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National Library of Medicine

Finding Aid to the Edward D. Freis Papers1926-2004

Archives and Modern Manuscripts Program, History of Medicine Division
Processed by Michele M. Tourney
Processing Completed March 2005
Encoded by Michele M. Tourney


Summary Information
Title: Edward D. Freis Papers
Creator: Freis, Edward D.
Dates: 1926-2004
Extent: 18.3 linear feet (21 boxes)
Abstract:
A pioneer in the study of hypertension, Edward D. Freis, M.D., is best known for leading the 5-year Veterans Administration Cooperative Study on Antihypertensive Agents which proved the value of antihypertensive drugs in decreasing morbidity and mortality; this study was the first multi-clinic, double-blind, randomized, placebo-controlled trial of its kind. Freis's collection of articles, photographs, scrapbooks, and subject files chronicle his sixty-year career in the study of hypertension and hemodynamics.

Call number: MS C 550
Language: Collection materials primarily in English
Location: Materials stored onsite. History of Medicine Division. National Library of Medicine

Access Restrictions:

Portions of the collection are restricted according to HMD's Access to Health Information of Individuals policy. Contact the Reference Staff for information regarding access. For access to the policy and application form, please visit https://www.nlm.nih.gov/hmd/manuscripts/phi.pdf.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Freis, Edward D. Edward D. Freis Papers. 1926-2004. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 550.

Processing Information

The original pressure bindings were removed from the scrapbooks in Series 2 during processing and the contents re-housed; photocopies were made of Scrapbooks 1 and 39 (Freis's retirement) prior to disbinding to preserve the original context. Photocopies on acid-free paper have replaced the original newspaper clippings. An investigator's brochure from Series 5 was removed from its 3-ring binder and the contents re-housed.

Alternate Forms Available:

Portions of the Collection have been digitized and are available at: http://profiles.nlm.nih.gov

Provenance:

Gift, Edward D. Freis, 10/19/2004. Acc. #2004-056.


freis550Finding Aid to the Edward D. Freis Papers, 1926-2004Archives and Modern Manuscripts Program, History of Medicine Division1.0History of Medicine Division, National Library of Medicine.
8600 Rockville Pike
Bethesda, Maryland, 20894
USA
Phone: (301) 402-8878 (Reference Desk)
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Machine-readable finding aid encoded by Michele M. TourneyFinding aid is written in English

National Library of Medicine

Finding Aid to the Edward D. Freis Papers1926-2004

Archives and Modern Manuscripts Program, History of Medicine Division
Processed by Michele M. Tourney
Processing Completed March 2005
Encoded by Michele M. Tourney

Descriptive Summary

Freis, Edward D.Edward D. Freis Papers Dates: 1926-200418.3 linear feet (21 boxes)MS C 550 Materials stored onsite. History of Medicine Division. National Library of Medicine Collection materials primarily in EnglishAbstract:A pioneer in the study of hypertension, Edward D. Freis, M.D., is best known for leading the 5-year Veterans Administration Cooperative Study on Antihypertensive Agents which proved the value of antihypertensive drugs in decreasing morbidity and mortality; this study was the first multi-clinic, double-blind, randomized, placebo-controlled trial of its kind. Freis's collection of articles, photographs, scrapbooks, and subject files chronicle his sixty-year career in the study of hypertension and hemodynamics.Provenance:

Gift, Edward D. Freis, 10/19/2004. Acc. #2004-056.

Access Restrictions:

Portions of the collection are restricted according to HMD's Access to Health Information of Individuals policy. Contact the Reference Staff for information regarding access. For access to the policy and application form, please visit https://www.nlm.nih.gov/hmd/manuscripts/phi.pdf.

Copyright and Re-use Information

Donor's copyrights were transferred to the public domain. Archival collections often contain mixed copyrights; while NLM is the owner of the physical items, permission to examine collection materials is not an authorization to publish. These materials are made available for use in research, teaching, and private study. It is the user's responsibility to research and understand any applicable copyright and re-publication rights not allowed by fair use. NLM does not grant permissions to publish.

Privacy Information

Archives and manuscript collections may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in any collection without the consent of those individuals may have legal ramifications for which the National Library of Medicine assumes no responsibility.

Preferred Citation:

Freis, Edward D. Edward D. Freis Papers. 1926-2004. Located in: Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine, Bethesda, MD; MS C 550.

Alternate Forms Available:

Portions of the Collection have been digitized and are available at: http://profiles.nlm.nih.gov

Processing Information

The original pressure bindings were removed from the scrapbooks in Series 2 during processing and the contents re-housed; photocopies were made of Scrapbooks 1 and 39 (Freis's retirement) prior to disbinding to preserve the original context. Photocopies on acid-free paper have replaced the original newspaper clippings. An investigator's brochure from Series 5 was removed from its 3-ring binder and the contents re-housed.

Separated Material

  • Nutrition and the Killer Diseases (1981)
  • Perspectives in Cardiovascular Research, Vol. 4: Prophylactic Approach to Hypertensive Diseases (1979)
  • Systemic Effects of Antihypertensive Agents (1976)
  • Robinson, Donald - The Miracle Finders (1976)
  • Hypertension and the Cardiovascular System (1972)
  • Moser, Marvin - The Treatment of Hypertension: A Story of Myths, Misconceptions, Controversies and Heroics (2002)
  • Pickering, Thomas - Good News about High Blood Pressure (1996)
  • Freis. The High Blood Pressure Book: a Guide for Patients and Their Families (1979)
  • Freis. Cardiology Reference Book (1980)
  • Freis. Introduction to the Nature and Management of Hypertension (1974)
  • Comroe, Julius. Retrospective: insghts into medical discovery (1977)
  • Ruskin, Arthur. Classics in arterial hypertension (1956)
  • Diem, Konrad, ed. Scientific tables (1962)
  • Cannon, Walter. The way of an investigator (1945)
  • Glasser, Otto. Medical physics (1944)
  • Hales, Stephen. Statistical essays, containing haemastaticks (1981)
  • Pickering, Thomas. High blood pressure (1968)
  • Brod, Jan. The kidney (1973)

Biographical Note

Edward David Freis (1912-2005) was born in Chicago, Illinois on May 13, 1912, one of four sons of Roy and Rose (Goldstein) Freis. He attended school in Chicago, graduating from Nicholas Seen High School in 1930, and earned his Bachelor of Science degree from the University of Arizona in 1936. He married Willa Irene Hussey on August 12, 1936, after they met in college. They had three children before eventually divorcing around 1974; the two remained close until Willa's death in 1999. A year after the divorce, Freis met Mary Rose Curtis, the woman who would be his companion for the last thirty years of his life.

Continuing his education at Columbia University's College of Physicians and Surgeons, Freis earned his M.D. in 1940. He interned at Massachusetts Memorial Hospital in Boston from 1940 to 1942, serving as House Physician of the 5th Medical Service of Boston University at Boston City Hospital from 1941 to 1942. When the United States entered into World War II Freis joined the U.S. Air Force and served at Lincoln Air Force Base in Nebraska as Assistant Chief and Chief of Laboratory Services from 1942 until 1944. He then became Chief of Laboratory Service in the Rheumatic Fever Research Program at Gowen Field in Boise, Idaho.

After leaving the armed services in 1945, Freis returned to Boston for a cardiology residency at Evans Memorial Hospital from 1946 to 1947, and afterwards held the position of Research Fellow for two years. While at Evans, Freis authored his first article on the benefits of using drugs in fighting the effects of hypertension. In addition to this work at the hospital, he taught at Boston University of Medicine as an Instructor of Medicine.

Freis's growing interest in the study of hypertension led him away from Boston to a joint appointment at the Veterans Administration Hospital and Georgetown University School of Medicine in Washington, DC in 1949; there he would build his reputation and remain for the rest of his career. From 1949 to 1959, Freis served as Assistant Chief and then Chief of Medical Service at the V.A. Hospital, and taught at the Georgetown University Medical Center. A year after joining the faculty, he established the Hypertension Clinic at the Medical Center and served as its chief for ten years from 1950 to 1960. Beginning in 1957 he investigated the first orally effective diuretic, an agent called chlorothiazide. His work led to a promotion in 1959 to Senior Medical Investigator. It was in this capacity that Freis would make his greatest contribution to the study of hypertension: he set out to prove his theories that hypertension was a cause of heart attacks, strokes, and kidney failure, and not merely a symptom of underlying vascular disease.

In 1964 Freis and his researchers at the Veterans Administration designed and led the Veterans Administration Cooperative Study Group on Antihypertensive Agents. This five-year study, which involved 17 hospitals and over 500 patients, was the first multi-clinic, double-blind, randomized, placebo-controlled trial of its kind. Freis and his colleagues based the structure of this new study on a similar trial in antituberculosis research at the V.A., and while it was a continuation of sorts of earlier antihypertensive studies, the initial goals of the trial were to determine the potency of certain antihypertensive drugs. In particular, the researchers looked at occurrences of morbidity and mortality in cases of moderate to severe hypertension. The results of this undertaking confirmed Freis's belief that even moderate hypertension could be deadly, and that treatment through drug therapy could reduce the death rate and help prevent the development of serious complications such as stroke, congestive heart and kidney failure.

Little fanfare accompanied the release in 1970 of the study's results, until Freis was awarded the Albert Lasker Foundation Clinical Research Award in 1971 for his role in the V.A. Cooperative Study. Mary Lasker of the Foundation was so convinced of the findings that she brought them to the attention of the National Institute of Health's Secretary of Health, Education, and Welfare Elliot Richardson; shortly thereafter in 1972 he established the High Blood Pressure Education Program under the auspices of the National Heart, Lung, and Blood Institute. The relative success of this first cooperative study laid the groundwork for many subsequent studies, many headed by Freis in his role as Senior Medical Investigator.

Throughout his long career, Freis actively participated in professional organizations such as the American Heart Association and the American Medical Association. He served on the editorial boards of several medical journals including Circulation and American Heart Journal. He has been recognized numerous times for his work, receiving the CIBA Award for Hypertension Research from the American Heart Association in 1981, and the first ever Stevo Julius Award for Education in Hypertension from the International Society of Hypertension in 2000. The National Conference on High Blood Pressure Control named an award after him in 1985.

Having received recognition for his contributions to the study of hypertension, Freis continued to work as a Distinguished Physician with the Veterans Administration until his death at 92 in February 2005. He had authored several books and chapters, countless lectures, and nearly 400 articles in medical journals worldwide. One of his most important articles, however, appeared early in his career: his "Hemodynamics of Hypertension," published in Physiological Reviews in 1960, drew attention to the relationship between circulation and hypertension. Many today consider this to be a classic text in basic hypertension; some of his colleagues rank this article with his V.A. study in terms of contribution to cardiovascular research.

Brief Chronology

1912Born Edward David Freis in Chicago, Illinois (May 13)
1936Receives B.S., University of Arizona. Marries Willa Irene Hussey (August 12); they have 3 children and eventually divorce (ca. 1974)
1940Receives M.D., Columbia University College of Physicians and Surgeons
1940-1942Internship, Massachusetts Memorial Hospital in Boston
1941-1942House Physician, 5th Medical Service of Boston University, Boston City Hospital
1942-1944Assistant Chief and Chief of Laboratory Service, U.S. Air Force (Lincoln Air Force Base, Lincoln, Nebraska)
1944-1945Chief of Laboratory Service, Rheumatic Fever Research Program (Gowen Field, Boise, Idaho)
1946-1947Assistant Resident in Medicine, Evans Memorial Hospital (Boston, Massachusetts)
1946-1949Instructor in Medicine, Boston University of Medicine
1947-1949Research Fellow, Evans Memorial Hospital
1949-1954Assistant Chief, Medical Service, Veterans Administration Hospital (Washington, DC)
1949-1957Adjunct Clinical Professor of Medicine, Georgetown University Medical School
1949-1965Director, Cardiovascular Research Laboratory, Georgetown University Medical Center
1950-1960Chief, Hypertension Clinic, Georgetown University Medical Center
1954-1959Chief, Medical Service, Veterans Administration Hospital
1957-2005Professor of Medicine, Georgetown University Medical Center emeritus, ca. 2000-2005
1957Studies first orally effective diuretic, chlorothiazide
1959-1987Senior Medical Investigator, Veterans Administration Hospital
1960Publishes "The Hemodynamics of Hypertension"
1968Made Fellow in American College of Physicians
1964-1970Designs and leads the first double-blind, placebo-controlled, multi-clinic randomized study of drug efficacy in hypertension: the Veterans Administration Cooperative Study on Antihypertensive Agents. Forms basis for subsequent hypertension studies.
1971Receives Albert Lasker Foundation Clinical Research Award
1979Receives first Distinguished Service Award from Editorial Board of Dialogues in Hypertension
1981Receives CIBA Award for Hypertension Research, American Heart Association
1985Receives honorary Doctor of Science, Georgetown University Medical Center; National Conference on High Blood Pressure Control names award after him
1987-2005Distinguished Physician, Veterans Administration Medical Center, and Professor emeritus, Georgetown University Medical Center
2000Receives the first Stevo Julius Award for Education in Hypertension
2005Dies February 1 at age 92



Journal articles and reprints, books, subject files, research data, photographs, slides, and videotapes (1926-2004; 18.3 linear feet) chronicle the work of Edward D. Freis as a pioneer in the research of hypertension and hemodynamics. As a senior medical investigator at the Hypertension Research Clinic, Veterans Affairs Medical Center, Freis conducted many clinical trials that led to the development of more effective treatments for hypertension. However, the collection lacks much of the original clinical data collected during his research; if this data survives they would most likely remain at the V.A. Medical Center.

His clinical research and overall expertise on hypertension are best represented in Series 3: Writings and Lectures and Series 5: Studies. Freis wrote nearly 400 articles on all aspects of hypertension; the majority of the materials in Series 3 are reprints of articles written by Freis and his colleagues. Several typescripts of his articles are also contained within this series, as are several books on hypertension authored by Freis. Series 5 contains some materials regarding studies with which Freis was involved; these items include "investigator's brochures" (compiled data), study proposals, a final draft from the landmark V.A. Cooperative Study on Antihypertensive Agents, and some illustrative materials such as graphs and photographs.

In addition to his own reprints, Freis gathered reprints and photocopies of articles and essays by others, which he annotated and supplemented with his own notes, research data, and other materials (Series 4: Subject Files). Freis organized these files into three main subject areas: Hypertension, Hemodynamics, and Miscellaneous; he also created a detailed index to the scheme. Each main subject was given a unique letter designation: H for hypertension, T for hemodynamics, and U for Miscellaneous. Subsets within each main category were numbered in ascending order, while the individual component folders were numbered in descending order (usually beginning with 34). These numbers are found within square brackets. The index contains missing file numbers, presumably by intent and to be filled in later. During processing, unclassified files were arranged alphabetically in the subseries Subjects Not Filed by Freis; when missing, titles were supplied and marked by square brackets.

Also included in the Writings and Lectures series are audio recordings, videotapes, and transcripts of medical lectures and interviews given by Freis throughout his career to various audiences. Many of the videotapes were dubbed in the late 1980s from the original films, whose locations are unknown. One videotape, "Early Hypertension TV Broadcasts," contains lectures for the American College of Physicians (1954) and the CIBA TV Clinical Symposium (1959) whereby the audience watched the speaker through closed circuit television, making them a novel presentation method for that period in time.

The collection contains little personal information about Freis apart from the scrapbooks that comprise Series 2. The scrapbooks themselves contain article reprints, some photographs, some correspondence, and programs from conferences, symposia, award ceremonies, etc. at which Freis participated or attended and are arranged chronologically. While most of the scrapbooks profile Freis's career, the next to last album in the series pertains to his retirement from the Veterans Administration; the contents consist of letters of congratulations from friends and colleagues (including Walter Mondale), as well as photographs from the farewell dinner.

In addition to the scrapbook materials, Series 1: Personal and Biographical includes CVs and bibliographies from various points in Freis's career, including a recent one from 2001. A few items document the numerous awards received by Freis, although some of the actual awards are contained within this series. Also of interest are several of Freis's golf diaries that range in date from the 1970s until just a few years before his death. A handful of portrait photographs of Freis are included among the photographic materials in Series 6, however the bulk of the series contains illustrations for lectures and articles. The slides appear to have been used by Freis during lectures and for some of his publications. He mixed and matched slides to create different lectures and others were pulled to be used in publications; they are arranged loosely by topic when possible.

Index Terms

These terms are indexed in the National Library of Medicine's online catalog LocatorPlus. Researchers wishing to find related materials should search the catalog using these terms.

    MeSH Subjects

    • Antihypertensive Agents
    • Clinical Trials
    • Hemodynamics
    • Hypertension
    • Vascular Diseases
    Personal Names

    • Freis, Edward D.
    Corporate Names

    • Georgetown University
    • VA Medical Center (Washington, D.C.)

    Series Descriptions

    Series 1: Personal and Biographical, 1969-2002 Resumes, CVs, Bibliographies, 1974-200111Who's Who biographical data form, 197412 CV, ca. 197913 CV and bibliography, 1998-200114 CV, 2002 Awards, 1992-200215 Lasker Award [program, clippings, etc.], 197116 Howard Blakeslee Award, [1980]17 Nobel Peace Prize nomination [correspondence], 199218 Stevo Julius Award, 200019 American Heart Association Award of Achievement [correspondence], 2001222 Plaque of appreciation, Veterans Administration Study, [ca. 1970]223 Oscar B. Hunter Award, American Society for Clinical Pharmacology and Therapeutics [plaque], 1972224 Medical Science Achievement Award, American Heart Association [plaque], 1984110 Department of Veterans Affairs Exemplary Service Award, 2002 Medical Licenses and Memberships, 1940-51111 New York Academy of Sciences membership certificate, 1951221 Massachusetts state medical license, 1948221 Massachusetts Medical Society membership certificate, 19492110 New York state medical license, 1940112-15 Golf Diaries, 1977-98116 Correspondence, Professional Organizations, 1997-2000117 Correspondence, Personal, 1981219 Pencil drawing of Freis, 19772vols.Grand Rounds, Georgetown University School of Medicine [2 volumes], 1969, 1982 Presentation volumes2vol. Freis. The High Blood Pressure Book, 19793vol.Angiology, The Journal of Vascular Diseases, vol. 11 [award copy], 19603vol. Stapleton, John F. Upward Journey: the Story of Internal Medicine at Georgetown, 1851-1981, 19963vol. Page, Irvine H. Hypertension Research: a Memoir 1920-1960, 19883vol.Hypertension Update: Mechanisms, Epidemiology, Evaluation, Management, 1980 Series 2: Scrapbooks, 1926-200441 Scrapbook 1, 1926-6142-3 Scrapbook 2 [photographs], 1942-5344-8 Scrapbook 3, 1942-5949-10 Scrapbook 4, 1952-58411-12 Scrapbook 5, 1953-57413-14 Scrapbook 6, 1954-59415-17 Scrapbook 7 [photograph], 1959-61418-19 Scrapbook 8 [photograph], 1959-61420-21 Scrapbook 9, 1960-61422-25 Scrapbook 10 [photographs], 1961-72426-28 Scrapbook 11 [photographs], 1962-65429-31 Scrapbook 12 [photographs], 1965-72432-33 Scrapbook 13 [photographs], 196651-2 Scrapbook 14 [photographs], 1967-6853-5 Scrapbook 15 [photographs], 1967-7056-8 Scrapbook 16 [photographs], 1969-197159-11 Scrapbook 17 [photographs], 1970-74512-14 Scrapbook 18 [photographs], 1970-74515-17 Scrapbook 19 [photographs], 1970-79518-21 Scrapbook 20 [photographs], 1971-72522-23 Scrapbook 21 [photographs], 1971-76524-25 Scrapbook 22 [photographs], 1972526-29 Scrapbook 23 [photographs], 1973530-31 Scrapbook 24 [photographs], 1974532-34 Scrapbook 25 [photographs], 197461-3 Scrapbook 26 [photographs], 1975-7664 Scrapbook 27 [photographs], 1975-7665-6 Scrapbook 28 [photographs], 1976-7767-8 Scrapbook 29 [photographs], 1976-7769-10 Scrapbook 30 [photographs], 1978-79611-13 Scrapbook 31 [photographs], 1978-81614-15 Scrapbook 32 [photographs], 1979-80616-18 Scrapbook 33 [photographs], 1980-85619-20 Scrapbook 34 [photographs], 1980-85621-22 Scrapbook 35 [photographs], 1981-82623-24 Scrapbook 36, 1982625-26 Scrapbook 37, 1982-83627-28 Scrapbook 38, 1982-88629-38 Scrapbook 39 - Freis' retirement [photographs], 1986-87639-40 Scrapbook 40 [photographs], 1990-2004 Series 3: Writings, Lectures and Public Appearances, 1942-2002 Correspondence, 1993-200071 Adis International, 1993-9772Archives of Internal Medicine, 199973Comprehensive Therapy, 200074Hypertension and Le Jacq Communications, 199775 Perry, Mitch, 200076 Abstracts, 1975-86 Freis reprints, 1942-200177 A - Al, 1949-9278 An - As, 1950-8679 B, 1949-86710 Ca - Ch, 1958-86711 Cl, 1942-77712 Col - Com, 1943-86713 Con - Cu, 1957-89714 D, 1954-85715 Ea - Effect (S), 1947-85716 Effect (T) - Effects (R), 1953-1989717 Effects (S - V), 1955-1974718 Effi - Es, 1944-1983719 Ev - Ex, 1950-1972720 F - G, 1960-79721 Ha - Hemodynamic (C), 1951-79722 Hemodynamic (E - T), 1949-82723 Hemodynamics - Hypertension (A), 1960-95724 Hypertension (C - Q), 1956-77725 Hypertension (R) - Hypertensive, 1962-93726 I - L, 1944-86727 Ma - Med (E), 1955-78728 Med (R) - Mu, 1949-84729 Na, 1972730 Ne - No, 1974-83731 O, 1949-93732 Pa - Pra, 1948-89733 Pre, 1960-84734 Pri - Pro, 1970-94735 Ra - Rec, 1948-90736 Rel - Res, 1944-95737 Ret - Ro, 1960-92738 Sa - Si, 1947-93739 So - Sy, 1949-2001740 Th - Tre (E), 1953-88741 Tre (H - L), 1952-91742 Tre (M) - Tri, 1944-8281 U - Va, 1952-9282 Ve - W, 1951-2001 Typescripts and Proofs, 1963-200083 "Combined L-Alpha Methyl DOPA and Sulfonamide Diuretic Therapy of Hypertension" [photographs], 196384 "Current Drug Treatment for Hypertension", 199985 "Current Status of Diuretics, Beta-Blockers, Alpha-Blockers, and Alpha-Beta-Blockers in the Treatment of Hypertension", 199686 "Diuretics and the Latest JNC Report", 199587 "Dose Response Curve for Hydrochlorothiazide in Essential Hypertension", 198988 "Double-Blind Assessment of Tienilic Acid in Essential Hypertension" [photographs], [1979]89 "Drug Lag" [Letter to the editor of JAMA], 1975810 "Fixed-Dose Two-Drug Combinations for the Treatment of Hypertension", 2000811 "Improving Treatment Effectiveness in Hypertension", 2001812 "Increased Mortality Among Young Black Hypertensive Veterans from the 'Stroke Belt'", ca. 1990813 "Influence of the Adrenergic System in Renovascular Hypertension" [photographs], [1971]814 "Influence of the Sino-Aortic Reflexes on the Control of Arterial pH, Po2, and Pco2 during Wakefulness and Sleep" [photographs], 1969815 "Making Antihypertensive Drug Treatment More Effective", ca. 1999816 "Mechanism of Antihypertensive Effect of Thiazide Diuretics", [1978]817 "Methodology of Multiclinic Therapeutic Trials in Hypertension", [1967]818 "Prognosis in Elderly Hypertensive Patients", 1993-94819 "Role of Left Ventricular Hypertrophy in Essential Hypertension", [ca. 1980]820 "The Role of Salt in Hypertension", 1992821 "Sodium Deprivation as an Approach to Hypertension", [1981]822 "The Treatment of Hypertension: Why, When, and How", [1972]823 "Venomotor Control and Cardiac Preload", 1993824 "The Veterans Administration Therapeutic Trial in Hypertension", [ca. 1973]825 "The Veterans Administration Trial" [photographs], 1998-99 Lectures, Interviews, Testimonies, Appearances, 1954-98 Transcripts91 "Development of the Salt-Volume Concept in Hypertension" [transcript and slides], ca. 197592 "Hydraulics of Hypertension: New Insights for Patient Management" [lecture outline with slides], 197993 Oral history interview with Dr. Freis conducted by Dr. Marvin Moser [transcript], 199894 Testimony of panel of medical investigators, National Academy of Sciences Study of Health Care for American Veterans and the VA Response, 1978 Audio Recordings10 "Clinical Practice of Cardiology: Modern Pharmacological Management of Systemic Hypertension" [audio cassette with slides]10 "Drs. Fries [sic] and Smith: Hypertension" [audio cassette]10Internal Medicine vol. 7 no. 2: "Symposium on the Hypertensive State" [magnetic tape reel], 1960 Jan 1810Internal Medicine vol. 7 no. 3: "Symposium on the Hypertensive State, Part II" [magnetic tape reel], 1960 Feb 110Internal Medicine vol. 8 no. 24: "Atherosclerosis and Hypertension: Renal Vascular Hypertension" [magnetic tape reel], 1961 Dec 2510 News Conference on Results of Coop. Study [magnetic tape reel], 1970 Aug 1710 "Today's Therapeutics with Walter Modell: Hypertension" [audio cassette], 197210 "New Directions in Hypertension, vol. 1: Grand Rounds" [audio cassette], 197310 "Hypertension Reporter, vol. 2: Practical Problems in the Office Management of Hypertension" [audio cassette], 197410 "Hypertension Hotline, Houston Texas" [audio cassette], 1974 May 14-1510 "Hypertension Reporter #12, Sides A & B, Synthesis Communications / Freis and Materson" [audio cassette], 197810 "[Dr. Freis's] talk in Miami", 1980 Mar 1310 "Dr. Fries [sic] and Dr. Moser interview on hypertension" [audio cassette], 1996 Apr 810 "personal journeys: conversations with people of special dedication" [audio cassette], [1997] Video recordings11 "Early Hypertension TV Broadcasts": American College of Physicians; CIBA TV Clinical Symposium [VHS tape], 1954, 195911 "Medcom Lecture: Clinical Management of Hypertension" [VHS tape], ca. 197511 "Beta-Adrenergic Blockade TV Symposium, Part I" [3/4" tape], 1977 Oct 411 "War Against Hypertension" [VHS tape], 198711 "VA Coop. Study Media Coverage / Dr. Edward Freis" [VHS tape], 1993 Apr Writings about Freis's work, 1952-200295 Davis, Maxine. "Hypertension," Good Housekeeping, 1952 May218 Silverman, Milton. "It knocks down high blood pressure," The Saturday Evening Post, 1952 July 1296 de Kruif, Paul. "Rauwolfia Against High Blood Pressure," Reader's Digest, 1954 Aug211 Pearse, Ben. "The Pill with the Built-In Surprise," The Saturday Evening Post, 1958 Oct 497 Contemporaries: Edward D. Freis, M.D., Modern Medicine, 1962 Nov98 Galton, Lawrence. "High Blood Pressure: New Light on a Hidden Killer," Reader's Digest, 1971 Jun99 Stoler, Peter and Jean Bergerud. "Hypertension: Conquering the Silent Killer," Time, 1975 Jan 13217 Bloom, Hugh. "Men who changed therapeutics: Dr. Edward D. Freis, proving the value of antihypertensive therapy," Therapies, 1979 May 12910 Moore, Thomas J. "How Doctors Oversell the Risks of High Blood Pressure," Washingtonian, 1990 Aug911 Moser, Marvin. Myths, Misconceptions, and Heroics: the Story of theTreatment of Hypertension from the 1930's, 19979 Research works, by others, 1950-2001912American Journal of Hypertension, vol. 10, no. 7, pt. 2, 1997 Jul913Drugs, vol. 1, suppl. 1, 1976914Emergency Department: Rapid Identification and Treatment of Patients with Acute Myocardial Infarction [NIH Publication No. 93-3278], 1993 Sep915Hypertension: Proceedings of the Council for High Blood Pressure Research, vol. XI, XIV,XIX, 1962-67916PRN Radio Guide, vol. 8, no. 2, 1981 Jul-Sep917Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [NIH Publication No. 93-3095], 1993 Sep918Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [NIH Publication No. 98-4080], 1997 Nov Series 4: Subject Files, 1931-2000121 Indexes: Keysort classifications, [ca. 1990-95] Hypertension [H], 1939-96 Saluretic Agents [H-1], 1953-91122-3 Chlorothiazide - Mechanism of action [34.1], 1957-89124 Thiazide - Effects on LVH [34.2], 1982-87125 Thiazide drugs [32], 1958-69, 1984126 Mercurials [31], [after 1985]127 Thiazides' effect on calcium [30], 1990-91128 Aldosterone antagonists [29], 1953-80129 Polythiazide [28], 1961-631210 Non saluretic thiazides [27], 1961-681211 Triamterene and MK870 [26], 1961-851212 Furosemide [25], 1964-791213 Ticrynafen [24], 1978-80 Blocking Agents [H-2], 1946-961214 Hexamethonium - Pharmacology [34A], 1950-601215 Hexamethonium - Treatment, Clinical [34B], 1950-561216 Hexamethonium and Hydralazine [34C], 1952-551217 Hexamethonium and Rauwolfia [34D], 19531218 Hexamethonium - Correspondence and reports [34E], 1951-641219 Pentolinium - Pharmacology [33A], 1956-601220 Pentolinium - Clinical [33B], 1953-561221 Pentolinium - with Hydralazine [33C], 19551222 Pentolinium - with Rauwolfia [33D], 1954-551223 Pentolinium - Correspondence and reports [33E], 1954-551224 Chlorisondamine - Pharmacology [32A], 1954-581225 Chlorisondamine - Treatment [32B], 1955-571226 Chlorisondamine - Correspondence and reports [32C], 1954-561227 Mecamylamine [31], 1955-601228 Miscellaneous blocking drugs - Arfonad [30], 1946-611229 Ganglion blocking agents - Trimethidinium methosulfate [30], 1958-621230 Pempidine [30], 19601231-32 Guanethidine [29], 1959-761233 Darenthin (or Bretylium) [28], 1959-621234 Iproniazid and Catron [27], 1959-631235 Pargyline [26], 1961-641236 Ganglion blocking agents - Literature, side effects, toxicity, tolerance [25], 1948-631237 Ganglion blocking agents - General chemical and pharmacological [25], 1947-631238 Ganglion blocking agents - Clinical uses other than in hypertension [25], 1948-561239 Sympatholytic, selective [23], 1960-661240 General [22], 1948-741241 Phentolamine (Regitine) [21], 19651242-43 Adrenergic blockers - Various (includes Labetalol) [19], 1949-851244 Aldomet [18], 1961-881245-47 Beta adrenergic blockers [17], 1966-961248-49 Propranolol [16], 1966-831250 Angiotensin blockers - including Saralasin [15], 1984-951251 Angiotensin blockers - Enalapril 421 or 521 [15A], 1978-901252 Losartan [15B], 1992-95131 Clonidine [14], 1975-85132 Guanabenz [13], 1981-83133 Thiocyanate [12], [after 1970]134 Calcium Channel Block [7], 199513 Etiology and Pathogenesis [H-3], 1948-95135-6 Renin - Renal pressor theory [34], 1959-90137 Kidney in [hypertension] - Pyelonephritis [33], 1959-70138 Unilateral renal vascular disease [32], 1956-87139 Renoprival [31], 1951-651310 Renal, other [30], 1955-861311-12 Salt in hypertension [29], 1955-871313-14 K+ in diet and Na/K+ Ratio. Also, calcium [29A], 1975-881315 Salt sensitivity - Potassium [29B], 1972-951316 Neural [28], 1975-941317 Baroreceptor theories [27], 1948-911318 Sympathetic nerves [26], 1949-831319 Brain and post, pituitary [25], 1958-881320-21 Emotional stress - Neurogenic, other [ 24], 1950-861322 Adrenal cortex [23], 1949-911323 Hormonal, adrenal medulla [22], 1961-881324 Pituitary in [hypertension] [21], 1948-501325 Hormonal, other [20], 1955-821326 Coarctation of aorta [19], 1951-881327 Hypertension and heredity [18], 1953-871328 Environment [17], 1957-771329 Ca, Mg [16], 19851330-31 Other ions than Na+ - Mg++, Ca++, K+, Cl [15], 1961-941332-33 Fluid volumes in [hypertension] [14], 1952-931334-38 Epidemiological studies [13], 1953-911339-40 Epidemiology - Racial differences [13A], 1956-751341 Exaggerated natriuresis in [hypertension] [12], 1949-621342 Toxemia of pregnancy [11], 1964-841343 Cardiogenic [10], 1962-84141 Miscellaneous [9], 1962-87142 History of hypertension [8] [photograph], [ca. 1960-64]143 Reviews, general [7], 1976-80144 Kallikrein and prostaglandins [6], 1968-85145 Fast-twitch muscle fibers in hypertension - lower body compression [5], 1979-84146 Atrial natriuretic factor [4], 1984-90147 Insulin resistance diabetes [3], 1986-91148 Obesity [3 - crossed out in index], 1987149 Endothelium relaxing factor, etc. [2], 1989 Other Antihypertensive Agents, General Treatment Control Studies [H-4], 1940-961410 Hydralazine - Literature - Clinical [34], 1951-831411 Hydralazine - Literature - Pharmacology [34], 1951-811412 Hydralazine - Literature - Toxicity [34], 1953-821413 Hydralazine - like agents [33], 1945-491414 Rauwolfia - Side effects [32], 1954-831415 Rauwolfia - Crude root [31], 1955-631416 Reserpine - Pharmacology [29], 1954-771417 Reserpine - Antiarrhythmic activity [29], 1955-661418-19 Rauwolfia - Reserpine - Treatment [29], 1954-841420 Rauwolfia - Various alkaloids [28], 1955-651421 Veratrum - Pharmacology [27], 1949-66, 19831422 Veratrum - Viride - Clinical treatment [26], 1948-541423 Control studies [25], 1960-79, 19961424 Veratrum - Other alkaloids - Protoveratrine, etc., Viscum album [24], 1949-591425 Veratrum - Neogermitrine assay data [24], 19501426 Sympathectomy [21], 1940-611427 Miscellaneous [20], 1948-691428 Azide Sodium - Literature [20], 1954-611429 Hypertensive agent IN-66 (Irwin, Neisler and Co.) [20] [Restricted], 1952-19531430 Adrenalectomy [19], 1951-541431-34 Treatment Dietary [18], 1948-57, 1973-911435 Surgery of renal hypertension [17], 19631436 Renal transplants [16], 1964-651437 Diazoxide [15], 19761438 General discussion and review [14], 1974-811439-40 Prazosin [13], 1974-951441 Minoxidil [12], 1973-811442 Cost of drugs [11], 1978-831443-46 FDA and drug regulations [10], 1971-83151 Psychophysiological techniques [9], 1972-84152 National programs [8], 1977-82153 Calcium antagonists - General [7A], 1977-92154 Calcium antagonists - Nitrendipine [7C], [1984-85]155 Calcium antagonists - Diltiazem [7D], 1982-89156 Verapramil [7E], 1982-87157 Exercise [6], 1978-86158 Reverse titration [5], 1967-82159 Serotonin antagonists [4], 1984-86 Clinical [H-5], 1943-931510 General discussion of disease - Reviews [34], 1946-50, 19701511 Subarachnoid hemorrhage [33], 19821512 Left Ventricular Hypertrophy / ECG or VCG in Hypertension [32], 1962-971513 Prognosis, untreated [31], 1943-741514 Treatment effect on prognosis - Indications for Rx mild [30], 1956-881515 Prognosis with surgical [29], 1950-621516 Reactivity in borderline hypertension [28], 1955-901517 Practical details of drug treatment, home BPs, cost, etc. [27], 1974-881518 Antihypertensive Drugs - Treatment, general [26], 1959-931519 Systolic hypertension [25], 1982-881520 Effects of Rx on organic damage (Cardiac, renal) [24] [photograph], 1951-911521-22 Blood pressure recording [23], 1954-901523 Blood pressure - Casual versus basal [22], 1953-891524 Ambulatory BP monitoring [22A], 1981-901525 Miscellaneous symptoms (Headache, etc.) [21], 1962, 1986-881526 Uric acid, gout, gouty nephritis [20], 1963, 19661527 Hypertensive encephalopathy and crisis [19], 1975-921528 Dissecting aneurysm [18], 1968-821529-30 Clinics for hypertension - Detection, costs [17], 1972-981531 Hypertension in children [16], 1960-881532 Physician education - Tests, nurse education, etc. [15], 1959-791533 Hypertension in the aged [14], 1970-921534-35 Obesity - Weight reduction [13], 1967-921536 Comments on trials [12A], 1974-901537-38 Compliance [11], 1967-871539 Blacks and other race [10], 1976-891540 Low lipid diets [9], 1981-871541 Mental and behavioral [with and without] Rx [8], 1971-891542 Stepdown of Rx [7], 1956, 1975-891543 Left Ventricular Hypertrophy [6], 1979-941544 The J curve [5], 1985-911545 Circadian rhythm [4], 19921546 Kidney in hypertension [3], 1988-921547 Diabetes and HBP - Nephropathy [2], 1989-93 Atherosclerosis [H-6], 1949-931548 Atherosclerosis - Cholesterol in [34], 1957-891549 Atherosclerosis and L[ow]-D[ensity] L[ipoproteins] [33], 19821550 Atherosclerosis and dietary fat [32], 1955-901551 Physical activity [31], 1960, 1981-871552 Coronary [30], 1963-82161 Lipids other than cholesterol [29], 1949-59, 1982162 MER 29 - Cholesterol synthesis antagonists [28], 1960-62163 Thyroid substances [27], 1949-57164 Vessel wall factors [26], 1958-93165-6 Miscellaneous drug treatment [25], 1957-91167 Reviews [24], 1976-89168-10 Epidemiology of coronary artery disease [23] [photographs], [1967]-881611 By-pass surgery [22], 1977-901612 Apolipoproteins [21], 19861613 Blood clotting factors and prevention of M[yocardial] I[nfarction] [21], 1980-821614 H[igh]-D[ensity] L[ipoprotein] [20], 1980-911615 C[oronary] H[eart] D[isease] mortality - secondary prevention trials [19], 19841616 Exercise [18], 1982-841617 Acute Miyocardial] I[nfarction] [17], 1988-911618 Hypertension and accelerated atherosclerosis [16] [photograph], 1960-821619 Primary prevention control trials [15], 1984-911620 Treatment of coronary occlusion with anticoagulants [14], 1985-901621 Angina [13], 19841622 Smoking [11], 1991 Organ Systems In and Types of Hypertension [H-7], 1939-891623 Malignant - Untreated [34], 1939, 1948-791624 Malignant - Treated [33] [photographs], 1953-671625 General [32], 19611626 Kidney in [31], 1941-781627 Heart in [30], 1958-891628-29 Brain in [29], 1945-881630 Large vessels in [28], 1955-881631-32 Small vessels in [27], 1956-891633 Other organs in [26], 1952-601634-35 Pheochromocytoma [25], 1954-851636 Fundi [24], 1962, 1980-851637 Adrenal cortex in [23], 1941-751638 Atherosclerosis in [22], 1959-871639 Classification [21], 1946-581640 S[pontaneously] H[ypertensive] R[at] [20], 1956-811641 Veins - Venous tone [19], 1978-871642 Vascular endothelium [18], [ca. 1980-89] Hemodynamics [T], 1941-91 Heart [T-1], 1948-911643 Theoretical concepts - New method [34.1], 19631644-45 Output [33], 1948-63, 1977-841646 Flow [32], 1949-621647 Pressure [31], 1948-641648 Velocity [30], 1962, 19801649 Volume [29], 1955-64, 19911650 Resistance [27], 1963, 19791651 Work [26], 19631652 O2 Consumption [24], 19651653 Metabolism plus pH plus myogenic response [23], 19621654 Electrical phenomena [21], 19591655 Methods - Clearance or Fick [20], 19531656 Methods - Radioisotopic tracers [18], 19801657 Methods - Volume dilution [17], 1954-631658 Methods - Electrocardiography [16], 19591659 Methods - Colorimetric [14], 19611660 Blood oxygen and CO2 [13], 19631661 Elasticity of vessels [12], 1955-621662 Pulse wave contours [10], 1961-621663 Methods - Miscellaneous [8], 1961 Small Vessels [T-2], 1941-87171 Flow [32], 1955-87172 Pressure [31], 1941, 1956173 Volume [29], 1960-64174 Resistance [27], 1960-65175 Anatomical studies [22], 1957176 Methods - Plethysmographic, or other physical [19], 1959-62177 Methods - Radioisotopic tracers [18], 1963178 Nervous control [13], 1963-68179 Electrolytes in relation to [small vessels] [11], 1960 Brain [T-3], 1960-611710 Flow [32], 1960-61 Kidney [T-4], 1951-821711 Flow [32], 1951-821712 Volume [29], 1956-581713 Temperature [28], 19621714 Methods - Radioisotopic tracers [18], 1956-60 Splanchnic Minus Renal [T-5], 1949-631715 Flow [32], 1949-631716 Pressure [31], 1959-631717 Resistance [27], 1962 Coronary Vessels [T-6], 1959-651718 Flow [32], 1964-651719 Methods - Radioisotopic disease [18], 1961-641720 Methods - X-Ray [15], 1959-62 Venous System [T-7], 1952-641721 Flow [32], 19591722 Pressure [31], 1952-551723 Volume [29], 1955-641724 Resistance [27], 19621725 Methods - Plethysmographic, or other physical [19], 1957 Extremity - Total Limb or 9 plus 10 [T-8], 19591726 Methods - Plethysmographic, or other physical [19], 1959 Extremity - Skin or Digit [T-9], 1960-741727 Theoretical concepts [34], 19681728 Flow [32], 1962-641729 Methods - Plethysmographic, or other physical [19], 19601730 Electrolytes in Relation To [11], 1974 Extremity - Muscle or Limb Segment [T-10], 1958-891731 Flow [32], 1958-59, 1988-89 Multiple Organs [T-11], 1952-631732 Flow [32], 1961-631733 Volume [29], 1952, 1961 Aorta and/or Large Arteries [T-13], 1957-731734 Flow [32], 1959-691735 Pressure [31], 1959-731736 Volume [30], 1962-641737 Anatomical studies [22], 19571738 Methods - Clearance or Fick [20], 19621739 Methods - Volume dilution [17], 19651740 Methods - X-Ray [15], 19611741 Elasticity of vessels [12], 1960-621742 Electrolytes in relation to [aorta and/or large arteries] [11], 19601743 Methods - Miscellaneous [8], 1960-61 Pulmonary Circulation [T-14], 1949-651744 Flow [32], 1954-621745 Pressure [31], 1949-631746 Volume [29], 1960-651747 Resistance [27], 19571748 Elasticity of vessels [12], 1962 Lymphatics [T-15], 19591749 Pressure [31], 1959 Miscellaneous [U], 1931-2000 Drugs Other than Antihypertensive Agents [U-1], 1942-861750 Pressor drugs - Epinephrine (Adrenaline) [29], 1957-621751 Pressor drugs - Levarterenol (Norepinephrine) [28], 1953-681752 Pressor drugs - Other sympathomimetic amines [27], 1954-751753 Pressor drugs - Angiotensin [26], 1942, 1957-761754 Pressor drugs - Derived from biological materials [24], 19601755 Cardiac drugs - Digitalis [22], 1948-601756 Cardiac drugs - Quinidine, Pronestyl [21], 1951-601757 Serotonin [14], 1952-591758 Histamine [13], 19691759 Depressor polypeptides (Bradykinin, etc.) [12], 1962-631760 SI Units [11], 1986 Studies Other than Hemodynamics [U-2], 1952-731761 Electrocardiograms [29], 19591762 X-Ray [28], 19611763 Extracellular fluid volume [26], 1952-631764 Total body water [25], 19611765 Total exchangeable sodium or potassium [23], 1955-611766 Total blood volume [22], 1955-681767 Muscle contraction, metabolism, cardiac contraction [21], 1962-631768 Heart sounds and murmurs [20], 19551769 Myogenic response [19], 1959-641770 Electrokymography [18], 19621771 Systolic time intervals [17], 1973 Neural Control of Circulation [U-3], 1959-821772 Catecholamine metabolism [15], 1963-821773 Pineal, including carbolines [14], 19621774 Reflexes with afferents from heart and lung [13], 1959-751775 Sympathetic vasodilator nerves [10], 19611776 Sympathetic vasoconstrictor nerves [9], 1959-601777 General or integrated [8], 1960-631778 Baroreceptors [5], 1961-63, 19781779 Hypothalamus [1], 1959-61 Hemodynamic Techniques [U-4], 1949-871780 Blood Flow - Sonic [29], 19621781 Blood Flow - Thermistor [28], 1949-711782 Blood Flow - Electromagnetic [27], 1952-661783 Blood Flow - Radiopotassium technique and similar [26], 1961-681784 Blood Flow - Other special [25], 1950-611785 Cardiac diameter mercury strain gauge [24], 19531786 Cardiac "force" strain gauge [22], 1950-571787 Blood viscosity [20], 1960-611788 Electrical conductivity [19], 1959-611789 Aortic or other large artery diameter - Methods other than x-ray [18], 19611790 Limb Plethysmography - Strain gauge [17], 1964, 1980-841791 Cardiac output by aortic pulse contour or differential pressure [16], 1949-651792 Cardiac output by dye method [15], 1957-65, 19871793 Blood pressure - Methods for measurement in man [14], 1959-861794 Blood pressure - Methods for measurement in animals [13], 1957-661795 Heart pumps [12], 1960-621796 Renograms [11], 1963-711797 Pulse wave velocity and contour [10], 19641798 Microjuncture techniques [9], 19661799 General animal technique (such as anesthesia, etc.) [8], 196317100 Special animal techniques - Miscellaneous [7], 196317101 Chronic implantation and catheterization technique [6], 196317102 Echocardiography [5], 1971-74 Environmental Factors [U-5], 1955-7517103 Cold [28], 1955-6217104 Exercise [24], 197517105 Hemodynamics - Postural hypotension [22], 1959-6217106 Dissecting aneurysm [11], 1966 Effects of Changes Imposed on the Organism [U-6], 1940-8117107 Exercise [29], 1954-5917108 Posture and postural hypertension [22], 1940-8117109 Smoking [21], 195917110 Fever [20], 195917111 Diving [19], 196217112 Experimental ventricular pre-excitation [18], 1964 Diseases States [U-7], 1945-8317113-114 Cardiac failure [29], 1951-8317115 Myocardial infarction [28], 1954-7617116 Valvular heart disease [27], 1955-5917117 Congenital heart disease [26], 1955-6417118 Other heart disease [25], 195517119 Pulmonary embolism and infarction [24], 196517120 Peripheral vascular diseases - Arterial [22], 1955-6217121 Peripheral vascular diseases - Venous [21], 1955181 Shock [19], 1945-64182 Nephritis, glomerulo and pyelo [17], 1959183 Other renal disorders [16], [1962]184 Cerebrovascular disorders [14], [1963]185 Arteriovenous fistula [12], 1960-62186 Cardiac resuscitation [11], 1962-6418 Computers and General [U-8], 1953-83187 Use as methodology aid [25], 1962188 Diagnostic aid - general [24], 1962189 Diagnostic aid - ECG [23], 1959-61, 19831810 Hydrodynamics, hydraulics [14], 1953-5818 Transmembrane Exchange [U-9], 1955-851811 Transcapillary exchange - Large molecules [29], 1960-63, 1984-851812 Transcapillary exchange - Na[+ ]and K[+] [27], 1957-611813 Transcapillary exchange - Water [26], 19621814 Cellular membrane exchange - Na[+] and K[+] [24], 1955-621815 Cellular membrane exchange - Water [23], 19591816 Cellular membrane exchange - Other molecules [22], 196218 Cooperative Studies and Medical Statistics [U-10], 1960-851817 Methodology of cooperative studies [29], 1961-851818-19 Double blind control studies in hypertension [28], 1960-771820 Medical statistics - General [27], 1961-821821 Medical research [26], 1964-761822 Use of animals in research [25], [after 1952]1823 Medical ethics [24], 196618 [Subjects Not Filed by Freis], 1931-20001824 [Antihypertensive agents], 1947-56, 1977-921825 [Antihypertensive therapy and side effects], 1950, 1973-951826 Apex cardiogram etc., 1959-731827 Arterial distensibility in normotensive and hypertensive patients, 1962-76, 19841828 Arterial elasticity, 1959-65, 1978-871829-30 Arterial pulse contours - literature, 1931, 1956-68212 Arterial pulse contours - literature, 19651831 Arterial wall characteristics [photographs], 1954-711832 Arteriosonde for assessing "basal" BP, 1956, 1976-771833 [Blood flow], 1949, 19761834 Cards, 1968-70213-4 Chronic Bright's Disease, 19741835 Circadian rhythm study, 1988-891836 [Congestive heart failure], 1953-911837 Conjunctival blood vessels, 1983-861838-39 Diuretic hypokalemia, 1963-941840 Ejection period [photograph], 1964-771841 Fixed dose combinations Rx, 19981842 Heart sounds, 1958-721843 [Hexamethonium], 1950-511844 [High blood pressure], 1959-871845 Isovolumic contraction time, 1959-761846 [Kidneys], 1955-581847 KCG [Kinetocardiogram] [photograph], 1959-761848-49 [Leukocytes], 1959-841850 New projects, 1950, 1979-891851 PRA response to HCTZ and BP responsiveness correlation, 1983-901852 [Propranolol], 1969-731853-54 Pulse wave studies, 1955-891855-56 Pulse wave velocity, 1945, 1960-71, 1989-20001857 Rabbit Athero, 1955-641858 Salt volume and prevention of hypertension, 1953-54, 1976-93191 Sodium in WBC in hypertension and after antihypertensive drugs, 1959-76192 Step down, 1975-89193-5 Thiazides - Hypokalemia, 1962-93196 Thiazides - Other side effects, 1991197 Thoughts - Ideas, 1959-60, 1976-82198 Transcapillary exchange in hypertension, 1963-80 Series 5: Studies, ca. 1960-94199 The Effects of Change in Blood Pressure on Various Hemodynamic Events [photographs], ca. 19601910-12 Arterial Pressure and the Effects of Depressor and Pressor Agents [photographs], 1961-621913 Systolic Time Intervals, 19701914-15 Effect of Length of Blood Pressure Cuff on Indirect Measurement of Blood Pressure [photographs], 19711916 ECG Cooperative Study, 19721917 Salt Handling by the Hypertensive Kidney, 19771918 Lability of Blood Pressure in the Aged: Its Association with Baroreceptor Activity and Arterial Wall Stiffness, 1983-851919 Veterans Administration Cooperative Study: Double-Blind Randomized Study to Evaluate the effects of Long-Term Antihypertensive Therapy on Plasma Lipids in Patients with Elevated Cholesterol Levels, 19891920 Trandolapril and Trandolapril/Verapamil - Investigator's brochure, 19901921-24 Veterans Administrations Cooperative Study #290: Monotherapy of Hypertension [Final draft volumes 1-3], 19911925 Veterans Administrations Cooperative Study #290: Monotherapy of Hypertension [typescript], 19921926 Accupril (Quinapril Hydrochloride, CI-906) - Investigator's brochure, 19911927 Accupril - Formulary Data, 19911928 ALLHAT Cooperative Study, 19931929 Biobehavioral Triggers of Myocardial Ischemia, 1994 Series 6: Photographs and Slides, 1972-8520 Personal Photographs, 1972-85201 Portraits of Dr. Freis [negatives only]202 Portraits of Dr. Freis203 Freis at unknown golf tournament, [ca. 1965]204 Portraits of Dr. Freis [negatives only], 1972205 Portrait of Dr. Freis [with negative], 1973206-9 Photograph album - Trip to Moscow and Israel, 1977-852010 Richard Freis and family, 198320 Professional, ca.1950-812011 [Veterans Administration staff], ca. 1950-622012 Freis receiving awards, [1980]-822013 Freis at 4th Scientific Meeting, International Society of Hypertension, 1981 Illustrative Material for Publications and Lectures, 1969-892014-15 Photographs used in journal articles, 1956-782016 Slides on hypertension, antihypertensive therapy, etc.2017-18 Scrapbook of slides for lectures and publications, 1969-89215Slide Atlas of Hypertension, 1980

    Collection Scope and Content Note

    Journal articles and reprints, books, subject files, research data, photographs, slides, and videotapes (1926-2004; 18.3 linear feet) chronicle the work of Edward D. Freis as a pioneer in the research of hypertension and hemodynamics. As a senior medical investigator at the Hypertension Research Clinic, Veterans Affairs Medical Center, Freis conducted many clinical trials that led to the development of more effective treatments for hypertension. However, the collection lacks much of the original clinical data collected during his research; if this data survives they would most likely remain at the V.A. Medical Center.

    His clinical research and overall expertise on hypertension are best represented in Series 3: Writings and Lectures and Series 5: Studies. Freis wrote nearly 400 articles on all aspects of hypertension; the majority of the materials in Series 3 are reprints of articles written by Freis and his colleagues. Several typescripts of his articles are also contained within this series, as are several books on hypertension authored by Freis. Series 5 contains some materials regarding studies with which Freis was involved; these items include "investigator's brochures" (compiled data), study proposals, a final draft from the landmark V.A. Cooperative Study on Antihypertensive Agents, and some illustrative materials such as graphs and photographs.

    In addition to his own reprints, Freis gathered reprints and photocopies of articles and essays by others, which he annotated and supplemented with his own notes, research data, and other materials (Series 4: Subject Files). Freis organized these files into three main subject areas: Hypertension, Hemodynamics, and Miscellaneous; he also created a detailed index to the scheme. Each main subject was given a unique letter designation: H for hypertension, T for hemodynamics, and U for Miscellaneous. Subsets within each main category were numbered in ascending order, while the individual component folders were numbered in descending order (usually beginning with 34). These numbers are found within square brackets. The index contains missing file numbers, presumably by intent and to be filled in later. During processing, unclassified files were arranged alphabetically in the subseries Subjects Not Filed by Freis; when missing, titles were supplied and marked by square brackets.

    Also included in the Writings and Lectures series are audio recordings, videotapes, and transcripts of medical lectures and interviews given by Freis throughout his career to various audiences. Many of the videotapes were dubbed in the late 1980s from the original films, whose locations are unknown. One videotape, "Early Hypertension TV Broadcasts," contains lectures for the American College of Physicians (1954) and the CIBA TV Clinical Symposium (1959) whereby the audience watched the speaker through closed circuit television, making them a novel presentation method for that period in time.

    The collection contains little personal information about Freis apart from the scrapbooks that comprise Series 2. The scrapbooks themselves contain article reprints, some photographs, some correspondence, and programs from conferences, symposia, award ceremonies, etc. at which Freis participated or attended and are arranged chronologically. While most of the scrapbooks profile Freis's career, the next to last album in the series pertains to his retirement from the Veterans Administration; the contents consist of letters of congratulations from friends and colleagues (including Walter Mondale), as well as photographs from the farewell dinner.

    In addition to the scrapbook materials, Series 1: Personal and Biographical includes CVs and bibliographies from various points in Freis's career, including a recent one from 2001. A few items document the numerous awards received by Freis, although some of the actual awards are contained within this series. Also of interest are several of Freis's golf diaries that range in date from the 1970s until just a few years before his death. A handful of portrait photographs of Freis are included among the photographic materials in Series 6, however the bulk of the series contains illustrations for lectures and articles. The slides appear to have been used by Freis during lectures and for some of his publications. He mixed and matched slides to create different lectures and others were pulled to be used in publications; they are arranged loosely by topic when possible.

    Contents List
    Box | Folder Title
     
    Series 1: Personal and Biographical, 1969-2002 [series]:
     
    Resumes, CVs, Bibliographies, 1974-2001 [subseries]:
    1 1
    Who's Who biographical data form, 1974
    1 2
    CV, ca. 1979
    1 3
    CV and bibliography, 1998-2001
    1 4
    CV, 2002
     
    Awards, 1992-2002 [subseries]:
    1 5
    Lasker Award [program, clippings, etc.], 1971
    1 6
    Howard Blakeslee Award, [1980]
    1 7
    Nobel Peace Prize nomination [correspondence], 1992
    1 8
    Stevo Julius Award, 2000
    1 9
    American Heart Association Award of Achievement [correspondence], 2001
    22 2
    Plaque of appreciation, Veterans Administration Study, [ca. 1970]
    22 3
    Oscar B. Hunter Award, American Society for Clinical Pharmacology and Therapeutics [plaque], 1972
    22 4
    Medical Science Achievement Award, American Heart Association [plaque], 1984
    1 10
    Department of Veterans Affairs Exemplary Service Award, 2002
     
    Medical Licenses and Memberships, 1940-51 [subseries]:
    1 11
    New York Academy of Sciences membership certificate, 1951
    22 1
    Massachusetts state medical license, 1948
    22 1
    Massachusetts Medical Society membership certificate, 1949
    21 10
    New York state medical license, 1940
    1 12-15
    Golf Diaries, 1977-98
    1 16
    Correspondence, Professional Organizations, 1997-2000
    1 17
    Correspondence, Personal, 1981
    21 9
    Pencil drawing of Freis, 1977
    2 vols.
    Grand Rounds, Georgetown University School of Medicine [2 volumes], 1969, 1982
     
    Presentation volumes [subseries]:
    2 vol.
    Freis. The High Blood Pressure Book, 1979
    3 vol.
    Angiology, The Journal of Vascular Diseases, vol. 11 [award copy], 1960
    3 vol.
    Stapleton, John F. Upward Journey: the Story of Internal Medicine at Georgetown, 1851-1981, 1996
    3 vol.
    Page, Irvine H. Hypertension Research: a Memoir 1920-1960, 1988
    3 vol.
    Hypertension Update: Mechanisms, Epidemiology, Evaluation, Management, 1980
     
    Series 2: Scrapbooks, 1926-2004 [series]:
    4 1
    Scrapbook 1, 1926-61
    4 2-3
    Scrapbook 2 [photographs], 1942-53
    4 4-8
    Scrapbook 3, 1942-59
    4 9-10
    Scrapbook 4, 1952-58
    4 11-12
    Scrapbook 5, 1953-57
    4 13-14
    Scrapbook 6, 1954-59
    4 15-17
    Scrapbook 7 [photograph], 1959-61
    4 18-19
    Scrapbook 8 [photograph], 1959-61
    4 20-21
    Scrapbook 9, 1960-61
    4 22-25
    Scrapbook 10 [photographs], 1961-72
    4 26-28
    Scrapbook 11 [photographs], 1962-65
    4 29-31
    Scrapbook 12 [photographs], 1965-72
    4 32-33
    Scrapbook 13 [photographs], 1966
    5 1-2
    Scrapbook 14 [photographs], 1967-68
    5 3-5
    Scrapbook 15 [photographs], 1967-70
    5 6-8
    Scrapbook 16 [photographs], 1969-1971
    5 9-11
    Scrapbook 17 [photographs], 1970-74
    5 12-14
    Scrapbook 18 [photographs], 1970-74
    5 15-17
    Scrapbook 19 [photographs], 1970-79
    5 18-21
    Scrapbook 20 [photographs], 1971-72
    5 22-23
    Scrapbook 21 [photographs], 1971-76
    5 24-25
    Scrapbook 22 [photographs], 1972
    5 26-29
    Scrapbook 23 [photographs], 1973
    5 30-31
    Scrapbook 24 [photographs], 1974
    5 32-34
    Scrapbook 25 [photographs], 1974
    6 1-3
    Scrapbook 26 [photographs], 1975-76
    6 4
    Scrapbook 27 [photographs], 1975-76
    6 5-6
    Scrapbook 28 [photographs], 1976-77
    6 7-8
    Scrapbook 29 [photographs], 1976-77
    6 9-10
    Scrapbook 30 [photographs], 1978-79
    6 11-13
    Scrapbook 31 [photographs], 1978-81
    6 14-15
    Scrapbook 32 [photographs], 1979-80
    6 16-18
    Scrapbook 33 [photographs], 1980-85
    6 19-20
    Scrapbook 34 [photographs], 1980-85
    6 21-22
    Scrapbook 35 [photographs], 1981-82
    6 23-24
    Scrapbook 36, 1982
    6 25-26
    Scrapbook 37, 1982-83
    6 27-28
    Scrapbook 38, 1982-88
    6 29-38
    Scrapbook 39 - Freis' retirement [photographs], 1986-87
    6 39-40
    Scrapbook 40 [photographs], 1990-2004
     
    Series 3: Writings, Lectures and Public Appearances, 1942-2002 [series]:
     
    Correspondence, 1993-2000 [subseries]:
    7 1
    Adis International, 1993-97
    7 2
    Archives of Internal Medicine, 1999
    7 3
    Comprehensive Therapy, 2000
    7 4
    Hypertension and Le Jacq Communications, 1997
    7 5
    Perry, Mitch, 2000
    7 6
    Abstracts, 1975-86
     
    Freis reprints, 1942-2001 [subseries]:
    7 7
    A - Al, 1949-92
    7 8
    An - As, 1950-86
    7 9
    B, 1949-86
    7 10
    Ca - Ch, 1958-86
    7 11
    Cl, 1942-77
    7 12
    Col - Com, 1943-86
    7 13
    Con - Cu, 1957-89
    7 14
    D, 1954-85
    7 15
    Ea - Effect (S), 1947-85
    7 16
    Effect (T) - Effects (R), 1953-1989
    7 17
    Effects (S - V), 1955-1974
    7 18
    Effi - Es, 1944-1983
    7 19
    Ev - Ex, 1950-1972
    7 20
    F - G, 1960-79
    7 21
    Ha - Hemodynamic (C), 1951-79
    7 22
    Hemodynamic (E - T), 1949-82
    7 23
    Hemodynamics - Hypertension (A), 1960-95
    7 24
    Hypertension (C - Q), 1956-77
    7 25
    Hypertension (R) - Hypertensive, 1962-93
    7 26
    I - L, 1944-86
    7 27
    Ma - Med (E), 1955-78
    7 28
    Med (R) - Mu, 1949-84
    7 29
    Na, 1972
    7 30
    Ne - No, 1974-83
    7 31
    O, 1949-93
    7 32
    Pa - Pra, 1948-89
    7 33
    Pre, 1960-84
    7 34
    Pri - Pro, 1970-94
    7 35
    Ra - Rec, 1948-90
    7 36
    Rel - Res, 1944-95
    7 37
    Ret - Ro, 1960-92
    7 38
    Sa - Si, 1947-93
    7 39
    So - Sy, 1949-2001
    7 40
    Th - Tre (E), 1953-88
    7 41
    Tre (H - L), 1952-91
    7 42
    Tre (M) - Tri, 1944-82
    8 1
    U - Va, 1952-92
    8 2
    Ve - W, 1951-2001
     
    Typescripts and Proofs, 1963-2000 [subseries]:
    8 3
    "Combined L-Alpha Methyl DOPA and Sulfonamide Diuretic Therapy of Hypertension" [photographs], 1963
    8 4
    "Current Drug Treatment for Hypertension", 1999
    8 5
    "Current Status of Diuretics, Beta-Blockers, Alpha-Blockers, and Alpha-Beta-Blockers in the Treatment of Hypertension", 1996
    8 6
    "Diuretics and the Latest JNC Report", 1995
    8 7
    "Dose Response Curve for Hydrochlorothiazide in Essential Hypertension", 1989
    8 8
    "Double-Blind Assessment of Tienilic Acid in Essential Hypertension" [photographs], [1979]
    8 9
    "Drug Lag" [Letter to the editor of JAMA], 1975
    8 10
    "Fixed-Dose Two-Drug Combinations for the Treatment of Hypertension", 2000
    8 11
    "Improving Treatment Effectiveness in Hypertension", 2001
    8 12
    "Increased Mortality Among Young Black Hypertensive Veterans from the 'Stroke Belt'", ca. 1990
    8 13
    "Influence of the Adrenergic System in Renovascular Hypertension" [photographs], [1971]
    8 14
    "Influence of the Sino-Aortic Reflexes on the Control of Arterial pH, Po2, and Pco2 during Wakefulness and Sleep" [photographs], 1969
    8 15
    "Making Antihypertensive Drug Treatment More Effective", ca. 1999
    8 16
    "Mechanism of Antihypertensive Effect of Thiazide Diuretics", [1978]
    8 17
    "Methodology of Multiclinic Therapeutic Trials in Hypertension", [1967]
    8 18
    "Prognosis in Elderly Hypertensive Patients", 1993-94
    8 19
    "Role of Left Ventricular Hypertrophy in Essential Hypertension", [ca. 1980]
    8 20
    "The Role of Salt in Hypertension", 1992
    8 21
    "Sodium Deprivation as an Approach to Hypertension", [1981]
    8 22
    "The Treatment of Hypertension: Why, When, and How", [1972]
    8 23
    "Venomotor Control and Cardiac Preload", 1993
    8 24
    "The Veterans Administration Therapeutic Trial in Hypertension", [ca. 1973]
    8 25
    "The Veterans Administration Trial" [photographs], 1998-99
     
    Lectures, Interviews, Testimonies, Appearances, 1954-98 [subseries]:
     
    Transcripts [subseries]:
    9 1
    "Development of the Salt-Volume Concept in Hypertension" [transcript and slides], ca. 1975
    9 2
    "Hydraulics of Hypertension: New Insights for Patient Management" [lecture outline with slides], 1979
    9 3
    Oral history interview with Dr. Freis conducted by Dr. Marvin Moser [transcript], 1998
    9 4
    Testimony of panel of medical investigators, National Academy of Sciences Study of Health Care for American Veterans and the VA Response, 1978
     
    Audio Recordings [subseries]:
    10
    "Clinical Practice of Cardiology: Modern Pharmacological Management of Systemic Hypertension" [audio cassette with slides]
    10
    "Drs. Fries [sic] and Smith: Hypertension" [audio cassette]
    10
    Internal Medicine vol. 7 no. 2: "Symposium on the Hypertensive State" [magnetic tape reel], 1960 Jan 18
    10
    Internal Medicine vol. 7 no. 3: "Symposium on the Hypertensive State, Part II" [magnetic tape reel], 1960 Feb 1
    10
    Internal Medicine vol. 8 no. 24: "Atherosclerosis and Hypertension: Renal Vascular Hypertension" [magnetic tape reel], 1961 Dec 25
    10
    News Conference on Results of Coop. Study [magnetic tape reel], 1970 Aug 17
    10
    "Today's Therapeutics with Walter Modell: Hypertension" [audio cassette], 1972
    10
    "New Directions in Hypertension, vol. 1: Grand Rounds" [audio cassette], 1973
    10
    "Hypertension Reporter, vol. 2: Practical Problems in the Office Management of Hypertension" [audio cassette], 1974
    10
    "Hypertension Hotline, Houston Texas" [audio cassette], 1974 May 14-15
    10
    "Hypertension Reporter #12, Sides A & B, Synthesis Communications / Freis and Materson" [audio cassette], 1978
    10
    "[Dr. Freis's] talk in Miami", 1980 Mar 13
    10
    "Dr. Fries [sic] and Dr. Moser interview on hypertension" [audio cassette], 1996 Apr 8
    10
    "personal journeys: conversations with people of special dedication" [audio cassette], [1997]
     
    Video recordings [subseries]:
    11
    "Early Hypertension TV Broadcasts": American College of Physicians; CIBA TV Clinical Symposium [VHS tape], 1954, 1959
    11
    "Medcom Lecture: Clinical Management of Hypertension" [VHS tape], ca. 1975
    11
    "Beta-Adrenergic Blockade TV Symposium, Part I" [3/4" tape], 1977 Oct 4
    11
    "War Against Hypertension" [VHS tape], 1987
    11
    "VA Coop. Study Media Coverage / Dr. Edward Freis" [VHS tape], 1993 Apr
     
    Writings about Freis's work, 1952-2002 [subseries]:
    9 5
    Davis, Maxine. "Hypertension," Good Housekeeping, 1952 May
    21 8
    Silverman, Milton. "It knocks down high blood pressure," The Saturday Evening Post, 1952 July 12
    9 6
    de Kruif, Paul. "Rauwolfia Against High Blood Pressure," Reader's Digest, 1954 Aug
    21 1
    Pearse, Ben. "The Pill with the Built-In Surprise," The Saturday Evening Post, 1958 Oct 4
    9 7
    Contemporaries: Edward D. Freis, M.D., Modern Medicine, 1962 Nov
    9 8
    Galton, Lawrence. "High Blood Pressure: New Light on a Hidden Killer," Reader's Digest, 1971 Jun
    9 9
    Stoler, Peter and Jean Bergerud. "Hypertension: Conquering the Silent Killer," Time, 1975 Jan 13
    21 7
    Bloom, Hugh. "Men who changed therapeutics: Dr. Edward D. Freis, proving the value of antihypertensive therapy," Therapies, 1979 May 12
    9 10
    Moore, Thomas J. "How Doctors Oversell the Risks of High Blood Pressure," Washingtonian, 1990 Aug
    9 11
    Moser, Marvin. Myths, Misconceptions, and Heroics: the Story of theTreatment of Hypertension from the 1930's, 1997
    9
    Research works, by others, 1950-2001 [subseries]:
    9 12
    American Journal of Hypertension, vol. 10, no. 7, pt. 2, 1997 Jul
    9 13
    Drugs, vol. 1, suppl. 1, 1976
    9 14
    Emergency Department: Rapid Identification and Treatment of Patients with Acute Myocardial Infarction [NIH Publication No. 93-3278], 1993 Sep
    9 15
    Hypertension: Proceedings of the Council for High Blood Pressure Research, vol. XI, XIV,XIX, 1962-67
    9 16
    PRN Radio Guide, vol. 8, no. 2, 1981 Jul-Sep
    9 17
    Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [NIH Publication No. 93-3095], 1993 Sep
    9 18
    Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [NIH Publication No. 98-4080], 1997 Nov
     
    Series 4: Subject Files, 1931-2000 [series]:
    12 1
    Indexes: Keysort classifications, [ca. 1990-95]
     
    Hypertension [H], 1939-96 [subseries]:
     
    Saluretic Agents [H-1], 1953-91 [subseries]:
    12 2-3
    Chlorothiazide - Mechanism of action [34.1], 1957-89
    12 4
    Thiazide - Effects on LVH [34.2], 1982-87
    12 5
    Thiazide drugs [32], 1958-69, 1984
    12 6
    Mercurials [31], [after 1985]
    12 7
    Thiazides' effect on calcium [30], 1990-91
    12 8
    Aldosterone antagonists [29], 1953-80
    12 9
    Polythiazide [28], 1961-63
    12 10
    Non saluretic thiazides [27], 1961-68
    12 11
    Triamterene and MK870 [26], 1961-85
    12 12
    Furosemide [25], 1964-79
    12 13
    Ticrynafen [24], 1978-80
     
    Blocking Agents [H-2], 1946-96 [subseries]:
    12 14
    Hexamethonium - Pharmacology [34A], 1950-60
    12 15
    Hexamethonium - Treatment, Clinical [34B], 1950-56
    12 16
    Hexamethonium and Hydralazine [34C], 1952-55
    12 17
    Hexamethonium and Rauwolfia [34D], 1953
    12 18
    Hexamethonium - Correspondence and reports [34E], 1951-64
    12 19
    Pentolinium - Pharmacology [33A], 1956-60
    12 20
    Pentolinium - Clinical [33B], 1953-56
    12 21
    Pentolinium - with Hydralazine [33C], 1955
    12 22
    Pentolinium - with Rauwolfia [33D], 1954-55
    12 23
    Pentolinium - Correspondence and reports [33E], 1954-55
    12 24
    Chlorisondamine - Pharmacology [32A], 1954-58
    12 25
    Chlorisondamine - Treatment [32B], 1955-57
    12 26
    Chlorisondamine - Correspondence and reports [32C], 1954-56
    12 27
    Mecamylamine [31], 1955-60
    12 28
    Miscellaneous blocking drugs - Arfonad [30], 1946-61
    12 29
    Ganglion blocking agents - Trimethidinium methosulfate [30], 1958-62
    12 30
    Pempidine [30], 1960
    12 31-32
    Guanethidine [29], 1959-76
    12 33
    Darenthin (or Bretylium) [28], 1959-62
    12 34
    Iproniazid and Catron [27], 1959-63
    12 35
    Pargyline [26], 1961-64
    12 36
    Ganglion blocking agents - Literature, side effects, toxicity, tolerance [25], 1948-63
    12 37
    Ganglion blocking agents - General chemical and pharmacological [25], 1947-63
    12 38
    Ganglion blocking agents - Clinical uses other than in hypertension [25], 1948-56
    12 39
    Sympatholytic, selective [23], 1960-66
    12 40
    General [22], 1948-74
    12 41
    Phentolamine (Regitine) [21], 1965
    12 42-43
    Adrenergic blockers - Various (includes Labetalol) [19], 1949-85
    12 44
    Aldomet [18], 1961-88
    12 45-47
    Beta adrenergic blockers [17], 1966-96
    12 48-49
    Propranolol [16], 1966-83
    12 50
    Angiotensin blockers - including Saralasin [15], 1984-95
    12 51
    Angiotensin blockers - Enalapril 421 or 521 [15A], 1978-90
    12 52
    Losartan [15B], 1992-95
    13 1
    Clonidine [14], 1975-85
    13 2
    Guanabenz [13], 1981-83
    13 3
    Thiocyanate [12], [after 1970]
    13 4
    Calcium Channel Block [7], 1995
    13
    Etiology and Pathogenesis [H-3], 1948-95 [subseries]:
    13 5-6
    Renin - Renal pressor theory [34], 1959-90
    13 7
    Kidney in [hypertension] - Pyelonephritis [33], 1959-70
    13 8
    Unilateral renal vascular disease [32], 1956-87
    13 9
    Renoprival [31], 1951-65
    13 10
    Renal, other [30], 1955-86
    13 11-12
    Salt in hypertension [29], 1955-87
    13 13-14
    K+ in diet and Na/K+ Ratio. Also, calcium [29A], 1975-88
    13 15
    Salt sensitivity - Potassium [29B], 1972-95
    13 16
    Neural [28], 1975-94
    13 17
    Baroreceptor theories [27], 1948-91
    13 18
    Sympathetic nerves [26], 1949-83
    13 19
    Brain and post, pituitary [25], 1958-88
    13 20-21
    Emotional stress - Neurogenic, other [ 24], 1950-86
    13 22
    Adrenal cortex [23], 1949-91
    13 23
    Hormonal, adrenal medulla [22], 1961-88
    13 24
    Pituitary in [hypertension] [21], 1948-50
    13 25
    Hormonal, other [20], 1955-82
    13 26
    Coarctation of aorta [19], 1951-88
    13 27
    Hypertension and heredity [18], 1953-87
    13 28
    Environment [17], 1957-77
    13 29
    Ca, Mg [16], 1985
    13 30-31
    Other ions than Na+ - Mg++, Ca++, K+, Cl [15], 1961-94
    13 32-33
    Fluid volumes in [hypertension] [14], 1952-93
    13 34-38
    Epidemiological studies [13], 1953-91
    13 39-40
    Epidemiology - Racial differences [13A], 1956-75
    13 41
    Exaggerated natriuresis in [hypertension] [12], 1949-62
    13 42
    Toxemia of pregnancy [11], 1964-84
    13 43
    Cardiogenic [10], 1962-84
    14 1
    Miscellaneous [9], 1962-87
    14 2
    History of hypertension [8] [photograph], [ca. 1960-64]
    14 3
    Reviews, general [7], 1976-80
    14 4
    Kallikrein and prostaglandins [6], 1968-85
    14 5
    Fast-twitch muscle fibers in hypertension - lower body compression [5], 1979-84
    14 6
    Atrial natriuretic factor [4], 1984-90
    14 7
    Insulin resistance diabetes [3], 1986-91
    14 8
    Obesity [3 - crossed out in index], 1987
    14 9
    Endothelium relaxing factor, etc. [2], 1989
     
    Other Antihypertensive Agents, General Treatment Control Studies [H-4], 1940-96 [subseries]:
    14 10
    Hydralazine - Literature - Clinical [34], 1951-83
    14 11
    Hydralazine - Literature - Pharmacology [34], 1951-81
    14 12
    Hydralazine - Literature - Toxicity [34], 1953-82
    14 13
    Hydralazine - like agents [33], 1945-49
    14 14
    Rauwolfia - Side effects [32], 1954-83
    14 15
    Rauwolfia - Crude root [31], 1955-63
    14 16
    Reserpine - Pharmacology [29], 1954-77
    14 17
    Reserpine - Antiarrhythmic activity [29], 1955-66
    14 18-19
    Rauwolfia - Reserpine - Treatment [29], 1954-84
    14 20
    Rauwolfia - Various alkaloids [28], 1955-65
    14 21
    Veratrum - Pharmacology [27], 1949-66, 1983
    14 22
    Veratrum - Viride - Clinical treatment [26], 1948-54
    14 23
    Control studies [25], 1960-79, 1996
    14 24
    Veratrum - Other alkaloids - Protoveratrine, etc., Viscum album [24], 1949-59
    14 25
    Veratrum - Neogermitrine assay data [24], 1950
    14 26
    Sympathectomy [21], 1940-61
    14 27
    Miscellaneous [20], 1948-69
    14 28
    Azide Sodium - Literature [20], 1954-61
    14 29
    Hypertensive agent IN-66 (Irwin, Neisler and Co.) [20] [Restricted], 1952-1953
    14 30
    Adrenalectomy [19], 1951-54
    14 31-34
    Treatment Dietary [18], 1948-57, 1973-91
    14 35
    Surgery of renal hypertension [17], 1963
    14 36
    Renal transplants [16], 1964-65
    14 37
    Diazoxide [15], 1976
    14 38
    General discussion and review [14], 1974-81
    14 39-40
    Prazosin [13], 1974-95
    14 41
    Minoxidil [12], 1973-81
    14 42
    Cost of drugs [11], 1978-83
    14 43-46
    FDA and drug regulations [10], 1971-83
    15 1
    Psychophysiological techniques [9], 1972-84
    15 2
    National programs [8], 1977-82
    15 3
    Calcium antagonists - General [7A], 1977-92
    15 4
    Calcium antagonists - Nitrendipine [7C], [1984-85]
    15 5
    Calcium antagonists - Diltiazem [7D], 1982-89
    15 6
    Verapramil [7E], 1982-87
    15 7
    Exercise [6], 1978-86
    15 8
    Reverse titration [5], 1967-82
    15 9
    Serotonin antagonists [4], 1984-86
     
    Clinical [H-5], 1943-93 [subseries]:
    15 10
    General discussion of disease - Reviews [34], 1946-50, 1970
    15 11
    Subarachnoid hemorrhage [33], 1982
    15 12
    Left Ventricular Hypertrophy / ECG or VCG in Hypertension [32], 1962-97
    15 13
    Prognosis, untreated [31], 1943-74
    15 14
    Treatment effect on prognosis - Indications for Rx mild [30], 1956-88
    15 15
    Prognosis with surgical [29], 1950-62
    15 16
    Reactivity in borderline hypertension [28], 1955-90
    15 17
    Practical details of drug treatment, home BPs, cost, etc. [27], 1974-88
    15 18
    Antihypertensive Drugs - Treatment, general [26], 1959-93
    15 19
    Systolic hypertension [25], 1982-88
    15 20
    Effects of Rx on organic damage (Cardiac, renal) [24] [photograph], 1951-91
    15 21-22
    Blood pressure recording [23], 1954-90
    15 23
    Blood pressure - Casual versus basal [22], 1953-89
    15 24
    Ambulatory BP monitoring [22A], 1981-90
    15 25
    Miscellaneous symptoms (Headache, etc.) [21], 1962, 1986-88
    15 26
    Uric acid, gout, gouty nephritis [20], 1963, 1966
    15 27
    Hypertensive encephalopathy and crisis [19], 1975-92
    15 28
    Dissecting aneurysm [18], 1968-82
    15 29-30
    Clinics for hypertension - Detection, costs [17], 1972-98
    15 31
    Hypertension in children [16], 1960-88
    15 32
    Physician education - Tests, nurse education, etc. [15], 1959-79
    15 33
    Hypertension in the aged [14], 1970-92
    15 34-35
    Obesity - Weight reduction [13], 1967-92
    15 36
    Comments on trials [12A], 1974-90
    15 37-38
    Compliance [11], 1967-87
    15 39
    Blacks and other race [10], 1976-89
    15 40
    Low lipid diets [9], 1981-87
    15 41
    Mental and behavioral [with and without] Rx [8], 1971-89
    15 42
    Stepdown of Rx [7], 1956, 1975-89
    15 43
    Left Ventricular Hypertrophy [6], 1979-94
    15 44
    The J curve [5], 1985-91
    15 45
    Circadian rhythm [4], 1992
    15 46
    Kidney in hypertension [3], 1988-92
    15 47
    Diabetes and HBP - Nephropathy [2], 1989-93
     
    Atherosclerosis [H-6], 1949-93 [subseries]:
    15 48
    Atherosclerosis - Cholesterol in [34], 1957-89
    15 49
    Atherosclerosis and L[ow]-D[ensity] L[ipoproteins] [33], 1982
    15 50
    Atherosclerosis and dietary fat [32], 1955-90
    15 51
    Physical activity [31], 1960, 1981-87
    15 52
    Coronary [30], 1963-82
    16 1
    Lipids other than cholesterol [29], 1949-59, 1982
    16 2
    MER 29 - Cholesterol synthesis antagonists [28], 1960-62
    16 3
    Thyroid substances [27], 1949-57
    16 4
    Vessel wall factors [26], 1958-93
    16 5-6
    Miscellaneous drug treatment [25], 1957-91
    16 7
    Reviews [24], 1976-89
    16 8-10
    Epidemiology of coronary artery disease [23] [photographs], [1967]-88
    16 11
    By-pass surgery [22], 1977-90
    16 12
    Apolipoproteins [21], 1986
    16 13
    Blood clotting factors and prevention of M[yocardial] I[nfarction] [21], 1980-82
    16 14
    H[igh]-D[ensity] L[ipoprotein] [20], 1980-91
    16 15
    C[oronary] H[eart] D[isease] mortality - secondary prevention trials [19], 1984
    16 16
    Exercise [18], 1982-84
    16 17
    Acute Miyocardial] I[nfarction] [17], 1988-91
    16 18
    Hypertension and accelerated atherosclerosis [16] [photograph], 1960-82
    16 19
    Primary prevention control trials [15], 1984-91
    16 20
    Treatment of coronary occlusion with anticoagulants [14], 1985-90
    16 21
    Angina [13], 1984
    16 22
    Smoking [11], 1991
     
    Organ Systems In and Types of Hypertension [H-7], 1939-89 [subseries]:
    16 23
    Malignant - Untreated [34], 1939, 1948-79
    16 24
    Malignant - Treated [33] [photographs], 1953-67
    16 25
    General [32], 1961
    16 26
    Kidney in [31], 1941-78
    16 27
    Heart in [30], 1958-89
    16 28-29
    Brain in [29], 1945-88
    16 30
    Large vessels in [28], 1955-88
    16 31-32
    Small vessels in [27], 1956-89
    16 33
    Other organs in [26], 1952-60
    16 34-35
    Pheochromocytoma [25], 1954-85
    16 36
    Fundi [24], 1962, 1980-85
    16 37
    Adrenal cortex in [23], 1941-75
    16 38
    Atherosclerosis in [22], 1959-87
    16 39
    Classification [21], 1946-58
    16 40
    S[pontaneously] H[ypertensive] R[at] [20], 1956-81
    16 41
    Veins - Venous tone [19], 1978-87
    16 42
    Vascular endothelium [18], [ca. 1980-89]
     
    Hemodynamics [T], 1941-91 [subseries]:
     
    Heart [T-1], 1948-91 [subseries]:
    16 43
    Theoretical concepts - New method [34.1], 1963
    16 44-45
    Output [33], 1948-63, 1977-84
    16 46
    Flow [32], 1949-62
    16 47
    Pressure [31], 1948-64
    16 48
    Velocity [30], 1962, 1980
    16 49
    Volume [29], 1955-64, 1991
    16 50
    Resistance [27], 1963, 1979
    16 51
    Work [26], 1963
    16 52
    O2 Consumption [24], 1965
    16 53
    Metabolism plus pH plus myogenic response [23], 1962
    16 54
    Electrical phenomena [21], 1959
    16 55
    Methods - Clearance or Fick [20], 1953
    16 56
    Methods - Radioisotopic tracers [18], 1980
    16 57
    Methods - Volume dilution [17], 1954-63
    16 58
    Methods - Electrocardiography [16], 1959
    16 59
    Methods - Colorimetric [14], 1961
    16 60
    Blood oxygen and CO2 [13], 1963
    16 61
    Elasticity of vessels [12], 1955-62
    16 62
    Pulse wave contours [10], 1961-62
    16 63
    Methods - Miscellaneous [8], 1961
     
    Small Vessels [T-2], 1941-87 [subseries]:
    17 1
    Flow [32], 1955-87
    17 2
    Pressure [31], 1941, 1956
    17 3
    Volume [29], 1960-64
    17 4
    Resistance [27], 1960-65
    17 5
    Anatomical studies [22], 1957
    17 6
    Methods - Plethysmographic, or other physical [19], 1959-62
    17 7
    Methods - Radioisotopic tracers [18], 1963
    17 8
    Nervous control [13], 1963-68
    17 9
    Electrolytes in relation to [small vessels] [11], 1960
     
    Brain [T-3], 1960-61 [subseries]:
    17 10
    Flow [32], 1960-61
     
    Kidney [T-4], 1951-82 [subseries]:
    17 11
    Flow [32], 1951-82
    17 12
    Volume [29], 1956-58
    17 13
    Temperature [28], 1962
    17 14
    Methods - Radioisotopic tracers [18], 1956-60
     
    Splanchnic Minus Renal [T-5], 1949-63 [subseries]:
    17 15
    Flow [32], 1949-63
    17 16
    Pressure [31], 1959-63
    17 17
    Resistance [27], 1962
     
    Coronary Vessels [T-6], 1959-65 [subseries]:
    17 18
    Flow [32], 1964-65
    17 19
    Methods - Radioisotopic disease [18], 1961-64
    17 20
    Methods - X-Ray [15], 1959-62
     
    Venous System [T-7], 1952-64 [subseries]:
    17 21
    Flow [32], 1959
    17 22
    Pressure [31], 1952-55
    17 23
    Volume [29], 1955-64
    17 24
    Resistance [27], 1962
    17 25
    Methods - Plethysmographic, or other physical [19], 1957
     
    Extremity - Total Limb or 9 plus 10 [T-8], 1959 [subseries]:
    17 26
    Methods - Plethysmographic, or other physical [19], 1959
     
    Extremity - Skin or Digit [T-9], 1960-74 [subseries]:
    17 27
    Theoretical concepts [34], 1968
    17 28
    Flow [32], 1962-64
    17 29
    Methods - Plethysmographic, or other physical [19], 1960
    17 30
    Electrolytes in Relation To [11], 1974
     
    Extremity - Muscle or Limb Segment [T-10], 1958-89 [subseries]:
    17 31
    Flow [32], 1958-59, 1988-89
     
    Multiple Organs [T-11], 1952-63 [subseries]:
    17 32
    Flow [32], 1961-63
    17 33
    Volume [29], 1952, 1961
     
    Aorta and/or Large Arteries [T-13], 1957-73 [subseries]:
    17 34
    Flow [32], 1959-69
    17 35
    Pressure [31], 1959-73
    17 36
    Volume [30], 1962-64
    17 37
    Anatomical studies [22], 1957
    17 38
    Methods - Clearance or Fick [20], 1962
    17 39
    Methods - Volume dilution [17], 1965
    17 40
    Methods - X-Ray [15], 1961
    17 41
    Elasticity of vessels [12], 1960-62
    17 42
    Electrolytes in relation to [aorta and/or large arteries] [11], 1960
    17 43
    Methods - Miscellaneous [8], 1960-61
     
    Pulmonary Circulation [T-14], 1949-65 [subseries]:
    17 44
    Flow [32], 1954-62
    17 45
    Pressure [31], 1949-63
    17 46
    Volume [29], 1960-65
    17 47
    Resistance [27], 1957
    17 48
    Elasticity of vessels [12], 1962
     
    Lymphatics [T-15], 1959 [subseries]:
    17 49
    Pressure [31], 1959
     
    Miscellaneous [U], 1931-2000 [subseries]:
     
    Drugs Other than Antihypertensive Agents [U-1], 1942-86 [subseries]:
    17 50
    Pressor drugs - Epinephrine (Adrenaline) [29], 1957-62
    17 51
    Pressor drugs - Levarterenol (Norepinephrine) [28], 1953-68
    17 52
    Pressor drugs - Other sympathomimetic amines [27], 1954-75
    17 53
    Pressor drugs - Angiotensin [26], 1942, 1957-76
    17 54
    Pressor drugs - Derived from biological materials [24], 1960
    17 55
    Cardiac drugs - Digitalis [22], 1948-60
    17 56
    Cardiac drugs - Quinidine, Pronestyl [21], 1951-60
    17 57
    Serotonin [14], 1952-59
    17 58
    Histamine [13], 1969
    17 59
    Depressor polypeptides (Bradykinin, etc.) [12], 1962-63
    17 60
    SI Units [11], 1986
     
    Studies Other than Hemodynamics [U-2], 1952-73 [subseries]:
    17 61
    Electrocardiograms [29], 1959
    17 62
    X-Ray [28], 1961
    17 63
    Extracellular fluid volume [26], 1952-63
    17 64
    Total body water [25], 1961
    17 65
    Total exchangeable sodium or potassium [23], 1955-61
    17 66
    Total blood volume [22], 1955-68
    17 67
    Muscle contraction, metabolism, cardiac contraction [21], 1962-63
    17 68
    Heart sounds and murmurs [20], 1955
    17 69
    Myogenic response [19], 1959-64
    17 70
    Electrokymography [18], 1962
    17 71
    Systolic time intervals [17], 1973
     
    Neural Control of Circulation [U-3], 1959-82 [subseries]:
    17 72
    Catecholamine metabolism [15], 1963-82
    17 73
    Pineal, including carbolines [14], 1962
    17 74
    Reflexes with afferents from heart and lung [13], 1959-75
    17 75
    Sympathetic vasodilator nerves [10], 1961
    17 76
    Sympathetic vasoconstrictor nerves [9], 1959-60
    17 77
    General or integrated [8], 1960-63
    17 78
    Baroreceptors [5], 1961-63, 1978
    17 79
    Hypothalamus [1], 1959-61
     
    Hemodynamic Techniques [U-4], 1949-87 [subseries]:
    17 80
    Blood Flow - Sonic [29], 1962
    17 81
    Blood Flow - Thermistor [28], 1949-71
    17 82
    Blood Flow - Electromagnetic [27], 1952-66
    17 83
    Blood Flow - Radiopotassium technique and similar [26], 1961-68
    17 84
    Blood Flow - Other special [25], 1950-61
    17 85
    Cardiac diameter mercury strain gauge [24], 1953
    17 86
    Cardiac "force" strain gauge [22], 1950-57
    17 87
    Blood viscosity [20], 1960-61
    17 88
    Electrical conductivity [19], 1959-61
    17 89
    Aortic or other large artery diameter - Methods other than x-ray [18], 1961
    17 90
    Limb Plethysmography - Strain gauge [17], 1964, 1980-84
    17 91
    Cardiac output by aortic pulse contour or differential pressure [16], 1949-65
    17 92
    Cardiac output by dye method [15], 1957-65, 1987
    17 93
    Blood pressure - Methods for measurement in man [14], 1959-86
    17 94
    Blood pressure - Methods for measurement in animals [13], 1957-66
    17 95
    Heart pumps [12], 1960-62
    17 96
    Renograms [11], 1963-71
    17 97
    Pulse wave velocity and contour [10], 1964
    17 98
    Microjuncture techniques [9], 1966
    17 99
    General animal technique (such as anesthesia, etc.) [8], 1963
    17 100
    Special animal techniques - Miscellaneous [7], 1963
    17 101
    Chronic implantation and catheterization technique [6], 1963
    17 102
    Echocardiography [5], 1971-74
     
    Environmental Factors [U-5], 1955-75 [subseries]:
    17 103
    Cold [28], 1955-62
    17 104
    Exercise [24], 1975
    17 105
    Hemodynamics - Postural hypotension [22], 1959-62
    17 106
    Dissecting aneurysm [11], 1966
     
    Effects of Changes Imposed on the Organism [U-6], 1940-81 [subseries]:
    17 107
    Exercise [29], 1954-59
    17 108
    Posture and postural hypertension [22], 1940-81
    17 109
    Smoking [21], 1959
    17 110
    Fever [20], 1959
    17 111
    Diving [19], 1962
    17 112
    Experimental ventricular pre-excitation [18], 1964
     
    Diseases States [U-7], 1945-83 [subseries]:
    17 113-114
    Cardiac failure [29], 1951-83
    17 115
    Myocardial infarction [28], 1954-76
    17 116
    Valvular heart disease [27], 1955-59
    17 117
    Congenital heart disease [26], 1955-64
    17 118
    Other heart disease [25], 1955
    17 119
    Pulmonary embolism and infarction [24], 1965
    17 120
    Peripheral vascular diseases - Arterial [22], 1955-62
    17 121
    Peripheral vascular diseases - Venous [21], 1955
    18 1
    Shock [19], 1945-64
    18 2
    Nephritis, glomerulo and pyelo [17], 1959
    18 3
    Other renal disorders [16], [1962]
    18 4
    Cerebrovascular disorders [14], [1963]
    18 5
    Arteriovenous fistula [12], 1960-62
    18 6
    Cardiac resuscitation [11], 1962-64
    18
    Computers and General [U-8], 1953-83 [subseries]:
    18 7
    Use as methodology aid [25], 1962
    18 8
    Diagnostic aid - general [24], 1962
    18 9
    Diagnostic aid - ECG [23], 1959-61, 1983
    18 10
    Hydrodynamics, hydraulics [14], 1953-58
    18
    Transmembrane Exchange [U-9], 1955-85 [subseries]:
    18 11
    Transcapillary exchange - Large molecules [29], 1960-63, 1984-85
    18 12
    Transcapillary exchange - Na[+ ]and K[+] [27], 1957-61
    18 13
    Transcapillary exchange - Water [26], 1962
    18 14
    Cellular membrane exchange - Na[+] and K[+] [24], 1955-62
    18 15
    Cellular membrane exchange - Water [23], 1959
    18 16
    Cellular membrane exchange - Other molecules [22], 1962
    18
    Cooperative Studies and Medical Statistics [U-10], 1960-85 [subseries]:
    18 17
    Methodology of cooperative studies [29], 1961-85
    18 18-19
    Double blind control studies in hypertension [28], 1960-77
    18 20
    Medical statistics - General [27], 1961-82
    18 21
    Medical research [26], 1964-76
    18 22
    Use of animals in research [25], [after 1952]
    18 23
    Medical ethics [24], 1966
    18
    [Subjects Not Filed by Freis], 1931-2000 [subseries]:
    18 24
    [Antihypertensive agents], 1947-56, 1977-92
    18 25
    [Antihypertensive therapy and side effects], 1950, 1973-95
    18 26
    Apex cardiogram etc., 1959-73
    18 27
    Arterial distensibility in normotensive and hypertensive patients, 1962-76, 1984
    18 28
    Arterial elasticity, 1959-65, 1978-87
    18 29-30
    Arterial pulse contours - literature, 1931, 1956-68
    21 2
    Arterial pulse contours - literature, 1965
    18 31
    Arterial wall characteristics [photographs], 1954-71
    18 32
    Arteriosonde for assessing "basal" BP, 1956, 1976-77
    18 33
    [Blood flow], 1949, 1976
    18 34
    Cards, 1968-70
    21 3-4
    Chronic Bright's Disease, 1974
    18 35
    Circadian rhythm study, 1988-89
    18 36
    [Congestive heart failure], 1953-91
    18 37
    Conjunctival blood vessels, 1983-86
    18 38-39
    Diuretic hypokalemia, 1963-94
    18 40
    Ejection period [photograph], 1964-77
    18 41
    Fixed dose combinations Rx, 1998
    18 42
    Heart sounds, 1958-72
    18 43
    [Hexamethonium], 1950-51
    18 44
    [High blood pressure], 1959-87
    18 45
    Isovolumic contraction time, 1959-76
    18 46
    [Kidneys], 1955-58
    18 47
    KCG [Kinetocardiogram] [photograph], 1959-76
    18 48-49
    [Leukocytes], 1959-84
    18 50
    New projects, 1950, 1979-89
    18 51
    PRA response to HCTZ and BP responsiveness correlation, 1983-90
    18 52
    [Propranolol], 1969-73
    18 53-54
    Pulse wave studies, 1955-89
    18 55-56
    Pulse wave velocity, 1945, 1960-71, 1989-2000
    18 57
    Rabbit Athero, 1955-64
    18 58
    Salt volume and prevention of hypertension, 1953-54, 1976-93
    19 1
    Sodium in WBC in hypertension and after antihypertensive drugs, 1959-76
    19 2
    Step down, 1975-89
    19 3-5
    Thiazides - Hypokalemia, 1962-93
    19 6
    Thiazides - Other side effects, 1991
    19 7
    Thoughts - Ideas, 1959-60, 1976-82
    19 8
    Transcapillary exchange in hypertension, 1963-80
     
    Series 5: Studies, ca. 1960-94 [series]:
    19 9
    The Effects of Change in Blood Pressure on Various Hemodynamic Events [photographs], ca. 1960
    19 10-12
    Arterial Pressure and the Effects of Depressor and Pressor Agents [photographs], 1961-62
    19 13
    Systolic Time Intervals, 1970
    19 14-15
    Effect of Length of Blood Pressure Cuff on Indirect Measurement of Blood Pressure [photographs], 1971
    19 16
    ECG Cooperative Study, 1972
    19 17
    Salt Handling by the Hypertensive Kidney, 1977
    19 18
    Lability of Blood Pressure in the Aged: Its Association with Baroreceptor Activity and Arterial Wall Stiffness, 1983-85
    19 19
    Veterans Administration Cooperative Study: Double-Blind Randomized Study to Evaluate the effects of Long-Term Antihypertensive Therapy on Plasma Lipids in Patients with Elevated Cholesterol Levels, 1989
    19 20
    Trandolapril and Trandolapril/Verapamil - Investigator's brochure, 1990
    19 21-24
    Veterans Administrations Cooperative Study #290: Monotherapy of Hypertension [Final draft volumes 1-3], 1991
    19 25
    Veterans Administrations Cooperative Study #290: Monotherapy of Hypertension [typescript], 1992
    19 26
    Accupril (Quinapril Hydrochloride, CI-906) - Investigator's brochure, 1991
    19 27
    Accupril - Formulary Data, 1991
    19 28
    ALLHAT Cooperative Study, 1993
    19 29
    Biobehavioral Triggers of Myocardial Ischemia, 1994
     
    Series 6: Photographs and Slides, 1972-85 [series]:
    20
    Personal Photographs, 1972-85 [subseries]:
    20 1
    Portraits of Dr. Freis [negatives only]
    20 2
    Portraits of Dr. Freis
    20 3
    Freis at unknown golf tournament, [ca. 1965]
    20 4
    Portraits of Dr. Freis [negatives only], 1972
    20 5
    Portrait of Dr. Freis [with negative], 1973
    20 6-9
    Photograph album - Trip to Moscow and Israel, 1977-85
    20 10
    Richard Freis and family, 1983
    20
    Professional, ca.1950-81 [subseries]:
    20 11
    [Veterans Administration staff], ca. 1950-62
    20 12
    Freis receiving awards, [1980]-82
    20 13
    Freis at 4th Scientific Meeting, International Society of Hypertension, 1981
     
    Illustrative Material for Publications and Lectures, 1969-89 [subseries]:
    20 14-15
    Photographs used in journal articles, 1956-78
    20 16
    Slides on hypertension, antihypertensive therapy, etc.
    20 17-18
    Scrapbook of slides for lectures and publications, 1969-89
    21 5
    Slide Atlas of Hypertension, 1980