reaffirmed "his association with CETUS is as a scientific consultant on a fee-for-service basis only . . . . Stan would like to participate in the meeting which is scheduled" for November 24 at 1:30 p.m.; no attachments

    Memo dated August 24, 1976 from John H. Rautischek to Betsy Clark, cc Niels Riemers [sic], Norm Latker, Chuck Herz, re "Invention disclosure NSF-75-17-GB-30581 Stanford University", in upper right "REIMERS file" handwritten by SNC; thanks for June 24th Nature article about Cohen-Boyer invention, "It is of interest that the NSF support from Herman Lewis' program was not mentioned in the article but perhaps we don't need the publicity."

    News release dated July 19, 1976 from Stanford University Medical Center News Bureau, Contacts: Spyros Andreopoulos at Stanford, Michela Reichman at UCSF, "File - PATENT" handwritten by SNC in upper right, "SCIENCE WRITERS: The following story is distributed jointly with the University of California, San Francisco"; first sentence: "Stanford University and the University of California have filed an application to patent key elements of a new genetic engineering technique developed by scientists at both institutions."

    Signed memo dated July 19, 1976 from SNC to Robert M. Rosenzweig, cc R. Augsburger, W. Massy, N. Riemers, C. Rich, SUBJECT: DNA Cloning Patent; text begins, "I wish I could agree with you that it is possible for me to completely detach myself from the University's decisions about the DNA cloning patent. . . . At the Miles Symposium where the patent issue was first raised publicly, I was able to effectively disarm critics in what could have been a very difficult situation. If instead of answering questions in an informed, honest and straightforward manner, I had responded by saying that I have "no knowledge or voice in the University's decision" as you have suggested, the public perception would surely have been that either I or the University, or both, have something to hide. . . . From my discussions with Neils Riemers [sic], it seems clear that the University administration will need to obtain advice on such matters [as patent policy] from faculty scientists, since scientific as well as purely business considerations are involved. . . . As I noted in my earlier memo to Neils Riemers [sic], I believe that any scientific advice I might provide to the Cetus Corporation can be disassociated entirely from input I provide to the University in connection with its licensing of this patent. . . ."

    Signed letter dated July 9, 1976 from Robert M. Rosenzweig to Donald S. Fredrickson, bcc Richard W. Lyman, Bill Massy, Jim Siena, Clayton Rich, Paul Berg, David Hogness, Josh Lederberg, SNC, "Reimers file" handwritten by SNC at top right; "Thank you for your letter of July 6. I was pleased to know, as indeed Dr. Perpich had told me, that you have begun a careful review of patent policies with respect to recombinant DNA. . . . we have taken some pains to consult fairly widely about the wisdom and propriety of our proposed course of action and . . . have held off making irrevocable decisions until consultative processes had a chance to work. . . .[re NIH deliberations] Let me repeat my earlier offer to participate in those deliberations, or to arrange for participation by others at Stanford. Let me also urge that you act with both deliberation and dispatch. . . ."; attached is signed letter dated July 6, 1976 from Donald S. Fredrickson to Robert M. Rosenzweig, date stamped "RECEIVED JUL 8 1976 Vice President for Public Affairs"; text: responding to your letter of June 18, " . . . Dr. Joseph Perpich has told me of his conversation with you concerning the patent issues you raised in your letter and the accompanying memorandum. . . . I have undertaken a careful review of our patent policies with respect to recombinant DNA research. . . . Norman Latker, the patent counsel" for DHEW "may already have told you--in proceeding to obtain patents, Stanford has acted consistently within the terms of the institutional agreement Stanford has with the Department. I shall keep you informed of my policy review."

    Signed memo dated July 7, 1976 from Robert M. Rosenzweig to SNC, cc R. Augsburger, W. Massy, N. Reimers, C. Rich, "Reimers file" handwritten by SNC in upper right of page; text begins "I have thought a good deal about your memorandum of June 14 to Niels Reimers. The questions you raise are not for me to decide--Clayton Rich, Bill Massy an Bob Augsburger have responsibilities more direct than mine. I cannot help but wonder, though, whether what you propose -- full knowledge of all aspects of licensing arrangement -- is the best way to achieve your aim -- avoiding damage to your professional reputation by virtue of association with unpopular University decisions. . . . If you can say to critics, "I had no knowledge of or voice in that decision" then I think you have effectively disarmed their criticism, at least as it applies to you. . . . I think you have a legitimate and important role in decision-making with respect to exploitation of the patent as a scientist and a member of the faculty. . . ."

    Signed letter dated July 2, 1976 from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY JUL 6 1976 TECHNOLOGY LICENSING", handwritten at top right 1. JKP 2. fS74-43 xcc Cohen Boyer" and in SNC's handwriting, "File - Reimers", "Applicant: STANLEY N. COHEN, et al., Serial No.: 687,430, Filing Date: 05/17/76, For: PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS, Our File No.: 5490-2-1; text begins, "The application above has been filed in the United States Patent and Trademark Office. . . ."

    Signed memo dated June 30, 1976 from Robert M. Rosenzweig to R. Augsburger, P. Berg, S. Cohen, R.W. Lyman, W.F. Massy, N. Reimers, C. Rich, J. Siena, "File Reimer" handwritten by SNC at top right, "SUBJECT: Telephone Conversation with Joseph Perpich, Associate Director for Program Planning, NIH"; text begins: "On June 29 I called Donald Fredrickson, following my letter to him of June 18. Fredrickson was not available, but Dr. Perpich returned my call. . . . He said that NIH had received "several" letters inquiring about reports of patent activity in the Recombinant DNA area by Stanford and the University of Alabama, and so there was a need for them to consider the matter and decide what, if any, position NIH should take. . . . I made three points throughout", "1. We did not want the issue to be handled in such a way as to enable people to believe that we were acting in a secretive, sly, or underhanded way. . . . 2. We had a time problem with respect to one potential licensee . . . . 3. We are eager to have NIH's views on the soundest course to pursue, understanding, of course, that we might disagree with them when we know what they are. . . . "

    Signed memo dated June 18, 1976 from Niels Reimers to Robert Rosenzweig, cc Stan Cohen, "Reimers file" handwritten by SNC at top right; text refers to attached June 14 memo from SNC re "possible appearance of a conflict of interest because of his role as a consultant with Cetus vs. his role as a confidant and advisor i the process of licensing to commercial entities . . . the association of Dr. Cohen and Dr. Lederberg with Cetus, the investment of other Stanford-related people in Cetus, as well as the investment of the University itself in Cetus, have been a matter of specific concern to representatives of a company with which we have been in contact . . . There is, of course, no issue if non-exclusive licensing only is followed. . . . I should also mention that we are not involving Herb Boyer in the business side of Recombinant DNA for even more obvious reasons. . . . would you please be kind enough to give Stan and me the benefit of your counsel?"; no attachments

    Signed two-page letter dated June 18, 1976 from Robert M. Rosenzweig to Donald S. Fredrickson, cc R.W. Lyman, W.F. Massy, C. Rich, P. Berg, S. Cohen, "Reimers file" handwritten by SNC at top right of p. 1; text begins, "From Paul Berg and others I know that you are aware of the discussions taking place at Stanford now over the wisdom of proceeding (on behalf of Stanford and the University of California) with an application for patent protection for discoveries in the area of Recombinant DNA. As you know, we began to move in this direction with the knowledge and consent of NIH and NSF . . . The purpose of this letter is to solicit your views. . . .", refers to enclosed memo "in which I have attempted to summarize some of the major questions and address them in a way that makes sense to me, at least. . . . One point on which there is substantial unanimity among the officers of the University is that, if this line of work is to be developed in a way that provides income to the holder of a patent, there is no institution or group that has a stronger claim to that income than Stanford and the University of California . . ."; attached signed four-page memo dated June 4, 1976 from Robert M. Rosenzweig to "Those Interested in Recombinant DNA", "SUBJECT: Thoughts on the Patent Question", memo sections: I The Effect of Patents on the Conduct of Science, II Commercial Development and Basic Research, III The University's Financial Condition, IV Conflict of Interest and Public Policy, then: " . . . It will be clear to readers by now that my strong preference is to press for patent protection and a responsible licensing program. . . . I solicit the views of all who read this."

    Photocopy of C&EN, June 7, 1976, p. 7, "File - Reimers" handwritten by SNC at top right, page 7 contains article, "Industry wary about genetic guidelines," no byline, text: NIH recombinant DNA guidelines "have been tailored to the conditions of research in universities and government laboratories and in some aspects may not be reasonable as guidelines for industry" according to some industry reps, "A modified version of the guidelines more useful to industry seems a good idea, both Dr. Fredrickson and industry representatives agree."

    June 4, 1976 memo described above in Row 348, with "Please circulate around lab." and "Reimers" handwritten, not by SNC, at top of p. 1; eight sets of initials at top right of p. 1, including "SNC"

    Five-page "SUPPLEMENTAL RESPONSE" to A. Tanenholtz, "Patent file" handwritten by SNC at top right of p. 1, signed on p. 5 by Bertram I. Rowland on October 4, 1977, handwritten "cc: Stanley Cohen, Herbert W. Boyer, Niels J. Reimers"; text begins, "Supplemental to the June 24 response to the Office Action of April 5, 1977, applicants, by their attorney, wish to submit the following remarks."

    Four-page "RESPONSE UNDER RULE 116" to A. Tanenholtz, "Patent file" handwritten by SNC at top right of p. 1, signed on p. 4 by Bertram I. Rowland on October 25, 1977, typewritten cc: Stanley Cohen, Niels J. Reimers"; text begins, "In response to the FINAL REJECTION of October 3, 1977, the Examiner is earnestly requested to withdraw the rejections in view of the following remarks. Unfortunately, a supplemental reponse [sic] did not arrive at the Examiner's desk prior to his preparation of the FINAL REJECTION."

    Four-page "SUPPLEMENTAL RESPONSE" to A. Tanenholtz with unsigned signature line on p. 4 for Bertram I. Rowland; text begins, "Supplemental to the June 24 response to the Office Action of April 5, 1977, applicants, by their attorney, wish to submit the following remarks. The courteous interview granted applicants' attorney is gratefully acknowledged."

    Seven-page "AMENDMENT" to A. Tanenholtz, "Patent file" handwritten by SNC at top right of p. 1, signed on p. 7 by Bertram I. Rowland on June 24, 1977; text amends Claims 40 and 44, cancels Claim 45

    Signed letter dated May 12, 1976 from Bertram I. Rowland to SNC, right margin has note handwritten by SNC, "db - please send enclosed to Bert Rowland at above address. Keep copy for our files" and written next to it in a different hand, "5-13-76", SNC notes at bottom of page, "P. 14 row" and "16 - J. Bact."; three attachments: 1) "ASSIGNMENT" signed but not dated by SNC, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 312, 366, and 429]; 2) "DECLARATION AND POWER OF ATTORNEY" signed by SNC on May 12, 1976 appointing 13 listed "attorney(s) and/or agent(s) to prosecute this application and transact all business in the Patent and Trademark Office connected therewith" (including Bertram I. Rowland) [newer signed version of slightly different form (21 lawyers listed) catalogued in Row 312 and unsigned 21-lawyer version of form catalogued in Row 430]; 3) undated 40-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS"

    Unsigned two-page letter dated April 28, 1976 from SNC to Bertram I. Roland [sic], at end of letter "c to P. Farley (CETUS) 5-5-76" handwritten, not by SNC or Karen Carpenter, 'COHEN-BOYER PATENT" handwritten at top of p. 1 by Karen Carpenter; text begins: "Enclosed is the information you requested. My lack of time right now limits completeness. I. General categories of composition. . . ." with brief scientific/technical answers numbered 1-2, 4-11

    "Dictated but not read" letter dated April 22, 1976 from Bertram I. Rowland to SNC, cc Herbert Boyer, Niels Reimers, "Reimers - file" handwritten by SNC at top right; text contains five paragraphs of requests for scientific/technical information re patent application

    Signed letter dated March 25, 1976 from John A. King, American Cyanamid Company to Niels J. Reimers, date stamped "STANFORD UNIVERSITY MAR 29 1976 TECHNOLOGY LICENSING", in top right, "xcc Cohen Poitras f S74-43" handwritten and handwritten by SNC, "file Reimers"; text: ". . . . Enclosed is a copy of King's notes on "Gene Transfer Process" from "my notes on the non-confidential conversation I had with NRDC people last Fall about the position of ICI on the gene transfer process work done at Edinburgh University. . . . "; attached Cyanamid "Memorandum II National Research Development Corp. JAK Visit of 9/3/75 Page -14- "U. Gene Transfer Process", "They told me that there had been filed, about a year ago, patent applications on the work of the two Murrays, at Edinburgh University, which had been sponsored by the Medical Research Council and which was tied up by and tied in with ICI on a gene transfer process using a phage as the carrier. . . ." text continues for total of 18 lines

    Unsigned two-page letter dated March 1, 1976 from SNC to Bert Roland [sic], cc Niels Reimers; "In reference to your plans to resubmit a patent application to provide better coverage for Stanford, I have the following comments: 1) You indicated a need to define organisms that are "ordinarily unable to exchange genetic information" I believe this can be covered by the situation where DNA from one organism is not known to be able to propagate itself in the second organism. . . . 2) In organisms that can exchange genetic information biologically without the use of this methodology, I cannot think of any way to provide tight coverage against surreptitious attempts to get around Stanford's patent. . . . I am sorry that I can't be of more help regarding item 2. However, I think you should be able to get very tight coverage in the area of item 1, which I believe is where most of the financial rewards to Stanford will eventually be realized. . . ."; letter mentions "I have enclosed a copy of my Federation Proceedings review on Translocations" but there is no attachment to letter in file

    Unsigned letter dated February 3, 1976 from SNC to Niels Reimers; re "Agreement concerning rights in DNA cloning procedure . . . It has come to my attention that a couple of other things need clarification in the above agreement: 1. The draft agreement dated June 19, 1975 has no termination date. . . . 2. I would like the agreement to contain a clause assigning all of my rights and privileges to my heirs or an assignee. . ."

    Unsigned letter dated January 28, 1976 from SNC to Niels Reimers; re "Agreement concerning processing composition for biologically functional molecular DNA chimeras, described in U.S. Patent Application 520,691", "As a follow-up to my memo of January 6, 1976 on this subject, I would like to propose the following modifications in the above agreement:" then three changes described in 17 lines of text, then, "My request for these changes is motivated by personal and tax considerations. . . ."

    Signed letter dated January 26, 1976 from Niels J. Reimers to Bertram I. Rowland, cc SNC and Boyer, "Reimers file" handwritten by SNC at top right of page; "Subject: Patent Application for "Process & Composition for Biologically Functional Molecular DNA Chimeras," your file 5490-2, Stanford file S74-43"; text: "Your recommendation regarding the prosecution o f the above patent application, as contained in your letter of January 21, 1976, and based upon discussions with Dr. Cohen, is to allow the application to issue and then refile. Please consider this letter as your authorization to refile--of course prior to the issuance of the above application."

    Signed three-page letter dated January 21, 1976 from Bertram I. Rowland to Niels J. Reimers, cc SNC, "Reimers file" handwritten by SNC at top right of page; text begins, "After being somewhat elated with my progress in the subject application, after discussions with Stanley, my gratification diminished significantly. What I apparently thought was great progress in obtaining substantial coverage for the subject invention was being undermined by new scientific advances. Accompanying this letter are the new claims which the Examiner indicated he would be willing to allow." [no attachments to letter in file], next 33 lines discuss claims, including comment re Claim 23, "Stanley informs me of two problems with this claim. . . .", final paragraph begins: "It is possible to allow the subject application to issue, while refiling a modified version and expanding the discussion concerned with the differences between DNA segments which could not be joined in vivo and those which theoretically could be joined in vivo. . . ."

    Unsigned letter dated January 6, 1976 from SNC to Niels Reimers, "File - Reimers" handwritten by SNC at top right of page; re "Licensing procedure for DNA cloning procedure"; text begins, "As we discussed today by telephone, I would like to propose some modifications in the licensing agreement that I signed and returned to you recently. These changes concern the sections on distribution of funds from the departmental and inventor's share of royalties.", comments that since "I have never received an executed copy of this agreement signed by you . . . I understand that modifications can still be readily carried out. . . ."; at bottom of page is typewritten, "Handwritten note attached: Niels, This seemed like one way to handle things without sticking you with the responsibility for re-opening the matter. Please let me know if you feel it presents any problem. Stan"

    Newspaper clipping glued to 8-1/2" X 11" paper, with "Patent File" handwritten (not by SNC) at top right of page; "By Stanford, UC Patent Filed for Genetic 'Process'", no byline, pp. 1 and ?, Medical Center MEMO, Vol. 18, No. 6, 1976.; text: ". . . If awarded, the patent would cover commercial use of the process, said Niels Reimers, manager of Stanford's technology licensing program. It would not affect its use for academic or industrial research. . . . However, William F. Massy, acting vice-president and provost, stressed that Stanford has made no decision to exploit the technique commercially. "The matter is still under discussion with federal officials and being debated internally," he said. . . ."

    956 Cohen/Boyer patent information, 1977
    Signed letter dated December 5, 1978 from Bertram I. Rowland to SNC and Boyer, cc to Reimers, "BRANSON" handwritten by SNC in margin and above in, in another hand, "Debbie Branson"; text: please sign and return enclosed "Continuation-in-Part Patent Application"; stapled behind this letter is another signed letter, dated December 6, 1979 from SNC to Rowland, text: enclosed is Continuation-in-Part Patent Application "duly signed and notarized"

    Undated 40-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", printed double-sided; attached behind it with a butterfly clamp is one sheet of paper with two forms printed on it: 1) on one side is "DECLARATION AND POWER OF ATTORNEY" signed by SNC on December 1, 1978 appointing 21 listed "attorney(s) and/or agent(s) who are partners and associates in the firm of Townsend and Townsend to prosecute this application and transact all business in the Patent and Trademark Office connected therewith" (including Bertram I. Rowland) [unsigned version of same form catalogued in Row 430 and older signed version of slightly different form (13 lawyers listed) catalogued in Row 355] ; 2) on the other side is "ASSIGNMENT" signed by SNC on December 1, 1978 and notarized by Debi Prunier, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 355, 366, and 429]

    Signed letter dated December 1, 1978 from SNC to Bertram I. Rowland, cc to Niels J. Reimers, text: "Enclosed are two signed and notarized copies of the continuation-in-part patent application for the recombinant DNA process. You will need to get Herb Boyer's signature separately."; stapled behind it is signed letter from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY NOV 9 1978 TECHNOLOGY LICENSING" with notes handwritten by SNC at top ("Rita Philip 76221") and bottom ("Debby Branson 77950"); text: "Enclosed are two copies of the captioned continuation-in-part application for review by you and the inventors. . . . . On November 7, 1978, we filed continuation application . . . of Application Serial No. 687,430 which was originally filed on May 17, 1976 . . . . The application was directed to the claims to compositions rejected by the Examiner."

    Photocopy of nine-page "DECLARATION UNDER RULE 132" signed by SNC on October 28, 1982, "Final 10/28/82" handwritten by SNC at top right of first page

    Unsigned 26-page AMENDMENT "In response to the Office Action of August 2, 1982" with signature line for Bertram I. Rowland; "To be revised" handwritten by SNC at top right of first page, on p. 10 is a post-it with illegible handwriting by SNC, on p. 17 is a post-it with "Make too b___ align of Hogness not prior" handwritten by SNC

    Signed letter dated October 17, 1978 from Niels J. Reimers to Nature Magazine, cc to SNC, Norman Latker - HEW, Dr. Donald Fredrickson - NIH, at top right "Patent file" handwritten by SNC in pen and crossed out in pencil; text: comments re "article by John Douglas, "U. S. Geneticists Look to Europe for Research Facilities," in the September 21, 1978 issue", 1) lists sources of support for the original research: American Cancer Society, National Science Foundation, National Institutes of Health, University of California, and Stanford; and 2) "The existence of a patent per se does not inhibit research in the U.S. or elsewhere. The only basis on which this particular patent (if granted) might become a factor in the choosing of a site of research is that, as noted earlier in the article, industrial licensees of the patent will be required to follow the NIH safety guidelines for genetic engineering."

    Memo dated September 27, 1978 from SNC to Niels Reimers; "I have reviewed your draft of a license agreement for companies . . . . I have no substantive modifications to suggest."; three attachments stapled to memo: 1) Signed memo dated September 19, 1978 from Robert M. Rosenzweig to Niels Reimers, cc S. Cohen, M. Hudnall, G. Lieberman, W. Massy, B. Rowland, Subject: Licenses for Cohen/Boyer work, handwritten by SNC in upper right is "Stanford Patent file"; text: he had reservations about licensing because of concern "that we not worsen the political climate in which the regulation of recombinant DNA research would be handled. My concerns in that area have greatly diminished in recent months as some balance has been restored to the public policy debate. . . . My present view, therefore, is that we should proceed to put into effect the best licensing program we can manage."; 2) Signed memo dated September 14, 1978 from Niels Reimers to SNC, Mike Hudnall, and Bert Rowland, cc to R. Rosenzweig, G. Lieberman, W. Massy, Subject: License for Cohen/Boyer Work; text: "Enclosed is your copy of a very rough first draft of a license for the Cohen/Boyer work. Each draft is numbered, and I would appreciate your not making any further distribution. Please be aware the earned royalty rate that I used is not at all firm. I particularly would like Bert's comments on basing royalties on products which may not be made by our licensee, Mike's comments on "safety guidelines," and Stan's on "End Products." . . . . After another drafting, I will probably go to one or more potential licensees on an informal basis to try it on them. . . . this scenario is of course contingent upon a formal decision by Stanford to license at all"; 3) nine-page "D R A F T AGREEMENT" for licensing Cohen/Boyer work, at top right of p. 1 is handwritten "Copy #3", on p. 3 a handwritten correction by SNC changing date of NIH Guidelines from December 1976 to July 23, 1976, and on same page after typewritten "licensee shall pay to Stanford the sum of" is a large gap in which "fifteen" handwritten by SNC, then typing resumes "thousand dollars . . ."

    Signed letter dated June 1, 1978 from Kenneth R. Allen, Townsend and Townsend to SNC and Boyer, cc to Neils[sic] Reimers, at top right handwritten (not by SNC) "opened" and date stamped "JUN 6 1978" and in left margin near bottom handwritten (not by SNC) "Returned 6/8/78"; text, enclosed for signature and return "a further declaration which must be filed in this patent application in order to place it in a condition to be issued to Stanford"; no attachments

    Signed letter dated May 2, 1978 from Bertram I. Rowland to SNC, cc to Neils [sic] Reimers, text: enclosed declaration "must be filed in this patent application in order to place it in a condition to be issued to Stanford", please sign and return; handwritten by SNC at bottom, "Please Xerox attached - Return original --> Bert Rowland"; attached is photocopy of two-page RESPONSE UNDER SECTION 152 OF THE ATOMIC ENERGY ACT OF 1954, signed by SNC on May 4, 1978, stating there was no "contract, subcontract or arrangement entered into with or for the benefit of the Nuclear Regulatory Commission" and that Stanford, UC, HEW, the ACS and NSF "all agreed that the invention was to be administered by Stanford"

    43-page report, "THE PATENTING OF RECOMBINANT DNA RESEARCH INVENTIONS DEVELOPED UNDER DHEW SUPPORT: An Analysis by the Director, National Institutes of Health November 1977"; first page is photocopy of a letter dated March 2, 1978 from Donald S. Fredrickson to Robert M. Rosenzweig, text includes, " . . . it is my recommendation that at least for the present, recombinant DNA research inventions developed under DHEW-NIH support should continue to be administered within current DHEW patent agreements with the universities."; paper clipped to front of report is small photocopied note dated March 10,1978 from Donald S. Fredrickson, not addressed to anyone,, at top right of note date stamped "MAR 29 1978" and "Patent file" handwritten by SNC, text of note begins, "Enclosed is a copy of an analysis and decision on the patenting of recombinant DNA research inventions developed with DHEW support."

    Signed letter dated March 17, 1978 from Niels J. Reimers to Bertram I. Rowland, cc to SNC and Herbert Boyer, "Patent file" handwritten by SNC at top right; Reimers states that the Atomic Energy Commission had no connection to the subject invention; SNC received support from the NIH and Stanford, Boyer was supported by the NSF, ACS and UC, concludes, "Bert, if you happen to find out what applications there are of this technology in "special nuclear material or atomic energy," I would be pleased to find out. I have not read in the literature nor heard from industry that such applications were contemplated or possible."; two attachments: 1) Signed letter dated March 14, 1978 from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY MAR 15 1978 TECHNOLOGY LICENSING" asking for information on "sources of support for the subject invention", Rowland will then prepare statements for SNC and Boyer to sign; 2) USPTO communication "FILED May 17, 1976" from Benjamin R. Padgett, Special Laws Administration Group, sent to Townsend & Townsend, date stamped in upper left corner "PAT. & T.M. OFFICE MAILED FEB 1 1978 SECURITY GROUP LICENSING & REVIEW", also stamped at top of page, "RECEIVED 1978 FEB 16 PM 3:05 TOWNSEND & TOWNSEND", text states, "The subject matter of this application appears to be "useful in the production or utilization of special nuclear material or atomic energy" as recited in Section 152 of the Atomic Energy Act of 1954" and asks if any support from the Atomic Energy Commission, concludes, "This application will be reached for processing in about FORTY-FIVE DAYS. Final disposition thereof will be expedited if an appropriate statement is filed during this period."

    Photocopy of article, "U.S. Approval: Stanford and UC Can License 'Gene-Splicing' by Charles Petit, San Francisco Chronicle, March 14, 1978, no page number provided, "Patent file" handwritten by SNC at top right of page

    957 Cohen/Boyer patent information, 1978
    Signed letter dated December 5, 1978 from Bertram I. Rowland to SNC and Boyer, cc to Reimers, "BRANSON" handwritten by SNC in margin and above in, in another hand, "Debbie Branson"; text: please sign and return enclosed "Continuation-in-Part Patent Application"; stapled behind this letter is another signed letter, dated December 6, 1979 from SNC to Rowland, text: enclosed is Continuation-in-Part Patent Application "duly signed and notarized"

    Undated 40-page "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", printed double-sided; attached behind it with a butterfly clamp is one sheet of paper with two forms printed on it: 1) on one side is "DECLARATION AND POWER OF ATTORNEY" signed by SNC on December 1, 1978 appointing 21 listed "attorney(s) and/or agent(s) who are partners and associates in the firm of Townsend and Townsend to prosecute this application and transact all business in the Patent and Trademark Office connected therewith" (including Bertram I. Rowland) [unsigned version of same form catalogued in Row 430 and older signed version of slightly different form (13 lawyers listed) catalogued in Row 355] ; 2) on the other side is "ASSIGNMENT" signed by SNC on December 1, 1978 and notarized by Debi Prunier, listing both SNC and Boyer as Assignors, Title of Invention: Process and Composition for Biologically Functional Molecular Chimeras, and the Board of Trustees of the Leland Stanford Junior University as Assignee, form states that for $1.00 Assignors have "sold, assigned and transferred . . . . all right, title and interest in and to the said invention . . . " to Assignee [signed and unsigned versions of this ASSIGNMENT form also catalogued in Rows 355, 366, and 429]

    Signed letter dated December 1, 1978 from SNC to Bertram I. Rowland, cc to Niels J. Reimers, text: "Enclosed are two signed and notarized copies of the continuation-in-part patent application for the recombinant DNA process. You will need to get Herb Boyer's signature separately."; stapled behind it is signed letter from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY NOV 9 1978 TECHNOLOGY LICENSING" with notes handwritten by SNC at top ("Rita Philip 76221") and bottom ("Debby Branson 77950"); text: "Enclosed are two copies of the captioned continuation-in-part application for review by you and the inventors. . . . . On November 7, 1978, we filed continuation application . . . of Application Serial No. 687,430 which was originally filed on May 17, 1976 . . . . The application was directed to the claims to compositions rejected by the Examiner."

    Photocopy of nine-page "DECLARATION UNDER RULE 132" signed by SNC on October 28, 1982, "Final 10/28/82" handwritten by SNC at top right of first page

    Unsigned 26-page AMENDMENT "In response to the Office Action of August 2, 1982" with signature line for Bertram I. Rowland; "To be revised" handwritten by SNC at top right of first page, on p. 10 is a post-it with illegible handwriting by SNC, on p. 17 is a post-it with "Make too b___ align of Hogness not prior" handwritten by SNC

    Signed letter dated October 17, 1978 from Niels J. Reimers to Nature Magazine, cc to SNC, Norman Latker - HEW, Dr. Donald Fredrickson - NIH, at top right "Patent file" handwritten by SNC in pen and crossed out in pencil; text: comments re "article by John Douglas, "U. S. Geneticists Look to Europe for Research Facilities," in the September 21, 1978 issue", 1) lists sources of support for the original research: American Cancer Society, National Science Foundation, National Institutes of Health, University of California, and Stanford; and 2) "The existence of a patent per se does not inhibit research in the U.S. or elsewhere. The only basis on which this particular patent (if granted) might become a factor in the choosing of a site of research is that, as noted earlier in the article, industrial licensees of the patent will be required to follow the NIH safety guidelines for genetic engineering."

    Memo dated September 27, 1978 from SNC to Niels Reimers; "I have reviewed your draft of a license agreement for companies . . . . I have no substantive modifications to suggest."; three attachments stapled to memo: 1) Signed memo dated September 19, 1978 from Robert M. Rosenzweig to Niels Reimers, cc S. Cohen, M. Hudnall, G. Lieberman, W. Massy, B. Rowland, Subject: Licenses for Cohen/Boyer work, handwritten by SNC in upper right is "Stanford Patent file"; text: he had reservations about licensing because of concern "that we not worsen the political climate in which the regulation of recombinant DNA research would be handled. My concerns in that area have greatly diminished in recent months as some balance has been restored to the public policy debate. . . . My present view, therefore, is that we should proceed to put into effect the best licensing program we can manage."; 2) Signed memo dated September 14, 1978 from Niels Reimers to SNC, Mike Hudnall, and Bert Rowland, cc to R. Rosenzweig, G. Lieberman, W. Massy, Subject: License for Cohen/Boyer Work; text: "Enclosed is your copy of a very rough first draft of a license for the Cohen/Boyer work. Each draft is numbered, and I would appreciate your not making any further distribution. Please be aware the earned royalty rate that I used is not at all firm. I particularly would like Bert's comments on basing royalties on products which may not be made by our licensee, Mike's comments on "safety guidelines," and Stan's on "End Products." . . . . After another drafting, I will probably go to one or more potential licensees on an informal basis to try it on them. . . . this scenario is of course contingent upon a formal decision by Stanford to license at all"; 3) nine-page "D R A F T AGREEMENT" for licensing Cohen/Boyer work, at top right of p. 1 is handwritten "Copy #3", on p. 3 a handwritten correction by SNC changing date of NIH Guidelines from December 1976 to July 23, 1976, and on same page after typewritten "licensee shall pay to Stanford the sum of" is a large gap in which "fifteen" handwritten by SNC, then typing resumes "thousand dollars . . ."

    Signed letter dated June 1, 1978 from Kenneth R. Allen, Townsend and Townsend to SNC and Boyer, cc to Neils[sic] Reimers, at top right handwritten (not by SNC) "opened" and date stamped "JUN 6 1978" and in left margin near bottom handwritten (not by SNC) "Returned 6/8/78"; text, enclosed for signature and return "a further declaration which must be filed in this patent application in order to place it in a condition to be issued to Stanford"; no attachments

    Signed letter dated May 2, 1978 from Bertram I. Rowland to SNC, cc to Neils [sic] Reimers, text: enclosed declaration "must be filed in this patent application in order to place it in a condition to be issued to Stanford", please sign and return; handwritten by SNC at bottom, "Please Xerox attached - Return original --> Bert Rowland"; attached is photocopy of two-page RESPONSE UNDER SECTION 152 OF THE ATOMIC ENERGY ACT OF 1954, signed by SNC on May 4, 1978, stating there was no "contract, subcontract or arrangement entered into with or for the benefit of the Nuclear Regulatory Commission" and that Stanford, UC, HEW, the ACS and NSF "all agreed that the invention was to be administered by Stanford"

    43-page report, "THE PATENTING OF RECOMBINANT DNA RESEARCH INVENTIONS DEVELOPED UNDER DHEW SUPPORT: An Analysis by the Director, National Institutes of Health November 1977"; first page is photocopy of a letter dated March 2, 1978 from Donald S. Fredrickson to Robert M. Rosenzweig, text includes, " . . . it is my recommendation that at least for the present, recombinant DNA research inventions developed under DHEW-NIH support should continue to be administered within current DHEW patent agreements with the universities."; paper clipped to front of report is small photocopied note dated March 10,1978 from Donald S. Fredrickson, not addressed to anyone,, at top right of note date stamped "MAR 29 1978" and "Patent file" handwritten by SNC, text of note begins, "Enclosed is a copy of an analysis and decision on the patenting of recombinant DNA research inventions developed with DHEW support."

    Signed letter dated March 17, 1978 from Niels J. Reimers to Bertram I. Rowland, cc to SNC and Herbert Boyer, "Patent file" handwritten by SNC at top right; Reimers states that the Atomic Energy Commission had no connection to the subject invention; SNC received support from the NIH and Stanford, Boyer was supported by the NSF, ACS and UC, concludes, "Bert, if you happen to find out what applications there are of this technology in "special nuclear material or atomic energy," I would be pleased to find out. I have not read in the literature nor heard from industry that such applications were contemplated or possible."; two attachments: 1) Signed letter dated March 14, 1978 from Bertram I. Rowland to Niels J. Reimers, date stamped "STANFORD UNIVERSITY MAR 15 1978 TECHNOLOGY LICENSING" asking for information on "sources of support for the subject invention", Rowland will then prepare statements for SNC and Boyer to sign; 2) USPTO communication "FILED May 17, 1976" from Benjamin R. Padgett, Special Laws Administration Group, sent to Townsend & Townsend, date stamped in upper left corner "PAT. & T.M. OFFICE MAILED FEB 1 1978 SECURITY GROUP LICENSING & REVIEW", also stamped at top of page, "RECEIVED 1978 FEB 16 PM 3:05 TOWNSEND & TOWNSEND", text states, "The subject matter of this application appears to be "useful in the production or utilization of special nuclear material or atomic energy" as recited in Section 152 of the Atomic Energy Act of 1954" and asks if any support from the Atomic Energy Commission, concludes, "This application will be reached for processing in about FORTY-FIVE DAYS. Final disposition thereof will be expedited if an appropriate statement is filed during this period."

    Photocopy of article, "U.S. Approval: Stanford and UC Can License 'Gene-Splicing' by Charles Petit, San Francisco Chronicle, March 14, 1978, no page number provided, "Patent file" handwritten by SNC at top right of page.

    958 Cohen/Boyer patent information, 1978
    Binder clip holding three sets of documents, each group held together with a butterfly clamp. First butterfly clamp holds four items: 1) Photocopy of nine-page "DECLARATION UNDER RULE 132" signed by SNC on October 28, 1982

    2) article by S.N. Cohen and A.C.Y. Chang, J. Bac., 1977

    3) article by S. Chang and S.N. Cohen, PNAS, 1977

    4) first page of article by S.N. Cohen et al., PNAS, 1973

    Binder clip holding three sets of documents, each group held together with a butterfly clamp. Second butterfly clamp holds nine items: 1) last four pages of article by S. Chang and S.N. Cohen, PNAS, 1977

    2) unsigned letter dated September 5, 1974 from SNC to Dick Roblin, Mass. General listing 32 people who have requested and received the pSC101 plasmid

    3) unsigned two-page letter dated September 6, 1977 from SNC to Donald Fredrickson, Director, NIH enclosing a manuscript [not included in this file] in press with PNAS, "I have taken the unusual step of sending it to you prior to publication because I believe the findings have policy, as well as scientific, importance with regard to the regulation of recombinant DNA", " . . . along with virtually all of the other scientists who first raised these questions, I have since come to believe that our initial concerns were greatly overstated."

    4) photocopy of two-page "DECLARATION UNDER RULE 132" signed by Herbert W. Boyer on October 21, 1982

    5) photocopy of Gordon Research Conferences "Frontiers of Science" Application to attend "Conference on extrachromosomal Elements" July 6-10, 1981 at Tilton School, signed by Christine Miller on April 2, 1981

    6) photocopy of three-page "DECLARATION UNDER RULE 132" signed by Stanley Falkow on October 22, 1982

    7) article by Guerry, Van Embden and Falkow, J. Bac., 1974

    8) three-page "DECLARATION UNDER RULE 132" signed October 1, 1982 by Bernard Weisblum

    9) first three pages of article by Tanaka and Weisblum, J. Bac., pp. 354-362, 1975 (the rest of the article is in butterfly clamp catalogued in next row)

    Binder clip holding three sets of documents, each group held together with a butterfly clamp. Third butterfly clamp holds 18 items: 1) last six pages of article by Tanaka and Weisblum, J. Bac., pp. 354-362, 1975 (first three pages is in butterfly clamp catalogued in previous row)

    2) photocopy of two-page "DECLARATION UNDER RULE 132" signed by David S. Hogness on October 27, 1982

    3) photocopy of three-page "DECLARATION UNDER RULE 132" signed by Donald R. Helinski on October 27, 1982

    4) article by Hershfield, Boyer, Yanofsky, Lovett, and Helinski, PNAS, 1974

    5) photocopy of four-page "DECLARATION UNDER RULE 132" signed by Bertram I. Rowland on October 29, 1982

    6) unsigned letter dated October 25, 1979 from Bertram I. Rowland to Robert B. Helling, cc to Niels Reimers, "11/5" handwritten at bottom right of first page

    7) almost illegible photocopy of "____ Withholding Exemption Certificate" and "Patent Agreement" stamped "RECEIVED GRADUATE DIVISION SAN FRANCISCO JUL 13 1972" signed by Robert B. Helling and Administrative Assistant H. Kay Stewart on July 6, 1972

    8) U.C. Employment Form signed by Robert B. Helling on July 6, 1972, "Dr. Robert Helling is an Associate Professor from the University of Michigan, Ann Arbor, here on a year's sabbatical doing special research with Dr. H.W. Boyer. He is a Special Fellow with the NIH."

    9) Page 1 of Dept. of Health, Education, and Welfare Public Health Service Facilities and Commitment Statement for Research Fellowship, comments of Sponsor, " . . . During his sabbatical leave I expect Dr. Helling to participate in one area of our research program designed to elucidate the mechanism of DNA-protein interaction. . . ."

    10) another photocopy of form catalogued above in 8)

    11) Dept. of Health, Education, and Welfare Public Health Service Research Fellowship Activation Notice re Fellow Robert B. Helling, award period "From 6/11/72 Through 8/10/73 (14 Months)", signed by Helling on June 12, 1972 and by Herbert W. Boyer on June 14, 1972

    12) Dept. of Health, Education, and Welfare Public Health Service Notice of Research Fellowship Award to Robert B. Helling, sponsor Herbert W. Boyer, date issued May 26, 1972

    13) another photocopy of form catalogued above in 11)

    14) U.C. Change in Employment Status signed by H. Kay Stewart for Robert B. Helling "From 7/1/83 Through 8/31/73" without salary, "He is staying an additional two months to complete his research project."

    15) Dept. of Health, Education, and Welfare Public Health Service Notice of Research Fellowship Award to Helling, date issued July 25, 1972

    16) almost illegible photocopy of Robert B. Helling's Report of Gift Acceptance, date gift received July 31, 1972, "Your application for a Public Health Service Research Fellowship has been approved"

    17) Dept. of Health, Education, and Welfare Public Health Service Research Fellowship Termination Notice regarding Robert B. Helling, scheduled termination date, August 10, 1973, summary of research undertaken lists Cohen, Chang, Boyer, and Helling, PNAS in press

    18) SNC article, "The Stanford DNA Cloning Patent", 1982

    959 Cohen/Boyer patent information, 1979
    Unsigned copy of a four-page letter dated October 25, 1979 from Bertram I. Rowland to Robert B. Helling, cc to Niels Reimers; four markings near top of p.1 1) date stamped "STANFORD UNIVERSITY OCT 26 1979 TECHNOLOGY LICENSING", 2) handwritten "xcc Cohen Ditzel 1. JKP 2. S74-43", 3) a second date stamp at top of p. 1, "OCT 30 1979", and 4) "patent file" handwritten by SNC; letter begins, "Thank you very much for the courtesy of your conversation. Enclosed with this letter is a copy of the claims which are presently before the Patent Office, the claims having been rejected primarily because of the prior publications by the inventors in conjunction with others. As I explained to you, it has been Patent Office policy to treat a publication which includes an inventor as a reference as prima faciae [sic] evidence of co-inventorship. The burden then shifts to the applicant to establish that the co-authors are also not co-inventors. However, if a co-author will not cooperate, then the applicants must seek judicial help in requiring the co-author to prove that he is also a co-inventor. I think you will agree with me that this Patent Office policy has no real basis in fact, since considerations of inventorship based on patent principles are rarely involved in the considerations of co-authors. The concept of an inventor is a legal concept which is based on certain factual inquiries." Rowland outlines his understanding of the facts for approx. two pages, then "If after reading this letter, you still believe that you should be accorded inventorship, I would greatly appreciate it if you would write down the contributions you feel you made toward the ultimate success of the development as presently claimed. . . . In the alternative, after reconsideration if you believe you are not a co-inventor, I would greatly appreciate your signing a Disclaimer of Co-Inventorship as to the accompanying claims. Purely from my own personal viewpoint, if you truly believed yourself an inventor, you had the opportunity to file a patent application in your name in conjunction with the others whom you deemed were co-inventors. . . . At the present time, unless the Patent Office withdraws its rejection, the application will have to go to appeal. I believe the only course of action left to the applicants is to file a cause of action in the District of Columbia requesting the Court to order the Commissioner to issue the patent and deposing you, so that we can once and for all determine all the facts and obtain a judicially sanctioned inventive entity."; at end of letter, "Enclosures 1. Claims 1-17 2. Disclaimer", but no attachments to this copy of letter; another copy of this letter catalogued above

    Signed letter dated October 2, 1979 from Bertram I. Rowland to Niels J. Reimers, cc to SNC and Boyer, stamped "OCT 3 1979" at top of page and "Patent file" handwritten by SNC at top right; text re proposed letter to Helling enclosed for comments or suggestions, when Rowland spoke to Helling, "by the end of the conversation, he seemed to be willing at least to rethink his position albeit reluctantly. I therefore have indited the enclosed epistle in the hopes that the gospel according to St. Bertram may have some positive effect."; two attachments: 1) unsigned, undated four-page draft of letter from Rowland to Helling, and 2) five pages of undated text which begins, "WHAT IS CLAIMED IS:" and describes 17 claims

    Photocopy of three-page "DECLARATION UNDER RULE 131" signed by SNC on February 7, 1980, but not signed by Boyer, stamped "COPY" at top left, and "patent file" handwritten by SNC in upper right, post-it on front page with handwritten note, "from: Bert Rowland To: Dr. Cohen", on p. 2, line 19 the word "kanamycin" has been crossed out in pencil and "TC" handwritten above it; attached are five photocopied, undated lab notebook pages with handwritten notes by Annie Chang (same pages as in document catalogued in Rows 272 and 273)

    Photocopy of nine-page "THIRD PRELIMINARY AMENDMENT" signed by Bertram I. Rowland on May 9, 1979, handwritten at top of p.1 "xcc Stan Cohen Roger Ditzel 1. JKP 2. f S74-43" and in SNC's handwriting "Patent file"

    Two-page signed letter dated April 9, 1979 from Paul D. Flehr of Flehr, Hohback, Test, Albritton & Herbert to Niels J. Reimers, three markings near top of p.1 1) date stamped "STANFORD UNIVERSITY APR 10 1979 TECHNOLOGY LICENSING", 2) handwritten "xcc Herzenberg Rowland Hudnall Cohen S74-43 S77-17", 3) "Patent file" handwritten by SNC; "Since our letter of March 23, we have received letters from our Japanese and German associates with respect to patents in foreign countries covering microorganisms and their processes. . . . the Japanese Patent Office has recently prepared examination standards on this matter. . . . According to my interpretation, the Japanese standards will permit the patenting of new microorganisms and processes for producing them. . . . In all probability these standards will be used in other foreign countries, and therefore it is suggested that you keep them in mind in preparing and filing new applications.", quotes their German associate:, "in Germany (and as far as I am informed also in other Euorpean [sic] countries as well) new microorganisms and microbiological processes may be patentable . . . ."; attachment: unsigned letter dated "March, 1979" from Nakamura, Yamamoto, Takeda and Partners to "Gentelemen" [sic], "Enclosed is an English translation of the revised part of the Examination Standard. Although the revision is still referred to as a proposal, it is almost certain to be formally adopted in the near future and applied to all applications."; attached to the attachment is a six-page English-language "Examination Standard Relating to Inventions of Microorganism Per Se" from "Office of Examination Standards"

    Four-page signed letter dated February 8, 1979 from Paul D. Flehr of Flehr, Hohback, Test, Albritton & Herbert to Niels J. Reimers, cc to Bertram I. Rowland, three markings near top of p.1 1) date stamped "STANFORD UNIVERSITY FEB 9 1979 TECHNOLOGY LICENSING", 2) handwritten "xcc Cohen 1. JKP 2. S74-43", 3) "File" handwritten by SNC; nine paragraphs summarizing February 2 conversation with Bert Rowland re "the various Cohen et al. applications" and seven paragraphs summarizing subsequent conversation with "Tom Kiley of Lyon & Lyon about his experiences in this field."

    9510 Cohen/Boyer patent information, 1980
    Signed memo dated December 19, 1980 from SNC to Donald Kennedy, SUBJECT: Recombinant DNA Patent; re licensing the patent: ". . . . The purpose of this memo is to urge that the University charge a very low royalty rate (no more than 0.5 percent) for such licenses. I strongly support the view that the University license rate should be low enough to encourage industrial organizations to sign up, rather than fight the very broad patent or take their operations outside of the United States where the patent does not apply. The more companies that sign up, the more unlikely it will be that other organizations will be inclined to challenge the patent or will be successful in doing so . . . the basic patent underlies an entire industry having enormous potential for generating income for the University. . . . with even a 0.5 percent royalty, the University will do well, and will in fact maximize the likelihood of financial success with the patent . . . "

    Two-page news release "mailed December 3, 1980" from Stanford University Medical Center News Bureau, no title; first sentence: "A broad patent covering the novel gene splicing and cloning methods developed by scientists at Stanford University School of Medicine and the University of California in San Francisco has been issued by the U.S. Patent Office in Washington.", News Bureau contact Spyros Andreopoulos; at right top of first page "12/3/80" handwritten and "file" handwritten by SNC

    Handwritten memo dated December 2, 1980 from Niels Reimers "TO THE FILE", cc to SNC, "Subject: call from Bert Rowland", in upper right date stamped "DEC 5 1980" and "file" handwritten by SNC; completed text: "Method" patent allowed!-- assigned #4237,224. Product patent appl still in negotiation. Pressure on examiner to complete neg. so patent can be used as reference in other pending gene splicing cases."

    Patent 4,237,224 printed on 7-3/4" X 11-3/8" paper

    Photocopy of Patent 4,237,224 copied onto 8-1/2" X 11" paper; "With best wishes, Stan Cohen" handwritten by SNC at bottom of first page; large post-it on first page has "Hold for letter to Tom Kiley" handwritten by SNC

    Signed two-page letter dated September 4, 1980 from Niels Reimers to M. Mangyo, Mitsubishi Chemical Industries Limited, bcc to SNC and H. Kaplan, in upper right "file" handwritten by SNC and also a date stamp "SEP 8 1980" with the "8" crossed out and "9" written above it; "Thank you for your letter of August 21 with accompanying information describing the Mitsubishi-Kasei Institute of Life Sciences. As you may be aware, we have had patent applications on file in the area of genetic engineering for some time. . . . Pending issuance of those patents for the Cohen/Boyer work, we have not developed licensing plans for subsequent discoveries including the invention by Nunberg, Chang et al (Japanese Patent application #130718/1979). We have found that for patents in the pharmaceutical industry, exclusive licenses usually are necessary to encourage development at private risk to products available to the public. However, for basic discoveries such as the Cohen/Boyer patents, we plan to license them non-exclusively.", also discusses hybridoma technology and upcoming Kaplan, Olsson paper in PNAS, "A patent application is on file, and we plan to issue non-exclusive licenses.", and re question about royalties, "For the basic Cohen/Boyer process, the royalties will be less than 1% ", for hybridoma license "royalties will likely by 2% ", and "For other developments, the royalties will likely be greater as we would anticipate issuing exclusive licenses in many instances."

    Unsigned letter dated August 26, 1980 from Niels J. Reimers to Phil Tracy, Burroughs Wellcome Co., cc to Adrian Arima and SNC, at top is date stamp, "AUG 28 1980" and in upper right "file" handwritten by SNC; text begins, "Attached is the Interferon License Agreement, which you will note includes the changes that we had discussed, except for the "combination product." . . . "; at bottom is typewritten: "blind note to Stan: We need the invention assignment signed by you and your colleagues before we can proceed further. NJR", "Niels" handwritten next to typed "NJR"

    Unsigned two-page letter dated March 6, 1980 from Bertram I. Rowland to Niels J. Reimers, cc to SNC and Boyer, at top is date stamp, "MAR 7 1980" and in upper right "file" handwritten by SNC; "TELECON WITH DICKSON OF NATURE RE: APPLICATION STATUS"; received phone call March 4 from Mr. Dickson of Nature "who indicated he had tried to reach you and had been unable to. He further informed me, that he was inquiring about the status of the patent applications filed on behalf of Cohen-Boyer. . . he believed there was a problem concerning inventorship. I asked him whether he had been in contact with Professing[sic] Helling, to which he did not respond.", Rowland says he believes Dickson had read his letter to Helling, and continues recapping talk "My primary points were that while the Patent Office had raised the issue of authorship, I believed it could be handled in the Patent Office with the Examiner. If we were unsuccessful in that effort, then we might have to go to Court, . . .", told Dickson "Helling had done nothing to support his statement that he was a co-inventor, rather he was acting merely as a spoiler.", also "I further stated, that the situation with molecular biology was an excellent opportunity for the universities to realize some return on their substantial investment in support of research in the area. . . . I reiterated a few times concerning Helling that "Helling is an honorable man." I further requested that I not be quoted in the article. . . Before talking to Mr. Dickson, I think it would be appropriate for you and me to have a conversation."

    Three memos stapled together: 1) Signed memo dated February 12, 1980 from SNC to Niels Reimers, "I have heard several different versions of what the "new policy" for distribution of royalties might be. . . . and that some potential obstacles have arisen to the earlier proposal to have the portion currently received by the University "General Fund" go instead to the School of Medicine. . . . I am reluctant to enter into still another major royalty distribution agreement in the absence of a decision on the royalty matter." asks for info re timetable for resolution, at below typewritten text is handwritten note, not by SNC, "(no encl.) attached only for our info."; 2) Signed memo dated September 14, 1979 from SNC to Donald Kennedy, Provost, cc C. Robertson, A. Michaels, G. Lieberman, L. Crowley, "This memo is to indicate my understanding of your proposal regarding patent royalties." next 16 lines of memo provide details, then "Thus, distribution of patent royalties will continue "as is" except that the current "University" share will go entirely or in major part to the Medical School. On the basis of this above understanding, I am prepared to proceed in good faith with assignment of rights in connection with the Michaels, Robertson, Cohen project."; 3) Signed memo dated September 20, 1979 from Donald Kennedy, Provost to SNC, cc to L. Crowley, G. Lieberman, A. Michaels, C. Robertson, at top is date stamp, "SEP 24 1979" and in upper right "Patent" handwritten by SNC; text: 9/14 memo "is entirely in accord with my understanding of our discussions. I'm fully committed to the actions you list, and I'm glad we're ready to move forward."

    Signed letter dated February 5, 1980 from Bertram I. Rowland to SNC and Boyer, "File" handwritten by SNC in upper right; text: enclosed for signature and return to Rowland are two copies of a Declaration under Rule 131 "which I am sending to each of you simultaneously. The Declaration has already been reviewed by Stanley and is hopefully accurate"; two attachments, 1) unsigned three-page "DECLARATION UNDER RULE 131" with signature lines for SNC and Boyer, 2) five photocopied, undated lab notebook pages with handwritten notes by Annie Chang

    Signed letter dated January 16, 1980 from Bertram I. Rowland to SNC, "returned 1/31/80" handwritten on side and date stamped "JAN 17 1980" in upper right; text: enclosed is a Declaration under Rule 131 "would you please review and see if all the statement I make are correct."; two attachments, 1) photocopy of unsigned three-page "DECLARATION UNDER RULE 131" with signature lines for SNC and Boyer, and handwritten edits by SNC 2) five photocopied, undated lab notebook pages with handwritten notes by Annie Chang.

    9511 Cohen/Boyer patent information, 1981
    Draft of two-page memo dated December 18, 1981 from Niels J. Reimers to SNC, cc at end of memo to Kenneth Melmon, Gerald Lieberman, Larry Crowley, Phil Hanawalt, Donald Kennedy; handwritten at top of first page: "DRAFT STAN -- If this is OK, I'll do a "final": (it isn't possible to transfer funds to gift accounts) Niels 12/21/81" and in SNC's handwriting: "Patent file"; text begins, "Following is the accounting which you requested of the 1981 royalty revenue resulting from licensing of the subject patent and patent application.", also mentions, "The Dean's Fellowship Fund is to be used to establish and support the Bernard Cohen Post-Doctoral Fellowships, in honor of your deceased father."

    Unsigned letter dated December 16, 1981 from Roger G. Ditzel, Office of the Board of Patents, Systemwide Administration to Joseph P. Allen, Intellectual Property Owners, Inc., bcc to Neils Riemers [sic], Herbert Boyer, SNC, in upper right of page "file" handwritten by SNC; nominates Boyer and SNC as "Inventors of the Year", pursuant to a call for nominations in the December 1981, IPO News."; stapled behind letter is photocopy of IPO News, December 1981, p.1 with article "Entries sought for 'Inventor of the Year'", no author listed

    Signed letter dated December 11, 1981 from Bertram I. Rowland to SNC, in upper right date stamped "DEC 12 1981" and "File" handwritten by SNC; text: ". . . Enclosing my proposed response to the patent office", deadline is December 18, " . . . If I do not hear from you by that time, I will automatically mail the response as is."; attached is unsigned 11-page "AMENDMENT" with signature line for Bertram I. Rowland and handwritten edits by SNC (some on back of sheet)

    Signed memo dated December 7, 1981 from SNC to Niels Reimers; request for $62.00 (train and taxi fares) reimbursement for visit to U.S. Patent Office where he spoke with patent examiner Alvin E. Tanenholtz SNC thought discussion "was useful, and hopefully will facilitate the allowance of our claims."; attached is photocopy of December 2, 1981 Amtrak Passenger Receipt for $26.00, signed by SNC

    Photocopy of 1981 INVENTOR OF THE YEAR AWARD from Peninsula Patent Law Association to SNC and Herbert W. Boyer for Patent 4,237,224

    Signed memo dated November 5, 1981 from SNC to Niels Reimers; would like to have royalty "funds received in 1981 credited to my accounts of this year and then transferred to the University funds before December 31."

    Photocopy of article, date stamped at top "OCT 1 1981", "file" handwritten by SNC in upper right, "Stanford to License Gene-Splicing Technique", no byline, Scientists Inst. For Public Information, July-August 1981, p. 6.

    USPTO action cover sheet "DATE MAILED SEP 18 1981" from A.E. Tanenholtz to Bertram I. Rowland; Part I states that "Notice of References Cited by Examiner, PTO-892 is attached, Part II lists pending and rejected claims; two attachments: first a signed six-page opinion dated September 17, 1981 by Alvin E. Tanenholtz, Primary Examiner, and second a two-page Notice of References Cited, listing five references, dated September 14, 1981 and signed by Examiner Tanenholtz

    To Examiner: A.E. Tanenholtz "In re the application of JACK N. NUNBERG, et al, Serial No. 950,100", four-page AMENDMENT signed on behalf of Bertram I. Rowland on June 9, 1981

    Page 22 of 25-pagedisclosure "PROTEIN PRODUCTION AT SYNTHETIC START SITE" described in Row 246 of this spreadsheet; text of P. 22 begins, "WHAT IS CLAIMED IS: 1. A method for providing for the production in a unicellular host of a protein foreign to said host . . . "

    Signed letter dated October 26, 1979 from "(Ms.) Ronni Lipsius, Foreign Department Townsend and Townsend" to Niels J. Reimers; date stamped "STANFORD UNIVERSITY OCT 29 1979 TECHNOLOGY LICENSING"; in upper right of page handwritten "xcc Cohen F ____", date stamped "NOV 1 1979" and "Patent file" handwritten by SNC; text says re "Serial No.: 79302019.9, Filing Date: September 27, 1979, Country: EPO (Belgium,France,W.Germany, Italy, Luxembourg,Netherlands,Sweden & Switzerland) For: Protein Production at Synthetic Start Site", "application has been officially filed and assigned a serial number in the Patent Office of the country indicated."; post-it attached to letter with "Save for my trip east." handwritten by SNC

    Sheet of lined yellow paper with handwriting by SNC, "Pat -- get copy of my original patent & examiner's initial denial--and return to me with the attached. S."; below in another hand, "ribosomonial [sic] start site"

    USPTO action cover sheet re Serial Number 950,100, Filing Date 10/10/78, First Named Applicant Jack H. Nunberg et al" "DATE MAILED OCT 7 1981" from A.E. Tanenholtz to Townsend and Townsend; "This action is made final."; Part I of form is unmarked, Part II lists Claims 6-11 withdrawn and Claims 1-5 rejected; attached is a two-page opinion dated September 16, 1981 by Alvin E. Tanenholtz, Primary Examiner with handwritten notes by SNC

    pp. 23-25 followed by pp. 1-21 of 25-page disclosure "PROTEIN PRODUCTION AT SYNTHETIC START SITE" p. 22 is filed separately and described in Row 238 of this spreadsheet; at top of page 1, "SNC Patent file" handwritten by SNC; p. 1: "BACKGROUND OF THE INVENTION";.2: "SUMMARY OF THE INVENTION", p. 3: "DESCRIPTION OF THE SPECIFIC EMBODIMENTS", p. 13: "EXPERIMENTAL", p. 25: "ABSTRACT OF THE DISCLOSURE"

    Two-pages of graphics, "Applicable Overhead Cost Pools � MDTC of Each Univeristy [sic] Functions = Rate; first page depicts, "PRE- A-21" and second page depicts, "POST- A-21"

    Memo dated September 1, 1981 from Andy Barnes to Niels Reimers, "copies sent by TFM to:" Robert Beyers, Donald Kennedy, Gerald Lieberman, William Massy, Kent Peterson, cc to Stanley Cohen, Roger Ditzel, Laura Hofstadter, OTL Staff, date stamped "SEP 2 1981", "SUBJECT: Cohen-Boyer Gene-Splicing License"; text begins: "Today, the Green Cross Corporation of Osaka, Japan, became the first company to sign our gene-splicing license agreement.", rest of memo provides details

    Signed memo dated August 25, 1981 from SNC to Lawrence G. Crowley, cc: Niels Reimers, "SUBJECT: Inventor's share of royalties from the recombinant DNA patent"; text, "I have been informed by Niels Reimers that the University expects to begin receiving funds during the next several months from firms licensing the recombinant DNA patent. As you know, I have specified that half the inventor's share of royalties be assigned at present to the Dean's Fellowship Fund in the Medical School, and that the other half be assigned to the General Research Fund of the University. I am writing now to ask that the Dean's Fellowship funds received from my patent royalties be used to establish and support the Bernard Cohen Postdoctoral Fellowships. . . . in honor of my deceased father."

    Two photocopies of signed memo dated August 20, 1981 from SNC to Niels Reimers, "SUBJECT: Recombinant DNA patent"; requesting original patent document: "I wondered whether you have followed up with Bert Rowland the possibility that the original patent document issued by the Patent Office on the Recombinant DNA method could be given to me."

    Photocopy of Nature, Vol. 292:485, August 6, 1981, containing article, "Stanford sells gene-splicing licences" by David Dickson; "Boyer Cohen patent" handwritten by SNC at top right

    Photocopy of clipping of article, "Genetics engineers upset by licences," "By the staff of Nature", handwritten at top is "copy--Stan Cohen THE TIMES AUGUST 6, 1981 [no page number provided] TO --> Reimers" and handwritten by SNC in upper right corner: "Patent file"; article begins, "Stanford University, in Palo Alto, California, has startled the new biotechnology industry by advertising for applications for licences to use the patents it hold, jointly with the University of California at Los Angeles [sic], on some of the basic operations of genetic manipulation. The advertisement appears among the small ads in next week's Nature. The legal implications of this development are far from clear. . . "

    Three-page advance of press release draft dated July 29, 1981, "FOR RELEASE MONDAY, AUGUST 3, 1981", Contacts: Bob Beyers or Laura Hofstader, "file" handwritten by SNC at top left; text begins, "An unprecedented effort to license the entire genetic engineering industry for use of its basic scientific technique has been started by Stanford's Office of Technology Licensing."; Stanford president Donald Kennedy quoted, "Funds generated through this licensing program will help replenish the basic research enterprise"; Niels Reimers quoted, "So far as I know, there's no precedent for this sort of license"; two handwritten edits by SNC: 1) "The invention itself stemmed from scientific collaborations begun by Cohen and Boyer in a Waikiki delicatessen in November 1972." changed to " . . . begun by a discussion between Cohen and Boyer in a Waikiki delicatessen . . ." and 2) "At first, Cohen didn't think the basic invention was patentable." changed to ". . . didn't think the basic invention should be patented."

    Unsigned letter dated July 7, 1981 from Andrew C. Barnes to Stephen Goulden, Cetus Corporation, cc to Stan Cohen, date stamped "JUL 9 1981"; "Please find enclosed a copy of the latest draft of the Cohen/Boyer License Agreement for your information. The underlined portions in the agreement indicate items which have changed since the previous draft. . . . we plan to publicly announce the terms of the license at the end of this month."

    Signed memo dated June 24, 1981 from Niels J. Reimers to SNC, in upper right are date stamp "JUN 29 1981" and "file" handwritten by SNC; "This is a very belated reponse [sic] to your request for the "original" of the patent of you and Herb Boyer. I had been advised that we must keep the original on file until the patent expires in the event of disputes regarding the patent. . . . the next time I make contact with a Patent Office official . . . I will see if there is a way around that requirement and let you know what I find out."

    Signed memo dated May 13, 1981 from SNC to Niels Reimers, SUBJECT: DNA Patent, "file" written in upper right (not SNC's handwriting); " . . . Although the rights to this patent have been assigned to the University, as the inventor, I should like to have and keep as a souvenir the patent document itself. . . "

    Signed memo dated May 13, 1981 from SNC to Niels Reimers, CC to L. Crowley, SUBJECT: Royalty Distribution for Recombinant DNA Patent"; text: " . . . Dr. Crowley's approval of the revised distribution of the department share of the recombinant DNA patent income was prospective, and was in the form of a statement he made to me indicating that he would go along with whatever arrangement Ken Melmon and I worked out with each other. My statement to you about Dr. Crowley's approval was not intended to imply that he had reviewed the outcome of the discussions that Ken Melmon and I have held on this matter."

    Signed memo dated April 28, 1981 from Niels J. Reimers to Bob Vandagriff, cc to K. Melmon, L. Crowley, G. Lieberman, K. Carpenter, in upper right "SNC" handwritten by Karen Carpenter and "Patent file" handwritten by SNC; text re royalty distribution, Melmon and SNC have agreed, with approval of Crowley and Lieberman, "that the "department share" should be split equally between the Department of Medicine and the Department of Genetics"; summarizes "distribution of "net revenues" (as net revenues are defined in the attached Agreement Concerning Rights in Invention dated 19 June 1975)."; memo has two attachments: 1) signed memo dated March 27, 1981 from Kenneth L. Melmon to Niels Reimers, cc to Gerald Lieberman, Lawrence G. Crowley, SNC, date stamped "STANFORD UNIVERSITY MAR 31 1981 TECHNOLOGY LICENSING" and in bottom right handwritten (not by SNC) "p. 45 Faculty Handbook"; text relates that Melmon and SNC have "come to a reasonable conclusion that the funds generated from his recombinant DNA patent should be split 50/50 between the Department of Medicine and the Department of Genetics for the indefinite future. My hesitation in regard to the long-term future split with the Department of Genetics was no longer justified when I found that the inventor, indeed, does retain all rights to the patent. . . "; and 2) four-page "AGREEMENT CONCERNING RIGHTS IN INVENTION" dated June 19, 1975 between SNC and the Board of Trustees of the Leland Stanford Junior University, signed by SNC and Niels Reimers, at top right of first page handwritten, "S74-43" and at bottom right "original in safe 7/24/75" (neither written by SNC), on p. 3 refers to "the agreement between Stanford and the Board of Regents [of the University of California] dated August 29, 1975", the Department of Genetics is not mentioned in this document, which says net royalties go 1/3 SNC for distribution equally to Stanford's Research Development Fund and School of Medicine Dean's Fellowship Fund; 1/3 to the Department of Medicine; and the final 1/3 "shall be expended in the discretion of the Board of Trustees to further the objects and purposes of Stanford"

    Signed memo dated February 4, 1981 from Donald Kennedy to SNC, Subject: Cohen-Boyer Patent, date stamped "FEB 6 1981"; Kennedy understands Reimers "has been in touch with you on his views on the royalty rate for licenses", that R's proposal is agreeable to SNC, and" that it has the property of flattening out at 1/2%, as you suggested. I, too, agree to his proposal and I believe that it accomplishes our objective of getting the scientific results out to the world as quickly as possible, and generating a fair return to Stanford."; handwritten by SNC at bottom of page, "Feb. 9, 1981 Discussion with Neils [sic] today indicates that initial royalties are 1% reduced to 0.75% > 10 X 106. Further reduction to 0.5% with higher volume. I indicated that I thought 0.5% across-the-board might be better but am not going to push. SNC"

    Signed memo dated January 30, 1981 from Niels Reimers to SNC, cc to Kenneth L. Melmon, K.J. Carpenter; request that department's share of royalties be divided equally between Depts. Of Genetics and Medicine, "At the present tie, the departmental share of royalties is assigned entirely to the Department of Medicine, although I currently hold appointments in the two departments."

    Signed memo dated January 19, 1981 from Donald Kennedy to SNC, date stamped "JAN 23 1981"; reply to SNC's "memo of December 19th concerning the Cohen-Boyer patent. I welcome your thoughtful advice that Stanford should charge a very low royalty rate for licenses related to this patent. . . . and I am in the process of attempting to get Niels Reimer's view on the right magnitude."

    Issue of The Blue Sheet and its Supplement, Vol. 24, No. 1, January 7, 1981; Upper right of Supplement cover has "Patent file" handwritten by SNC; Supplement contains "COMPLETE TEXT OF STANFORD's DNA PROCESS PATENT", pp. S-2 - S-14.

    9512 Cohen/Boyer patent information, 1982
    Unsigned form letter template from Katharine Ku to "[Adr]", cc to Roger Ditzel - UC, Adrian Arima - SU, Lucy Petitt - NSF, Leroy Randall - HHS, S. Cohen - SU, K. Ku - SU, "file" handwritten by SNC at top right, date stamped "JAN 4 1983", post-it attached with "file" handwritten by SNC, text begins, "We wish to verify the Patent Office has been asked to close the public patent prosecution process on the Cohen/Boyer "product" patent application. . . . your license covers both the issued "process" patent and any patent resulting from the "product" patent application."

    Signed letter dated 15 December 1982 from Peter Newmark, Nature to SNC; text re Helling inventorship claims, concludes, "I am disappointed for our sake but glad for yours that discussion has now been driven underground."

    Signed letter dated 6th December, 1982 from R.S. Crespi, Patents Controller, British Technology Group to Niels Reimers; at top of page handwritten "xcc/incl attach to Cohen Rowland Rosenzweig 3 file S74-43", date stamped "STANFORD UNIVERSITY DEC 10 1982 TECHNOLOGY LICENSING" and in SNC's handwriting "Patent file"; thanks for review of my book which appeared in TIBS, same issue contains "short article of mine on some basic patent points which I have illustrated by reference to Cohen-Boyer. I have tried to be quite neutral on the issues on your case, especially as I am not expert in your law."; attached photocopy of article, "Current issues in patent law" by R.S. Crespi, TIBS, December 1982, page numbers missing

    Photocopy of article, "Biotechnology patent challenged" by Stephen Budiansky, Nature, Vol. 300, p. 303, November 25, 1982; re Robert, in upper right "Patent file" handwritten by SNC

    One-page memo dated November 19, 1982 from Niels J. Reimers to Deborah Shapley, Editor, Nature Magazine, has "file" handwritten by SNC in upper right re Nature article "about Stanford's response (on the "second Cohen-Boyer patent") to the U.S. Patent Office (Nature, 11 November, p. 95), one is struck by the editorializing by the author . . . . the article makes it appear the universities have deliberately sought to exclude Dr. Helling from being a co-inventor. The facts are these.", then presents Stanford's and UC's position; stapled in front of memo is small sheet with OTL letterhead, date stamped "NOV 24 1982", typewritten "11/23/82 To: S. Cohen R. Ditzel B. Rowland For your files" signed K. Ku and handwritten below that: "Dr. Cohen -- I assume you received the full copy of the Response K2"

    Issue of McGraw-Hill's Biotechnology Newswatch, Vol. 2, November 15, 1982; on p. 1 date stamped "NOV 29 1982", handwritten by SNC in upper right is "patent file"; on p. 5 article "Stanford's attorney yields no ground in rebutting rejection of second Cohen-Boyer patent application", no byline, handwritten by SNC in upper right of p. 5 is "patent file"; from 1st paragraph of text, "The response, prepared by Palo Alto patent attorney Bertram Rowland, with some assistance from co-inventor Stanley Cohen, attempts to shoot down the complex legal points raised by patent examiner Alvin Tanenholtz, without conceding a single one of 30 claims the application makes to products that results from the gene-splicing invention."

    Unsigned letter dated November 9, 1982 from Katharine Ku to Editor, Stanford Daily; re November 8 article, "University Reapplying for Cloning Patent" . . . "I would like to correct and clarify a few specific points" then three paragraphs of text; stapled in front of letter is smaller sheet of OTL letterhead date stamped "NOV 15 1982", handwritten, "11/12/82 Dr. Cohen: Here's a copy of the letter I sent to the Editor -- they apparently deleted one paragraph because of lack of space. Niels & I feel it's best to drop the topic at this point -- Hope that is satisfactory to you Kathy Ku"; stapled on top of this is a newspaper clipping, "Cloning patent" by Katharine Ku, which is missing the second paragraph of text from Ku's letter

    Issue of Nature, Vol. 300, November 11-17 1982

    Clipping of article, "University defends patent on gene splicing, cloning", no byline, Campus Report, November 3, 1982, pp. 1,17. " File Cohen-Boyer Patent file" handwritten at top of article by SNC

    Two-page draft of news article on letterhead of Stanford University Medical Center News Bureau with date "Nov. 1, 1982" at end, text contains handwritten spelling corrections (not in SNC's handwriting), the final version of this article appeared in Campus Report on November 3, 1982; handwritten at top "11/1/82", date stamped "NOV 5 1982" and "file" handwritten by SNC; business card of Spyros Andreopoulos stapled to top left; only edits to text are four corrections of typos, not in SNC's handwriting

    Two-page memo on green tissue paper dated October 5, 1982 from Niels Reimers to Arthur Kornberg, handwritten at top right: "Stan -- FYI & ___ [looks like f13]. I think you were one I told a "penicillin myth". Niels 10/20/82; memo starts, "Thank you very much for the loan of In Search of Penicillin by David Wilson. . . . "There is an element of truth also with respect to the anti-patent position of some British scientists, but the ultimate reason patents were not filed was a matter of bureaucracy, not principle. . . . A frequent complaint of U.K. university scientists today is that they must delay publication because of patent matters. As you know, we have not, and will not, ask or encourage Stanford scientists to delay publication."

    Letter dated October 25, 1982 from Bertram I. Rowland to SNC, "File" handwritten by SNC; enclosing "two copies of the declaration we discussed to be filed in the subject application" for review, signature and return; two copies of nine-page "DECLARATION UNDER RULE 132" attached, the first one has handwritten edits by SNC, also attached is manila envelope addressed to Rowland

    Binder clip holding unsigned letter dated October 14, 1982 from Bertram I. Rowland ("dictated but not read") to Niels J. Reimers cc to SNC; enclosed is "proposed draft of a response to the Office Action in the subject application", Dave Hogness "informs me he has documentation which establishes his possession of pSC101 prior to November 4 . . . a declaration by Dave will be added."; attached are amendment and six declarations: 1) 19-page unsigned AMENDMENT with signature line for Rowland and handwritten edits by SNC, 2) unsigned nine-page "DECLARATION UNDER RULE 132" with signature line for SNC, 3) Unsigned two-page "DECLARATION UNDER RULE 132" with signature line for Herbert W. Boyer, 4) Unsigned three-page "DECLARATION UNDER RULE 132" with signature line for Stanley Falkow, with a handwritten comment by SNC, 5) Three-page "DECLARATION UNDER RULE 132" signed October 1, 1982 by Bernard Weisblum, 6) Unsigned three-page "DECLARATION UNDER RULE 132" with signature line for Donald Helinski, 7) Unsigned four-page "DECLARATION UNDER RULE 132" with signature line for Bertram I. Rowland

    Signed letter dated September 14, 1982 form Bertram I. Rowland to SNC, in upper right date stamped "SEP 16 1982" and "file" handwritten by SNC; enclosed is "proposed declaration for use in the subject application in response to the outstanding Office Action. I am meeting with Mr. Tanenholtz on the 23rd, and would like to have in my possession a copy which is generally approved by you"; attached is unsigned nine-page "DECLARATION UNDER RULE 132" with signature line for SNC and handwritten comments by SNC

    Clipping of article, article, "Patent Office Withdraws Cohen-Boyer Plasmid Patent from Slated Issue, Rejects All Claims" by Gerry J. Elman, Genetics Engineering News, Vol. 2, September/October 1982, pp. 1,28-30.

    Memo dated August 16, 1982 from Niels J. Reimers to Julius Krevans, Herbert Boyer, Lawrence Crowley, SNC and Roger Ditzel, in upper right date stamped "AUG 18 1982" and "file" handwritten by SNC; re lunch reservations at California Culinary Academy on October 22 at noon

    August 11, 1982 issue of Campus Report, containing article, "Genetic engineering patent must await further scrutiny," by Deborah Franklin, pp. 7,8;"8/11/82" and "file please" handwritten by SNC at top of p. 7

    Typewritten draft of four-page letter dated August 9, 1982 from SNC to Bert Rowland, cc to Niels Reimers re "Comments on U.S. Patent Office Action of August 2, 1982

    Photocopies of three newspaper articles, stapled together: 1) "Stanford, UC rebuffed in bid for patent," by Karen Klinger, San Jose Mercury, August 6, 1982, pp. 3A,3B; 2) "Questions delay Stanford's genetic engineering patent," by Mary T. Fortney, August 5, 1982, pp. B-1,B-3; 3) "U.S. Turns Down Gene-Splicing Patent Bid," no byline, San Francisco Chronicle, August 6, 1982, p. 28.

    Two-page draft of news article on letterhead of Stanford University Medical Center News Bureau with date "Aug. 5, 1982" at end, text contains handwritten spelling corrections (not in SNC's handwriting), the final version of this article appeared in Campus Report on August 11, 1982; handwritten at top "8/5/82" and "file" handwritten by SNC

    Memo dated August 4, 1982 from Niels J. Reimers to Julius Krevans, Herbert Boyer, Lawrence Crowley, SNC and Roger Ditzel, in upper right date stamped "AUG 9 1982" and handwritten note by SNC, "Pat -- please put on calendar" note also asks about Inventor's Hall of Fame plaques, typed at bottom, "P.S. If you would like a ride to the City, please let me know. Niels"; memo text re lunch reservations at California Culinary Academy on October 22 at 1:00 p.m.

    Letter dated August 2, 1982 from Stephen Budiansky, Washington Reporter to SNC, handwritten by SNC in upper right: "Patent file"; letter written on 5" X 8.5" notepaper with Nature America letterhead which is taped to a blank 8.5" X 11" sheet of paper; "I appreciated your phoning today with your comments on my article in last week's Nature. . . . If you would like to air the points you raised with me before the Nature audience, you are more than welcome to send us a note for the "Correspondence" section."; letter refers to article, "Key biotechnology patent delayed" by Stephen Budiansky, Nature, Vol. 298, July 29, 1982, pp. 409-410.

    USPTO action cover sheet "DATE MAILED AUG 02 1982" from A.E. Tanenholtz to Bertram I. Rowland, in upper right of page "file" handwritten by SNC; Part I states that "Notice of References Cited by Examiner, PTO-892 is attached, Part II lists pending and rejected claims; two attachments: first a signed nine-page opinion by Alvin E. Tanenholtz, Primary Examiner, . . . "the prosecution is reopened to set forth objections and rejections necessitated by the discovery of 1) the Cohen et al, Journal of Bacteriology article, 2) the letter to Dr. Donald Fredrickson from Dr. Stanley N. Cohen, 3) the Nature article of April 3, 1980 and 4) to ascertain further information for basing a judgement on the availability of pSC101." and second a list of Other References by Examiner Tanenholtz

    Two photocopies of article, "Key biotechnology patent delayed" by Stephen Budiansky, Nature, Vol. 298, July 29, 1982, pp. 409-410., one of which has some handwritten notes

    Memo dated June 30, 1982 from Niels J. Reimers to Distribution: Donald Kennedy, William Massy Gerald Lieberman, Kent Peterson, Adrian Arima, Spyros Andreopoulos, Stanley Cohen, Roger Ditzel (UC), Herbert Boyer (UC); An article discussing various "uncertainties" regarding the validity of the Cohen/Boyer patent(s) will appear in the next issue of Biotechnology Newswatch, patent attorney notified by Patent Office that "product" application being withdrawn for further consideration

    Memo dated June 22, 1982 from SNC to Niels Reimers, cc D. Purpura, D. Mendelow, K.J. Carpenter; "Subject: Patent Income"; "At a recent meeting of the Department of Genetics faculty concerns were raised about University policies regarding 1) timing of the crediting of patent income to departmental accounts, and 2) maintenance of a fixed "off-the-top" payment for the Office of Technology Licensing regardless of the amount or duration of patent royalties. . . . I am conveying these views to you in response to a departmental resolution that I do so."; "Kathy Roberts" handwritten at bottom of page

    Letter dated March 18, 1982 from Evretechnika, Patent and Trademark Attorneys, Athens, Greece to SNC offering to file genetic engineering patent in Greece

    Letter dated January 14, 1982 from SNC to Thomas D. Kiley, Genentech, Inc. re "Enclosed is a copy of the Cohen-Boyer patent signed by me."; two attachments: 1) Letter dated March 16, 1981 from Kiley to SNC, date stamped "APR 1 1981", asking SNC to autograph copy of patent already signed by Boyer, handwritten text of January 14, 1982 on front and back of this letter, 2) Unsigned photocopy of Patent 4,237,224, issued Dec. 2, 1980.

    9513 Cohen/Boyer patent information, 1983
    Unsigned letter dated April 15, 1983 from Bertram I. Rowland to Niels J. Reimers, cc to Dr. Cohen and Dr. Boyer, text, "Enclosed for your information are copies of statements filed in the Patent Office by Helling and his attorney"; attached are two letters, 1) signed letter dated March 17, 1983 from James H. Dautremont, Intellectual Property Counsel, The University of Michigan to Honorable Commissioner of Patents and Trademarks; text describes letter from Robert B. Helling seeking to be named a joint inventor of SN959288; 2) signed and notarized letter dated March 16, 1983 from Robert B. Helling to Alvin E. Tanenholtz, Primary Examiner, USPTO, text states Helling's claims to be a joint inventor, notarized by Mike Dutzer on March 18, 1983, no attachments to Helling's letter

    Signed letter from Peter Matlock to Stephen Jones, Austgen-Biojet, Re: S74, "Gene-splicing and S80-131, "Bioconversion Reactor", cc to P. McCarty, A. Bachmann, S. Cohen, K. Ku, in upper right date stamped "APR 22 1983" and handwritten by SNC, "Cohen-Boyer patent"; text includes, "If Austgen-Biojet is no longer interested in either of these technologies, then please inform us so that we may make alternate arrangements."

    Signed letter dated April 19, 1983 from Bertram I. Rowland to SNC, "Enclosed is the latest revised declaration for your signature."; attached is six-page "DECLARATION" signed by SNC on April 20, 1983

    Signed letter dated April 13, 1983 from Bertram I. Rowland to SNC and Boyer, "file" handwritten by SNC at top; text begins, "Enclosed for your review and comments are a draft of the proposed amendment in the subject case and copies of the three declarations that will accompany it."; attached unsigned six-page SNC Declaration has handwritten edits by SNC on pp. 1,5

    Unsigned four-page David Hogness "DECLARATION UNDER RULE 132"; handwritten by SNC at top of first page, "where does he ___ Adv each of ____ to practice"

    Unsigned six-page SNC "DECLARATION"

    Unsigned four-page Boyer "DECLARATION"

    Unsigned 32-page "AMENDMENT" with signature line for Bertram I. Rowland; paper clipped behind it is unsigned six-page SNC "DECLARATION"; both documents have handwritten edits by SNC

    Signed letter dated March 4, 1983 from Katharine Ku to David Milligan, Abbott Laboratories; text contains summary by Ku for licensees of recently received Patent Office Action "on the pending "product" patent application"; in upper right, "Cohen" handwritten, date stamp, "MAR 07 1983", and "Cohen-Boyer patent file" handwritten by SNC

    Signed three-page letter dated March 9, 1983 from SNC to Bertram Rowland, "The following is my response to the questions raised by Mr. Rannenholz [sic] in the U.S. Patent Office Action as of January 21, 1983."; no attachments

    Signed letter dated February 28, 1983 from Katharine Ku to Jack Feather, The Cambridge Plan; in upper right "S. Cohen" handwritten, and in SNC's handwriting, "Cohen-Boyer patent file"; text begins, "We would like to acknowledge receipt of Cambridge Plan's letter of intent to terminate the License Agreement governing patent rights under U.S. patent No. 4,237,224."

    Unsigned form letter template from Katharine Ku to "[Adr]", "chron" handwritten at top right, "FEB 25 1983" date stamped, post-it attached with "Cohen-Boyer Patent file" handwritten by SNC, stapled to front of letter is small note signed Kathy Ku, "2/23/83 Prof. Cohen: Thought you might like to see this royalty calculation form. So far, 54 licensees have paid . . ."; text of form letter begins, "Enclosed is a one-page reporting form for calculating royalties for 1982. . . . Since this is the first use of this reporting form, we would appreciate your reviewing it carefully."; attached are two copies of the yellow one-page form, "Determination of Royalties (Recombinant DNA License" for Calendar Year 1982, form #TL-101

    USPTO cover sheet form mailed January 21, 1983, responsive to communication filed on "Nov. 1 and 4 1982": Part I: "Notice of References Cited by Examiner, PTO-892", "Notice of Art Cited by Applicant, PTO-1449, and "Interview summary with Mr. Deutremont [sic] and copy of letter to Robert B. Helling" and Part II lists claims pending and rejected; stapled to the front of cover sheet is large post-it with handwriting "From: Bert Rowland For: Dr. Stanley Cohen 1-24-83" crossed out and in SNC's handwriting, "Patent file", date stamped "JAN 25 1983"; stapled behind cover sheet are six documents listed in the rows below

    First document stapled behind cover sheet is a 12-page opinion with stamp at end, "ALVIN E. TANENHOLTZ PRIMARY EXAMINER ART UNIT 172"

    Second document stapled behind cover sheet is undated, unsigned letter on USPTO stationery from Alvin E. Tanenholtz to Robert B. Helling, cc to James H. Deutremont [sic] and Bertram R. [sic] Rowland, letter has three paragraphs of questions for Helling

    Third document stapled behind cover sheet is Examiner Interview Summary Record regarding phone interview of Bert Rowland on November 16, 1982, signed by Alvin E. Tanenholtz, re Helling inventorship claim, also "Told him I am still weighing the impact of the Hogness possession of pSC101 prior to statutory bar date."

    Fourth document stapled behind cover sheet is a one-page summary of "Telephone Call to Alvin E. Tanenholtz from James H. Deutremont [sic] on November 23, 1982 regarding SN 959,288"

    Fifth document stapled behind cover sheet is a Notice of References Cited, listing Wensick et al., 1974 and signed "Tanenholtz 1/20/83"

    Sixth and last document stapled behind cover sheet is a List of Prior Art Cited by Applicant listing Lederberg, J., Toward Century 21: Technology, Society, and Human Values, pp. 39-52, 1970

    Signed letter dated January 17, 1983 from Katharine Ku to David Milligan, Abbott Laboratories, "Prof. Cohen" and "cohn/Boyer" [sic] handwritten at top, date stamped "JAN 20 1983"; 1983 annual royalties due by February 1" and FYI, " . . . We have not yet received any official action from the Patent Office to our November 1, 1982 response for the DNA "product" patent application."

    9514 Cohen/Boyer patent information, 1983
    Handwritten "MEMO TO THE FILE" dated 12/21/83 from K2 to S74-43, cc to S. Cohen, UC re DNA Cloning; in upper right date stamped "DEC 27 1983" and "file" written by SNC; text: "Per Bert: "Formal matters re BR will be resolved early Jan -- Will likely receive Notice of Allowance in Feb Will possibly/probably get issued patent in March"

    Four sheets of paper stapled together: 1) Unsigned letter from Katharine Ku to Daniel P. Weingarten, GIBCO Laboratories, Life Technologies, Inc., in upper right "S. Cohen" handwritten, stamped "DEC 29 1983" and "file" written by SNC; text: "We were surprised and puzzled by your letter of December 16. . . . All the current issues surrounding the pending patent application have been resolved."; 2) Signed letter dated December 16, 1983 from Weingarten to Neils [sic] Reimers, cc to M.J. Barrett, Ph.D. and K.E. Blackman, Ph.D.; in upper right, date stamped "DEC 29 1983" and below that stamped 'STANFORD UNIVERSITY DEC 20 1983 TECHNOLOGY LICENSING"; "I have spoken to Dr. Barrett about some of the issues you raised in our meeting in early October regarding the Cohen-Boyer patent. dr. Barrett called to my attention a letter he wrote to you dated January 7, 1983, which pointed out several significant errors in the submission by the authors under rule 131." asks if issues resolved; 3) Unsigned letter dated June 17, 1983 from Katharine Ku to James Barrett, President, Bethesda Research Laboratories, "file" written in top right, " . . . I had wanted to have the opportunity to respond in person to your letter of June 7, 1983, regarding the DNA cloning patent. The attorney handling the prosecution brought the information you presented forward to the Patent Office. It is now part of the record. For your information, I have excerpted the relevant portion from the recent response."; 4) Photocopy of 14 lines of printed text, handwritten in upper right is "Excerpt from Response to Jan 21, 1983 Office Action", text, "It is noted that consideration of the declaration under Rule 131 has been held in abeyance. . . . The error has to do with referring to pSC101, where the results which are reported refer to pSC105. However, once the issue concerning Professor Helling's inventorship is resolved, the declaration becomes moot, since the articles coauthored by Professor Helling would no longer be relevant. . . ."

    Two stapled stacks of paper that have been paper-clipped together: 1) Legal documents: log sheet identical to one in second stack, except that this sheet has one newer activity, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, "Amendment / Petition to make special" Official Date and Forwarded to Client 9-20-83, in upper right stamped "STANFORD UNIVERSITY SEP 22 1983 TECHNOLOGY LICENSING", handwritten "Roger Stanley", date stamped "SEP 28 1983" and handwritten by SNC: "file Cohen-Boyer patent"; attached are two USPTO Forms, both signed by Bertram I. Rowland on September 20, 1983: five-page AMENDMENT "Cancel Claims 18, 20-22, 24-28, 30-37, 64, 77, 78, and 80-87, without prejudice to their renewal and in light of the following claims." then adds Claims 88-98; also attached is two-page PETITION TO MAKE SPECIAL 37 CRF [sic] �1.102, " . . .to make the application special, to allow for early issuance. As the Commission is aware, this application has assumed extreme public interest. . . . Furthermore, a number of novel issues were raised during the prosecution, which issues may help other patent counsel to evaluate patentable subject matter in the rapidly growing field of recombinant DNA technology. Also, this application was previously allowed, and allowance withdrawn at the last moment."

    Two stapled stacks of paper that have been paper-clipped together: 2) second stapled stack of paper has cover sheet identical to the one mentioned above, except that there is one fewer line on the log sheet; newest item is "Office Action", Official Date 9-30-83, Forwarded to Client 9-16-83; stapled to log sheet is USPTO Form responsive to communication filed on 4/28/83 and 7/5/83, "Notice of References Cited by Examiner, PTO-892" and "Examiner Interview Summary Record"; lists pending, cancelled, allowed, and rejected claims, with four pages of details, list of references: Lobban thesis, 1972 and Hogness, 1975

    Photocopy of article, "New Technique to Produce Proteins May Alter Biotechnology Industry," by Jerry E. Bishop, Wall Street Journal, November 10, 1983, page unknown; at top of page, handwritten {looks like Ku's handwriting}: "- not plasmid - no replication system - DNA doesn't replicate", and "11/2/83 Stanley: Niels said you'd like copy of this -- sounds fishy, eh? Kathy", date stamped "DEC 6 1983", "Cohen-Boyer patent file" handwritten by SNC; article describes new technique by Fred Russell Kramer of Columbia

    Unsigned, undated form letter from Katharine Ku to DNA Licensees; handwritten at top; "Subject: License Agreement Between [1] and Stanford University Covering U.S. Patent No. 4,237,224 By Stanley N. Cohen and Herbert Boyer"; letter begins, "We wish to bring you up to date with respect to the prosecution of Patent Application Serial No. 959,288, the "product" application relating to the DNA cloning methods described in the U.S. patent indicated above. The Patent Office has notified us that the claims which cover recombinant plasmids and other vectors able to replicate in prokaryotic host organisms are allowable."; text also includes, "In a continuation application, we will continue prosecution with the Patent Office of claims with respect to yeast and other eukaryotic unicellular organisms as hosts. . . . An attachment lists the claims of the application that have been deemed allowable."; attached are unsigned letter dated December 12, 1983 with handwritten edits and writing at top of page, "Stanley - Please make the appropriate changes ASAP. Thanks. -- K." and written in SNC's handwriting, "Cohen/Boyer patent file" and two-page document listing Claims 88-98

    Letter dated November 18, 1983 under letterhead of "Law Offices of Wegner & Bretschneider" in Washington, DC, which closes "Respectfully submitted, HAROLD C. WEGNER, PETITIONER by Ronald R. Snider Reg. No. 24,962 (signed by Snider)" to "Hon. Commissioner of Patents and Trademarks" requesting immediate decision re having patent file opened; attached are 1) memo dated September 14, 1983 from Linda S. Paine to Harold C. Wegner, "In summary, Mr. Tarring of the PTO Solicitor's Office had no firm idea of when he would review the Petition, but indicated that the status should be checked again in October." and 2) a page from 37 CFR [sic] �1.114 with underlining of "If there is no objection the petitioner is permitted to see the entire parent application"

    Legal documents: log sheet, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, newest item is "Notice of Allowability", Official Date 10-11-83 and Forwarded to Client 10-18-83, in upper right stamped "STANFORD UNIVERSITY OCT 19 1983 TECHNOLOGY LICENSING", handwritten "cc: S. Cohen T. Crotte", date stamped "OCT 21 1983" and handwritten by SNC: "file"; attached are USPTO Form signed by primary examiner Alvin E. Tanenholtz allowing Claims 88-98, a one-page "Examiner's Amendment to the record" and "Examiner Interview Summary record that interview occurred 10/6/83 of Bert Rowland by Al Tanenholtz

    Legal documents: log sheet, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, newest item is "Decision on Petition filed 9/21/83", Official Date 9-30-83 and Forwarded to Client 10-19-83, in upper right stamped "STANFORD UNIVERSITY OCT 20 1983 TECHNOLOGY LICENSING", handwritten "cc: S. Cohen", date stamped "OCT 26 1983" and handwritten by SNC: "file"; attached "Decision on Petition Filed September 21, 1983", mailed September 30, 1983, signed by Robert F. White of USPTO, "applicants' petition is hereby granted", Rowland's name and address typed at bottom of page

    Signed letter dated March 17, 1983 from James H. Dautremont, Intellectual Property Counsel, The University of Michigan to Honorable Commissioner of Patents and Trademarks, front page has large red "CONFIDENTIAL" stamp; text describes letter from Robert B. Helling seeking to be named a joint inventor of SN959288; attached signed and notarized letter dated March 16, 1983 from Robert B. Helling to Alvin E. Tanenholtz, Primary Examiner, USPTO, front page has large red "CONFIDENTIAL" stamp, text states Helling's claims to be a joint inventor, notarized by Mike Dutzer on March 18, 1983, no attachments to Helling's letter

    Legal documents: log sheet, for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, newest item is "Office Action", Official Date 8-30-83 and Forwarded to Client 9-69-83, in upper right stamped "STANFORD UNIVERSITY SEP 20 1983 TECHNOLOGY LICENSING", date stamped SEP 22 1983" and handwritten by SNC: "File Cohen-Boyer patent"; attached USPTO Form responsive to communication filed on 4/28/83 and 7/5/83, "Notice of References Cited by Examiner, PTO-892" and "Examiner Interview Summary Record"; lists pending, cancelled, allowed, and rejected claims, with five pages of details, list of references: Lobban thesis, 1972 and Hogness, 1975

    Signed letter dated September 7, 1983 from SNC to Bertram I. Rowland, "Enclosed is a reprint of my 1975 paper describing the co-transformation procedure claimed in the Columbia University patent. I think you will agree that the paper is pretty explicit in anticipating what Science and Nature report as Columbia's claims."; no enclosure

    Unsigned 10-page letter under letterhead of "Law Offices of Wegner & Bretschneider" in Washington, DC from "Harold C. Wegner Reg. No. 25,258" to Honorable Commissioner of Patents and Trademarks, Attn: Solicitor (Henry Tarring, Esq.; Katharine Ku's business card stapled to top of first page and handwritten "Stanley Cohen", on top right of first page date stamped "AUG 29 1983" and handwritten by SNC "Cohen-Boyer patent"; letter text begins, "This is a request under 37 CFR �1.14(e)(2) for access to United States patent application Serial No. 959,288"

    Signed letter dated August 4, 1983 from Katharine Ku to Daniel P. Weingarten, GIBCO Division, The Dexter Corporation, "Re: Stanford Docket S74-43, "DNA Cloning"" and "Stanford Docket S82-64, "DNA Hybridization Probes"; offers GIBCO/Dexter "a license to the Cohen/Boyer DNA cloning invention; particularly since Dexter recently acquired Bethesda Research Laboratories, we feel that BRL's and/or Dexter's activities no doubt involve recombinant DNA."

    Signed letter from Katharine Ku to Brian McCarthy, California Biotechnology Inc., cc: J. Newman, M. Petit, S. Falkow, T. Merigan, F. Murad; in upper right, "S. Cohen" handwritten, date stamped "AUG 9 1983" and handwritten by SNC, "Cohen/Boyer patent"; text, "Stanford has many technologies which CBI may be interested in licensing," including "Stanford Docket S82-64, "DNA Hybridization Probes"; no attachment

    Photocopy of a page from New Scientist, June 30, 1983 with article, "Decision due in billion-dollar patent row," by Barry Fox; stapled to front is small handwritten note, "7/11/83 Stanley: In case you haven't seen -- this article is just trying to sensationalize a non-issue (Ziff). Kathy", note date-stamped "JUL 14 1983" and handwritten by SNC, "Cohen/Boyer patent file"; article begins, "The US Patent Office will decide sometime in the coming month whether a short article, published in New Scientist 10 years ago, invalidates potentially the most valuable patent application ever filed."

    Unsigned two-page form letter from Katharine Ku to "[Adr]" ; "Re: License Agreement covering Cohen/Boyer DNA Cloning Invention; U.S. Patent No. 4,237,224 and Application Serial No. 959,288; handwritten at top, "5/19 Stanley -- Is this acceptable? Please let me know if you have changes -- Kathy"; in SNC's handwriting, "not satisfactory -- file I have spoken with Kathy Ku" and handwritten comments by SNC and Ku; text begins, "We have recently submitted Stanford's Response to the present Office Action on pending patent application serial No. 959,288. The main points of the Office Action and the Response are summarized below"

    Binder clip holding four documents. First document is 33-page "AMENDMENT" signed by Bertram I. Rowland on April 27, 1983

    Binder clip holding numerous documents. Second document is six-page "DECLARATION" signed by SNC on April 20, 1983; attached are SNC articles, "The Stanford DNA Cloning Patent", 1982; "The manipulation of genes," 1975; "The transplantation and manipulation of genes in microorganisms," 1980;

    Binder clip holding numerous documents. Third document is four-page "DECLARATION" signed by Herbert W. Boyer on April 19, 1983

    Binder clip holding numerous documents. Fourth document is four-page "DECLARATION UNDER RULE 132" signed by David S. Hogness on April 26, 1983.

    9515 Cohen/Boyer patent information, 1984
    News release dated August 28, 1984 from Stanford University Medical Center News Bureau, "Cohen-Boyer Genetic Engineering Products Patent Issues" News Bureau contact Laura Hofstadter; handwritten note stapled to first page "8/31/84 Stan: In case you didn't get this--Congratulations! Kathy"; post-it attached to first page, "file - Cohen/Boyer patent" handwritten by SNC

    Letter dated December 31, 1984 from Katharine Ku to Mr. Lewin, Agricultural Genetics Co., Ltd. "Re: Stanford Docket S74-043, "DNA Cloning", "We are very pleased that Agricultural Genetics has decided to become a licensee"

    Letter dated December 13, 1984 from Katharine Ku to Albert P. Halluin, Cetus Corporation "Re: Stanford Docket S74-043, "DNA Cloning"; "In response to your letter of December 3, 1984, the pending patent application claiming recombinant plasmids in unicellular eukaryotic hosts are covered by the original License Agreement. . . . The post-termination responsibilities of a licensee are detailed in Paragraph 8.6 of the License Agreement; no other residual rights or obligations rest with the licensee, including credits."; December 3, 1984 letter is attached

    Clipping of article, "Cohen-Boyer Plasmid Patent: An Analysis of the Issues" by Bruni Kobbe, Genetic Engineering News, November/December 1984, pp. 3,11; post-it attached to first page, "Cohen/Boyer patent file" handwritten by SNC

    Letter dated November 15, 1984 from Katharine Ku to Roger Ditzel, Patent, Trademark & Copyright Office, University of California, cc H. Boyer and SNC; "Re: Stanford Docket S74-043, "DNA Cloning", "this letter serves as the annual report setting forth the status of patent prosecution, commercial development, and licensing activity for the fiscal year ended August 31, 1984"

    Letter dated December 31, 1984 from Katharine Ku to Donald Perella, Merck & Co, Inc. "Re: Stanford Docket S74-043, "DNA Cloning", "We are very pleased that Merck intends to become a licensee"

    Letter dated December 31, 1984 from Katharine Ku to James Barrett, Bethesda Research Laboratories, Inc. "Re: Stanford Docket S74-043, "DNA Cloning", "We are very pleased that BRL/Life Technologies intends to become a licensee"

    Photocopy of article "Cohen-Boyer Patent Finally Issued", by Colin Norman, Science, September 14, 1984, p. 1134.

    Genetics Technology News, Vol. 4, No. 10, October 1984; "Second Cohen-Boyer Patent Issues", p. 1, no byline, five paragraphs; patent name, number an issue date listed in "Patents" section on p. 11

    Photocopy of New Scientist, September 6, 1984, p. 7, containing article, "Gene patent granted: now the real fight begins", by Ian Anderson; "Millions of dollars are at stake, not to mention the future organisation of the genetic engineering industry."

    Memo dated May 18, 1984 from Niels J. Reimers to "P. Berg, S. Cohen, A. Kornberg, J. Lieberman, D. Purpura, and I. Weissman", "SUBJECT: "Limits in the Handling of Genetic Engineering"; met with Wolf-Michael Catenhusen, of German Bundestag, involved with "special Bundestag committee set up to deal with "problems relating to new biotechniques." I thought you would be interested in the preliminary report of his committee . . . . Rather than leave the field to Jeremy Rifkin by default, a position paper by those involved in the field, perhaps along the line of Mr. Catenhusen's report, might be worth considering."; attached report (in English)

    Letter dated May 16, 1984 from Dorothy Hinden, NIAID to SNC and Fred A. Gustafson, Stanford Sponsored Projects Office; "Frank E. Robbins, Law Office of Robbins and Laramie, Washington, D.C., has requested a copy of your successful grant applications and progress reports from 1969 to 1976 for R01-AI08619 to be used by Mr. Robbins in an evaluation of United States Patent 4,237,224 . . . Please advise us of any portions of your proposal that you believe should be withheld under the exemptions provided by the [Freedom of Information] Act." attached two-page printout "FOIA EXEMPTIONS USUALLY APPLICABLE TO GRANT INFORMATION"

    Published copy of Patent 4,468,464, Date of Patent: August 28, 1984

    Photocopy of article, "A patent on everything", no byline, The Economist, September 8, 1984, pp. 72,75. "The latest--and so far two most important--patents are so broad that other companies could be shut out of the industry unless they license the technology or take on an expensive legal fight."

    Form letter template from Katharine Ku containing handwritten date "9/6/84" and handwritten note "9/6/84 Stan: If you're interested in the list of companies we are contacting, here 'tis. K" letter text says Patent 4,468,464 issued on August 28, 1984; "We understand that ___ has been using the basic technology of recombinant DNA in your research and development.", invites them to become licensees; attached to letter is 29-page "DNA Form Letter A Address List"

    Issue of Science News, Vol. 126, September 8, 1984; stapled to front is note from editor Joel Greenberg, "You may be interested in the article on page 150 Any comments would be welcome."; attached to note is post-it with "Cohen/Boyer patent file" handwritten by SNC; article "Gene engineering: Patent for products" by J. A. Miller on p. 150

    Two copies of Patent 4,468,464, with attached handwritten note referring to three copies, "9/4/84 Stan: Here are 3 copies for your file. I'm so excited that we got the hard copies -- Kathy"

    Draft of news release from Stanford University Medical Center News Bureau, on first page of draft "Cohen/Boyer patent file" handwritten by SNC; "Cohen-Boyer Genetic Engineering Products Patent Issues", News Bureau contact Laura Hofstadter; small note attached to first page, "8-28-84 To Stan Cohen From Laura Hofstadter Draft attached of news release final version"

    Draft of news release from Stanford University Medical Center News Bureau about newly issued Patent; small note attached to first page, "7-27-84 To Stan Cohen From Laura Hofstadter The latest version" with "file" handwritten by SNC; news release begins, "A patent covering genetically engineered molecules that can be used to generate biological products was issued today (Aug. 7)"; patent was issued August 28, 1984

    Draft of news release from Stanford University Medical Center News Bureau about newly issued Patent; small note attached to first page, "July 19, 1984 To Stan Cohen From Laura Hofstadter This draft incorporates the changes you suggested. My notes from a discussion with Bert Rowland indicate that the patent does state plasmid explicitly, though he thinks it means any circular piece of DNA with a replication system and a structural gene from a source that doesn't normally exchange information with the host that recognizes that replication system. Would this mean viral vectors are included? L"; draft contains numerous handwritten comments by SNC

    Draft of news release from Stanford University Medical Center News Bureau about newly issued Patent; letter clipped to front of draft: dated July 18, 1984 from Katharine Ku to Frank Adams, UOP, Inc., states minimum annual advance for 1984 not yet received, "this letter serves as written notice of termination to UOP by Stanford, effective October 15, 1984"; small note clipped to front of letter refers to the news release draft behind the letter; note reads, "July 17, 1984 To Stan Cohen From Laura Hofstadter In anticipation of news interest when the new patent is issued, I've drafted this news release. Niels, Kathy and Bert have already seen it. Please let me know if you find any factual errors--Thanks"

    Letter dated June 27, 1984 from Katharine Ku to John Chester, National Science Foundation, at upper right of letter "File Cohen/Boyer patent" handwritten by SNC; "Thank you for your call in April, informing us of the request by Robbins and Laramie for information under FOIA . . . . As we discussed, there does not seem to be anything in the file that would be confidential. For your information, we expect the product patent to issue August 7 with U.S. Patent No. 4,464,473."; handwritten note at bottom of letter, "7/6/84 Stan: Niels said you were concerned about this letter. Chester reassured us that he would keep the information confidential. I'm sorry that I told him (in light of your reaction) but since NSF is a "sponsor", I had thought it was appropriate. I shall keep quiet till Aug 7! K."

    Letter dated June 27, 1984 from Katharine Ku to John Chester, National Science Foundation, handwritten note in upper right, "Stanley Cohen FYI -- K2 " and "Cohen/Boyer patent file" handwritten by SNC; "Thank you for your call in April, informing us of the request by Robbins and Laramie for information under FOIA . . . . As we discussed, there does not seem to be anything in the file that would be confidential. For your information, we expect the product patent to issue August 7 with U.S. Patent No. 4,464,473."

    Photocopy of "Gene Splicers Square Off in Patent Courts" by Jeffrey L. Fox, Science, Vol. 224: 584-586.; in upper left of page one "Cohen/Boyer patent file" handwritten by SNC

    Legal documents: log sheet for CLIENT: Stanford University, TITLE: PROCESS AND COMPOSITIONS FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS, notice of Allowance and Request for Expedition, Official Date and Forwarded to Client 4-18-84; attached two-page USPTO Form, "Notice of Allowance and Issue Fee Due", addressed to Bertram I. Rowland, Issue Fee Due July 5, 1984, SC/Serial No. 05/959,288, Fee Due: $500.00; behind form is one-page "REQUEST FOR EXPEDITION", "for the following reasons: 1. This application has been made special due to its early filing date and its national importance; and 2. there have been numerous requests for public access to the file wrapper.", signed by Bertram I. Rowland on April 18, 1984

    DECISION REFUSING REJECTION UNDER 37 CFR STAMPED, "COPY MAILED MAR 29 1984 COMMISSIONER'S OFFICE" Re Serial No. 05/959,288, "Dr. Helling's Assertion of Inventorship" and "The Inaccuracy Regarding The Method For Preparing Plasmid pSC101"; signed by Alfred L. Leavitt, Special Program Examiner and initialed by Conferee M.A. Antonakas

    Handwritten note, "3/21/84 Bert says it's still in Leavitt's group ? to Tanenholtz by End of Month -- means we hope to get Notice of Allowance in May and will maybe issue in July or August. Sigh. K"

    Letter dated March 15, 1984 from Roger G. Ditzel, Director of Patent, Trademark and Copyright Office at University of California to Katharine Ku, cc to SNC and Herbert W. Boyer; re Amendment No. 1 to Agreement Concerning Administration of Rights in Invention is enclosed. "The effective date of this Amendment is March 1, 1984."; no attachment

    Letter dated March 14, 1984 from Katharine Ku to Albert P. Halluin, Cetus Corporation; refers to Halluin letter of February 27, "You expressed concerns about the validity/enforceability and scope of the claims of U.S. Serial No. 959,288."; attached are February 27, 1984 letter from Halluin to Ku and three drafts of a response from Ku, each draft with a note to SNC asking for his feedback

    Letter dated March 7, 1984 from Katharine Ku to Roger Ditzel, "Re: Stanford Docket S74-43, "DNA Cloning", re Amendment No. 1 to Agreement Concerning Administration of Rights in Invention enclosed for UC signature; Amendment attached

    Memo dated February 1, 1984 from Nancy Holt to Bert Rowland, "Enclosed is the signed declaration of Stan Cohen regarding" Biologically Functional Molecular Chimeras; attached to memo are signed letter dated January 30, 1984 from Bertram Rowland to SNC, "Enclosed for your signature is a ribbon copy of your declaration, revised in accordance with your changes of January 27, 1984." and three-page "DECLARATION OF STANLEY N. COHEN" re pSC101 signed by SNC on February 1, 1984

    Binder clip holding numerous documents. First is memo dated January 27, 1984 from Nancy Holt to Bert Rowland, "Enclosed is the declaration for BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS as Stan Cohen has edited it; attached are two drafts of first two pages of declaration, one with extensive handwritten edits by SNC; after memo is letter dated January 25, 1984 from Bertram I. Rowland to SNC and Herbert Boyer, "Enclosed for your review and comments is the proposed response to be filed in the subject application." with three attachments, all of which are unsigned: 1) p. 3 of SNC Declaration (pp. 1-2 probably pages with handwritten edits), 2) two-page Boyer Declaration, 3) and 10-page "RESPONSE TO REQUIREMENT FOR INFORMATION" which begins, "In response to the Requirement for Information of January 6, 1984" and ends with signature line for Rowland. Letter dated December 16, 1977 from Bertram I. Rowland to Niels Reimers, cc SNC, recapping Rowland's interview with patent examiner Alvin E. Tanenholtz, ". . . while he was willing to allow claims which describe a basic method for producing transformants, he was not willing to allow any of the other claims" and mentions new work that questions whether pSC101 was the vector, "As to this matter as well as other matters, consideration should be given whether we should revise the application before refiling it as to the plasmid claims." Unsigned copies, with no attachments, of a January 20, 1975 form letter from Rowland to each of the following: Robert B. Helling, John F. Morrow, Annie C.Y. Chang, Charles Yanofsky, Howard M. Goodman, Vickers Hershfield, Michael A. Lovett, Donald R. Helinski, re "Pat. appln. for PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS - S. Cohen and H. Boyer . . . . You are a co-author and, therefore, I am requesting your cooperation in signing the accompanying disclaimer, disclaiming being a co-inventor." Unsigned copies of a January 28, 1975 form letter from Rowland to each of the following: Robert B. Helling, Annie C.Y. Chang, Charles Yanofsky, Howard M. Goodman, Vickers Hershfield, Donald R. Helinski, Michael A. Lovett, and John F. Morrow, each letter has a cc to SNC and Boyer, re "Pat. appln. for PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR DNA CHIMERAS - S. Cohen and H. Boyer"; "My prior letter has apparently been subject to an unintended misunderstanding. . . . In using the term "on behalf of" I intended that Professors Cohen and Boyer were the inventors, but did not intend that I was employed by them. The request for a patent application was initiated by Stanford University and the University of California who are the assignees and have the financial interest in the patent application. As I am sure you are well aware, the Universities are sorely stressed for funds and the patenting of research developments which have commercial potential is becoming an avenue for obtaining additional funds. In recognition of the needs of the University, when the research is funded by governmental agencies, the government normally allows the Universities to license patents covering government-sponsored research and receive the funds. . . . The issuance of the subject patent will in no wise inhibit any researcher, either academic or commercial, from carrying out additional research in the areas covered by the patent. Should a development be commercialized and come within the ambit of the subject patent, Stanford and UC would have the opportunity to receive royalties from such commercial use. I am enclosing a copy of the letter sent to me by Stan Cohen explaining his understanding of the purpose and intent of the Universities in filing the subject patent application. I would also like to add that prior to becoming a patent attorney, I received my doctorate in organic chemistry and was employed as a research chemist. I am personally sensitive to the interest and the needs of the academic community and am appreciative of their concerns."

    9516 Cohen/Boyer patent information, 1985
    SECOND PRELIMINARY AMENDMENT re "PROCESS AND COMPOSITION FOR BIOLOGICALLY FUNCTIONAL MOLECULAR CHIMERAS", 24 pp., signature line on p. 24 is unsigned; text has handwritten comments by SNC

    Memo dated November 8, 1985 from SNC to Kathy Ku; "Enclosed is a recent advertisement from Promega Biotech . . . I would imagine that this product falls under the Stanford patent, along with some of their other products--notwithstanding their claims to the contrary."; Attached photocopy of one-page ad for "ProtoBlotTM Immunoscreening System"

    Two-page news release dated April 15, 1985 from Stanford University Medical Center News Bureau, on first page "4/21 Stan FYI - K2" handwritten in upper right, also "Cohen/Boyer file" handwritten by SNC; title: "11 Companies Sign on While Four Terminate Licensing Agreement with Stanford", News Bureau contact Laura Hofstadter; release ends, "Following is a list of the licensees as of April 12, 1985", with list of 73 companies

    Letter dated November 1, 1985 from Katharine Ku to Irving Feit, Ciba-Geigy; "We are most pleased that Ciba-Geigy has decided to take the Cohen/Boyer DNA Cloning license . . . . As I mentioned, we are in the process of reevaluating the royalty structure of the Agreement so that this offer expires December 10, 1985."

    Letter dated October 17, 1985 from Katharine Ku to Robert D. Weist, Applied Molecular Genetics, Inc.; Stanford awaiting signed copies of licensing agreement, "As you know, it is important for AmGen to be a licensee, particularly in light of AmGen's sales and advertising of recombinant DNA products and inquiries by other licensees. Adrian Arima, Stanford legal counsel, and I would like to discuss the issues with AmGen representatives to answer any questions of patent scope and interpretation of the license."

    Letter dated December 14, 1984 from Thomas A. Mann, United States Biochemical Corp. to Katharine Ku; re license agreement, ". . . we would be very happy to meet with you to discuss the possible applicability of this patent to any of our activities."; three attachments: 1) handwritten notes "12/17 FG - Do we have info? K" and "9/5 Stan: FYI - I'll follow-up on this."; clipped to letter is OTL memo to file dated 9/6/85 by K Ku re "Telecon c Joe Sorge, Vector is behind schedule re recombinant "construction", in about 4-5 months, they'll be making/developing products and will take a C/B license then", note to SNC, "Stan - As long as Vector is going to take a license, it's probably not economically-wise to press them now. K"; 2) letter dated September 1, 1985 from James C. Gaither, Center for Biotechnology Research to Niels Reimers, OTL re "License Agreements between Stanford University and the Center for Biotechnology Research - Stanford Docket Nos. S81-78 and S81-79", "no significant progress has been made toward commercial use of products in the past year"; 3) cover letter dated August 26, 1985 from James C. Gaither to Niels Reimers re Stanford Docket No. S80-23 with "Quarterly Report Quarter Ended June 30, 1985" re licensed products and sublicenses: none of either

    Letter dated September 3, 1985 from Katharine Ku to Albert P. Halluin, Esq., Cetus Corporation, "Stan Cohen FYI - K" handwritten in upper right, also "Cohen/Boyer patent file" handwritten by SNC; text: " . . . We have agreed to the following policy effective September 3, 1985 for Cetus/Stanford so-assigned inventions," with details; unsigned AGREED AND ACCEPTED signature line for Cetus; attached are letters both dated August 30, 1985 from Katharine Ku to Daniel R. Henderson, Microgenics Corp., and Frederic de Hoffman, Salk Institute Biotechnology/Industrial Associates, Inc. (SIBLA) inviting them to become Cohen/Boyer patent licensees; Microgenics letter: "Microgenics must be pleased to have the distinction of being the first company to receive FDA approval for a recombinant DNA clinical test."; SIBLA letter: "We wrote last year to offer SIBLA a license to the Cohen/Boyer patents but received no response."

    News release dated August 23, 1985 from Stanford University Medical Center News Bureau, "Cetus Corp. Resumes Genetic Engineering License Agreement with Stanford" News Bureau contact Laura Hofstadter; Attn: Neils [sic] Reimers and Kathy Ku, handwritten "To: Stan Cohen" in upper right; Reimers quoted in story, "In effect, the license will continue exactly as before, as if there had been no termination," release also states, "Stanford agreed to reinstate the $250,000 in credits the company had earned.", now 74 licensees, "Over $3.5 million have been received since the licensing program was initiated in 1981."

    Letter dated April 26, 1985 from Julius R. Krevans, M.D., Chancellor of UCSF to President Donald Kennedy of Stanford thanks for arranging luncheon to honor Boyer and Cohn [sic], handwritten note at bottom, "Stan - In case you didn't receive a copy, here 'tis. Kathy"

    Letter dated April 23, 1985 from Niels Reimers to SNC; "By signature below, you agree to return upon our written request, to Stanford, the original of U.S. Patent No. 4,237,224, issued December 2, 1980. If it does become necessary to request the patent, be assured our intent will be to return it to your possession as soon as it is not needed."; AGREED AND ACCEPTED signed by SNC April 27, 1985

    Letter dated November 29, 1984 from Katharine Ku to Allen W. Richmond, Phillips Research Center, "bcc: S. Cohen" handwritten in upper right, also "file - Cohen/Boyer patent" handwritten by SNC; "Re: Stanford Docket S74-43, "DNA Cloning"; "We are most pleased to return one fully executed copy of the License Agreement covering the above referenced invention. . . . Again, both Stanford and the University of California are delighted to have Phillips on board"; no attachment

    Letter dated January 2, 1985 from Katharine Ku to Al. A. Jecminek, Triton Biosciences Inc., handwritten in upper right "Dr. Stan Cohen FYI, Kathy Happy New Year"; "Re: Stanford Docket S74-43, "DNA Cloning"; "We are pleased to return a fully executed copy of the License Agreement covering the Cohen/Boyer patents."; attached are three letters all dated January 2, 1985 from Katharine Ku: 1) to I.V. Karau, BASF Aktiengesellschaft, 2) to Herbert L. Heyneker, Genendor, Inc., and 3) to John H. Newman, California Biotechnology, Inc.; each letter expresses delight the company has become a Cohen/Boyer patent licensee

    Letter dated January 4, 1985 from Katharine Ku to Nan Newell, Calgene, Inc. S. Cohen", handwritten in upper right, also "file" handwritten by SNC; Stanford Docket S74-43, "DNA Cloning", "We are pleased that Calgene has decided to become a licensee of the Cohen-Boyer patents. . . . Niels Reimers, our director, was agreeable to Calgene having the benefit of the 1984 offer since we have not yet announced our new terms."; "no attachments

    Letter dated March 15, 1985 from Katharine Ku to Ed Pandolfino, Becton Dickinson Immunocytometry Systems, "Stan Cohen FYI - K2" handwritten in upper right, also "file" handwritten by SNC; "Re: Stanford Docket S74-043, "DNA Cloning", "Enclosed for your files is a fully executed copy of the License Agreement covering the Cohen-Boyer patents."; no attachments

    Confidential memo dated March 14, 1985 from Kathy Ku "To: Stanford Docket File S74-043, "DNA Cloning", "SUBJECT: Meeting with Cetus on March 5, 1985" re termination of the Cohen/Boyer license

    Letter dated March 14, 1985 from Katharine Ku to Albert P. Halluin, Cetus Corporation "to confirm our understanding of Cetus's reasons for terminating the License Agreement"

    Letter dated February 13, 1985 from Katharine Ku to R. G. Schweikhardt, ZymoGenetics "Re: Stanford Docket S74-043, "DNA Cloning", "delighted to have ZymoGenetics as a licensee"

    Letter dated February 14, 1985 from Katharine Ku to Richard W. Armentrout, Syntro Corporation "Re: Stanford Docket S74-043, "DNA Cloning", "delighted to have Syntro as a licensee"

    Letter dated February 13, 1985 from Katharine Ku to M. James Barrett, Life Technologies, Inc. handwritten note in upper right, "2/13 Stan - If you helped in any way, thank you! Kathy"; "Re: Stanford Docket S74-043, "DNA Cloning", "very pleased to have Life Technologies as a licensee"

    Letter dated January 31, 1985 from Katharine Ku to Nanette Newell, Calgene "Re: Stanford Docket S74-043, "DNA Cloning", "delighted to have Calgene as a licensee"

    Letter dated January 18, 1985 from Katharine Ku to John Chester, National Science Foundation "Re: Stanford Docket S74-043, "DNA Cloning", request for SNC grant proposals prior to November 4, 1974, "In particular, we would like any research information" for Grant GB30581

    Letter dated January 7, 1985 from Katharine Ku to Roger Ditzel, Patent, Trademark & Copyright Office, University of California, cc H. Boyer and SNC; "Re: Stanford Docket S74-043, "DNA Cloning", letter provides "brief summary of the licensing status"

    Letter dated January 3, 1985 from Katharine Ku to Donald Perella, Merck & Co., Inc. "Re: Stanford Docket S74-043, "DNA Cloning", returning fully executed copy of licensing agreement; no attachment.

    9517 Cohen/Boyer patent information, 1986
    Letter dated February 1, 1988 from Katharine Ku to Sarah S. Friel, Centocor, at top right "Dr. Stan Cohen" handwritten; "file" handwritten by SNC; "Re: Stanford Docket S74-043, "DNA Cloning"; "Enclosed is a fully executed copy of the Agreement for your records. We are delighted Centocor is a Cohen-Boyer licensee. "; agreement is not attached to this letter, though photocopy shows paperclip

    Letter dated January 29, 1988 from Katharine Ku to Steve Peltzman, Applied BioTechnology Inc., at top right "Stan Cohen FYI P.S. Austgen-Biojet terminated" handwritten, "file" written by SNC; "Re: Stanford Docket S74-043, "DNA Cloning", "We are delighted Applied BioTechnology will become a Cohen-Boyer licensee. Enclosed are two execution copies of the License Agreement for your signature.", agreement is not attached to this letter, though photocopy shows paperclip; stapled behind is another letter dated January 29, 1988 from Katharine Ku to Sarah S. Friel, Centocor, "Re: Stanford Docket S74-043, "DNA Cloning"; ". . . You indicated that you had the duplicate originals of the Agreement for signature; if you have any questions, please call me. Otherwise we will be expecting the executed Agreement and payment any day."; agreement is not attached to this letter, though photocopy shows paperclip

    Letter dated December 11, 1986 from Katharine Ku to S. Guttmann and C.S. Morris of Sandoz AG in Switzerland, "Re: Stanford Docket S74-043, "DNA Cloning", "For companies who signed after July 1986 but before we changed the royalty terms, we were offering a Five-Thousand Dollar ($5,000) license issue fee. We inadvertently failed to offer Sandoz the same terms and thus Sandoz paid $10,000"

    Form letter template from Katharine Ku with handwritten date "12/11/86" and handwritten "Dr. Stanley Cohen FYI--Kathy" in upper right; letter text about DNA probes, "We have been asked by one of our licensees to clarify the meaning of "intact gene" and "foreign gene" as used in the patents under the subject license and, in particular, with respect to DNA probes. . . . . please be advised that DNA probes are considered to be Licensed Products and their associated royalty obligations are payable."

    One page spreadsheet "Annual Royalties" for Docket No: S74-043, Fiscal year: 1985-86; Gross Income $1,255,145.98 - Admin. Fee $188,271.90 - Current Expenses (Fiscal Year) $63,308.93; Net Income $1,003,565.15 divided 50/50 with UC; "Net Income to Stanford 501,782.57", divided 1/3 to SNC $167,260.86 + 1/3 to SNC's two departments (1/6 to Genetics $83,630.43, 1/6 to Medicine $83,630.43) + 1/3 to School of Medicine $167,260.86; stapled behind spreadsheet is small paper with OTL letterhead, a note dated November 21, 1986 from Sally Hines to SNC, "Per your secretary's request, attached are copies of the reports we send to UC each year on the DNA Cloning patents. These reports reflect all income and expenses." Behind note are stapled five one-page spreadsheets with Report for Distribution of License Revenue for Stanford Fiscal Year (September 1 - August 31) 1985-86 ("SH" in lower right); 1984-85 "Total License Revenues $857,190.82" ("F. Grolle" in lower right); 1983-84 "License Revenues $700,645.10" ("S. Hines" in lower right); 1982-83 "License Revenues $686,720.88" ("FG" in lower right); and "Report Through August 3, 1982", "Income $1,447,000" (no name attached to this spreadsheet)

    Letter dated November 4, 1986 from Katharine Ku to C.S. Morris, Sandoz AG, at top right handwritten "bcc: Stan Cohen FYI--Kathy"; "Re: Stanford Docket S74-043, "DNA Cloning"; "We are pleased that Sandoz has decided to become a licensee of the Cohen-Boyer patents. Enclosed for execution are two signed copies of the License Agreement"; agreement is not attached to this letter

    Clipping of article "Technology Licensing staff takes ideas to market," by Julia Sommer, Campus Report, June 11, 1986, p. 19. Paragraphs 15-20 about Cohen/Boyer patents, beginning: "Probably the most publicized technology licensing endeavor is OTL's genetics engineering licensing program, which is based on two patents and a patent application covering gene cloning techniques, and the recombinant molecules produced through these techniques, developed by Stanley Cohen of Stanford and Herbert Boyer of UC-San Francisco."

    Letter dated October 17, 1986 from Katharine Ku to Scott G. Hallquist, Immunex Corp., at top right handwritten "Stan Cohen" and in SNC's handwriting "file"; "Re: Stanford Docket S74-043, "DNA Cloning"; text: "We are pleased that Immunex has decided to take the Cohen-Boyer license. . . . although Stanford has announced a change in royalty rates for new licensees, we are willing to license Immunex under the terms we had discussed previously."

    24-page "Tissue Plasminogen Activator" report by Floyd Grolle, OTL, August 1986; upper right of cover page "Cohen/Boyer patent file" handwritten by SNC

    Article "Licensing Program for Basic Gene Splicing Techniques, ACS Honors Cooperative UC-Stanford Biotechnology Licensing Program," While you were in, Vol. 4, p. 2, August 1986 (newsletter is "News for the Office of the President, University of California"); handwritten note "9/26/86 Stan Cohen FYI--Kathy"; American Chemical Society award to Stanford OTL and UC Office of Technology Transfer for "insightful and enlightened cooperative licensing of the Boyer/Cohen U.S. Patent No. 4,237,224"

    Memo dated September 22, 1986 from Niels Reimers to Robert Street, Pat Devaney, Jim Rosse, Donald Kennedy, Kent Peterson, Bill Massy, David Korn, and Stanley Cohen, handwritten by SNC in upper right of memo is "File Cohen/Boyer patent"; re ACS award; "It was given following a "Symposium on Innovation to Regain the U.S. Competitive Edge." The attached paper, given during the symposium, may be of interest."; clipped to memo is "Licensing of Recombinant DNA Technology" by Niels Reimers

    Memo dated September 15, 1986 from K. Ku to Don Dunner, Bert Rowland, Adrian Arima, and Aldo Test, "Subject: DNA Cloning"; upper right of memo has handwritten "Stan--FYI--Kathy" and "Cohen/Boyer patent file" handwritten by SNC; memo text includes "Enclosed is a draft letter for your review and comment. With respect to "foreign gene" and "DNA probes," we present three alternative positions we could publicly announce; we could, of course, not address those issues until it becomes necessary", also asks for comments on "announced changes to the earned royalty terms, effective October 1. There will be a flat 1% earned royalty on End Products and a flat 3% on Bulk Products (compared to the previous decreasing royalties based on sales volume)."; attached to memo is template of form letter with three alternative positions re "foreign gene" and "DNA probes"; Alt. 1 and Alt. 2 start "While to us it is clear that techniques of the patents are used to make DNA segments used for probes, we recognize that the patent wording could be more precised with respect to such coverage; but recall the term "DNA probe" was not available in 1974 when the patent was filed."; Alt. 1 continues, "Hence, please be advised that, pending action by the Patent Office on No. 602,294, royalty payments for DNA probes may be put into escrow."; Alt. 2 continues, "Hence, please be advised that no royalty payment for DNA probes will be required until the Patent Office has rendered a decision."; Alt. 3: "It is clear that techniques of the patents are used to make DNA segments used for probes. Hence, please be advised that DNA probes are considered to be Licensed Products and their associated royalty obligations are payable."

    Memo dated September 2, 1986 from Niels Reimers to Jasper Williams, cc S. N. Cohen, W. F. Massy; upper right of memo has "file" handwritten by SNC; text discusses "Agreement wherein the University agrees to amend Stan Cohen's royalty-sharing Agreement insofar as his binding pledge to make an annual gift to a charitable organization. I should note that Stan has indicated that he still plans to make an annual gift of his share of royalties to a charitable organization, but does not wish to be bound to do so.", NR has drafted agreement for signature by Bill Massy, "I want to be sure that David Korn, Bill Massy, Bob Street, and Don Kennedy know about this before it is executed and have the opportunity to comment.", would let public know "in a low key way, perhaps as an additional paragraph to another news release. I'll be discussing the form of that with Spyros and Stan."; no attachment

    Two-page memo dated September 12, 1986 from Niels Reimers to SNC, "SUBJECT: "Agreement dated June 19, 1975, Concerning Rights in Invention between Stanley N. Cohen and Stanford University (Stanford Docket S74-043)"; "That agreement was amended December 28, 1982, with respect to payment of the inventor's share of royalty income. Pursuant to your request, this memorandum will further amend the subject agreement insofar as your binding pledge to make an annual gift to a charitable organization"; memo signed by NR at bottom like a letter, below which "AGREED AND ACCEPTED" signature lines for "THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY" (unsigned) and SNC (signed September 21, 1986)

    Undated draft of Niels Reimer article "Licensing of Recombinant DNA Technology"; upper right of first page has "file" handwritten by SNC; final version of paper given during 1986 "Symposium on Innovation to Regain the U.S. Competitive Edge";

    Memo dated July 31, 1986 from Niels Reimers to SNC, "SUBJECT: Change to Royalty-Sharing Agreement"; "Attached is my draft of an Amendment to the Royalty Distribution agreement between yourself and Stanford that changes your "binding pledge" to make an annual gift of your royalty distribution to a charitable organization."; memo says copies of original Agreement and first Amendment attached, but they are not attached to this copy of memo; NR asks SNC to review draft and "I will want to have it reviewed by staff legal counsel, and I will review its subject matter with Drs. Korn, Kennedy and Street"; upper right of first page has "file - Cohen/Boyer patent" handwritten by SNC; attached three-page draft Agreement

    Two-page memo dated August 18, 1986 from Niels Reimers to SNC; "Pursuant to your request, this letter will further amend the subject agreement insofar as your binding pledge to make an annual gift to a charitable organization."; post-it attached to front dated 8/18/86 "Please call Niels Reimers after reading this at 723-0651 and let him know if any changes need to be made."; "OK" at bottom of post-it handwritten by SNC

    Letter dated August 14, 1986 from Katharine Ku to Claire Wake, Damon Biotech, Inc., "Re: Stanford Docket S74-043, "DNA Cloning"; "I consider the enclosed fully executed Agreement to be one of my (and your) major accomplishments this year!"; agreement is not attached to this letter; at top right handwritten "Dr. Stan Cohen" and "Cohen/Boyer patent file" handwritten by SNC; at bottom of letter "8/14 Stan: Damon & Microgenics are recent new licensees. We now have 79. K"; stapled to letter is two-page list "Cohen-Boyer Licensees . . . . as of 8-11-86" listing 79 licensees

    Letter dated July 30, 1986 from Katharine Ku to Steven M. Odre, AmGen, "Re: Stanford Docket S74-043, "DNA Cloning"; " re "Assignment of the Cohen/Boyer DNA Cloning License by BioLogicals to AmGen"

    Memo dated March 28, 1986 from SNC to David Korn, "SUBJECT: Royalties from the Cohen/Boyer Patent" thanks for update re 4 Postdoctoral Fellows supported by Bernard Cohen Postdoctoral Fellowship Fund; OTL estimates Cohen/Boyer patent royalties to Stanford and UC from 1986-1997 will total $106 million; "There are several issues regarding the Cohen/Boyer patent royalties and royalty distributions that I believe are worthwhile discussing with you if the financial return to the School of Medicine is to be maximized. Please let me know if and when you would like to have such a discussion."; attached "PRELIMINARY ESTIMATES OF COHEN-BOYER PRODUCT SALES 1986-1997" prepared by Floyd Grolle of OTL March 26, 1986, marked "CONFIDENTIAL"

    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 4/29/86, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; cover sheet identical to that on seven documents cataloged in Rows 50-54, 65-66 of this spreadsheet, except that newest entry on this table is "Fee sheet/ Third Pre. Amend.", Official Date 4/25/86, Forwarded to Client 4/29/86; attached Transmittal Sheet dated April 25, 1986 and signed by Bertram I. Rowland, and three-page "THIRD PRELIMINARY AMENDMENT" adding new Claims 69-77, signed by Bertram I. Rowland on April 25, 1986

    Letter dated March 28, 1986 from Michael F. Borun, Marshall O'Toole, et al. on behalf of Amgen to Katherine [sic] Ku; "For Dr. Stanley Cohen" handwritten in upper right, also "file" handwritten by SNC; enclosed $10,000 check "representing 1986 payment by Amgen as assignee of Bio Logicals, Inc."; copy of check not attached

    Memo identical to one catalogued in Row 87 of this spreadsheet; no attachment

    Letter dated February 18, 1986 from Charles E. Lipsey of Finnegan, Henderson, Farabow, Garrett & Dunner in Washington, DC to Katharine Ku; "Enclosed is a draft second Preliminary Amendment for your review.", "Error p.24" handwritten by SNC near bottom of letter; handwritten note from Katharine Ku clipped to letter, "2/25/86 Stan: Please review this as a contrast to Bert's version. . . ." attached SECOND PRELIMINARY AGREEMENT" cancels Claims 40-44 and adds Claims 45-62.

    Letter dated February 18, 1986 from SNC to Bertram Rowland; "When we last met I mentioned to you a 1962 paper by W. Szybalski and E. H. Szybalska in which authors reported a system for accomplishing DNA-mediated heritable transformation of a biochemical trait into mammalian cells. You indicated that this information would be of use to you in extending the scope of the Cohen/Boyer patent(s)."; gives bibliographic info: PNAS, Vol. 48: 2026-2034.

    Two-page letter dated January 6, 1986 from Bertram I. Rowland to SNC; "The following are some of my thoughts that I would like to discuss with you when we meet on Tuesday afternoon.", next six paragraphs detail his thoughts and questions; first page of letter has handwritten notes by SNC

    Letter dated January 28, 1986 from Katharine Ku to John Demeter, Rohm & Haas Company; "Stan Cohen" handwritten in upper right, also "file" handwritten by SNC; "Enclosed is a fully executed copy of the DNA Cloning License Agreement for your records. You will be happy to know that the payment for this year is only $10,000, not $20,000, since your license issue fee will serve as the 1986 annual minimum royalty."

    9518 Cohen/Boyer patent information, undated
    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 12/21/87, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; also attached documents: Conditional Petition for Extension of Time, signed by Bertram I. Rowland on 12/21/87 and nine-page Supplemental Amendment submitted to Patent Examiner A. Tanenholtz, signed by Bertram I. Rowland on 12/21/87

    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 12/31/87, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; cover sheet identical to one of documents immediately preceding it in file, except for new line added to table on cover sheet: "Fee Sheet/Supplemental Amendment, official date 1/4/88, forwarded to client 12/31/87; attached nine-page Supplemental Amendment has several changes from 12/21/87 version and is signed by Bertram I. Rowland on 12/30/87

    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 12/15/87, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; cover sheet identical to that on two documents immediately preceding it in file, except that newest entry on table is "Response/Declartion [sic] under 37 CFR 1.132", official date 12/15/87, forwarded to client 12/15/87; attached two-page Supplemental Amendment signed by Bertram I. Rowland on 12/15/87

    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 8/13/87, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; cover sheet identical to that on three documents immediately preceding it in file, except that newest entry on table is "Supplemental Response/Declaration under 37 CFR 1.132, no official date or forwarded to client date entered on sheet; attached Conditional Petition for Extension of Time, signed by Bertram I. Rowland on 9/4/87, five-page Supplemental Amendment submitted to Patent Examiner A. Tanenholtz, signed by Donald R. Helinski on 8/18/87, and 13-page Donald R. Helinski CV

    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 7/22/87, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; cover sheet identical to that on four documents immediately preceding it in file, except that newest entry on table is "Response", official date 7/17/87, forwarded to client 7/22/87; attached Conditional Petition for Extension of Time, letter to the Commissioner of Patents and Trademarks, and six-page Response all signed by Richard L. Neeley on 7/17/87; four-page Delcaration [sic] Under Rule 132 signed by Ronald W. Davis on 6/1/87; 13-page Ronald W. Davis CV; and one-page Supplemental Letter to the Commissioner of Patents and Trademarks, signed by Richard L. Neeley on 7/17/87 stating that "Various publications are being provided to the Examiner . . . . Other promised publications will be submitted as they become available."; photocopies of seven academic articles are attached, including SNC's Cohen et al., 1973 and Cohen et al., 1972

    Butterfly clamp holding: printout of presentation by Floyd Grolle at OTL retreat in August 1993, "We wanted the OTL staff to realize the impact that these royalties make on Stanford's operations."; various articles from 1975-87 about Cohen-Boyer patent; 1989 and 1993 lists of licensees; and spreadsheet with 1990 revenue and projections of revenue 1991-97

    Note from OTL dated 7/14/87, "Attached are copies of the response and delcaration [sic] for S74-043; unsigned copies of "Delcaration [sic] Under Rule 132" with signature line for Ronald W. Davis and "Response" with signature line for Bertram I. Rowland

    Letter dated March 9, 1987 from Yoshi Kumagai of KIRIN USA, INC. to Sandra L. Shotwell of OTL, handwritten "cc S. Cohen"; handwritten notes in margin "S78-083", "S80-023", "Hollow fiber"; "I have forwarded the information to the headquarters of KIRIN in Tokyo and our staff is reviewing them carefully."

    Letter dated March 7, 1989 from Katharine Ku to James R. McBride, Becton Dickinson and Co., cc N. Mhatre, handwritten at top right "S. Cohen", "Re: Stanford Docket S74-043, "DNA Cloning"; text ". . . enclosed are two signed copies of the License Agreement covering the Cohen-Boyer patents."

    9519 Cohen/Boyer patent information, undated
    Photocopy of Wensink et al., 1974, "A System for Mapping DNA Sequences in the Chromosomes of Drosophila melanogaster" Cell, 3:315.; references include Cohen et al., 1973 and Morrow et al., 1974

    Photocopy of Mertz and Davis, 1972, "Cleavage of DNA by R1 Restriction Endonuclease Generates Cohesive Ends", PNAS, 69:3370.

    Hershfield et al., 1974, "Plasmid ColE1 as a Molecular Vehicle for Cloning and Amplification of DNA", PNAS, 71:3455.; "We thank Dr. Stanley Cohen for plasmid pSC105 and for helpful suggestions."; references include Cohen et al., PNAS, 1972; Cohen and Chang, 1973; Cohen et al., 1973; and Morrow et al., 1974

    One page of handwritten notes dated 3/4/87, has initials "KK" in upper left and "FG" in lower right, about licensee Amgen; list of products, "We want to keep an eye on them--will they report any sales?"

    Letter dated February 2, 1987 from Paul T. Clark of Fish & Richardson to Katharine Ku; "Bob Carpenter of Integrated Genetics, Inc. has referred your letter to him of December 11, 1986 to us. . . . In the case of probes, we have advised our client that the Stanford patents cannot be stretched to cover their probes, and therefore no royalties on probes are due."

    Letter dated April 25, 1985 from Katharine Ku to SNC; request to review attached declarations, "In addition, are you aware of any patent, printed publication, or public use which is more pertinent to the Boyer/Cohen invention than the Lobban thesis or the Mertz and Davis article, PNAS 69:3370-3374 (November 1972)?"; "Lastly, please provide the dates on which the experiments set forth in the laboratory notebook pages appended to the Cohen/Boyer Rule 132 declaration were conducted."; 10 attachments to letter: 1) memo dated April 25, 1985 from Niels Reimers to "Professors S. Cohen, R. Schimke, R. Davis, G. Ringold, L. Kedes, and J. Leavitt", cc to Adrian Arima, David Korn, Jerry Lieberman re "Licensing Proposal for Biotechnology "Tool" Patents", "most of you are aware I proposed, along with Roger Ditzel of UC, that universities pool all of their biotechnology tool patents for licensing to industry. . . The proposal made by Roger and me was not greeted with great enthusiasm by most industry or other universities. . . . Our plan is to group the biotechnology tools we now have in a single license", memo includes enclosures "Draft blanket license" and "Alternative royalty schedule for individual patent licensees"; 2) "Declaration Under Rule 131", unsigned with signature lines for SNC and Boyer; 3) five photocopied pages of lab notebook (SNC says it looks like Annie Chang's writing); 4) "Declaration of Stanley N. Cohen", re plasmid pSC101 signed by SNC on February 1, 1984; 5) "DECLARATION UNDER RULE 132" signed by SNC on October 28, 1982; 6) article by S.N. Cohen and A.C.Y. Chang, J. Bac., 1977; 7) article by S. Chang and S.N. Cohen, PNAS, 1977; 8) article by S.N. Cohen et al., PNAS, 1973; 9) letter dated September 5, 1974 from SNC to Dick Roblin, Mass. General listing 32 people who have requested and received the pSC101 plasmid; and 10) unsigned two-page letter dated September 6, 1977 from SNC to Donald Fredrickson, Director, NIH enclosing a manuscript [not included in this file] in press with PNAS, "I have taken the unusual step of sending it to you prior to publication because I believe the findings have policy, as well as scientific, importance with regard to the regulation of recombinant DNA", " . . . along with virtually all of the other scientists who first raised these questions, I have since come to believe that our initial concerns were greatly overstated." (this letter also catalogued in Rows 286 and 328)

    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 1/23/87, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; cover sheet identical to that on six documents cataloged in Rows 50-54, 66 of this spreadsheet, except that newest entry on this table is "Office Action", official date 1/20/87, forwarded to client 1/23/87; post-it attached to cover sheet with handwritten note: "1/26/87 Stan - We finally got an Office Action & will be deciding how to proceed in next month or so - Kathy"; attached Office Action form from USPTO to Bertram I. Rowland, response due April 20, 1987, "Claims 45-77 are rejected", stapled to form is five-page text by Primary Examiner Alvin E. Tanenholtz explaining rejection, this text has numerous handwritten comments by SNC addressing the science and conclusions, such as "Not true, BPU replicates on plasmid--same mechanism", "B.S.--what evidence?", and "ignorant comment"; also attached are two pages of Form PTO-892, "Notice of References Cited", both filled out by hand and signed "Tanenholtz 1/8/87"

    Legal documents from and patent documents prepared by Leydig, Voit & Mayer: log sheet "Attention: Kathy Ku" covering period 4-25-84 to 4/18/86, listing papers pertaining to "Process and Composition for Biologically functional molecular chimera", Stanford Docket S74-043, for client Stanford; cover sheet identical to that on seven documents cataloged in Rows 50-54,65 of this spreadsheet, except that newest entry on this table is "Preliminary Amendment w/ enclosures", official date 4/17/86, forwarded to client 4/18/86; attached are 29-page "Second Preliminary Amendment" signed by Bertram I. Rowland on 4/17/86; and five-page "Appendix 1 Claim Comparison" comparing "Serial No. 602,294 Claim 45" to "Patent No. 4,237,224 Claim 1"

    Six-page Declaration signed by SNC on April 20, 1983 re contributions of Robert B. Helling "to the invention disclosed and claimed in application SN520,691", attached to Declaration are three SNC articles: "The Stanford DNA cloning patent", 1982; "The Transplantation and Manipulations of genes in Microorganisms: Harvey Lecture", 1979; and "The Manipulation of Genes", 1975.

    9520 Cohen/Boyer patent information, 1988-1991
    Paperclip holding: 1) Small heavystock paper with undated handwritten note from "Susan" to SNC thanking SNC for speaking at Bert Rowland's memorial, mentions "He was always extrememly proud of what he considered his greatest professional accomplishment: writing the Cohen-Boyer patents.", also says that memorial was videotaped; 2) Three-page printout SNC's talk, "Bert Rowland Memorial comments. Stan Cohen" dated 11/26/10, talk has "File" handwritten by SNC at top right of p. 1 and all three pages have edits handwritten by SNC; and 3) in between pp. 2-3 of the talk is a printout of the program, "In Loving Memory of Bert June 26, 1930 - October 28, 2010"

    Printout dated 5/21/98 of article "Stanford DNA 'enforcer' Grolle closes the $200M book on Cohen-Boyer", Joan O'C. Hamilton, Signals, published 11/25/97; five pages; business card of Katharine Ku, Director of OTL stapled to top right of first page, with handwritten "To Stan Cohen"; small yellow post-it attached to first page, "File--Cohen/Boyer patent" written by SNC

    Spreadsheet titled, "COHEN-BOYER ROYALTIES DISTRIBUTION. . ..1980 THRU 1996-7"; business card of Katharine Ku, Director of OTL stapled to top left of page with handwritten "Prof Stan Cohen"; in upper right of page stamp "RECEIVED SEP 2? 1997" {perhaps SEP 22} and "Cohen/Boyer patent file" written by SNC; lower right of printout "9/15/97 "F. Grolle" "

    Fax of article, "Tiger by the tail" by Niels Reimers, Journal of the Association of University Technology Managers, Vol. 5, 1995, pp. 25-47; reprinted from CHEMTECH, August 1987, 17(8), pp. 464-471; sent 11/29/95 from Stanford Tech. Lic.

    "Stanford Technology Brainstorm, the Newsletter of Stanford University's Office of Technology Licensing (OTL)", Vol. 5, No. 2, Autumn 1996; stamped RECEIVED DEC 1? 1996 {perhaps DEC 17} in upper right; "Cohen/Boyer patent file" written by SNC in upper right; "IN THIS ISSUE . . . Cohen-Boyer Still a Strong Part of OTL's Licensing Activity"

    Letter dated August 6, 1996 from SNC to Eugene Bauer, Dean of Stanford School of Medicine, re "proposal to establish a new School of Medicine academic program of lasting value, using funds provided by the Cohen/Boyer patent income"

    Letter dated January 31, 1996 from Condoleezza Rice, Provost of Stanford University to SNC; response to January 23, 1996 memo from SNC to CR, cc to President Gerhard Casper and Dean Eugene Bauer re "Cohen/Boyer Patent Income"

    Letter dated July 31, 1996, from David J. Aston, Associate Director, UC Office of Technology Transfer to Katharine Ku, Director of Stanford University Office of Technology Licensing, cc Terence A. Feuerborn, Executive Director UCOTT and Niels Reimers, Director, Office of Technology Management, UCSF, re "We do not believe that it would be appropriate to pursue a patent term extension by way of a private bill in the United States Congress."; handwritten in upper right "Stan Cohen FYI -- K2"

    Four-page memo dated June 10, 1996, from Floyd Grolle, Office of Technology Licensing to SNC, stamped "RECEIVED JUN 13 1996" re "Cohen-Boyer Status Report" on royalties; "file" written in upper right by SNC

    Robertson Stephens & Company Institutional Research Biotechnology Calendar, August-September 1995, dated August 1, 1995, "Cohen/Boyer patent file" handwritten by SNC in upper right of first page, 20 pages; clipped behind it is complimentary issue of BioWorld Financial Watch, Vol. 3, No. 42, containing article, "The Promise of Gene Therapy Still Lures Big Investors" by Jennifer Van Brunt, cover page and p. 13

    Undated three-page article without a byline "Products in the U.S. Pipeline from the Pharmaceutical Manufacturers Association"; handwritten by SNC in upper right "file with material from Lampert"

    One page of fax from Stanford Tech. Lic. sent September 29, 1995, labeled P.4 re status of Docket S 74-043, title, "Cohen/Boyer; Recombinant Technology" it is part of 13-page fax photographed in IMG_0062.jpg

    Printout of United States Patent 4,237,224, "Process for Producing Biologically Functional Molecular Chimeras", Inventors: Cohen and Boyer, December 2, 1990

    Fax from Stanford Tech. Lic. sent September 29, 1995 re status of Cohen intellectual property managed by OTL; 12 numbered pages stapled in random order; page 10 re Docket S78-077, "Protein Production At Synthetic Start Site", inventors Nunberg, Chang, Cohen and Schimke; pages 3,6,5,7,8,and 9 re Docket S74-043, title, "Cohen/Boyer; Recombinant Technology"; page 11 re Docket S92-106, "Use of tRNA Genes to Stabilize the Inheritance of Unstable Plasmids in Populations of Growing Cells", inventors Vogtli and Cohen; page 12 re Docket S93-160, "Method for Concurrent Disruption of Expression of Multiple Alleles of Eukaryotic Genes", inventors Li and Cohen; page 13 re Docket S93-161, "docket created to classify all of Cohen's many (over 70) IRPs on file with OTL"; page 1 cover sheet, from "Christina -- OTL" to "Stanley Cohen's Office" page 2 re Docket S73-061 "MEDIPHOR/MINERVA/MUMPS (Software)", inventor S. Cohen; page 4 is missing and is filed alone (photographed in IMG_0060.jpg)

    Letter dated September 27, 1994 from SNC to Arian Arima, General Counsel's Office, Stanford University; small sheet with fax transmission report and two-page letter responding to September 23 memo (IMG_0064.jpg) re payment for invention incorrectly characterized as "royalty" when it is "an installment sale"

    Memo dated September 23, 1994, from Adrian Arima, General Counsel's Office to SNC, cc Chris Canellos and Iris Brest, Controller's Office and Kathy Ku, OTL, "Subject: Payments on Patent" re "your request to characterize the payments on your invention as "installment payments for technology" rather than "royalties" as described in letter from Maggie Feinstein; two pages, not attached to each other

    Letter dated January 10, 1994 from SNC to Floyd Grolle, OTL re funds paid to SNC in connection with Cohen-Boyer patent "The records of the University should indicate that the funds are given as payment for technology, instead of being termed "patent royalties" "

    Memo dated September 13, 1994 from Maggie Feinstein, OTL Accountant to SNC, cc Floyd Grolle and Kathy Ku, "File Boyer/Cohen patent" written by SNC in upper right, re "FY 93-94 Installment Payment for Cohen-Boyer Technology"; text: per Chris Canellos a letter from SNC needed to ensure SNC's 1993-1994 "check reflects that it is an "Installment Payment for Technology" rather than a payment for "patent royalties.";

    Letter dated April 12, 1994 from William T. Davis, Associate Director of University of California Office of Technology Transfer to Katharine Ku, Director of Stanford University Office of Technology Licensing, handwritten "To Stan Cohen" in upper right and in SNC's handwriting, "File"; text re "clear consensus that the University of California will not endorse or participate in any effort to extend the DNA Cloning patents"

    Letter dated February 11, 1993 from Katharine Ku, Director of Stanford University Office of Technology Licensing to William Davis, Associate Director of University of California Office of Technology Transfer, cc to SNC, David Korn, and Larry Horton,stamped in upper right RECEIVED FEB 15 1993; "file" written by SNC in upper right; text re info provided to Stanford by Bertram Rowland, "Bert believes that the University of California would need to endorse and participant [sic] in any effort to extend the DNA Cloning patents"

    Printout of United States Patent 4.468,464, "Biologically Functional Molecular Chimeras", Inventors: Cohen and Boyer, August 28, 1984

    Memo dated November 15, 1993 from Kathy Ku to Dean David Korn, cc Peter Van Etten, Larry Horton, Stan Cohen, Floyd Grolle re Extension on Cohen/Boyer patents; stapled to memo is a two-page letter dated November 9, 1993 from Bertram I. Rowland to Katherine [sic] Ku re "Private Relief Bill to Patent Extension," Stanford reference S74-043 which begins, "I am enclosing a memorandum prepared by Bred Field describing his investigation of opportunities to obtain patent extensions"; attached to letter are a memo and a bill: five-page memo dated October 22, 1993 from Bret Field to Bert Rowland re "Private Relief Bill to Extend the Term a Patent [sic]" and the four-page text of a bill, "AS REFERRED IN THE SENATE H.R. 5475", Version 4 of "AN ACT Providing policies with respect to approval of bills providing for patent term extensions, and to extend certain patents" passed by the House of Representatives on August 4, 1992

    Listing of Cohen-Boyer Licensees 10/12/92; 195 licensee companies

    Two-page memo dated January 27, 1992, from Donald Kennedy, Stanford President to SNC, stamped "RECEIVED FEB-4 1992"; refers to recent conversation: "I was glad of the opportunity to talk with you about royalty matters." concludes "we should not return to the royalty arrangement described in your 1975 contract as you interpret it", recaps Stanford's royalty policy in 1975 and DK/SNC royalty discussion in 1979 or 1980 which led to new policy described in attached memo (three pages) dated April 17, 1980 from Niels Reimers to SNC, cc to Adrian Arima, Donald Kennedy, Gerald Lieberman, William Massy and Kent Peterson

    Memo dated October 25, 1991 from David Korn, Vice President and Dean to SNC, "Patent file" handwritten by SNC in upper right corner, "Subject: Patent Royalties", responding to SNC memo of October 23; "the 15% tax generates funds well in excess of OTL expenses, but it was Bob Byer's [Dean of Research/Vice Provost Robert L. Byer] and Jim Rosse's [James Rosse, Provost] decision to use the overage as a research innovation seed fund under the authority of the Dean of Research . . . I would suggest that you bring your concern directly to the Provost's attention, perhaps copying me on any written communication, and see whether you can make more progress than I did."

    Fax cover sheet dated October 4, 1991 from Mark Lampert to SNC "Attached is the letter which we sent to Stanford." and two-page letter dated September 6, 1991 from Greg Sabouri [no letterhead, no job title listed] to Jon Sandelin, Acting Director, Office of Technology Licensing; proposal that "(1) Oppenheimer will acquire from a 30% to an 80% interest in Stanford's portion of the Cohen-Boyer royalties. (2) The price will be based on a $70 million valuation of the entire royalty stream."

    Two-page memo dated November 22, 1991 from Katharine Ku to SNC, cc R. Byer, P. Devaney, P. Van Etten, A. Arima; "Re: 15% OTL allocation"; "In response to your request that we interpret the royalty-sharing agreement as signed by you and Stanford in June, 1975 with respect to the OTL 15% deduction, I have conferred with the Dean of Research's office and the Legal Office. . . . It is our unanimous opinion that the fifteen percent allocation for OTL is a flat 15%, rather than a changing percentage up to 15%."; this document is immediately followed in the files by another copy of the same document (IMG_0083.jpg), identical except that on the first one the OTL letterhead and fax stamp are not visible at the top of each page

    Memo dated November 22, 1991, faxed from STANFORD TECH. LIC. on November 22, 1991, from Katharine Ku to SNC, cc R. Byer, P. Devaney, P. Van Etten, A. Arima; "Re: 15% OTL allocation"; "In response to your request that we interpret the royalty-sharing agreement as signed by you and Stanford in June, 1975 with respect to the OTL 15% deduction, I have conferred with the Dean of Research's office and the Legal Office. . . . It is our unanimous opinion that the fifteen percent allocation for OTL is a flat 15%, rather than a changing percentage up to 15%."; two pages; this document is immediately preceded in the files by another copy of the same document (IMG_0082.jpg), identical except that on the first one the OTL letterhead and fax stamp are not visible at the top of each page

    Spreadsheet with handwritten "10-1-91 FG" at lower right; in upper right of page are handwritten "10-18-91 To Stan Cohen: FYI from K Ku" and date stamp "OCT 23 1991"; contains two charts: "COHEN-BOYER ROYALTIES . . . ACTUAL & ESTIMATED" covering 1987-1991, and "LISTED BELOW ARE THE ESTIMATED COHEN-BOYER ROYALTIES FROM FISCAL 1991-92 THRU 1997-98"; this document is immediately followed in the files by another copy of the same document (IMG_0085.jpg), identical except that on the second one "Stan Cohen: FYI" is highlighted in yellow

    Spreadsheet with handwritten "10-1-91 FG" at lower right; in upper right of page are handwritten "10-18-91 To Stan Cohen: FYI from K Ku" and date stamp "OCT 23 1991"; contains two charts: "COHEN-BOYER ROYALTIES . . . ACTUAL & ESTIMATED" covering 1987-1991, and "LISTED BELOW ARE THE ESTIMATED COHEN-BOYER ROYALTIES FROM FISCAL 1991-92 THRU 1997-98"; this document is immediately preceded in the files by another copy of the same document (IMG_0084.jpg), identical except that on the second one "Stan Cohen: FYI" is highlighted in yellow

    Memo dated October 23, 1991, marked "Personal and Confidential", from SNC to David Korn, "Subject: Cohen/Boyer Patent Royalties: 15% deduction by the University"; "the fifteen percent deduction for the University is intended to be a "ceiling" sufficient to reimburse the University for its indirect costs, not an automatic deduction. . . . From my reading of the agreement, the funds being deducted by the University in excess of the true indirect costs of the OTL legitimately belong to the School of Medicine, the Departments of the Inventor (in the case of the Cohen/Boyer patent, Medicine and Genetics), and the Inventor."

    Letter dated July 5, 1989 from Katharine Ku to Serle Mosoff, General Counsel of Enzo Biochemical, cc to D. Dunner, "file" written by SNC in upper right and date stamped "JUL 10 1989"; "Re: Stanford Docket S74-043, "DNA Cloning", "Thank you for the signed License Agreement originals covering the Cohen-Boyer patents.", handwritten at bottom of page, "bcc: Stan Cohen: They were difficult to get "onboard" but they finally signed. Kathy";

    Memo dated January 13, 1989 from SNC to Sally Hines, OTL re Patent Royalties; request to assign rights to receive royalties from patents to "Stanley N. Cohen and Joanna L. Cohen Family Trust, Stanley N. Cohen, Trustee."

    Letter dated March 7, 1989 from Katharine Ku to Thomas D. Zindrick, The Dow Chemical Co., at top right "To Stan Cohen" handwritten and date stamp "MAR 10 1989"; "file" written by SNC, "Re: Stanford Docket S74-043, "DNA Cloning"; "We are delighted Dow has joined as a Cohen-Boyer licensee. Enclosed is a fully executed copy of the Agreement"; agreement is not attached to this letter, though photocopy shows paperclip

    Handwritten spreadsheet with "9-29-88 FG" written in lower right; stamped "CONFIDENTIAL"; "File Cohen/Boyer patent" written by SNC in upper right; "EXPECTED EARNED + MINIMUM ROYALTIES (FROM COHEN-BOYER LICENSE" columns for 1988-89, 1989-90, and 1990-91

    Printout of United States Patent 4,740,470, "Biologically Functional Molecular Chimeras", Inventors: Cohen and Boyer, April 26, 1988

    Letter dated October 6, 1988 from Katharine Ku to Joanne Thierstein, "Warner Lambert" [sic], at top right "Stan Cohen" handwritten, date stamped "OCT 11 1988", and "Cohen/Boyer patent file" written by SNC; "Re: Stanford Docket S74-043, "DNA Cloning"; "Enclosed is a fully executed License Agreement covering the DNA cloning technology. I am absolutely delighted your perseverance paid off and that Warner-Lambert is now a licensee of the Cohen-Boyer patents."; agreement is not attached to this letter, though photocopy shows paperclip

    Letter dated March 20, 1989 from Katharine Ku to Hiroshi Iwai, Takara Shuzo Co., Ltd., at top right "3/20 Stan Cohen FYI--Kathy" handwritten, date stamp "MAR 22 1989", and "Cohen/Boyer patent file" written by SNC; "Re: Stanford Docket S74-043, "DNA Cloning"; "We are delighted to have Takara Shuzo become a Cohen-Boyer licensee. Enclosed for your files is a fully executed License Agreement covering the DNA cloning technology."; agreement is not attached to this letter

    Handwritten note dated September 8, 1988 from Floyd Grolle to SNC, attached is "most recent "roster" of Cohen-Boyer licensees"; attached is two-page chart listing of 84 licensees "as of 9-1-88": columns are Licensee, Location, Credits, and Type

    Two-page chart dated September 1, 1988, "Cohen-Boyer Licensees (Current & Former)" listing 84 current and 14 former licensees: columns are Licensee License Date, and Cancel Date

    Photocopy of Science, August 19, 1988, p. 907, containing article "A Bit of Science History Is Lost" by Gregory Byrne about demise of The Waikiki Delicatessen, "the birthplace of modern biotechnology"; possibly sent to SNC by Floyd Grolle: "SCIENCE" handwritten in green ink at bottom of page and yellow post-it with "!!" in green ink are consistent with green ink and handwriting of Floyd Grolle on other documents in this collection

    "PMA Report: Biotechnology Products in the Pipeline" from Biotechnology, Vol. 6, September 1988, p. 1004 ff., 4 pages; stapled behind is a copy of Science article "A Bit of History Is Lost" (IMG_0100.jpg)

    Letter dated July 12, 1988 from Bertram I. Rowland to Kathy Ku, cc to "Inventor(s) with copy of patent; "I enclose the original and seven copies of the U.S. Letters Patent No. 4,740,470 which issued on April 26, 1988 . . . Please sign and return to me the enclosed copy of this letter to indicate receipt of this original Letters Patent", describes annuities due to keep patent in force and "Product made using the claims of the Patent can and should be marked with the patent number."; one copy of patent 4,740,470 attached

    Draft of Stanford News Bureau article, "Third Stanford-UC Genetic Engineering Patent Granted"; refers to patent granted April 26, 1988 [No. 4,740,470]; an edit by SNC has been mostly erased; business card of Katharine Ku stapled to front page with handwritten "Congratulations, Stan K" written on card

    Patent 4,740,470, "Biologically Functional molecular Chimeras" with Form PTO-194 stapled to front; form says "It will be accepted by the U.S. PATENT and TRADEMARK OFFICE in payment for copies"

    Memo dated March 24, 1988 from Floyd Grolle to SNC "Subject: Sales and Royalties Estimates"; "best estimates covering STANFORD FISCAL YEARS 1987-88, 1988-89, and 1989-90" and "March 26, 1986, PRELIMINARY ESTIMATES OF COHEN-BOYER PRODUCT SALES"; attachments as described; stapled document is 10 pages: one five-page original (CONFIDENTIAL stamped in red on memo and tables) and one photocopy

    Memo dated March 14, 1988 from Floyd Grolle to SNC "Below are our estimates of Cohen-Boyer royalties anticipated for the Stanford fiscal years of 1987-88, 1988-89, 1989-90, 1990-91 . . The final tabulations/payments for the 1987 calendar year are due April 1, 1988."

    9521 Oppenheimer & Co., Inc. 1991 Re: Cohen/Boyer Patent Royalties, 1991
    Letter dated September 19, 1991 from Mark N. Lampert to SNC; "You and I met last year to discuss my interest in purchasing a portion of the royalties derived from the Cohen-Boyer patents. . . . Obtaining a slice of the Cohen-Boyer royalty stream is absolutely critical to the success of our business.", asks to meet again; phone messages from Lampert to SNC dated September 27, 1991 and October 10, 1991 in Joanie Driscoll's handwriting

    Letter dated September 6, 1991 from Greg Sabouri to Jon Sandelin; stapled after letter is fax cover sheet.

    Workpapers - Patent Application 8140 Stanford/Cetus, 1976-19838141-44 Nunberg/Chang/Cohen, 1977-2003821-7 Nunberg/Chang/Cohen (cont'd), 1977-2003828-9 Michaels/Robertson/Cohen, 1979-19848210-11 Michaels/Robertson/Smith/Cohen, 1981-19848212-13 Michaels/Robertson/Taylor/Cohen, 1981-19848214-16 Cohen/Inloes/Matin, 1981-1984 Mediphor 8217 Sago/Mario/Negri, 1972-19768218 Stanford/B.D., 1974-19768219 Stanford/H.P., 1974-19758220 Stanford/B.W. agreement, 1980-19818221-23 Cohen/Inloes/Matin, 1985-1987 Articles 219 "Cohen-Boyer patent issued" Stanford Medicine, Winter 198537 Article about expiration of Cohen-Boyer patent - Stanford magazine, January/February 1998 Series 12: Travel, Meetings, and Seminars, 1976-20168224 Miles symposium, 19768225 COGENE meeting, Paris (first meeting), 19778226 Winthrop Laboratories, 19778227-28 National Academy of Sciences (NAS) DNA Forum - Washington, D.C., 7-9 March 19778229 Merck Institute trip - Rahway, NJ, 9 September 19778230 COGENE - Benefits and Applications of Recombinant DNA Technology - Key Biscayne, FL, June 19788231 Molecular Biology and Biotechnology Conference - Umea, Sweden, 24-26 September 19808232 Palo Alto Medical Research Foundation - Sun Valley, ID, 9-13 March 19818233 Burroughs Wellcome Fund meeting - Key Biscayne, FL, 4-6 February 19828234 Stanford alumni conference - New York, NY, 26-29 April 19838235 International Congress of Biochemistry, Amsterdam, 1983-1984831 UCLA Symposium Genome Rearrangement - Steamboat Springs, CO, 7-13 April 1984832 International Psoriasis Research Institute meeting, 19 April 1984833 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 29 April-2 May 1984834-5 Plasmids in Bacteria symposium - University of Illinois, Urbana-Champaign, IL, 14-18 May 1984836 16th meeting of Federation of European Biochemical Societies (FEBS) - Moscow, 25-30 June 1984837 American Society for Microbiology (ASM) Conference on Genetics and Molecular Biology of Industrial Microorganisms - Bloomington, IN, 30 September-3 October 1984838 Society for General Microbiology meeting (in honor of Naomi Datta) - Birmingham, England, 8-10 January 1985839 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 21-24 April 19858310 Gould Day - presentation for Gould, Inc. Top Management, 22 May 19858311-12 Biomolecular Engineering Programme (BEP) Symposium on Plasmid Stability - Heraklion, Crete, 16-18 October 19858313 Lita Annenberg Hazen Award, 19868314 Louisa Gross Horwitz Prize, 19868315 Nature's Tokyo Conference - Tokyo, 20-22 January 19868316 Miami Winter Symposia, 3-7 February 19868317 Banbury Conference: The Evolution and Spread of Antibiotic Resistance Genes - Cold Spring Harbor, N.Y., 31 March-3 April 19868318 Genentech, Inc. - partitioning of plasmids during cell division - San Francisco, 7 April 19868319-20 American College of Physicians annual session - San Francisco, 10-13 April 19868321 University of Pennsylvania Alumni Reunion Weekend - Distinguished Graduate Awardee for 1986, 16 May 19868322 Cornell University seminar - Ithaca, NY, 18-20 June 19868323 5th Gordon Research Conference: Extrachromosomal Elements - Colby-Sawyer College, NH, 14-18 July 19868324 International Symposium on Genetics of Industrial Microorganisms - Split, Yugoslavia, 14-20 September 19868325 Bio Fair Tokyo '86 - Tokyo, Japan, 15-18 October 19868326 Scientific Challenges in Biotechnology: Past and Present, 20 October 19868327 Miami Winter Symposium - Miami, FL, 9-13 February 19878328 SIM-UCLA Symposia Colloquium - Lake Tahoe, CA, 8-11 March 19878329 Molecular Bio. of Photosynthetic Procaryotes symposium - University of Wisconsin, Madison, 8-10 June 1987841-2 Reducing Risks from Environmental Chemicals through Biotechnology - Seattle, WA, 19-22 July 1987843 Lilly Research Laboratories - Indianapolis, IN, 9 November 1987844 Medical Technologies lecture - San Francisco, 7 December 1987845 Burroughs Wellcome Scholars' Day - Boca Raton, FL, 18-20 February 1988846 European Molecular Biology Organization (EMBO) / Institut National de la Santé et de la Recherche Médicale (INSERM) workshop - Les Arcs, Savoie, France, 28 February-5 March 1988847 Pasteur Institute seminar - Paris, France, 4 March 1988848 Genetical Society 208th meeting - The John Innes Institute, Norwich, 13-15 April 1988849 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 24-26 April 19888410 NAS Genetics Section meeting - Washington, D.C., 25 April 19888411 University of Pennsylvania - Report of Consultants for the Department of Human Genetics - Philadelphia, 9-10 June 19888412 Fourth American Society for Microbiology (ASM) Conference - Bloomington, IN, 2-7 October 19888413 National Academy of Sciences (NAS) meetings, 1989-19938414 National Academy of Sciences (NAS) regional meeting- UCSF Laurel Heights, 21 February 19898415 UCLA symposium - DNA Replication and Recombination - Keystone, CO, 27 March - 7 April 19898416 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 23-25 April 19898417 Karoliinska trip - Lars Melin defense - Stockholm, 2 June 19898418 American Society for Microbiology (ASM) Conference on Biotechnology - Orlando, FL, 22-25 June 19898419 National Eye Institute - institutional training grant meeting (T32) - Bethesda, MD, 24 August 19898420-21 Wilderness Society symposium - Washington, D.C., 9 September 19898422 National Academy of Sciences (NAS) / Institute of Medicine (IOM) - Washington, D.C., 16-17 October 19898423 University of Pennsylvania School of Medicine Class of 1960 30th Reunion - yearbook, 19908424 Giovanni Lorenzini Prizes for Basic Biomedical Research and for the Advancement of Biomedical Sciences, 19908425 UCLA Molecular and Cellular Biology symposia - Molecular Biology of Streptymycetes, 16-21 January 19908426 National Academy of Sciences (NAS) class membership committee meeting - Washington, D.C., 3 February 19908427 National Academy of Sciences (NAS) annual section meeting, 23-24 April 19908428 Oregon State University visit - Corvallis, OR, 2 May 19908429 Institut de la Vie World Center on Human Destiny meeting - San Francisco, 15 July 19908430-31 Workshop on the Institut de la Vie World Center on Human Destiny - San Francisco, 15 July 19908432-33 New Zealand trip, August 19908434 International Fallen Leaf Lake conference - South Lake Tahoe, 13-16 September 19908435 National Eye Institute (NEI) meeting - Bethesda, MD, 19 October 19908436 Taipei visit, 25 October-7 November 19908437 National Association of Biology Teachers (NABT) convention - Houston, TX, 8 November 19908438 UCLA symposia, 19918439 Miami Biotechnology Winter Symposia, 27 January-Feburary 1 19918440 National Academy of Sciences (NAS) - class membership committee meeting - Irvine, CA, 2 February 1991851 Stockholm trip, 27-30 May 1991852-3 Gordon Conference trip - Extrachromosomal Elements - Plymouth College, NH, 30 June-3 July 1991854 Marine Biological Laboratory - Woods Hole, MA, 6 July-3 September 1991855-6 International Symposium on Biology of Actinomycetes (ISBA) - Madison, WI, 11-16 August 1991857 Erox symposium: Recent Advances in Mammalian Pheromone Research - Paris, 6-9 October 1991858 RNA Processing and mRNA Decay in Prokaryotic Cells - North Falmouth, MA, 27-31 October 1991859 Institute of Molecular Biology (IMB) retreat - Ta-Hsi, Taiwan, 16-19 December 19918510-11 Keystone Symposia on Molecular and Cellular Biology - Keystone, CO, 26 January-2 February 19928512 American Chemical Society (ACS) national meeting and award presentation - San Francisco, 5-10 April 19928513 National Academy of Sciences (NAS) annual meeting materials - Washington, D.C., 26-29 April 19928514 Institut de la Vie - Conference on Science, Technology, and Human Values, 1-2 May 19928515 NATO/ Federation of European Biochemical Societies (FEBS) Advanced Study Institute - Post-Transcriptional Control of Gene Expression - Spetsai, Greece, 3-14 August 19928516 European Molecular Biology Organization (EMBO) workshop: Promiscuous Plasmids - Magalia Castle, Spain, 18-22 September 19928517 5th American Society for Microbiology (ASM) conference: Genetics and Molecular Biology of Industrial Microorganisms - Bloomington, IN, 11-15 October 19928518-19 Institute of Biomedical Sciences (IBMS) / Institute of Molecular Biology (IMB) retreat review - Tapiei, Taiwan, 10-17 December 19928520 Asilomar, 19938521 Burroughs Wellcome advisory committee - Boca Raton, FL, 12-13 February 19938522-23 The University-Industry Interface and Medical Innovation - Stanford, 21-23 February 19938524 National Academy of Sciences (NAS) Regional Roundtables - San Francisco, 22 February 19938525 DNA and Biotechnology - A Celebration of 40 Year of Double Helix - Cold Spring Harbor, NY, 1-3 March 19938526 58th Cold Spring Harbor Lab Symposium - DNA and Chromosomes - Cold Spring Harbor, NY, 2-9 June 19938527 Gordon Research Conference - Plasmid and Chromosome Dynamics - Plymouth College, NH, 5-9 July 1993Born digital Gordon Research Conference, 5-9 July 19938528 Association of Faculties of Pharmacy of Canada (AFPC) Pharmaceutical Biotechnology Conference - Vancouver, B.C., Canada, 31 July 1993Born digital Association of Faculties of Pharmacy of Canada (AFPC) Pharmaceutical Biotechnology Conference, 31 July 19938529 Biocenter/Imp symposium - Vienna, Austria, 23 September 1993Born digital Biocenter/Imp symposium, 23 September 19938530 The Double Helix - Forty Years: Prospective and Perspective - Chicago, 13-16 October 1993Born digital DNA and Biotechnology - A Celebration of 40 Year of Double Helix - Cold Spring Harbor, NY, 13-16 October 19938531 Institute of Medicine (IOM) regional meeting - San Francisco, 4 November 19938532 33rd annual meeting American Society for Cell Biology (ASCB)- New Orleans, 11-15 December 19938533 Institute of Molecular Biology (IMB) annual retreat -Shih-Men Reservoir, Taiwan, 15-18 December 19938534 University of California Davis Rowe Chair advisory committee meeting - San Francisco, 4 January 19948535 Burroughs Wellcome Experimental Therapeutics Advisory Committee - Boca Raton, FL, 10-20 February 19948536 Molecular Biology of Actinomycetes - Woods Hole, MA, 18-22 April 19948537 NATO Advanced Research Workshop - Post-transcriptional Control of Gene Expression - Aruba, 29 April-3 May 1994861 Spetsai summer school - Spetsai, Greece, May 1994862 New Challenges and Future Prospects of Biotechnology in Israel - Tel Aviv University, Israel, 24-26 May 1994863 Sixth International Conference on Thinking, 17-22 July 1994864 International Conference on Plasmid Biology - Banff, Canada, 25-30 August 1994865 University of Pennsylvania campaign steering committee, 12 September 1994866-9 American Society for Microbiology (ASM) conference, 22-26 October 19948610 American Society for Cell Biology (ASCB) 34th annual meeting - San Francisco, 10-14 December 19948611 Burroughs Wellcome Fund - Experimental Therapeutics Advisory Committee (ETAC) - Florida, 10-11 February 19958612 2nd International Pharmaceutical Biotechnology Conference - University of Ghent, Belgium, 23-27 April 19958613-14 Penn graduation, 19-23 May 19958615 UNESCO - Vienna, 6-12 June 19958616 Gordon Conference - Plymouth College, NH, 2-7 July 19958617 Molecular Genetics of Bacteria and Phages - Cold Spring Harbor Laboratory, NY, 22-27 August 19958618 Albert Lasker Awards - New York City [photograph], 28-29 September 19958619 Institute of Molecular Biology (IMB) Retreat - Taipei, Taiwan, 18-21 December 19958620 Universities Space Research Association (USRA), 19968621-22 Burroughs Wellcome Fund Joint Experimental Therapeutics/Pharmacology/Toxicology Advisory committee meeting, 8-10 February 19968623 University of British Columbia, Canada, 25-27 March 19968624 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 27-30 April 19968625 Institute of Molecular Biology (IMB) trip (Anniversary) [photograph], 18-26 May 19968626 FASEB Summer Research Conference - Copper Mountain, CO, 30 June-5 July 19968627 Vysis teleconference, 7 August 19968628-29 Alpbach European Forum - Tyrol, Austria, 18-22 August 19968630Cancer Biology Asilomar, 20-22 September 19968631 COGENE business meeting - Washington, D.C., 23-27 September 19968632 Genomics Beyond the DNA Sequence - Howard Hughes Medical Institute, Chevy Chase, MD, 24-25 September 19968633-34 International OJI Seminar - Hakone, Japan [photograph], 10-14 November 19968635 Keystone Symposia - Genetics of Human Cancer: Pathogenesis & Diagnosis - Keystone Resort, CO, 27 January-2 February 1997Born digital Keystone Symposia - Genetics of Human Cancer: Pathogenesis & Diagnosis, 27 January-2 February 19978636 Burroughs Wellcome - San Antonio, TX, 6-8 February 19978637 Isis Pharmaceuticals - Carlsbad, CA, 13 February 19978638 Life Technologies, Inc. (LTI) - Washington, D.C., 12-14 March 19978639 Taiwan - Frontiers in Prokaryote Biology, 27-30 March 19978640 Abbott Labs - Chicago, 24-25 April 19978641 National Academy of Sciences (NAS) - Washington, D.C., 26-27 April 1997Born digital National Academy of Sciences (NAS), 26-27 April 19978642 Harvard seminar, 29 April 19978643 Chemical Heritage Foundation - Philadelphia, 13 June 19978644 Plasmid Gordon Conference- Plymouth State College, NH, 13-18 July 19978645 Russell-Welsh Luncheon - Sheraton Palace Hotel, San Francisco, 30 July 19978646 Molecular Genetics of Cancer, American Association for Cancer Research (AACR)/European Association for Cancer Research (EACR) meeting - Oxford, England, 9-12 September 1997Born digital Molecular Genetics of Cancer, American Association for Cancer Research (AACR)/European Association for Cancer Research (EACR) meeting, 9-12 September 19978647Cancer Biology Program annual conference - Asilomar, CA, 16-18 September 19978648 Palo Alto VA Med Center seminar, 30 September 19978649 Life Technologies, Inc. (LTI) - Washington, D.C., 30 September-2 October 19978650 Bob Rownd Memorial Symposium - Detroit, 3-4 October 19978651 Banbury Center - Cold Spring Harbor, NY, 24-26 October 1997Born digital Japan trip, November 19978652 Princess Takamatsu Cancer Research, 17-20 November 19978653 Genentech meeting - San Francisco, 9 December 19978654-55 American Society for Cell Biology, Biorad - Washington D.C., 13-15 December 19978656 Keystone symposia conferences, 19988657 Pfizer - Groton, CT, 21 January 19988658 Life Technologies, Inc. (LTI) - Rockville, MD, 22 January 1998Born digital Life Technologies, Inc. (LTI), 22 January 19988659 Workshop: Macromolecular Interactions at Initiation of Replication in Prokaryotic Extrachromosomal Elements - Madrid, 9-11 February 1998Born digital Workshop: Macromolecular Interactions at Initiation of Replication in Prokaryotic Extrachromosomal Elements, 9-11 February 19988660 Markey Distinguished Seminar, Institute for Genetic Medicine - USC Medical Center, 22 April 1998Born digital Markey Distinguished Seminar, Institute for Genetic Medicine, 22 April 1998871 National Academy of Sciences (NAS) - Washington, D.C., 25-27 April 1998872 Genetics and Molecular Biology - Stanford, 2 May 1998873 Wolf Foundation 20th anniversary symposium - Jerusalem, 11-12 May 1998874 American Society for Microbiology (ASM) general meeting, Division H symposia: Translation and mRNA decay-new insights from bacteria and yeast - Atlanta, 17-21 May 1998Born digital American Society for Microbiology (ASM) general meeting, Division H symposia: Translation and mRNA decay-new insights from bacteria and yeast, 17-21 May 1998875 Julian Davies Symposium - University of British Columbia, Vancouver, 22-24 May 1998876 American Society for Microbiology (ASM) Vaccine Research Program G330, 10 June 1998877 8th International Symposium: Genetics of Industrial Microorganisms - Jerusalem, Israel, 28 June-3 July 1998Born digital 8th International Symposium: Genetics of Industrial Microorganisms, 28 June-3 July 1998878 Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference - Wilsonville, OR, 5-10 July 1998Born digital Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference, 5-10 July 1998879 Inventors' Hall of Fame - Akron, OH, 15 July 19988710 NASA - Moffett Field, CA, 20-22 July 19988711 Life Technologies, Inc. - Rockville, MD, 26-28 July 19988712 Society for Industrial Microbiology (SIM) - Denver, CO, 9-13 August 19988713-14 David Hopwood Retirement Symposium, Society for General Microbiology and Genetical Society - Norwich, UK, 8-10 September 19988715 Dept. of Genetics annual retreat - Monterey Beach, CA, 16-18 September 19988716 California Institute for Medical Research 35th anniversary - Santa Clara, CA, 2 October 19988717 California Institute for Medical Research: Medical Grand Rounds -Santa Clara Valley Med. Ctr., CA, 2 October 19988718 B/CW Conference - Stanford, Hoover Institution, 16-18 November 19988719 Jerry Hurwitz symposium - New York, NY, 20 November 19988720-22 Defense Advanced Research Projects Agency (DARPA) meeting - Monterey, CA, 7-12 February 1999Born digital Defense Advanced Research Projects Agency (DARPA) meeting, 7-12 February 19998723 National Academy of Sciences (NAS) colloquium - Irvine, CA, 20-21 February 19998724 Victor C.Y. Tseng luncheon - Stanford, 5 March 19998725 Gene Therapy: Prospects for the Next Decade - Stanford, 11 March 19998726 Biotechnology at 25 - University of California, Berkeley, Bancroft Library, 13 March 19998727 Vienna Biocenter Recess - Vienna, 19-20 March 19998728 Human Genome meeting - Brisbane, Australia, 27-30 March 19998729 Thomas White meeting - Stanford, c.1 April 1999Born digital China, April 19998730 90th Annual Meeting of the American Association for Cancer Research - Philadelphia, 10-14 April 19998731 American Society for Microbiology (ASM) general meeting - Chicago, 30 May-3 June 19998732 Hao Ran workshop - Santa Cruz, CA, 9-19 August 19998733-34 Genetics Department retreat - Seaside, CA, 15-17 September 19998735 Bacterial Genomics meeting - Stanford, 27 September 19998736 mRNA symposium - San Francisco, 10-12 October 1999Born digital mRNA symposium, 10-12 October 19998737 International Symposium on the Biology of Actinomycetes (ISBA) - Crete; Greece - cancelled, 20 October-1 November 1999Born digital International Symposium on the Biology of Actinomycetes (ISBA), 20 October-1 November 19998738 Singapore Life Sciences Investment Funds: Doreen Chia, Director of SF Centre of EDB, 12 November 19998739 American Society for Cell Biology - Washington, D.C., 11-15 December 19998740 Molecular Medicine Seminar Series - San Antonio, TX, 20008741Cancer Research at the Millennium - Houston, TX, 9-12 January 20008742 Defense Advanced Research Projects Agency (DARPA) conference - Ft. Lauderdale, FL, 30 January-4 February 2000Born digital Defense Advanced Research Projects Agency (DARPA) conference, 30 January-4 February 20008743 National Center for Healthcare Leadership (NCHL) event, 22 March 20008744 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 29 April-2 May 2000Born digital Hong Kong trip, May 20008745 Center for Clinical Sciences Research building opening celebration - Stanford, 18 May 20008746-47 University of Pennsylvania School of Medicine Class of 1960 40th Reunion - yearbook, 19-20 May 20008748 Kirsch Foundation Scientific Advisory Board - San Jose, CA, 22 May 20008749 Burroughs Wellcome Fund - Research Triangle Park, NC, 25 May 20008750 RNA 2000 Fifth Annual Meeting of the RNA Society - Madison, WI, 30 May-4 June 2000881-5 Federation of American Societies for Experimental Biology (FASEB) conference: Post-transcriptional Control of Gene Expression � Copper Mountain, CO, 16-21 July 2000Born digital Federation of American Societies for Experimental Biology (FASEB) conference: Post-transcriptional Control of Gene Expression, 16-21 July 2000886Cancer Genetics & Tumor Suppressor Genes Meeting - Cold Spring Harbor Laboratory, NY, 16-20 August 2000887 Kirsch Foundation Scientific Advisory Board - Berkeley, CA, 4 October 2000888 R.W. Johnson Pharmaceutical Research Institute symposium - San Diego, CA, 15-16 October 2000Born digital R.W. Johnson Pharmaceutical Research Institute symposium, 15-16 October 2000889 Institute of Medicine (IOM) annual meeting - Washington, D.C. - invitation, 15-17 October 2000Born digital Rockefeller University lecture, October 20008810 American Chemical Society: Inventors Make a Difference Day - Santa Clara, CA, 23 October 20008811 National Academy of Sciences (NAS) Colloquium: Links between Recombination and Replication . . . - Irvine, CA, 10-12 November 20008812 Council of Advisors on Innovation and Technology Committee on Biotechnology, 24 November 20008813 Otsuka America Pharmaceutical - Gaithersburg, MD, 27 November 2000Born digital Otsuka America Pharmaceutical, 27 November 20008814 Pherinpharmaceuticals round table - Mountain View, CA, 5 December 20008815 40th Annual meeting of the American Society for Cell Biology (ASCB) - Mountain View, CA, 9-13 December 20008816 University of Tokyo Forum 2000 - Stanford, 14-15 December 20008817 Remington 70th Birthday Festschrift - Stanford, 19 January 2001Born digital Taiwan visit, February 20018818-19 Defense Advanced Research Projects Agency (DARPA) conference - San Diego, CA, 4-7 February 2001Born digital Defense Advanced Research Projects Agency (DARPA) conference, 4-7 February 20018820 National Academy of Sciences (NAS) regional meeting, February 20018821 Singapore Economic Development Board (EDB) - San Francisco, 26 February 20018822 American Association for Cancer Research (AACR) 92nd annual meeting - New Orleans - brochure, 24-28 March 20018823 American Physiological Society (APS) annual meeting - brochure, 31 March-4 April 20018824 Research Technical Review, 2 April 20018825 California Cancer Research Program (CCRP) - Sacramento [2 zip discs], 18 April 2001Born digital California Cancer Research Program (CCRP), 18 April 20018826 Human Genome meeting - Edinburgh, Scotland - announcement, 19-22 April 20018827 Lemelson-MIT awards - Washington, D.C. - invitation, 25 April 20018828 Association of American Physicians annual dinner - Chicago - invitation, 28 April 20018829 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 28 April-1 May 20018830 SAB meeting - San Jose, 22 May 20018831 10th Bioinformatics and Genome Research conference - San Francisco, 18-19 June 2001Born digital 10th Bioinformatics and Genome Research conference, 18-19 June 20018832 Otsuka presentation - Tokyo, Japan [zip disc], 4 July 2001Born digital Otsuka presentation, 4 July 20018833 International Symposium on the Biology of Actinomycetes (ISBA) - Vancouver, B.C., 5-10 August 2001Born digital International Symposium on the Biology of Actinomycetes (ISBA), 5-10 August 20018834 Defense Advanced Research Projects Agency (DARPA) meeting - Washington, D.C., 16 August 2001Born digital Defense Advanced Research Projects Agency (DARPA) meeting, 16 August 20018835 BBC interview - Palo Alto, 22 August 20018836 University of Pennsylvania Opening Convocation - Philadelphia, 5 September 20018837 Comparative Genomics of Streptomyces and Mycobacteria - Norwich, England, 12 September 2001Born digital J.P. Morgan CEO offsite, 12-14 September 20018838 National Foundation for Cancer Research - Washington, D.C., 13-15 September 20018839 National Inventors Hall of Fame - Akron, OH, 15 September 2001Born digital Singapore Economic Development Board (EDB), 18 September 20018840-41 Biomedical Asia 2001 - Singapore, 19-21 September 2001Born digital Biomedical Asia 2001, 19-21 September 2001Born digital National Foundation for Cancer Research (NFCR) triannual conference, September 20018842 54th Annual Symposium on Fundamental Cancer Research - Houston, 2-5 October 20018843 Institute of Medicine annual meeting - Washington, D.C., 15-16 October 20018844 American Society for Cell Biology 41st annual meeting - Washington, D.C., 8-12 December 20018845 Singapore Economic Development Board (EDB): 4th IAC meeting - London, 6 March 2002Born digital Singapore Economic Development Board (EDB): 4th IAC meeting, 6 March 2002Born digital Breast Cancer Research Program (BCRP), 8-10 March 20028846 Defense Advanced Research Projects Agency (DARPA) UPC PI conference - Lexington, KY, 6-10 April 2002Born digital Defense Advanced Research Projects Agency (DARPA) UPC PI conference, 6-10 April 2002891 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 27-30 April 2002892 Kirsch Investigator seminar - San Jose, 22 May 2002893 JP Morgan Partners' Healthcare CEO Conference - Aspen, CO, 5-7 June 2002894 Plasmid Biology '02 - Pittsburgh, PA, 22-28 June 2002Born digital Plasmid Biology '02, 22-28 June 2002895 Federation of American Societies for Experimental Biology (FASEB) - Tucson, AZ, 6-11 July 2002Born digital Federation of American Societies for Experimental Biology (FASEB), 6-11 July 2002896 Defense Advanced Research Projects Agency (DARPA) UPC Topic meeting - Frederick, MD, 7 August 2002Born digital Defense Advanced Research Projects Agency (DARPA) UPC Topic meeting, 7 August 2002897 Department of Genetics annual retreat - Monterey, CA, 18-20 September 2002Born digital Department of Genetics annual retreat, 18-20 September 2002898-9 Singapore Economic Development Board (EDB) meeting and Biomedical and Biotechnica Asia 2002 - Singapore, 28-30 October 2002Born digital Singapore Economic Development Board (EDB) meeting and Biomedical and Biotechnica Asia 2002, 28-30 October 20028910 Meetings not attended - announcements, 20028911 Fairchild Review meeting, 7 January 20038912 50th Anniversary DNA Double Helix Gala Celebration - New York, N.Y. - invitation, 28 February 20038913 Singapore Economic Development Board (EDB) meeting - Munich, 26 March 2003Born digital Singapore Economic Development Board (EDB) meeting, 26 March 20038914 Defense Advanced Research Projects Agency (DARPA) UPC PI conference - Galveston, TX, 6-10 April 2003Born digital Defense Advanced Research Projects Agency (DARPA) UPC PI conference, 6-10 April 20038915 From Double Helix to Human Sequence and Beyond - Bethesda, MD, 14-15 April 20038916 50th Anniversary of the Elucidation of the Double Helix Structure of DNA - London - invitation, 23 April 20038917 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 26-29 April 2003Born digital National Academy of Sciences (NAS) annual meeting, 26-29 April 20038918 2003 Colloquium on the Biology of Aging - Woods Hole, MA, 14-16 August 20038919 Society for General Microbiology - Fred Griffith Prize Lectureship - Manchester, England, 8-11 September 20038920 National Foundation for Cancer Research (NFCR) Biofunding Summit - Phoenix, AZ, 16-19 October 2003Born digital National Foundation for Cancer Research (NFCR) Biofunding Summit, 16-19 October 20038921 Institute of Medicine (IOM) of the National academies 33rd annual meeting - Washington, D.C., 27-28 October 20038922 Singapore Economic Development Board (EDB) Stem Cell conference and 7th IAC meeting - Singapore, 29-31 October 2003Born digital Singapore Economic Development Board (EDB) Stem Cell conference and 7th IAC meeting, 29-31 October 20038923 Apax Partners healthcare advisory board meeting, St. Helena, California - agenda, 3-4 November 20038924 International Symposium on the Biology of Actinomycetes - Melbourne, Australia, 1-5 December 2003Born digital International Symposium on the Biology of Actinomycetes, 1-5 December 2003Born digital National Biodefense Analysis and Counterdefense Center Threat Assessment Bacteriology Working Group meeting - Buellton, CA, 23-24 January 20048925 National Academy of Sciences (NAS) Interdisciplinary Research Committee meeting - Washington, D.C., 28-30 January 2004Born digital National Academy of Sciences (NAS) Interdisciplinary Research Committee meeting, 28-30 January 20048926 National Academy of Sciences (NAS) Committee on Interdisciplinary Research meeting - Washington, D.C., 22-23 March 20048927-28 Singapore Economic Development Board (EDB) - 8th IAC meeting - Boston, 23 March 2004Born digital Singapore Economic Development Board (EDB) - 8th IAC meeting, 23 March 20048929 National Academy of Sciences (NAS) annual meeting - Washington, D.C., 17-20 April 20048930 Albany Prize - Albany, NY, 22-23 April 2004Born digital Albany Prize, 22-23 April 20048931 Lemelson-MIT award ceremony - Washington, D.C., 23 April 20048932 Intercell event - Vienna, 23 April 20048933 Ecocyc advisory committee meeting - Menlo Park, CA, 10 May 20048934 Defense Advanced Research Projects Agency (DARPA) PC/AAX 2004 PI meeting - Napa, CA [CD-RW], 11-13 May 2004Born digital Defense Advanced Research Projects Agency (DARPA) PC/AAX 2004 PI meeting, 11-13 May 20048935 Stanford University Commencement - Palo Alto, CA, 12-13 June 20048936 Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference: Post-Transcriptional Control of Gene Expression - Tucson, AZ, 26 June-1 July 2004Born digital Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference: Post-Transcriptional Control of Gene Expression, 26 June-1 July 20048937 Defense Advanced Research Projects Agency (DARPA)/DSO Endogenous Defense workshop - Fairfax, VA, 12-13 July 2004Born digital Defense Advanced Research Projects Agency (DARPA)/DSO Endogenous Defense workshop, 12-13 July 2004901 The Shaw Prize - Hong Kong, 7 September 2004902 Plasmid Biology 2004 - Corfu, Greece - cancelled trip, 15-21 September 2004Born digital Plasmid Biology 2004 - canceled trip, 15-21 September 2004903 Apax Partners, Inc. - Int'l Healthcare Advisory Board - New York, 28-30 September 2004Born digital Apax Partners, Inc. - Int'l Healthcare Advisory Board, 28-30 September 2004904 Singapore Economic Development Board (EDB) - 9th IAC meeting - Singapore, 10-11 October 2004Born digital Singapore Economic Development Board (EDB) - 9th IAC meeting, 10-11 October 2004905 Ellison Foundation Aging Scholars colloquium - Novato, CA, 23-25 October 2004906 National Defense University - Washington, D.C. - did not attend, 10 November 2004907 National Academy of Sciences (NAS) regional meeting - Berkeley, CA, 10 February 2005908 Biotechnology in the 21st Century: a Symposium Honoring S. N. Cohen - Silverado Resort, Napa, CA, 18-20 February 2005909 Defense Advanced Research Projects Agency (DARPA) Pathogen Countermeasures / Accelerated Anthrax 2004 PI meeting - Fort Lauderdale, FL, 9-11 March 2005Born digital Defense Advanced Research Projects Agency (DARPA) Pathogen Countermeasures / Accelerated Anthrax 2004 PI meeting, 9-11 March 20059010 Xenogen 2005 SAB meeting - San Francisco, 3-4 April 20059011 Semmering conference - Vienna, 14-17 April 2005Born digital Semmering conference, 14-17 April 20059012 EcoCyc Advisory Board meeting - Menlo Park, 29 April 20059013 Albany Prize Teaching Day - Albany, NY, 2 May 2005Born digital Albany Prize Teaching Day, 2 May 20059014-15 University of Pennsylvania School of Medicine reunion - Philadelphia, 13-15 May 20059016-17 Gates Foundation: Biology of Persistence meeting - Madrid, 17-18 May 2005Born digital Gates Foundation: Biology of Persistence meeting, 17-18 May 20059018 Weizmann Institute Dinner Celebrating Scientific Achievement - program, 19 May 20059019 Europic 2005: Picorna Virus symposium - Lunteren, Netherlands, 23-29 May 20059020 Stanford University Commencement - Palo Alto, CA - invitation, 12 June 20059021 Ellison Foundation: Colloquium on the Biology of Aging - Woods Hole, MA, 18-20 August 2005Born digital Ellison Foundation: Colloquium on the Biology of Aging, 18-20 August 20059022Cancer Biology 28th annual conference - Stanford, 20-22 September 2005Born digital International Consortium on Anti-Virals - Trent University, Peterborough, Canada, 23-25 September 20059023 Joshua Lederberg 80th Birthday symposium - New York, NY, 17 October 2005Born digital Joshua Lederberg 80th Birthday symposium, 17 October 20059024-25 Chinese University of Hong Kong Distinguished Visiting Scholar - Hong Kong, 31 October-6 November 2005Born digital Chinese University of Hong Kong Distinguished Visiting Scholar, 31 October-6 November 20059026 United College - Distinguished Visiting Scholar Lectures - program, 1 and 3 November 20059027 Frontiers of Biomedical Research: HKU Faculty Research symposium - Hong Kong, 2 December 2005Born digital Frontiers of Biomedical Research: HKU Faculty Research symposium, 2 December 2005Born digital Intercell SAB - Vienna, February 2006Born digital Genetics of Industrial Microorganisms - 10th international symposium - Prague, Czech Republic, 24-28 June 2006Born digital Ellison Medical Foundation, August 2006Born digital Genetics Department retreat, September 2006Born digital Plasmid Biology - South Lake Tahoe, CA, 23-27 September 2006Born digital World Immune Regulation Meeting - Switzerland - cancelled, 11-15 April 2007Born digital Defense Threat Reduction Agency (DTRA) - Bethesda, MD, April 2007Born digital Intercell SAB - Vienna, 9-12 April 2007Born digital American Society for Microbiology (ASM) - Toronto, Canada - cancelled, 21-25 May 2007Born digital Aspen Health Forum - Aspen, CO, 3-6 October 2007Born digital Defense Threat Reduction Agency (DTRA) - Philadelphia, 4-7 November 2007Born digital Biodefense Research Conference, January 2008Born digital Charter Life Sciences Scientific Advisory Board, 5 January 2008Born digital World Immune Regulation Meeting - Switzerland, 17-20 March 2008Born digital National Academy of Sciences (NAS) annual meeting - Washington, D.C., 26-29 April 2008Born digital Forum on Microbial Threats - Washington, D.C., 20-21 May 2008Born digital Chris Miller 40th anniversary party, 28 June 2008Born digital Defense Threat Reduction Agency (DTRA) site visit - Stanford, 31 July 2008Born digital Federation of American Societies for Experimental Biology (FASEB) - Lucca, Italy - cancelled, September 2008Born digital Lasker Award ceremony - New York, NY, 22 September 2008Born digital Intercell - Ehrlich Symposium- Vienna, Austria, October 2008Born digital Gisou Van Der Groot talk, December 2008Born digital Defense Threat Reduction Agency (DTRA) Threat Reduction Advisory Committee (TRAC) panel review - Washington, D.C., February 2009Born digital National Academy of Sciences (NAS) regional meeting - Stanford, 12 February 2009Born digital Defense Threat Reduction Agency (DTRA) Transformational Medical Technologies Initiative (TMTI) site visit - Stanford, 15 July 2009Born digital International Symposium on the Biology of Actinomycetes (ISBA) - Shanghai, 20-25 August 2009Born digital Defense Threat Reduction Agency (DTRA), October 2009Born digital Double Helix Medals dinner - Cold Spring Harbor Laboratory, 10 November 2009Born digital Chemical and Biological Sciences Science and Technology conference - Dallas, TX, 16-20 November 2009Born digital Defense Threat Reduction Agency (DTRA) Transformational Medical Technologies Initiative (TMTI) quarterly meeting - Springfield, VA, 4 February 2010Born digital Defense Threat Reduction Agency (DTRA) Transformational Medical Technologies Initiative (TMTI) site visit, 24 March 2010Born digital University of Pennsylvania reunion - Philadelphia, 14-16 May 2010Born digital Uppsala and Copenhagen - cancelled, 23 May 2010Born digital GlaxoSmithKline - Philadelphia, 30 September 2010Born digital Academia Sinica - Taiwan and China, 7-18 October 2010Born digital Chemical and Biological Sciences Science and Technology conference - Orlando, Fl., 15-19 November 2010Born digital Prion meeting - University of California San Francisco - postponed, 13-14 January 2011Born digital Functional Genetics meeting, 27 January 2011Born digital Diagnostic and Disease Surveillance (CBDX) quarterly meeting - Quantico, VA, 12 April 2011Born digital Uppsala and Copenhagen, 14-21 May 2011Born digital Chris Moore's graduation lunch - Palo Alto, CA, 21 June 2011Born digital Cohen barbecue - chez Cohen, 8 July 2011Born digital Dean's Medal presentation - Stanford, 10 September 2011Born digital Chemical and Biological Sciences Science and Technology conference - Las Vegas, 14-18 November 2011Born digital Center for Digital Health Information conference - Palm Springs, CA, 29 February 2012Born digital Prion Review meeting - San Francisco - SNC did not attend, 3-4 May 2012Born digital Federation of American Societies for Experimental Biology (FASEB) - Post Transcriptional Control of Gene Expression: Mechanisms of mRNA Decay - Steamboat Springs, CO, 24-29 June 2012Born digital Defense Threat Reduction Agency (DTRA) Basic Research Tech Review - Springfield, VA, 30 July 2012Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 1st meeting - Washington, D.C., 12-13 September 2012Born digital International Biotechnology Symposium - Daegu, South Korea, 16-21 September 2012Born digital FGI board meeting - Bethesda, MD, 5-11 October 2012Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 2nd meeting - Washington, D.C., 6-7 December 2012Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 3rd meeting - Washington, D.C., 21-22 February 2013Born digital Gordon conference - Ventura, CA, 10-15 March 2013Born digital Regulating with RNA in Bacteria - Wurzburg, Germany, 4-8 June 2013Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 4th meeting - Washington, D.C., 22-23 July 2013Born digital Taiwan visit, 4-9 November 2013Born digital Life Sciences Event - San Francisco, 18 November 2013Born digital BayBio Pantheon Awards dinner - San Francisco, 5 December 2013Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 5th meeting - Washington, D.C., 11-12 February 2014Born digital Center for Digital Health Information (CDHI) 9th annual HD Therapeutics conference - Palm Springs, CA, 24-27 February 2014Born digital Translational Research and Applied Medicine (TRAM) symposium - Stanford, 16 May 2014Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 6th meeting - Washington, D.C., 28-29 May 2014Born digital Meeting on the History of Plasmids - Cold Spring Harbor Laboratory, N.Y., 21-24 September 2014926 Meeting on the History of Plasmids - Cold Spring Harbor, New York - "LSF news Other Event Recaps--Cold Spring Harbor Laboratory History Conference: Plasmid Biology", LSF Magazine, Winter 2015, 21-24 September 2014Born digital Institute of Medicine dinner - San Francisco, 28 September 2014Born digital Sanger symposium - San Diego, CA, 5 November 2014Born digital Hal Holman 90th birthday dinner - Menlo Park, CA, 17 January 2015Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 7th meeting - Washington, D.C., 5-6 February 2015Born digital Center for Digital Health Information (CDHI) 10th annual HD Therapeutics conference - Palm Springs, CA, 23-26 February 2015Born digital Stanford Center for Genomics and Personalized Medicine (SCGPM) - SGTP retreat - Menlo Park, CA, 3 April 2015Born digital Translational Research and Applied Medicine (TRAM) presentation - Stanford, 15 April 2015Born digital International Society for Extracellular Vesicles (ISEV) - Bethesda, Md. - cancelled, 22-26 April 2015Born digital Standing Committee of Department of Defense's Programs to Counter Biological Threats - 8th meeting - Washington, D.C. - cancelled, 7-8 May 2015Born digital University of Pennsylvania School of Medicine 250th Anniversary - Philadelphia - cancelled, 15-16 May 2015Born digital World Medicine Summit - Macau, 7-9 July 2015Born digital Lemelson Foundation 20th anniversary celebration - Washington, D.C., 17-18 September 2015Born digital Visit to Wilma - Washington, D.C., 22 December 2015Born digital Dinner honoring National Science and Technology Medal recipients - Washington, D.C., 22 January 2016Born digital Center for Digital Health Information (CDHI) 11th annual HD Therapeutics conference - Palm Springs, CA, 22-25 February 2016Born digital Harrington Annual Scientific symposium - Cleveland - cancelled, 25-26 May 2016Born digital Bio convention and Heritage Award ceremony - San Francisco, 6-9 June 2016Born digital American Society for Microbiology (ASM) Microbe 2016 - Washington, D.C. - cancelled, 16-20 June 2016Born digital SPARK 10th anniversary symposium - Stanford, 18 October 2016Born digital National Institute of Neurological Disorders and Stroke (NINDS) 3D CNS Disease Modeling workshop - San Diego, Ca. - cancelled, 11 November 2016 Series 13: Memberships and Awards, 1955-2016 Awards 93 American Legion Auxiliary - medal, undatedMap Drawer 242 Could animal genes be introduced into bacteria, and would they replicate there? framed experiment summary, undated93 Green jade seal with name Stanley N. Cohen carved in English and Chinese, undated93 ЛЕНИН [LENIN in Russian alphabet] - pin, undated93 University of Pennsylvania alumni - keychain, undated9028 Who's Who in American Colleges and Universities - certificate, 1955 Rutgers Phi Beta Kappa 9029 Certificate, 25 April 195693 Key on chain, 1956 Roche Institute of Molecular Biology V.D. Mattia Award 129 Announcement and clippings [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 1977Map Drawer 243 Certificate, 1977 Albert Lasker Basic Medical Research Award Map Drawer 17 Lasker Award Certificate [framed], 21 November 198098 Lasker Award Statuette, 21 November 19809030-33 General, 21 November 198097 Program and certificate binder, 21 November 198096 Peninsula Patent Law Association Inventor of the Year Award - plaque, 1981 Wolf Foundation Prize in Medicine Map Drawer 242 Certificate, 19819034 Presentation program, 1981213 Telegram and press releases [in Newspaper and magazine clippings, press releases, brochures 1978-2004], 19819035 American Chemical Society Division of Microbial and Biochemical Technology Marvin J. Johnson Award in Microbial and Biochemical Technology - plaque, 26 August 1981 NIAID Kinyoun Lecture 9036 Plaque, 3 December 1981214 Program [in Newspaper and magazine clippings, press releases, brochures 1978-2004], 3 December 19819037 California Inventors Hall of Fame - plaque, 19829038 American Chemical Society Special Award - plaque, April 198293 Shemyakin Institute of Bio-organic Chemistry of the USSR Academy of Sciences - medal, 1984222 Miami Winter Symposium Distinguished Service Award - certificate [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 198694 Stanley N. Cohen Miami Winter Symposium Distinguished Service award - Lab coat, 3-7 February 1986222 Pennsylvania State College of Science Russel Marker Lectures in Genetic Engineering - program [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 27-29 April 1988 University of Pennsylvania Distinguished Graduate Award Map Drawer 243 Certificate, 16 May 19869039 Program, 16 May 1986223 City of Medicine Award - memorabilia [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 1988 Cetus Corporation Award for Research in Biotechnology 223 Clippings [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 198893 Medal, 1988 Prix LVMH de l'Institut de la Vie 9040-41 Award ceremony, 5 July 1988Map Drawer 243 Certificates, 5 July 19889042 Letter from Maurice Marois, presentation program, and acceptance speech, 5 July 198893 Medal, 4 July 19889043 Press kit, 5 July 19889044-45 Program, 5 July 1988 National Medal of Science Map Drawer 243 Certificate, 15 July 198893 Medal, 15 July 1988223 Memorabilia [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 15 July 19889046 Photograph of ceremony, signed by President Reagan, 15 July 19889047 Presentation program, 15 July 1988 National Biotechnology Ventures Award Map Drawer 241 Certificate, 198993 Medal, 1989 National Medal of Technology Map Drawer 243 Certificate, 17 October 198993 Medal, 17 October 1989223 Memorabilia [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 17 October 1989911 Photograph of award ceremony, signed by President George H. W. Bush, 17 October 19894 Joint award ceremony for National Medal of Science and Technology [ceremony video] [vhs videocassette], 17 October 1989912 Programs, 17 October 1989Map Drawer 241 National Association of Biology Teachers Distinguished Service Award - certificate, 28 October 1989 Perth Amboy High School Hall of Fame 96 Plaque, 1990Map Drawer 243 New Jersey General Assembly Resolution, 19904 PAHS Hall of Fame [ceremony video] [vhs videocassette], 1990 Helmut Horten Foundation Award Map Drawer 242 Certificate, 13 October 1993913 Presentation program, 13 October 199393 Kwoh-Ting Lie Professor in the School of Medicine - award, 1993 Rutgers honorary doctor of science degree 96 Certificate, 1994Map Drawer 241 Diploma, 1994914 Diploma, 1994915 Directories, 200194 Hood and gown, 1994915 Presentation and dinner program, 199494 Statuette, 1994 University of Pennsylvania honorary doctor of science degree Map Drawer 242 Certificate, 22 May 199594 Hood and gown, 22 May 19958614 Letter from Judith Rodin, 2 November 199493 Medal, 22 May 1995Map Drawer 243 University of Pennsylvania National Alumni Council - certificate, 16 May 199694 World Science and Technology Leader - plaque, 1996 Lemelson-MIT prize 916 Program, 11 April 19964 Lemelson-MIT prize progrmam compilation [presentation ceremony, speeches, pless clips] [2 vhs videocassettes], 11 April 1996Map Drawer 243 University of Pennsylvania Health System - resolution of appreciation, 8 September 1997 National Inventors Hall of Fame 917 Certificate of induction, 8 December 20014 2001 Induction ceremony video - [vhs videocassette], 8 December 20014 2001 Induction ceremony video scratch trak - [vhs videocassette], 200193 Medal, 8 December 200193 Medal - patent no. 4,237,224, genetic engineering, 8 December 2001918-9 Presentation program and book, 8 December 20014 2000 Induction ceremony video - [vhs videocassette], 20009110 Ellison Medical Foundation Senior Scholar in Aging Award - certificate, 200297 National Foundation for Cancer Research, in memory of Sam Liesching - plaque, 18 January 20029111 University of Pennsylvania Resolution of Appreciation, 21 June 200294 Society for General Microbiology - certificate, 2003 Albany Medical Center Prize in Medicine and Biomedical Research 314 Clippings [in Newspaper and magazine clippings, press releases, brochures 2001-2013], 23 April 20049112 Photo album, 23 April 20049113 Presentation program, 23 April 2004 The Shaw Prize in Life Science and Medicine 93 Medal, 7 September 2004Map Drawer 243 Certificate, 7 September 20049114 Letter from Mona Shaw, 7 September 20049115 Presentation program, 7 September 20049116 Dr. Cohen's presentation [transcript]; award ceremony video (English and Cantonese) [2 dvds], 7 September 20049117 The Economist's Innovation Award in Bioscience - presentation program and watercolor portrait, 14-15 November 2005 Einstein Professor of the Chinese Academy of Sciences 314 Certificate [in Newspaper and magazine clippings, press releases, brochures 2001-2013], 200693 Plaque, 2006 University of Pennsylvania Alumni Award of Merit 315 Brochure [in Newspaper and magazine clippings, press releases, brochures 2001-2013], 2006Map Drawer 243 Certificate, 200693 John Stearns Award for Lifetime Achievement in Medicine - medal, 20079118 Journal of Cellular Physiology - cover, June 200893 Stanford University Kwoh-Ting Li Professor in the School of Medicine - medal, 2009 Cold Spring Harbor Laboratory Double Helix Medal 316 Brochure [in Newspaper and magazine clippings, press releases, brochures 2001-2013], 11 October 200993 Medal, 11 October 20094 Presentation ceremony [vhs videocassette], 11 October 2009 Stanford University School of Medicine Dean's Medal 9119 Congressional Record excerpt honoring Dr. Cohen, 10 September 2011316 Dr. Cohen's comments [in Newspaper and magazine clippings, press releases, brochures 2001-2013], 10 September 20119120 Invitation, 10 September 201193 Korean Research Institute of Bioscience and Biotechnology Award of Appreciation, 20 September 201296 Fellow of the American Association for Cancer Research Academy - framed medal and letter, 2013318 DNA Award for Lifetime Achievement - program, 201397 The Biotechnology Innovation Organization and the Chemical Heritage Foundation Eighteenth Annual Biotechnology Heritage Award - plaque, 6 June 201693 Unidentified award - Chinese ink and stamp - "Resolute" on box, undated Memberships Map Drawer 243 Alpha Omega Alpha Honor Medical Society - certificate of membership, 19849121 American Society for Clinical Pharmacology and Therapeutics, 1980-1982Map Drawer 241 American Philosophical Society - certificate of election, 20069122 American Society of Human Genetics, 19859123 American Society for Microbiology (ASM) Search Committee - chair of the Publications Board, 19899124-25 Burroughs Wellcome Fund Experimental Therapeutics Advisory Committee, 1989-1995Map Drawer 243 Institute of Medicine - certificate of membership, 19889126-31 National Academy of Sciences, 1987-1992Map Drawer 242 National Academy of Sciences (NAS) - certificate of membership, 24 April 19799132 National Institutes of Health Alumni Association, 1989-19939133-35 National Research Council - Committee on Biotechnology Nomenclature, 1985-1986921 National Research Council - Committee on Biotechnology Nomenclature (cont'd), 1985-1986922 National Research Council - HHMI Postdoctoral Fellowship Program - evaluation of applications, 1993923 Plasmid Editorial Board, 1977-1979924 Rutgers Cap and Skull - certificate, 10 May 1955925 Sigma Xi, 1978-1993926 The Society of Medical Friends of Wine, 1989-1991927 Thesis committees, undatedMap Drawer 241 American Academy of Arts and Sciences - certificate of membership, 3 May 1978

    Collection Scope and Content Note

    Correspondence, email and electronic records, laboratory notebooks and workpapers, grant files, reports and journal articles, notes, lectures, awards, honors, and memorabilia document the academic and professional career of Stanford University School of Medicine geneticist Stanley N. Cohen. The collection comprehensively covers the many facets of Cohen's career from his early work in artificial intelligence medical diagnosis, his discovery of recombinant DNA technology, the development of laboratory safety standards, the promotion of public knowledge about science, and the ongoing focus of his lab in the areas of plasmid inheritance, cell growth, mobile genetic elements.

    Series 1, Personal and Biographical (1948-2015), illustrates Dr. Cohen's academic achievements as well as his avocations. This includes certificates, diplomas, and yearbooks documenting his professional advancement, along with ephemera relating to his musical and songwriting work and the Society for Medical Friends of Wine. Several folders of clippings (1970-2013) contain articles about Dr. Cohen's career, DNA technology in general, as well as significant items of correspondence. Photographs, correspondence, and website archives for the several Cohen Birthday Symposia celebrate the successes of his lab, colleagues, and staff as well as serve as forums for invitees to discuss and present new areas of research.

    Series 2, Correspondence (1968-2015) is divided into three subseries: chronological files of daily office activity (1977-1996), corporate correspondence (1970-2015), and files by personal name (1968-2011). The series also contains 65 computer discs of correspondence dating from 1979-1986 and email archives dated 1999-2016.

    Series 3, Recombinant DNA (1977-1992) contains a few articles about recombinant DNA along with documentation of the process of the Cogene working group's formulation of guidelines for the safe and ethical use of cloning technology.

    Series 4, Lab Administration (1972-1999) briefly chronicles some of the business and management activities of Cohen's lab. Developing protocols and procedures for the safe handling of biohazardous materials was also a significant outcome of the recombinant DNA work and the Cohen lab administration manual became a model for working safely in the lab and safely conduct experiments. Cohen's work during a sabbatical year to Taiwan University was to establishment a joint biotechnology research venture between Stanford and National Taiwan University (1991-1999) is documented through correspondence and project application files of the Chinese students working in the program.

    Series 5, Lab Notebooks and Workpapers (1963-2010) contains laboratory notebooks, notes, and correspondence produced by researchers in Dr. Cohen's Stanford lab. The lab notebooks contain experiment data; Workpapers is a descriptive term Cohen uses to describe the manuscript drafts and editorial and collaborator correspondence and notes that along with lab data form the final research products. The nine notebooks produced by Dr. Cohen in this series (1963-1967) are representative examples of his postdoctoral research predate his work at Stanford; the lab notebooks for his seminal plasmid DNA work are located in the Smithsonian Museum of American History as are the physical components of the lab and equipment where the work was conducted.

    Series 6, Publication Activity (1959-2016) represents scientific articles authored and co-authored by Dr. Cohen. Numbered articles total 364 but are complete only through the first 200. Those numbered beyond 200 exist variously as drafts, reprints, and correspondence. Many of the later articles exist in this collection only in digital form. This section also contains articles by Dr. Cohen (1959-2001) not represented in the numbered bibliography, and drafts and correspondence for seemingly unpublished articles (1975-1991).

    Series 7, Lectures (1977-2016) consists of correspondence, brochures, announcements, notes, and speeches given by Dr. Cohen at various lectureships, conferences, symposia, and on special occasions. One section is devoted to a particular speech Dr. Cohen developed in response to the general public's reaction to the implications of cloning technology. "Fear of Knowledge" addresses the general phenomenon of fearing knowledge and relates it directly to responses to his work with recombinant DNA and stresses the need to promulgate scientific knowledge as beneficial.

    Series 8, Stanford School of Medicine Genetics Department (1976-2008) contains lecture outlines, lectures, reading lists, readings, examination questions, and syllabi for courses taught by Dr. Cohen at Stanford: Clinical Pharmacology 202, Genetics 201, 202, 208, 209, Pharmacology, other miscellaneous course outlines including graduate medical education material. Dr. Cohen taught medical courses prior to being appointed professor of genetics in 1977 and was department chair.

    Series 9, Contracts and Grants (1967-2010) contain guidelines and reports from various research grants Dr. Cohen's laboratory mostly involving genetic research, but also highlights the other clinical diagnostic fields Cohen worked in especially in the artificial intelligence and computational diagnostic arenas. Among the subjects studied were the evolution of plasmids through the American Cancer Society (1979-1993); ovarian and prostate cancer with the California Cancer Research Program (1998-2003); toxins in mammals and viral pathogens with the Defense Advance Research Projects Agency (DARPA); and genetics, propagation and inheritance of plasmids, genomic DNA cloning and analysis, computer-based online drug therapy monitoring/Mediphor (1970s-1986), computer intervention in clinical drug therapy/Minerva (1977-1983), computational medical diagnosis/MYCIN research with Edward Shortliffe, and tumor suppression gene with NIH (1971-2002). The series also contains an alphabetical list of funding sources.

    Series 10, Material Transfer Agreements (1968-2006) contains records of agreements and transfers made of plasmid DNA strains requested for cloning, documentation of the development of terminology and procedures, and requests for transfers of random homozygous knockout, a mutated gene made to replace a normal genome to study its functions in a live organism.

    Series 11, Cohen/Boyer Patent (1972-2003) contains legal and administrative documents for preparing recombinant DNA patent applications and the subsequent management of royalties and technology usage rights. The materials include legal discussions and debates about the Cohen/Boyer original patent application, technology transfer, royalties, and material usage agreements. It also includes the original patent certificate.

    Series 12, Travel, Meetings, and Seminars (1976-2016), contains brochures, proceedings, agendas, and notes from professional scientific meetings, conferences and symposia Dr. Cohen attended. Among the most frequently attended were meetings with the National Academy of Sciences/PNAS, Gordon research conference, American Society for Microbiology, Institute of Molecular Biology (Taiwan), Federation of American Societies for Experimental Biology, Defense Advanced Research Projects Agency (DARPA), and Singapore Economic Development Board (EDB).

    Series 13, Memberships and Awards (1955-2016), holds certificates, plaques, and artifacts presented to Dr. Cohen. Notable among these are honorary doctorates from Rutgers University and the University of Pennsylvania, the Lasker Award, the Shaw Prize, the Wolf Foundation Prize, the National Medal of Science, the National Medal of Technology, and certificate of induction into the Inventors' Hall of Fame. Certificates and other documentation represent Dr. Cohen's membership in various medical societies and academies.

    Contents List
    Box | Folder Title
     
    Series 1: Personal and Biographical, 1948-2016 [series]:
    1 1
    Rifles for Washington [first prize award for DAR essay contest: 'Atomic Energy - for War or Peace'], 21 June 1948
    1 2-3
    The Periscope of 1952 - Perth Amboy High School yearbook, 1952
    1 4
    United Synagogue Youth Second National Convention program booklet, 1952
    1 5
    Perth Amboy High School Class of 1952 - 35th reunion booklet, 1987
    1 6
    The Nineteen Fifty-Six Scarlet Letter - Rutgers yearbook, 1956
    Map Drawer 24 3
    Rutgers University Bachelor of Arts degree - diploma, 6 June 1956
    1 7
    Scope 1960 - University of Pennsylvania School of Medicine yearbook, 1960
    Map Drawer 24 2
    University of Pennsylvania - diploma, 15 June 1960
    1 8
    University of Pennsylvania Commencement Program, 15 June 1960
    1 9
    "Only You" written by James J. Kriegsmann and Norman Stanton (Stanley N. Cohen) - sheet music, advertising flyer, 1960
    1 10
    Achshav 25th anniversary yearbook, United Synagogue Youth, 1975
    1 11
    "DNA cloning: a personal perspective", by Stanley Cohen, 1988
    1 12
    The Search For Life: Genetic Technology in The Twentieth Century - Smithsonian exhibit pamphlet, 16 December 1987
    2 22
    The Search for Life: Genetic Technology in the Twentieth Century - invitation - [in Newspaper and magazine clippings, press releases, brochures 1983-2001], 10 November 1987
    2 14
    Letter from Stanford President Donald Kennedy [in Newspaper and magazine clippings, press releases, brochures 1978-2004], 30 December 1982
     
    Certificates [subseries]:
    Map Drawer 24 3
    Reserve Corps of the Public Health Service - assistant surgeon appointment, 20 June 1961
    Map Drawer 24 1
    Mount Sinai Hospital - July 1, 1960 to June 30, 1961 internship certification, 30 June 1961
    Map Drawer 24 1
    Reserve Corps of the Public Health Service - senior assistant surgeon certification, 1 July 1962
    Map Drawer 24 1
    License to Practice Medicine and Surgery in the Commonwealth of Pennsylvania, 9 January 1964
    1 13
    National Institute of Arthritis and Metabolic Diseases - certificate of completion of clinical associate duties, 30 June 1964
    Map Drawer 24 1
    North Carolina Board of Medical Examiners - certificate of reciprocity, 24 July 1964
    Map Drawer 24 1
    Duke University Medical Center and Affiliated Hospitals - certificate of completion of senior assistant residency duties, 30 June 1965
    Map Drawer 24 1
    The Department of Professional and Vocational Standards Board of Medical Examiners - certification, 7 October 1968
    Map Drawer 24 3
    Certificate of Appreciation for Acting Chairmanship of SOM Department of Genetics, 1986
     
    Cohen Birthday Symposia [subseries]:
    1 14-15
    60th birthday symposium and celebration [talk, photographs, notes, cards], 1995
    96
    60th birthday - photograph album, 1995
    1 16
    70th birthday, 2005
    1 17
    Biotechnology in the 21st Century: a Scientific Symposium Honoring Stanley N. Cohen - photograph album, 2005
    1 18
    Cohen 75th birthday symposia - "35 years of DNA Cloning", 2010
    1 19
    Cohen 75th birthday symposia - guest book of congratulations, 2010
     
    Business Activities [subseries]:
    1 20
    Cetus and other financial documents, 1976-1981
    1 21
    Medication Services, Inc. - business plan, 1987
    1 27
    New Brunswick Scientific Co., Inc.'s Universal Membrane Filtration Apparatus - brochure [in Newspaper and magazine clippings, press releases, brochures 1970-1978], undated
     
    Society of the Medical Friends of Wine [subseries]:
    1 22
    Wine tasting at the 1987 Miami Winter Symposium - program, 10 February 1987
    1 23
    50th Anniversary - group photograph, January 1989
    1 24
    Tasting of recently released California wines - brochure, 14 November 1990
    1 25
    One Hundred Seventy-Fourth quarterly dinner - brochure, 12 June 1991
     
    Clippings and articles about Dr. Cohen [subseries]:
    1 26
    Wellcome News, Spring 1970
    1 27-29
    Newspaper and magazine clippings, press releases, brochures, 1970-1978
    1 29
    Cathy - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 20 January 1978
    1 29
    Carol Katz - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 20 January 1978
    2 1-3
    Newspaper and magazine clippings, press releases, brochures, 1970-1994
    2 4
    Newsweek, 17 June 1974
    2 5
    Readers Digest, December 1975
    2 6-7
    Magazines and memorabilia, 1975-1979
    2 8
    Atlantic Monthly, February 1977
    2 9
    Time, 18 April 1977
    2 10
    Parents Magazine, November 1977
    2 11
    Stanford Magazine, Fall/Winter 1977
    2 12-14
    Newspaper clippings, letters, news releases, 1978-2004
    2 15
    Newsweek, 17 March 1980
    2 16
    Time, 30 June 1980
    2 17-20
    Magazines and memorabilia, 1980-1990
    2 21
    Scientific American, September 1981
    2 22-23
    Newspaper clippings, magazine articles, 1983-2001
    3 1
    Stanford Medicine, Fall 1984
    3 2
    National Geographic, December 1984
    3 3
    "Le mystique du génie génétique" - by Gilbert Charles, L'Express Aujourd'Hui, 1988
    3 4
    The Life Revolution, a UK Channel 4 television documentary - episode summaries, 1988-1989
    3 5
    "First cloner" - by Lisa Bain, Penn Medicine, Winter 1990-1991
    3 6-8
    Magazines and memorabilia, 1991-2000
    3 9
    Center Focus, Summer 1993
    3 10-11
    Newspaper clippings, brochures, memorabilia [photographs], 1993-1999
    3 12
    Center Focus, Fall 1994
    3 13
    The Pennsylvania Gazette, June 1995
    3 14-16
    Newspaper clippings, brochures, memorabilia [including The Stanley N. Cohen, M.D., Endowed Scholarship update, April 2007], 2001-2013
    3 17-18
    Magazines and memorabilia, 2001-2015
     
    Miscellaneous [subseries]:
    3 19
    In The Genetics Lab at Stanford I, II, and III - artwork signed by Chris Ranes, 1981
    3 20
    Card from Cloris and Herman, 22 August 1981
    3 21
    Letter from congresswoman Anna G. Eshoo to Dr. Cohen re: Stanford Dean's Medal, 26 September 2011
    96
    Framed illustration of design etched in granite on bench panel 09_15 "Recombinant DNA", 2012
    Map Drawer 24 3
    Framed cover of Proc. Natl. Acad. Sci., 3 August 2004
     
    Photographs [subseries]:
    3 22
    Stanley N. Cohen lab bench exhibit - photograph of bench on display at the Smithsonian, 2011 January 5
    3 23
    Stanley Cohen - postdoctoral fellow, 1965
    3 24
    Stan photos - Stanford publicity photos, c.1980s
    3 25
    Lab party at Stan's house, c.1990s
    3 26
    [Dr. Cohen socializing], 1995
    3 27
    To Stan from Phil - trip to Taiwan photos, 17 July 1997
     
    Winding Your Way Through DNA symposium, 25-26 September 1992 [subseries]:
    4 1
    Program booklet
    4 2
    "Stories from the scientists" teacher's guide
     
    Audiovisual [subseries]:
    4
    "New ways of searching for tumor suppressor genes", Stanley N. Cohen; "Molecular markers. . . ", Simon Silver. Wayne State University, Frontiers in Molecular Medicine: Tape 2 - [vhs videocassette], undated
    4
    "Fishing for Genes", Sidney Brenner; "Molecular Markers of Pancreatic Carcinoma and their Clinical Correlations", Vainutis Vaitkevicius. Wayne State University, Frontiers in Molecular Medicine: Tape 3 [vhs videocassette], undated
    4
    Interviews with Watson & Cohen. Danmarks Radio - [2 vhs videocassettes], undated
    4
    "Biotechnology" NHK TV special, Japanese TV [featuring intro by Cohen] - [vhs videocassette], [1998]
    4
    The Life Revolution [documentary series] [6 vhs videocassettes], 1989
    4
    Bernard Cohen Memorial Lecture, Dr. Steven McNight - [vhs videocassette], 19 March 1991
    4
    Our Fragile Fortress - Dr. Stanley Cohen's interview [with thank you note] - [vhs videocassette], 22 April 1994
    4
    Innovative Lives [interactive], Lemelson Center, National Museum of American History, Smithsonian Institution - [cdrom, QuickTime format], 1996
    4
    The Remarkable 20th Century, volume eight: 1970s - [vhs videocassette], 2000
    4
    Eureka! The 20th Century's Top 15 Inventors. A&E Biography - [vhs videocassette], 2002
    4
    Shaw Prize special: Professsor Stanley N. Cohen [biography of Cohen and Boyer discovery] (English and Chinese versions) - [vhs videocassette], 2004
    4
    Sphygmomanometer (blood pressure meter) used by Stanley N. Cohen in medical school at the University of Pennsylvania, 1958-1960
    4
    Electronic records copied from hard drives [3 usb thumb drives]
    Born digital
    Biotechnology Heritage Award [mp4], 2016
    Born digital
    Archive-It web archive, top results for "Stanely N. Cohen" Google search conducted by HMD staff; Stanford Lab website ; Gabriel project; 80th birthday symposium, 2017 [view online]
     
    Series 2: Correspondence, 1968-2016 [series]:
    3 28-29
    Requests: write manuscripts/articles, 1977-1995
    3 30
    Binder #1 - 0002A, 0007, 0105A, 0122A, 0004A, 0011, 0106A, 0006, 0012A, 0107A - [10 8" computer discs], 1979-1985
    3 31
    Binder #2 - 0023A, 0125A, 0129A, 0132A, 0140A, 0143A, 0205A, 0206A, 0213A, 0217A - [10 8" computer discs], 1980-1984
    5 1
    Binder #3 - 0218A, 0225A, 0228A, 0232A, 0220A, 0226A, 0229A, 0221A, 0227A, 0231A - [10 8"computer discs], 1982-1985
    5 2
    Binder #4 - 0002C, 0005C, A2125, 0009C, 0018C, 0003C, 0006C, 0012C, 0004C, 0007C, 0014C - [10 8"computer discs], 1983-1985
    5 3
    Binder #5 - 0234A, 0237A, 0245A, 0235A, 0238A, 0246A, 0236A, 0239A - [8 8" 8computer discs], 1984
    5 4
    Binder #6 - 0011C, 0023C, 0030C, 0015C, 0024C, 0033C, 0022C, 0025C, 0034C - [9 8" computer discs], 1985
    5 5
    Binder #7 - 0016C, 0207A, 0031C, 0137A, 0224A, 0001B, 0141A, 0243A - [8 8"computer discs], 1986
     
    Chron files [subseries]:
    5 6
    4 January-24 May 1977
    5 7
    24 May-29 September 1977
    5 8
    4 October-20 December 1977
    5 9
    8 June-29 September 1978
    5 10
    1 October-15 November 1978
    5 11
    16 November-31 December 1978
    5 12
    1 January-31 March 1979
    5 13
    1 April-12 June 1979
    5 14
    12 June-23 August 1979
    5 15
    4 September-31 December 1979
    5 16
    2 January-7 April 1980
    5 17
    7 April-19 June 1980
    5 18
    19 June-24 September 1980
    5 19
    24 September-31 December 1980
    6 1
    6 January-19 February 1981
    6 2
    19 February-31 March 1981
    6 3
    31 March-9 July 1981
    6 4
    14 July-10 September 1981
    6 5
    11 September-29 December 1981
    6 6
    4 January-29 April 1982
    6 7
    4 May-3 June 1982
    6 8
    8 June-13 August 1982
    6 9
    13 August-31 October 1982
    6 10
    25 October-12 November 1982
    6 11
    4 January-11 April 1983
    6 12
    12 April-31 May 1983
    6 13
    2 June-28 July 1983
    6 14
    1 August-2 December 1983
    6 15
    2-30 December 1983
    6 16
    January-April 1984
    6 17
    May-August 1984
    6 18
    September-December 1984
    6 19
    January-April 1985
    7 1
    May -August 1985
    7 2
    September-December 1985
    7 3
    January-April 1986
    7 4
    May-August 1986
    7 5
    September-December 1986
    7 6
    January-June 1987
    7 7
    July-December 1987
    7 8
    January 1988
    7 9
    February 1988
    7 10
    March 1988
    7 11
    April 1988
    7 12
    May 1988
    7 13
    June 1988
    7 14
    July 1988
    7 15
    August 1988
    7 16
    September 1988
    7 17
    October 1988
    7 18
    November 1988
    7 19
    December 1988
    7 20
    January 1989
    7 21
    February 1989
    7 22
    March 1989
    7 23
    April 1989
    7 24
    May 1989
    7 25
    June 1989
    7 26
    August-December 1989
    7 27
    January-March 1990
    8 1
    April-May 1990
    8 2
    June-July 1990
    8 3
    July-September 1990
    8 4
    October-November 1990
    8 5-6
    January-June 1991
    8 7-8
    July-December 1991
    8 9-10
    January-June 1992
    8 11-13
    July-December 1992
    8 14-16
    January-June 1993
    8 17-19
    July-December 1993
    9 1-2
    1995
    9 3
    4 January-4 April 1996
     
    Corporate Entities [subseries]:
    9 4
    American Broadcasting Company, 1981
    9 5
    Beckman Instruments, 1981-1982
     
    Burroughs Wellcome [subseries]:
    9 6-9
    General, 1970-1988
    9 10
    Interferon shipments, 1979-1981
    9 11-12
    Interferon I, 1979-1980
    9 13
    Scholar Award, 1968-1987
    9 14
    Center for Science in the Public Interest, 1981
     
    Cetus [subseries]:
    2 13
    "Cetus, a genetics engineering firm, plans initial public offer of 5.2 million shares" Wall Street Journal - clipping [in Newspaper clippings, letters, news releases 1978-2004], 14 January 1981
    9 15-16
    Biotechnology Award, 1987-1989
    9 17
    Flukes - Cetus' tenth anniversary issue, April 1982
    9 18
    Ronald E. Cape, 1984-1985
    9 19
    City of Medicine awards, 1996
    9 20
    Committee of Concerned Scientists, Inc., 1984
    9 21
    Czeck affair, 1971-1972
    9 22
    European Scientific Action Group for Nuclear Safety, 1986
    9 23
    Food and Drug Administration (FDA), 1973-1986
    9 24
    Human Gene Mapping Library, 1989-1990
    9 25
    Industrial Biotechnology Assoc., 1987
    9 26
    Life Sciences Foundation - LSF magazine, 2014-2015
    9 27
    Medispan archive, 1991-1995
    9 28
    Meridian Instruments, Inc., 1989
    9 29
    Modern Maturity, 1995
    9 30
    Monsanto, 1987
    9 31
    MSI, 1985-1987
    9 32
    National Research Council Commission on Life Sciences, 1995
    9 33-34
    National Science Foundation, 1985-1990
    9 35
    Nova, 1976-1977
    9 36
    Nuclear disarmament, 1984
    9 37
    Office of Technology Assessment Project (mapping of human genome), 1986-1987
    9 38
    Paid prescriptions, 1971
    9 39
    Robert J. and Claire Pasarow Foundation Medical Research Awards, 1989
    9 40
    People to People Citizen Ambassador programs, 1986
    9 41
    Pfizer, 1977-1982
    9 42
    Promis, 1977
    9 43
    Society for Developmental Biology, 1989
    9 44
    Synthetic oligonucleotides, 1992-1993
    9 45
    Technology transfer, 1989
     
    Individuals [subseries]:
    9 46
    A - General, 1977-1991
    9 47
    Adams, Camellia W., 1987-1993
    10 1
    Adams, Camellia W. (cont'd), 1987-1993
    10 2
    Anderson, E. S., 1969-1976
    10 3
    Andre, Charles P., 1986-1992
    10 4
    Apirion, David, 1991
    10 5
    Axline, Stanton G., 1974-1980
    10 6
    B - General, 1980-1995
    10 7
    Bajorek, Teresa, 1992-1994
    10 8
    Barchas, Jack, 1982-1985
    10 9
    Bastia, Deepak, 1990-1991
    10 10
    Baumler, Ernst, 1981
    10 11
    Beachy, Philip A., 1980
    10 12
    Beale, Dr. John (Burroughs Wellcome), 1979-1980
    10 13-16
    Beatty, J. Thomas, 1979-1996
    10 17-19
    Beaucage, Serge, 1985-1991
    10 20-25
    Belasco, Joel, 1980-1992
    10 26
    Berg, Douglas E., 1981
    10 27-30
    Bibb, Mervyn, 1977-1994
    10 31-35
    Biek, Donald P., 1982-1992
    10 36
    Birnstiel, Max L., 1981-1983
    10 37
    Bjornsson, Thorir, 1972-1978
    11 1-2
    Blair, Deeda, 1986-1990
    11 3-9
    Blaschke, Terry, 1973-1991
    11 10
    Blau, Helen, 1986-1996
    11 11
    Bloomfield, Janine, 1984
    11 12-13
    Blum, Robert, 1976-1986
    11 14
    Bollen, Mathieu, 1995
    11 15
    Boothroyd, John, 1982
    11 16
    Botstein, David, 1979-1996
    11 17
    Boyer, Herbert, 1973-1995
    11 18-19
    Brace, Art, 1981-1993
    11 20-23
    Brasch, Michael [3.5 computer disc], 1986-1996
    11 24-26
    Brenner, Daniel, 1985-1992
    12 1
    Brenner, Daniel (cont'd), 1985-1992
    12 2
    Brevet, Jean, 1972-1983
    12 3
    Briggs, Russ, 1972-1975
    12 4
    Brinton, Charles, 1970-1971
    12 5
    Brothers, Lynda, 1973-1986
    12 6
    Brown, Arnold, 1971-1981
    12 7
    Brown, Byron William, 1976-1990
    12 8
    Brutlag, Simone Manteuil, 1993-1995
    12 9-11
    Bujard, Hermann, 1977-1997
    12 12
    Bush, Diane E., 1976
    12 13-14
    C - General, 1980-1996
    12 15-16
    Cabello, Felipe C., 1996-1998 [1]
    12 17-21
    Calos, Michele, 1981-1987
    12 22
    Cann, Howard, 1978-1984
    12 23
    Carpenter, Karen J., 1985-1991
    12 24
    Carpousis, A. J., 1996
    12 25
    Carrell, Laura, 1990
    12 26-29
    Casabadan, Malcolm, 1975-1988
    12 30
    Case, James, 1980
    12 31
    Caspari, David, 1981-1989
    12 32-33
    Cavalli, Luca, 1978-1990
    12 34-35
    Chang, Poa-Chun, 1990-1995
    13 1
    Chang, Poa-Chun (cont'd), 1990-1995
    13 2-3
    Chang, Shing, 1975-1985
    13 4
    Chang, Wen, 1996
    13 5
    Chao, Chuck, 1990-1996
    13 6
    Chater, Keith, 1983-2000
    13 7
    Chavez-Pardo, Rodolfo [photograph], 1972-1980
    13 8
    Chen, Carton, 1990-1996
    13 9
    Chen, Jianzhu, 1985-1986
    13 10
    Cheng, Te-Fang Delfine, 1985-1988
    13 11
    Chou, Joany, 1975-1993
    13 12
    Choudary, Prahbakara V., 1983-1985
    13 13
    Chretien, Michel, 1979-1993
    13 14
    Chung, Bon-Chu, 1995-1996
    13 15
    Clancy, Suzanne, 1982-1990
    13 16
    Claverie-Martin, Felix, 1995-1996
    13 17
    Clayton, David A., 1970-1996
    13 18
    Clewell, Don, 1985
    13 19
    Cochet, Madeleine, 1978-1981
    13 20
    Cohen, Gerald, 1994-1996
    13 21
    Cohen, Philip, 1995-1996
    13 22-23
    Conley, Dierdre, 1987-1996
    13 24
    Cortese, Riccardo, 1982
    13 25
    Cox, David, 1992
    13 26
    Crater, Dinene, 1996-1997
    13 27
    Cuatrecasas, Pero, 1981-1982
    13 28-29
    D - General, 1979-1996
    13 30
    Davies, Julian, 1991-1998
    13 31
    Davis, Randy, 1973-1977
    13 32
    Delappe, Irving, 1973-1976
    13 33
    Demain, Arnold L., 1980
    13 34
    Donahue, Tom, undated
    13 35
    Doyle, Dierdre [3.5 computer disc], 1986-1999
    13 36
    Driscoll, Janie, 1991-1994
    13 37
    Dubridge, Robert, 1981-1983
    13 38
    E - General, 1982-1990
    13 39
    Erlich, Henry, 1977-1984
    13 40
    Ermakov, Grigory, 1996
    13 41
    Espinosa, Manuel, 1996
    13 42-43
    F - General, 1981-1995
    13 44-46
    Falkow, Stanley, 1977-1989
    13 47
    Federman, Daniel, 1973-1977
    13 48
    Feinberg, Laurie, 1970-1985
    13 49
    Feitelson, Jerald S., 1978-1979
    13 50
    Flaggs, Gail, 1990-1991
    13 51
    Flowers, April, 1987-1988
    13 52
    Fraley, Cres, 1995-1997
    14 1
    Francke, Uta, 1988-1995
    14 2
    Franklin, Rosalind, 1998-1999
    14 3
    Funnell, Barbara, 1994-1995
    14 4-5
    G - General, 1974-1996
    14 6-12
    Gabain (von), Alexander, 1977-1996
    14 13-17
    Gaggero, Christina, 1993-1996
    14 18
    Gallo, Robert, 1986-1988
    14 19
    Ganesan, Adayapalam T., 1978-1991
    14 20
    Gazdar, Adi, 1981
    14 21
    Gelfand, David, 1979
    14 22
    Gershon, Elliot, 1981-1983
    14 23
    Geryk, Donna, 1986-1989
    14 24-31
    Gilbert, David, 1982-1996
    15 1-4
    Gilbert, David (cont'd), 1982-1996
    15 5
    Glazner, Fred, 1981
    15 6
    Gold, Lynn, 1981-1982
    15 7
    Goldstein, Avram, 1980-1988
    15 8-9
    Gossard, Francis, 1980-1988
    15 10-11
    Grant, Sarah, 1981-1994
    15 12
    Grobstein, Clifford, 1977
    15 13
    Gullberg, Martin, 1996
    15 14-16
    Gustaffson, Petter, 1977-1992
    15 17-18
    H - General, 1980-1996
    15 19
    Haase, Steven, 1985
    15 20
    Hackett, Christopher, 1998-1999
    15 21
    Hagedorn, Curt, 1995-1996
    15 22-23
    Hagege, Juliette Martine, 1991-1996
    15 24
    Hakanson, Rolf, 1982-1983
    15 25
    Hamm, Thomas, 1986
    15 26
    Hanawalt, Philip C., undated
    15 27
    Hannigan, John F., Jr., 1973-1977
    15 28
    Hansten, Phil, 1971-1976
    15 29
    Hedges, Robert, 1975-1988
    15 30-31
    Helinski, Donald R., 1975-1995
    15 32
    Hendrich, Brian, 1991
    15 33
    Henning, Karla, 1986-1994
    15 34
    Herbert, Ed, 1980-1982
    15 35-36
    Hernandez, Rachel, 1988-1993
    15 37-38
    Herzenberg, Leonard, 1971-1986
    15 39
    Herzenberg, Leonard (Brenner/Nolan dispute), 1987-1990 [1]
    15 40
    Herzenberg, Leonore, 1980-1987
    15 41
    Ho, Coy Choke, 1980-1993
    15 42
    Hoffman, Barbara, 1996
    15 43-45
    Hoffman-Liebermann, Barbara, 1978-1990
    16 1
    Hogness, David, undated
    16 2
    Hollister, Leo, 1973-1976
    16 3
    Hood, Lee, 1987-1989
    16 4-6
    Hopwood, David, 1994-1996
    16 7
    Hsu, Charles, 1979-1984
    16 8
    Hsu, Leslie, 1971-1972
    16 9
    Huang, Hongjin, 1994-1997
    16 10
    Huang, Huei-Jen Su, 1989-1991
    16 11
    Hunn, Gilbert, 1970-1979
    16 12
    I - General, 1990-1996
    16 13
    Illa, Robert, 1972-1994
    16 14
    Ingmer, Hanne, 1989-1996
    16 15
    Inloes, Doug, 1982-1984
    16 16
    Israel, Alain, 1979-1992
    16 17-18
    J - General, 1982-1995
    16 19
    Jain, Chaitanya, 1995-1996
    16 20-22
    Jaurin, Bengtake, 1980-1988
    16 23
    Jaurin, Kerstin R. V., 1983-1984
    16 24
    Johnson, Jacki, 1981-1984
    16 25
    Johnson, Matti, 1982-1983
    16 26
    Joklik, William K., 1981-1985
    16 27
    Joseph, Loren, 1976-1978
    16 28-29
    K - General, 1980-1996
    16 30-31
    Kaberdin et al., 1994-1996
    16 32
    Kan, Yuet Wai, 1985-1986
    16 33
    Katz, Leonard, 1990-2001
    16 34
    Kaufman, Randal J., 1981
    16 35-36
    Kedes, Larry, 1974-1992
    16 37-38
    Kendall, Kevin, 1983-1996
    16 39
    Kieser, Tobias, 1991
    16 40
    Kim, Eung-Soo, 1993-1996
    17 1-5
    Klug, Gabriele, 1985-1997
    17 6
    Knopf, Ulrich C., 1975-1977
    17 7
    Kondo, Jing, 1984-1985
    17 8-10
    Kopecko, Dennis, 1971-2011
    17 11-16
    Korn, Laurence, 1980-1986
    17 17-18
    Kretschmer, Peter J., 1973-1989
    17 19
    Krysan, Patrick, 1990-1993
    17 20
    Kunst, Frederik (Frank), 1977-1981
    17 21
    Kurth, Janice, 1988
    17 22
    Kwan, Catherine, 1995-1996
    17 23-24
    L - General, 1976-1996
    17 25
    Laird, Alan, 1979-1989
    17 26
    Lander, Eric, 1996
    17 27-28
    Lederberg, Esther, 1973-1978
    18 1-3
    Lederbeg, Joshua, 1976-1993
    18 4-7
    Lee, Stephen, 1984-1991
    18 8-11
    Lemaux, Peggy G., 1976-1991
    18 12
    Levinthal, Elliott, 1978-1984
    18 13
    Levy, Ronald, 1986
    18 14
    Lezhava, Alexander, 1995-1996
    18 15
    Liaw, Yen-Chywan, 1996
    18 16-18
    Liebermann, Danny, 1982-1989
    18 19-22
    Liebermann, Dan and Barbara (Hoffman), 1992-1995
    18 23-26
    Li, Limin, 1989-2001
    18 27
    Lin, Bai Ling, 1997
    18 28-29
    Lin-Chao, Sue, 1986-1996
    19 1-13
    Lin-Chao, Sue (cont'd) [3.5 computer disc], 1986-1996
    19 14
    Linebaugh, Catherine, 1981-1982
    19 15
    Lizardo, Esteban, 1984
    19 16
    Lockwood, Steve, 1979-1980
    19 17
    Losick, Richard, 1984-1989
    19 18
    Lovett, Paul, 1978
    19 19
    Lucio, Simon, 1981-1982
    19 20-21
    M - General, 1978-1997
    19 22
    Machbitz, Jack, 1973-1976
    19 23
    Mackie, George, 1995
    19 24
    Malamy, Michael, 1974-1976
    19 25
    Mandoli, Dina, 1981
    19 26
    Mangini, Richard J., 1975-1984
    19 27
    Mansour, Tag, 1979-1981
    19 28
    Marie, Helene, 1995
    19 29
    Marmur, Mildred, 1991-1992
    19 30
    Marquez, Leticia, 1981-1983
    19 31
    Marrs, Barry, 1976-1982
    19 32
    Masters, Millicent, 1993-1994
    19 33
    Mathews, Kathryn, 1983
    19 34-35
    McClintock, Barbara, 1980-1985
    19 36
    McCoubrey, Annette, 1971-1979
    19 37-42
    McDevitt, Hugh O., 1980-1996
    20 1-3
    McDowall, Kenneth, 1989-1996
    20 4
    McKee, Constance, 1989-1993
    20 5-7
    Meacock, Peter A., 1975-1987
    20 8-11
    Melmon, Kenneth, 1977-2002
    20 12
    Merigan, Thomas E., 1980-1997
    20 13-14
    Michaels, Alan, 1980-1982
    20 15
    Misfeldt, Dayton, 1982-1983
    20 16
    Mitchell, Dorothy, 1985-1993
    20 17
    Mitchell, Rodney, 1985-1986
    20 18
    Miczak, Wei, Lin-Chao, 1995-1996
    20 19
    Mondy, Russell, 1983
    20 20
    Montano, Monty, 1989
    20 21
    Moore, Terrence, 1973-1985
    20 22-23
    Morrell, Joan, 1975-1984
    20 24
    Mortelmans, Kristien, 1984
    20 25
    Murphy, Shari, 1981-1982
    20 26
    Myers, Richard M., 1985-1996
    20 27-28
    N - General, 1981-1996
    20 29
    Nakanishi, Shigatada and Numa, Shosaku, 1978-1982
    20 30
    Narang, Sarah, 1975-1979
    20 31
    Narro, Martha, 1984-1989
    20 32
    Nebert, Daniel W., 1980-1990
    20 33
    Nicolet, Charles, 1984-1987
    20 34
    Nisen, Perry, 1975-1984
    20 35
    Nishimura, Tad, 1972-1973
    20 36
    Noguchi, Toshitada, 1993-1996
    20 37
    Nolan, Garry P., 1984-1988
    20 38
    Nordstrom, Kurt, 1980-1983
    20 39
    Novick, Richard, 1977-1995
    20 40
    Nunberg, Jack H., 1978
    20 41
    O - General, 1976-1992
    20 42
    Ogawa, Joy, 1983
    20 43
    Oishi, Michio, 1995
    20 44
    Oliver, Noelynn, 1981-1982
    20 45
    O'Malley, Karen, 1980
    20 46-48
    Omer, Charles, 1980-1999
    21 1
    O'Reilly, Robert, 1977
    21 2
    Ott, Russell, 1981-1990
    21 3-4
    P - General, 1981-1996
    21 5-6
    Pandza, Kenan, 1995-1996
    21 7
    Pennaccio, Len, 1994-1995
    21 8-10
    Pettis, Gregg, 1988-1996
    21 11
    Phillips, Steve, 1969-1970
    21 12
    Platt, Terry, 1983-1985
    21 13
    Podlone, Michael, 1969-1974
    21 14-15
    Ptaschne, Kay A., 1971-1975
    21 16-17
    R - General, 1979-1996
    21 18
    Rabourdin-Combe, Chantal, 1980-1984
    21 19
    Ramu, Avner [photograph], 1972-1976
    21 20
    Ranes, Monica, 1981-1987
    21 21-22
    Ravnan, Britt, 1983-1993
    21 23
    Regnier, Philippe, 1994-1995
    21 24
    Remington, Jack, 1980-1988
    21 25
    Resnekov, Orna, 1991
    21 26
    Ringold, Gordon, 1977-1982
    21 27
    Risch, Neil, 1993-1994
    21 28
    Robertson, Channing, 1980-1982
    21 29
    Robinson, Harriet, 1980-1996
    21 30-31
    Robinson, W. S., M.D., 1995-1996
    21 32
    Robledo, Basil, 1983
    21 33
    Rogler, Charles E., 1974-1979
    21 34
    Romero, Edward, 1982-1983
    21 35
    Ronquillo, Ricardo, 1983-1984
    21 36
    Rosenstock, Irwin M., 1974-1977
    21 37
    Rothenberg, S. Michael, 1992
    21 38
    Rutherford, Philip C., 1993
    21 39
    Ruvkin, Gary B., 1984-1985
    21 40-41
    S - General, 1982
    22 1
    Sachs, Leo, 1982
    22 2
    Salkinoja-Salonen, Mirja, 1980-1981
    22 3
    Sameshina, Harry, 1981-1982
    22 4
    Schell, Jeff, 1975-1990
    22 5
    Schimke, Robert T., 1978
    22 6-9
    Schottel, Janet L., 1976-1994
    22 10
    Sgaramella, Vittorio, 1976-1991
    22 11
    Shapiro, Lucille, 1988-1996
    22 12
    Sharp, Phillip, 1970-1971
    22 13
    Sharrer, Terry, 1996
    22 14
    Shaw, William V., 1981-1988
    22 15
    Sherratt, David J., 1988-1993
    22 16-17
    Shiffman, Dov, 1988-1995
    22 18-20
    Shortliffe, Edward H., 1971-1990
    22 21
    Siddiqui, Aleem, 1979-1981
    22 22
    Silver, Rich, 1968-1976
    22 23
    Smith, Laurie, 1972-1975
    22 24
    Smith, Mark R., 1995
    22 25
    Smith, William, 1981-1982
    22 26-28
    Sninsky, John J., 1975-1985
    22 29-31
    Spector, David Martens, 1977-1999
    22 32
    Sobottka, Elizabeth, 1982-1984
    22 33-36
    Stein, David, 1981-1993
    22 37
    Steinman, Larry, undated
    22 38
    Stollar, David, 1975-1982
    22 39
    Stuart, Dorsey, 1980-1981
    22 40
    Swanson, Robert, 1998-2001
    22 41
    Sweetser, David, 1991
    22 42
    Szalay, Aladar, 1986
    22 43
    Szybalski, Waclaw, 1980-1996
    23 1-2
    T - General, 1980-1995
    23 3-4
    Tai, Julie Tsu-Ning, 1988-1997
    23 5
    Tatro, David, 1974-1982
    23 6-8
    Taylor, Dean, 1975-1997
    23 9
    Taylor, Sandra, 1982
    23 10-11
    Timmis, Kenneth N., 1972-1984
    23 12
    Tomkins, Lucy S., 1983
    23 13
    Tooze, John, 1980
    23 14-15
    Troutt, Anthony B., 1984-1988
    23 16
    Ts'o, Dr.Paul O. P., 1993-1996
    23 17-19
    Tu, David, 1975-1988
    23 20-21
    Tucker, William T., 1979-1985
    23 22
    U - General, 1973-1991
    23 23-25
    Uhler, Michael D., 1980-1988
    23 26
    V - General, 1971-1986
    23 27
    Van Bree, Mark, 1982-1984
    23 28
    Van Den Berg, David, 1985-1995
    23 29
    Van Embden, J., 1971-1973
    23 30
    Van Zanten, Pamela, 1994
    23 31-32
    Vogtli, Martin, 1987-1994
    23 33
    Vollrath, Doug, 1993
    23 34-35
    W - General, 1980-1996
    23 36
    Wa, Xian, 1996
    23 37
    Wade, Nicholas, 1978-1984
    23 38
    Wagner, Gerhart, 1994
    23 39
    Walker, Daphne K., 1976-1978
    24 1-5
    Wallace, Douglas, 1979-1983
    24 6
    Wang, C. C., 1992-1993
    24 7
    Wang, Fubao, 1992-1996
    24 8
    Wang, Maureen, 1990-1995
    24 9
    Weissman, Sherman, 1981-1983
    24 10
    Westpheling, Janet, 1994
    24 11
    Wheeler, Catherine, 1981
    24 12
    Willetts, Neil, 1981
    24 13
    Wolfsen, Ada R., 1980-1981
    24 14
    Wraith, Sharon, 1975-1979
    24 15
    Wu, Ray, 1978-1999
    24 16-20
    Xu, Feng Feng, 1989-1996
    24 21-22
    Y - General, 1979-1994
    24 23
    Yang-Yen, Hsing-Fang, 1996
    24 24-26
    Yarden, Anat, 1988-1996
    24 27
    Yasuda, Jun, 1996
    24 28
    Yoder, John, 1981-1984
    24 29
    Yosten, Linda, 1973
    24 30
    Yu, Victor, 1974-1978
    24 31-32
    Z - General, 1980-1996
    24 33
    Zabielski, Jan, 1973-1975
    24 34
    Zilinskas, Raymond, 1982
    24 35
    Zweiger, Gary, 1987-1995
    Born digital
    Email archives [21.2 GB], 1999-2016

    Cohen's emails from his sncohen@stanford.edu Stanford account that he sent to/forwarded to and administered by his Administrative Assistant, not those from Cohen's computers and managed by Cohen. These largely represent Cohen's administrative and lab activities, contrasted to the emails he personally managed on his same Stanford account.

     
    Series 3: Recombinant DNA, 1977-1992 [series]:
    1 28
    Stanford University Medical Center News Bureau release of adaptation of Cohen Publication #77: Cohen, S.N. Recombinant DNA: Fact and fiction. Science 195:654-657 [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 14 February 1977
    1 29
    Edward M. Kennedy - letter [in Newspaper and magazine clippings, press releases, brochures 1970-1978], 13 November 1977
    24 36-37
    Cogene - Sagene, 1979-1992
    24 38
    Course on Molecular Genetics, Nairobi, 1985
     
    Working group [subseries]:
    24 39
    Foreign guidelines, 1977-1983
    25 1-4
    Foreign guidelines, 1977-1983
    25 5-6
    Guidelines questionnaire, 1977-1979
    25 7-10
    Guidelines questionnaire - primary responses, 1977-1980
    25 11
    Risk assessment, 1977-1979
    25 12-14
    First report to COGENE from the working group on Recombinant DNA guidelines, 1979-1981
     
    Series 4: Lab Administration, 1972-1999 [series]:
    25 15-18
    Commercial requests RHKO, 1996-2000
    25 19
    Graduate study syllabus, 1979-1986
    1 28
    SNC memo re Ulrich Knopf cloning chloroplast DNA of chlaymdomonas without permission [in Newspaper and magazine clippings, press releases, brochures 1970-1978], July 1976
    25 20
    Protocol for laboratory animals, 1981-1997
    25 21
    Safety, 1979-1992
     
    Cohen Lab Procedure Manual [subseries]:
    25 22-23
    A manual of procedures used in the S. N. Cohen Laboratory, Department of Genetics, Stanford University, March 1988
    25 24-26
    A manual of procedures used in the S. N. Cohen Laboratory [Copy showing changes made], 1988
     
    Equipment manuals and advertising [subseries]:
    26 1
    The Bionet Resource (Bionet satellite program), 1985-1989
    26 2-3
    Densitometer: quick scan R and C SN RID 180108 SP, 1977-1993
    26 4-5
    Electron microscopes, 1972-1981
     
    Stanford-Taiwan Programs [subseries]:
    26 6
    Other Stanford Faculty, 1997
    26 7
    Proposal letter, 1997
    26 8
    Trip funding, 1997
    26 9-13
    Taiwan communications - SND/JD, 1992-1997
    26 14
    Taiwan Institute of Medical Biology (IMB), 1994-1998
    26 15
    Taiwan IMB/NSG proposal, 1993-1994
    26 16
    Taiwan IMB review/recommendations, 1994
    26 17-18
    Taiwan Institute at Stanford, 1991-1992
    26 19-20
    Stanford-National Taiwan University steering committee, 1992; 1995-1998
    26 21
    NTU-Stanford meeting - Taiwan, 2021 October 1997
    26 22
    Brown, Patrick, 1997
    26 23
    Chao, C.K., 1996-1998
    26 24
    Chen, Ding-Shinn, 1997-1998
    26 25
    Greenberg, Harry, 1997-1998
    26 26
    Kierkegaard, Karla, 1997
    26 27
    Lai, Ming-Yang, 1997
    26 28
    Lee, Lin-Shan, 1997
    26 29
    Lin-Chao, Sue, 1996-1998
    26 30
    Mocarski, Edward, 1997-1998
    26 31
    Sarnow, Peter, 1997
    26 32
    Shen, C.-K., 1997
    26 33
    Sung, Mei-Hwa, 1997
    26 34
    Wang, Patrick, 1997-1998
    26 35
    Wu, Cheng-Wen, 1999
    26 36
    Yeh, Shiou-Hwei, 1997
     
    Series 5: Lab Notebooks and Workpapers, 1963-2010 [series]:
     
    Bao, Kai [subseries]:
    26 37
    Notebook files [CD-R], 1999-2004
     
    Lab notebooks [subseries]:
    26 38
    Genetics - 1, 17 June 1998-12 August 1999
    27 1
    Genetics - 2, 14 August 1999-6 February 2001
    27 2
    Genetics - 3, 11 December 2000-12 December 2001
    27 3
    Genetics - 4, 15 December 2001-1 May 2002
    27 4
    Genetics - 5, 8 April-31 December 2002
     
    Bernstein, Jonathan [subseries]:
     
    Notes [subseries]:
    27 5-7
    X-rays, 1989-1999
    27 8
    Notebook files [CD-R], 1996-2002
     
    Lab notebooks [subseries]:
    27 9
    Untitled, 1996
    27 10
    Untitled, 1998-2003
    27 11
    WTof RWE; Smb is WT; Rapid LB time course; B103 backup [5 CD-R, 1 zip disc], 2000-2001
     
    Biek, Donald P. - Notes [subseries]:
    27 12
    par slides, undated
    27 13
    Miscellaneous, undated
    27 14
    Streptomyces transposons, 1983-1984
    27 15-16
    par, 1983-1984
    27 17
    Streptoymces transposons - promoter selections, 1983-1985
    27 18
    Tn10 hops looking for pma mutants, 1984-1985
    27 19
    184 +- par stability, 1984-1986
    27 20
    Effect of rec mutations on pmaA plasmid instability, 1984-1986
    27 21
    pmaA complementation, 1984-1986
    27 22
    Isolation par- point mutants of psc101, 1984-1986
    27 23
    Untitled, 1984-1987
    28 1-3
    pmaB, C (him D, A), 1984-1988
    28 4
    Untitled, 1984-1988
    28 5
    pmaA poster - Gordon conference, 1985
    28 6
    pmaA multimer gels, 1985
    28 7
    Recombination tests in pmaA, 1985
    28 8
    Tn3 transposition in pmaA, 1985
    28 9
    Plasmid studies in rec[ ] -pmaA, 1985
    28 10
    Resolution of plasmid multimers in pmaA (+- Tn3 promoted), 1985
    28 11
    pmaA sectoring and tet dependent sectoring, 1985-1986
    28 12
    Untitled, 1985-1986
    28 13
    psc101 stability studies, 1985-1986
    28 14
    Constructing an SopABC derivative of psc101 par, 1985-1986
    28 15
    Untitled, 1985-1987
    28 16
    Chromosomal mutations affecting psc101 cmp, 1985-1988
    28 17
    pma-10 mini-tet studies, 1985-1988
    28 18-19
    recD paper, 1986
    28 20
    Notes, 1986-1987
    28 21
    Current, 1986-1988
    28 22
    RNase II assays, 1987
    28 23
    Untitled, 1987
    28 24
    rep fusion studies, 1987-1988
    28 25
    Involvement of IHF in the maintenance of plasmid psc101 in E. coli, 1988
    28 26
    Strains put in sc collection by D.B., 1988
    28 27
    Topoisomerase assays, 1988
    28 28-29
    Final versions of IHF papers, 1988-1989
    28 30
    pma-10 studies in progress, 1988-1989
    28 31
    TC promote exps, 1989-1990
    28 32
    or IHF +- par - transformation and stability studies, 1989-1991
    28 33
    REP (alternate gyrate site) studies, 1989-1991
    28 34
    Effect of GUR- on or IHF, 1989-1991
     
    Brasch, Michael A. - Notes [subseries]:
    28 35-36
    SLP1 integration, 1987-1993
    29 1-6
    SLP1 replication, 1987-1993
    29 7
    SLP1 replication, 1993
    29 8-11
    PLJ101 replication, 1990-1991
    29 12-13
    SLP1 1nt and Xis, 1990-1992
    29 14-16
    PLJ101 replication, 1990-1993
    29 17
    PLJ101 replication, 1990-1993
    30 1
    PLJ101 replication (cont'd), 1990-1993
    30 2-4
    Untitled, 1992-1993
     
    Chang, A.C.Y. (Annie) [subseries]:
     
    Lab notebooks [subseries]:
    30 5
    1, 8 November 1976-7 April 1977
    30 6
    2, 7 April-16 August 1977
    30 7
    1, 17 November 1977-7 April 1978
    30 8
    4, 1 December 1977-16 April 1978
    30 9
    5, 16 April-28 July 1978
    30 10
    6, 28 July 1978-5 January 1979
    30 11
    7, 8 January-3 July 1979
    30 12
    8, 3 July-29 November 1979
    30 13
    9, 29 November 1979-29 March 1980
    30 14
    10, 1 April-15 September 1980
    30 15
    11, 15 September 1980-26 January 1981
    30 16
    12, 26 January-6 June 1981
    31 1
    13, 11 June-10 November 1981
    31 2
    14, 10 November 1981-3 March 1982
    31 3
    15, 4 March-19 June 1982
    31 4
    16, 19 June-20 September 1982
    31 5
    17, 21 October 1982-24 March 1983
    31 6
    18, 24 March-30 September 1983
    31 7
    19, 7 October 1983-9 April 1984
    31 8
    20, 10 April-16 November 1984
    31 9
    25, 13 July 1988-17 August 1989
    31 10
    Untitled, 21 August 1989-17August 1990
    31 11
    Untitled, 20 August 1990-21 October 1991
    31 12
    Untitled, 23 October 1991-5 October 1992
    32 1
    Untitled, 10 October 1992-3 May 1994
    32 2
    Untitled, 11 May 1994-6 September 1995
    32 3
    Untitled, 11 September 1995-21 January 1997
    32 4
    Untitled, 23 January 1997-3 June 1998
    32 5
    Untitled, June 1999-March 2000
    32 6
    Untitled, 29 March 2000-22 May 2001
    32 7
    Untitled, 23 May 2001-23 October 2002
    32 8
    Untitled, 24 October 2002-25 March 2004
    32 9
    Untitled, 25 March 2004
    33 1
    Untitled, 25 March 2004
     
    Notes [subseries]:
    33 2-4
    [RNA synthesis, DNA synthesis], July 1969-April 1970
    33 5-6
    [DNA synthesis, B-galactosidase assay, lysozyme assay], May 1970-June 1971
    33 7
    [RNA synthesis], August 1970-July 1971
    33 8-10
    [Burst size, protein synthesis, nuclease activity], January 1971-January 1972
    33 11-12
    [Transformation experiments, isolation of DNA], March-September 1972
    33 13-15
    [Transformation experiments, extraction and isolation of DNA], September 1972-June 1973
    33 16-17
    [Transformation experiments, extraction and isolation of DNA], June-October 1973
    33 18-20
    [RI enzyme, staphy coli plasmid, mitochondrial DNA, xenopus DNA, miscellaneous], December 1973-November 1974
    33 21
    [HIN III, spreading, transformation], December 1974-November 1975
    34 1-2
    [HIN III, spreading, transformation](cont'd), December 1974-November 1975
    34 3
    [DNA extraction, transformation, agarose gel], November 1975-March 1976
    34 4-5
    Protocols and procedures, 1968-1981
    34 6
    Gels, orig. art, 1982
    34 7-8
    Product guides and procedure techniques, 1982-1997
    34 9
    PRSV, PSV2 - DNA, 1983-1990
    34 10
    Notebook files, 1992-1996
    34 11
    Notebook files [2 CD-R], 1997-2006
    34 12-15
    Protocols, 1994-1998
    34 16-17
    Results - ARD, NIPPI [2 3.5 computer discs], 1995-1998
    34 18-20
    Reagent and protocol manual, 1996-2003
    34 21
    Microarray, 1999
    35 1-3
    Gene search vector, 1999-2003
    35 4-6
    HLA-B associated transcript 3 (bat3), 2000-2003
    35 7-8
    Protocol II, 25 April 2003
     
    Cheng, Tzu-Hao (Johnny) [subseries]:
    35 9-11
    X-rays, 2000-2003
     
    Lab notebooks [subseries]:
    35 12
    Genetics - 1, 17 August 2000-15 July 2001
    35 13
    Genetics - 2, 6 July 2001-21 March 2003
     
    Cohen, Stanley N. [subseries]:
     
    Lab Notebooks [subseries]:
    35 14
    Misc. DH, 25 March-6 September 1963
    35 15
    Chloroquine, 20 December 1963-6 March 1964
    35 16
    Polymerase assays, 1963-1964
    35 17
    24 March-29 August 1964
    35 18
    DNA preparations of GSO4 Hg, 29 June-30 August 1965
    35 19
    Data II, 23 September-8 December 1965; 1986
    36 1
    Data 8, 8 May-10 August 1967
    36 2-6
    Taiwan Sabbatical, 1975-1994
    36 7
    The Stan Cohen lab family, 1995
     
    Gilbert, David M. [subseries]:
     
    Notes [subseries]:
    36 8
    Artwork, undated
    36 9-10
    X-ray films, undated
    36 11
    Miscellaneous notes [7.5 computer disc], 1977-1985
    36 12
    5S project II, 1980-1983
    36 13
    Blots - TU, 1983
    36 14
    5S project ex.C II, 1983
    36 15
    5S project I, ex. A, 1983
    36 16
    5S project, ex. D IV, 1984
    36 17
    Replication sorts, 1984-1985
    36 18
    X-ray films, 1984-1985
    36 19
    BPV artwork, 1985
    36 20
    X-ray films, 1985
    36 21-22
    Miscellaneous notes, 1985-1989
    37 1
    MuARS material, 1986-1987
    37 2
    HTC elutriations, 1987
    37 3
    Hamster elutriations, 1987-1988
    37 4
    Figures, 1988
    37 5
    Asilomar, 1988-1989
    37 6
    Lab meeting, February 1989
    37 7
    Lab meeting, 11 August 1989
     
    Lab Notebooks [subseries]:
    37 8
    Cytogenetic studies of replication, 23 March-5 October 1984
    37 9
    Untitled, 17 January 1988-18 September 1989
     
    Ingmer, Hanne [subseries]:
     
    Lab Notebooks [subseries]:
    37 10
    Genetics - 1, 28 October 1989-13 April 1990
    37 11
    Genetics, 20 March-12 December 1990
    37 12
    Genetics, 13 December 1990-3 August 1991
    37 13
    Genetics, 6 August-12 December 1991
    37 14
    Genetics, 15 December 1991-26 May 1992
    37 15
    Genetics, 13 January-17 March 1992
    37 16
    Genetics - 5, 24 May 1992-6 February 1993
    37 17
    Genetics - 6, 11 February-20 July 1993
     
    Notes [subseries]:
    37 18
    Post printing, undated
    37 19
    Scans, undated
    38 1-4
    REPA [2 3.5 computer discs], 1987-1993
    38 5
    General file, 1989
    38 6
    Oligos Hi, 1989-1993
    38 7-8
    Gels, etc. Hi, 1991
    38 9-11
    Clonings Hi, 1991-1993
    38 12-13
    Gels II Hi, 1991-1993
    38 14
    Notebook files, 1991-1998
    38 15
    Gels III Hi, 1993
    38 16
    XLA run, 2 November 1993
    38 17
    XLA run, November-December 1993
    39 1-2
    REPA, 1993
    39 3
    XLA run - REPA, 21-23 September 1993
    39 4-5
    Untitled, July-December 1993
    39 6-7
    SOS, 1994
    39 8
    Untitled, 1994-1995
     
    Kendall, Kevin [subseries]:
    39 9
    Lab notebook file, 1985-1989
    39 10
    Lab notebook, 1985-1986
     
    Lih, Chih-Jian (Jason) [subseries]:
     
    Lab Notebooks [subseries]:
    39 11
    gas7, 1996-2002
    39 12
    DARPA tsg101, 1998-2000
     
    Notes [subseries]:
    39 13
    Sequence gene information, 1996-2000
    39 14
    WI microassay, 2000
    39 15
    Microassay log - exp. record, 2000-2005
    39 16
    txr101, 2000-2003
    39 17
    txr18 BM041, April 2001
    39 18
    3, November 2001
    39 19
    Antibodies - anti-TXR1-1 - peptides - (f)AB-510-4NIK, RNGG, 2001-2006
    40 1
    Yeast 2 hybrid - PIAS I, 2002
    40 2
    txr101 work 4, 2003
    40 3
    Y2B, 2003-2004
    40 4
    txr101 5, September 2003
    40 5
    6, 2004
    40 6
    7, January 2005
    40 7
    Mouse work, 2006
    40 8
    8, January 2006
     
    Lin-Chao, Sue [subseries]:
     
    Lab Notebooks [subseries]:
    40 9
    1, 1987
    40 10
    2, 1988
    40 11
    3, 1988-1989
    40 12
    Works of Daniel/pcr beads, 10 April 1988-15 October 1989
    40 13
    TC-2 and TC-3, 1989-1990
     
    McDowall, Kenneth [subseries]:
     
    Notes [subseries]:
    40 14-15
    Rachel's notes, 1990-1993
    40 16
    Results, 1991-1994
    41 1-2
    Results (cont'd), 1991-1994
    41 3
    Notebook files, 1991-1995
    41 4
    Processed results, 1992-1993
    41 5
    RNase E cleavage of RNAi, 1992-1993
    41 6-7
    Analysis of RNE-1553 and RNE-1825 mutations, 1993-1994
    41 8-9
    General file, 1994-1995
     
    Miller, Christine [subseries]:
     
    Lab Notebooks [subseries]:
    41 10
    Untitled, 1997
    41 11
    Genetics, 1998
    41 12
    PAR, 1999
    41 13
    Genetics, 2000
    42 1
    Genetics, 2001
    42 2
    Genetics, 2002
    42 3
    Genetics, 2003
    42 4
    Genetics, 2004
    42 5
    Genetics, 2005
    42 6
    Genetics, 2006
    43 1
    Genetics, 2007
    43 2
    Genetics, 2008
    43 3
    Genetics, 2009
     
    Notes [subseries]:
    43 4-5
    77, [1967?]
    43 6
    [Episomal DNA], March-October 1968
    43 7-8
    [Sucrose gradients], December 1968-July 1969
    44 1
    RTF, 1969
    44 2-3
    [Model E run, preparative run, sucrose gradients], November 1969-March 1970
    44 4
    [Model E run, sucrose gradients], April-December 1970
    44 5
    RTF, 1971
    44 6-7
    4, 1980
    44 8-9
    Par 1, 1980
    44 10-12
    Par 2, 1982
    44 13-16
    Untitled, 1982-1987
    45 1-2
    Par 3, undated
    45 3-6
    Par 4, 1983
    45 7-9
    Par 5, 1985
    45 10-13
    Par 6, 1986
    45 14-15
    Par 8, 1988
    45 16-17
    Par 9, 1989
    46 1-4
    Par 10, 1990
    46 5-7
    Par 11, 1991
    46 8-11
    Par 12, 1992
    46 12-15
    Par 13, 1993
    46 16-17
    Par 14, 1994
    47 1-4
    Par 15, 1995
    47 5-8
    Par 16, 1996
    47 9-11
    Par 18, undated
    47 12
    PCR quantification, 2010
     
    Qin, Zhongjun [subseries]:
     
    Lab Notebooks [subseries]:
    47 13
    Genetics - I, 8 August 1995-9 April 1996
    48 1
    Genetics - III, 27 February-20 August 1997
    48 2
    Genetics - V, 23 July 1998-16 August 1999
    48 3
    Genetics - VI, 20 August 1999-10 August 2000
    48 4
    Genetics - 7, 12 August 2000-15 March 2001
    48 5
    Genetics - 8, 19 March-18 October 2001
    49 1
    Genetics - 9, 19 October 2001-8 February 2003
    49 2
    Genetics - 10, 8 Feburary 2003-29 October 2004
     
    Notes [subseries]:
    49 3-4
    Lab notebook file, 1995-2003
    49 5
    Untitled, 1996-2005
    49 6-7
    X-rays, 1995-2001
    49 8-9
    [Sequencing], 1996-2003
    49 10-12
    [X-rays], 1997-2003
    49 13
    [Sequencing], 2001-2003
    49 14
    [Reference articles], 2004
     
    Shiffman, Dov [subseries]:
     
    Lab Notebooks [subseries]:
    50 1
    MRNA stability, 13 September 1989-22 March 1990
    50 2
    Untitled, 30 November 1989-12 April 1991
    50 3
    Untitled, 25 October 1990-25 March 1992
    50 4
    Untitled, 8 March-18 June 1992
    50 5
    Untitled, 26 March 1992-23 April 1993
     
    Zhang, Hong [subseries]:
     
    Notes [subseries]:
    50 6
    Senescence - smurf2 - northern, 2000
    50 7
    Senescence - FACS, 2000
    50 8
    Senescence - microarray, 2000-2001
    50 9
    Notebook files [CD-RW], 2000-2007
    50 10
    Senescence - caveolin, 2001
    50 11
    Senescence - h tert, 2001-2004
    50 12
    Untitled, 2001-2006
    50 13
    Senescence - smurf2 - western, 2002
    50 14
    Senescence - smurf2 III, February-August 2003
     
    Lab Notebooks [subseries]:
    50 15
    Untitled, 13 January-12 November 1999
    50 16
    Untitled, 12 March 1999-1 August 2000
    50 17
    Senescence - smurf 2I, November 2000-September 2001
    50 18
    Senescence - smurf 2II, September 2001-February 2002
    51 1
    Senescence - smurf2 - western, 2003
    51 2
    Senescence smurf2 IV, September 2003-May 2004
    51 3
    Senescence - smurf2 - western, 2004
    51 4
    Senescence - smurf2, June 2004-May 2005
    51 5
    Senescence - smurf2, June 2005-January 2006
    51 6
    Untitled lab notebook, undated
    51 7
    [unknown creator] lab notebook Nick translation of pSNAC 38 and pSNAC 5, 7 January-22 April 1981
    51 8
    [Jeff Dangl, MUT, etc.] lab notebook, 14 September 1983-9 March 1987
    51 9-10
    [unknown creator] lab notebooks, 1987-1988
    51 11
    [Gary Zweig/Dave Gilbert] T-Ag control of ori-linked gene expression and loose papers, 1988-1989
    51 12
    [Gene X] lab notebook, 13 September 1989-5 January 1990
    51 13-14
    Peptide [multiple contributors, Annie Chang, Dave Gilbert et al.], 1995-1999
    51 15-16
    Maps-Sequences [microarray sequence data graphs; multiple contributors, Annie Chang et al.], 1996-2002
     
    Series 6: Publication Activity, 1959-2016 [series]:
     
    By Number [subseries]:
    52 1-3
    Bound reprints - #1-200, 1961-1989
    52 4-6
    1 - Comparison of autologous, homologous, and heterologous normal skin grafts in the hamster cheek pouch, 1961
    52 7
    3 - Complex formation between chloroquine and ferrihaemic acid in vitro, and its effect on the antimalarial action of chloroquine, 1964
    52 8
    4 - Spectrophotometric studies of the interaction of chloroquine with deoxyribonucleic acid, 1965
    52 9
    5 - Inhibition of DNA and RNA polymerase reactions by chloroquine, 1965
    52 10
    7 - Specificity of initiation and synthesis of RNA from DNA templates, 1966
    52 11
    8 - Role of DNA in RNA synthesis - XI. Selective transcription of and DNA segments in vitro by RNA polymerase of Escherichia coli, 1967
    52 12
    12 - Genetic transcription in bacteriophage and: Studies of and mRNA synthesis in vivo, 1968
    52 13
    13 - Multiple molecular species of circular R-factor DNA isolated from Escherichia coli - Nature, 1969
    52 14-15
    15 - Non-chromosomal antibiotic resistance in bacteria - II. Molecular nature of R-factors isolated from proteus mirabilis and Escherichia coli, 1970
    52 16
    18 - Isolation of catenated forms of R factor DNA from minicells, 1970
    52 17
    19 - Further studies on the synthesis of RNA in vitro by enzyme-template complexes isolated from induced and lysogens, 1971
    52 18
    20 - Genetic expression in bacteriophage and. IV: Effects of P2 prophage on and inhibition of host synthesis and and gene expression - Virology, 1971
    52 19
    23 - Nonchromosomal antibiotic resistance in bacteria. V: Isolation and characterization of R factor mutants exhibiting temperature-sensitive repression of fertility - J. Bact., 1972
    52 20
    26 - Nonchromosomal antibiotic resistance in bacteria: Genetic transformation of Escherichia coli by R-factor DNA - Proc. Natl. Acad. Sci. USA, 1972
    52 21
    27 - Recircularization and autonomous replication of a sheared R-factor DNA segment in Escherichia coli transformants - Proc. Natl. Acad. Sci. USA, 1973
    52 22
    28 - Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II: Structure of drug resistance (R) factors and F factors - J. Mol. Biol., 1973
    52 23
    32 - Construction of biologically functional bacterial plasmids in vitro - Proc. Natl. Acad. Sci. USA, 1973
    52 24
    33 - Molecular and genetic studies of an R factor system consisting of independent transfer and drug resistance plasmids - J. Bact., 1973
    52 25
    35 - Effects of and development on template specificity of Escherichia coli RNA polymerase - Biochim. Biophys. Acta, 1974
    52 26-27
    36 - A computer-based system for the study and control of drug interactions in hospitalized patients - in Drug Interactions (P.L. Morselli, S. Garattini, S.N. Cohen, eds.), 1974
    52 28
    39 - Replication and expression of Styahylococcus plasmid genes in Escherichia coli - Proc. Natl. Acad. Sci., 1974
    52 29
    40 - Replication and transcription of eukaryotic DNA in Escherichia coli - Proc. Natl. Acad. Sci., 1974
    52 30
    41 - Aryl hydrocarbon hydroxylase induction in mouse peritoneal macrophages and blood-derived human macrophages - Proc. Soc. Exp. Biol. Med., 1974
    52 31
    42 - Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid - J. Bact., 1974
    52 32
    44 - A method for selective cloning of eukaryotic DNA fragments in Escherichia coli by repeated transformation, 1974
    52 33
    45 - Utilization of two distinct modes of replication by a hybrid plasmid constructed in vitro from separate replicons - Proc. Natl. Acad. Sci. USA, 1974
    52 34
    47 - Transformation of Escherichia coli by plasmid chimeras constructed in vitro: A review - in Microbiology-1975 (D. Schlessinger, ed.), 1974
    52 35
    48 - Transformation of Escherichia coli by recombinant plasmid replicons constructed in vitro - in Mechanisms in Recombination (R.F. Grell, ed.), 1974
    52 36
    50 - In vitro construction of bacterial plasmid replicons containing prokaryotic and eukaryotic genes, 1974
    52 37
    51 - Site-specific recA-independent recombination between bacterial plasmids: Involvement of palindromes at the recombinational loci - Proc. Natl. Acad. Sci. USA, 1975
    52 38
    52 - Occurrence of insertion sequence (IS) regions on plasmid deoxyribonucleic acid as direct and inverted nucleotide sequence duplications. - J. Bact., 1975
    52 39
    56 - The manipulation of genes - Sci. Am., 1975
    52 40
    57 - Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coli, 1975
    52 41
    58 - Cloning, isolation, and characterization of replication regions of complex plasmid genes, 1975
    52 42
    59 - Indirect selection of bacterial plasmids lacking identifiable phenotypic properties - J. Bact., 1975
    52 43
    60 - Studies of mouse mitochondrial DNA in Escherichia coli: Structure and function of the eucaryotic-procaryotic chimeric plasmids - Cell, 1975
    52 44
    61 - Replication control in a composite plasmid constructed by in vitro linkage of two distinct replicons, 1976
    52 45
    63 - Structural evolution of bacterial plasmids: Role of translocating genetic elements and DNA sequence insertions- Fed. Proc., 1976
    52 46
    64 - A computer-based approach to the promotion of rational clinical use of antimicrobials, 1976
    52 47
    65 - Uniform nomenclature for bacterial plasmids: A proposal - Bacteriological Reviews, 1976
    52 48
    66 - Gene manipulation - New Eng. J. Med., 1976
    52 49
    69 - Replication region fragments cloned from Flac+ are identical to EcoRI fragment f5 of F, 1976
    52 50
    70 - Involvement of multiple translocating DNA segments and recombinational hotspots in the structural evolution of bacterial plasmids, 1976
    52 51
    72 - Receptivity of physicians in a teaching hospital to a computerized drug interaction monitoring and reporting system - Medical Care, 1977
    52 52
    75 - Selected translocation of plasmid genes: Frequency and regional specificity of translocation of the Tn3 element. - J. Bact., 1977
    52 53
    77 - Recombinant DNA: fact and fiction - Science, 1977
    52 54
    78 - Recombinant DNA: fact and fiction - West. J. Med., 1977
    52 55
    82 - In vivo site-specific genetic recombination promoted by the Eco RI restriction endonuclease. - Proc. Nat. Acad. Sci. USA, 1977
    53 1
    83 - Revised interpretation of the origin of the pSC101 plasmid - J. Bact., 1977
    53 2
    84 - Cloning of Hind III and Eco RI fragments of the R6-5 plasmid by insertional inactivation - in Microbiology (D. Schlesinger, ed.), 1978
    53 3
    88 - Site-specific DNA deletions occurring adjacent to the termini of a transposable ampicillin resistance element (Tn3) - J. Mol. Biol., 1977
    53 4
    89 - Phenotypically cryptic EcoRI endonuclease activity specified by the ColE1 plasmid - Proc. Natl. Acad. Sci. USA, 1978
    53 5
    91 - Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid - J. Bact., 1978
    53 6
    93 - A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments - Cell, 1978
    53 7-8
    97 - Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase - Nature, 1978
    53 9
    99 - Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-[ ]-lipotropin precursor - Proc. Natl. Acad. Sci. USA, 1978
    53 10
    100 - Nucleotide sequence of cloned cDNA for bovine corticotropin-Β-lipotropin precursor - Nature, 1979
    53 11
    106 - Immunological detection and characterization of products translated from cloned DNA fragment - in Methods in Enzymology, vol. 68 (R. Wu, ed.), 1979
    53 12
    109 - Analysis of gene control signals by DNA fusion and cloning in Escherichia coli - J. Mol. Biol., 1980
    53 13
    112 - Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage. In vivo probe for transcriptional control sequences - Proc. Natl. Acad. Sci.USA, 1979
    53 14
    113 - Identification and characterization of a self-regulated repressor of translocation of the Tn3 element - Proc. Natl. Acad. Sci USA, 1980
    53 15
    115 - Transposition protein of Tn3: identification and characterization of an essential repressor-controlled gene product - Nature, 1979
    53 16
    116 - Translocation specificity of the Tn3 element: characterization of sites of multiple insertions - Cell, 1980
    53 17-20
    117 - Transposable genetic elements - Sci. Am., 1980
    53 21
    119 - Initiation of protein synthesis in bacteria at a translational start codon of mammalian cDNA: effects of the preceding nucleotide sequence - Proc. Natl. Acad. Sci USA, 1980
    53 22
    120 - A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces - Nature, 1980
    53 23
    121 - Effect of DNA sequences adjacent to the terminal of Tn3 on sequential translocation - Molec. Gen. Genet., 1980
    53 24
    122 - Structure and genomic organization of the mouse dihydrofolate reductase gene - Cell, 1980
    53 25-27
    123 - Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance - Cell, 1980
    53 28
    124 - 3'-end labeling of DNA with [a-32p] cordycepin 5'-triphosphate - Gene, 1980
    53 29
    125 - Studies of cloned DNA encoding the structure for the bovine corticotropin-Β-lipotropin precursor protein - Ann. N.Y. Acad. Sci., 1980
    53 30-31
    126 - F plasmid provides a function that promotes recA-independent site-specific fusions of pSC101 replicon - Nature, 1980
    53 32
    127 - In vitro gene fusions that join an enzymatically active Β-galactosidase segment of amino-terminal fragments of exogenous proteins: Escherichia coli plasmid vectors for the detection and cloning of translational initiation signals - J. Bact., 1980
    53 33
    128 - Structural organization of human genomic DNA encoding the pro-opionelanocortin peptide - Proc. Natl. Acad. Sci. USA, 1980
    53 34
    131 - Transposition and control - Cold Spring Harbor Symp. Quant. Biol., 1981
    53 35
    132B - Organization of human genomic DNA-encoding pro-opiomelanecortin - in Expression of Eukaryotic Viral and Cellular Genes (Patterson, Kazariainen, Soderlund, Oker-Blom, eds.), 1981
    53 36
    133 - Cloning and expression in Streptomyces lividans of antibiotic resistance genes derived from Escherichia coli - J. Bact., 1981
    54 1
    134 - Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA-termination signal - Proc. Natl. Acad. Sci. USA, 1981
    54 2
    139 - Specialized cloning vectors for hepatitis B virus gene expression in Excherichia coli - Hepatology, 1982
    54 3
    140 - Characterization of the structural gene and putative 5'-regulatory sequences for human proopoimelanocortin - Nature, 1982
    54 4
    144 - Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces lividans - Molec. Gen. Genet., 1982
    54 5
    146 - Decay of mRNA in Escherichia coli: Investigation of the fate of specific segments of transcripts - Proc. Natl. Acad. Sci. USA, 1983
    54 6
    149 - Hybridization of cloned Rhodopseudomonas capsulata photosynthesis genes with DNA from other photosynthetic bacteria - J. Bact., 1983
    54 7
    150 - Ethanol production by saccharomyces cerevisiae immobilized in hollow-fiber membrane bioreactor, 1983
    54 8-10
    151 - Nucleotide sequence of the partition locus of Escherichia coli plasmid PSC101 - Gene, 1983
    54 11
    154 - Hollow-fiber membrane bioreactors using immobilized E. coli for protein synthesis - Biotechnology and Bioengineering, 1983
    54 12
    155 - Streptomyces lividans RNA polymerase recognizes and uses Escherichia coli transcriptional signals - Gene, 1984
    54 13
    156 - Effects of alterations in the translation control region on bacterial gene expression: use of cat gene constructs transcribed from the lac promoter as a model system - Gene, 1984
    54 14-16
    157 - Structural and functional analysis of the par region of the pSC101 plasmid - Cell, 1984
    54 17
    158 - Plasmid formation in Streptomyces: excision and integration of the SLP1 replicon at a specific chromosomal site - Molec. Gen. Genet., 1984
    54 18
    159 - Growth-rate dependent regulation of mRNA stability in Escherichia coli - Nature, 1984
    54 19-20
    160 - Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic-rxcA transcript - Cell, 1985
    54 21
    161 - Partitioning of the PSC101 plasmic during cell division - in Plasmids in Bacteria (D. R. Helsinki, S. N. Cohen, D. B. Clewell, D. A. Jackson, A. Hollander, eds.), 1985
    54 22
    162 - DNA cloning: historical perspectives - in Biogenetics of Neurohomonal Peptides (Ferring Symposium 1983; R. Hakanson, J. Thorell, eds.), 1985
    54 23
    163 - Structural analysis of the gene encoding human proopiomelanocortin - in Biogenetics of Neurohormonal Peptides (Ferring Symposium 1983; R. Hakanson, J. Thorell, eds.), 1985
    54 24-26
    164 - TU elements: a heterogeneous family of modularly structured eucaryotic transposons - Mol. Cell. Biol., 1985
    54 27-28
    165 - SLP1: transmissible streptomyces chromosomal element capable of site-specific integration, excision, and autonomous replication - in Microbiology (Proceedings of the Third American Society for Microbiology Conference; C. L. Hershberger, ed.), 1985
    54 29
    166 - Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces - Molec. Gen. Genet., 1985
    54 30-33
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