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National Library of Medicine

Finding Aid to the Thomas C. Chalmers Papers1927-1995

Archives and Modern Manuscripts Program, History of Medicine Division
Processed by Daniel J. Lavoie II
Processing Completed May 2004
Encoded by Daniel J. Lavoie II and John P. Rees


Summary Information
Title: Thomas C. Chalmers Papers
Creator: Chalmers, Thomas C. (Thomas Clark), 1917-
Dates: 1927-1995
Extent: 32.35 linear feet (50 boxes)
Abstract:
Thomas C. Chalmers, MD, clinician- scientist- teacher- administrator- entrepreneur, played a pivotal role in the scientific development of the randomized control trial and clinical trial meta-analysis. Research files, teaching materials, correspondence, publications, conference packets and notes, audiovisuals, and personal material document his life and medical career.

Call number: MS C 542
Language: Collection materials primarily in English
Location: Materials stored onsite. History of Medicine Division. National Library of Medicine

Access Restrictions:

Portions of the collection are restricted according to HMD's Access to Health Information of Individuals policy. Contact the Reference Staff for information regarding access. For access to the policy and application form, please visit https://www.nlm.nih.gov/hmd/manuscripts/phi.pdf.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Chalmers, Thomas C. Thomas C. Chalmers Papers. 1927-1995. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 542.

Provenance:

Gift, Thomas C. Chalmers Centre for Systematic Reviews, 10/19/2000. Acc #2000-48.


chalmers542Finding Aid to the Thomas C. Chalmers Papers, 1927-1995Archives and Modern Manuscripts Program, History of Medicine Division1.0History of Medicine Division, National Library of Medicine.
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Machine-readable finding aid encoded by Daniel J. Lavoie IIFinding aid is written in EnglishMarch 23, 2004PUBLIC "-//National Library of Medicine::History of Medicine Division//TEXT (US::DNLM::MS C 542::Thomas C. Chalmers Papers)//EN" "chalmers542" converted from EAD 1.0 to 2002 by v1to02.xsl (sy2003-10-15).

National Library of Medicine

Finding Aid to the Thomas C. Chalmers Papers1927-1995

Archives and Modern Manuscripts Program, History of Medicine Division
Processed by Daniel J. Lavoie II
Processing Completed May 2004
Encoded by Daniel J. Lavoie II and John P. Rees

Descriptive Summary

Chalmers, Thomas C. (Thomas Clark), 1917-Thomas C. Chalmers Papers Dates: 1927-199532.35 linear feet (50 boxes)MS C 542 Materials stored onsite. History of Medicine Division. National Library of Medicine Collection materials primarily in EnglishAbstract:Thomas C. Chalmers, MD, clinician- scientist- teacher- administrator- entrepreneur, played a pivotal role in the scientific development of the randomized control trial and clinical trial meta-analysis. Research files, teaching materials, correspondence, publications, conference packets and notes, audiovisuals, and personal material document his life and medical career.Provenance:

Gift, Thomas C. Chalmers Centre for Systematic Reviews, 10/19/2000. Acc #2000-48.

Access Restrictions:

Portions of the collection are restricted according to HMD's Access to Health Information of Individuals policy. Contact the Reference Staff for information regarding access. For access to the policy and application form, please visit https://www.nlm.nih.gov/hmd/manuscripts/phi.pdf.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Chalmers, Thomas C. Thomas C. Chalmers Papers. 1927-1995. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 542.

Biographical Note

Thomas C. Chalmers, MD, clinician- scientist- teacher- administrator- entrepreneur, was born in Forest Hills, New York, on December 8, 1917 and played a pivotal role in the scientific development of the randomized control trial and clinical trial meta-analysis. He attended Yale College from 1936 to 1939 as an English major and received his M.D. degree from the College of Physicians and Surgeons, Columbia University in 1943. He spent the following year interning in medicine at Presbyterian Hospital in New York City and completed his residency in 1947 at Harvard Medical Services of the Boston City Hospital.

Over the next six years he served as a part-time physician of the Thorndike Memorial Laboratory while practicing medicine in Cambridge, Massachusetts. In 1951 he was the principal investigator of the hepatitis treatment research unit of Harvard Medical School in Kyoto, Japan, and his military service was spent doing research as a member of the metabolic unit of the Army Medical Services Graduate School at Walter Reed Medical Center in Washington D.C. From 1955 to 1968 he was Chief of the Medical Services of the Lemuel Shattuck Hospital in Boston and Professor of Medicine at Tufts Medical School, and lecturer at Harvard.

In 1968 Chalmers became head of the research and education program of the Veterans Administration in Washington, D.C. After 18 months, he was appointed Associate Director for Clinical Care and Director of the Clinical Center of the National Institutes of Health until 1973. During these same years he also served as Professor of Medicine at George Washington University School of Medicine also in Washington, D.C.

After his tenure at NIH, he became President, Dean, and Professor of the Mount Sinai Medical Center and School of Medicine until 1983. During his time at Mount Sinai he created and developed both the Biomathamatical Sciences and the Geriatrics and Adult Development departments.

During the latter half of the 1980s he served as Distinguished Physician at the Boston Veterans Administration Medical Center. In addition, he was also a lecturer at the Harvard School of Public Health, in Epidemiology at Boston University School of Medicine, and in Medicine at Tufts University School of Medicine.

In 1993 he co-founded MetaWorks, Inc. with Susan Ross, M. D. and served as chairman of the company until his death in 1995. Metaworks, Inc. provides evidence-based medical information and is a designated Evidence-Based Practice Center. MetaWorks specializes in acquiring, synthesizing, analyzing, interpreting and delivering medical information in a way that transforms it from raw data into meaningful, actionable evidence. Chalmers' expertise was instrumental in the training of the MetaWorks scientific team, and in establishing the systems and practice standards by which MetaWorks' methods and procedures are governed.

Chalmers held memberships in a number of professional societies, including the Association of American Physicians; the American Association for the Study of Liver Disease, of which he was president in 1959; the American Gastroenterological Association, of which he was president in 1969; and the American Society for Clinical Investigation. He was a fellow of the American College of Physicians and a member of the Institute of Medicine of the National Academy of Sciences.

Chalmers also served on review committees and advisory boards of governmental and national professional bodies, including the National Cancer Institute, National Heart and Lung Institute, National Institute of Arthritis, Metabolism, and Digestive Disease, the Food and Drug Administration, and the National Research Council.

His research interests included the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology, and geriatrics. Chalmers realized earlier in his career that many of the treatments he was taught had been disproved by clinical trials. This ultimately changed his views on medicine and led him to pioneer and promote meta-analysis during the latter half of his career through his medical practice, research, and professorial positions. He also advocated the randomized assignment of patients in studies to avoid bias in the selection of treatment. Through his studies of randomized control trials Chalmers proved that had the trials been systematically and cumulatively synthesized, important treatments such as thrombolytic therapy for myocardial infarction would have been recognized much earlier. In addition, he also demonstrated that the advice given in textbooks and reviews articles did not correspond to the current available evidence when published.


Research files, teaching materials, correspondence, publications, conference packets and notes, audiovisuals, and personal material (1951-1995; 29 linear feet) document the life and medical career of Thomas C. Chalmers. Materials cover his career from Harvard Medical School to his final work with MetaWorks, Inc. The majority of the collection consists of subject files containing reports, articles, correspondence, and notes concerning his research interest in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. There also exists a small percentage of teaching materials in the subject files from Chalmers' various positions as lecturer and professor of medicine. The bulk of the collection spans the years 1951-1953 and 1970-1995.

The collection is organized into 6 series: Personal and Biographical; Subject Files; Hepatitis Study, Kyoto, Japan; Publications; Conferences; and Audiotapes.

Of significant interest in Series 4: Subject Files, is the material in the Linus Pauling and Vitamin C folders which contain information on Chalmers' debate with Pauling over the efficacy of Vitamin C as a cure for the common cold. These folders include debate transcripts, correspondence, and articles. Also of interest in this series is the MetaWorks Business Plan, 1993. This file folder includes correspondence and a 1993 summary of events relating to the company's inception. In addition, Series 5: Hepatitis Study, Kyoto, Japan is also significant for its documentation of Chalmers' 1951 to 1953 hepatitis study. Chalmers later used this study to disprove the common belief that long periods of bed rest were beneficial to those suffering from acute infectious hepatitis. This series includes correspondence, reports, charts, and other data relating to this study.

Index Terms

These terms are indexed in the National Library of Medicine's online catalog LocatorPlus. Researchers wishing to find related materials should search the catalog using these terms.

    MeSH Subjects

    • Cardiology
    • Clinical Trials
    • Evidence-Based Medicine
    • Gastroenterology
    • Geriatrics
    • Hepatitis
    • Meta-Analysis
    Corporate Names

    • Boston City Hospital
    • George Washington University. School of Medicine
    • Harvard Medical School
    • MetaWorks, Inc
    • Mount Auburn Hospital
    • Mount Sinai School of Medicine
    • National Institute of Health (U.S.)
    • New England Center Hospital
    • United States. Veterans Administration
    • Walter Reed Army Hospital (Washington, D.C.)
    Series 1: Personal and Biographical, 1954-1995
    This series contains correspondence, notes, and reunion materials relating to Dr. Chalmers' family and personal life. On August 31, 1942, he married his wife Frankie Talcott with whom he had four children. This series includes correspondence with his wife and son Richard, as well as general family letters which detail some of Chalmers' trips abroad. In addition, Chalmers' Philips Exeter Academy Class of 1936 50th Reunion materials are also included in this series. The series is arranged alphabetically by file folder.

    11 Boston City Hospital Retirement, 1954-196912 Compositions and Poems, 198313 Continuing Medical Education, AMA, MSSN, 1974-198514-6 Correspondence, 1973-199517-9 Correspondence, Family, 1970-1990110 Correspondence, Family and Related Materials: China, 1983111-12 Exeter Reunion, 1984-1986113 Mount Sinai Contract Issues, 1975-1983114 Position Appointments and Benefits, 1967-1972 Series 2: Subject Files, 1927-1995
    This series contains publications, drafts, reports, charts, and notes concerning Chalmers' research interests in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. A small percentage of Chalmers' teaching materials that include teaching plans and syllabi can also be found in this series. The series is arranged alphabetically by file folder.

    115 2nd Batch of Blinded Prostate Papers, 1977-199221 2nd Batch of Blinded Prostate Papers (cont'd)22 4 Randomized Control Trials to Show Corticosteroids, 1981-198623 5 AIDs Papers to Score for Paolo, 1989-199324-7 A. 166, 1986-198728 A Biological Consideration of Treatment of Breast Cancer, 196929 Abdominal Hysterectomy, 1972-1988210 Abstracts: Gastro bleeding, ulcers, 1957-1992211 Ace Inhibitors All Study, 1992-1995212 Acute Cystitis, 1984-1985213 Acute Cystitis/Urinary Tract Infection, 1984-1985214 Acute Myocardial Infarction Slides215 Acute Myocardial Infractions Helpers, 199131 Adjuvant Breast Cancer: Rx-Update, 1984-198632 Adjuvant Chemotherapy for Breast Cancer Update, 198633 Advanced Cancer, 198334 Age: Distribution of Meta-analyses35 Bones and Joints, 1988-198936 References, Neuropsychology, 1988 Agency for Health Care Policy and Research37 Contract, 1990-199138 Renewal, 199039 Agenda Planning Diary, 1991310 Agendas, 1991311 Agendas I, 1991 Aging312 Section C, 1966-1988313 Society, 1987-1988314 Work, 1988-1990315 AIDs316-19 AIDs Immunology, 1976-198741 "Air Traffic Controller Health Change Study", 197842 Alpha I and Hypertension, Meta-analysis and Lipids, 198643 AMA Meta-analysis, 1983-198544-5 Amoxicillin Therapy, 1982-198546 Analytic Procedures, 195547 Angiography: Cholesterol, Good, 1978-199048 Ankle Fracture Fixture, 198749 Anti-arrhythmic Drugs410 Antibiotic/Accepted Articles: Colon Surgery, 1981-1989411-12 Antibiotic Hysterectomy, 1965-199251 Antibiotic Prophylactic, 1988-199152 Antibiotic Prophylactics in Surgery, 1973-199253 Antibiotic Rejected Articles, 1984-198954 Antibody E5, 1991-199255 Anti-inflammatory Drug Study, 198756 Apheresis Manuscript, 198057 Apheresis Randomized Control Trials, 1979-198358 Appendix: Report of the Secretary's Commission on Medical Malpractice59 Appropriateness Research, 1987 Articles510-121955-197861-111967-198971-81970-199581-91983-1995911970-197492 Articles and Correspondence, 199393 Aircraft Accidents, 1974-198294 Clinical Trial, 197995 For Thomas C. Chalmers's Editorial, 1987-198896 Rejected for Gastrointestinal Hemorrhage Paper, 1937-195897 Rejected for Hemorrhage Paper, 1937-195898-9 Used for Gastrointestinal Hemorrhage Papers, 1942-1965910 Ascorbic Acid, 1971-1977911 Ascorbic Acid: National Institute of Health Study [slides], 1973912-13 Aspirin Papers (Joe Cappelleri), 1974-1991101-2 Asthma/Oral Drugs Back 85: Aspirin Dose Study, 1992103 Atherosclerosis, 1951-1979104-5 Autopsy Reprints Errors, 1953-1989106 Aviation Accidents, 1980-1983107-8 Bachrach, N., 1983-1989109 Background, 1995111 Batch 1: Peptic Ulcer Papers, 1979-1990112 Batch 2: Peptic Ulcer Papers, 1981-1989113 Berlin's, Dr.: Comments, 1995114-6 Beta Blockers, 1993117 Beta Data and Charts, 1978-1989118-10 Beta Papers, 1988-19891111 Bias Paper, 19821112 Big vs. Small1113 Biography and Schedules1114 Bleeding Peptic Ulcer, 1986-19911115 Bleeding Ulcers, 1989-19921116 Blocking Agents, 1993-19941117 Blue Book Update: Beta, 1987-19881118 Blum File, 19871119-20 Blum, Almanac, Dec. 7, 19871121 Books on Errors, 19831122 Boston City Hospital, Out-Patient Department, 1952-19541123-24 Boston Meta-analysis Candidate, 1986-19871125 Breast Cancer Article, 1986-19871126 Breast Cancer Med '86, 19911127 Breast Cancer Screening, 1987-19921128 Breast Cancer-Reject Papers, 19861129-30 Brian, 19901131 Brookline Ashes, 19871132 Burns, 1978-19871133 Burrows Study, 19891134 Buyse, Mark, 19841135 Buyse, Mark: Gastric Cancer, 1977-19841136-37 CA B6 Meta-analysis for POARP, 1989-19911138 CABG Overheads1139 CABG Summaries1140 Cabin Air Quality, 19881141 Cabin Air Quality Slides1142 Caesarean, 19931143 Caesarean Charts, 1972-19891144 Caesarean Section, 19901145 Caesarean Section Antibiotics121-3 Caffeine Study, 1952-1983124-6 Calendars, 1987-1990127-8Cancer Articles, 1984-1986129Cancer Papers, 1977-1989131-2Cancer Papers (cont'd.)133Cancer Therapy, 1977-1992134 Cardiology, 1994135 Carlisle, Paul and Tony Singletary [burn victim slides], 1969-1981136 Carotid Surgery, Hefan, 1985137 CCB Overheads138-9 Celiac Plexus Block Papers, 1972-19921310-11 Chalmers, Iain, 1985-19881312 Chapman and Hall, 1992-19951313 Chapter on History of Clinical Trials, 1986-19911314 Charts, 1986-19931315 CHD Hormones, 1963-19791316 CHD: ICCU, 1971-1979141 Cholesterol and Stroke, 1992-1993142 Cholesterol: Lowering Meta-analyses, 1974-1992143 Chronic Effects of Tolbutamide, 1972-1974144 Ciguatera145 Clinical and Clim Paper Gastrointestinal Hemorrhage, n.d146 Clinical Pharmacology in Aged, 1984147 Clinical Pharmacology in the Elderly, 1989 Clinical Trials148-9 Clinical Trials, 1975-19881410 Travel time experiment, 1977-19821411 Grant on Technical Evolution of Literature, 19821412-13 Clippings, 1978-19821414 Clozapin Therapy for Schizophrenia, 19911415 Coffee Trial, 19831416 Cognitive Behavior Eisenberg, 1991151 Colon Adjuvant, Recent Publication, 1985152 Colon Cancer, 1971-1976153 Comparison of Methods, 1992154 Completed Forms, 1950-1976155-6 Completed Hysterectomy Master Copies, 1973-1990157 Computer Ethics, 1973-1976158 Controlled Clinical Trials, 1974159 Controlled Study Articles, 1983-19911510-12 Controlled Therapeutic Trials, 1970-19941513 Cook and Tryba Meta-Analysis, 1979-1991161 Cook and Tryba Meta-Analysis (cont'd.) Correspondence1621971163-519731661974-19841671985-19861681990-19921691993-19941610 Correspondence and Meta-analysis, 19951611-12 Correspondence and Papers, 1990-19941613 Course: Meta-analysis, 19861614 Course: Case Control Etc., 19841615 Crohn's Scores: Meta-analysis, 1979-19841616 Crohn's, 19921617 Cumulative Meta-Analysis, 19941618 Cumulative Meta-Analysis: Marubini Talk in Paris, 19891619 Cumulative Rearrangements, 1976-19881620 Current Clinical Trials, 1994 CVS1621 Acute Myocardial Infractions, 19831622 Angina Pectoris, 19711623 Arteriosclerosis, 1970-1979171 CABG, 1982-1983172 Cineangiograph, 1979-1982173 Coronary Reperfusion, 1982174 Epidemiology, 1980-1983175 Hemostosis, 1980-1981176 Lipids Cholesterol, 1979-1980177 Pharmacology, 1979-1980178 Stroke, 1983179 Type A Behavior, 19831710 DA Grant, 19891711 Data1712 Data and Summary of Levamisole, 1980-1990181 Data and Summary of Levamisole (cont'd.)182 Data(2): Hormonal Influence for Iron Absorption, 1959183 Delays, 1985-1991184 Delphi-1, n.d185-6 Depression, 1988-1992187 DHMC, 1993188-9 Diabetes, 1984-19911810 Diabetes Survey, 1988-19911811-13 Diagnostic Errors, 1951-1988191 Diet, Heart, Review, 1984192 Digestive Diseases Grant, 1989193 Dipyridamole, 1990194 Dipyridamole Thallium, 1982-1986195 Double-Blind Study, 1965196 Drug Abuse, 1991197-8 Drug Abuse Grant, 1989199 Early PTCA, 19941910 ECRI Meta-analysis, 19941911 Edited Draft of "The Efficacy of Medical Treatments on Peripheral Diabetic Neuropathy...", 19931912 Effective Care in Pregnancy and Childbirth: Hormones (Iain Chalmers), 1978-19861913 Eisenberg #1 to Blind, 1990-19911914 Eisenberg Papers, 19931915 Eisenberg Papers for Thomas C. Chalmers, 1976-19931916 Electronic Journal of Meta-analysis, 19841917 Endoscopic Rx Hemorrhage1918 Epidemiologic Meta-analysis Overheads1919 Epidemiologic Survey, 1986 Errors19201986-19891921 Airplane, 1974-19821922 Anesthesia, 1972-19831923-24 Background Reading, 1981-19831925 Clinicopathological Conferences, 19821926 Current, 19831927 Dates on Intensive Care Units, 19881928 Manuscript, 19831929 Manuscript II, 19831930 March '84, 1983-19841931 Medication, 19891932-33 More, 1954-19831934 Notes, 1981-19831935 Relating Tourniquets, 19801936 Reprints, 1981-19831937 Ethics of Randomized Clinical Trials, 19911938 Ethics Slides, 1972-19921939 Etiology of Duodenitis, 1964-19771940-41 Excluded, 1974-19831942 Exercise, 19881943 Expert Forms, 19911944 Extra Applications, 1982-19861945 Fawzi, Wafaie W., 1990-19931946 Faxes, 1988-19891947 Felson Study, 19911948 Fibrinolytic Side Effects1949 Fibrinolytic Therapy Graphs, 19891950 Final Graphs for Chlor1951 Financial Data1952 Flouty: Nifedipine, 1995201 Folati and Malformation, 1993202-3 Forgotten Research, 1979-1991204 Forms and Worksheets, Meta-analysis, 1984-1985205 Foundations, 1987-1988206 Foundations: Iain Chalmers, 1987-1988207-8 FTC209 Furberg Press Releases, 1995 Gail's Papers20101978-19832011 Perfect References, 1983-19842012-13 Project #2, 1976-19832014-21 Study: Included, 1964-19832022-23 Study: Jaundice, 1978-19802024 Gamma Globulin in Post-transfusion Hep., 1977-19782025 Gastric Freezing, 19642026 Gastric Ulcers, 19902027-28 Gastroenterology International, 1988-19892029 Gastrointestinal Bleeding Articles, 1979-1989 Gastrointestinal Hemorrhage2030 Gastrointestinal Hemorrhage, 19902031 Collins (Studies in References), 1987-19922032 10 and Hem. 11- Full Papers for Thomas C. Chalmers, 1983-19892033-34 Data, 1927-19692035 Log, 1985-1989211 Meta-analysis Update File, 1971, 1990212 Review and Thomas C. Chalmers, 1975-1987213 Review Articles, 1981214 Gastrointestinal Meta-analyses215 Gastrointestinal New Rejects, 1990-1991216 Gastroplasty, 1994217 Genealogy, 1961-1962218 Geneval, 1994219 Geriatric Randomized Control Trials, 1988-19892110 Good Peptics 60's, 1967-19702111 Gray Gray, Darryl2112-131961-19872114 Burn Excision, 1984-19862115 E.G. Work Records Protocol, 19862116 Front Sheets, 1976-19852117 Greenlaw 7/5/93, 1990-19932118 Grey Scores, 19852119 Halothane: Ris/Case/Cohort Study Cur. Con., 1966-1986 Harvard School of Public Health21201985-19862121 11/13, 1974-19862122 Course, Bias, Sackett, 19842123 Course, Illness Requiring Clinical Trials, 1981-19822124 Office, 19892125 Health Care Crisis2126 Health Care Crisis Paper2127 Health Effects, 19912128 Helicobater, 19932129 Hemorrhage Reference, 1981-19892130 Hepatitis, n.d2131 Hepatogastroenterology, 1988-19902132 Home2133 Home Randomized Control Trials, 1981-19822134 Home Research, 19812135-36 Hospice Care, 1978-19842137 Hyperbili Data, 1982-1986 Hypertension2138-3919882140-41 During Pregnancy, 1969-19852142 In Aged, 1990-19932143 Lovell, 1981-19922144-45 Meta-analysis, 1983-19922146-47 Papers, 1973-19932148-50 Study2151 Tables, 19932152 Treatment2153 Research, 19862154-55 Hypokaliemia and Q.T. Problems, 1982-1989221 Iatrogenic Disease, 1955-1980222-3 Iloprost, 1989-1990224 Immunoterapia Advante, 1976-1986225 Impact on Practices, 1991226 Impact on Prostate227 Important Squam Information: Frank Mason, 1983-1984228 Infectious Diseases and Gastroenterology Publications, 1990-1991229 Informed Consent, 1966-19832210 Intermittent Claudication other Drugs, 1984-19872211 Intracranial Hemorrhage, 1983-19862212 Ischemia and Serotonin, 19882213 ISI Slides, 19892214 ISIS II, 19882215 ISIS, 4 Overheads2216 Jacquotte, Anne Papers for Scoring, 1959-19852217 Janssen Grant, 1988-19912218 Janssen Pharmaceutica, 19892219-20 Jenny Rejects, 1987-19882221 Job Seekers [Dr. Chalmers], 1966-19732222 Jokes Jovell, Albert J.2223-251990-19922226 OJCC [Slides, Transparencies, Photographs] Kannry, Joe2227-291988-19892230 Abstracts, 1988-19892231 Papers2232-37 Project Papers, 1961-1986 Ketanserin2238 Add, on Trials, 1987-19882239 Comparison with other Drugs, 1986-19892240 Hypertension2241 Intermittent Claudication, 1984-19892242 Mechanism, 1983-1989231-2 Mechanism, 1983-1989233 New Reject Anti-Hypertension, 1987-1988234 Placebo Hypertension, 1981-1987235 Short, Meta, 1985-1988236 Slides237 Worksheets, 1986-1989238 KIP,Vagotomy, 1981-1988239 Klawansky: Practice vs. Research, 19932310 Lag, Background, 1962-19692311 Lasker Award Documents, 19882312 Letters to Write, 1994-19952313-15 Levamisole: Papers, 1978-19922316 Levamisole: Study, 1980-19902317 Leverton, Fax Transmissions, 19952318 License2319-20 Lidocaine, 1970-19742321 Lind, James, 1953-19692322 Lipids, Diuretics and Hypertension, 1986-19882323 Liver (Diet Supplements)2324 Liver Meta-analysis, 19922325 Liver Meta-analysis Chapter, 1989-19912326-28 Liver Reference List/Result Outline/Graph, 1927-19672329 M.S. Photographs, 19932330 MACT Bib. Quality of Clinical Trials, 1966-19842331 Malpractice, 1976-19842332 Malpractice Search, 1984-19862333 Mammography2334-35 Manuel/Eric/Sylvie Urinary Tract Infection, 1971-19862336 Manuscripts, 1987-19882337 Maripa, 1974-19782338 Mas In Ris Database 2/18/93, 1990-19912339 Mason, Frank, 1983-19842340 Massachusetts Health Data Consortium, 1986-19872341 Masters in Gastroenterology, 1990-19942342 Matrix Results, 1989-19902343 Medical Data, 1980-1986241 Medical Data, 1983-1986242 Medical Decision Making Classics: A Reading List, 1988243 Medical Journalism244 Medical Journals, 1974-1978245-6 Medical Project and Workload, 1992247 Medicine and Mathematics Articles, 1968-1980248 Medline, 1983249 Medline Papers, 1980-19822410 Memorandum, 1992 Meta-analysis2411-151964-19942416 Aids Literature, 19912417 Alcohol, 19872418 As a Tool for Interpreting Clinical Trials in Liver Disease, 19902419 Caffeine, 19832420 Calcium Supplements For Ecclampsia CPEP2421 Candidates, 19882422 Candidates-Cor. Art. Changes After Bypass, 1975-19812423 Clinical Trials, 1993-19942424 Clinical Trials Unit, 1965-19852425-26 Colon Cancer, 19862427 Consulting Inc./ MetaWorks, Inc., 19952428 Descriptive2429 Epidemiologic, 19872430 Esophageal Varices, 19882431-33 In Gastroenterology, 1977-19912434 In General2435 Manuscript, 19902436 Methods II2437 of Clinical Information Service Trial, 19932438 on Obstetrics, 1970-19892439-40 Papers, 1986-19882441 Phenobaritone S.V. Hemorrhages, 19842442 Pittsburgh, Slides2443 Placebo, 19742444 Post MI Placebo Survival251 Quality Studies, 1977-1983252 Quality U.S., 1988253 Randomized Clinical Trials Paper, 1994254 Seminars, 1994255 Somatostatin, 1990-1991256 Statistical Methods257 Steps Long Forms258 Stroke Prevention, 1969-1988259 to Evaluate Analgesic Interventions2510 Topics, 19862511 Update, 19872512-13 Updates, Colon Surgery and Antibiotics, 1989 MetaWorks2514 Business Plan, 19932515 Ross on Meta-analysis, 19922516-17 Methadone: to Be Scored2518-19 Methodology, 1976-19882520 Minnesota Colon Cancer Control Study I, 19872521-23 Mirreadorf, 1990-19922524 Mosteller Renewal, 19902525 Mount Sinai School of Medicine Papers, 1974-19832526 MRI, 1988-19922527 MRI Grant, 1985-1989 Mt. Sinai2528-30 Labeled by #2531 Labeled by Trials, 1987-19912532 Medical Center Fax, 19892533 President, 19822534 Multiple Copies of Various Articles, 1976-19882535 Mutual Fund Summary, 19872536 Nafarelin Search 7/12/93, 1981-19922537 National Institute of Health: Consensus, General, 1983-19842538 National Institute of Health: Slides # to 400's2539 National Library of Medicine Application, 19802540 National Library of Medicine Original, 19902541-42 National Transportation Safety Board: Reports, 1974-19782543 National Transportation Safety Board: Tables Statistics, 19832544 Neglect of Aged, 1988-1989261 NEGM Letter, 1992 Neural Tube262-31992264 39-0207, 1985265-6 Defects, 1983-1988267 Defects Meta-analysis, 1980-1982268 New Aspirin Papers to be Scored for Joe Cappelleri, 1988-1992269 New Breast Trials, 1982-19852610 New Gastrointestinal Hemorrhage Paper, 19902611 New Hysterectomy Papers, 1980-19832612 New Peptic Papers, 1958-19652613 NIDDS Grant, National Institute of Health Meeting, 1988 Nifedipine2614 Drafts, 19952615 From Yusor, Furberg, 19942616 Overheads, 19952617 No Overall Survival, 19862618 Non-fatal Stroke2619 Nonoccupational Exposure to Polychlorinated Biphenyls, 1988-19902620 Notes2621 NSAIDS: Slides2622 Obesity Study, 19942623 Obesity/Gallstones, 1991 Observer Error26241959-19742625 Bias, 1952-19752626 Bias Radiology, 1947-19772627 Diagnosis General, 1965-19792628 Diagnosis Specific, 1974-19812629 History Talking, 1951-19792630 In Endoscopy, 1961-19722631 Laboratories, 1970-19752632 Miscellaneous, 1958-19812633 Statistics, 1959-19772634 Observer Variability2635 Observer Variability, Review, 19752636 Office of Medical Applications of Research, 1990-19912637 Old Gastrointestinal Hemorrhage Draft (VA), n.d2638-39 Old Manuscripts, 1967-19812640 Old Research Publication Bias, 1978-19892641 Opinion Research Options2642-43 Draft2644 Overheads2645-46 Poster, 19942647 Recommendations, 1989-19952648 Original Buyse, Colorectal Trials and Gastric, 1979-19842649 Original Case Fatality Rate Blank Chart for Peptic, 19902650 Orton, 1930-19422651-52 Otisis Media, 1989-1990271 Outcome Research272 Overhead273 Overheads: Matrices, 1990274 Overheads: Sample Sizes, 1992275-6 Oxford Companion to Medicine Sept. 92, 1980-1982277 Oxford Perinatal Trials278 Pack, 1988279 Pack I2710 Pack II2711 Pack Study, 1988-19892712-13 Papers, 1970-19922714 Papers: Gail's Study, 1981-19832715-16 Papers: Proofs for Journal Article, n.d2717 Park Study 1989 Data and Safety and Ethics, 19892718 Part of Peptic Manuscript, 19872719 PASF Research and Articles, 19832720 Pashos, Chris (Port Cortin), 19902721 Patients, 1973-19772722 Paula, 1994-19952723 Paula Rochon, Placebo, 19952724 Paula, Quality, 1994-19952725 Pauling, Linus, Vitamin C and Common Cold, 1971-19762726 PDQ: All 36 Trials, 19922727 PDQ: Randomized Control Trials, 1992 Peer Review2728-291978-19892730 Meeting, 1977-19882731 Presentation, 19882732 Penultimate Drafts, 19952733-34 Peptic, 1986-1991 Peptic Ulcer27351986-19912736 Peptic Ulcer (Added), 1972-19902737-40 Articles, 1947-19932741 Emergency Surgery Original Paper, 1960-19902742-43 Hemorrhage, 1970-19902744 Hemorrhage Papers, 1956-19922745-46 Papers, 1933-1991281-4 Papers, 1933-1991285 Papers, Batch 3, 1965-1985286 Peptic Ulcers, 1975-1990287 Peptic with Out Trials Abstract, 1988-1990 Peptic288-9 60-75, 1960-19672810 Fill In2811 No Trials Abstracts, 1983-19852812 Reference (very old), 1985-19882813 Pero Material: Cholesterol, 19872814 Pero Material: Randomized Control Trials, 1978-19852815-16 Persantine Thallium, 19952817 Peter Kussin, 19802818 Phenobarb in Newborns, 19872819 Phototherapy, 19982820 Physical Examination, Observer Error, 1948-19752821 Pilot Error, 1982-19832822-23 Placebo, 1983-19942824 Placebo Article, 19802825 Placebo Hypertension, 19952826 Plasma Pheresis Meta-analysis, 1981-19842827 Plasma Prednisone, New Randomized Control Trials, 1984-19852828 Plasmapheresis Paper, 1981-1984 Polychlorinated Biphenyls2829 General, 1983-19902830 Proposal, 1988-19892831 Potential Grant Applications, 19902832 Pre-eclampsia2833 Pregnancy - Corticosteroids2834 Primary Breast Cancer, 1985-19862835 Project, 19922836 Project B.P., 19882837-38 Project Gastric Freezing, 1948-19782839 Project Plasma Pheresis, 1984-19852840 Projects, 1973-1987291 Prophylactic Antibiotics292-3 Proposal, 1984-1993294 Proposal June '88, 1973-1983295 Prostate, 1986 Prostate Cancer2961989-1993297 Bony Metastases, 1993298 Hormone Therapy, 1993299 Petodata, 19932910 PSA, 1992-19932911 Radiotherapy, 19932912 Research, 1984-19862913-14 Prostate Meta-analysis, 1981-19902915 Prostateglandins for CERU Ripening, 1990-19932916 Protocol Draft, 19942917 Protocol for Meta-analysis Papers2918 PTCA vs. F. Lytic, 1993-19952919 Public Health Service Application, 1986-19892920-21 Publication Bias, 1985-19912922 Published Research, Jovell, 1985-19912923 Q.T. Syndrome Article, 1980-19892924-25 Quality of Healthcare, 1974-19812926-27 Quality of Randomized Control Trials, 19912928 Quality Scoring Forms, 19902929 Radiation Effects, 1967-19862930-31 Radiation: Normal, 1950-19662932 Radiotherapy, 1985 Randomized Control Trials2933-411953-1987301-71958-1992308 Databases, 1990309 Library Work3010 Placebo, 19803011 Rec. Future Medline, 19893012 Registry of Clinical Trials, 19933013-14 Reject: Inadequate Follow-up, 1985-19863015 Reject: No Mortality Data, 19853016 Reject: Peptic '60's, 1966-19713017 Reject: Type of Surgery, 1985311-2 Research Data [MEDLINE citations/abstracts, myocardial infarction?], 1988313 Retirement; misc. correspondence, 1970-1989314 RIP Ashes [fireplace ash fallout study], 1988315 Rochon, Pauls [placebo vs. NSAID], 1995316 Rome Talk, 1989317 Rome, Decision Analysis Articles, 1981-1987318 Route of Delivery Papers to Score for Cathy Spino/ Paolo Villari, 1992319 Rutstein, David [memorial], 1986-19873110 Sackett, David, 1976-19823111 Salt Sensitivity and Hypertension, 19883112 Sample Size Estimates, 1954-19743113 Sample Size Estimation by Cumulative Meta-analysis, n.d3114 Sampling, 1992321 Santa Fe Overheads322 Science In Medicine, 1988323 Seattle, 1983-1991324 Selection Interference and Suggestion in Clinical Trials, 1961-1978 Course in Clincal Trials and Meta-Analysis [UC Berkeley], Spring 1991325 Session I and II326 Session III327-8 Session IV, V, and VII329-10 Session VI3211 Session VIII3212-13 Session IX3214 Session X331 Session XII332-3 Session XIII334 Slide Material Evaluation of Magnetic Imaging335 Slide Material: Opinions of Experts, 1991 Slides336-101975-19903311 (old) before 1970 (No Duplicates Here), 19693312 for Keynote Address, 1990-19943313 for Talk, 19903314 MAC, 1977-19863315 Mosteller Wanted for POARP Meeting, 19863316 Unnumbered3317 Small Cell Lung Cancer, 19923318 Solar and Electric Randomized Control Trials, 19823319-20 Sorbinol: Meta-analysis, 19913321-24 Sounding Board, 1985-19873325 Statistics, 1981-19883326 Statistics Manuel and Haenszel, 19593327-29 Statistics Methods, 1962-19783330-31 Statistics Methods I, 1967-19783332-36 Statistics Methods II, 1966-19813337 Steps in Meta-analysis3338-39 Steroids, 1970-19863340 Stroke HCUA, 1987-19903341 Stroke Rate A-Transient Ischaemic Attack, 1978-19913342-43 Strokes, 19923344-45 Strokes: Wash, 19923346 Sucralfate, 1989-19923347 Sudden Death, 19893348 Sugawa Article with Referenced Papers, 1979-1990341 Summary Charts, 1991342 Surgery Meta-analysis, 1971-1981343-4 Sydney/Cocaine, 1990-1992345 TD Hyperbilirubinemia, 1983346-8 The Boston Inter-Hospital Liver Group as an Experiment in Coop. Res., 1963-1981349 The New England Journal of Medicine Article, 19583410 The Patient, 19773411 Thrombolytic Therapy, 1988-19903412 Tie Research, 19853413-14 To Be Filed, 1973-19953415 Toward Controlled Trials in Upper Gt. Bleeding Minutes, 19763416-17 Toxic Waste Dumps, National Research Council, NRC-NRS, 1980-19913418 TPA vs. Streptokinase3419 Transcriptions, 1987-1991 Transparencies342019913421 Materials Acute Treatments3422 Travel, 1975-19883423 Treatment of Burns, 1974-19763424 Trials in Gastroenterology, 19703425-26 Unblinded Aspirin Papers, 1976-1991 University Group Diabetes Program3427 Compliance and Mortality Project, 1974-19813428 FDA Survey, 19783429 History, 1971-19793430 Unsorted Slides, 19873431 Update: Breast Cancer Meta-analysis, 19853432 Updating Meta-analyses, n.d3433 Urgent, 1991-19933434 Variceal Hemorrhage, 1990 Veterans Administration3435 Clinical Epidemiology Department Lecture, 1975-19883436 Distinguishing Physicians, 19883437 Duplicates, 19863438 Grant, 19893439 Study of 20 VA Hospitals (Old Material), 1970 Vitamin C3440-411956-19773442 Adverse Effects, 1975-19773443 Adverse Effects and New Articles, 1967-19763444 and the Common Cold, 1945-19753445 and the Common Cold Controlled Trials and References Used, 1942-19673446 Deficiency of, 1972-19753447 Duplicate Articles, 1969-19733448 General Review, 1975-1977351 Other Diseases, 1971-1977352-3 Vitamins Other Than C, 1971-1979354 What's Meta-analysis, 1986-1991355 Wilson, Cedric and H.S. Loh, 1967-1974356 Wine, 1991357 Wine Final, 1990358 Wine Tasting and Meta-analysis Papers, 1990359 Workshop on Clinical Trials, Bethesda, 19933510 Wright, Dan, 1981-1982 Series 3: Hepatitis Study (Kyoto, Japan ), 1943-1970
    This series contains correspondence, reports, charts, and other data concerning Chalmers' Hepatitis Study in Japan. In 1951 he was the principal investigator of the hepatitis treatment research unit of Harvard Medical School in Kyoto, Japan. This study was later used by Chalmers to disprove the common belief that long periods of bed rest was beneficial to those suffering from acute infectious hepatitis. The series is arranged alphabetically by file folder.

    [RESTRICTED PHI POLICY] Series is restricted according to HMD's access to health information policy. Please consult the Manuscripts Curator for access to these materials.

    501 Acute Hepatitis: Jaundice Study, 1943Access Restrictions:

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    502 Choline Content and Electrolytes and Vitamins: Sample Skeleton Diets: Dietary 2nd Run, 1952-1953Access Restrictions:

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    503 Clinical Data: Onset to Time of AdmissionAccess Restrictions:

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    Correspondence504-51952-1953Access Restrictions:

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    506 from Chalmers, 1951-1952Access Restrictions:

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    361 from Kyoto, Japan: from Eckhardt, 1952Access Restrictions:

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    362 from Sasebo, Japan, 1952-1953Access Restrictions:

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    363 Kyoto, Japan, 1951-1952Access Restrictions:

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    364 Macleod, 1952-1953Access Restrictions:

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    365 to Chalmers, 1951-1952Access Restrictions:

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    366 to Kyoto, Japan, 1952Access Restrictions:

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    367 to Sasebo, Japan, 1952-1953Access Restrictions:

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    368 Watson, 1952-1953Access Restrictions:

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    Data Nara369 Final Charts and TablesAccess Restrictions:

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    3610 Master Sheets and First Labels ThereofAccess Restrictions:

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    Data Retrospective3611 Math, charts, undatedAccess Restrictions:

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    3612 Difference in Effect by TSBAccess Restrictions:

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    3615 Data V Clinical Bed Rest: Effects of AmbulationAccess Restrictions:

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    Dietary Data3617 MermeAccess Restrictions:

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    3618 Retrospective Analyses: Old Stuff: First Run X, 1952Access Restrictions:

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    3619 Discharge Dates, 1st and 2nd Run, 1952Access Restrictions:

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    371 "The Treatment of Acute Hepatitis", J. of Clinical Inverstigation, Draft I, 1955Access Restrictions:

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    372 Epidemic Hemorrhagic Fever, 1951Access Restrictions:

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    373 First Experiment, 1950Access Restrictions:

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    374 Follow-up Chart, 1952-1953Access Restrictions:

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    375 Hepatitis Survey Group, 1952Access Restrictions:

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    376 Infectious Hepatitis Lecture, 1952Access Restrictions:

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    377 Kyoto lectures, 1951-1952Access Restrictions:

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    378 Kyoto Talks, 1951Access Restrictions:

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    379 Liver biopsy blinical reports, 1952Access Restrictions:

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    3710 Nara RandomizationAccess Restrictions:

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    3711 Physical fitness testsAccess Restrictions:

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    3712-13 Preliminary Data I: Hepatitis Study: Kyoto, Japan, n.dAccess Restrictions:

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    3714 Preliminary Data II: Hepatitis Study: Kyoto, Japan, 1951Access Restrictions:

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    3715 Protocols, 1952Access Restrictions:

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    381 First Run, 1951-1952Access Restrictions:

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    382 Follow-up States, 1952-1953Access Restrictions:

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    383 Second Run, 1952Access Restrictions:

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    384 Code SheetsAccess Restrictions:

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    385 First Run DataAccess Restrictions:

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    RandomizationAccess Restrictions:

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    386 Both Runs IIIAccess Restrictions:

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    387 Data 2nd RunAccess Restrictions:

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    388 Final Data VAccess Restrictions:

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    389 First Run IAccess Restrictions:

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    3810 Retrospective Data: Preliminary LabelingAccess Restrictions:

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    3815 Veterans Follow-Up, 1951Access Restrictions:

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    3815-17 Volunteer Study, 1953Access Restrictions:

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    Clinical Trial records391 Best Rest Analysis Both Runs: Adhesive FiguresAccess Restrictions:

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    392 Case Summaries: On Patients Who Have Been Seen, 1952Access Restrictions:

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    393 [Computer Cards], 1952Access Restrictions:

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    394 Data: WeightsAccess Restrictions:

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    395 Dietary Data: Summary Master Flow Sheets: First RunAccess Restrictions:

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    Follow-up396 Form Letters, 1948-1953Access Restrictions:

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    397 NRC and Other Material, 1949-1952Access Restrictions:

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    398 Patients Addresses, 1952-1953Access Restrictions:

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    399 Study Lists, 1952Access Restrictions:

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    401-3 HepatologyAccess Restrictions:

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    404 Liver Biopsies III: PersonalAccess Restrictions:

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    411 Second Study Data Graphs [transparencies]Access Restrictions:

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    412 Master Summary Diet Sheets: Second RunAccess Restrictions:

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    413 Names, 1952Access Restrictions:

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    421-106 [Patient participation files], 1952-1953Access Restrictions:

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    431-2 [Patient information cards], 1952Access Restrictions:

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    433 [Patient notecards: Biopsi and Diagnosis Data], 1952Access Restrictions:

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    434 Protocols: Follow-up Sasebo, 1952-1953Access Restrictions:

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    435 Pts. Hospital in Interval, 1952-1953Access Restrictions:

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    436-11 Punch Cards: Patient Treatment Records, 1951-1952Access Restrictions:

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    441-4 Punch Cards: Patient Treatment Records (cont'd.), 1951-1952Access Restrictions:

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    445 Rocket Analysis Cards [patient treatment records]Access Restrictions:

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    446 Punched Card Code SheetsAccess Restrictions:

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    447 Questionnaire Responses and Tabulations, 1952-1953Access Restrictions:

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    448 Sasebo Follow-up: Original Lab Worksheets, 1952-1953Access Restrictions:

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    449 Study Controls [exam results], 1947-1948Access Restrictions:

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    [Patient observation charts], [c. 1952]451 1st Study, Ward #41Access Restrictions:

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    452 1st Study, Ward #23Access Restrictions:

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    453 1st Study, Ward #43Access Restrictions:

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    454 1st Study, Ward #21Access Restrictions:

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    461 2nd Study, Ward #23Access Restrictions:

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    462 2nd Study, Ward #41Access Restrictions:

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    463 2nd Study, Ward #43Access Restrictions:

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    464 2nd Study, Ward #21Access Restrictions:

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    465 Eosimophil CountsAccess Restrictions:

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    466 Weight Flow SheetsAccess Restrictions:

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    467 Miscellaneous First Run LaboratoryAccess Restrictions:

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    468 [Unidentified scraps/sheet portions]Access Restrictions:

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    469 [Unidentified diagnostic data, ward 21, 23, 41, 43]Access Restrictions:

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    Series 4: Publications, 1954-1995
    This series contains copies of Chalmers' published articles in such journals as the New England Journal of Medicine, The American Journal of Medicine, The Sciences, Controlled Clinical Trials, and The Mount Sinai Journal of Medicine. In addition, there are two bibliographies of Chalmers' publications. Among the many covered titles are clinical trials; meta-analysis; clinical gastroenterology and cardiology, and geriatrics.

    The series is organized into 6 sub-series covering work he authored at the Mt. Sinai Clinical Trials Unit, the Technology Assessment Group, Harvard School of Public Health, and papers submitted for publication or in press. These sub-series follow Chalmers' original order and numbering system (which is roughly chronological) as found in folder 1 of Papers, Clinical Trials Unit, Mt. Sinai, 1965-1992.

    Papers, Clinical Trials Unit, Mt. Sinai, 1965-1992471 Papers Published from Clinical Trials Unit, Mt. Sinai, 1992472 1.1 "A Note on Fatality in Serum Hepatitis", 1965473 1.2 "The Present Status of Shunts for Portal Hypertension in Cirrhosis", 1966474 1.3 "The Transaminase Tests in Liver Disease", 1967475 1.5 "Controlled Studies in Clinical Cancer Research", 1972476 1.6 "Nonevaluable Patients in Clinical Cancer Research", 1975477 1.7 "Effects of Ascorbic Acid on the Common Cold: An Evaluation of the Evidence", 1975478 1.8 "Randomized Controlled Clinical Trials in Diseases of the Liver"479 1.9 "Evidence Favoring the Use of Anticoagulants in the Hospital Phase of Acute Myocardial Infarction", 19774710 1.10 "The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial", 19784711 1.11 "In Defense of the VA Randomized Control Trial of Coronary Artery Surgery", 19784712 1.12 "When and How to Stop a Clinical Trial: Invited Remarks", 19794713 1.13 "Cost and Efficacy of the Substitution of Ambulatory for Inpatient Care", 19814714 1.15 "The Clinical Trial", 19814715 1.16 "A Survey of Clinical Trials of Antibiotic Prophylaxis in Colon Surgery: Evidence Against further Use of No-treatment Controls", 19814716 1.17 "Randomized versus Historical Controls for Clinical Trials", 19824717 1.18 "Who Will Fund Clinical Trials?", 19824718 1.19 "Informed Consent, Clinical Research, and the Practice of Medicine", 19824719 1.20 "The Inadequate Evidence for Short Hospital Stay after Hernia or Varicose Vein Stripping Surgery", 19824720 1.21 "A Potpourri of RCT Topics", 19824721 1.22 "Concluding Session: A General Discussion: Conference on Recent History of Randomized Clinical Trials", 19824722 1.23 "Sensitivity and Specificity of Clinical Trials: Randomized vs. Historical Controls", 19834723 1.24 "Physician Attitudes toward Applications of Computer Data Base Systems", 19834724 1.25 "The Challenges of Clinical Measurement", 19834725 1.26 "Impact of Randomized Control Trials on the Treatment of Alcohol Withdrawal", 19834726 1.27 "Deficiencies of Clinical Trials of Alcohol Withdrawal", 19834727 1.28 "Association of Adrenocorticosteroid Therapy and Peptic-ulcer Disease", 19834728 1.29 "Bias in Treatment Assignment in Controlled Clinical Trials", 19834729 1.30 "Peer Review Using a Paired-comparison Technique", 19844730 1.31 "Should Mild Hypertension be Treated? An Attempted Meta-analysis of the Clinical Trials", 19854731 1.32 "Should the Risk of AIDS Deter Hepatitis B Vaccination?", 19844732 1.33 "Loss of Patients in Clinical Trials that Measure Long-term Survival following Myocardial Infarction", 19864733 1.34 "An Analysis of the Costs of Ambulatory and Inpatient Care", 19864734 1.35 "Meta-analyses of Randomized Controlled Trials", 19874735 1.36 "Meta-analysis of Randomized Control Trials of Nicotine Chewing-gum", 19874736 1.37 "The Lugano Statements on Controlled Clinical Trials", 19874737 1.38 "Differing Attitudes of Industry and Academia towards Controlled Clinical Trials", 19864738 1.41 "Publication Bias and Clinical Trials", 19874739 1.42 "Antiplatelet Agents and Secondary Prevention of Stroke: A Meta-analysis of the Randomized Control Trials", 19884740 1.43 "Dipyridamole in the Treatment of Agina Pectoris: A Meta-analysis", 19874741 1.44 "Organization, Review, and Administration of Cooperative Studies (Greenberg Report): A Report from the Heart Special Project Committee to the National Advisory Heart Council, May 1967", 19884742 1.45 "A Meta-analysis of Randomized Control Trials of Progestational Agents in Pregnancy", 19894743 1.46 "Endoscopic Hemostasis: An Effective Therapy for Bleeding Peptic Ulcers", 199047 Abstracts, Clinical Trials Unit, Mt. Sinai, 1983-19874744 2.24 "Good Technology and Poor Clinical Science", 19834745 2.41 "Technical Quality Assessment of Randomized Control Trials", 198747 Books and Chapters, Clinical Trials Unit, Mt. Sinai, 1981-19854746 3.1 "Emergency Diagnosis and Treatment of Gastrointestinal Hemorrhage", 19814747 3.2 "Critique of Methods and Timing", 19814748 3.3 "The Randomized Clinical Trial as a Basis for Therapeutic Decisions", 19824749 3.4 "Early Termination of the Clinical Trial", 19824750 3.5 "Randomized Clinical Trials and the Consumer", 19824751 3.6 "The Control Bias in Clinical Trials", 19834752 3.7 "Annotated Bibliography on the Impact of RCTs on Medical Practice", 19834753 3.9 "Critical Decision making in Obtaining Laboratory Data", 19844754 3.10 "Scientific Quality and the Journal of Holistic Medicine", 19854755 3.11 "The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Controlled Trials: Survey of Two Sets of 'Negative' Trials"4756 3.12 "Meta-analysis of Randomized Control Trials: An Update of the Quality and Methodology"47 Papers, Technology Assessment Group, Harvard School of Public Health, 1979-19924757 4.1 "Problems of Omissions in Communications on Clinical Trials", 19794758 4.2 "Reporting Standards and Research Strategies for Controlled Trials: Agenda for the Editor", 19804759 4.3 "Reporting on Methods in Clinical Trials"4760 4.4 "Combination of Results of Stated Precision: I. The Optimistic Case", 19824761 4.5 "Reporting Clinical Trials in General Surgical Journals", 19844762 4.6 "Perusing the Literature", 19844763 4.7 "Using MEDLINE to Peruse the Literature", 19854764 4.8 "Perusing the Literature: Methods of Accessing MEDLINE and Related Databases", 19854765 4.9 "Using MEDLINE for Perusing the Literature: Software and Search Interface of Interest to the Medical Profession", 19854766 4.10 "Perusing the Literature: Comparison of MEDLINE Searching with a Perinatal Clinical Trials Database", 19854767 4.11 "Findings for Public Health from Meta-analysis", 19854768 4.12 "Adjuvant Chemotherapy for Breast Cancer: A Pooled Estimate Based on Published Randomized Control Trials., 19874769 4.13 "A Quality Assessment of Randomized Control Trials of Primary Treatment of Breast Cancer", 19864770 4.14 "Quality Assessment of Randomized Control Trials in Dental Research: I Methods", 19864771 4.15 "Quality Assessment of Randomized Control Trials in Dental Research: II Results: Periodontal Research", 19864772 4.16 "Look before you Quote", 19864773 4.17 "Meta-analysis in Clinical Medicine", 19874774 4.18 "Cost-effectiveness Analysis of Periodontal Disease Control", 19874775 4.19 "Adjuvant Therapy of Colorectal Cancer: Why We Still Don't Know", 19884776 4.20 "The Poor Quality of Early Evaluations of Magnetic Resonance Imaging", 19884777 4.21 "Commentary on Meta-analysis in Clinical Trials", 19884778 4.22 "More on MEDLINE Searches", 19884779 4.23 "Asbestos Exposure and Gastrointestinal Malignancy: Review and Meta-analysis", 19884780 4.24 "An Assessment of Publication Bias Using a Sample of Published Clinical Trials", 19894781 4.25 "A Meta-analysis of Alcohol Consumption in Relation to Risk of Breast Cancer", 19884782 4.26 "Meta-analysis of Randomized Control Trials as a Method of Estimating Rare Complications of Non-steroidal Anti-inflammatory Drug Therapy", 19884783 4.27 "Data Analysis in Gastroenterology: Vagotomy for Recurrent Duodenal Ulcer", 19884784 4.28 "Methodological Considerations in the Analysis of Cost-effectiveness in Dentistry", 19894785 4.29 "Chimiotherapie Adjuvante du Cancer Colorectal; qu' apprendre d'une Meta-analyse?"4786 4.32 "Publication Bias: A Problem in Interpreting Medical Data", 19884787 4.33 "Publication Bias and Dissemination of Clinical Research", 19894788 4.34 "A Comparison of Statistical Methods for Combining Event Rates from Clinical Trials", 19894789 4.35 "The Effect of Study Design on Gain in Evaluations of New Treatments in Medicine and Surgery", 19884790 4.36 "How Study Design Affects Outcomes in Comparisons of Therapy: I Medical", 19894791 4.37 "How Study Design Affects Outcomes in Comparisons of Therapy: II Surgical", 19894792 4.38 "Randomized Clinical Trials of Transdermal Nitroglycerin Systems for the Treatment of Angina: A Meta-analysis", 19884793 4.39 "The Role of Clinical Trials in Healthcare: A Personal View", 19884794 4.40 "Retrospective Analyses for Hypothesis Generation: A Commentary on the PACK Trial", 19894795 4.42 "The Quality of Primary and Secondary Research and Meta-analysis", 19894796 4.43 "Meta-analysis of Branched-chain Amino Acids in Hepatic Encephalopathy (Editorial)", 19894797 4.44 "A Review of Clinical Research in Orthodontics", 19894798 4.45 "Meta-analyses in Gastroenterology", 19894799 4.46 "Symposium: Clinical Applications of Meta-analysis", 198947100 4.47 "Meta-analytic Evidence Against Prophylactic Use of Lidocaine in Acute Myocardial Infarction", 198947101 4.49 "A Cohort Study of Summary Reports of Controlled Trials", 199047102 4.52 "Updated (Cumulative or Sequential) Meta-analyses of Histamine (H2) - Blockers in the Treatment of Bleeding Peptic Ulcers", 199047103 4.54 "Some Statistical Methods for Combining Experimental Results", 199047104 4.55 "The Need for Early Randomization in the Development of New Drugs for AIDS", 199047105 4.57 "Split-mouth and Cross-over Designs in Dental Research", 198947106 4.58 "Quality Assessment and Meta-analysis of Systemic Tetracycline Use in Chronic Adult Periodontitis", 199247107 4.59 "Problems Induced by Meta-analysis", 199147108 4.60 "A Meta-analysis of Physical Activity in the Prevention of Coronary Heart Disease", 199047109 4.61 "An Empirical Study of the Possible Relation of Treatment Differences to Quality Scores in Controlled Randomized Clinical Trials", 199047110 4.62 "Measuring Outcomes in Clinical Research", 199147111 4.63 "Using Medical Registries and Data Sets for Technology Assessment", 199147112 4.64 "Technology Assessment in the Connecticut Tumor Registry", 199147113 4.65 "Use of the SEER Cancer Registry for Technology Assessment", 199147114 4.66 "Technology Assessment in the Normative Aging Study", 199147115 4.67 "Technology Assessment in the Veterans Administration Dental Longitudinal Study", 199147116 4.68 "Technology Assessment in the Coronary Artery Surgery Study", 199147117 4.69 "Using Medical Registries and Data Sets for Technology Assessment: An Overview of Seven Case Studies", 199147118 4.71 "Meta119-analysis and Quality Assessment of Local Tetracycline use in Treatment of Chronic Adult Periodontitis", 199147119 4.72 "Update on Technology Assessment in Dentistry", 199247120 4.74 "Economic Analysis in Randomized Control Trials", 199247121 4.75 "A Comparison of Results of Meta-analyses of Randomized Control Trials and Recommendations of Clinical Experts", 199247122 4.76 "Cumulative Meta-analysis of Therapeutic Trials for Myocardial Infarction", 199247123 4.79 "Assessment of the Efficacy and Safety of Antiarrhymic Therapy for Chronic Atrial Fibrillation: Observations on the Role of Trial Design and Implications of Drug-related Mortality", 199047124 4.80 "Some Progress and Problems in Meta-analysis of Clinical Trials", 199247 Books and Chapters, Technology Assessment Group, Harvard School of Public Health, 1954-199147125 6.1 "Selected Quantitative Techniques", 195447126 6.2 "Assessing Social Innovations: An Empirical Base for Policy", 197547127 6.3 "How Well do Social Innovations Work?", 197547128 6.4 "How Frequently Do Innovations Succeed in Surgery and Anesthesia?", 197747129 6.5 "Progress in Surgery and Anesthesia: Benefits and Risks of Innovative Therapy"47130 6.6 "Combination of Results of Stated Precision: I. A More Realistic Case", 198447131 6.7 Medical Uses of Statistics47132 6.8 "A Computer-driven Shift in the Practice of Medicine", n.d47133 6.9 "Clinical Trials of Treatment", 198647134 6.10 "The Randomized Control Trials of Prevention of Myocardial Infarction", 198647135 6.11 "Meta-analysis as Applied to Post-marketing Surveillance", 198747136 6.12 "Randomized Control Trials and Meta-analysis of the Treatment of Cirrhosis of the Liver", 198747137 6.13 "Hormone Therapy for the Maintenance of Pregnancy"47138 6.14 "Clinical Trials", 198847139 6.18 "The Evaluations of Surgical Therapies", 198947140 6.22 "Who is Interested in Clinical Trials? The Potential for and Methods of Minimizing Bias in Funded Research", 199147 Papers Submitted for Publication or in Press, 1990-199547141 7.1 "Declining Incidence of Ventricular Fibrillation", 199247142 7.3 "Reporting the Results of Observational Studies: The Nutrition and Periodontal Disease Relationship"47143 7.6 "Patient Controlled Analgesia in the Postoperative Patient: Meta-analysis of Initial Randomized Control Trials", 199247144 7.8 "Antipsychotic Drugs: Is More Worse? A Meta-analysis of the Published Randomized Control Trials", 199047145 7.12 "The Design, Analysis, and Reporting of Research: Findings from Meta-analysis", 199047146 Chalmers Bibliography, 199347147 Reprints, 1992-199547 Series 5: Conferences, 1983-1991
    This series contains correspondence, notes, information packets, schedules, and travel documents relating to the various conferences Chalmers attended during the 1980s and early 1990s. The series is arranged alphabetically by file folder.

    47148 54th Scientific Meeting, American College of Rheumatology, Seattle, Washington, 10/8-11/1, 199047149 62nd Scientific Sessions, 1986-198947150 Acapulco, 6/19-22, 198947151 Agency for Health Care Policy and Research, Chicago, 6/20-21, 199147152 Agency for Health Care Policy and Research, Moshman Associates, 7/11, 199047153 AIDS, Washington, D.C., 11/19-21, 198947154 American Association for the Advancement of Science, Annual Meeting, 2/15-16, 199047155 American College of Surgeons, 10/8, 199047156 American Medical Association, Technology PD, 10/28, 198847157 Association of American Physicians, American Society of Clinical Investigations, American Federation for Clinical Trials, Washington, D.C., 4/28-5/1, 198947158 Barcelona, 199047159 China, April, 198347160-162 Collegium Ramazzini, Italy, 1986-199147163 Coolfont Conference, Environmental Epidemiology Committee, MAS, Virginia, 10/14-17, 199047164 Copy of Washington, D.C. Trip, 1/14-15, 198847165 D.C. - Chicago - D.C. - Iowa City, 11/12-18, 198847166 Dallas, 4/14-15, 198847167 Data Training Workshop Papers, BWI Airport, 199047168 Hans Popper, New Concepts in Medical Biology, December, 198847169 IMA GO 90, Bologna, Italy, 4/27-29, 198947170 Innsbruck, Rome, Corsendonck, August- September, 198847171 Institute of Medicine, May 3-June 9, 198947172 Institute of Medicine, PO Effectiveness, 198847173 International Biometric Conference, Brussels, Belgium, 7/7-11, 1987-198847174-176 International Physicians for the Prevention of Nuclear War, Inc., Montreal (includes transparencies for Katherine Forrest), 198847177 Interplan Germany, 198847178-179 Iowa City, 1988481 Iowa City, 1988482 ISI, Paris, France, 8/29-9/6, 1989483 Jassen Research Council, WASL FIB, 1988484-5 Madrid, 1990486 Minnesota Colon Cancer Study, 10/13-14, 1988487 Montreal General Hospital, PD, 9/23, 1988488 National Institutes of Health, Bethesda, MD, 10/18, 1989489 Office of Medical Applications of Research, National Institutes of Health, Meetings on Clinical Trials, 1989-904810-11 Port, Agency for Health Care Policy and Research, Baltimore, 19904812 Posch, Chicago, O'Hare, 19884813 Rochester, Minnesota Meeting, 5/21-23, 19894814 San Francisco P., 2/13-15, 19884815 Schedule and Correspondence, 1988-19894816-17 Seattle, WA, 1989-19914818 Society for Clinical Trials, Minneapolis, Minnesota, 5/15-18, 19894819 Society of Salk Scholars 3rd Annual Scientific Conference, 10/26, 19904820 Taiwan, Clinical Trials Imaging Procedures, 19834821 The Southern Society for Pediatric Research, New Orleans, 2/3-5, 1988491 Toronto, 1989492 U. Gastroenterology International, Washington, D.C., 5/14, 1989493 University of Texas Health Science Center at Dallas Medical School, Dallas, 4/14-15, 1988494 Veterans Administration, Chicago, 1983495 Washington, Katanserin, 3/14, 1988496 Washington, National Leadership, PD, 3/18, 1988497 World Congress of New Castle, New Castle, Australia, 8/29, 1990 Series 6: Audiotapes, 1963
    This series contains two reel-to-reel audiotapes. Documentation on the tapes is poor with one tape lacking any documentation. The "Pathogenesis and Medical Treatment of Ascites Thomas C. Chalmers... " tape also contains lectures by various other speakers; a table of contents is included.

    498 "Pathogenesis and Medical Treatment of Ascites" Thomas C. Chalmers, Internal Medicine, Vol. 10, Number 19, 10/7/1963499 Untitled [open reel]

    Collection Scope and Content Note

    Research files, teaching materials, correspondence, publications, conference packets and notes, audiovisuals, and personal material (1951-1995; 29 linear feet) document the life and medical career of Thomas C. Chalmers. Materials cover his career from Harvard Medical School to his final work with MetaWorks, Inc. The majority of the collection consists of subject files containing reports, articles, correspondence, and notes concerning his research interest in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. There also exists a small percentage of teaching materials in the subject files from Chalmers' various positions as lecturer and professor of medicine. The bulk of the collection spans the years 1951-1953 and 1970-1995.

    The collection is organized into 6 series: Personal and Biographical; Subject Files; Hepatitis Study, Kyoto, Japan; Publications; Conferences; and Audiotapes.

    Of significant interest in Series 4: Subject Files, is the material in the Linus Pauling and Vitamin C folders which contain information on Chalmers' debate with Pauling over the efficacy of Vitamin C as a cure for the common cold. These folders include debate transcripts, correspondence, and articles. Also of interest in this series is the MetaWorks Business Plan, 1993. This file folder includes correspondence and a 1993 summary of events relating to the company's inception. In addition, Series 5: Hepatitis Study, Kyoto, Japan is also significant for its documentation of Chalmers' 1951 to 1953 hepatitis study. Chalmers later used this study to disprove the common belief that long periods of bed rest were beneficial to those suffering from acute infectious hepatitis. This series includes correspondence, reports, charts, and other data relating to this study.

    Contents List
    Box | Folder Title
    Series 1: Personal and Biographical, 1954-1995 [series]:

    This series contains correspondence, notes, and reunion materials relating to Dr. Chalmers' family and personal life. On August 31, 1942, he married his wife Frankie Talcott with whom he had four children. This series includes correspondence with his wife and son Richard, as well as general family letters which detail some of Chalmers' trips abroad. In addition, Chalmers' Philips Exeter Academy Class of 1936 50th Reunion materials are also included in this series. The series is arranged alphabetically by file folder.

    1 1
    Boston City Hospital Retirement, 1954-1969
    1 2
    Compositions and Poems, 1983
    1 3
    Continuing Medical Education, AMA, MSSN, 1974-1985
    1 4-6
    Correspondence, 1973-1995
    1 7-9
    Correspondence, Family, 1970-1990
    1 10
    Correspondence, Family and Related Materials: China, 1983
    1 11-12
    Exeter Reunion, 1984-1986
    1 13
    Mount Sinai Contract Issues, 1975-1983
    1 14
    Position Appointments and Benefits, 1967-1972
    Series 2: Subject Files, 1927-1995 [series]:

    This series contains publications, drafts, reports, charts, and notes concerning Chalmers' research interests in the methodology of clinical trials; meta-analysis; clinical gastroenterology and cardiology; and geriatrics. A small percentage of Chalmers' teaching materials that include teaching plans and syllabi can also be found in this series. The series is arranged alphabetically by file folder.

    1 15
    2nd Batch of Blinded Prostate Papers, 1977-1992
    2 1
    2nd Batch of Blinded Prostate Papers (cont'd)
    2 2
    4 Randomized Control Trials to Show Corticosteroids, 1981-1986
    2 3
    5 AIDs Papers to Score for Paolo, 1989-1993
    2 4-7
    A. 166, 1986-1987
    2 8
    A Biological Consideration of Treatment of Breast Cancer, 1969
    2 9
    Abdominal Hysterectomy, 1972-1988
    2 10
    Abstracts: Gastro bleeding, ulcers, 1957-1992
    2 11
    Ace Inhibitors All Study, 1992-1995
    2 12
    Acute Cystitis, 1984-1985
    2 13
    Acute Cystitis/Urinary Tract Infection, 1984-1985
    2 14
    Acute Myocardial Infarction Slides
    2 15
    Acute Myocardial Infractions Helpers, 1991
    3 1
    Adjuvant Breast Cancer: Rx-Update, 1984-1986
    3 2
    Adjuvant Chemotherapy for Breast Cancer Update, 1986
    3 3
    Advanced Cancer, 1983
    3 4
    Age: Distribution of Meta-analyses [subseries]:
    3 5
    Bones and Joints, 1988-1989
    3 6
    References, Neuropsychology, 1988
     
    Agency for Health Care Policy and Research [subseries]:
    3 7
    Contract, 1990-1991
    3 8
    Renewal, 1990
    3 9
    Agenda Planning Diary, 1991
    3 10
    Agendas, 1991
    3 11
    Agendas I, 1991
     
    Aging [subseries]:
    3 12
    Section C, 1966-1988
    3 13
    Society, 1987-1988
    3 14
    Work, 1988-1990
    3 15
    AIDs
    3 16-19
    AIDs Immunology, 1976-1987
    4 1
    "Air Traffic Controller Health Change Study", 1978
    4 2
    Alpha I and Hypertension, Meta-analysis and Lipids, 1986
    4 3
    AMA Meta-analysis, 1983-1985
    4 4-5
    Amoxicillin Therapy, 1982-1985
    4 6
    Analytic Procedures, 1955
    4 7
    Angiography: Cholesterol, Good, 1978-1990
    4 8
    Ankle Fracture Fixture, 1987
    4 9
    Anti-arrhythmic Drugs
    4 10
    Antibiotic/Accepted Articles: Colon Surgery, 1981-1989
    4 11-12
    Antibiotic Hysterectomy, 1965-1992
    5 1
    Antibiotic Prophylactic, 1988-1991
    5 2
    Antibiotic Prophylactics in Surgery, 1973-1992
    5 3
    Antibiotic Rejected Articles, 1984-1989
    5 4
    Antibody E5, 1991-1992
    5 5
    Anti-inflammatory Drug Study, 1987
    5 6
    Apheresis Manuscript, 1980
    5 7
    Apheresis Randomized Control Trials, 1979-1983
    5 8
    Appendix: Report of the Secretary's Commission on Medical Malpractice
    5 9
    Appropriateness Research, 1987 [subseries]:
     
    Articles [subseries]:
    5 10-12
    1955-1978
    6 1-11
    1967-1989
    7 1-8
    1970-1995
    8 1-9
    1983-1995
    9 1
    1970-1974
    9 2
    Articles and Correspondence, 1993
    9 3
    Aircraft Accidents, 1974-1982
    9 4
    Clinical Trial, 1979
    9 5
    For Thomas C. Chalmers's Editorial, 1987-1988
    9 6
    Rejected for Gastrointestinal Hemorrhage Paper, 1937-1958
    9 7
    Rejected for Hemorrhage Paper, 1937-1958
    9 8-9
    Used for Gastrointestinal Hemorrhage Papers, 1942-1965
    9 10
    Ascorbic Acid, 1971-1977
    9 11
    Ascorbic Acid: National Institute of Health Study [slides], 1973
    9 12-13
    Aspirin Papers (Joe Cappelleri), 1974-1991
    10 1-2
    Asthma/Oral Drugs Back 85: Aspirin Dose Study, 1992
    10 3
    Atherosclerosis, 1951-1979
    10 4-5
    Autopsy Reprints Errors, 1953-1989
    10 6
    Aviation Accidents, 1980-1983
    10 7-8
    Bachrach, N., 1983-1989
    10 9
    Background, 1995
    11 1
    Batch 1: Peptic Ulcer Papers, 1979-1990
    11 2
    Batch 2: Peptic Ulcer Papers, 1981-1989
    11 3
    Berlin's, Dr.: Comments, 1995
    11 4-6
    Beta Blockers, 1993
    11 7
    Beta Data and Charts, 1978-1989
    11 8-10
    Beta Papers, 1988-1989
    11 11
    Bias Paper, 1982
    11 12
    Big vs. Small
    11 13
    Biography and Schedules
    11 14
    Bleeding Peptic Ulcer, 1986-1991
    11 15
    Bleeding Ulcers, 1989-1992
    11 16
    Blocking Agents, 1993-1994
    11 17
    Blue Book Update: Beta, 1987-1988
    11 18
    Blum File, 1987
    11 19-20
    Blum, Almanac, Dec. 7, 1987
    11 21
    Books on Errors, 1983
    11 22
    Boston City Hospital, Out-Patient Department, 1952-1954
    11 23-24
    Boston Meta-analysis Candidate, 1986-1987
    11 25
    Breast Cancer Article, 1986-1987
    11 26
    Breast Cancer Med '86, 1991
    11 27
    Breast Cancer Screening, 1987-1992
    11 28
    Breast Cancer-Reject Papers, 1986
    11 29-30
    Brian, 1990
    11 31
    Brookline Ashes, 1987
    11 32
    Burns, 1978-1987
    11 33
    Burrows Study, 1989
    11 34
    Buyse, Mark, 1984
    11 35
    Buyse, Mark: Gastric Cancer, 1977-1984
    11 36-37
    CA B6 Meta-analysis for POARP, 1989-1991
    11 38
    CABG Overheads
    11 39
    CABG Summaries
    11 40
    Cabin Air Quality, 1988
    11 41
    Cabin Air Quality Slides
    11 42
    Caesarean, 1993
    11 43
    Caesarean Charts, 1972-1989
    11 44
    Caesarean Section, 1990
    11 45
    Caesarean Section Antibiotics
    12 1-3
    Caffeine Study, 1952-1983
    12 4-6
    Calendars, 1987-1990
    12 7-8
    Cancer Articles, 1984-1986
    12 9
    Cancer Papers, 1977-1989
    13 1-2
    Cancer Papers (cont'd.)
    13 3
    Cancer Therapy, 1977-1992
    13 4
    Cardiology, 1994
    13 5
    Carlisle, Paul and Tony Singletary [burn victim slides], 1969-1981
    13 6
    Carotid Surgery, Hefan, 1985
    13 7
    CCB Overheads
    13 8-9
    Celiac Plexus Block Papers, 1972-1992
    13 10-11
    Chalmers, Iain, 1985-1988
    13 12
    Chapman and Hall, 1992-1995
    13 13
    Chapter on History of Clinical Trials, 1986-1991
    13 14
    Charts, 1986-1993
    13 15
    CHD Hormones, 1963-1979
    13 16
    CHD: ICCU, 1971-1979
    14 1
    Cholesterol and Stroke, 1992-1993
    14 2
    Cholesterol: Lowering Meta-analyses, 1974-1992
    14 3
    Chronic Effects of Tolbutamide, 1972-1974
    14 4
    Ciguatera
    14 5
    Clinical and Clim Paper Gastrointestinal Hemorrhage, n.d
    14 6
    Clinical Pharmacology in Aged, 1984
    14 7
    Clinical Pharmacology in the Elderly, 1989
     
    Clinical Trials [subseries]:
    14 8-9
    Clinical Trials, 1975-1988
    14 10
    Travel time experiment, 1977-1982
    14 11
    Grant on Technical Evolution of Literature, 1982
    14 12-13
    Clippings, 1978-1982
    14 14
    Clozapin Therapy for Schizophrenia, 1991
    14 15
    Coffee Trial, 1983
    14 16
    Cognitive Behavior Eisenberg, 1991
    15 1
    Colon Adjuvant, Recent Publication, 1985
    15 2
    Colon Cancer, 1971-1976
    15 3
    Comparison of Methods, 1992
    15 4
    Completed Forms, 1950-1976
    15 5-6
    Completed Hysterectomy Master Copies, 1973-1990
    15 7
    Computer Ethics, 1973-1976
    15 8
    Controlled Clinical Trials, 1974
    15 9
    Controlled Study Articles, 1983-1991
    15 10-12
    Controlled Therapeutic Trials, 1970-1994
    15 13
    Cook and Tryba Meta-Analysis, 1979-1991
    16 1
    Cook and Tryba Meta-Analysis (cont'd.)
     
    Correspondence [subseries]:
    16 2
    1971
    16 3-5
    1973
    16 6
    1974-1984
    16 7
    1985-1986
    16 8
    1990-1992
    16 9
    1993-1994
    16 10
    Correspondence and Meta-analysis, 1995
    16 11-12
    Correspondence and Papers, 1990-1994
    16 13
    Course: Meta-analysis, 1986
    16 14
    Course: Case Control Etc., 1984
    16 15
    Crohn's Scores: Meta-analysis, 1979-1984
    16 16
    Crohn's, 1992
    16 17
    Cumulative Meta-Analysis, 1994
    16 18
    Cumulative Meta-Analysis: Marubini Talk in Paris, 1989
    16 19
    Cumulative Rearrangements, 1976-1988
    16 20
    Current Clinical Trials, 1994
     
    CVS [subseries]:
    16 21
    Acute Myocardial Infractions, 1983
    16 22
    Angina Pectoris, 1971
    16 23
    Arteriosclerosis, 1970-1979
    17 1
    CABG, 1982-1983
    17 2
    Cineangiograph, 1979-1982
    17 3
    Coronary Reperfusion, 1982
    17 4
    Epidemiology, 1980-1983
    17 5
    Hemostosis, 1980-1981
    17 6
    Lipids Cholesterol, 1979-1980
    17 7
    Pharmacology, 1979-1980
    17 8
    Stroke, 1983
    17 9
    Type A Behavior, 1983
    17 10
    DA Grant, 1989
    17 11
    Data
    17 12
    Data and Summary of Levamisole, 1980-1990
    18 1
    Data and Summary of Levamisole (cont'd.)
    18 2
    Data(2): Hormonal Influence for Iron Absorption, 1959
    18 3
    Delays, 1985-1991
    18 4
    Delphi-1, n.d
    18 5-6
    Depression, 1988-1992
    18 7
    DHMC, 1993
    18 8-9
    Diabetes, 1984-1991
    18 10
    Diabetes Survey, 1988-1991
    18 11-13
    Diagnostic Errors, 1951-1988
    19 1
    Diet, Heart, Review, 1984
    19 2
    Digestive Diseases Grant, 1989
    19 3
    Dipyridamole, 1990
    19 4
    Dipyridamole Thallium, 1982-1986
    19 5
    Double-Blind Study, 1965
    19 6
    Drug Abuse, 1991
    19 7-8
    Drug Abuse Grant, 1989
    19 9
    Early PTCA, 1994
    19 10
    ECRI Meta-analysis, 1994
    19 11
    Edited Draft of "The Efficacy of Medical Treatments on Peripheral Diabetic Neuropathy...", 1993
    19 12
    Effective Care in Pregnancy and Childbirth: Hormones (Iain Chalmers), 1978-1986
    19 13
    Eisenberg #1 to Blind, 1990-1991
    19 14
    Eisenberg Papers, 1993
    19 15
    Eisenberg Papers for Thomas C. Chalmers, 1976-1993
    19 16
    Electronic Journal of Meta-analysis, 1984
    19 17
    Endoscopic Rx Hemorrhage
    19 18
    Epidemiologic Meta-analysis Overheads
    19 19
    Epidemiologic Survey, 1986
     
    Errors [subseries]:
    19 20
    1986-1989
    19 21
    Airplane, 1974-1982
    19 22
    Anesthesia, 1972-1983
    19 23-24
    Background Reading, 1981-1983
    19 25
    Clinicopathological Conferences, 1982
    19 26
    Current, 1983
    19 27
    Dates on Intensive Care Units, 1988
    19 28
    Manuscript, 1983
    19 29
    Manuscript II, 1983
    19 30
    March '84, 1983-1984
    19 31
    Medication, 1989
    19 32-33
    More, 1954-1983
    19 34
    Notes, 1981-1983
    19 35
    Relating Tourniquets, 1980
    19 36
    Reprints, 1981-1983
    19 37
    Ethics of Randomized Clinical Trials, 1991
    19 38
    Ethics Slides, 1972-1992
    19 39
    Etiology of Duodenitis, 1964-1977
    19 40-41
    Excluded, 1974-1983
    19 42
    Exercise, 1988
    19 43
    Expert Forms, 1991
    19 44
    Extra Applications, 1982-1986
    19 45
    Fawzi, Wafaie W., 1990-1993
    19 46
    Faxes, 1988-1989
    19 47
    Felson Study, 1991
    19 48
    Fibrinolytic Side Effects
    19 49
    Fibrinolytic Therapy Graphs, 1989
    19 50
    Final Graphs for Chlor
    19 51
    Financial Data
    19 52
    Flouty: Nifedipine, 1995
    20 1
    Folati and Malformation, 1993
    20 2-3
    Forgotten Research, 1979-1991
    20 4
    Forms and Worksheets, Meta-analysis, 1984-1985
    20 5
    Foundations, 1987-1988
    20 6
    Foundations: Iain Chalmers, 1987-1988
    20 7-8
    FTC
    20 9
    Furberg Press Releases, 1995
     
    Gail's Papers [subseries]:
    20 10
    1978-1983
    20 11
    Perfect References, 1983-1984
    20 12-13
    Project #2, 1976-1983
    20 14-21
    Study: Included, 1964-1983
    20 22-23
    Study: Jaundice, 1978-1980
    20 24
    Gamma Globulin in Post-transfusion Hep., 1977-1978
    20 25
    Gastric Freezing, 1964
    20 26
    Gastric Ulcers, 1990
    20 27-28
    Gastroenterology International, 1988-1989
    20 29
    Gastrointestinal Bleeding Articles, 1979-1989
     
    Gastrointestinal Hemorrhage [subseries]:
    20 30
    Gastrointestinal Hemorrhage, 1990
    20 31
    Collins (Studies in References), 1987-1992
    20 32
    10 and Hem. 11- Full Papers for Thomas C. Chalmers, 1983-1989
    20 33-34
    Data, 1927-1969
    20 35
    Log, 1985-1989
    21 1
    Meta-analysis Update File, 1971, 1990
    21 2
    Review and Thomas C. Chalmers, 1975-1987
    21 3
    Review Articles, 1981
    21 4
    Gastrointestinal Meta-analyses
    21 5
    Gastrointestinal New Rejects, 1990-1991
    21 6
    Gastroplasty, 1994
    21 7
    Genealogy, 1961-1962
    21 8
    Geneval, 1994
    21 9
    Geriatric Randomized Control Trials, 1988-1989
    21 10
    Good Peptics 60's, 1967-1970
    21 11
    Gray
     
    Gray, Darryl [subseries]:
    21 12-13
    1961-1987
    21 14
    Burn Excision, 1984-1986
    21 15
    E.G. Work Records Protocol, 1986
    21 16
    Front Sheets, 1976-1985
    21 17
    Greenlaw 7/5/93, 1990-1993
    21 18
    Grey Scores, 1985
    21 19
    Halothane: Ris/Case/Cohort Study Cur. Con., 1966-1986
     
    Harvard School of Public Health [subseries]:
    21 20
    1985-1986
    21 21
    11/13, 1974-1986
    21 22
    Course, Bias, Sackett, 1984
    21 23
    Course, Illness Requiring Clinical Trials, 1981-1982
    21 24
    Office, 1989
    21 25
    Health Care Crisis
    21 26
    Health Care Crisis Paper
    21 27
    Health Effects, 1991
    21 28
    Helicobater, 1993
    21 29
    Hemorrhage Reference, 1981-1989
    21 30
    Hepatitis, n.d
    21 31
    Hepatogastroenterology, 1988-1990
    21 32
    Home
    21 33
    Home Randomized Control Trials, 1981-1982
    21 34
    Home Research, 1981
    21 35-36
    Hospice Care, 1978-1984
    21 37
    Hyperbili Data, 1982-1986
     
    Hypertension [subseries]:
    21 38-39
    1988
    21 40-41
    During Pregnancy, 1969-1985
    21 42
    In Aged, 1990-1993
    21 43
    Lovell, 1981-1992
    21 44-45
    Meta-analysis, 1983-1992
    21 46-47
    Papers, 1973-1993
    21 48-50
    Study
    21 51
    Tables, 1993
    21 52
    Treatment
    21 53
    Research, 1986
    21 54-55
    Hypokaliemia and Q.T. Problems, 1982-1989
    22 1
    Iatrogenic Disease, 1955-1980
    22 2-3
    Iloprost, 1989-1990
    22 4
    Immunoterapia Advante, 1976-1986
    22 5
    Impact on Practices, 1991
    22 6
    Impact on Prostate
    22 7
    Important Squam Information: Frank Mason, 1983-1984
    22 8
    Infectious Diseases and Gastroenterology Publications, 1990-1991
    22 9
    Informed Consent, 1966-1983
    22 10
    Intermittent Claudication other Drugs, 1984-1987
    22 11
    Intracranial Hemorrhage, 1983-1986
    22 12
    Ischemia and Serotonin, 1988
    22 13
    ISI Slides, 1989
    22 14
    ISIS II, 1988
    22 15
    ISIS, 4 Overheads
    22 16
    Jacquotte, Anne Papers for Scoring, 1959-1985
    22 17
    Janssen Grant, 1988-1991
    22 18
    Janssen Pharmaceutica, 1989
    22 19-20
    Jenny Rejects, 1987-1988
    22 21
    Job Seekers [Dr. Chalmers], 1966-1973
    22 22
    Jokes
     
    Jovell, Albert J. [subseries]:
    22 23-25
    1990-1992
    22 26
    OJCC [Slides, Transparencies, Photographs]
     
    Kannry, Joe [subseries]:
    22 27-29
    1988-1989
    22 30
    Abstracts, 1988-1989
    22 31
    Papers
    22 32-37
    Project Papers, 1961-1986
     
    Ketanserin [subseries]:
    22 38
    Add, on Trials, 1987-1988
    22 39
    Comparison with other Drugs, 1986-1989
    22 40
    Hypertension
    22 41
    Intermittent Claudication, 1984-1989
    22 42
    Mechanism, 1983-1989
    23 1-2
    Mechanism, 1983-1989
    23 3
    New Reject Anti-Hypertension, 1987-1988
    23 4
    Placebo Hypertension, 1981-1987
    23 5
    Short, Meta, 1985-1988
    23 6
    Slides
    23 7
    Worksheets, 1986-1989
    23 8
    KIP,Vagotomy, 1981-1988
    23 9
    Klawansky: Practice vs. Research, 1993
    23 10
    Lag, Background, 1962-1969
    23 11
    Lasker Award Documents, 1988
    23 12
    Letters to Write, 1994-1995
    23 13-15
    Levamisole: Papers, 1978-1992
    23 16
    Levamisole: Study, 1980-1990
    23 17
    Leverton, Fax Transmissions, 1995
    23 18
    License
    23 19-20
    Lidocaine, 1970-1974
    23 21
    Lind, James, 1953-1969
    23 22
    Lipids, Diuretics and Hypertension, 1986-1988
    23 23
    Liver (Diet Supplements)
    23 24
    Liver Meta-analysis, 1992
    23 25
    Liver Meta-analysis Chapter, 1989-1991
    23 26-28
    Liver Reference List/Result Outline/Graph, 1927-1967
    23 29
    M.S. Photographs, 1993
    23 30
    MACT Bib. Quality of Clinical Trials, 1966-1984
    23 31
    Malpractice, 1976-1984
    23 32
    Malpractice Search, 1984-1986
    23 33
    Mammography
    23 34-35
    Manuel/Eric/Sylvie Urinary Tract Infection, 1971-1986
    23 36
    Manuscripts, 1987-1988
    23 37
    Maripa, 1974-1978
    23 38
    Mas In Ris Database 2/18/93, 1990-1991
    23 39
    Mason, Frank, 1983-1984
    23 40
    Massachusetts Health Data Consortium, 1986-1987
    23 41
    Masters in Gastroenterology, 1990-1994
    23 42
    Matrix Results, 1989-1990
    23 43
    Medical Data, 1980-1986
    24 1
    Medical Data, 1983-1986
    24 2
    Medical Decision Making Classics: A Reading List, 1988
    24 3
    Medical Journalism
    24 4
    Medical Journals, 1974-1978
    24 5-6
    Medical Project and Workload, 1992
    24 7
    Medicine and Mathematics Articles, 1968-1980
    24 8
    Medline, 1983
    24 9
    Medline Papers, 1980-1982
    24 10
    Memorandum, 1992
     
    Meta-analysis [subseries]:
    24 11-15
    1964-1994
    24 16
    Aids Literature, 1991
    24 17
    Alcohol, 1987
    24 18
    As a Tool for Interpreting Clinical Trials in Liver Disease, 1990
    24 19
    Caffeine, 1983
    24 20
    Calcium Supplements For Ecclampsia CPEP
    24 21
    Candidates, 1988
    24 22
    Candidates-Cor. Art. Changes After Bypass, 1975-1981
    24 23
    Clinical Trials, 1993-1994
    24 24
    Clinical Trials Unit, 1965-1985
    24 25-26
    Colon Cancer, 1986
    24 27
    Consulting Inc./ MetaWorks, Inc., 1995
    24 28
    Descriptive
    24 29
    Epidemiologic, 1987
    24 30
    Esophageal Varices, 1988
    24 31-33
    In Gastroenterology, 1977-1991
    24 34
    In General
    24 35
    Manuscript, 1990
    24 36
    Methods II
    24 37
    of Clinical Information Service Trial, 1993
    24 38
    on Obstetrics, 1970-1989
    24 39-40
    Papers, 1986-1988
    24 41
    Phenobaritone S.V. Hemorrhages, 1984
    24 42
    Pittsburgh, Slides
    24 43
    Placebo, 1974
    24 44
    Post MI Placebo Survival
    25 1
    Quality Studies, 1977-1983
    25 2
    Quality U.S., 1988
    25 3
    Randomized Clinical Trials Paper, 1994
    25 4
    Seminars, 1994
    25 5
    Somatostatin, 1990-1991
    25 6
    Statistical Methods
    25 7
    Steps Long Forms
    25 8
    Stroke Prevention, 1969-1988
    25 9
    to Evaluate Analgesic Interventions
    25 10
    Topics, 1986
    25 11
    Update, 1987
    25 12-13
    Updates, Colon Surgery and Antibiotics, 1989
     
    MetaWorks [subseries]:
    25 14
    Business Plan, 1993
    25 15
    Ross on Meta-analysis, 1992
    25 16-17
    Methadone: to Be Scored
    25 18-19
    Methodology, 1976-1988
    25 20
    Minnesota Colon Cancer Control Study I, 1987
    25 21-23
    Mirreadorf, 1990-1992
    25 24
    Mosteller Renewal, 1990
    25 25
    Mount Sinai School of Medicine Papers, 1974-1983
    25 26
    MRI, 1988-1992
    25 27
    MRI Grant, 1985-1989
     
    Mt. Sinai [subseries]:
    25 28-30
    Labeled by #
    25 31
    Labeled by Trials, 1987-1991
    25 32
    Medical Center Fax, 1989
    25 33
    President, 1982
    25 34
    Multiple Copies of Various Articles, 1976-1988
    25 35
    Mutual Fund Summary, 1987
    25 36
    Nafarelin Search 7/12/93, 1981-1992
    25 37
    National Institute of Health: Consensus, General, 1983-1984
    25 38
    National Institute of Health: Slides # to 400's
    25 39
    National Library of Medicine Application, 1980
    25 40
    National Library of Medicine Original, 1990
    25 41-42
    National Transportation Safety Board: Reports, 1974-1978
    25 43
    National Transportation Safety Board: Tables Statistics, 1983
    25 44
    Neglect of Aged, 1988-1989
    26 1
    NEGM Letter, 1992
     
    Neural Tube [subseries]:
    26 2-3
    1992
    26 4
    39-0207, 1985
    26 5-6
    Defects, 1983-1988
    26 7
    Defects Meta-analysis, 1980-1982
    26 8
    New Aspirin Papers to be Scored for Joe Cappelleri, 1988-1992
    26 9
    New Breast Trials, 1982-1985
    26 10
    New Gastrointestinal Hemorrhage Paper, 1990
    26 11
    New Hysterectomy Papers, 1980-1983
    26 12
    New Peptic Papers, 1958-1965
    26 13
    NIDDS Grant, National Institute of Health Meeting, 1988
     
    Nifedipine [subseries]:
    26 14
    Drafts, 1995
    26 15
    From Yusor, Furberg, 1994
    26 16
    Overheads, 1995
    26 17
    No Overall Survival, 1986
    26 18
    Non-fatal Stroke
    26 19
    Nonoccupational Exposure to Polychlorinated Biphenyls, 1988-1990
    26 20
    Notes
    26 21
    NSAIDS: Slides
    26 22
    Obesity Study, 1994
    26 23
    Obesity/Gallstones, 1991
     
    Observer Error [subseries]:
    26 24
    1959-1974
    26 25
    Bias, 1952-1975
    26 26
    Bias Radiology, 1947-1977
    26 27
    Diagnosis General, 1965-1979
    26 28
    Diagnosis Specific, 1974-1981
    26 29
    History Talking, 1951-1979
    26 30
    In Endoscopy, 1961-1972
    26 31
    Laboratories, 1970-1975
    26 32
    Miscellaneous, 1958-1981
    26 33
    Statistics, 1959-1977
    26 34
    Observer Variability
    26 35
    Observer Variability, Review, 1975
    26 36
    Office of Medical Applications of Research, 1990-1991
    26 37
    Old Gastrointestinal Hemorrhage Draft (VA), n.d
    26 38-39
    Old Manuscripts, 1967-1981
    26 40
    Old Research Publication Bias, 1978-1989
    26 41
    Opinion Research
     
    Options [subseries]:
    26 42-43
    Draft
    26 44
    Overheads
    26 45-46
    Poster, 1994
    26 47
    Recommendations, 1989-1995
    26 48
    Original Buyse, Colorectal Trials and Gastric, 1979-1984
    26 49
    Original Case Fatality Rate Blank Chart for Peptic, 1990
    26 50
    Orton, 1930-1942
    26 51-52
    Otisis Media, 1989-1990
    27 1
    Outcome Research
    27 2
    Overhead
    27 3
    Overheads: Matrices, 1990
    27 4
    Overheads: Sample Sizes, 1992
    27 5-6
    Oxford Companion to Medicine Sept. 92, 1980-1982
    27 7
    Oxford Perinatal Trials
    27 8
    Pack, 1988
    27 9
    Pack I
    27 10
    Pack II
    27 11
    Pack Study, 1988-1989
    27 12-13
    Papers, 1970-1992
    27 14
    Papers: Gail's Study, 1981-1983
    27 15-16
    Papers: Proofs for Journal Article, n.d
    27 17
    Park Study 1989 Data and Safety and Ethics, 1989
    27 18
    Part of Peptic Manuscript, 1987
    27 19
    PASF Research and Articles, 1983
    27 20
    Pashos, Chris (Port Cortin), 1990
    27 21
    Patients, 1973-1977
    27 22
    Paula, 1994-1995
    27 23
    Paula Rochon, Placebo, 1995
    27 24
    Paula, Quality, 1994-1995
    27 25
    Pauling, Linus, Vitamin C and Common Cold, 1971-1976
    27 26
    PDQ: All 36 Trials, 1992
    27 27
    PDQ: Randomized Control Trials, 1992
     
    Peer Review [subseries]:
    27 28-29
    1978-1989
    27 30
    Meeting, 1977-1988
    27 31
    Presentation, 1988
    27 32
    Penultimate Drafts, 1995
    27 33-34
    Peptic, 1986-1991
     
    Peptic Ulcer [subseries]:
    27 35
    1986-1991
    27 36
    Peptic Ulcer (Added), 1972-1990
    27 37-40
    Articles, 1947-1993
    27 41
    Emergency Surgery Original Paper, 1960-1990
    27 42-43
    Hemorrhage, 1970-1990
    27 44
    Hemorrhage Papers, 1956-1992
    27 45-46
    Papers, 1933-1991
    28 1-4
    Papers, 1933-1991
    28 5
    Papers, Batch 3, 1965-1985
    28 6
    Peptic Ulcers, 1975-1990
    28 7
    Peptic with Out Trials Abstract, 1988-1990
     
    Peptic [subseries]:
    28 8-9
    60-75, 1960-1967
    28 10
    Fill In
    28 11
    No Trials Abstracts, 1983-1985
    28 12
    Reference (very old), 1985-1988
    28 13
    Pero Material: Cholesterol, 1987
    28 14
    Pero Material: Randomized Control Trials, 1978-1985
    28 15-16
    Persantine Thallium, 1995
    28 17
    Peter Kussin, 1980
    28 18
    Phenobarb in Newborns, 1987
    28 19
    Phototherapy, 1998
    28 20
    Physical Examination, Observer Error, 1948-1975
    28 21
    Pilot Error, 1982-1983
    28 22-23
    Placebo, 1983-1994
    28 24
    Placebo Article, 1980
    28 25
    Placebo Hypertension, 1995
    28 26
    Plasma Pheresis Meta-analysis, 1981-1984
    28 27
    Plasma Prednisone, New Randomized Control Trials, 1984-1985
    28 28
    Plasmapheresis Paper, 1981-1984
     
    Polychlorinated Biphenyls [subseries]:
    28 29
    General, 1983-1990
    28 30
    Proposal, 1988-1989
    28 31
    Potential Grant Applications, 1990
    28 32
    Pre-eclampsia
    28 33
    Pregnancy - Corticosteroids
    28 34
    Primary Breast Cancer, 1985-1986
    28 35
    Project, 1992
    28 36
    Project B.P., 1988
    28 37-38
    Project Gastric Freezing, 1948-1978
    28 39
    Project Plasma Pheresis, 1984-1985
    28 40
    Projects, 1973-1987
    29 1
    Prophylactic Antibiotics
    29 2-3
    Proposal, 1984-1993
    29 4
    Proposal June '88, 1973-1983
    29 5
    Prostate, 1986
     
    Prostate Cancer [subseries]:
    29 6
    1989-1993
    29 7
    Bony Metastases, 1993
    29 8
    Hormone Therapy, 1993
    29 9
    Petodata, 1993
    29 10
    PSA, 1992-1993
    29 11
    Radiotherapy, 1993
    29 12
    Research, 1984-1986
    29 13-14
    Prostate Meta-analysis, 1981-1990
    29 15
    Prostateglandins for CERU Ripening, 1990-1993
    29 16
    Protocol Draft, 1994
    29 17
    Protocol for Meta-analysis Papers
    29 18
    PTCA vs. F. Lytic, 1993-1995
    29 19
    Public Health Service Application, 1986-1989
    29 20-21
    Publication Bias, 1985-1991
    29 22
    Published Research, Jovell, 1985-1991
    29 23
    Q.T. Syndrome Article, 1980-1989
    29 24-25
    Quality of Healthcare, 1974-1981
    29 26-27
    Quality of Randomized Control Trials, 1991
    29 28
    Quality Scoring Forms, 1990
    29 29
    Radiation Effects, 1967-1986
    29 30-31
    Radiation: Normal, 1950-1966
    29 32
    Radiotherapy, 1985
     
    Randomized Control Trials [subseries]:
    29 33-41
    1953-1987
    30 1-7
    1958-1992
    30 8
    Databases, 1990
    30 9
    Library Work
    30 10
    Placebo, 1980
    30 11
    Rec. Future Medline, 1989
    30 12
    Registry of Clinical Trials, 1993
    30 13-14
    Reject: Inadequate Follow-up, 1985-1986
    30 15
    Reject: No Mortality Data, 1985
    30 16
    Reject: Peptic '60's, 1966-1971
    30 17
    Reject: Type of Surgery, 1985
    31 1-2
    Research Data [MEDLINE citations/abstracts, myocardial infarction?], 1988
    31 3
    Retirement; misc. correspondence, 1970-1989
    31 4
    RIP Ashes [fireplace ash fallout study], 1988
    31 5
    Rochon, Pauls [placebo vs. NSAID], 1995
    31 6
    Rome Talk, 1989
    31 7
    Rome, Decision Analysis Articles, 1981-1987
    31 8
    Route of Delivery Papers to Score for Cathy Spino/ Paolo Villari, 1992
    31 9
    Rutstein, David [memorial], 1986-1987
    31 10
    Sackett, David, 1976-1982
    31 11
    Salt Sensitivity and Hypertension, 1988
    31 12
    Sample Size Estimates, 1954-1974
    31 13
    Sample Size Estimation by Cumulative Meta-analysis, n.d
    31 14
    Sampling, 1992
    32 1
    Santa Fe Overheads
    32 2
    Science In Medicine, 1988
    32 3
    Seattle, 1983-1991
    32 4
    Selection Interference and Suggestion in Clinical Trials, 1961-1978
    Course in Clincal Trials and Meta-Analysis [UC Berkeley], Spring 1991 [subseries]:
    32 5
    Session I and II
    32 6
    Session III
    32 7-8
    Session IV, V, and VII
    32 9-10
    Session VI
    32 11
    Session VIII
    32 12-13
    Session IX
    32 14
    Session X
    33 1
    Session XII
    33 2-3
    Session XIII
    33 4
    Slide Material Evaluation of Magnetic Imaging
    33 5
    Slide Material: Opinions of Experts, 1991
     
    Slides [subseries]:
    33 6-10
    1975-1990
    33 11
    (old) before 1970 (No Duplicates Here), 1969
    33 12
    for Keynote Address, 1990-1994
    33 13
    for Talk, 1990
    33 14
    MAC, 1977-1986
    33 15
    Mosteller Wanted for POARP Meeting, 1986
    33 16
    Unnumbered
    33 17
    Small Cell Lung Cancer, 1992
    33 18
    Solar and Electric Randomized Control Trials, 1982
    33 19-20
    Sorbinol: Meta-analysis, 1991
    33 21-24
    Sounding Board, 1985-1987
    33 25
    Statistics, 1981-1988
    33 26
    Statistics Manuel and Haenszel, 1959
    33 27-29
    Statistics Methods, 1962-1978
    33 30-31
    Statistics Methods I, 1967-1978
    33 32-36
    Statistics Methods II, 1966-1981
    33 37
    Steps in Meta-analysis
    33 38-39
    Steroids, 1970-1986
    33 40
    Stroke HCUA, 1987-1990
    33 41
    Stroke Rate A-Transient Ischaemic Attack, 1978-1991
    33 42-43
    Strokes, 1992
    33 44-45
    Strokes: Wash, 1992
    33 46
    Sucralfate, 1989-1992
    33 47
    Sudden Death, 1989
    33 48
    Sugawa Article with Referenced Papers, 1979-1990
    34 1
    Summary Charts, 1991
    34 2
    Surgery Meta-analysis, 1971-1981
    34 3-4
    Sydney/Cocaine, 1990-1992
    34 5
    TD Hyperbilirubinemia, 1983
    34 6-8
    The Boston Inter-Hospital Liver Group as an Experiment in Coop. Res., 1963-1981
    34 9
    The New England Journal of Medicine Article, 1958
    34 10
    The Patient, 1977
    34 11
    Thrombolytic Therapy, 1988-1990
    34 12
    Tie Research, 1985
    34 13-14
    To Be Filed, 1973-1995
    34 15
    Toward Controlled Trials in Upper Gt. Bleeding Minutes, 1976
    34 16-17
    Toxic Waste Dumps, National Research Council, NRC-NRS, 1980-1991
    34 18
    TPA vs. Streptokinase
    34 19
    Transcriptions, 1987-1991
     
    Transparencies [subseries]:
    34 20
    1991
    34 21
    Materials Acute Treatments
    34 22
    Travel, 1975-1988
    34 23
    Treatment of Burns, 1974-1976
    34 24
    Trials in Gastroenterology, 1970
    34 25-26
    Unblinded Aspirin Papers, 1976-1991
     
    University Group Diabetes Program [subseries]:
    34 27
    Compliance and Mortality Project, 1974-1981
    34 28
    FDA Survey, 1978
    34 29
    History, 1971-1979
    34 30
    Unsorted Slides, 1987
    34 31
    Update: Breast Cancer Meta-analysis, 1985
    34 32
    Updating Meta-analyses, n.d
    34 33
    Urgent, 1991-1993
    34 34
    Variceal Hemorrhage, 1990
     
    Veterans Administration [subseries]:
    34 35
    Clinical Epidemiology Department Lecture, 1975-1988
    34 36
    Distinguishing Physicians, 1988
    34 37
    Duplicates, 1986
    34 38
    Grant, 1989
    34 39
    Study of 20 VA Hospitals (Old Material), 1970
     
    Vitamin C [subseries]:
    34 40-41
    1956-1977
    34 42
    Adverse Effects, 1975-1977
    34 43
    Adverse Effects and New Articles, 1967-1976
    34 44
    and the Common Cold, 1945-1975
    34 45
    and the Common Cold Controlled Trials and References Used, 1942-1967
    34 46
    Deficiency of, 1972-1975
    34 47
    Duplicate Articles, 1969-1973
    34 48
    General Review, 1975-1977
    35 1
    Other Diseases, 1971-1977
    35 2-3
    Vitamins Other Than C, 1971-1979
    35 4
    What's Meta-analysis, 1986-1991
    35 5
    Wilson, Cedric and H.S. Loh, 1967-1974
    35 6
    Wine, 1991
    35 7
    Wine Final, 1990
    35 8
    Wine Tasting and Meta-analysis Papers, 1990
    35 9
    Workshop on Clinical Trials, Bethesda, 1993
    35 10
    Wright, Dan, 1981-1982
     
    Series 3: Hepatitis Study (Kyoto, Japan ), 1943-1970 [series]:

    This series contains correspondence, reports, charts, and other data concerning Chalmers' Hepatitis Study in Japan. In 1951 he was the principal investigator of the hepatitis treatment research unit of Harvard Medical School in Kyoto, Japan. This study was later used by Chalmers to disprove the common belief that long periods of bed rest was beneficial to those suffering from acute infectious hepatitis. The series is arranged alphabetically by file folder.

    [RESTRICTED PHI POLICY] Series is restricted according to HMD's access to health information policy. Please consult the Manuscripts Curator for access to these materials.

    50 1
    Acute Hepatitis: Jaundice Study, 1943 [RESTRICTED PHI POLICY]
    50 2
    Choline Content and Electrolytes and Vitamins: Sample Skeleton Diets: Dietary 2nd Run, 1952-1953 [RESTRICTED PHI POLICY]
    50 3
    Clinical Data: Onset to Time of Admission [RESTRICTED PHI POLICY]
     
    Correspondence [subseries]:
    50 4-5
    1952-1953 [RESTRICTED PHI POLICY]
    50 6
    from Chalmers, 1951-1952 [RESTRICTED PHI POLICY]
    36 1
    from Kyoto, Japan: from Eckhardt, 1952 [RESTRICTED PHI POLICY]
    36 2
    from Sasebo, Japan, 1952-1953 [RESTRICTED PHI POLICY]
    36 3
    Kyoto, Japan, 1951-1952 [RESTRICTED PHI POLICY]
    36 4
    Macleod, 1952-1953 [RESTRICTED PHI POLICY]
    36 5
    to Chalmers, 1951-1952 [RESTRICTED PHI POLICY]
    36 6
    to Kyoto, Japan, 1952 [RESTRICTED PHI POLICY]
    36 7
    to Sasebo, Japan, 1952-1953 [RESTRICTED PHI POLICY]
    36 8
    Watson, 1952-1953 [RESTRICTED PHI POLICY]
     
    Data Nara [subseries]:
    36 9
    Final Charts and Tables [RESTRICTED PHI POLICY]
    36 10
    Master Sheets and First Labels Thereof [RESTRICTED PHI POLICY]
     
    Data Retrospective [subseries]:
    36 11
    Math, charts, undated [RESTRICTED PHI POLICY]
    36 12
    Difference in Effect by TSB [RESTRICTED PHI POLICY]
    36 13
    Effects of Punch Card Items in Course [RESTRICTED PHI POLICY]
    36 14
    Rising TSB [RESTRICTED PHI POLICY]
    36 15
    Data V Clinical Bed Rest: Effects of Ambulation [RESTRICTED PHI POLICY]
    36 16
    Data VIII Major: 4 Relapses, Etc. [RESTRICTED PHI POLICY]
     
    Dietary Data [subseries]:
    36 17
    Merme [RESTRICTED PHI POLICY]
    36 18
    Retrospective Analyses: Old Stuff: First Run X, 1952 [RESTRICTED PHI POLICY]
    36 19
    Discharge Dates, 1st and 2nd Run, 1952 [RESTRICTED PHI POLICY]
    37 1
    "The Treatment of Acute Hepatitis", J. of Clinical Inverstigation, Draft I, 1955 [RESTRICTED PHI POLICY]
    37 2
    Epidemic Hemorrhagic Fever, 1951 [RESTRICTED PHI POLICY]
    37 3
    First Experiment, 1950 [RESTRICTED PHI POLICY]
    37 4
    Follow-up Chart, 1952-1953 [RESTRICTED PHI POLICY]
    37 5
    Hepatitis Survey Group, 1952 [RESTRICTED PHI POLICY]
    37 6
    Infectious Hepatitis Lecture, 1952 [RESTRICTED PHI POLICY]
    37 7
    Kyoto lectures, 1951-1952 [RESTRICTED PHI POLICY]
    37 8
    Kyoto Talks, 1951 [RESTRICTED PHI POLICY]
    37 9
    Liver biopsy blinical reports, 1952 [RESTRICTED PHI POLICY]
    37 10
    Nara Randomization [RESTRICTED PHI POLICY]
    37 11
    Physical fitness tests [RESTRICTED PHI POLICY]
    37 12-13
    Preliminary Data I: Hepatitis Study: Kyoto, Japan, n.d [RESTRICTED PHI POLICY]
    37 14
    Preliminary Data II: Hepatitis Study: Kyoto, Japan, 1951 [RESTRICTED PHI POLICY]
    37 15
    Protocols, 1952 [subseries]:  [RESTRICTED PHI POLICY]
    38 1
    First Run, 1951-1952 [RESTRICTED PHI POLICY]
    38 2
    Follow-up States, 1952-1953 [RESTRICTED PHI POLICY]
    38 3
    Second Run, 1952 [RESTRICTED PHI POLICY]
    38 4
    Code Sheets [RESTRICTED PHI POLICY]
    38 5
    First Run Data [RESTRICTED PHI POLICY]
     
    Randomization [subseries]:  [RESTRICTED PHI POLICY]
    38 6
    Both Runs III [RESTRICTED PHI POLICY]
    38 7
    Data 2nd Run [RESTRICTED PHI POLICY]
    38 8
    Final Data V [RESTRICTED PHI POLICY]
    38 9
    First Run I [RESTRICTED PHI POLICY]
    38 10
    Retrospective Data: Preliminary Labeling [RESTRICTED PHI POLICY]
    38 11
    Study One and Two [RESTRICTED PHI POLICY]
    38 12
    Supreme Sheet 1st and 2nd Run Data [RESTRICTED PHI POLICY]
    38 13-14
    The Second Experiment [RESTRICTED PHI POLICY]
    38 15
    Veterans Follow-Up, 1951 [RESTRICTED PHI POLICY]
    38 15-17
    Volunteer Study, 1953 [RESTRICTED PHI POLICY]
     
    Clinical Trial records [subseries]:
    39 1
    Best Rest Analysis Both Runs: Adhesive Figures [RESTRICTED PHI POLICY]
    39 2
    Case Summaries: On Patients Who Have Been Seen, 1952 [RESTRICTED PHI POLICY]
    39 3
    [Computer Cards], 1952 [RESTRICTED PHI POLICY]
    39 4
    Data: Weights [RESTRICTED PHI POLICY]
    39 5
    Dietary Data: Summary Master Flow Sheets: First Run [RESTRICTED PHI POLICY]
     
    Follow-up [subseries]:
    39 6
    Form Letters, 1948-1953 [RESTRICTED PHI POLICY]
    39 7
    NRC and Other Material, 1949-1952 [RESTRICTED PHI POLICY]
    39 8
    Patients Addresses, 1952-1953 [RESTRICTED PHI POLICY]
    39 9
    Study Lists, 1952 [RESTRICTED PHI POLICY]
    40 1-3
    Hepatology [RESTRICTED PHI POLICY]
    40 4
    Liver Biopsies III: Personal [RESTRICTED PHI POLICY]
    41 1
    Second Study Data Graphs [transparencies] [RESTRICTED PHI POLICY]
    41 2
    Master Summary Diet Sheets: Second Run [RESTRICTED PHI POLICY]
    41 3
    Names, 1952 [RESTRICTED PHI POLICY]
    42 1-106
    [Patient participation files], 1952-1953 [RESTRICTED PHI POLICY]
    43 1-2
    [Patient information cards], 1952 [RESTRICTED PHI POLICY]
    43 3
    [Patient notecards: Biopsi and Diagnosis Data], 1952 [RESTRICTED PHI POLICY]
    43 4
    Protocols: Follow-up Sasebo, 1952-1953 [RESTRICTED PHI POLICY]
    43 5
    Pts. Hospital in Interval, 1952-1953 [RESTRICTED PHI POLICY]
    43 6-11
    Punch Cards: Patient Treatment Records, 1951-1952 [RESTRICTED PHI POLICY]
    44 1-4
    Punch Cards: Patient Treatment Records (cont'd.), 1951-1952 [RESTRICTED PHI POLICY]
    44 5
    Rocket Analysis Cards [patient treatment records] [RESTRICTED PHI POLICY]
    44 6
    Punched Card Code Sheets [RESTRICTED PHI POLICY]
    44 7
    Questionnaire Responses and Tabulations, 1952-1953 [RESTRICTED PHI POLICY]
    44 8
    Sasebo Follow-up: Original Lab Worksheets, 1952-1953 [RESTRICTED PHI POLICY]
    44 9
    Study Controls [exam results], 1947-1948 [RESTRICTED PHI POLICY]
     
    [Patient observation charts], [c. 1952] [subseries]:
    45 1
    1st Study, Ward #41 [RESTRICTED PHI POLICY]
    45 2
    1st Study, Ward #23 [RESTRICTED PHI POLICY]
    45 3
    1st Study, Ward #43 [RESTRICTED PHI POLICY]
    45 4
    1st Study, Ward #21 [RESTRICTED PHI POLICY]
    46 1
    2nd Study, Ward #23 [RESTRICTED PHI POLICY]
    46 2
    2nd Study, Ward #41 [RESTRICTED PHI POLICY]
    46 3
    2nd Study, Ward #43 [RESTRICTED PHI POLICY]
    46 4
    2nd Study, Ward #21 [RESTRICTED PHI POLICY]
    46 5
    Eosimophil Counts [RESTRICTED PHI POLICY]
    46 6
    Weight Flow Sheets [RESTRICTED PHI POLICY]
    46 7
    Miscellaneous First Run Laboratory [RESTRICTED PHI POLICY]
    46 8
    [Unidentified scraps/sheet portions] [RESTRICTED PHI POLICY]
    46 9
    [Unidentified diagnostic data, ward 21, 23, 41, 43] [RESTRICTED PHI POLICY]
    Series 4: Publications, 1954-1995 [series]:

    This series contains copies of Chalmers' published articles in such journals as the New England Journal of Medicine, The American Journal of Medicine, The Sciences, Controlled Clinical Trials, and The Mount Sinai Journal of Medicine. In addition, there are two bibliographies of Chalmers' publications. Among the many covered titles are clinical trials; meta-analysis; clinical gastroenterology and cardiology, and geriatrics.

    The series is organized into 6 sub-series covering work he authored at the Mt. Sinai Clinical Trials Unit, the Technology Assessment Group, Harvard School of Public Health, and papers submitted for publication or in press. These sub-series follow Chalmers' original order and numbering system (which is roughly chronological) as found in folder 1 of Papers, Clinical Trials Unit, Mt. Sinai, 1965-1992.

     
    Papers, Clinical Trials Unit, Mt. Sinai, 1965-1992 [subseries]:
    47 1
    Papers Published from Clinical Trials Unit, Mt. Sinai, 1992
    47 2
    1.1 "A Note on Fatality in Serum Hepatitis", 1965
    47 3
    1.2 "The Present Status of Shunts for Portal Hypertension in Cirrhosis", 1966
    47 4
    1.3 "The Transaminase Tests in Liver Disease", 1967
    47 5
    1.5 "Controlled Studies in Clinical Cancer Research", 1972
    47 6
    1.6 "Nonevaluable Patients in Clinical Cancer Research", 1975
    47 7
    1.7 "Effects of Ascorbic Acid on the Common Cold: An Evaluation of the Evidence", 1975
    47 8
    1.8 "Randomized Controlled Clinical Trials in Diseases of the Liver"
    47 9
    1.9 "Evidence Favoring the Use of Anticoagulants in the Hospital Phase of Acute Myocardial Infarction", 1977
    47 10
    1.10 "The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial", 1978
    47 11
    1.11 "In Defense of the VA Randomized Control Trial of Coronary Artery Surgery", 1978
    47 12
    1.12 "When and How to Stop a Clinical Trial: Invited Remarks", 1979
    47 13
    1.13 "Cost and Efficacy of the Substitution of Ambulatory for Inpatient Care", 1981
    47 14
    1.15 "The Clinical Trial", 1981
    47 15
    1.16 "A Survey of Clinical Trials of Antibiotic Prophylaxis in Colon Surgery: Evidence Against further Use of No-treatment Controls", 1981
    47 16
    1.17 "Randomized versus Historical Controls for Clinical Trials", 1982
    47 17
    1.18 "Who Will Fund Clinical Trials?", 1982
    47 18
    1.19 "Informed Consent, Clinical Research, and the Practice of Medicine", 1982
    47 19
    1.20 "The Inadequate Evidence for Short Hospital Stay after Hernia or Varicose Vein Stripping Surgery", 1982
    47 20
    1.21 "A Potpourri of RCT Topics", 1982
    47 21
    1.22 "Concluding Session: A General Discussion: Conference on Recent History of Randomized Clinical Trials", 1982
    47 22
    1.23 "Sensitivity and Specificity of Clinical Trials: Randomized vs. Historical Controls", 1983
    47 23
    1.24 "Physician Attitudes toward Applications of Computer Data Base Systems", 1983
    47 24
    1.25 "The Challenges of Clinical Measurement", 1983
    47 25
    1.26 "Impact of Randomized Control Trials on the Treatment of Alcohol Withdrawal", 1983
    47 26
    1.27 "Deficiencies of Clinical Trials of Alcohol Withdrawal", 1983
    47 27
    1.28 "Association of Adrenocorticosteroid Therapy and Peptic-ulcer Disease", 1983
    47 28
    1.29 "Bias in Treatment Assignment in Controlled Clinical Trials", 1983
    47 29
    1.30 "Peer Review Using a Paired-comparison Technique", 1984
    47 30
    1.31 "Should Mild Hypertension be Treated? An Attempted Meta-analysis of the Clinical Trials", 1985
    47 31
    1.32 "Should the Risk of AIDS Deter Hepatitis B Vaccination?", 1984
    47 32
    1.33 "Loss of Patients in Clinical Trials that Measure Long-term Survival following Myocardial Infarction", 1986
    47 33
    1.34 "An Analysis of the Costs of Ambulatory and Inpatient Care", 1986
    47 34
    1.35 "Meta-analyses of Randomized Controlled Trials", 1987
    47 35
    1.36 "Meta-analysis of Randomized Control Trials of Nicotine Chewing-gum", 1987
    47 36
    1.37 "The Lugano Statements on Controlled Clinical Trials", 1987
    47 37
    1.38 "Differing Attitudes of Industry and Academia towards Controlled Clinical Trials", 1986
    47 38
    1.41 "Publication Bias and Clinical Trials", 1987
    47 39
    1.42 "Antiplatelet Agents and Secondary Prevention of Stroke: A Meta-analysis of the Randomized Control Trials", 1988
    47 40
    1.43 "Dipyridamole in the Treatment of Agina Pectoris: A Meta-analysis", 1987
    47 41
    1.44 "Organization, Review, and Administration of Cooperative Studies (Greenberg Report): A Report from the Heart Special Project Committee to the National Advisory Heart Council, May 1967", 1988
    47 42
    1.45 "A Meta-analysis of Randomized Control Trials of Progestational Agents in Pregnancy", 1989
    47 43
    1.46 "Endoscopic Hemostasis: An Effective Therapy for Bleeding Peptic Ulcers", 1990
    47
    Abstracts, Clinical Trials Unit, Mt. Sinai, 1983-1987 [subseries]:
    47 44
    2.24 "Good Technology and Poor Clinical Science", 1983
    47 45
    2.41 "Technical Quality Assessment of Randomized Control Trials", 1987
    47
    Books and Chapters, Clinical Trials Unit, Mt. Sinai, 1981-1985 [subseries]:
    47 46
    3.1 "Emergency Diagnosis and Treatment of Gastrointestinal Hemorrhage", 1981
    47 47
    3.2 "Critique of Methods and Timing", 1981
    47 48
    3.3 "The Randomized Clinical Trial as a Basis for Therapeutic Decisions", 1982
    47 49
    3.4 "Early Termination of the Clinical Trial", 1982
    47 50
    3.5 "Randomized Clinical Trials and the Consumer", 1982
    47 51
    3.6 "The Control Bias in Clinical Trials", 1983
    47 52
    3.7 "Annotated Bibliography on the Impact of RCTs on Medical Practice", 1983
    47 53
    3.9 "Critical Decision making in Obtaining Laboratory Data", 1984
    47 54
    3.10 "Scientific Quality and the Journal of Holistic Medicine", 1985
    47 55
    3.11 "The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Controlled Trials: Survey of Two Sets of 'Negative' Trials"
    47 56
    3.12 "Meta-analysis of Randomized Control Trials: An Update of the Quality and Methodology"
    47
    Papers, Technology Assessment Group, Harvard School of Public Health, 1979-1992 [subseries]:
    47 57
    4.1 "Problems of Omissions in Communications on Clinical Trials", 1979
    47 58
    4.2 "Reporting Standards and Research Strategies for Controlled Trials: Agenda for the Editor", 1980
    47 59
    4.3 "Reporting on Methods in Clinical Trials"
    47 60
    4.4 "Combination of Results of Stated Precision: I. The Optimistic Case", 1982
    47 61
    4.5 "Reporting Clinical Trials in General Surgical Journals", 1984
    47 62
    4.6 "Perusing the Literature", 1984
    47 63
    4.7 "Using MEDLINE to Peruse the Literature", 1985
    47 64
    4.8 "Perusing the Literature: Methods of Accessing MEDLINE and Related Databases", 1985
    47 65
    4.9 "Using MEDLINE for Perusing the Literature: Software and Search Interface of Interest to the Medical Profession", 1985
    47 66
    4.10 "Perusing the Literature: Comparison of MEDLINE Searching with a Perinatal Clinical Trials Database", 1985
    47 67
    4.11 "Findings for Public Health from Meta-analysis", 1985
    47 68
    4.12 "Adjuvant Chemotherapy for Breast Cancer: A Pooled Estimate Based on Published Randomized Control Trials., 1987
    47 69
    4.13 "A Quality Assessment of Randomized Control Trials of Primary Treatment of Breast Cancer", 1986
    47 70
    4.14 "Quality Assessment of Randomized Control Trials in Dental Research: I Methods", 1986
    47 71
    4.15 "Quality Assessment of Randomized Control Trials in Dental Research: II Results: Periodontal Research", 1986
    47 72
    4.16 "Look before you Quote", 1986
    47 73
    4.17 "Meta-analysis in Clinical Medicine", 1987
    47 74
    4.18 "Cost-effectiveness Analysis of Periodontal Disease Control", 1987
    47 75
    4.19 "Adjuvant Therapy of Colorectal Cancer: Why We Still Don't Know", 1988
    47 76
    4.20 "The Poor Quality of Early Evaluations of Magnetic Resonance Imaging", 1988
    47 77
    4.21 "Commentary on Meta-analysis in Clinical Trials", 1988
    47 78
    4.22 "More on MEDLINE Searches", 1988
    47 79
    4.23 "Asbestos Exposure and Gastrointestinal Malignancy: Review and Meta-analysis", 1988
    47 80
    4.24 "An Assessment of Publication Bias Using a Sample of Published Clinical Trials", 1989
    47 81
    4.25 "A Meta-analysis of Alcohol Consumption in Relation to Risk of Breast Cancer", 1988
    47 82
    4.26 "Meta-analysis of Randomized Control Trials as a Method of Estimating Rare Complications of Non-steroidal Anti-inflammatory Drug Therapy", 1988
    47 83
    4.27 "Data Analysis in Gastroenterology: Vagotomy for Recurrent Duodenal Ulcer", 1988
    47 84
    4.28 "Methodological Considerations in the Analysis of Cost-effectiveness in Dentistry", 1989
    47 85
    4.29 "Chimiotherapie Adjuvante du Cancer Colorectal; qu' apprendre d'une Meta-analyse?"
    47 86
    4.32 "Publication Bias: A Problem in Interpreting Medical Data", 1988
    47 87
    4.33 "Publication Bias and Dissemination of Clinical Research", 1989
    47 88
    4.34 "A Comparison of Statistical Methods for Combining Event Rates from Clinical Trials", 1989
    47 89
    4.35 "The Effect of Study Design on Gain in Evaluations of New Treatments in Medicine and Surgery", 1988
    47 90
    4.36 "How Study Design Affects Outcomes in Comparisons of Therapy: I Medical", 1989
    47 91
    4.37 "How Study Design Affects Outcomes in Comparisons of Therapy: II Surgical", 1989
    47 92
    4.38 "Randomized Clinical Trials of Transdermal Nitroglycerin Systems for the Treatment of Angina: A Meta-analysis", 1988
    47 93
    4.39 "The Role of Clinical Trials in Healthcare: A Personal View", 1988
    47 94
    4.40 "Retrospective Analyses for Hypothesis Generation: A Commentary on the PACK Trial", 1989
    47 95
    4.42 "The Quality of Primary and Secondary Research and Meta-analysis", 1989
    47 96
    4.43 "Meta-analysis of Branched-chain Amino Acids in Hepatic Encephalopathy (Editorial)", 1989
    47 97
    4.44 "A Review of Clinical Research in Orthodontics", 1989
    47 98
    4.45 "Meta-analyses in Gastroenterology", 1989
    47 99
    4.46 "Symposium: Clinical Applications of Meta-analysis", 1989
    47 100
    4.47 "Meta-analytic Evidence Against Prophylactic Use of Lidocaine in Acute Myocardial Infarction", 1989
    47 101
    4.49 "A Cohort Study of Summary Reports of Controlled Trials", 1990
    47 102
    4.52 "Updated (Cumulative or Sequential) Meta-analyses of Histamine (H2) - Blockers in the Treatment of Bleeding Peptic Ulcers", 1990
    47 103
    4.54 "Some Statistical Methods for Combining Experimental Results", 1990
    47 104
    4.55 "The Need for Early Randomization in the Development of New Drugs for AIDS", 1990
    47 105
    4.57 "Split-mouth and Cross-over Designs in Dental Research", 1989
    47 106
    4.58 "Quality Assessment and Meta-analysis of Systemic Tetracycline Use in Chronic Adult Periodontitis", 1992
    47 107
    4.59 "Problems Induced by Meta-analysis", 1991
    47 108
    4.60 "A Meta-analysis of Physical Activity in the Prevention of Coronary Heart Disease", 1990
    47 109
    4.61 "An Empirical Study of the Possible Relation of Treatment Differences to Quality Scores in Controlled Randomized Clinical Trials", 1990
    47 110
    4.62 "Measuring Outcomes in Clinical Research", 1991
    47 111
    4.63 "Using Medical Registries and Data Sets for Technology Assessment", 1991
    47 112
    4.64 "Technology Assessment in the Connecticut Tumor Registry", 1991
    47 113
    4.65 "Use of the SEER Cancer Registry for Technology Assessment", 1991
    47 114
    4.66 "Technology Assessment in the Normative Aging Study", 1991
    47 115
    4.67 "Technology Assessment in the Veterans Administration Dental Longitudinal Study", 1991
    47 116
    4.68 "Technology Assessment in the Coronary Artery Surgery Study", 1991
    47 117
    4.69 "Using Medical Registries and Data Sets for Technology Assessment: An Overview of Seven Case Studies", 1991
    47 118
    4.71 "Meta119-analysis and Quality Assessment of Local Tetracycline use in Treatment of Chronic Adult Periodontitis", 1991
    47 119
    4.72 "Update on Technology Assessment in Dentistry", 1992
    47 120
    4.74 "Economic Analysis in Randomized Control Trials", 1992
    47 121
    4.75 "A Comparison of Results of Meta-analyses of Randomized Control Trials and Recommendations of Clinical Experts", 1992
    47 122
    4.76 "Cumulative Meta-analysis of Therapeutic Trials for Myocardial Infarction", 1992
    47 123
    4.79 "Assessment of the Efficacy and Safety of Antiarrhymic Therapy for Chronic Atrial Fibrillation: Observations on the Role of Trial Design and Implications of Drug-related Mortality", 1990
    47 124
    4.80 "Some Progress and Problems in Meta-analysis of Clinical Trials", 1992
    47
    Books and Chapters, Technology Assessment Group, Harvard School of Public Health, 1954-1991 [subseries]:
    47 125
    6.1 "Selected Quantitative Techniques", 1954
    47 126
    6.2 "Assessing Social Innovations: An Empirical Base for Policy", 1975
    47 127
    6.3 "How Well do Social Innovations Work?", 1975
    47 128
    6.4 "How Frequently Do Innovations Succeed in Surgery and Anesthesia?", 1977
    47 129
    6.5 "Progress in Surgery and Anesthesia: Benefits and Risks of Innovative Therapy"
    47 130
    6.6 "Combination of Results of Stated Precision: I. A More Realistic Case", 1984
    47 131
    6.7 Medical Uses of Statistics
    47 132
    6.8 "A Computer-driven Shift in the Practice of Medicine", n.d
    47 133
    6.9 "Clinical Trials of Treatment", 1986
    47 134
    6.10 "The Randomized Control Trials of Prevention of Myocardial Infarction", 1986
    47 135
    6.11 "Meta-analysis as Applied to Post-marketing Surveillance", 1987
    47 136
    6.12 "Randomized Control Trials and Meta-analysis of the Treatment of Cirrhosis of the Liver", 1987
    47 137
    6.13 "Hormone Therapy for the Maintenance of Pregnancy"
    47 138
    6.14 "Clinical Trials", 1988
    47 139
    6.18 "The Evaluations of Surgical Therapies", 1989
    47 140
    6.22 "Who is Interested in Clinical Trials? The Potential for and Methods of Minimizing Bias in Funded Research", 1991
    47
    Papers Submitted for Publication or in Press, 1990-1995 [subseries]:
    47 141
    7.1 "Declining Incidence of Ventricular Fibrillation", 1992
    47 142
    7.3 "Reporting the Results of Observational Studies: The Nutrition and Periodontal Disease Relationship"
    47 143
    7.6 "Patient Controlled Analgesia in the Postoperative Patient: Meta-analysis of Initial Randomized Control Trials", 1992
    47 144
    7.8 "Antipsychotic Drugs: Is More Worse? A Meta-analysis of the Published Randomized Control Trials", 1990
    47 145
    7.12 "The Design, Analysis, and Reporting of Research: Findings from Meta-analysis", 1990
    47 146
    Chalmers Bibliography, 1993
    47 147
    Reprints, 1992-1995
    47
    Series 5: Conferences, 1983-1991 [series]:

    This series contains correspondence, notes, information packets, schedules, and travel documents relating to the various conferences Chalmers attended during the 1980s and early 1990s. The series is arranged alphabetically by file folder.

    47 148
    54th Scientific Meeting, American College of Rheumatology, Seattle, Washington, 10/8-11/1, 1990
    47 149
    62nd Scientific Sessions, 1986-1989
    47 150
    Acapulco, 6/19-22, 1989
    47 151
    Agency for Health Care Policy and Research, Chicago, 6/20-21, 1991
    47 152
    Agency for Health Care Policy and Research, Moshman Associates, 7/11, 1990
    47 153
    AIDS, Washington, D.C., 11/19-21, 1989
    47 154
    American Association for the Advancement of Science, Annual Meeting, 2/15-16, 1990
    47 155
    American College of Surgeons, 10/8, 1990
    47 156
    American Medical Association, Technology PD, 10/28, 1988
    47 157
    Association of American Physicians, American Society of Clinical Investigations, American Federation for Clinical Trials, Washington, D.C., 4/28-5/1, 1989
    47 158
    Barcelona, 1990
    47 159
    China, April, 1983
    47 160-162
    Collegium Ramazzini, Italy, 1986-1991
    47 163
    Coolfont Conference, Environmental Epidemiology Committee, MAS, Virginia, 10/14-17, 1990
    47 164
    Copy of Washington, D.C. Trip, 1/14-15, 1988
    47 165
    D.C. - Chicago - D.C. - Iowa City, 11/12-18, 1988
    47 166
    Dallas, 4/14-15, 1988
    47 167
    Data Training Workshop Papers, BWI Airport, 1990
    47 168
    Hans Popper, New Concepts in Medical Biology, December, 1988
    47 169
    IMA GO 90, Bologna, Italy, 4/27-29, 1989
    47 170
    Innsbruck, Rome, Corsendonck, August- September, 1988
    47 171
    Institute of Medicine, May 3-June 9, 1989
    47 172
    Institute of Medicine, PO Effectiveness, 1988
    47 173
    International Biometric Conference, Brussels, Belgium, 7/7-11, 1987-1988
    47 174-176
    International Physicians for the Prevention of Nuclear War, Inc., Montreal (includes transparencies for Katherine Forrest), 1988
    47 177
    Interplan Germany, 1988
    47 178-179
    Iowa City, 1988
    48 1
    Iowa City, 1988
    48 2
    ISI, Paris, France, 8/29-9/6, 1989
    48 3
    Jassen Research Council, WASL FIB, 1988
    48 4-5
    Madrid, 1990
    48 6
    Minnesota Colon Cancer Study, 10/13-14, 1988
    48 7
    Montreal General Hospital, PD, 9/23, 1988
    48 8
    National Institutes of Health, Bethesda, MD, 10/18, 1989
    48 9
    Office of Medical Applications of Research, National Institutes of Health, Meetings on Clinical Trials, 1989-90
    48 10-11
    Port, Agency for Health Care Policy and Research, Baltimore, 1990
    48 12
    Posch, Chicago, O'Hare, 1988
    48 13
    Rochester, Minnesota Meeting, 5/21-23, 1989
    48 14
    San Francisco P., 2/13-15, 1988
    48 15
    Schedule and Correspondence, 1988-1989
    48 16-17
    Seattle, WA, 1989-1991
    48 18
    Society for Clinical Trials, Minneapolis, Minnesota, 5/15-18, 1989
    48 19
    Society of Salk Scholars 3rd Annual Scientific Conference, 10/26, 1990
    48 20
    Taiwan, Clinical Trials Imaging Procedures, 1983
    48 21
    The Southern Society for Pediatric Research, New Orleans, 2/3-5, 1988
    49 1
    Toronto, 1989
    49 2
    U. Gastroenterology International, Washington, D.C., 5/14, 1989
    49 3
    University of Texas Health Science Center at Dallas Medical School, Dallas, 4/14-15, 1988
    49 4
    Veterans Administration, Chicago, 1983
    49 5
    Washington, Katanserin, 3/14, 1988
    49 6
    Washington, National Leadership, PD, 3/18, 1988
    49 7
    World Congress of New Castle, New Castle, Australia, 8/29, 1990
    Series 6: Audiotapes, 1963 [series]:

    This series contains two reel-to-reel audiotapes. Documentation on the tapes is poor with one tape lacking any documentation. The "Pathogenesis and Medical Treatment of Ascites Thomas C. Chalmers... " tape also contains lectures by various other speakers; a table of contents is included.

    49 8
    "Pathogenesis and Medical Treatment of Ascites" Thomas C. Chalmers, Internal Medicine, Vol. 10, Number 19, 10/7/1963
    49 9
    Untitled [open reel]